Motif confirmation by HMMer


hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /home/niguts/usr02/tshini/ykclst/db/Pfam_fs
Sequence file:            hmm4/seq/T01H8.1b
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Query:  T01H8.1b  CE13014   Protein kinase C terminal domain status:Partially_confirmed TR:Q21734

Scores for sequence family classification (score includes all domains):
Model     Description                                   Score    E-value  N
--------  -----------                                   -----    ------- ---
pkinase   Protein kinase domain                         588.2   5.1e-173   2
pkinase_C Protein kinase C terminal domain               63.1    3.5e-18   1
PNPase    Polyribonucleotide nucleotidyltransferase,      2.5        4.4   1

Parsed for domains:
Model     Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------  ------- ----- -----    ----- -----      -----  -------
PNPase      1/1       3    17 ..     1    15 [.     2.5      4.4
pkinase     1/2      47   306 ..     1   294 []   290.5  2.1e-83
pkinase_C   1/1     307   371 ..     1    70 []    63.1  3.5e-18
pkinase     2/2     397   655 ..     1   294 []   298.1  1.1e-85

Alignments of top-scoring domains:
PNPase: domain 1 of 1, from 3 to 17: score 2.5, E = 4.4
                   *->Leekvaalaeerlse<-*
                      ++++v+++ae ++++
    T01H8.1b     3    ILAEVEEFAENEIEQ    17

pkinase: domain 1 of 2, from 47 to 306: score 290.5, E = 2.1e-83
                   *->yelleklGeGsfGkVykakhkd..ktgkiVAvKilkkekesikek..
                      +ell++lG+GsfGkV++++ + ++++g  +A+K+lk  k ++k +++
    T01H8.1b    47    FELLKVLGQGSFGKVFLVRKVRgrDSGHVYAMKVLK--KATLKVRdr 91

                   .rflrEiqilkrLsHpNIvrligvfedtddhlylvmEymegGdLfdylrr
                   +r+  E  il+++sHp+Iv+l+++f+ t+++lyl++++++gGdLf++l++
    T01H8.1b    92 qRTKLERNILAHISHPFIVKLHYAFQ-TEGKLYLILDFLRGGDLFTRLSK 140

                   nggplsekeakkialQilrGleYLHsngivHRDLKpeNILldendgtvKi
                   +   ++e+++k++  ++  +le+LHs giv+RDLKpeNILld + g++K+
    T01H8.1b   141 EV-MFTEDDVKFYLAELTLALEHLHSLGIVYRDLKPENILLDAD-GHIKV 188

                   aDFGLArlle.sssklttfvGTpwYmmAPEvilegrgysskvDvWSlGvi
                   +DFGL+++  +s  k+++f+GT +Ym APEv +++rg+s ++D WSlGv+
    T01H8.1b   189 TDFGLSKEAIdSEKKTYSFCGTVEYM-APEV-INRRGHSMAADFWSLGVL 236

                   LyElltggplfpgadlpaftggdevdqliifvlklPfsdelpktridple
                   ++E+ltg                          +lPf+++    r+d++
    T01H8.1b   237 MFEMLTG--------------------------HLPFQGR---DRNDTMT 257

                   elfriikrpglrlplpsncSeelkdLlkkcLnkDPskRpG..satakeil
                   ++++ ++        p+ +  e+++Ll+ +++++ ++R+G +    +ei+
    T01H8.1b   258 QILKAKLS------MPHFLTQEAQSLLRALFKRNSQNRLGagPDGVEEIK 301

                   nhpwf<-*
                    h +f
    T01H8.1b   302 RHAFF    306

pkinase_C: domain 1 of 1, from 307 to 371: score 63.1, E = 3.5e-18
                   *->reIdWdkLEnkeiePPFKPkiksprDtsNFDkeFTrekPvLTPvDsv
                      ++Id+ kL+nkei+PPFKP ++    ts+FD eFT+ +P ++P+  +
    T01H8.1b   307    AKIDFVKLLNKEIDPPFKPALSTVDSTSYFDPEFTKRTPKDSPALPA 353

                   lirsiDQeeFrGFSYvnsPersf<-*
                     +    e FrGFS+v+
    T01H8.1b   354 SANGH--EIFRGFSFVS-NA--V    371

pkinase: domain 2 of 2, from 397 to 655: score 298.1, E = 1.1e-85
                   *->yelleklGeGsfGkVykakhkdktgkiVAvKilkkekesikekrflr
                      ye+lek+G G+ ++V k++ k  t +++AvKi+k  k  ++   ++
    T01H8.1b   397    YEILEKIGNGAHSVVHKCQMK-ATRRKYAVKIVK--KAVFD---ATE 437

                   EiqilkrLs.HpNIvrligvfedtddhlylvmEymegGdLfdylrrnggp
                   E+ il r s+H ++v+l++v+e +++ +y++ E++egG+L+d l++++
    T01H8.1b   438 EVDILLRHShHQFVVKLFDVYE-DETAIYMIEELCEGGELLDKLVNKKSL 486

                   lsekeakkialQilrGleYLHsngivHRDLKpeNILlden...dgtvKia
                    seke+  i+  +l++++YLHs+ + HRDL ++NIL+  +++++  ++i
    T01H8.1b   487 GSEKEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKdgdPSSLRIV 536

                   DFGLArlle.sssklttfvGTpwYmmAPEvilegrgysskvDvWSlGviL
                   DFG+A++ +  +++l+t + T  ++ APEv l+ +gy++ +DvWSlGv+L
    T01H8.1b   537 DFGFAKQSRaENGMLMTPCYTAQFV-APEV-LRKQGYDRSCDVWSLGVLL 584

                   yElltggplfpgadlpaftggdevdqliifvlklPfsdelpktridplee
                   + +ltg                           +Pf   + +t++++l++
    T01H8.1b   585 HTMLTG--------------------------CTPFAMGPNDTPDQILQR 608

                   lfriikrpglrlplpsncSeelkdLlkkcLnkDPskRpGsatakeilnhp
                   + +++     + p+++++S+e+kdL++k+L++DP++R    tak++l+h+
    T01H8.1b   609 VGDGKIS--MTHPVWDTISDEAKDLVRKMLDVDPNRRV---TAKQALQHK 653

                   wf<-*
                   w+
    T01H8.1b   654 WI    655



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