Motif confirmation by HMMer
hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file: /home/niguts/usr02/tshini/ykclst/db/Pfam_fs
Sequence file: hmm4/seq/M106.4
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Query: M106.4 CE18084 GMP synthase status:Partially_confirmed SW:Q09580 protein_id:CAA87052.1
Scores for sequence family classification (score includes all domains):
Model Description Score E-value N
-------- ----------- ----- ------- ---
GMP_synt_C GMP synthase C terminal domain 390.3 1.9e-113 1
GATase Glutamine amidotransferase class-I 161.1 1.8e-44 1
tRNA_Me_trans tRNA methyl transferase 21.2 7.1e-06 1
UPF0021 PP-loop family UPF0021 17.0 0.0011 1
PAPS_reduct Phosphoadenosine phosphosulfate reducta 8.2 0.78 1
Complex1_51K Respiratory-chain NADH dehydrogenase 51 4.2 6.1 1
ThiI Thiamine biosynthesis protein (ThiI) 2.9 9.6 1
Parsed for domains:
Model Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
Complex1_51K 1/1 136 159 .. 237 268 .] 4.2 6.1
GATase 1/1 109 293 .. 1 269 [] 161.1 1.8e-44
ThiI 1/1 321 334 .. 5 18 .. 2.9 9.6
tRNA_Me_trans 1/1 320 342 .. 1 23 [. 21.2 7.1e-06
PAPS_reduct 1/1 323 354 .. 1 33 [. 8.2 0.78
UPF0021 1/1 321 354 .. 1 40 [. 17.0 0.0011
GMP_synt_C 1/1 513 791 .. 1 224 [] 390.3 1.9e-113
Alignments of top-scoring domains:
Complex1_51K: domain 1 of 1, from 136 to 159: score 4.2, E = 6.1
*->pmGttLREliedygGGvrgGwdelkAVqpGGP<-*
p++tt R lie GG+ + + ++ GGP
M106.4 136 PLNTTARTLIEL--GGF----KGI--IISGGP 159
GATase: domain 1 of 1, from 109 to 293: score 161.1, E = 1.8e-44
*->lliDngdSftynlvralrelGaelegvevtvvpndtsssdaeeietl
+++D+g+++ + + r++rel v+++ +p +t +a ++ +
M106.4 109 AILDFGAQYGKVIDRRVRELL-----VQSEMFPLNT---TARTL--I 145
eeieelllnpdgiiiSpGPGdPgaAmdeLnaggsieaikelrenplkiPi
e l +++giiiS+GP ++ + ++ ++ e++ +++P+
M106.4 146 E-----LGGFKGIIISGGPNSVFE-------PEAPSIDPEIFT--CGLPV 181
LGICLGhQllalafGgnvglgAnStEFdpeTkwpglkvvpgkvrleasDe
LGIC+G+Ql+ + Gg +v
M106.4 182 LGICYGFQLMNKLNGG--------------------TVT----------- 200
nimekakkephhGknspvghdgcglpgtvslaplfyglpnpfivrryHsy
+++ ++++ + v+ +lf gl + ++v H++
M106.4 201 ----REHIREDGACEIQVDT----------SVHLFNGLHKTETVLLTHGD 236
avdpeyiestlPegkglevtaasdddggesegeimairhkenHPfifGVQ
v ++ t+ ++ ++v a+s +a +++en ++++GVQ
M106.4 237 SVSEA----TVAPD--FKVMAKS-G-------HHVAGICNEN-RKLYGVQ 271
FHPEssltpgGpelLfnffikl<-*
FHPE+ lt++G+++++nf+ k+
M106.4 272 FHPEVDLTTNGTKMFENFLFKV 293
ThiI: domain 1 of 1, from 321 to 334: score 2.9, E = 9.6
*->kvlaLLSGGIDSPV<-*
kvl++ SGG DS+V
M106.4 321 KVLVMVSGGVDSAV 334
tRNA_Me_trans: domain 1 of 1, from 320 to 342: score 21.2, E = 7.1e-06
*->mkVvVaMSGGVDSSVaAyLLkeq<-*
+kV+V SGGVDS+V A+LL+++
M106.4 320 KKVLVMVSGGVDSAVCAALLRRA 342
PAPS_reduct: domain 1 of 1, from 323 to 354: score 8.2, E = 0.78
*->VllssfGkdssVllhLaskafppglpfpvifvD<-*
+ s+G ds+V L+++a p +++ i++D
M106.4 323 LVMVSGGVDSAVCAALLRRALGP-NRVTAIHID 354
UPF0021: domain 1 of 1, from 321 to 354: score 17.0, E = 0.0011
*->kiLvAvSGGlDSmvLLylLkklkpklapgiineltaaHvd<-*
k+Lv vSGG+DS v + lL++ l g n++ta+H+d
M106.4 321 KVLVMVSGGVDSAVCAALLRRA---L--GP-NRVTAIHID 354
GMP_synt_C: domain 1 of 1, from 513 to 791: score 390.3, E = 1.9e-113
*->GPGLAIRIiCa....................................
GPGLAIRI+Ca++++++ +++ +++ +++ + +++ ++ ++
M106.4 513 GPGLAIRILCAsdkrpelmfngpmyngdvqgriidvteqflnsainp 559
.........GEvteekleilreadaIvRvkvllseeElkkaglyqdiwQa
+++ ++ ++E++ R++vlls +E++++ ++q+++Q+
M106.4 560 sqgiyehlqFEQA--------------RNNVLLSLSERDRQLAEQQTFQI 595
favLLpiksVGVqGDgRtYsyvvglss..deipWkllfalArvIPklcHn
+a++Lpik+VGVqGD+R+Ysy+v+ls+++++ipWkllfa+A+vIPkl+H+
M106.4 596 SAHILPIKTVGVQGDARSYSYAVALSTeqRPIPWKLLFAYASVIPKLFHG 645
vNRVVyiFg.............epvkhitptlltadvikqlrladsvaae
vNRVVy+Fg++ + + ++ +++++v+hi+++l++ad+i++++l+++vaa+
M106.4 646 VNRVVYAFGskiefsiedltrtYLVPHIVTKLQMADHIANNILFGRVAAS 695
dlrklnlvgklsQvpvvvlpldf.........syrrSialRavessDfMT
d+++l++vg+++Q+++vvl++++ +++++ +syr+Si+lR++ +sDfMT
M106.4 696 DGTQLPNVGHKIQQMPVVLLPVDfdrdrdmigSYRHSIVLRPFVTSDFMT 745
AdwaiPGkrlpydfLkriskRItnEVkgvsRVvYDiTsKPPaTIEW<-*
+++aiPG++lp+++L +++k+I+++V g+sRV++D+T+KPP+T+EW
M106.4 746 GQAAIPGVHLPEETLIEMDKAIRTNVLGISRVLLDMTCKPPGTTEW 791