Motif confirmation by HMMer
hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file: /home/niguts/usr02/tshini/ykclst/db/Pfam_fs
Sequence file: hmm1/seq/B0334.8
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Query: B0334.8 CE23506 locus:age-1 phosphatidylinositol 3-kinase status:Confirmed SW:Q94125 protein_id:CAA91377.2
Scores for sequence family classification (score includes all domains):
Model Description Score E-value N
-------- ----------- ----- ------- ---
PI3_PI4_kinase Phosphatidylinositol 3- and 4-kinase 189.8 4.2e-53 2
PI3K_p85B PI3-kinase family, p85-binding domain 170.3 3.2e-47 1
PI3K_C2 C2 domain 147.6 1.8e-41 1
PI3K_rbd PI3-kinase family, ras-binding domain 145.5 9.2e-40 1
PI3Ka Phosphoinositide 3-kinase family, acce 63.8 1.1e-17 1
Agglutinin Lectin (probable mannose binding) 4.9 6.8 1
DUF404 Domain of unknown function (DUF404) 3.3 6.4 1
IL7 Interleukin 7/9 family 3.0 8.7 1
Glyco_hydro_63 Mannosyl oligosaccharide glucosidase 1.8 5.2 1
Parsed for domains:
Model Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
PI3K_p85B 1/1 62 141 .. 1 80 [] 170.3 3.2e-47
PI3K_rbd 1/1 205 325 .. 1 116 [] 145.5 9.2e-40
IL7 1/1 341 369 .. 1 29 [. 3.0 8.7
PI3K_C2 1/1 389 550 .. 1 205 [] 147.6 1.8e-41
Glyco_hydro_63 1/1 559 567 .. 926 934 .] 1.8 5.2
DUF404 1/1 745 752 .. 301 308 .] 3.3 6.4
PI3Ka 1/1 625 762 .. 67 215 .] 63.8 1.1e-17
PI3_PI4_kinase 1/2 848 913 .. 1 97 [. 74.3 3.1e-19
PI3_PI4_kinase 2/2 969 1095 .. 185 335 .] 118.3 1.5e-31
Agglutinin 1/1 1123 1137 .. 112 126 .] 4.9 6.8
Alignments of top-scoring domains:
PI3K_p85B: domain 1 of 1, from 62 to 141: score 170.3, E = 3.2e-47
*->lveLrvsrEatlsvIKheLfkqakkmPlgtllkdaqsYvFvqvnqta
l+++r+s+E++ls++Kh+Lf+++++m++gt+++++q+YvF+q+n+++
B0334.8 62 LANVRTSLEIKLSDFKHQLFELIAPMKWGTYSVKPQDYVFRQLNNFG 108
eiEelfDETrRLsdlrlfGTfPiLkLverdgtn<-*
eiE++f+++++Ls+l+l+GTfP+L+L+++dg+n
B0334.8 109 EIEVIFNDDQPLSKLELHGTFPMLFLYQPDGIN 141
PI3K_rbd: domain 1 of 1, from 205 to 325: score 145.5, E = 9.2e-40
*->astlsPeplpnKlinnkllisvhlekr......vknkqqtkTltcnp
+++++P++l++K++++kl+++++++kr+ + ++v++k++++++++np
B0334.8 205 VGESCPKDLESKVKAAKLSYQMFWRKRkaeingVCEKMMKIQIEFNP 251
nsTpesliaqaltKfakklsvltqndvtdeedYvLKVcGrdEYLl.gdhp
n+Tp+sl++++l++ ++kl+v++++d++de+++ L+++Gr+++++++d++
B0334.8 252 NETPKSLLHTFLYE-MRKLDVYDTDDPADEGWF-LQLAGRTTFVTnPDVK 299
LgqfeyIrnclksgrephLvLvesss<-*
L++++++r++l+s+r+p++v++++s
B0334.8 300 LTSYDGVRSELESYRCPGFVVRRQSL 325
IL7: domain 1 of 1, from 341 to 369: score 3.0, E = 8.7
*->dllgkdgkayesvlmVsidglldlmgilD<-*
+ + + k ++ vl+Vsid + + ++ D
B0334.8 341 YVRAHERKLALDVLSVSIDSTPKQSKNSD 369
PI3K_C2: domain 1 of 1, from 389 to 550: score 147.6, E = 1.8e-41
*->lnrplrikivaasrinlnwlyddkysdlyvecslyDghggepLckpv
l+ +l+i+ v++s++ ++ +d ++++ +e+s+y g+ L+
B0334.8 389 LDANLMIRPVNISGFDFP---ADVDMYVRIEFSVY--VGTLTLA--S 428
qsTsykpfsSlldgffpsvkWn.ewltFpikisdLPrdArLvitlyevkg
+sT ++ + ++kWn+e++tF+++++d+P++A+L+i + ++k
B0334.8 429 KSTTKVNAQ--------FAKWNkEMYTFDLYMKDMPPSAVLSIRVLYGKV 470
ksksekStdsikeiqaaekkkveplGwvnlsLFdkekgiLrqGpqlLslt
k kse+ +++Gwvn+sL+d+ ++ LrqG++l++l
B0334.8 471 KLKSEE----------------FEVGWVNMSLTDW-RDELRQGQFLFHL- 502
WpskepdesvptsTPGKvplesrdelnrLekllkkyerGdvqpnpvvdwl
W+++++++++++ +e++++++++++ + ++++ +v++
B0334.8 503 WAPEPTANRSRI-----------GENGARIGTNAAVTIEISSYGGRVRMP 541
Dfltlreie<-*
++ +++++
B0334.8 542 SQGQYTYLV 550
Glyco_hydro_63: domain 1 of 1, from 559 to 567: score 1.8, E = 5.2
*->VlLIMsEny<-*
+l+IM+++y
B0334.8 559 TLNIMGDDY 567
DUF404: domain 1 of 1, from 745 to 752: score 3.3, E = 6.4
*->LveAyRqG<-*
L+eAy++G
B0334.8 745 LMEAYLRG 752
PI3Ka: domain 1 of 1, from 625 to 762: score 63.8, E = 1.1e-17
*->WsdlsevaealsLldkWvWqapidpvdALELLdpkFadnheeVReYA
W+d++ e + l kW p +++ AL LL+ +d + +R +A
B0334.8 625 WTDRENFSELYVMLEKW---KPPSVAAALTLLGKRCTD--RVIRKFA 666
VkcLesYasDdELlfYLLQLVQALKYEnldepfhdSpLsrFLlkRAlkNr
V++L+ +s+ + +++L L QALKYE p S + Ll RAl
B0334.8 667 VEKLNEQLSPVTFHLFILPLIQALKYE----PRAQSEVGMMLLTRALCDY 712
srlGHfFfWyLksEi..YKDdldhdeevkserFgvllEsylrectgtsle
r+GH +fW L++Ei + +D +++ee+ r+++l+E+ylr+ +++
B0334.8 713 -RIGHRLFWLLRAEIarLRDCDLKSEEY--RRISLLMEAYLRGN-EEHIK 758
dlnk<-*
+
B0334.8 759 IITR 762
PI3_PI4_kinase: domain 1 of 2, from 848 to 913: score 74.3, E = 3.1e-19
*->gyafifKgGdDlrsrqDervlQliaVFKPkDEEPyAplNPkgtkwsh
+a+ifK+GdDlr qD++vlQ +
B0334.8 848 FCAMIFKNGDDLR--QDMLVLQVL----------------------- 869
GerlmnkllkgegldrrRnlqltaYlviplgsrsGliewvpnattlaeip
++m++++k + d + l++Y+v+p+g+ G+ie+vpn+ t+ ei+
B0334.8 870 --EVMDNIWKAANIDCC----LNPYAVLPMGEMIGIIEVVPNCKTIFEIQ 913
<-*
B0334.8 - -
PI3_PI4_kinase: domain 2 of 2, from 969 to 1095: score 118.3, E = 1.5e-31
*->ewfarfeeLtearknfvrScAgmsvldYiLgngDRHldNiLvkkdkk
++f+ + + f +Sc g+sv++Yi+g+ DRH dN+++ ++
B0334.8 969 KYFE-------SVDRFLYSCVGYSVATYIMGIKDRHSDNLML---TE 1005
tGklfHIDFGlcfphskgkrgekpervPFrLTrWPQaklpfveamggyia
+Gk fHIDFG++++h k+k g+ ++r PF LT f +++ +++
B0334.8 1006 DGKYFHIDFGHILGHGKTKLGIQRDRQPFILTE------HFMTVIRSGKS 1049
sLgpsgdeglFrelceeayralRrnlnlltnlLkqkavarGllmledglp
g+s + ++F++lc+eay+++ n +l+++l+ lml +lp
B0334.8 1050 VDGNSHELQKFKTLCVEAYEVMWNNRDLFVSLF--------TLMLGMELP 1091
dwrs<-*
+++
B0334.8 1092 ELST 1095
Agglutinin: domain 1 of 1, from 1123 to 1137: score 4.9, E = 6.8
*->iygsrsltiWstgtn<-*
iy +++ +Wst tn
B0334.8 1123 IYEEAFNGSWSTKTN 1137
[output cut off at A = 10 top alignments]