Motif confirmation by HMMer


hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
HMM file:                 /home/niguts/usr02/tshini/ykclst/db/Pfam_fs
Sequence file:            hmm4/seq/R02C2.1
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query:  R02C2.1  CE21086   protein kinase status:Partially_confirmed TR:O44547 protein_id:AAD32717.1

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N
-------- -----------                                    -----    ------- ---
pkinase  Protein kinase domain                          483.4   1.8e-141   2

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
pkinase    1/2      18   280 ..     1   294 []   231.9    9e-66
pkinase    2/2     343   612 ..     1   294 []   252.6  5.5e-72

Alignments of top-scoring domains:
pkinase: domain 1 of 2, from 18 to 280: score 231.9, E = 9e-66
                   *->yelleklGeGsfGkVykakhkdkt.gkiVAvKilkk.ekesikekrf
                      ye++e lGeGsf++V ++  + +t++k +A+K+++  +k +   + +
     R02C2.1    18    YEFIENLGEGSFAEVVLVAKV-GTpNKMFAMKEISIvGKDECFMESI 63

                   lrEiqilkrLs...HpNIvrligvfedtddhlylvmEymegGdLfdylrr
                    rE +i krLs+++H N + l+++ +  ++++ l++ y++gGdLf+ + +
     R02C2.1    64 KRECSIQKRLSksrHLNMIHLFEIRT-NPENYQLILSYADGGDLFEKINQ 112

                   nggplsekeakkialQilrGleYLHsngivHRDLKpeNILldendgtvKi
                   +g  l+ +ea ++++Q+  Gl ++H++g+ HRD+KpeN+Ll++  g +Ki
     R02C2.1   113 HG-GLGSDEAHRYFKQLIDGLRFIHEEGVTHRDIKPENLLLTKS-GILKI 160

                   aDFGLArlle...sssklttfvGTpwYmmAPEvileg.rgysskvDvWSl
                   aDFG+A+  + ++  ++l+ ++G+p+Y+ APEv l g ++ +++vD+WS+
     R02C2.1   161 ADFGFATMHRfngAEQMLNAYCGSPPYI-APEV-LTGiDYRGPAVDIWSA 208

                   GviLyElltggplfpgadlpaftggdevdqliifvlklPfsdelpktrid
                   Gv+L+ +  g                            P+++     + d
     R02C2.1   209 GVVLIAMIAG--------------------------AVPWEQ---ADHFD 229

                   pleelfriikrpglrlplpsncSeelkdLlkkcLnkDPskRpGsatakei
                   +++  ++  +r ++r   +s+ S  +++Ll+k+L + ++ R    t+  i
     R02C2.1   230 IFQSRYCSFRR-NGRKGAWSRMSQQVISLLRKIL-LQAELRA---TISMI 274

                   lnhpwf<-*
                    ++pwf
     R02C2.1   275 EEDPWF    280

pkinase: domain 2 of 2, from 343 to 612: score 252.6, E = 5.5e-72
                   *->yelleklGeGsfGkVykakhkdktgkiVAvKilkk.ekesikekrfl
                      y+++e+l +GsfG+V ++++  +   +VAvK++ +++k++++ + ++
     R02C2.1   343    YKVVEHLCKGSFGQVHLCELTRNPSVKVAVKEVAVsGKSRKNLTAVQ 389

                   rEiqilkrLs...HpNIvrligvfedtddhlylvmEymegGdLfdylrrn
                    E +i++rLs+ +H+N++++  + e t++ + lvmEy++gGdLfd l+++
     R02C2.1   390 KEYKIHRRLSkigHENVIQMMKMIE-TPKFYSLVMEYADGGDLFDELKEQ 438

                   ggplsekeakkialQilrGleYLHsngivHRDLKpeNILlden.....dg
                     ++s k+a ++++Q+ +Gl+++H++givHRD+K eN+Ll+  ++++++g
     R02C2.1   439 E-KFSRKDAHSYFKQLIKGLKFIHEQGIVHRDIKLENLLLVYSeseddPG 487

                   tvKiaDFGLArlle...sssklttfvGTpwYmmAPEvilegrgysskvDv
                   t+Ki+DFGLA+++++++   +l+  +G+ +Y  APEv+  +++ +++vD+
     R02C2.1   488 TLKITDFGLATKYRkdgEEIMLSEDCGSKPYA-APEVCTGNDYRGPPVDI 536

                   WSlGviLyElltggplfpgadlpaftggdevdqliifvlklPfsdelpkt
                   WS+Gv+L  +l g                          +  ++     +
     R02C2.1   537 WSAGVVLMTMLVG--------------------------EHSWK----VA 556

                   ridpleelfriikrpglrlplpsncSeelkdLlkkcLnkDPskRpGsata
                   ++++ +++ + i+ ++++  l+  +S +   Ll+k+L+ +P+kR    t+
     R02C2.1   557 NKEKDAAYSNWINAKDEKANLWNVISGPTTALLRKLLHANPEKRA---TM 603

                   keilnhpwf<-*
                     i ++pwf
     R02C2.1   604 AKIEADPWF    612



[DB home][top]