Motif confirmation by HMMer
hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file: /home/niguts/usr02/tshini/ykclst/db/Pfam_fs
Sequence file: hmm3/seq/K11E4.4
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Query: K11E4.4 CE18886 Src homology domain 3 status:Partially_confirmed TR:Q21430 protein_id:CAA94159.1
Scores for sequence family classification (score includes all domains):
Model Description Score E-value N
-------- ----------- ----- ------- ---
SH3 SH3 domain 60.7 4.9e-15 1
RhoGEF RhoGEF domain 7.8 0.37 1
PH PH domain 6.5 2 1
Parsed for domains:
Model Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
SH3 1/1 188 242 .. 1 58 [] 60.7 4.9e-15
RhoGEF 1/1 275 432 .. 1 192 [. 7.8 0.37
PH 1/1 493 562 .. 16 67 .. 6.5 2
Alignments of top-scoring domains:
SH3: domain 1 of 1, from 188 to 242: score 60.7, E = 4.9e-15
*->pkvvALYDYeaeesdELsFkkGDvitvleksddgWWkgrlkgtgGke
++A++ +e+++ dELsF k D+it+ +++++gWW+g G +
K11E4.4 188 LSARAKFQFEGSNNDELSFDKDDIITITQQQEGGWWEGTHE---GVT 231
GlvPsNYVepv<-*
G++P+ YV+++
K11E4.4 232 GWFPCAYVTLI 242
RhoGEF: domain 1 of 1, from 275 to 432: score 7.8, E = 0.37
*->vlkElleTEkkYvrdLeildnvymkpLreaaisskpvltpddietiF
vlk+ +e+Ek+Y ++L +++ + p ++ +lt+ + t+
K11E4.4 275 VLKSYIESEKEYMQSLLKTLQSLLIPIGASK-----ILTAPEYCTLV 316
sNiediyefhreFLkssLearisssqfedlDekkiepsaqrlGdlFlklk
+N e iy++ r+++ Le + ++ ++ r+G F+
K11E4.4 317 GNFEVIYTLKRDLFE-QLEREQNEE-----------LPKMRVGGMFMNAA 354
epflqvYgeYcsnkpyAqelleklrqaasnpqFaefldeveassntgAkd
++ +Y +n+p+A+e+l+k ++++ +++++++e +
K11E4.4 355 LELRTALMSYADNHPDAVEVLKK---KQKELEKVVKSQDREYK------- 394
davkltLqsLLlkPvqRilrYpLLLkeLLkhtpegedqpdredLk<-*
+l L L++P+ ++ rY LL+eL p+ +pdr dL+
K11E4.4 395 ---ELVLG--LSEPLRHVERYYNLLQELERIVPA--NHPDRGDLQ 432
PH: domain 1 of 1, from 493 to 562: score 6.5, E = 2
*->kRyfvLfndvLlyykdsk...kkpkgsipLsgcqvek.pd.......
+R++ Lf++++++++ k+ +++ k ++ +sg +v+k+++++ + ++
K11E4.4 493 DRFVALFTKYIMFFEVTKdmtYDIKEKFTVSGFIVRKkEAteisfdr 539
....kncFeirt.dr..tlllqa<-*
++++++++ ++++++ + +l a
K11E4.4 540 pntgEFTLTMVStGGevERFLVA 562