Motif confirmation by HMMer


hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /home/niguts/usr02/tshini/ykclst/db/Pfam_fs
Sequence file:            hmm2/seq/F08F8.2
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Query:  F08F8.2  CE30649   Hydroxymethylglutaryl-coA reductase status:Confirmed TR:Q19207 protein_id:AAA68386.2

Scores for sequence family classification (score includes all domains):
Model           Description                             Score    E-value  N
--------        -----------                             -----    ------- ---
HMG-CoA_red     Hydroxymethylglutaryl-coenzyme A redu   897.0   1.7e-272   1
CUT             CUT domain                                4.9        2.8   1
Glyco_tran_28_C Glycosyltransferase family 28 C-termi     3.6        5.9   1

Parsed for domains:
Model           Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------        ------- ----- -----    ----- -----      -----  -------
CUT               1/1     236   255 ..    69    88 .]     4.9      2.8
HMG-CoA_red       1/1     112   500 ..     1   426 []   897.0 1.7e-272
Glyco_tran_28_C   1/1     473   523 ..   125   179 .]     3.6      5.9

Alignments of top-scoring domains:
CUT: domain 1 of 1, from 236 to 255: score 4.9, E = 2.8
                   *->MqnWLsdpnavrdlilqqek<-*
                      M++WL+ p+++ +++ + ++
     F08F8.2   236    MKRWLEHPENQDRARQEFQS    255

HMG-CoA_red: domain 1 of 1, from 112 to 500: score 897.0, E = 1.7e-272
                   *->kiplyeLEsrLgadperAveiRReaieklatgkklearLkklPyegy
                      + +++eLEsr++  +e+A+ iRR++i+k     k+e+    lPy gy
     F08F8.2   112    QAKSRELESRFP--AEQAIPIRRTFINK-----KFEN----LPYLGY 147

                   DyekvlgaCCENVIGYvpiPvGvAGPLllDGkyakGeyyvPMATTEGaLV
                   Dy++++++CCENVIGY p+PvGvAGPL+l+G++   e+yvPMATTEGaL+
     F08F8.2   148 DYTLATECCCENVIGYTPVPVGVAGPLTLNGTS---EIYVPMATTEGALI 194

                   AStNRGckaitasGGatsvvlkdgMTRAPvVrfpsvvrAaelklwlespE
                   AStNRG+++i+a+GG++++++++gMTRAPvV+fp++++A+++k wle+pE
     F08F8.2   195 ASTNRGMNVIRAAGGVETSIFNSGMTRAPVVKFPTARDAVSMKRWLEHPE 244

                   NfealkeaFdsLTSRFgrLqsIkiiviDtiaGrnlYlRFratTGDAMGMN
                   N+++++++F+s +SRF++L+sI+i    ti+G+ +YlRF+a+TGDAMGMN
     F08F8.2   245 NQDRARQEFQS-CSRFAKLKSIDI----TIDGNLAYLRFDAHTGDAMGMN 289

                   MVSKgvEkaLefleeitgegfpdMeiiSlSGNyCtDKKpAAiNwieGRGK
                   M+SK ++++++fl+e+    fp+M++++lSGN+C+DKK+AA Nw+eGRG+
     F08F8.2   290 MISKSCDSTMRFLMEN----FPEMTVLALSGNLCVDKKAAAKNWTEGRGR 335

                   sVVaEatIpgdvVrkvLKTtvealvelNiaKNLiGSAmAGSiGgnGFNAH
                   sVVaE++Ip++vV+k+L+Tt+e+l++l+++K +iGS++AG++G  G NAH
     F08F8.2   336 SVVAECLIPREVVTKTLRTTPEQLAYLTTTKLHIGSSRAGAVG--GSNAH 383

                   aANIVtAiFiATGQDpAQnVESSnCiTlmEvveePMaVGlvGGAdggDLy
                   aANIV+AiFiATGQD+AQ+V SS+C+T mEv++            +++Ly
     F08F8.2   384 AANIVAAIFIATGQDAAQVVSSSMCSTRMEVTA------------DKNLY 421

                   iSVTMPSlEVGTVGGGTrLapQsACLdlLGVkGanatsPGqNAhqLAriv
                   +S+T+P++EVGTVGGGT+LapQ+ACL+ LG+ G+n+++PGqNA++LA+++
     F08F8.2   422 VSCTLPCVEVGTVGGGTILAPQRACLESLGCAGPNKEQPGQNAERLAEVI 471

                   aaaVLAGELSLmsALaaghLVksHmklNR<-*
                   aa+VLAGELSLm+AL++++LV+sHmklNR
     F08F8.2   472 AATVLAGELSLMAALTTNELVSSHMKLNR    500

Glyco_tran_28_C: domain 1 of 1, from 473 to 523: score 3.6, E = 5.9
                   *->vkagaaevllqkeltllpekLaeallklllkplklyemakaagaakr
                      ++++a+e  l + lt  +++L++  +kl++++++ly+ ++   +a
     F08F8.2   473    ATVLAGELSLMAALT--TNELVSSHMKLNRSKQQLYADDSG--KATH 515

                   ikdaierl<-*
                   + + +e+
     F08F8.2   516 FEKEVEKA    523



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