Motif confirmation by HMMer
hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file: /home/niguts/usr02/tshini/ykclst/db/Pfam_fs
Sequence file: hmm3/seq/F58A3.2a
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Query: F58A3.2a CE28238 locus:egl-15 IG (immunoglobulin) superfamily (3 domains), protein tyrosine kinase (fibroblast growth factor subfamily)
Scores for sequence family classification (score includes all domains):
Model Description Score E-value N
-------- ----------- ----- ------- ---
pkinase Protein kinase domain 270.2 2.7e-77 1
ig Immunoglobulin domain 67.1 6.3e-17 3
Utp14 Utp14 protein 4.2 1.6 1
Parsed for domains:
Model Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
ig 1/3 48 111 .. 1 50 [] 17.5 0.0034
ig 2/3 307 369 .. 1 50 [] 28.2 3.8e-06
ig 3/3 407 487 .. 1 50 [] 21.4 0.00029
Utp14 1/1 579 627 .. 1 55 [. 4.2 1.6
pkinase 1/1 640 931 .. 1 294 [] 270.2 2.7e-77
Alignments of top-scoring domains:
ig: domain 1 of 3, from 48 to 111: score 17.5, E = 0.0034
*->GesvtLtCsvsgfgpp.p.vtWlrngk.le............tssls
G+ ++ C + ++ v W+rn+k l +++ ++++ +++++
F58A3.2a 48 GDEIKFDCQTA-ASKIsAfVEWYRNDKlLKndqidkdkirkdNNRMM 93
lti.svtpeDsgGtYtCvv<-*
l++++ +D G +C+v
F58A3.2a 94 LHLkNIDVSDQ-GLWSCRV 111
ig: domain 2 of 3, from 307 to 369: score 28.2, E = 3.8e-06
*->GesvtLtCsvsgfgpp.p.vtWlrngk.le............tssls
G +++L+C+++ g p+p++ W++ngk l +++ ++++ + + + s
F58A3.2a 307 GRTLKLNCRAK--GYPePqIIWYKNGKmLKkssarsggyefkFNRWS 351
lti.svtpeDsgGtYtCvv<-*
l+++++ Ds G++ C++
F58A3.2a 352 LEVeDAVVADS-GEFHCEA 369
ig: domain 3 of 3, from 407 to 487: score 21.4, E = 0.00029
*->GesvtLtCsvsgfgpp.p.vtWlrngk.le.................
++++t+ C v ++ p++ W r +k ++ + +++ ++ + +
F58A3.2a 407 NDTATFHCKVV--SDLlPhIIWVRINKiNGsysyynnsaeeymfnyt 451
.............tsslslti.svtpeDsgGtYtCvv<-*
+ ++ ++ + ++ ++lti +v+ +D G+Y C
F58A3.2a 452 emdtfdkahvhhvGDESTLTIfNVSLDDQ-GIYACLS 487
Utp14: domain 1 of 1, from 579 to 627: score 4.2, E = 1.6
*->eSdDeedESdseeeEedsdDdaHqklLqaitsldtvkkikeskrskr
+++D+e+ +++++++ q + it+ ++k+++ +s+
F58A3.2a 579 MNEDNEN------SDDEPSPYQIQIIETPITKKEAARKQRKRMNSEN 619
kktesyke<-*
+ + +y +
F58A3.2a 620 TVLSEYEV 627
pkinase: domain 1 of 1, from 640 to 931: score 270.2, E = 2.7e-77
*->yelleklGeGsfGkVykakhkd..ktgkiVAvKilkkekesikekrf
+ l+ lGeG+fG+V+ka++k +++++ VAvK+lk +++++ +++
F58A3.2a 640 LSLVHMLGEGAFGEVWKATYKEteNNEIAVAVKKLKMSAHEKELIDL 686
lrEiqilkrLs.HpNIvrligvfedtddhlylvmEymegGdLfdylrrng
+E++ k + +H+N++rlig ++ ++ly+v E++ +G L+d+lr+++
F58A3.2a 687 VSEMETFKVIGeHENVLRLIGCCT-GAGPLYVVVELCKHGNLRDFLRAHR 735
...............................gplsekeakkialQilrGl
+++++ ++++++ ++ ++++ +++++ + +l+ ++++ +a+Q+++G+
F58A3.2a 736 pkeekakkssqeltdyleprkasdkddieliPNLTQRHLVQFAWQVAQGM 785
eYLHsngivHRDLKpeNILldendgtvKiaDFGLArlle..sssklttfv
++L s++i+HRDL+++N+L+ + +++Ki+DFGL+r+++ ++++++ +++
F58A3.2a 786 NFLASKKIIHRDLAARNVLVGDG-HVLKISDFGLSRDVHcnDYYRKRGNG 834
GTpwYmmAPEvilegrgysskvDvWSlGviLyElltggplfpgadlpaft
p +mA E l ++ y+ ++DvWS+Gv+L+E++t g
F58A3.2a 835 RLPIKWMALEA-LDSNVYTVESDVWSYGVLLWEIMTLG------------ 871
ggdevdqliifvlklPfsdelpktridpleelfriikrpglrlplpsncS
++P++ + + el++ +k+ g+r+++p++c+
F58A3.2a 872 -------------GTPYP-------TIAMPELYANLKE-GYRMEPPHLCP 900
eelkdLlkkcLnkDPskRpGsatakeilnhp.wf<-*
e+++L+++c++ ++Rp ++k i+ ++w+
F58A3.2a 901 QEVYHLMCSCWREKLEERP---SFKTIVDYLdWM 931