Homology by BLASTX


BLASTX 2.2.4 [Aug-26-2002]
Query= F54D1_5
         (4092 letters)

Database: /home/niguts/usr02/tshini/ykclst/db/nr.seq
           1,967,186 sequences; 661,712,633 total letters


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7504163|pir||T22644 hypothetical protein F54D1.5 - Caenorhabd...  2686   0.0
gi|15718227|emb|CAB00861.2| C. elegans GTL-2 protein (correspond...  2686   0.0
gi|39593744|emb|CAE62037.1| Hypothetical protein CBG06053 [Caeno...  2503   0.0
gi|32565923|ref|NP_502118.2| Gon-Two Like, TRP subfamily (gtl-2)...  2200   0.0
gi|50511021|dbj|BAD32496.1| mKIAA1616 protein [Mus musculus]          759   0.0
gi|30141363|emb|CAD43605.1| long transient receptor potential ch...   758   0.0
gi|48104806|ref|XP_395849.1| similar to ENSANGP00000005757 [Apis...   730   0.0
gi|31199943|ref|XP_308919.1| ENSANGP00000005757 [Anopheles gambi...   730   0.0
gi|47214189|emb|CAG00817.1| unnamed protein product [Tetraodon n...   721   0.0
gi|19922314|ref|NP_611026.1| CG30078-PA [Drosophila melanogaster...   715   0.0
gi|29893552|ref|NP_060142.2| transient receptor potential cation...   702   0.0
gi|13959785|gb|AAK44211.1| LTRPC7 [Homo sapiens]                      702   0.0
gi|50753109|ref|XP_425074.1| PREDICTED: similar to transient rec...   695   0.0
gi|10946830|ref|NP_067425.1| transient receptor potential cation...   691   0.0
gi|14211383|gb|AAK57433.1| transient receptor potential phosphol...   691   0.0
gi|14009344|gb|AAK50377.1| LTRPC7 [Mus musculus]                      691   0.0
gi|45935360|ref|NP_996827.1| transient receptor potential cation...   687   0.0
gi|27597209|dbj|BAC55104.1| hypothetical protein [Homo sapiens]       687   0.0
gi|45935362|ref|NP_996828.1| transient receptor potential cation...   686   0.0
gi|47214200|emb|CAG00828.1| unnamed protein product [Tetraodon n...   685   0.0
gi|28274684|ref|NP_066003.1| transient receptor potential cation...   684   0.0
gi|45935358|ref|NP_079247.3| transient receptor potential cation...   683   0.0
gi|34861963|ref|XP_219747.2| similar to transient receptor poten...   681   0.0
gi|28626251|gb|AAO49155.1| calcium-permeable store-operated chan...   679   0.0
gi|24653815|ref|NP_725447.1| CG30078-PB [Drosophila melanogaster...   678   0.0
gi|37790764|gb|AAR03488.1| transient receptor potential cation c...   678   0.0
gi|18921093|ref|NP_060132.3| transient receptor potential cation...   677   0.0
gi|37790766|gb|AAR03489.1| transient receptor potential cation c...   677   0.0
gi|37790768|gb|AAR03490.1| truncated transient receptor potentia...   677   0.0
gi|45935366|ref|NP_996830.1| transient receptor potential cation...   677   0.0
gi|27597207|dbj|BAC55103.1| hypothetical protein [Homo sapiens]       677   0.0
gi|23510305|ref|NP_700466.1| transient receptor potential cation...   676   0.0
gi|45935364|ref|NP_996829.1| transient receptor potential cation...   674   0.0
gi|27597213|dbj|BAC55106.1| hypothetical protein [Homo sapiens]       660   0.0
gi|50752897|ref|XP_425066.1| PREDICTED: similar to transient rec...   641   0.0
gi|50761814|ref|XP_429161.1| PREDICTED: similar to transient rec...   597   e-169
gi|47225840|emb|CAF98320.1| unnamed protein product [Tetraodon n...   584   e-165
gi|24412718|emb|CAC81667.1| putative TRP homologous cation chann...   565   e-159
gi|32565925|ref|NP_502111.2| Gon-Two Like, TRP subfamily (gtl-1)...   565   e-159
gi|30145746|emb|CAA92726.2| Hypothetical protein C05C12.3 [Caeno...   565   e-159
gi|7495413|pir||T18951 hypothetical protein C05C12.3 - Caenorhab...   565   e-159
gi|39593737|emb|CAE62030.1| Hypothetical protein CBG06044 [Caeno...   555   e-156
gi|26336493|dbj|BAC31929.1| unnamed protein product [Mus musculus]    475   e-132
gi|10439092|dbj|BAB15429.1| unnamed protein product [Homo sapiens]    451   e-125
gi|7506920|pir||T23707 hypothetical protein T01H8.5 - Caenorhabd...   443   e-122
gi|33112467|sp|Q93971|TRPG_CAEEL Transient receptor potential ch...   443   e-122
gi|32563751|ref|NP_492315.3| abnormal GONad development GON-2, p...   443   e-122
gi|39595604|emb|CAE67105.1| Hypothetical protein CBG12518 [Caeno...   442   e-122
gi|24412720|emb|CAC81668.1| putative TRP homologous cation chann...   442   e-122
gi|50761777|ref|XP_424831.1| PREDICTED: similar to long transien...   426   e-117
gi|33235694|dbj|BAC80204.1| melastatin 1 splicing variant [Homo ...   410   e-112
gi|3243075|gb|AAC80000.1| melastatin 1 [Homo sapiens]                 410   e-112
gi|21450859|ref|NP_002411.2| transient receptor potential cation...   410   e-112
gi|33235686|dbj|BAC80200.1| melastatin 1 [Homo sapiens]               410   e-112
gi|26342260|dbj|BAC34792.1| unnamed protein product [Mus musculus]    409   e-112
gi|33235688|dbj|BAC80201.1| melastatin 1 [Homo sapiens]               407   e-112
gi|50752088|ref|XP_422646.1| PREDICTED: similar to transient rec...   405   e-111
gi|34862088|ref|XP_219902.2| similar to hypothetical protein [Ra...   404   e-111
gi|47210870|emb|CAF92603.1| unnamed protein product [Tetraodon n...   400   e-109
gi|21314671|ref|NP_060106.2| transient receptor potential cation...   379   e-103
gi|32487286|emb|CAE05940.1| transient receptor potential ion cha...   374   e-101
gi|7020006|dbj|BAA90958.1| unnamed protein product [Homo sapiens]     373   e-101
gi|47208258|emb|CAF91479.1| unnamed protein product [Tetraodon n...   355   4e-96
gi|37790770|gb|AAR03491.1| M6-kinase 1 [Homo sapiens]                 354   1e-95
gi|34856313|ref|XP_341869.1| similar to transient receptor poten...   338   5e-91
gi|37790772|gb|AAR03492.1| M6-kinase 2 [Homo sapiens]                 338   8e-91
gi|16416145|emb|CAD01139.1| putative TRP cation channel [Homo sa...   332   6e-89
gi|7768779|dbj|BAA95563.1| transient receptor potential-related ...   330   1e-88
gi|4507689|ref|NP_003298.1| transient receptor potential cation ...   330   1e-88
gi|47575895|ref|NP_001001188.1| transient receptor potential cat...   330   1e-88
gi|34852365|ref|XP_228069.2| similar to transient receptor poten...   322   4e-86
gi|31083376|ref|NP_612174.1| transient receptor potential cation...   319   4e-85
gi|6723520|emb|CAB66342.1| LTRPC5 protein [Homo sapiens]              315   7e-84
gi|11225266|ref|NP_055370.1| transient receptor potential cation...   314   1e-83
gi|34861772|ref|XP_344980.1| similar to MLSN1- and TRP-related p...   312   4e-83
gi|8777450|dbj|BAA96877.1| MLSN1- and TRP-related protein 1 [Mus...   311   6e-83
gi|12383054|ref|NP_064673.1| transient receptor potential cation...   311   6e-83
gi|11967809|emb|CAC19456.1| Ltrpc5 protein [Mus musculus]             311   6e-83
gi|11967810|emb|CAC19457.1| Ltrpc5 protein [Mus musculus]             311   6e-83
gi|50747866|ref|XP_421023.1| PREDICTED: similar to transient rec...   308   5e-82
gi|20537335|sp|Q9HCF6|TRL3_HUMAN Long transient receptor potenti...   303   2e-80
gi|29171322|ref|NP_780339.1| transient receptor potential cation...   302   5e-80
gi|31335335|gb|AAP44475.1| transient receptor potential cation c...   297   1e-78
gi|31335145|gb|AAP44477.1| transient receptor potential cation c...   296   4e-78
gi|11993700|gb|AAG42856.1| melastatin 2 [Homo sapiens]                289   4e-76
gi|33417094|gb|AAH56004.1| LOC398685 protein [Xenopus laevis]         286   2e-75
gi|26340044|dbj|BAC33685.1| unnamed protein product [Mus musculus]    286   2e-75
gi|26449301|dbj|BAC41778.1| hypothetical protein [Macaca fascicu...   283   3e-74
gi|47228179|emb|CAG07574.1| unnamed protein product [Tetraodon n...   281   1e-73
gi|45709181|gb|AAH67733.1| TRPM3 protein [Homo sapiens]               280   3e-73
gi|34783897|gb|AAH22454.2| TRPM3 protein [Homo sapiens]               280   3e-73
gi|26342364|dbj|BAC34844.1| unnamed protein product [Mus musculus]    279   3e-73
gi|26342304|dbj|BAC34814.1| unnamed protein product [Mus musculus]    279   3e-73
gi|26351079|dbj|BAC39176.1| unnamed protein product [Mus musculus]    279   3e-73
gi|15617229|gb|AAL02142.1| TRP-related cation influx channel [Ho...   277   1e-72
gi|7019879|dbj|BAA90907.1| unnamed protein product [Homo sapiens]     277   1e-72
gi|3047242|gb|AAC13683.1| melastatin [Mus musculus]                   274   1e-71
gi|38086815|ref|XP_358370.1| transient receptor potential cation...   273   2e-71
gi|19570794|dbj|BAB86335.1| LTRPC6 [Homo sapiens]                     265   7e-69
gi|32966583|gb|AAP92167.1| transient receptor potential subfamil...   265   7e-69
gi|21361691|ref|NP_076985.3| transient receptor potential cation...   265   9e-69
gi|19527416|ref|NP_599013.1| transient receptor potential cation...   262   6e-68
gi|19705471|ref|NP_599198.1| cold/menthol receptor 1 [Rattus nor...   261   1e-67
gi|12852708|dbj|BAB29509.1| unnamed protein product [Mus musculus]    261   1e-67
gi|50750125|ref|XP_421881.1| PREDICTED: similar to transient rec...   260   2e-67
gi|26330492|dbj|BAC28976.1| unnamed protein product [Mus musculus]    249   3e-64
gi|30046835|gb|AAH51024.1| Similar to transient receptor potenti...   248   1e-63
gi|12052728|emb|CAB66480.1| hypothetical protein [Homo sapiens]       241   1e-61
gi|34862086|ref|XP_342036.1| similar to transient receptor poten...   241   1e-61
gi|47226315|emb|CAG09283.1| unnamed protein product [Tetraodon n...   236   3e-60
gi|37590435|gb|AAH58632.1| Trpm4 protein [Mus musculus]               224   1e-56
gi|45935368|ref|NP_996831.1| transient receptor potential cation...   215   6e-54
gi|33235690|dbj|BAC80202.1| melastatin 1 splicing variant [Homo ...   215   6e-54
gi|49118014|gb|AAH72955.1| LOC398685 protein [Xenopus laevis]         210   3e-52
gi|47230747|emb|CAF99940.1| unnamed protein product [Tetraodon n...   207   2e-51
gi|9929957|dbj|BAB12135.1| hypothetical protein [Macaca fascicul...   204   1e-50
gi|28385940|gb|AAH46472.1| Trpm4 protein [Mus musculus]               198   8e-49
gi|37790774|gb|AAR03493.1| M6-kinase 3 [Homo sapiens]                 198   8e-49
gi|16553674|dbj|BAB71558.1| unnamed protein product [Homo sapiens]    197   2e-48
gi|47215300|emb|CAG01605.1| unnamed protein product [Tetraodon n...   169   5e-40
gi|10433044|dbj|BAB13895.1| unnamed protein product [Homo sapiens]    167   3e-39
gi|28479403|ref|XP_145667.2| similar to transient receptor poten...   127   2e-27
gi|47205617|emb|CAF94442.1| unnamed protein product [Tetraodon n...   108   8e-22
gi|47210869|emb|CAF92602.1| unnamed protein product [Tetraodon n...   106   5e-21
gi|12654599|gb|AAH01135.1| TRPM8 protein [Homo sapiens] >gnl|BL_...   104   2e-20
gi|47230746|emb|CAF99939.1| unnamed protein product [Tetraodon n...   103   3e-20
gi|42742434|gb|AAS45275.1| short transient receptor potential su...   102   8e-20
gi|33636395|dbj|BAC81770.1| transient receptor potential cation ...   101   2e-19
gi|29612563|gb|AAH49993.1| Trpm4 protein [Mus musculus]               101   2e-19
gi|10566461|dbj|BAB15808.1| melastatin like 2 [Rattus norvegicus]      97   4e-18
gi|34856318|ref|XP_341870.1| similar to transient receptor poten...    80   3e-13
gi|28385937|gb|AAH46537.1| Trpm4 protein [Mus musculus]                73   6e-11
gi|33636393|dbj|BAC81769.1| transient receptor potential cation ...    70   3e-10
gi|47077801|dbj|BAD18773.1| unnamed protein product [Homo sapiens]     65   1e-08
gi|39585119|emb|CAE62770.1| Hypothetical protein CBG06939 [Caeno...    60   6e-07
gi|23123868|ref|ZP_00105901.1| hypothetical protein [Nostoc punc...    53   5e-05
gi|17229066|ref|NP_485614.1| unknown protein [Nostoc sp. PCC 712...    52   1e-04
gi|16444883|emb|CAC81659.1| putative TRP homologous cation chann...    50   3e-04
gi|17552730|ref|NP_499021.1| CEll Death abnormality CED-11, TRP ...    50   3e-04
gi|34849478|gb|AAH58286.1| Unknown (protein for IMAGE:6673722) [...    48   0.002
gi|34555944|emb|CAA94592.2| Hypothetical protein F13B12.3 [Caeno...    45   0.014
gi|34330186|ref|NP_899192.1| transient receptor potential cation...    44   0.025
gi|171959|gb|AAA34783.1| myosin-like protein                           41   0.21
gi|6322948|ref|NP_013021.1| Mlp proteins restrict telomere lengt...    41   0.21
gi|33300056|emb|CAE17694.1| Hypothetical protein C12D8.13 [Caeno...    41   0.27
gi|15899050|ref|NP_343655.1| NADH oxidase [Sulfolobus solfataric...    40   0.36
gi|26553606|ref|NP_757540.1| predicted cytoskeletal protein [Myc...    40   0.36
gi|39581476|emb|CAE68006.1| Hypothetical protein CBG13617 [Caeno...    40   0.36
gi|17510427|ref|NP_493429.1| predicted CDS, mechanosensory trans...    39   0.79
gi|4885583|ref|NP_005397.1| Rho-associated, coiled-coil containi...    39   0.79
gi|17998549|ref|NP_523483.1| CG11020-PA [Drosophila melanogaster...    39   0.79
gi|47605987|sp|P61584|ROC1_PANTR Rho-associated protein kinase 1...    39   0.79
gi|50731137|ref|XP_417184.1| PREDICTED: similar to putative capa...    39   0.79
gi|45552223|ref|NP_995634.1| CG11020-PB [Drosophila melanogaster...    39   0.79
gi|47222552|emb|CAG02917.1| unnamed protein product [Tetraodon n...    39   1.0
gi|47221103|emb|CAG12797.1| unnamed protein product [Tetraodon n...    39   1.0
gi|23509023|ref|NP_701691.1| hypothetical protein [Plasmodium fa...    39   1.4
gi|23509279|ref|NP_701946.1| hypothetical protein [Plasmodium fa...    39   1.4
gi|31203635|ref|XP_310766.1| ENSANGP00000014854 [Anopheles gambi...    39   1.4
gi|12802208|gb|AAK07770.1| unknown [Babesia bovis]                     38   1.8
gi|39591656|emb|CAE71233.1| Hypothetical protein CBG18103 [Caeno...    38   1.8
gi|48095512|ref|XP_392309.1| similar to CG11020-PB [Apis mellifera]    38   1.8
gi|11120728|ref|NP_068539.1| ion channel protein [Rattus norvegi...    38   1.8
gi|37359685|emb|CAE47766.1| SI:bZ1P14.9 (novel protein similar t...    38   1.8
gi|20988520|gb|AAH30436.1| 8430438L13Rik protein [Mus musculus]        38   1.8
gi|2133394|pir||S61535 nucleotide-binding head-stalk protein 183...    38   1.8
gi|29248170|gb|EAA39711.1| GLP_741_55154_50292 [Giardia lamblia ...    38   1.8
gi|31197759|ref|XP_307827.1| ENSANGP00000017234 [Anopheles gambi...    38   2.3
gi|32564336|ref|NP_498881.2| transient Receptor Potential channe...    38   2.3
gi|33304289|gb|AAQ02629.1| transient receptor potential channel ...    38   2.3
gi|7447160|pir||JC5807 trp3 protein - rat                              38   2.3
gi|85171|pir||JU0092 trp protein - fruit fly (Drosophila melanog...    38   2.3
gi|1620935|emb|CAB02410.1| Trp protein [Calliphora vicina]             38   2.3
gi|1174798|sp|P19334|TRP_DROME Transient receptor potential prot...    38   2.3
gi|17136554|ref|NP_476768.1| CG7875-PA [Drosophila melanogaster]...    38   2.3
gi|6755889|ref|NP_036165.1| transient receptor potential cation ...    38   2.3
gi|85170|pir||JN0015 trp protein - fruit fly (Drosophila melanog...    38   2.3
gi|600514|gb|AAA56928.1| photoreceptor membrane-associated protein     38   2.3
gi|42740995|gb|AAS44576.1| TRP2 ion channel [Alouatta belzebul]        38   2.3
gi|42740997|gb|AAS44577.1| TRP2 ion channel [Alouatta palliata]        38   2.3
gi|42740999|gb|AAS44578.1| TRP2 ion channel [Alouatta seniculus]       38   2.3
gi|630741|pir||S44873 ZC21.2 protein - Caenorhabditis elegans          38   2.3
gi|50752552|ref|XP_422827.1| PREDICTED: similar to Myosin heavy ...    37   3.0
gi|15791066|ref|NP_280890.1| N-ethylammeline chlorohydrolase; Tr...    37   3.0
gi|9967846|emb|CAC06051.2| putative capacitative calcium entry c...    37   3.0
gi|26328139|dbj|BAC27810.1| unnamed protein product [Mus musculus]     37   3.0
gi|4507687|ref|NP_003296.1| transient receptor potential cation ...    37   3.0
gi|47933429|gb|AAT39342.1| calcium transporter 2 [Oikopleura dio...    37   3.0
gi|5730102|ref|NP_004612.2| transient receptor potential cation ...    37   3.0
gi|7494300|pir||G71611 hypothetical protein PFB0560w - malaria p...    37   3.0
gi|39582797|emb|CAE74260.1| Hypothetical protein CBG21950 [Caeno...    37   3.0
gi|50746873|ref|XP_426322.1| PREDICTED: similar to Short transie...    37   3.0
gi|9507207|ref|NP_062383.1| transient receptor potential cation ...    37   3.0
gi|26348643|dbj|BAC37961.1| unnamed protein product [Mus musculus]     37   3.0
gi|23593303|ref|NP_473041.2| hypothetical protein [Plasmodium fa...    37   3.0
gi|33304274|gb|AAQ02628.1| transient receptor potential channel ...    37   3.0
gi|33304334|gb|AAQ02632.1| transient receptor potential channel ...    37   3.0
gi|33304319|gb|AAQ02631.1| transient receptor potential channel ...    37   3.0
gi|11095639|gb|AAG29950.1| transient receptor potential channel ...    37   3.9
gi|6755887|ref|NP_035774.1| transient receptor potential cation ...    37   3.9
gi|12018338|ref|NP_072160.1| transient receptor potential cation...    37   3.9
gi|34392424|dbj|BAC82538.1| trp6 [Cavia porcellus]                     37   3.9
gi|23509391|ref|NP_702058.1| hypothetical protein [Plasmodium fa...    37   3.9
gi|9967888|emb|CAC06427.1| TRPC6 cation channel, putative altern...    37   3.9
gi|9967886|emb|CAC06426.1| TRPC6 cation channel, putative altern...    37   3.9
gi|4324938|gb|AAD17195.1| transient receptor potential 2 [Mus mu...    37   3.9
gi|33304304|gb|AAQ02630.1| transient receptor potential channel ...    37   3.9
gi|11095641|gb|AAG29951.1| transient receptor potential channel ...    37   3.9
gi|34392422|dbj|BAC82537.1| trp3 [Cavia porcellus]                     37   5.1
gi|23612336|ref|NP_703916.1| hypothetical protein [Plasmodium fa...    36   6.7
gi|18376629|emb|CAD19069.1| short transient receptor potential c...    36   6.7
gi|9966865|ref|NP_065122.1| putative capacitative calcium channe...    36   6.7
gi|19684076|gb|AAH25988.1| Leucine zipper transcription factor-l...    36   8.8
gi|23612199|ref|NP_703779.1| hypothetical protein [Plasmodium fa...    36   8.8
gi|8980369|emb|CAB96873.1| leucine zipper transcription factor-l...    36   8.8
gi|46134013|ref|XP_389322.1| hypothetical protein FG09146.1 [Gib...    36   8.8
gi|14588885|emb|CAA70302.1| asparagine-rich protein [Plasmodium ...    36   8.8
gi|23480634|gb|EAA17141.1| hypothetical protein [Plasmodium yoel...    36   8.8
gi|34877522|ref|XP_341410.1| similar to 8430438L13Rik protein [R...    36   8.8
gi|16799897|ref|NP_470165.1| similar to transport protein (trunc...    36   8.8
gi|33086618|gb|AAP92621.1| Ac2-154 [Rattus norvegicus]                 36   8.8
gi|23508404|ref|NP_701073.1| hypothetical protein [Plasmodium fa...    36   8.8
gi|13592049|ref|NP_112360.1| Rho-associated kinase beta [Rattus ...    36   8.8
gi|23491382|gb|EAA22927.1| hypothetical protein [Plasmodium yoel...    36   8.8


>gi|7504163|pir||T22644 hypothetical protein F54D1.5 - Caenorhabditis
            elegans
          Length = 1400

 Score = 2686 bits (6962), Expect = 0.0
 Identities = 1327/1363 (97%), Positives = 1327/1363 (97%)
 Frame = +1

Query: 1    MCNANTVHSISSFRSDHLSRKSTHKFLDNPNLFAIELTEKLSPPWIENTFEKRECIRFAA 180
            MCNANTVHSISSFRSDHLSRKSTHKFLDNPNLFAIELTEKLSPPWIENTFEKRECIRFAA
Sbjct: 38   MCNANTVHSISSFRSDHLSRKSTHKFLDNPNLFAIELTEKLSPPWIENTFEKRECIRFAA 97

Query: 181  LPKDPERCGCGRPLSAHTPASTFFSTLPVHLLEKEQQTWTIANNTQTSTTDAFGTIVFQG 360
            LPKDPERCGCGRPLSAHTPASTFFSTLPVHLLEKEQQTWTIANNTQTSTTDAFGTIVFQG
Sbjct: 98   LPKDPERCGCGRPLSAHTPASTFFSTLPVHLLEKEQQTWTIANNTQTSTTDAFGTIVFQG 157

Query: 361  GAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKG 540
            GAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKG
Sbjct: 158  GAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKG 217

Query: 541  MLKAAQTTGAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLI 720
            MLKAAQTTGAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLI
Sbjct: 218  MLKAAQTTGAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLI 277

Query: 721  RQNEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN 900
            RQNEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN
Sbjct: 278  RQNEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN 337

Query: 901  GRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFA 1080
            GRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFA
Sbjct: 338  GRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFA 397

Query: 1081 AEVGEKLRNLIKMVFPETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQ 1260
            AEVGEKLRNLIKMVFPETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQ
Sbjct: 398  AEVGEKLRNLIKMVFPETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQ 457

Query: 1261 KQNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLEN 1440
            KQNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLEN
Sbjct: 458  KQNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLEN 517

Query: 1441 GVSMKNFLSINRLENLYNMDDINSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNA 1620
            GVSMKNFLSINRLENLYNMDDINSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNA
Sbjct: 518  GVSMKNFLSINRLENLYNMDDINSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNA 577

Query: 1621 FQLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPF 1800
            FQLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPF
Sbjct: 578  FQLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPF 637

Query: 1801 NDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDN 1980
            NDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDN
Sbjct: 638  NDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDN 697

Query: 1981 AVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQIL 2160
            AVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQIL
Sbjct: 698  AVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQIL 757

Query: 2161 LAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESI 2340
            LAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESI
Sbjct: 758  LAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESI 817

Query: 2341 TSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXXFKREPQL 2520
            TSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKN              FKREPQL
Sbjct: 818  TSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNSGVASVYGSASSMMFKREPQL 877

Query: 2521 NKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVE 2700
            NKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVE
Sbjct: 878  NKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVE 937

Query: 2701 HIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFS 2880
            HIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFS
Sbjct: 938  HIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFS 997

Query: 2881 NVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKD 3060
            NVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKD
Sbjct: 998  NVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKD 1057

Query: 3061 WHWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLMXXXXXXXXXXXXX 3240
            WHWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLM
Sbjct: 1058 WHWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLMVIFLLVANILLLN 1117

Query: 3241 XXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRR 3420
                     YNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRR
Sbjct: 1118 LLIAIFNNIYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRR 1177

Query: 3421 PDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTKEPLSVTDLTELTCQ 3600
            PDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTKEPLSVTDLTELTCQ
Sbjct: 1178 PDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTKEPLSVTDLTELTCQ 1237

Query: 3601 RVHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEV 3780
            RVHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEV
Sbjct: 1238 RVHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEV 1297

Query: 3781 PKITKTLIDCHLSPVSIEDRLATRSPLLANLQRDHTLRKYDDANFQPGKLQRRARLHSSS 3960
            PKITKTLIDCHLSPVSIEDRLATRSPLLANLQRDHTLRKYDDANFQPGKLQRRARLHSSS
Sbjct: 1298 PKITKTLIDCHLSPVSIEDRLATRSPLLANLQRDHTLRKYDDANFQPGKLQRRARLHSSS 1357

Query: 3961 CSISQDMKEMKTSMSSRNLKREDSGEITTSSHGGYDSDVSGPD 4089
            CSISQDMKEMKTSMSSRNLKREDSGEITTSSHGGYDSDVSGPD
Sbjct: 1358 CSISQDMKEMKTSMSSRNLKREDSGEITTSSHGGYDSDVSGPD 1400


>gi|15718227|emb|CAB00861.2| C. elegans GTL-2 protein (corresponding
            sequence F54D1.5) [Caenorhabditis elegans]
          Length = 1363

 Score = 2686 bits (6962), Expect = 0.0
 Identities = 1327/1363 (97%), Positives = 1327/1363 (97%)
 Frame = +1

Query: 1    MCNANTVHSISSFRSDHLSRKSTHKFLDNPNLFAIELTEKLSPPWIENTFEKRECIRFAA 180
            MCNANTVHSISSFRSDHLSRKSTHKFLDNPNLFAIELTEKLSPPWIENTFEKRECIRFAA
Sbjct: 1    MCNANTVHSISSFRSDHLSRKSTHKFLDNPNLFAIELTEKLSPPWIENTFEKRECIRFAA 60

Query: 181  LPKDPERCGCGRPLSAHTPASTFFSTLPVHLLEKEQQTWTIANNTQTSTTDAFGTIVFQG 360
            LPKDPERCGCGRPLSAHTPASTFFSTLPVHLLEKEQQTWTIANNTQTSTTDAFGTIVFQG
Sbjct: 61   LPKDPERCGCGRPLSAHTPASTFFSTLPVHLLEKEQQTWTIANNTQTSTTDAFGTIVFQG 120

Query: 361  GAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKG 540
            GAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKG
Sbjct: 121  GAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKG 180

Query: 541  MLKAAQTTGAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLI 720
            MLKAAQTTGAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLI
Sbjct: 181  MLKAAQTTGAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLI 240

Query: 721  RQNEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN 900
            RQNEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN
Sbjct: 241  RQNEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN 300

Query: 901  GRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFA 1080
            GRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFA
Sbjct: 301  GRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFA 360

Query: 1081 AEVGEKLRNLIKMVFPETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQ 1260
            AEVGEKLRNLIKMVFPETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQ
Sbjct: 361  AEVGEKLRNLIKMVFPETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQ 420

Query: 1261 KQNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLEN 1440
            KQNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLEN
Sbjct: 421  KQNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLEN 480

Query: 1441 GVSMKNFLSINRLENLYNMDDINSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNA 1620
            GVSMKNFLSINRLENLYNMDDINSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNA
Sbjct: 481  GVSMKNFLSINRLENLYNMDDINSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNA 540

Query: 1621 FQLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPF 1800
            FQLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPF
Sbjct: 541  FQLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPF 600

Query: 1801 NDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDN 1980
            NDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDN
Sbjct: 601  NDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDN 660

Query: 1981 AVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQIL 2160
            AVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQIL
Sbjct: 661  AVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQIL 720

Query: 2161 LAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESI 2340
            LAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESI
Sbjct: 721  LAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESI 780

Query: 2341 TSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXXFKREPQL 2520
            TSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKN              FKREPQL
Sbjct: 781  TSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNSGVASVYGSASSMMFKREPQL 840

Query: 2521 NKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVE 2700
            NKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVE
Sbjct: 841  NKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVE 900

Query: 2701 HIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFS 2880
            HIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFS
Sbjct: 901  HIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFS 960

Query: 2881 NVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKD 3060
            NVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKD
Sbjct: 961  NVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKD 1020

Query: 3061 WHWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLMXXXXXXXXXXXXX 3240
            WHWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLM
Sbjct: 1021 WHWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLMVIFLLVANILLLN 1080

Query: 3241 XXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRR 3420
                     YNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRR
Sbjct: 1081 LLIAIFNNIYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRR 1140

Query: 3421 PDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTKEPLSVTDLTELTCQ 3600
            PDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTKEPLSVTDLTELTCQ
Sbjct: 1141 PDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTKEPLSVTDLTELTCQ 1200

Query: 3601 RVHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEV 3780
            RVHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEV
Sbjct: 1201 RVHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEV 1260

Query: 3781 PKITKTLIDCHLSPVSIEDRLATRSPLLANLQRDHTLRKYDDANFQPGKLQRRARLHSSS 3960
            PKITKTLIDCHLSPVSIEDRLATRSPLLANLQRDHTLRKYDDANFQPGKLQRRARLHSSS
Sbjct: 1261 PKITKTLIDCHLSPVSIEDRLATRSPLLANLQRDHTLRKYDDANFQPGKLQRRARLHSSS 1320

Query: 3961 CSISQDMKEMKTSMSSRNLKREDSGEITTSSHGGYDSDVSGPD 4089
            CSISQDMKEMKTSMSSRNLKREDSGEITTSSHGGYDSDVSGPD
Sbjct: 1321 CSISQDMKEMKTSMSSRNLKREDSGEITTSSHGGYDSDVSGPD 1363


>gi|39593744|emb|CAE62037.1| Hypothetical protein CBG06053
            [Caenorhabditis briggsae]
          Length = 1365

 Score = 2503 bits (6487), Expect = 0.0
 Identities = 1222/1365 (89%), Positives = 1282/1365 (93%), Gaps = 2/1365 (0%)
 Frame = +1

Query: 1    MCNANTVHSISSFRSDHLSRKSTHKFLDNPNLFAIELTEKLSPPWIENTFEKRECIRFAA 180
            +CNANTVHSISSFRSDHLSRKSTHK L+NPNLFAIELTEKLSPPWIENTFEKREC+RF A
Sbjct: 1    VCNANTVHSISSFRSDHLSRKSTHKLLENPNLFAIELTEKLSPPWIENTFEKRECVRFTA 60

Query: 181  LPKDPERCGCGRPLSAHTPASTFFSTLPVHLLEKEQQTWTIANNTQTSTTDAFGTIVFQG 360
              KD ERCGCGRPL+AH+ AS  F TLP  +++KEQ+ WTIANNTQTSTTDAFGTIVFQG
Sbjct: 61   QSKDAERCGCGRPLAAHSSASRLFYTLPYQIIDKEQEVWTIANNTQTSTTDAFGTIVFQG 120

Query: 361  GAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKG 540
            GAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFEL+ERLGRLFRKG
Sbjct: 121  GAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELQERLGRLFRKG 180

Query: 541  MLKAAQTTGAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLI 720
            MLKAAQTTGAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLI
Sbjct: 181  MLKAAQTTGAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLI 240

Query: 721  RQNEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN 900
            R+NEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIAT+GCN
Sbjct: 241  RKNEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATYGCN 300

Query: 901  GRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFA 1080
            GRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAAD+ISFAARYIN+DGTFA
Sbjct: 301  GRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADLISFAARYINTDGTFA 360

Query: 1081 AEVGEKLRNLIKMVFPETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQ 1260
            AEVGEKL+NLIKMVFPE+DQE M  KITECVIRDDLLRIFRYG+EEEEDVDFVILSTVLQ
Sbjct: 361  AEVGEKLKNLIKMVFPESDQEGMLSKITECVIRDDLLRIFRYGEEEEEDVDFVILSTVLQ 420

Query: 1261 KQNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLEN 1440
            KQNLPPDEQLALTLSWNRVDLAKSCLFSNGRKW SDVLEKAMNDALYWDRVDFVECLLEN
Sbjct: 421  KQNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWPSDVLEKAMNDALYWDRVDFVECLLEN 480

Query: 1441 GVSMKNFLSINRLENLYNMDDINSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNA 1620
            GVSMKNFL+INRLENLYNMDD+NSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNA
Sbjct: 481  GVSMKNFLTINRLENLYNMDDVNSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNA 540

Query: 1621 FQLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPF 1800
            FQLYYTSRSFKGKYDRYKR+NQSSYF+RKRKIVQKELFKKKSDDQI+++ EEDFSF+YPF
Sbjct: 541  FQLYYTSRSFKGKYDRYKRLNQSSYFYRKRKIVQKELFKKKSDDQIDESSEEDFSFSYPF 600

Query: 1801 NDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDN 1980
            NDLLIWAVLTSRH MA+CMW+HGEDAMAKCL+AIRLYKATAKIAEDEYLDVEEAKRLFDN
Sbjct: 601  NDLLIWAVLTSRHEMAKCMWIHGEDAMAKCLVAIRLYKATAKIAEDEYLDVEEAKRLFDN 660

Query: 1981 AVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQIL 2160
            AVKCREDAIEL+DQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQIL
Sbjct: 661  AVKCREDAIELVDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQIL 720

Query: 2161 LAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESI 2340
            LAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKH+KTARLLSEET E +PYPRESI
Sbjct: 721  LAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHAKTARLLSEETQEDIPYPRESI 780

Query: 2341 TSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXXFKREPQL 2520
            TSTTSNRYRY KGPEEQKETLLEKG+Y KKVTIISSRKN              FKR+PQL
Sbjct: 781  TSTTSNRYRYPKGPEEQKETLLEKGNYAKKVTIISSRKNSGVASVYGSASSMMFKRDPQL 840

Query: 2521 NKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVE 2700
            +KFE+FRAFYS+PITKFWSWCIAFLIFL TQTCILLLETSLKPSKYEWI  +YTVTLSVE
Sbjct: 841  SKFEKFRAFYSAPITKFWSWCIAFLIFLITQTCILLLETSLKPSKYEWILLVYTVTLSVE 900

Query: 2701 HIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFS 2880
            H+RKL+TSEGSRINEK+KVFYAKWYNIWTSAALLFFL GYGFRLVPM+RHSWGRVLLS S
Sbjct: 901  HMRKLLTSEGSRINEKIKVFYAKWYNIWTSAALLFFLFGYGFRLVPMFRHSWGRVLLSIS 960

Query: 2881 NVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKD 3060
            NVLFYMK FEYLSVHPLLGPYIQMAAKMVWSMCYI VLLLVPLMAFGVNRQALTEP +KD
Sbjct: 961  NVLFYMKTFEYLSVHPLLGPYIQMAAKMVWSMCYIVVLLLVPLMAFGVNRQALTEPKIKD 1020

Query: 3061 WHWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLMXXXXXXXXXXXXX 3240
            W+WLLVRNIFYKPYFMLYGEVYAGEIDTCGDEG RCFPGYFIPPLLM
Sbjct: 1021 WNWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGTRCFPGYFIPPLLMVVFLLVANILLLN 1080

Query: 3241 XXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLR- 3417
                     YNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDY++NLR
Sbjct: 1081 LLIAIFNNIYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYIWNLRS 1140

Query: 3418 -RPDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTKEPLSVTDLTELT 3594
             RPDTKRFRSEHSIK SVTEDEMKR+QDFEEDCIDTLTR R+LKL+TKEPL++TDLTELT
Sbjct: 1141 KRPDTKRFRSEHSIKWSVTEDEMKRMQDFEEDCIDTLTRTRRLKLDTKEPLNMTDLTELT 1200

Query: 3595 CQRVHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSI 3774
            C+RVHDLMQENFLLKSRVYDIETKIDHI+NSSDEVV ILKNKK+SQNFAAS LSLP+TSI
Sbjct: 1201 CERVHDLMQENFLLKSRVYDIETKIDHIANSSDEVVLILKNKKMSQNFAASCLSLPETSI 1260

Query: 3775 EVPKITKTLIDCHLSPVSIEDRLATRSPLLANLQRDHTLRKYDDANFQPGKLQRRARLHS 3954
            EVPK+TK LID HLSPV IE+RLATRSPLLANL RDHTLRKYDDANFQ G LQRR RLHS
Sbjct: 1261 EVPKLTKPLIDYHLSPVVIEERLATRSPLLANLHRDHTLRKYDDANFQAGNLQRRTRLHS 1320

Query: 3955 SSCSISQDMKEMKTSMSSRNLKREDSGEITTSSHGGYDSDVSGPD 4089
            SSCSISQDMKEM+TS SSRNLKR+DS E+T SSHGGYDSD+SGPD
Sbjct: 1321 SSCSISQDMKEMRTSASSRNLKRQDSEELTVSSHGGYDSDISGPD 1365


>gi|32565923|ref|NP_502118.2| Gon-Two Like, TRP subfamily (gtl-2)
            [Caenorhabditis elegans]
 gi|24412716|emb|CAC81666.1| putative TRP homologous cation channel
            [Caenorhabditis elegans]
          Length = 1122

 Score = 2200 bits (5701), Expect = 0.0
 Identities = 1086/1122 (96%), Positives = 1086/1122 (96%)
 Frame = +1

Query: 724  QNEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCNG 903
            QNEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCNG
Sbjct: 1    QNEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCNG 60

Query: 904  RKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAA 1083
            RKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAA
Sbjct: 61   RKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAA 120

Query: 1084 EVGEKLRNLIKMVFPETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQK 1263
            EVGEKLRNLIKMVFPETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQK
Sbjct: 121  EVGEKLRNLIKMVFPETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQK 180

Query: 1264 QNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENG 1443
            QNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENG
Sbjct: 181  QNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENG 240

Query: 1444 VSMKNFLSINRLENLYNMDDINSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNAF 1623
            VSMKNFLSINRLENLYNMDDINSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNAF
Sbjct: 241  VSMKNFLSINRLENLYNMDDINSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNAF 300

Query: 1624 QLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPFN 1803
            QLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPFN
Sbjct: 301  QLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPFN 360

Query: 1804 DLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDNA 1983
            DLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDNA
Sbjct: 361  DLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDNA 420

Query: 1984 VKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQILL 2163
            VKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQILL
Sbjct: 421  VKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQILL 480

Query: 2164 AELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESIT 2343
            AELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESIT
Sbjct: 481  AELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESIT 540

Query: 2344 STTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXXFKREPQLN 2523
            STTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKN              FKREPQLN
Sbjct: 541  STTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNSGVASVYGSASSMMFKREPQLN 600

Query: 2524 KFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVEH 2703
            KFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVEH
Sbjct: 601  KFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVEH 660

Query: 2704 IRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFSN 2883
            IRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFSN
Sbjct: 661  IRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFSN 720

Query: 2884 VLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKDW 3063
            VLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKDW
Sbjct: 721  VLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKDW 780

Query: 3064 HWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLMXXXXXXXXXXXXXX 3243
            HWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLM
Sbjct: 781  HWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLMVIFLLVANILLLNL 840

Query: 3244 XXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRRP 3423
                    YNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRRP
Sbjct: 841  LIAIFNNIYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRRP 900

Query: 3424 DTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTKEPLSVTDLTELTCQR 3603
            DTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTKEPLSVTDLTELTCQR
Sbjct: 901  DTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTKEPLSVTDLTELTCQR 960

Query: 3604 VHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEVP 3783
            VHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEVP
Sbjct: 961  VHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEVP 1020

Query: 3784 KITKTLIDCHLSPVSIEDRLATRSPLLANLQRDHTLRKYDDANFQPGKLQRRARLHSSSC 3963
            KITKTLIDCHLSPVSIEDRLATRSPLLANLQRDHTLRKYDDANFQPGKLQRRARLHSSSC
Sbjct: 1021 KITKTLIDCHLSPVSIEDRLATRSPLLANLQRDHTLRKYDDANFQPGKLQRRARLHSSSC 1080

Query: 3964 SISQDMKEMKTSMSSRNLKREDSGEITTSSHGGYDSDVSGPD 4089
            SISQDMKEMKTSMSSRNLKREDSGEITTSSHGGYDSDVSGPD
Sbjct: 1081 SISQDMKEMKTSMSSRNLKREDSGEITTSSHGGYDSDVSGPD 1122


>gi|50511021|dbj|BAD32496.1| mKIAA1616 protein [Mus musculus]
          Length = 1718

 Score =  759 bits (1960), Expect = 0.0
 Identities = 433/1221 (35%), Positives = 690/1221 (56%), Gaps = 37/1221 (3%)
 Frame = +1

Query: 133  WIENTFEKRECIRFAALPKDPERCGCGRPLSAHTPASTFFSTLPVHLLEK-------EQQ 291
            WIE  F KREC+      KDP RC CGR +  H   +   S L     E        + +
Sbjct: 75   WIERAFYKRECVHIIPSTKDPHRCCCGRLIGQHVGLTPSISVLQNEKNESRLSRNDIQSE 134

Query: 292  TWTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEAPRLV 471
             W+I+ +TQ S TDAFGTI FQGG H++KA YVR+S+D++P  +++LM K W LE P+L+
Sbjct: 135  KWSISKHTQLSPTDAFGTIEFQGGGHSNKAMYVRVSFDTKPDLLLHLMTKEWQLELPKLL 194

Query: 472  ITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVAKALDEAGISAR 651
            I+VHGG+ NFEL+ +L ++F KG++KAA TTGAWI T G+++GV+RHV  AL +   +++
Sbjct: 195  ISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNTGVIRHVGDALKDH--ASK 252

Query: 652  MRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTV 831
             R +I TIGIAPWG+++ +E LI ++    Y   S +  + + +LN  HS+F+LADNGT
Sbjct: 253  SRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMS-NPMSKLTVLNSMHSHFILADNGTT 311

Query: 832  GRFGADLHLRQNLENHIATFGCN---GRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAI 1002
            G++GA++ LR+ LE HI+    N   G+ VPVV  ++EGG + I+ + +Y+   P +P +
Sbjct: 312  GKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVV 371

Query: 1003 VCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMVF--PETDQEEMFRKITECVI 1176
            VCDGSGRA+DI++F  +Y    G     + ++L   I+  F    T  + +F  + EC+
Sbjct: 372  VCDGSGRASDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMK 431

Query: 1177 RDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCLFSNGRK 1356
            + +L+ +FR G E  +D+D  IL+ +L+  N    +QL+L L+WNRVD+A+S +F  G++
Sbjct: 432  KKELITVFRMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQ 491

Query: 1357 WSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDDINS---AHSVR 1527
            W    LE+AM DAL  DRVDFV+ L+ENGVSM  FL+I+RLE LYN     S    H VR
Sbjct: 492  WPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR 551

Query: 1528 NWMENFDSMDPHTYLTIPMIGQVVEKLMGNAFQLYYTSRSFKGKYDRY---KRINQSSYF 1698
            +  +   ++ P   +++  IG V+E LMG A++  YT + F+  Y      KR
Sbjct: 552  DVKKG--NLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLL 609

Query: 1699 HRKRKIV----QKELFKKKSDDQINDNEEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVH 1866
              +  I     +K   K++ +  I+ ++ E   F +PF++L++WAVL  R  MA   W H
Sbjct: 610  GMEDDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQH 669

Query: 1867 GEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDR 2046
            GE+AMAK L+A +L KA A  A +  +  + ++ L  N+    + A+ELLDQ Y+ D
Sbjct: 670  GEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQL 729

Query: 2047 TLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTA 2226
             ++LL  EL +W N  CL LAV A  + F+AH C Q+LL ++W G L++R  S ++V+
Sbjct: 730  AMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILG 789

Query: 2227 LICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLL 2406
            ++ PP+IL + +K K             + +PY  ++        +   K PEE ++
Sbjct: 790  ILLPPSILSLEFKNK-------------DDMPYMTQA-----QEIHLQEKEPEEPEKPTK 831

Query: 2407 EKGSYTKKVTIISSRKNXXXXXXXXXXXXXXFKREPQLNKFERFRAFYSSPITKFWSWCI 2586
            EK     ++T +  R N                R   + +  +   FY++PI KFW + +
Sbjct: 832  EKDEEDMELTAMLGRSNGESSRKKDEEEVQSRHRLIPVGR--KIYEFYNAPIVKFWFYTL 889

Query: 2587 AFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYA 2766
            A++ +L     I+L++    PS  EWI   Y  TL +E +R+++ SE  ++ +KVKV+
Sbjct: 890  AYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQ 949

Query: 2767 KWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFSNVLFYMKIFEYLSVHPLLGPYI 2946
            +++N+    A+L F VG   RL      S GRV+   + + +Y+++ +   V+  LGPY+
Sbjct: 950  EYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYV 1009

Query: 2947 QMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVY 3126
             M  KM+  M Y  +++LV LM+FGV RQA+  PN ++  W L +NIFY PY+M+YGEV+
Sbjct: 1010 MMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPN-EEPSWKLAKNIFYMPYWMIYGEVF 1068

Query: 3127 AGEID-TCGDEGIR----------CFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYN 3273
            A +ID  CG    R          C  G +I P +M                      +
Sbjct: 1069 ADQIDPPCGQNETREDGKTIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFF 1128

Query: 3274 DSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYL-YNLRRPDTKRFRSEH 3450
            +    S ++W FQRYQ +M +H+ P LPPP  IF+H+     ++    R+ ++ +   ++
Sbjct: 1129 EVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHVCCRWRKHESDQDERDY 1188

Query: 3451 SIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTK--EPLSVT-DLTELTCQRVHDLMQ 3621
             +KL +T+DE+K++ DFEE CI+   R +  + N+   E + VT +  E    R+ ++ +
Sbjct: 1189 GLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNE 1248

Query: 3622 ENFLLKSRVYDIETKIDHISN 3684
                +K+ +  ++ ++  + +
Sbjct: 1249 REHSMKASLQTVDIRLAQLED 1269


>gi|30141363|emb|CAD43605.1| long transient receptor potential channel
            3 [Homo sapiens]
          Length = 1325

 Score =  758 bits (1958), Expect = 0.0
 Identities = 436/1226 (35%), Positives = 688/1226 (55%), Gaps = 37/1226 (3%)
 Frame = +1

Query: 118  KLSPPWIENTFEKRECIRFAALPKDPERCGCGRPLSAHTPASTFFSTLPVHLLEK----- 282
            K    WIE  F KREC+      KDP RC CGR +  H   +   S L     E
Sbjct: 59   KAQKSWIERAFYKRECVHIIPSTKDPHRCCCGRLIGQHVGLTPSISVLQNEKNESRLSRN 118

Query: 283  --EQQTWTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLE 456
              + + W+I+ +TQ S TDAFGTI FQGG H++KA YVR+S+D++P  +++LM K W LE
Sbjct: 119  DIQSEKWSISKHTQLSPTDAFGTIEFQGGGHSNKAMYVRVSFDTKPDLLLHLMTKEWQLE 178

Query: 457  APRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVAKALDEA 636
             P+L+I+VHGG+ NFEL+ +L ++F KG++KAA TTGAWI T G+++GV+RHV  AL +
Sbjct: 179  LPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNTGVIRHVGDALKDH 238

Query: 637  GISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRHSYFLLA 816
              +++ R +I TIGIAPWG+++ +E LI ++    Y   S +  + + +LN  HS+F+LA
Sbjct: 239  --ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMS-NPMSKLTVLNSMHSHFILA 295

Query: 817  DNGTVGRFGADLHLRQNLENHIATFGCN---GRKVPVVCTLLEGGISSINAIHDYVTMKP 987
            DNGT G++GA++ LR+ LE HI+    N   G+ VPVV  ++EGG + I+ + +Y+   P
Sbjct: 296  DNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVALIVEGGPNVISIVLEYLRDTP 355

Query: 988  DIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMVF--PETDQEEMFRKI 1161
             +P +VCDGSGRA+DI++F  +Y    G     + ++L   I+  F    T  + +F  +
Sbjct: 356  PVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIIL 415

Query: 1162 TECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCLF 1341
             EC+ + +L+ +FR G E  +D+D  IL+ +L+  N    +QL+L L+WNRVD+A+S +F
Sbjct: 416  MECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIF 475

Query: 1342 SNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDDINS--- 1512
              G++W    LE+AM DAL  DRVDFV+ L+ENGVSM  FL+I+RLE LYN     S
Sbjct: 476  IYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTL 535

Query: 1513 AHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNAFQLYYTSRSFKGKYDRY---KRIN 1683
             H VR+  +   ++ P   +++  IG V+E LMG A++  YT + F+  Y      KR
Sbjct: 536  YHLVRDVKKG--NLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPK 593

Query: 1684 QSSYFHRKRKIV----QKELFKKKSDDQINDNEEEDFSFAYPFNDLLIWAVLTSRHGMAE 1851
                   +  I     +K   K++ +  I+ ++ E   F +PF++L++WAVL  R  MA
Sbjct: 594  ALKLLGMEDDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMAL 653

Query: 1852 CMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYR 2031
              W HGE+AMAK L+A +L KA A  A +  +  + ++ L  N+    + A+ELLDQ Y+
Sbjct: 654  FFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYK 713

Query: 2032 ADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNV 2211
             D    ++LL  EL +W N  CL LAV A  + F+AH C Q+LL ++W G L++R  S +
Sbjct: 714  QDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGL 773

Query: 2212 RVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQ 2391
            +V+  ++ PP+IL + +K K             + +PY      S     +   K  EE
Sbjct: 774  KVILGILLPPSILSLEFKNK-------------DDMPY-----MSQAQEIHLQEKEAEEP 815

Query: 2392 KETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXXFKREPQLNKFERFRAFYSSPITKF 2571
            ++   EK     ++T +  R N                R   L +  +   FY++PI KF
Sbjct: 816  EKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGR--KIYEFYNAPIVKF 873

Query: 2572 WSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKV 2751
            W + +A++ +L     I+L++    PS  EWI   Y  TL +E +R+++ SE  ++ +KV
Sbjct: 874  WFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKV 933

Query: 2752 KVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFSNVLFYMKIFEYLSVHPL 2931
            KV+  +++N+    A+L F VG   RL      S GRV+   + + +Y+++ +   V+
Sbjct: 934  KVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKY 993

Query: 2932 LGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFML 3111
            LGPY+ M  KM+  M Y  +++LV LM+FGV RQA+  PN ++  W L +NIFY PY+M+
Sbjct: 994  LGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPN-EEPSWKLAKNIFYMPYWMI 1052

Query: 3112 YGEVYAGEID-TCGDEGIR----------CFPGYFIPPLLMXXXXXXXXXXXXXXXXXXX 3258
            YGEV+A +ID  CG    R          C  G +I P +M
Sbjct: 1053 YGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVF 1112

Query: 3259 XXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYL-YNLRRPDTKR 3435
               + +    S ++W FQRYQ +M +H+ P LPPP  IF+H+     +L    R+ ++
Sbjct: 1113 NNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDP 1172

Query: 3436 FRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTK--EPLSVT-DLTELTCQRV 3606
               ++ +KL +T+DE+K++ DFEE CI+   R +  + N+   E + VT +  E    R+
Sbjct: 1173 DERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRL 1232

Query: 3607 HDLMQENFLLKSRVYDIETKIDHISN 3684
             ++ +    +K+ +  ++ ++  + +
Sbjct: 1233 EEVNEREHSMKASLQTVDIRLAQLED 1258


>gi|48104806|ref|XP_395849.1| similar to ENSANGP00000005757 [Apis
            mellifera]
          Length = 1607

 Score =  730 bits (1885), Expect = 0.0
 Identities = 468/1319 (35%), Positives = 707/1319 (53%), Gaps = 67/1319 (5%)
 Frame = +1

Query: 277  EKEQQTWTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLE 456
            EK+++ W+ A NT+   TDA+GTI FQGG H  KAQYVRL+YD+ P  +++L+ + W L
Sbjct: 33   EKDREQWSPAKNTRPFPTDAYGTIEFQGGPHPTKAQYVRLAYDTRPEPIVHLLCREWNLG 92

Query: 457  APRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVAKALDEA 636
             P+L+ITVHGG SNFEL+  L ++ RKG+LKAA+TTGAWI T G ++GV R V  AL
Sbjct: 93   LPKLLITVHGGRSNFELQPTLKKVLRKGLLKAAKTTGAWIFTGGTNTGVTRQVGDALLLE 152

Query: 637  GISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRHSYFLLA 816
               ++ + ++V+IGIAPWG++ +   L+ +   V YD  S S  +   +LN+RH+YFLL
Sbjct: 153  --RSQRQGRVVSIGIAPWGILDKSHELVGRGGEVSYDCLS-SPWSKYAVLNNRHAYFLLV 209

Query: 817  DNGTVGRFGADLHLRQNLENHIATFGCNG---RKVPVVCTLLEGGISSINAIHDYVTMKP 987
            DNGT GR+GA++ LR+ LE +I+           +PVV  ++EGG ++I ++ +YVT  P
Sbjct: 210  DNGTGGRYGAEIVLRRRLEKYISNLKLQPYTHSSIPVVALVIEGGTNTIRSVLEYVTDVP 269

Query: 988  DIPAIVCDGSGRAADIISFAARYINS-DGTFAAEVG------EKLRNLIKMVFPETDQE- 1143
             +P +VCDGSGRAAD+I+F  +Y +  DG      G      E L + IK  F  + ++
Sbjct: 270  PVPVVVCDGSGRAADLIAFMHKYASEGDGENGDIEGPLESMREHLLDTIKRTFKVSAEQA 329

Query: 1144 -EMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVD 1320
             +++ ++ +C  +  L+ +FR  QE  +++D  IL+ + + + L P EQL+L+L WNRVD
Sbjct: 330  SQLYSELLQCTRKKHLITVFRISQERPQELDQTILTALFKSKQLSPAEQLSLSLIWNRVD 389

Query: 1321 LAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMD 1500
            +A+  +F  G+ W    LE+AM  AL  DR+DFV+ LLENGVSM+ FLSI RLE LYN
Sbjct: 390  IARCEIFVYGQNWPPGALEQAMMQALQHDRIDFVKLLLENGVSMRKFLSIPRLEELYNTK 449

Query: 1501 DINSAHSVRNWMENFDSMDPHTYL-TIPMIGQVVEKLMGNAFQLYYTSRSFKGKYDRYKR 1677
            +   ++++   + +     P  Y+ T+  IG V+ KLMG A++  YT R F+
Sbjct: 450  E-GPSNTLGYILRDVRPNIPRGYMYTLHDIGLVINKLMGGAYRSQYTRRRFRSGSK---- 504

Query: 1678 INQSSYFHRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPFNDLLIWAVLTSRHGMAECM 1857
                          Q  L      + +  N +    F YPFN+LLIWAVLT R  MA  M
Sbjct: 505  --------------QDSLTMSLLAETLPANRDTPL-FDYPFNELLIWAVLTKRQQMALLM 549

Query: 1858 WVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRL------FDNAVKCREDAIELLD 2019
            W HGE+A+AK L+A++LYKA A  A ++ L+ E    L      F+N +     A+ELLD
Sbjct: 550  WQHGEEALAKALVALKLYKAMAHEAAEDDLETEVYDELRSYGKEFEN-IGTNICALELLD 608

Query: 2020 QCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRS 2199
             CYR D D+T +LL  EL +W    CLSLAV AN +  LAHPC QI+LA+LW G L+ R
Sbjct: 609  FCYRQDDDQTKQLLTSELQNWSGQTCLSLAVTANHRPLLAHPCSQIILADLWMGGLRTRK 668

Query: 2200 GSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESITSTTSNRYRYSKG 2379
             +N++V+  LICP  I+ + +K   S+    L  +T E+     E     + + +    G
Sbjct: 669  NTNLKVVLGLICPFYIICLEFK---SREELQLMPQTQEEHLIALEDEKEDSDSEHGIPTG 725

Query: 2380 PEEQKE---------------------------TLLEKGSYTKKVTIISSRKNXXXXXXX 2478
            P+ +K                            T++++    +   +++   +
Sbjct: 726  PDVEKRQRRSLSVRNKSSSQQGAKALISNEHTTTIVKETIVQENGKVLTDNDDGIHRAYG 785

Query: 2479 XXXXXXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKY 2658
                    K    L   ++   FY++PITKFW+  IA++IFL   +  +L+     PS
Sbjct: 786  IHSDYYDIKNSRPLRLRKKLYEFYTAPITKFWANAIAYMIFLVLFSYSILIHMDDHPSLA 845

Query: 2659 EWITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVP 2838
            E     Y  TL  E +R++ TSE + ++ K  V+    +N   +AA++FF +G   RL
Sbjct: 846  EIYAIAYICTLGCEKVREIATSEPATLSHKFSVWAWNMWNPCDAAAIIFFQIGLALRL-- 903

Query: 2839 MYRHSW---GRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPL 3009
              RHS    GRV+     + +Y++I   L V+   GP + M  KMV +M Y  VLL+V L
Sbjct: 904  --RHSTLDVGRVIYCVDCIYWYLRILNILGVNKYFGPLVTMMGKMVKNMTYFVVLLIVVL 961

Query: 3010 MAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEID-TCGDEG--IRCFPGY 3180
            ++FGV RQA+  PN +   + ++R+IF +PYFMLYGEVYA  ID  CGDE   I C PG
Sbjct: 962  LSFGVTRQAILNPNAEP-KFRIIRDIFMEPYFMLYGEVYADNIDPDCGDEPGMIPCLPGR 1020

Query: 3181 FIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPP 3360
            +I P +M                      +N+    + ++W+FQR+  +MEY   P LPP
Sbjct: 1021 WITPAVMSIYLLIANILLINLLIAVFNNIFNEVNAVAHQVWMFQRFTVVMEYEQKPVLPP 1080

Query: 3361 PFSIFAHVYHFIDYL--YNLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRI 3534
            P  +  H+Y  + YL  Y  +   +     ++ +KL +  D+M+R+ DFEEDC++   R
Sbjct: 1081 PLIVVCHIYLVVKYLLRYITQGKASSGETYDNGLKLFLEADDMERLYDFEEDCVEGYFRE 1140

Query: 3535 RKLKLNTKEPLSVTDLTELTCQRVHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQ--I 3708
            ++LKL     +S  +  ++T +RV +       + S++ DI+ K ++  N+S + V+  I
Sbjct: 1141 QELKLQ----MSTEERVKITTERVEN-------MHSKIEDIDKK-ENTQNASLQAVEFRI 1188

Query: 3709 LKNKKLS-QNFAASSLSLPDTSIEVPKITKTLIDCHLSPVSIEDRLATRSPLLANLQRDH 3885
             K ++L+ Q  A   +     +  +P I        LS   IE R    S      +R
Sbjct: 1189 RKLEELNEQTLAHLGVIHRFMATHMPNIE------GLSNFDIEGRQRRVS------ERSE 1236

Query: 3886 TLRKYDDANFQPGKLQRRARLHSSSC---------SISQD-MKEMKTSMSSRNLKREDS 4032
             L + D     P    +R RL  S           S+  D MK  +T MS  NL R +S
Sbjct: 1237 VLSETDSHTQLPTITAKRKRLVRSMTDATFLNLGPSLDDDIMKHSETIMSRENLSRNES 1295


>gi|31199943|ref|XP_308919.1| ENSANGP00000005757 [Anopheles gambiae]
 gi|30178864|gb|EAA04234.2| ENSANGP00000005757 [Anopheles gambiae str.
            PEST]
          Length = 1070

 Score =  730 bits (1884), Expect = 0.0
 Identities = 423/1089 (38%), Positives = 617/1089 (55%), Gaps = 21/1089 (1%)
 Frame = +1

Query: 199  RCGCGRPLSAHTPASTFFSTLPVHLLEKEQQTWTIANNTQTSTTDAFGTIVFQGGAHAHK 378
            RC CG+    H   + + + +P         +W  + NT+   TDA+GTI FQGGAH  K
Sbjct: 1    RCCCGQERRTHQVLAGYEAGVPT-------DSWQASKNTRAQPTDAYGTIEFQGGAHPTK 53

Query: 379  AQYVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQ 558
            AQYVRLSYD+ P  ++ L  + W LE P+L+ITV GG +NFEL+ +L ++ RKG+LKAA+
Sbjct: 54   AQYVRLSYDTRPELLVQLFTREWNLELPKLLITVQGGKANFELQPKLKKVLRKGLLKAAK 113

Query: 559  TTGAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHV 738
            TTGAWI T G ++GV + V  AL   G   +   ++V+IGIAPWG+++R   L+  N  V
Sbjct: 114  TTGAWIFTGGTNTGVTKQVGDALLLEG--QQRSGRVVSIGIAPWGIVERNHELLGHNRDV 171

Query: 739  YYDVHSLSV-NANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCNG---R 906
                HS+S   + + +LN+RH+YFLL DNGT GR+GA+L LR+ LE +I+
Sbjct: 172  --PCHSISSPRSKLAVLNNRHAYFLLVDNGTQGRYGAELILRRKLEKYISNQKLQPFTHS 229

Query: 907  KVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDG--TFA 1080
              PVVC ++EGG ++I A+ +YVT  P +P +VCDGSGRAAD+I+F  +Y   +G  T
Sbjct: 230  STPVVCLVIEGGTNTIRAVLEYVTDNPPVPVVVCDGSGRAADLIAFVHKYATDNGEQTVL 289

Query: 1081 AEVGEKLRNLIKMVFP-ETDQ-EEMFRKITECVIRDDLLRIFRYGQEEE---EDVDFVIL 1245
              + + +  +I+  F   T+Q E++F+++ +C    +L+ +FR     E   +++D  IL
Sbjct: 290  ESMHDYVLGIIQKTFEVSTEQAEQLFQELLQCTKNKNLITVFRIQDRPEGNTQELDQTIL 349

Query: 1246 STVLQKQNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVE 1425
            + + + Q+L P EQL+L L+WNRVD+A+S +F  G++W    L++AM  AL  DR+DFV+
Sbjct: 350  TALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPHGALDEAMMQALEHDRIDFVK 409

Query: 1426 CLLENGVSMKNFLSINRLENLYNMDDINSAHSVRNWMENFDSMDPHTYL-TIPMIGQVVE 1602
             LLENGVSM+ FL+I RLE LYN      A+++   + +     P  Y+ T+  IG V+
Sbjct: 410  LLLENGVSMRKFLTIPRLEELYNTKH-GPANTLGYILRDVRPHIPKGYVYTLHDIGLVIN 468

Query: 1603 KLMGNAFQLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKE--LFKKKSDDQINDNEEE 1776
            KLMG A++ YYT R F+  Y   K +N     HRK    Q+   +        +     +
Sbjct: 469  KLMGGAYRSYYTRRKFRPIYA--KVMNSYVNTHRKPSTFQRSAGINSMSLVTGLLPVTTD 526

Query: 1777 DFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVE 1956
               F  PFN+LLIWAVLT R  MA  MW HGE+A+AK L+A +LYKA A  A D+ LD E
Sbjct: 527  MALFELPFNELLIWAVLTKRQQMALLMWTHGEEALAKSLVACKLYKAMAHEAADDDLDTE 586

Query: 1957 EAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFL 2136
              + L   A +     ++LLD CYR D +R  RLL  EL  W + +CLSLAV AN +  L
Sbjct: 587  IYEELRSYAKEFESKGLKLLDFCYRQDAERAQRLLTCELQSWSSQSCLSLAVAANHRAIL 646

Query: 2137 AHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQ 2316
            AHPC QI+LA+LW G L+ R  +N++V+  L+CPP +  + +K          S+E  +Q
Sbjct: 647  AHPCSQIILADLWMGGLRTRKNTNLKVICGLLCPPFVRKLDFK----------SKEELQQ 696

Query: 2317 LPYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXX 2496
            +P   E         Y      +   E LL      K   +  + K
Sbjct: 697  MPQTEEEHLENQYLDYEDRDKKDTDAEALLSDTYSMKDTKVQENGKVSLTDSENTQYKDY 756

Query: 2497 XF----KREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEW 2664
             F    +++  L   ++F  FY++PITKFW+  +A++ FL   T  +L+     PS  EW
Sbjct: 757  LFDSDGRQQRPLKLKKKFYEFYTAPITKFWADSMAYVFFLVLFTYTVLVRMEESPSWQEW 816

Query: 2665 ITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMY 2844
                Y  TL  E IR++++SE   I  K  V+    +N   +AA++FFL+G G RL P Y
Sbjct: 817  YAISYIATLGCEKIREIVSSEPVAIPHKFSVWAWNMWNPCDAAAIIFFLIGLGLRLRP-Y 875

Query: 2845 RHSWGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGV 3024
                GRV+    ++ +Y++I   L V+  LGP + M  KMV +M Y  VLLLV LM+FGV
Sbjct: 876  TMDIGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLLVVLMSFGV 935

Query: 3025 NRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEID-TCGDEGIR--CFPGYFIPPL 3195
            +RQA+  PN  D  W LVR+++Y+PYFMLYGEV+A +ID  CG++  +  C  G+++ P+
Sbjct: 936  SRQAILFPN-NDASWRLVRDVYYQPYFMLYGEVFADDIDPPCGEDPSQPPCVTGHWVTPI 994

Query: 3196 LMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIF 3375
             M                      + +    S ++W+FQR+  +MEY   P LPPP
Sbjct: 995  AMSMYLLIANILLINLLIAVFNNIFIEVNAVSHQVWMFQRFTVVMEYQQKPVLPPPLIAL 1054

Query: 3376 AHVYHFIDY 3402
             H Y  + Y
Sbjct: 1055 CHFYSLLRY 1063


>gi|47214189|emb|CAG00817.1| unnamed protein product [Tetraodon
            nigroviridis]
          Length = 1342

 Score =  721 bits (1861), Expect = 0.0
 Identities = 438/1252 (34%), Positives = 672/1252 (52%), Gaps = 119/1252 (9%)
 Frame = +1

Query: 133  WIENTFEKRECIRFAALPKDPERCGCGRPLSAHTPASTFFSTLPVHLLEKEQQT---WTI 303
            WIE TF+KRECI+  +  KD  RCGCG+ +  H P  T        L++    T   W++
Sbjct: 6    WIEKTFQKRECIQVLS-SKDSSRCGCGQLIVQHHPLQTGNKDEESPLVDVTVPTTERWSV 64

Query: 304  ANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVH 483
              +TQ S TDA+G I FQGG   +KA Y+R+SYDS+P  +++LM K W LE P L+I+VH
Sbjct: 65   LKHTQASPTDAYGLIEFQGGGQVNKATYIRVSYDSKPDSLLHLMVKEWQLELPTLLISVH 124

Query: 484  GGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVAKALDEAGISARMRSQ 663
            GG+ NFEL  +L ++F KG++KAA TTGAWI T G+D+GV+RHV  AL +   S++ R +
Sbjct: 125  GGLQNFELPPKLKQVFGKGLIKAALTTGAWIFTGGVDTGVIRHVGDALKDH--SSKSRGK 182

Query: 664  IVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTVGRFG 843
            +  IG+APWG+++ KE L+ ++    Y + S +  + +  LN  HS+F+LADNGT G++G
Sbjct: 183  VCAIGMAPWGIVENKEDLVGRDVTRPYQMMS-NPFSKLSALNSSHSHFILADNGTTGKYG 241

Query: 844  ADLHLRQNLENHIATFGCNGRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGR 1023
            A++ LR+ LE HIA    N R VPVVC +LEGG + I+ + + +  +P +P ++CDGSGR
Sbjct: 242  AEVRLRRQLEKHIALQKINTR-VPVVCLILEGGPNVISIMLESLREEPPVPVVICDGSGR 300

Query: 1024 AADIISFAARYINSDGTFAAEVGEKLRNLIKMVF--PETDQEEMFRKITECVIRDDLLRI 1197
            AADIISFA +Y   DG  +  + ++L   I+  F    +  + +   +TEC+ +  L+ +
Sbjct: 301  AADIISFAHKYCEEDGMLSDNIKDQLLVTIQKTFNYSRSQAQHILLMVTECMKKKPLITV 360

Query: 1198 FRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCLF------------ 1341
            FR G E ++D++  IL+ +L+  N    +QL+L L+WNRVD+A+S +F
Sbjct: 361  FRMGLEGQQDIEMSILTALLKGTNASASDQLSLALAWNRVDIARSQIFVFGLHAPPVRTL 420

Query: 1342 --------------------------SNGRKWSSDV-----------------LEKAMND 1392
                                      S G K  ++                  LE+AM D
Sbjct: 421  LTDRPKSPKVQQAAAGGGKGKTRGKKSKGGKSKAEAPEETDPRKLELLSWVNSLEQAMMD 480

Query: 1393 ALYWDRVDFVECLLENGVSMKNFLSINRLENLYN--MDDINSAHSVRN-------WMENF 1545
            AL  DRVDFV+ L+ENGV+M +FL+I RLE LYN  +  +N+ H V         W   F
Sbjct: 481  ALVLDRVDFVKLLIENGVNMNHFLTIPRLEELYNTKLGPVNTLHFVVRDVKKVCCWFMLF 540

Query: 1546 ----------------DSMDPHTYLTIPMIGQVVEKLMGNAFQLYYTSRSFKGKYDRYKR 1677
                             ++ P   +T+  IG V+E LMG A++  YT +SF+  Y+
Sbjct: 541  RCFRLHMRLRRSCVFQGNLPPDYQITLIDIGLVLEVLMGGAYRCKYTRKSFRTLYNNLYG 600

Query: 1678 INQSSYF--------HRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPFNDLLIWAVLTS 1833
            + +              + K   K+  KK+ +  I+ ++ E   F YPF++L++WAVLT
Sbjct: 601  LKRPKALKLLGMEDDEPRSKGKGKKNKKKEEEVDIDVDDPEVSRFQYPFHELMVWAVLTK 660

Query: 1834 RHGMAECMWVHGEDAMAKCLLAIRLYKATA------KIAEDEYLDVEEAKRLFDNAVKCR 1995
            R  MA  +W HGE+AMAK L+A +LYKA A      ++ +D + D+E   R F
Sbjct: 661  RQKMALFLWQHGEEAMAKALVACKLYKAMAHESSQSELVDDIFQDLESNSREFGQL---- 716

Query: 1996 EDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQILLAELW 2175
              A ELLDQ Y+ D    ++LL  EL +W N+ CL LAV A  + F+AH C Q+LL ++W
Sbjct: 717  --AYELLDQSYKRDEQVAMKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMW 774

Query: 2176 HGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESITSTTS 2355
             G L++   ++++V+  +I PPAIL + ++         L EE       P E+  S T
Sbjct: 775  MGCLRMGKSNSLKVILGIIFPPAILLLDFR---------LGEEASN----PSENQESGTK 821

Query: 2356 NR-YRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXXFKREPQLNK-F 2529
            +   + SK      +   +KG   ++      +K+               +R P + K F
Sbjct: 822  DEDNKSSKDVASNVDVTSKKGDEEEE-----QKKSK--------------RRTPVVKKIF 862

Query: 2530 ERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVEHIR 2709
            E    FY++P TKFW   I++L++L     I+L++    PS  EW    Y +TL +E +R
Sbjct: 863  E----FYNAPFTKFWFNTISYLVYLMLYNYIILVKMERWPSLQEWTVIAYIITLGLEKVR 918

Query: 2710 KLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFSNVL 2889
            +++ SE  ++ +K+ V+   ++NI    A+  FL+G   RL       +GRV+     +
Sbjct: 919  QILMSEPGKLKQKINVWLEDYWNITDLVAISVFLLGLLLRLQNEPSMGYGRVIYCVDIIF 978

Query: 2890 FYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKDWHW 3069
            +Y+++ +   V+  LGPY+ M  KM+  M Y  V++LV LM+FGV RQA+  P+ ++  W
Sbjct: 979  WYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQAILHPD-EEPTW 1037

Query: 3070 LLVRNIFYKPYFMLYGEVYAGEID--------TCGD-----EGIR---CFPGYFIPPLLM 3201
             L RNIFY PY+M+YGEV+A  ID         CGD     +G +   C PG ++ P +M
Sbjct: 1038 RLARNIFYMPYWMIYGEVFADSIDLYAMEINPPCGDNMYDEDGKKLPPCIPGAWLTPAIM 1097

Query: 3202 XXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAH 3381
                                  + +    S ++W FQRYQ +M +HD P LPPP  IF+H
Sbjct: 1098 ACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPILPPPLIIFSH 1157

Query: 3382 VYHFIDYLY--NLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTR 3531
            ++  +  L      RPD +R   E  ++L +  +E+K + +FEE C++   R
Sbjct: 1158 IFILLRRLLCPCRHRPDGERDHRERGLQLVLNPEELKSLHEFEEQCVEEYFR 1209


>gi|19922314|ref|NP_611026.1| CG30078-PA [Drosophila melanogaster]
 gi|17861698|gb|AAL39326.1| GH22805p [Drosophila melanogaster]
 gi|21627148|gb|AAF58153.2| CG30078-PA [Drosophila melanogaster]
          Length = 1131

 Score =  715 bits (1845), Expect = 0.0
 Identities = 422/1122 (37%), Positives = 624/1122 (55%), Gaps = 32/1122 (2%)
 Frame = +1

Query: 133  WIENTFEKRECIRFAALPKDPERCGCGRPLSAHTPASTFFSTLPVHLLEKEQQTWTIANN 312
            WIE  F+KRECI+F   PKD  +C CG+    H       S  P  L       W    +
Sbjct: 15   WIETNFQKRECIKFIPCPKDDTKCCCGQAQITHQTIPGIESGSPGDL-------WLPTKH 67

Query: 313  TQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGM 492
            T+   TDA+GTI FQGGAH  KAQYVRLS+D+ P  ++ L  K W LE P+L+ITV GG
Sbjct: 68   TRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGK 127

Query: 493  SNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVT 672
            +NF+L+ +L +  RKG+LKAA+TTGAWI T G ++GV + V  AL   G   +   ++V+
Sbjct: 128  ANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEG--QQRTGRVVS 185

Query: 673  IGIAPWGVIKRKERLIRQNEHVYYDVHSLSV-NANVGILNDRHSYFLLADNGTVGRFGAD 849
            IGIAPWG+++R   L+  N  V    HS+S   + + +LN+RH+YFLL DNGT  ++GA+
Sbjct: 186  IGIAPWGIVERNHELLGHNREV--PCHSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAE 243

Query: 850  LHLRQNLENHIATFGCNG---RKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSG 1020
            L LR+ LE  I+    +       PVVC ++EGG ++I A+ +YVT  P +P +VCDGSG
Sbjct: 244  LILRRKLEKFISNLKLHPFTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSG 303

Query: 1021 RAADIISFAARYINSDGTFAAEVGEKLRNLIKMVFPET------DQEEMFRKITECVIRD 1182
            RAAD+++F  +Y  SDG     V E +R+ +     +T        E++++++ +C
Sbjct: 304  RAADLLAFVHKYA-SDGE-EQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNK 361

Query: 1183 DLLRIFRYGQEEE---EDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCLFSNGR 1353
            +L+ +FR  ++ E   +++D  IL+ + + Q+L P EQL+L L+WNRVD+A+S +F  G+
Sbjct: 362  NLITVFRIQEKPEGEAQELDQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQ 421

Query: 1354 KWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDDINSAHSVRNW 1533
            +W +  L++AM  AL  DR+DFV+ LLENGVSMK FL+I RLE LYN      A+++
Sbjct: 422  EWPNGALDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKH-GPANTLGYI 480

Query: 1534 MENFDSMDPHTYL-TIPMIGQVVEKLMGNAFQLYYTSRSFKGKYDRYKRINQSSYFHRKR 1710
            + +     P  Y+ T+  IG V+ KLMG A++ YYT R F+  Y   K +N  +   RK
Sbjct: 481  LRDVRPHIPKGYIYTLHDIGLVINKLMGGAYRSYYTRRKFRPIYA--KVMNSYANACRKS 538

Query: 1711 KIVQKELFKKKSDDQINDN----EEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDA 1878
               Q + +   +   +         E   F +PFN+LLIWAVLT R  MA  MW HGE+A
Sbjct: 539  STYQYQRYAGANSLSLVTGLLPFTSEMALFEFPFNELLIWAVLTKRQQMALLMWTHGEEA 598

Query: 1879 MAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRL 2058
            +AK L++ +LYKA A  A ++ LD E  + L   A +      +LLD  YR D ++  RL
Sbjct: 599  LAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRL 658

Query: 2059 LRMELPHWGNNNCLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICP 2238
            L  EL  W N +CLSLAV AN +  LAHPC Q++LA+LW G L+ R  +N +V+  L  P
Sbjct: 659  LTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMP 718

Query: 2239 PAILFMAYKPKHSKTARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEKGS 2418
              I  + +K          S+E  +Q+P   E      +     S   +   E LL   +
Sbjct: 719  FYIRQLDFK----------SKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAEALL-ADT 767

Query: 2419 YTKKVTIISSRKNXXXXXXXXXXXXXXF--------KREPQLNKFERFRAFYSSPITKFW 2574
            Y+ + T +                   F        K+   L   ++F  FY++PITKFW
Sbjct: 768  YSVRDTKVHENGKVSLTDSDTAQFREFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFW 827

Query: 2575 SWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVK 2754
            +  IA++ FL   +  +L++    P   EW +  Y  TL  E +R++++SE   I  K
Sbjct: 828  ADSIAYMFFLIMFSFTVLVKMEQMPRWQEWYSIAYITTLGFEKVREIISSEPVAITHKFS 887

Query: 2755 VFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSW---GRVLLSFSNVLFYMKIFEYLSVH 2925
            V+    +N    AA++ F++G  FR    +R +    GRV+    ++ +Y++I   L V+
Sbjct: 888  VWAWNMWNPCDGAAIILFVIGLAFR----FRENTMDIGRVIYCVDSIYWYLRILNILGVN 943

Query: 2926 PLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYF 3105
              LGP + M  KMV +M Y  VLL V LM+FGV+RQA+  PN K   W L++ + ++PYF
Sbjct: 944  KYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPN-KQPTWSLIKEVTFQPYF 1002

Query: 3106 MLYGEVYAGEID-TCGDEGIR--CFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYND 3276
            MLYGEV+AG+ID  CG++  +  C  G+++ P+ M                      +N+
Sbjct: 1003 MLYGEVFAGDIDPPCGEDPSQPGCVTGHWVTPITMSMYLLIANILLINLLIAVFNNIFNE 1062

Query: 3277 SIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDY 3402
                S ++W+FQR+  +MEY   P LPPPF    H Y  + Y
Sbjct: 1063 VNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLLKY 1104


>gi|29893552|ref|NP_060142.2| transient receptor potential cation
            channel, subfamily M, member 7; LTRPC ion channel family
            member 7 [Homo sapiens]
 gi|13562153|gb|AAK19738.2| channel-kinase 1 [Homo sapiens]
          Length = 1864

 Score =  702 bits (1813), Expect = 0.0
 Identities = 450/1410 (31%), Positives = 737/1410 (51%), Gaps = 91/1410 (6%)
 Frame = +1

Query: 133  WIENTFEKRECIRFAALPKDPERC-------------GCGRPLSAHT--PASTFFSTLPV 267
            WIE+T  KREC+      KDP RC              CGR +  H    AS       V
Sbjct: 6    WIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMKYSDV 65

Query: 268  HLLEKEQQT---WTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLME 438
             L +   Q    W++  +T+ S TDA+G I FQGG+H+++A+YVRLSYD++P  ++ L+
Sbjct: 66   KLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVILQLLL 125

Query: 439  KVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVA 618
            K W +E P+LVI+VHGGM  FEL  R+ +L  KG++KAA TTGAWI+T G+++GV +HV
Sbjct: 126  KEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVAKHVG 185

Query: 619  KALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRH 798
             AL E   ++R   +I TIGIAPWGVI+ +  L+ ++    Y    L+  + + +LN+ H
Sbjct: 186  DALKEH--ASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQT-LLNPLSKLNVLNNLH 242

Query: 799  SYFLLADNGTVGRFGADLHLRQNLENHIATFGCN---GRKVPVVCTLLEGGISSINAIHD 969
            S+F+L D+GTVG++GA++ LR+ LE  I     +   G+ VPVV  + EGG + I  + +
Sbjct: 243  SHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTVLE 302

Query: 970  YVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMVFPETDQE-- 1143
            Y+   P +P +VC+G+GRAAD++++  +     G         + + IK  F     E
Sbjct: 303  YLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQNEAL 362

Query: 1144 EMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDL 1323
             +F+ + EC+ R +L+ +F  G +E +D+D  IL+ +L+  N    +QL LTL+W+RVD+
Sbjct: 363  HLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASAFDQLILTLAWDRVDI 422

Query: 1324 AKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDD 1503
            AK+ +F  G++W    LE+AM DAL  DRV FV+ L+ENGVSM  FL+I RLE LYN
Sbjct: 423  AKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNTKQ 482

Query: 1504 INSA----HSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNAFQLYYTSRSFK------ 1653
              +     H VR+  +   ++ P   +T+  IG V+E LMG  ++  YT + F+
Sbjct: 483  GPTNPMLFHLVRDVKQG--NLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSL 540

Query: 1654 GKYDRYKRINQSSYFHRKRK--------------------------------IVQKELFK 1737
            G  +R    N SS   + RK                                 V +E  K
Sbjct: 541  GGNNRRSGRNTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKK 600

Query: 1738 KKSDDQIND-NEEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYK 1914
            K++ D+I D ++ E   F YP N+LLIWA L  R  MA  +W HGE++MAK L+A ++Y+
Sbjct: 601  KRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYR 660

Query: 1915 ATAKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNN 2094
            + A  A+   L  + ++ L   +    + A+ELL+Q +R D    ++LL  EL +W N+
Sbjct: 661  SMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNST 720

Query: 2095 CLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKH 2274
            CL LAV +  + F+AH C Q+LL+++W G L +R  S  +V+ +++ PPAIL + YK K
Sbjct: 721  CLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKA 780

Query: 2275 SKTARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEK--GSYTKKVTIISS 2448
              +           +P  +++   T  +        E   + + E+      K+V I+ S
Sbjct: 781  EMS----------HIPQSQDAHQMTMDD-------SENNFQNITEEIPMEVFKEVRILDS 823

Query: 2449 RKNXXXXXXXXXXXXXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILL 2628
             +                 +  +L    +F AFY +PI KFW   +A+L FL   T ++L
Sbjct: 824  NEGKNEMEIQ--------MKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVL 875

Query: 2629 LETSLKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFF 2808
            ++    PS  EWI   Y  T ++E +R++  SE  ++N+K+KV+++ ++NI  + A++ F
Sbjct: 876  VQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISF 935

Query: 2809 LVGYGFRLVPMYRHS---------WGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAK 2961
             +G+G R    +  +          GR++   + + +Y+++ ++L+V+   GPY+ M  K
Sbjct: 936  FIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGK 995

Query: 2962 MVWSMCYICVLLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEID 3141
            MV +M YI V++ + L++FGV R+A+  P+     W L ++I + PY+M++GEVYA EID
Sbjct: 996  MVANMFYIVVIMALVLLSFGVPRKAILYPHEAP-SWTLAKDIVFHPYWMIFGEVYAYEID 1054

Query: 3142 TCGDEGI---RCFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQ 3312
             C ++ +    C PG ++ P L                       Y      S  +W +Q
Sbjct: 1055 VCANDSVIPQICGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQ 1114

Query: 3313 RYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRRPDTKRFRSEHSIKLSVTEDEMKRI 3492
            RY  +M YH+ P LPPP  I +H+      +   R+ D    ++    KL +TE++ K++
Sbjct: 1115 RYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKRRKKD----KTSDGPKLFLTEEDQKKL 1170

Query: 3493 QDFEEDCIDTLTRIR--KLKLNTKEPLSVT-DLTELTCQRVHDLMQENFLLKSRVYDIET 3663
             DFEE C++     +  K    ++E + VT +  E  C ++ ++      +K  +  +++
Sbjct: 1171 HDFEEQCVEMYFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDS 1230

Query: 3664 KIDHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEVPKITKTL-IDCHLSPVSIEDR 3840
            +I H+ + S   V  LK     +   AS +          +IT+ L I  HL+   I+D
Sbjct: 1231 QIGHLQDLSALTVDTLKTLTAQKASEASKVH--------NEITRELSISKHLAQNLIDD- 1281

Query: 3841 LATRSPLLANLQRDHTLRKYDDANFQPGKLQRRARLHSSSCSI-SQDMKEMKTSMSSRNL 4017
                 P+  ++ + H +     ++   G L+     H   C+I  +D K+ + ++  ++L
Sbjct: 1282 ----GPVRPSVWKKHGVVNTLSSSLPQGDLESNNPFH---CNILMKDDKDPQCNIFGQDL 1334

Query: 4018 ------KREDSGEITTSSHGGYDSDVSGPD 4089
                  K  +  E  +SS   + S VS P+
Sbjct: 1335 PAVPQRKEFNFPEAGSSSGALFPSAVSPPE 1364


>gi|13959785|gb|AAK44211.1| LTRPC7 [Homo sapiens]
          Length = 1865

 Score =  702 bits (1813), Expect = 0.0
 Identities = 450/1410 (31%), Positives = 737/1410 (51%), Gaps = 91/1410 (6%)
 Frame = +1

Query: 133  WIENTFEKRECIRFAALPKDPERC-------------GCGRPLSAHT--PASTFFSTLPV 267
            WIE+T  KREC+      KDP RC              CGR +  H    AS       V
Sbjct: 6    WIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMKYSDV 65

Query: 268  HLLEKEQQT---WTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLME 438
             L +   Q    W++  +T+ S TDA+G I FQGG+H+++A+YVRLSYD++P  ++ L+
Sbjct: 66   KLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVILQLLL 125

Query: 439  KVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVA 618
            K W +E P+LVI+VHGGM  FEL  R+ +L  KG++KAA TTGAWI+T G+++GV +HV
Sbjct: 126  KEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVAKHVG 185

Query: 619  KALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRH 798
             AL E   ++R   +I TIGIAPWGVI+ +  L+ ++    Y    L+  + + +LN+ H
Sbjct: 186  DALKEH--ASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQT-LLNPLSKLNVLNNLH 242

Query: 799  SYFLLADNGTVGRFGADLHLRQNLENHIATFGCN---GRKVPVVCTLLEGGISSINAIHD 969
            S+F+L D+GTVG++GA++ LR+ LE  I     +   G+ VPVV  + EGG + I  + +
Sbjct: 243  SHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTVLE 302

Query: 970  YVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMVFPETDQE-- 1143
            Y+   P +P +VC+G+GRAAD++++  +     G         + + IK  F     E
Sbjct: 303  YLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQNEAL 362

Query: 1144 EMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDL 1323
             +F+ + EC+ R +L+ +F  G +E +D+D  IL+ +L+  N    +QL LTL+W+RVD+
Sbjct: 363  HLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASAFDQLILTLAWDRVDI 422

Query: 1324 AKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDD 1503
            AK+ +F  G++W    LE+AM DAL  DRV FV+ L+ENGVSM  FL+I RLE LYN
Sbjct: 423  AKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNTKQ 482

Query: 1504 INSA----HSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNAFQLYYTSRSFK------ 1653
              +     H VR+  +   ++ P   +T+  IG V+E LMG  ++  YT + F+
Sbjct: 483  GPTNPMLFHLVRDVKQG--NLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSL 540

Query: 1654 GKYDRYKRINQSSYFHRKRK--------------------------------IVQKELFK 1737
            G  +R    N SS   + RK                                 V +E  K
Sbjct: 541  GGNNRRSGRNTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKK 600

Query: 1738 KKSDDQIND-NEEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYK 1914
            K++ D+I D ++ E   F YP N+LLIWA L  R  MA  +W HGE++MAK L+A ++Y+
Sbjct: 601  KRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYR 660

Query: 1915 ATAKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNN 2094
            + A  A+   L  + ++ L   +    + A+ELL+Q +R D    ++LL  EL +W N+
Sbjct: 661  SMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNST 720

Query: 2095 CLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKH 2274
            CL LAV +  + F+AH C Q+LL+++W G L +R  S  +V+ +++ PPAIL + YK K
Sbjct: 721  CLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKA 780

Query: 2275 SKTARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEK--GSYTKKVTIISS 2448
              +           +P  +++   T  +        E   + + E+      K+V I+ S
Sbjct: 781  EMS----------HIPQSQDAHQMTMDD-------SENNFQNITEEIPMEVFKEVRILDS 823

Query: 2449 RKNXXXXXXXXXXXXXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILL 2628
             +                 +  +L    +F AFY +PI KFW   +A+L FL   T ++L
Sbjct: 824  NEGKNEMEIQ--------MKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVL 875

Query: 2629 LETSLKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFF 2808
            ++    PS  EWI   Y  T ++E +R++  SE  ++N+K+KV+++ ++NI  + A++ F
Sbjct: 876  VQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISF 935

Query: 2809 LVGYGFRLVPMYRHS---------WGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAK 2961
             +G+G R    +  +          GR++   + + +Y+++ ++L+V+   GPY+ M  K
Sbjct: 936  FIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGK 995

Query: 2962 MVWSMCYICVLLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEID 3141
            MV +M YI V++ + L++FGV R+A+  P+     W L ++I + PY+M++GEVYA EID
Sbjct: 996  MVANMFYIVVIMALVLLSFGVPRKAILYPHEAP-SWTLAKDIVFHPYWMIFGEVYAYEID 1054

Query: 3142 TCGDEGI---RCFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQ 3312
             C ++ +    C PG ++ P L                       Y      S  +W +Q
Sbjct: 1055 VCANDSVIPQICGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQ 1114

Query: 3313 RYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRRPDTKRFRSEHSIKLSVTEDEMKRI 3492
            RY  +M YH+ P LPPP  I +H+      +   R+ D    ++    KL +TE++ K++
Sbjct: 1115 RYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKRRKKD----KTSDGPKLFLTEEDQKKL 1170

Query: 3493 QDFEEDCIDTLTRIR--KLKLNTKEPLSVT-DLTELTCQRVHDLMQENFLLKSRVYDIET 3663
             DFEE C++     +  K    ++E + VT +  E  C ++ ++      +K  +  +++
Sbjct: 1171 HDFEEQCVEMYFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDS 1230

Query: 3664 KIDHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEVPKITKTL-IDCHLSPVSIEDR 3840
            +I H+ + S   V  LK     +   AS +          +IT+ L I  HL+   I+D
Sbjct: 1231 QIGHLQDLSALTVDTLKTLTAQKASEASKVH--------NEITRELSISKHLAQNLIDD- 1281

Query: 3841 LATRSPLLANLQRDHTLRKYDDANFQPGKLQRRARLHSSSCSI-SQDMKEMKTSMSSRNL 4017
                 P+  ++ + H +     ++   G L+     H   C+I  +D K+ + ++  ++L
Sbjct: 1282 ----GPVRPSVWKKHGVVNTLSSSLPQGDLESNNPFH---CNILMKDDKDPQCNIFGQDL 1334

Query: 4018 ------KREDSGEITTSSHGGYDSDVSGPD 4089
                  K  +  E  +SS   + S VS P+
Sbjct: 1335 PAVPQRKEFNFPEAGSSSGALFPSAVSPPE 1364


>gi|50753109|ref|XP_425074.1| PREDICTED: similar to transient receptor
            potential cation channel, subfamily M, member 7; LTRPC
            ion channel family member 7 [Gallus gallus]
          Length = 2008

 Score =  695 bits (1794), Expect = 0.0
 Identities = 437/1322 (33%), Positives = 705/1322 (53%), Gaps = 87/1322 (6%)
 Frame = +1

Query: 133  WIENTFEKRECIRFAALPKDPERC-------------GCGRPLSAHT--PASTFFSTLPV 267
            WIENTF KREC+      KDP RC              CGR +  H    AS       V
Sbjct: 30   WIENTFTKRECVYIIPSSKDPHRCLPGCQICQQLVRCCCGRLVRQHACFTASLAMKYSDV 89

Query: 268  HLLE---KEQQTWTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLME 438
             L E   +E + W++  +T+ ++TDA+G I FQGG+H+++A+YVRLSYD++P  ++ LM
Sbjct: 90   KLGENCNQEIEEWSVEKHTEQTSTDAYGVINFQGGSHSYRAKYVRLSYDTKPEAILQLML 149

Query: 439  KVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVA 618
            K W +E P+LVI+VHGGM  FEL  R+ +L  KG++KAA TTGAWIIT G+++GV +HV
Sbjct: 150  KEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWIITGGVNTGVAKHVG 209

Query: 619  KALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRH 798
             AL E   ++R   +I TIGIAPWGVI+ +  L+ ++    Y    L+  + + +LN+ H
Sbjct: 210  DALREH--ASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQT-LLNPLSKLNVLNNLH 266

Query: 799  SYFLLADNGTVGRFGADLHLRQNLENHIATFGCN---GRKVPVVCTLLEGGISSINAIHD 969
            S+F+L D+GTVG++GA++ LR+ LE  I     +   G+ VPVV  + EGG + I  + D
Sbjct: 267  SHFILVDDGTVGKYGAEVKLRRELEKTINLQRIHARIGQGVPVVALVFEGGPNVILTVLD 326

Query: 970  YVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMV--FPETDQE 1143
            ++   P +P +VC+G+GRAADI+++  +     G        ++ + IK    F +++
Sbjct: 327  FLHESPPVPVVVCEGTGRAADILAYVHKQTEEGGNVPEGAEPEIISTIKKTFNFGQSEAV 386

Query: 1144 EMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDL 1323
             +F+ + EC+ + +L+ +F  G +E +D+D  IL+ +L+  N    +QL LTL+W+RVD+
Sbjct: 387  HLFQTLLECMKKKELITVFHIGSDEHQDIDVAILTALLKGTNASAFDQLVLTLAWDRVDI 446

Query: 1324 AKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNM-- 1497
            AK+ +F  G++W    LE+AM DAL  DRV FV+ L+ENGVSM  FL+I RLE LYN
Sbjct: 447  AKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNTKQ 506

Query: 1498 --DDINSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNAFQLYYTSRSFKGKY--- 1662
               +    H VR+  +   ++ P   + +  +G V+E LMG  ++  YT + F+  Y
Sbjct: 507  GPTNPTLFHLVRDVKQG--NLPPGYKINLIDVGLVIEYLMGGTYRCTYTRKRFRAIYNSL 564

Query: 1663 -----------------------------DRYKRINQSSYFHRKRKIVQK------ELFK 1737
                                         D+ +++  + +    +    K      E  K
Sbjct: 565  SGNNRRSGRNPSNTTPQLCKSHESFGNRADKKEKMRHNHFIKTAQPYKPKIDTGAEEGKK 624

Query: 1738 KKSDDQIND-NEEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYK 1914
            K++ D+I D ++ E   F YP N+LL+WAVL  R  MA   W HGE++MAK L+A ++Y+
Sbjct: 625  KRTKDEIVDIDDPETRRFPYPLNELLLWAVLMKRQKMALFFWQHGEESMAKALVACKVYR 684

Query: 1915 ATAKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNN 2094
            + A  A+   L  + ++ L   + +  + A+ELL+Q +R D    ++LL  EL +W N+
Sbjct: 685  SMAYEAKQSDLVDDTSEELKQYSNEFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNST 744

Query: 2095 CLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKH 2274
            CL LAV +  + F+AH C Q+LL+++W G L +R  S  +V+ +++ PPAIL + YK K
Sbjct: 745  CLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILLPPAILLLEYKTKA 804

Query: 2275 SKTARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRK 2454
              +    S++  +      E+    T++       P E  + +    S T+K  + +  K
Sbjct: 805  EMSHIPQSQDAHQMAMDDSENNFQNTADEI-----PMEVFKEVRILDSTTEKHDMETPAK 859

Query: 2455 NXXXXXXXXXXXXXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLE 2634
                            KR P   K   F AFY +PI KFW   +A+L FL   T ++L++
Sbjct: 860  P---------------KRLPITQK---FYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVK 901

Query: 2635 TSLKPSKYEWITFIYTVTLSVEHIRKL-MTSEGSRINEKVKVFYAKWYNIWTSAALLFFL 2811
                PS  EWI   Y  T ++E IR++   SE  +IN+K+KV+++ ++NI  + A++ F
Sbjct: 902  MEEVPSVQEWIVIAYIFTSAIEKIREIFFMSEAGKINQKIKVWFSDYFNISDTVAIVTFF 961

Query: 2812 VGYGFRL-------VPMYRHSW----GRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAA 2958
            +G+  R           YR ++    GR+    + + +Y+++ ++L+V+   GPY+ M
Sbjct: 962  IGFVLRFGAKGNFGENTYRENYIFVAGRITYCLNIIFWYVRLLDFLAVNQQAGPYVMMIG 1021

Query: 2959 KMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEI 3138
            KMV +M YI V++ + L++FGV R+A+  PN     W L R+I + PY+M++GEVYA EI
Sbjct: 1022 KMVANMFYIVVIMALVLLSFGVPRKAILYPNEAP-SWTLARDIVFHPYWMIFGEVYAYEI 1080

Query: 3139 DTCGDEGIR-----CFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIW 3303
            D C +         C PG ++ P L                       Y      S  +W
Sbjct: 1081 DVCANNSESQVAHLCGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVW 1140

Query: 3304 LFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRRPDTKRFRSEHSIKLSVTEDEM 3483
             +QRY  +M YH+ P LPPP  I +H+   +  +   R+ D    ++    KL +TE++
Sbjct: 1141 KYQRYHFIMAYHEKPVLPPPLIILSHMASLLCCICKRRKTD----KTSDGPKLFLTEEDQ 1196

Query: 3484 KRIQDFEEDCIDTLTRIR--KLKLNTKEPLSVT-DLTELTCQRVHDLMQENFLLKSRVYD 3654
            K++ DFEE C++     +  K    ++E + VT +  E  C ++ ++      +K  +
Sbjct: 1197 KKLHDFEELCVEMYFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQS 1256

Query: 3655 IETKIDHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEVPKITKTL-IDCHLSPVSI 3831
            ++++I H+ + S   V  LK     +   AS +          +IT+ L I  HL+   I
Sbjct: 1257 LDSQIGHLQDLSALTVDTLKTLTAQKASEASKVH--------NEITRELSISKHLAQNLI 1308

Query: 3832 ED 3837
            +D
Sbjct: 1309 DD 1310


>gi|10946830|ref|NP_067425.1| transient receptor potential cation
            channel, subfamily M, member 7; transient receptor
            potential-related protein, ChaK; transient receptor
            potential M7 [Mus musculus]
 gi|8131903|gb|AAF73131.1| transient receptor potential-related
            protein [Mus musculus]
          Length = 1863

 Score =  691 bits (1784), Expect = 0.0
 Identities = 427/1317 (32%), Positives = 699/1317 (52%), Gaps = 82/1317 (6%)
 Frame = +1

Query: 133  WIENTFEKRECIRFAALPKDPERC-------------GCGRPLSAHT--PASTFFSTLPV 267
            WIE+T  KREC+      KDP RC              CGR +  H    AS       V
Sbjct: 6    WIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMKYSDV 65

Query: 268  HLLEKEQQT---WTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLME 438
             L E   Q    W++  +T+ S TDA+G I FQGG+H+++A+YVRLSYD++P  ++ L+
Sbjct: 66   RLGEHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEIILQLLL 125

Query: 439  KVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVA 618
            K W +E P+LVI+VHGGM  FEL  R+ +L  KG++KAA TTGAWI+T G+++GV +HV
Sbjct: 126  KEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVAKHVG 185

Query: 619  KALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRH 798
             AL E   ++R   +I TIGIAPWGVI+ +  L+ ++    Y    L+  + + +LN+ H
Sbjct: 186  DALKEH--ASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQT-LLNPLSKLNVLNNLH 242

Query: 799  SYFLLADNGTVGRFGADLHLRQNLENHIATFGCN---GRKVPVVCTLLEGGISSINAIHD 969
            S+F+L D+GTVG++GA++ LR+ LE  I     +   G+ VPVV  + EGG + I  + +
Sbjct: 243  SHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTVLE 302

Query: 970  YVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMVFP--ETDQE 1143
            Y+   P +P +VC+G+GRAAD++++  +     G         + + IK  F   +++
Sbjct: 303  YLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQSEAV 362

Query: 1144 EMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDL 1323
             +F+ + EC+ + +L+ +F  G E+ +D+D  IL+ +L+  N    +QL LTL+W+RVD+
Sbjct: 363  HLFQTMMECMKKKELITVFHIGSEDHQDIDVAILTALLKGTNASAFDQLILTLAWDRVDI 422

Query: 1324 AKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDD 1503
            AK+ +F  G++W    LE+AM DAL  DRV FV+ L+ENGVSM  FL+I RLE LYN
Sbjct: 423  AKNHVFVYGQQWLVGSLEQAMLDALVMDRVSFVKLLIENGVSMHKFLTIPRLEELYNTKQ 482

Query: 1504 INSA----HSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNAFQLYYTSRSFKGKY--- 1662
              +     H +R+  +   ++ P   +T+  IG V+E LMG  ++  YT + F+  Y
Sbjct: 483  GPTNPMLFHLIRDVKQG--NLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSL 540

Query: 1663 -----------------------------DRYKRINQSSY------FHRKRKIVQKELFK 1737
                                         D+ +++  + +      +  K     +E  K
Sbjct: 541  GGNNRRSGRNTSSSTPQLRKSHETFGNRADKKEKMRHNHFIKTAQPYRPKMDASMEEGKK 600

Query: 1738 KKSDDQIND-NEEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYK 1914
            K++ D+I D ++ E   F YP N+LLIWA L  R  MA  +W HGE++MAK L+A ++Y+
Sbjct: 601  KRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYR 660

Query: 1915 ATAKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNN 2094
            + A  A+   L  + ++ L   +    + A+ELL+Q +R D    ++LL  EL +W N+
Sbjct: 661  SMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNST 720

Query: 2095 CLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKH 2274
            CL LAV +  + F+AH C Q+LL+++W G L +R  S  +V+ +++ PPAIL + YK K
Sbjct: 721  CLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILMLEYKTKA 780

Query: 2275 SKTARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRK 2454
              +    S++           +T   S    ++   E   E   E      K+   S  K
Sbjct: 781  EMSHIPQSQDA--------HQMTMEDSENNFHNITEEIPMEVFKE-----VKILDSSDGK 827

Query: 2455 NXXXXXXXXXXXXXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLE 2634
            N                +  +L    +F AFY +PI KFW   +A+L FL   T ++L++
Sbjct: 828  NEMEIHI----------KSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVK 877

Query: 2635 TSLKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLV 2814
                PS  EWI   Y  T ++E +R++  SE  +I++K+KV+++ ++N+  + A++ F V
Sbjct: 878  MEQLPSVQEWIVIAYIFTYAIEKVREVFMSEAGKISQKIKVWFSDYFNVSDTIAIISFFV 937

Query: 2815 GYGFRLVPMYRH---------SWGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMV 2967
            G+G R    + +           GR++   + + +Y+++ ++L+V+   GPY+ M  KMV
Sbjct: 938  GFGLRFGAKWNYINAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMV 997

Query: 2968 WSMCYICVLLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEIDTC 3147
             +M YI V++ + L++FGV R+A+  P+ ++  W L ++I + PY+M++GEVYA EID C
Sbjct: 998  ANMFYIVVIMALVLLSFGVPRKAILYPH-EEPSWSLAKDIVFHPYWMIFGEVYAYEIDVC 1056

Query: 3148 GDEGIR---CFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRY 3318
             ++      C PG ++ P L                       Y      S  +W +QRY
Sbjct: 1057 ANDSTLPTICGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRY 1116

Query: 3319 QQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRRPDTKRFRSEHSIKLSVTEDEMKRIQD 3498
              +M YH+ P LPPP  I +H+      +   R+ D    ++    KL +TE++ K++ D
Sbjct: 1117 HFIMAYHEKPVLPPPLIILSHIVSLFCCVCKRRKKD----KTSDGPKLFLTEEDQKKLHD 1172

Query: 3499 FEEDCIDTLTRIRKLKLN--TKEPLSVT-DLTELTCQRVHDLMQENFLLKSRVYDIETKI 3669
            FEE C++     +  K N  ++E + VT +  E    ++ ++      +K  +  ++++I
Sbjct: 1173 FEEQCVEMYFDEKDDKFNSGSEERIRVTFERVEQMSIQIKEVGDRVNYIKRSLQSLDSQI 1232

Query: 3670 DHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEVPKITKTL-IDCHLSPVSIED 3837
             H+ + S   V  LK     +   AS +          +IT+ L I  HL+   I+D
Sbjct: 1233 GHLQDLSALTVDTLKTLTAQKASEASKVH--------NEITRELSISKHLAQNLIDD 1281


>gi|14211383|gb|AAK57433.1| transient receptor potential phospholipase
            C interacting kinase [Mus musculus]
          Length = 1862

 Score =  691 bits (1783), Expect = 0.0
 Identities = 427/1317 (32%), Positives = 699/1317 (52%), Gaps = 82/1317 (6%)
 Frame = +1

Query: 133  WIENTFEKRECIRFAALPKDPERC-------------GCGRPLSAHT--PASTFFSTLPV 267
            WIE+T  KREC+      KDP RC              CGR +  H    AS       V
Sbjct: 6    WIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMKYSDV 65

Query: 268  HLLEKEQQT---WTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLME 438
             L E   Q    W++  +T+ S TDA+G I FQGG+H+++A+YVRLSYD++P  ++ L+
Sbjct: 66   KLGEHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEIILQLLL 125

Query: 439  KVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVA 618
            K W +E P+LVI+VHGGM  FEL  R+ +L  KG++KAA TTGAWI+T G+++GV +HV
Sbjct: 126  KEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVAKHVG 185

Query: 619  KALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRH 798
             AL E   ++R   +I TIGIAPWGVI+ +  L+ ++    Y    L+  + + +LN+ H
Sbjct: 186  DALKEH--ASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQT-LLNPLSKLNVLNNLH 242

Query: 799  SYFLLADNGTVGRFGADLHLRQNLENHIATFGCN---GRKVPVVCTLLEGGISSINAIHD 969
            S+F+L D+GTVG++GA++ LR+ LE  I     +   G+ VPVV  + EGG + I  + +
Sbjct: 243  SHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTVLE 302

Query: 970  YVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMVFP--ETDQE 1143
            Y+   P +P +VC+G+GRAAD++++  +     G         + + IK  F   +++
Sbjct: 303  YLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQSEAV 362

Query: 1144 EMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDL 1323
             +F+ + EC+ + +L+ +F  G E+ +D+D  IL+ +L+  N    +QL LTL+W+RVD+
Sbjct: 363  HLFQTMMECMKKKELITVFHIGSEDHQDIDVAILTALLKGTNASAFDQLILTLAWDRVDI 422

Query: 1324 AKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDD 1503
            AK+ +F  G++W    LE+AM DAL  DRV FV+ L+ENGVSM  FL+I RLE LYN
Sbjct: 423  AKNHVFVYGQQWLVGSLEQAMLDALVMDRVSFVKLLIENGVSMHKFLTIPRLEELYNTKQ 482

Query: 1504 INSA----HSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNAFQLYYTSRSFKGKY--- 1662
              +     H +R+  +   ++ P   +T+  IG V+E LMG  ++  YT + F+  Y
Sbjct: 483  GPTNPMLFHLIRDVKQG--NLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSL 540

Query: 1663 -----------------------------DRYKRINQSSY------FHRKRKIVQKELFK 1737
                                         D+ +++  + +      +  K     +E  K
Sbjct: 541  GGNNRRSGRNTSSSTPQLRKSHETFGNRADKKEKMRHNHFIKTAQPYRPKMDASMEEGKK 600

Query: 1738 KKSDDQIND-NEEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYK 1914
            K++ D+I D ++ E   F YP N+LLIWA L  R  MA  +W HGE++MAK L+A ++Y+
Sbjct: 601  KRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYR 660

Query: 1915 ATAKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNN 2094
            + A  A+   L  + ++ L   +    + A+ELL+Q +R D    ++LL  EL +W N+
Sbjct: 661  SMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNST 720

Query: 2095 CLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKH 2274
            CL LAV +  + F+AH C Q+LL+++W G L +R  S  +V+ +++ PPAIL + YK K
Sbjct: 721  CLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILMLEYKTKA 780

Query: 2275 SKTARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRK 2454
              +    S++           +T   S    ++   E   E   E      K+   S  K
Sbjct: 781  EMSHIPQSQDA--------HQMTMEDSENNFHNITEEIPMEVFKE-----VKILDSSDGK 827

Query: 2455 NXXXXXXXXXXXXXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLE 2634
            N                +  +L    +F AFY +PI KFW   +A+L FL   T ++L++
Sbjct: 828  NEMEIHI----------KSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVK 877

Query: 2635 TSLKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLV 2814
                PS  EWI   Y  T ++E +R++  SE  +I++K+KV+++ ++N+  + A++ F V
Sbjct: 878  MEQLPSVQEWIVIAYIFTYAIEKVREVFMSEAGKISQKIKVWFSDYFNVSDTIAIISFFV 937

Query: 2815 GYGFRLVPMYRH---------SWGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMV 2967
            G+G R    + +           GR++   + + +Y+++ ++L+V+   GPY+ M  KMV
Sbjct: 938  GFGLRFGAKWNYINAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMV 997

Query: 2968 WSMCYICVLLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEIDTC 3147
             +M YI V++ + L++FGV R+A+  P+ ++  W L ++I + PY+M++GEVYA EID C
Sbjct: 998  ANMFYIVVIMALVLLSFGVPRKAILYPH-EEPSWSLAKDIVFHPYWMIFGEVYAYEIDVC 1056

Query: 3148 GDEGIR---CFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRY 3318
             ++      C PG ++ P L                       Y      S  +W +QRY
Sbjct: 1057 ANDSTLPTICGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRY 1116

Query: 3319 QQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRRPDTKRFRSEHSIKLSVTEDEMKRIQD 3498
              +M YH+ P LPPP  I +H+      +   R+ D    ++    KL +TE++ K++ D
Sbjct: 1117 HFIMAYHEKPVLPPPLIILSHIVSLFCCVCKRRKKD----KTSDGPKLFLTEEDQKKLHD 1172

Query: 3499 FEEDCIDTLTRIRKLKLN--TKEPLSVT-DLTELTCQRVHDLMQENFLLKSRVYDIETKI 3669
            FEE C++     +  K N  ++E + VT +  E    ++ ++      +K  +  ++++I
Sbjct: 1173 FEEQCVEMYFDEKDDKFNSGSEERIRVTFERVEQMSIQIKEVGDRVNYIKRSLQSLDSQI 1232

Query: 3670 DHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEVPKITKTL-IDCHLSPVSIED 3837
             H+ + S   V  LK     +   AS +          +IT+ L I  HL+   I+D
Sbjct: 1233 GHLQDLSALTVDTLKTLTAQKASEASKVH--------NEITRELSISKHLAQNLIDD 1281


>gi|14009344|gb|AAK50377.1| LTRPC7 [Mus musculus]
          Length = 1863

 Score =  691 bits (1783), Expect = 0.0
 Identities = 427/1317 (32%), Positives = 699/1317 (52%), Gaps = 82/1317 (6%)
 Frame = +1

Query: 133  WIENTFEKRECIRFAALPKDPERC-------------GCGRPLSAHT--PASTFFSTLPV 267
            WIE+T  KREC+      KDP RC              CGR +  H    AS       V
Sbjct: 6    WIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMKYSDV 65

Query: 268  HLLEKEQQT---WTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLME 438
             L E   Q    W++  +T+ S TDA+G I FQGG+H+++A+YVRLSYD++P  ++ L+
Sbjct: 66   KLGEHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEIILQLLL 125

Query: 439  KVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVA 618
            K W +E P+LVI+VHGGM  FEL  R+ +L  KG++KAA TTGAWI+T G+++GV +HV
Sbjct: 126  KEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVAKHVG 185

Query: 619  KALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRH 798
             AL E   ++R   +I TIGIAPWGVI+ +  L+ ++    Y    L+  + + +LN+ H
Sbjct: 186  DALKEH--ASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQT-LLNPLSKLNVLNNLH 242

Query: 799  SYFLLADNGTVGRFGADLHLRQNLENHIATFGCN---GRKVPVVCTLLEGGISSINAIHD 969
            S+F+L D+GTVG++GA++ LR+ LE  I     +   G+ VPVV  + EGG + I  + +
Sbjct: 243  SHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTVLE 302

Query: 970  YVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMVFP--ETDQE 1143
            Y+   P +P +VC+G+GRAAD++++  +     G         + + IK  F   +++
Sbjct: 303  YLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQSEAV 362

Query: 1144 EMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDL 1323
             +F+ + EC+ + +L+ +F  G E+ +D+D  IL+ +L+  N    +QL LTL+W+RVD+
Sbjct: 363  HLFQTMMECMKKKELITVFHIGSEDHQDIDVAILTALLKGTNASAFDQLILTLAWDRVDI 422

Query: 1324 AKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDD 1503
            AK+ +F  G++W    LE+AM DAL  DRV FV+ L+ENGVSM  FL+I RLE LYN
Sbjct: 423  AKNHVFVYGQQWLVGSLEQAMLDALVMDRVSFVKLLIENGVSMHKFLTIPRLEELYNTKQ 482

Query: 1504 INSA----HSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNAFQLYYTSRSFKGKY--- 1662
              +     H +R+  +   ++ P   +T+  IG V+E LMG  ++  YT + F+  Y
Sbjct: 483  GPTNPMLFHLIRDVKQG--NLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSL 540

Query: 1663 -----------------------------DRYKRINQSSY------FHRKRKIVQKELFK 1737
                                         D+ +++  + +      +  K     +E  K
Sbjct: 541  GGNNRRSGRNTSSSTPQLRKSHETFGNRADKKEKMRHNHFIKTAQPYRPKMDASMEEGKK 600

Query: 1738 KKSDDQIND-NEEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYK 1914
            K++ D+I D ++ E   F YP N+LLIWA L  R  MA  +W HGE++MAK L+A ++Y+
Sbjct: 601  KRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYR 660

Query: 1915 ATAKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNN 2094
            + A  A+   L  + ++ L   +    + A+ELL+Q +R D    ++LL  EL +W N+
Sbjct: 661  SMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNST 720

Query: 2095 CLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKH 2274
            CL LAV +  + F+AH C Q+LL+++W G L +R  S  +V+ +++ PPAIL + YK K
Sbjct: 721  CLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILMLEYKTKA 780

Query: 2275 SKTARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRK 2454
              +    S++           +T   S    ++   E   E   E      K+   S  K
Sbjct: 781  EMSHIPQSQDA--------HQMTMEDSENNFHNITEEIPMEVFKE-----VKILDSSDGK 827

Query: 2455 NXXXXXXXXXXXXXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLE 2634
            N                +  +L    +F AFY +PI KFW   +A+L FL   T ++L++
Sbjct: 828  NEMEIHI----------KSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVK 877

Query: 2635 TSLKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLV 2814
                PS  EWI   Y  T ++E +R++  SE  +I++K+KV+++ ++N+  + A++ F V
Sbjct: 878  MEQLPSVQEWIVIAYIFTYAIEKVREVFMSEAGKISQKIKVWFSDYFNVSDTIAIISFFV 937

Query: 2815 GYGFRLVPMYRH---------SWGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMV 2967
            G+G R    + +           GR++   + + +Y+++ ++L+V+   GPY+ M  KMV
Sbjct: 938  GFGLRFGAKWNYINAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMV 997

Query: 2968 WSMCYICVLLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEIDTC 3147
             +M YI V++ + L++FGV R+A+  P+ ++  W L ++I + PY+M++GEVYA EID C
Sbjct: 998  ANMFYIVVIMALVLLSFGVPRKAILYPH-EEPSWSLAKDIVFHPYWMIFGEVYAYEIDVC 1056

Query: 3148 GDEGIR---CFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRY 3318
             ++      C PG ++ P L                       Y      S  +W +QRY
Sbjct: 1057 ANDSTLPTICGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRY 1116

Query: 3319 QQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRRPDTKRFRSEHSIKLSVTEDEMKRIQD 3498
              +M YH+ P LPPP  I +H+      +   R+ D    ++    KL +TE++ K++ D
Sbjct: 1117 HFIMAYHEKPVLPPPLIILSHIVSLFCCVCKRRKKD----KTSDGPKLFLTEEDQKKLHD 1172

Query: 3499 FEEDCIDTLTRIRKLKLN--TKEPLSVT-DLTELTCQRVHDLMQENFLLKSRVYDIETKI 3669
            FEE C++     +  K N  ++E + VT +  E    ++ ++      +K  +  ++++I
Sbjct: 1173 FEEQCVEMYFDEKDDKFNSGSEERIRVTFERVEQMSIQIKEVGDRVNYIKRSLQSLDSQI 1232

Query: 3670 DHISNSSDEVVQILKNKKLSQNFAASSLSLPDTSIEVPKITKTL-IDCHLSPVSIED 3837
             H+ + S   V  LK     +   AS +          +IT+ L I  HL+   I+D
Sbjct: 1233 GHLQDLSALTVDTLKTLTAQKASEASKVH--------NEITRELSISKHLAQNLIDD 1281


>gi|45935360|ref|NP_996827.1| transient receptor potential cation
            channel, subfamily M, member 3 isoform d; melastatin 2;
            long transient receptor potential channel 3 [Homo
            sapiens]
 gi|28626253|gb|AAO49156.1| calcium-permeable store-operated channel
            TRPM3d [Homo sapiens]
          Length = 1544

 Score =  687 bits (1772), Expect = 0.0
 Identities = 394/1123 (35%), Positives = 637/1123 (56%), Gaps = 23/1123 (2%)
 Frame = +1

Query: 385  YVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTT 564
            YVR+S+D++P  +++LM K W LE P+L+I+VHGG+ NFEL+ +L ++F KG++KAA TT
Sbjct: 2    YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 565  GAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYY 744
            GAWI T G+++GV+RHV  AL +   +++ R +I TIGIAPWG+++ +E LI ++    Y
Sbjct: 62   GAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPY 119

Query: 745  DVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN---GRKVP 915
               S  ++  + +LN  HS+F+LADNGT G++GA++ LR+ LE HI+    N   G+ VP
Sbjct: 120  QTMSNPMS-KLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVP 178

Query: 916  VVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGE 1095
            VV  ++EGG + I+ + +Y+   P +P +VCDGSGRA+DI++F  +Y    G     + +
Sbjct: 179  VVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRD 238

Query: 1096 KLRNLIKMVFP--ETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQN 1269
            +L   I+  F    T  + +F  + EC+ + +L+ +FR G E  +D+D  IL+ +L+  N
Sbjct: 239  QLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGAN 298

Query: 1270 LPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVS 1449
                +QL+L L+WNRVD+A+S +F  G++W    LE+AM DAL  DRVDFV+ L+ENGVS
Sbjct: 299  ASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVS 358

Query: 1450 MKNFLSINRLENLYNMDDINSA---HSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNA 1620
            M  FL+I+RLE LYN     S    H VR+  +   ++ P   +++  IG V+E LMG A
Sbjct: 359  MHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKG--NLPPDYRISLIDIGLVIEYLMGGA 416

Query: 1621 FQLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPF 1800
            ++  YT + F+  Y       +     R+ +   K   K++ +  I+ ++ E   F +PF
Sbjct: 417  YRCNYTRKRFRTLYHNLFGPKRDDIPLRRGRKTTK---KREEEVDIDLDDPEINHFPFPF 473

Query: 1801 NDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDN 1980
            ++L++WAVL  R  MA   W HGE+AMAK L+A +L KA A  A +  +  + ++ L  N
Sbjct: 474  HELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHN 533

Query: 1981 AVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQIL 2160
            +    + A+ELLDQ Y+ D    ++LL  EL +W N  CL LAV A  + F+AH C Q+L
Sbjct: 534  SRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQML 593

Query: 2161 LAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESI 2340
            L ++W G L++R  S ++V+  ++ PP+IL + +K K             + +PY
Sbjct: 594  LTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNK-------------DDMPY----- 635

Query: 2341 TSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXXFKREPQL 2520
             S     +   K  EE ++   EK     ++T +  R N                R   L
Sbjct: 636  MSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPL 695

Query: 2521 NKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVE 2700
             +  +   FY++PI KFW + +A++ +L     I+L++    PS  EWI   Y  TL +E
Sbjct: 696  GR--KIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIE 753

Query: 2701 HIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFS 2880
             +R+++ SE  ++ +KVKV+  +++N+    A+L F VG   RL      S GRV+   +
Sbjct: 754  KMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVN 813

Query: 2881 NVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKD 3060
             + +Y+++ +   V+  LGPY+ M  KM+  M Y  +++LV LM+FGV RQA+  PN ++
Sbjct: 814  IIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPN-EE 872

Query: 3061 WHWLLVRNIFYKPYFMLYGEVYAGEID-TCGDEGIR----------CFPGYFIPPLLMXX 3207
              W L +NIFY PY+M+YGEV+A +ID  CG    R          C  G +I P +M
Sbjct: 873  PSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMAC 932

Query: 3208 XXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVY 3387
                                + +    S ++W FQRYQ +M +H+ P LPPP  IF+H+
Sbjct: 933  YLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMT 992

Query: 3388 HFIDYL-YNLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTK-- 3558
                +L    R+ ++     ++ +KL +T+DE+K++ DFEE CI+   R +  + N+
Sbjct: 993  MIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSND 1052

Query: 3559 EPLSVT-DLTELTCQRVHDLMQENFLLKSRVYDIETKIDHISN 3684
            E + VT +  E    R+ ++ +    +K+ +  ++ ++  + +
Sbjct: 1053 ERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLED 1095


>gi|27597209|dbj|BAC55104.1| hypothetical protein [Homo sapiens]
          Length = 1544

 Score =  687 bits (1772), Expect = 0.0
 Identities = 394/1123 (35%), Positives = 637/1123 (56%), Gaps = 23/1123 (2%)
 Frame = +1

Query: 385  YVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTT 564
            YVR+S+D++P  +++LM K W LE P+L+I+VHGG+ NFEL+ +L ++F KG++KAA TT
Sbjct: 2    YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 565  GAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYY 744
            GAWI T G+++GV+RHV  AL +   +++ R +I TIGIAPWG+++ +E LI ++    Y
Sbjct: 62   GAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPY 119

Query: 745  DVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN---GRKVP 915
               S  ++  + +LN  HS+F+LADNGT G++GA++ LR+ LE HI+    N   G+ VP
Sbjct: 120  QTMSNPMS-KLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVP 178

Query: 916  VVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGE 1095
            VV  ++EGG + I+ + +Y+   P +P +VCDGSGRA+DI++F  +Y    G     + +
Sbjct: 179  VVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRD 238

Query: 1096 KLRNLIKMVFP--ETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQN 1269
            +L   I+  F    T  + +F  + EC+ + +L+ +FR G E  +D+D  IL+ +L+  N
Sbjct: 239  QLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGAN 298

Query: 1270 LPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVS 1449
                +QL+L L+WNRVD+A+S +F  G++W    LE+AM DAL  DRVDFV+ L+ENGVS
Sbjct: 299  ASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVS 358

Query: 1450 MKNFLSINRLENLYNMDDINSA---HSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNA 1620
            M  FL+I+RLE LYN     S    H VR+  +   ++ P   +++  IG V+E LMG A
Sbjct: 359  MHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKG--NLPPDYRISLIDIGLVIEYLMGGA 416

Query: 1621 FQLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPF 1800
            ++  YT + F+  Y       +     R+ +   K   K++ +  I+ ++ E   F +PF
Sbjct: 417  YRCNYTRKRFRTLYHNLFGPKRDDIPLRRGRKTTK---KREEEVDIDLDDPEINHFPFPF 473

Query: 1801 NDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDN 1980
            ++L++WAVL  R  MA   W HGE+AMAK L+A +L KA A  A +  +  + ++ L  N
Sbjct: 474  HELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHN 533

Query: 1981 AVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQIL 2160
            +    + A+ELLDQ Y+ D    ++LL  EL +W N  CL LAV A  + F+AH C Q+L
Sbjct: 534  SRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQML 593

Query: 2161 LAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESI 2340
            L ++W G L++R  S ++V+  ++ PP+IL + +K K             + +PY
Sbjct: 594  LTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNK-------------DDMPY----- 635

Query: 2341 TSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXXFKREPQL 2520
             S     +   K  EE ++   EK     ++T +  R N                R   L
Sbjct: 636  MSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPL 695

Query: 2521 NKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVE 2700
             +  +   FY++PI KFW + +A++ +L     I+L++    PS  EWI   Y  TL +E
Sbjct: 696  GR--KIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIE 753

Query: 2701 HIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFS 2880
             +R+++ SE  ++ +KVKV+  +++N+    A+L F VG   RL      S GRV+   +
Sbjct: 754  KMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVN 813

Query: 2881 NVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKD 3060
             + +Y+++ +   V+  LGPY+ M  KM+  M Y  +++LV LM+FGV RQA+  PN ++
Sbjct: 814  IIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPN-EE 872

Query: 3061 WHWLLVRNIFYKPYFMLYGEVYAGEID-TCGDEGIR----------CFPGYFIPPLLMXX 3207
              W L +NIFY PY+M+YGEV+A +ID  CG    R          C  G +I P +M
Sbjct: 873  PSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMAC 932

Query: 3208 XXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVY 3387
                                + +    S ++W FQRYQ +M +H+ P LPPP  IF+H+
Sbjct: 933  YLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMT 992

Query: 3388 HFIDYL-YNLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTK-- 3558
                +L    R+ ++     ++ +KL +T+DE+K++ DFEE CI+   R +  + N+
Sbjct: 993  MIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSND 1052

Query: 3559 EPLSVT-DLTELTCQRVHDLMQENFLLKSRVYDIETKIDHISN 3684
            E + VT +  E    R+ ++ +    +K+ +  ++ ++  + +
Sbjct: 1053 ERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLED 1095


>gi|45935362|ref|NP_996828.1| transient receptor potential cation
            channel, subfamily M, member 3 isoform e; melastatin 2;
            long transient receptor potential channel 3 [Homo
            sapiens]
 gi|28626255|gb|AAO49157.1| calcium-permeable store-operated channel
            TRPM3e [Homo sapiens]
          Length = 1556

 Score =  686 bits (1770), Expect = 0.0
 Identities = 395/1133 (34%), Positives = 638/1133 (55%), Gaps = 33/1133 (2%)
 Frame = +1

Query: 385  YVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTT 564
            YVR+S+D++P  +++LM K W LE P+L+I+VHGG+ NFEL+ +L ++F KG++KAA TT
Sbjct: 2    YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 565  GAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYY 744
            GAWI T G+++GV+RHV  AL +   +++ R +I TIGIAPWG+++ +E LI ++    Y
Sbjct: 62   GAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPY 119

Query: 745  DVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN---GRKVP 915
               S  ++  + +LN  HS+F+LADNGT G++GA++ LR+ LE HI+    N   G+ VP
Sbjct: 120  QTMSNPMS-KLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVP 178

Query: 916  VVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGE 1095
            VV  ++EGG + I+ + +Y+   P +P +VCDGSGRA+DI++F  +Y    G     + +
Sbjct: 179  VVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRD 238

Query: 1096 KLRNLIKMVFP--ETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQN 1269
            +L   I+  F    T  + +F  + EC+ + +L+ +FR G E  +D+D  IL+ +L+  N
Sbjct: 239  QLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGAN 298

Query: 1270 LPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVS 1449
                +QL+L L+WNRVD+A+S +F  G++W    LE+AM DAL  DRVDFV+ L+ENGVS
Sbjct: 299  ASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVS 358

Query: 1450 MKNFLSINRLENLYNMDDINSA---HSVRN----------WMENFDSMDPHTYLTIPMIG 1590
            M  FL+I+RLE LYN     S    H VR+          W+    ++ P   +++  IG
Sbjct: 359  MHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIG 418

Query: 1591 QVVEKLMGNAFQLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDNE 1770
             V+E LMG A++  YT + F+  Y       +     R+ +   K   K++ +  I+ ++
Sbjct: 419  LVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDIPLRRGRKTTK---KREEEVDIDLDD 475

Query: 1771 EEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLD 1950
             E   F +PF++L++WAVL  R  MA   W HGE+AMAK L+A +L KA A  A +  +
Sbjct: 476  PEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMV 535

Query: 1951 VEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKT 2130
             + ++ L  N+    + A+ELLDQ Y+ D    ++LL  EL +W N  CL LAV A  +
Sbjct: 536  DDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRD 595

Query: 2131 FLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETP 2310
            F+AH C Q+LL ++W G L++R  S ++V+  ++ PP+IL + +K K
Sbjct: 596  FIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNK------------- 642

Query: 2311 EQLPYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXX 2490
            + +PY      S     +   K  EE ++   EK     ++T +  R N
Sbjct: 643  DDMPY-----MSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEE 697

Query: 2491 XXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWIT 2670
                 R   L +  +   FY++PI KFW + +A++ +L     I+L++    PS  EWI
Sbjct: 698  VQSKHRLIPLGR--KIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIV 755

Query: 2671 FIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRH 2850
              Y  TL +E +R+++ SE  ++ +KVKV+  +++N+    A+L F VG   RL
Sbjct: 756  ISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFR 815

Query: 2851 SWGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNR 3030
            S GRV+   + + +Y+++ +   V+  LGPY+ M  KM+  M Y  +++LV LM+FGV R
Sbjct: 816  SDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVAR 875

Query: 3031 QALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEID-TCGDEGIR----------CFPG 3177
            QA+  PN ++  W L +NIFY PY+M+YGEV+A +ID  CG    R          C  G
Sbjct: 876  QAILFPN-EEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTG 934

Query: 3178 YFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLP 3357
             +I P +M                      + +    S ++W FQRYQ +M +H+ P LP
Sbjct: 935  AWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLP 994

Query: 3358 PPFSIFAHVYHFIDYL-YNLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRI 3534
            PP  IF+H+     +L    R+ ++     ++ +KL +T+DE+K++ DFEE CI+   R
Sbjct: 995  PPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFRE 1054

Query: 3535 RKLKLNTK--EPLSVT-DLTELTCQRVHDLMQENFLLKSRVYDIETKIDHISN 3684
            +  + N+   E + VT +  E    R+ ++ +    +K+ +  ++ ++  + +
Sbjct: 1055 KDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLED 1107


>gi|47214200|emb|CAG00828.1| unnamed protein product [Tetraodon
            nigroviridis]
          Length = 2135

 Score =  685 bits (1767), Expect = 0.0
 Identities = 421/1317 (31%), Positives = 692/1317 (51%), Gaps = 109/1317 (8%)
 Frame = +1

Query: 130  PWIENTFEKRECIRFAALPKDPERC-------------GCGRPLSAHTPASTFFSTL--- 261
            PWIE+TF KREC+    + KDP RC              CGR +  H   +   ++
Sbjct: 94   PWIESTFSKRECVYILPVSKDPHRCLPGCQICQQLVRCCCGRLVRQHVGFTASLASKYSD 153

Query: 262  -----PVHLLEKEQQTWTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVM 426
                  V L     + W++  +T+ S TDA+G I FQGG+H+++A+Y RLSYD+ P  ++
Sbjct: 154  VKLGENVGLPTPAAEEWSVEKHTEASPTDAYGVINFQGGSHSYRAKYARLSYDTRPECIL 213

Query: 427  YLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVV 606
             LM K W +E P+++I+VHGG+ NFEL  R+ ++  KG++ AA TTGAWI+T G+++GV
Sbjct: 214  RLMLKEWQMELPKILISVHGGVQNFELHPRIKQVVGKGLINAAVTTGAWILTGGVNTGVA 273

Query: 607  RHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGIL 786
            +HV  AL E    +R   +I TIGIAPWGVI+ +  L+ ++    Y    L+  + +  L
Sbjct: 274  KHVGDALKEH--FSRSSKKICTIGIAPWGVIENRNDLLGRDIIAPYQT-LLNPLSKLNAL 330

Query: 787  NDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN---GRKVPVVCTLLEGGISSIN 957
            N  HS+FLL D+GTVGR+GA+++LR+ LE HI     +   G+ VPVV  + EGG + I
Sbjct: 331  NSLHSHFLLVDDGTVGRYGAEVNLRRQLEKHINLQRIHARIGQGVPVVALIFEGGPNVIL 390

Query: 958  AIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMV--FPE 1131
             + +Y+   P +P +VC+G+GRAADI+++  +     G     V   +   IK    F +
Sbjct: 391  TVLEYLQESPPVPVVVCEGTGRAADILAYVHKQTEERGRLPDGVEADIIATIKKTFNFSQ 450

Query: 1132 TDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWN 1311
            +D   +F+ + EC+   +L+ +F    EE +D+D  IL  +L+  N    +QL LTL+W+
Sbjct: 451  SDAIHLFQTLMECMKSKELITVFHISSEEHQDIDVAILRALLKGTNASAFDQLVLTLAWD 510

Query: 1312 RVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLY 1491
            RVD+AK+ +F  G++     LE+AM DAL  DRVDFV+ L+ENGVSM  FL+I+RLE LY
Sbjct: 511  RVDIAKNHVFVYGQQLLVSSLEQAMLDALVMDRVDFVKLLIENGVSMHRFLTISRLEELY 570

Query: 1492 NM----DDINSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNAFQLYYTSRSFKGK 1659
            N     ++ N  H VR+  ++   + P+  +T+  IG V+E LMG  ++  YT + F+
Sbjct: 571  NTKQPGNNPNLLHLVRDVKQS--HLPPNYKITLIDIGLVIEYLMGGTYRCNYTRKRFRII 628

Query: 1660 YDRYKRINQSSYFH-------------------RKRKIVQKELFK--------------- 1737
            Y+  +  ++ S  H                   +K K    +  K
Sbjct: 629  YNNLRGNSRRSGRHSAPGSHLRRNHETFSMEADKKEKTRHNQFIKTAQPYKPKLESSSEQ 688

Query: 1738 --KKSDDQIND-NEEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRL 1908
              K+S ++I D ++ E   F YPFN+LL+WAVL  R  M+   W HGE+ MAK L+A +L
Sbjct: 689  KTKRSKEEIVDIDDPETRRFPYPFNELLVWAVLMKRQKMSLFFWQHGEENMAKALVACKL 748

Query: 1909 YKATAKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGN 2088
            Y++    A+   +  + ++ L + + +    A++LL+Q +R D    ++LL  EL +W N
Sbjct: 749  YRSMGYEAKKSDVVDDASEELKEYSNEFGTLAVDLLEQSFRQDETMAMKLLTYELKNWSN 808

Query: 2089 NNCLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKP 2268
            + CL LAV ++ + F+AH C Q+LL+++W G L +R  S  +V+ +++ PPAIL + YK
Sbjct: 809  STCLKLAVSSHLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKS 868

Query: 2269 KHSKTARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISS 2448
            K ++ A +   +   Q+       T   S     S   + Q +   E  S+
Sbjct: 869  K-AEMAHIPQSQDDHQM-------TMEDSENNFQSGADDIQMDVFKESRSHDH-----ME 915

Query: 2449 RKNXXXXXXXXXXXXXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILL 2628
             KN                R  +L    +  AFY +PI KFWS  + +L FL   + ++L
Sbjct: 916  AKNEAETQF----------RSRKLPLTRKIYAFYRAPIVKFWSNTLFYLGFLMLYSYVVL 965

Query: 2629 LETSLKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFF 2808
            ++   +PS  EW+  +Y  T ++E IR++  SE  +I++K+KV++++++NI    A++ F
Sbjct: 966  VKMPEQPSPQEWVVILYIFTSAIEKIREMFMSEAGKISQKIKVWFSEYFNICDFLAIITF 1025

Query: 2809 LVGYGFRLVPMYRHSWGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVW------ 2970
             +G+G RL      + GR++   + + +Y+++ + L+V+   GPY+ M AKMV
Sbjct: 1026 FIGFGLRLAGGEVFTPGRLVYCLNIIFWYVRLMDILAVNQQAGPYVMMIAKMVLEAIFTS 1085

Query: 2971 --------SMCYICVLLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVY 3126
                    +M YI V++ + L++FGV R+A+  P+ ++  W L +++ ++PY+M+YGEVY
Sbjct: 1086 HRHLFQVANMFYIVVIMAIVLLSFGVPRKAILYPD-EEPSWTLAKDVIFQPYWMMYGEVY 1144

Query: 3127 AGEIDTCGD-----EGIRCFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKS 3291
            A EID C +         C  G F+ PLL                       Y      S
Sbjct: 1145 AYEIDVCANNTEPLSKQLCATGVFLTPLLQAVYLFVQYILMVNLLIAFFNNVYLQVKSIS 1204

Query: 3292 KEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRRPDT-KRFRSEHSI---- 3456
              +W +QRY  +M YH+ P LPPP  +  HVY         ++  T     +E  +
Sbjct: 1205 NLVWKYQRYHFIMVYHEKPVLPPPVILLCHVYSLFCMCRKRKKESTYGPSMAEDQVSPPE 1264

Query: 3457 ---------------KLSVTEDEMKRIQDFEEDCIDTLTRIR--KLKLNTKEPLSVT-DL 3582
                           +L +TE++ K++ DFEE C++     +  +    ++E + VT +
Sbjct: 1265 PKPTTPLINALLFLPELFLTEEDRKKLHDFEEQCVEAYFHEKDDQFHSGSEERIRVTSER 1324

Query: 3583 TELTCQRVHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILKNKKLSQNFAASSL 3753
             E  C ++ ++  +   +K  ++ ++++I H+ + S   V  LK     +   AS +
Sbjct: 1325 VESMCMQLREVGNKVTFIKRSLHALDSQIGHLQDLSVLTVDTLKTLTAQRASEASKV 1381


>gi|28274684|ref|NP_066003.1| transient receptor potential cation
            channel, subfamily M, member 3 isoform a; melastatin 2;
            long transient receptor potential channel 3 [Homo
            sapiens]
 gi|27597205|dbj|BAC55102.1| hypothetical protein [Homo sapiens]
 gi|28626247|gb|AAO49153.1| calcium-permeable store-operated channel
            TRPM3a [Homo sapiens]
          Length = 1554

 Score =  684 bits (1765), Expect = 0.0
 Identities = 396/1130 (35%), Positives = 638/1130 (56%), Gaps = 30/1130 (2%)
 Frame = +1

Query: 385  YVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTT 564
            YVR+S+D++P  +++LM K W LE P+L+I+VHGG+ NFEL+ +L ++F KG++KAA TT
Sbjct: 2    YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 565  GAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYY 744
            GAWI T G+++GV+RHV  AL +   +++ R +I TIGIAPWG+++ +E LI ++    Y
Sbjct: 62   GAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPY 119

Query: 745  DVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN---GRKVP 915
               S  ++  + +LN  HS+F+LADNGT G++GA++ LR+ LE HI+    N   G+ VP
Sbjct: 120  QTMSNPMS-KLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVP 178

Query: 916  VVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGE 1095
            VV  ++EGG + I+ + +Y+   P +P +VCDGSGRA+DI++F  +Y    G     + +
Sbjct: 179  VVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRD 238

Query: 1096 KLRNLIKMVFP--ETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQN 1269
            +L   I+  F    T  + +F  + EC+ + +L+ +FR G E  +D+D  IL+ +L+  N
Sbjct: 239  QLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGAN 298

Query: 1270 LPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVS 1449
                +QL+L L+WNRVD+A+S +F  G++W    LE+AM DAL  DRVDFV+ L+ENGVS
Sbjct: 299  ASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVS 358

Query: 1450 MKNFLSINRLENLYNMDDINSA---HSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNA 1620
            M  FL+I+RLE LYN     S    H VR+  +   ++ P   +++  IG V+E LMG A
Sbjct: 359  MHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKG--NLPPDYRISLIDIGLVIEYLMGGA 416

Query: 1621 FQLYYTSRSFKGKYDRY---KRINQSSYFHRKRKIV----QKELFKKKSDDQINDNEEED 1779
            ++  YT + F+  Y      KR         +  I     +K   K++ +  I+ ++ E
Sbjct: 417  YRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIPLRRGRKTTKKREEEVDIDLDDPEI 476

Query: 1780 FSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEE 1959
              F +PF++L++WAVL  R  MA   W HGE+AMAK L+A +L KA A  A +  +  +
Sbjct: 477  NHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDI 536

Query: 1960 AKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLA 2139
            ++ L  N+    + A+ELLDQ Y+ D    ++LL  EL +W N  CL LAV A  + F+A
Sbjct: 537  SQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIA 596

Query: 2140 HPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQL 2319
            H C Q+LL ++W G L++R  S ++V+  ++ PP+IL + +K K             + +
Sbjct: 597  HTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNK-------------DDM 643

Query: 2320 PYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXX 2499
            PY      S     +   K  EE ++   EK     ++T +  R N
Sbjct: 644  PY-----MSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQS 698

Query: 2500 FKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIY 2679
              R   L +  +   FY++PI KFW + +A++ +L     I+L++    PS  EWI   Y
Sbjct: 699  KHRLIPLGR--KIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISY 756

Query: 2680 TVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWG 2859
              TL +E +R+++ SE  ++ +KVKV+  +++N+    A+L F VG   RL      S G
Sbjct: 757  IFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDG 816

Query: 2860 RVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQAL 3039
            RV+   + + +Y+++ +   V+  LGPY+ M  KM+  M Y  +++LV LM+FGV RQA+
Sbjct: 817  RVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAI 876

Query: 3040 TEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEID-TCGDEGIR----------CFPGYFI 3186
              PN ++  W L +NIFY PY+M+YGEV+A +ID  CG    R          C  G +I
Sbjct: 877  LFPN-EEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWI 935

Query: 3187 PPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPF 3366
             P +M                      + +    S ++W FQRYQ +M +H+ P LPPP
Sbjct: 936  VPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPL 995

Query: 3367 SIFAHVYHFIDYL-YNLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKL 3543
             IF+H+     +L    R+ ++     ++ +KL +T+DE+K++ DFEE CI+   R +
Sbjct: 996  IIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDD 1055

Query: 3544 KLNTK--EPLSVT-DLTELTCQRVHDLMQENFLLKSRVYDIETKIDHISN 3684
            + N+   E + VT +  E    R+ ++ +    +K+ +  ++ ++  + +
Sbjct: 1056 RFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLED 1105


>gi|45935358|ref|NP_079247.3| transient receptor potential cation
            channel, subfamily M, member 3 isoform b; melastatin 2;
            long transient receptor potential channel 3 [Homo
            sapiens]
 gi|28626249|gb|AAO49154.1| calcium-permeable store-operated channel
            TRPM3b [Homo sapiens]
          Length = 1566

 Score =  683 bits (1763), Expect = 0.0
 Identities = 397/1140 (34%), Positives = 639/1140 (55%), Gaps = 40/1140 (3%)
 Frame = +1

Query: 385  YVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTT 564
            YVR+S+D++P  +++LM K W LE P+L+I+VHGG+ NFEL+ +L ++F KG++KAA TT
Sbjct: 2    YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 565  GAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYY 744
            GAWI T G+++GV+RHV  AL +   +++ R +I TIGIAPWG+++ +E LI ++    Y
Sbjct: 62   GAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPY 119

Query: 745  DVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN---GRKVP 915
               S  ++  + +LN  HS+F+LADNGT G++GA++ LR+ LE HI+    N   G+ VP
Sbjct: 120  QTMSNPMS-KLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVP 178

Query: 916  VVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGE 1095
            VV  ++EGG + I+ + +Y+   P +P +VCDGSGRA+DI++F  +Y    G     + +
Sbjct: 179  VVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRD 238

Query: 1096 KLRNLIKMVFP--ETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQN 1269
            +L   I+  F    T  + +F  + EC+ + +L+ +FR G E  +D+D  IL+ +L+  N
Sbjct: 239  QLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGAN 298

Query: 1270 LPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVS 1449
                +QL+L L+WNRVD+A+S +F  G++W    LE+AM DAL  DRVDFV+ L+ENGVS
Sbjct: 299  ASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVS 358

Query: 1450 MKNFLSINRLENLYNMDDINSA---HSVRN----------WMENFDSMDPHTYLTIPMIG 1590
            M  FL+I+RLE LYN     S    H VR+          W+    ++ P   +++  IG
Sbjct: 359  MHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIG 418

Query: 1591 QVVEKLMGNAFQLYYTSRSFKGKYDRY---KRINQSSYFHRKRKIV----QKELFKKKSD 1749
             V+E LMG A++  YT + F+  Y      KR         +  I     +K   K++ +
Sbjct: 419  LVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIPLRRGRKTTKKREEE 478

Query: 1750 DQINDNEEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKI 1929
              I+ ++ E   F +PF++L++WAVL  R  MA   W HGE+AMAK L+A +L KA A
Sbjct: 479  VDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHE 538

Query: 1930 AEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLA 2109
            A +  +  + ++ L  N+    + A+ELLDQ Y+ D    ++LL  EL +W N  CL LA
Sbjct: 539  ASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLA 598

Query: 2110 VLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTAR 2289
            V A  + F+AH C Q+LL ++W G L++R  S ++V+  ++ PP+IL + +K K
Sbjct: 599  VAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNK------ 652

Query: 2290 LLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXX 2469
                   + +PY      S     +   K  EE ++   EK     ++T +  R N
Sbjct: 653  -------DDMPY-----MSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESS 700

Query: 2470 XXXXXXXXXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKP 2649
                        R   L +  +   FY++PI KFW + +A++ +L     I+L++    P
Sbjct: 701  RKKDEEEVQSKHRLIPLGR--KIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWP 758

Query: 2650 SKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFR 2829
            S  EWI   Y  TL +E +R+++ SE  ++ +KVKV+  +++N+    A+L F VG   R
Sbjct: 759  STQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILR 818

Query: 2830 LVPMYRHSWGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPL 3009
            L      S GRV+   + + +Y+++ +   V+  LGPY+ M  KM+  M Y  +++LV L
Sbjct: 819  LQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVL 878

Query: 3010 MAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEID-TCGDEGIR------- 3165
            M+FGV RQA+  PN ++  W L +NIFY PY+M+YGEV+A +ID  CG    R
Sbjct: 879  MSFGVARQAILFPN-EEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQ 937

Query: 3166 ---CFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEY 3336
               C  G +I P +M                      + +    S ++W FQRYQ +M +
Sbjct: 938  LPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTF 997

Query: 3337 HDSPFLPPPFSIFAHVYHFIDYL-YNLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEEDC 3513
            H+ P LPPP  IF+H+     +L    R+ ++     ++ +KL +T+DE+K++ DFEE C
Sbjct: 998  HERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQC 1057

Query: 3514 IDTLTRIRKLKLNTK--EPLSVT-DLTELTCQRVHDLMQENFLLKSRVYDIETKIDHISN 3684
            I+   R +  + N+   E + VT +  E    R+ ++ +    +K+ +  ++ ++  + +
Sbjct: 1058 IEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLED 1117


>gi|34861963|ref|XP_219747.2| similar to transient receptor potential
            cation channel 6/channel-kinase 2 [Rattus norvegicus]
          Length = 1974

 Score =  681 bits (1756), Expect = 0.0
 Identities = 392/1169 (33%), Positives = 652/1169 (55%), Gaps = 40/1169 (3%)
 Frame = +1

Query: 133  WIENTFEKRECIRFAALPKDPERCGCGRPLSAHTPASTFFSTLPVHLLEKEQQTWTIANN 312
            WIE  F KREC +F    KDP RC CGR +  H      +S         EQ  W++  +
Sbjct: 30   WIERVFYKRECNKFIPSSKDPHRCYCGRLIQEHQGLDRAWSLSATEGNGNEQ--WSVEKH 87

Query: 313  TQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGM 492
            T  S TD FGTI FQ G H + ++Y+R S+D++   +++LM K W +E P+LVI+VHGG+
Sbjct: 88   TVKSPTDTFGTINFQDGEHIYHSKYIRTSWDTKSDHLLHLMLKEWNMELPKLVISVHGGL 147

Query: 493  SNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVT 672
             NF++  +L   F +G++KAA+TTGAWIIT G++SGV +HV  AL +A  S  +R +I T
Sbjct: 148  QNFKMPSKLKETFSQGLVKAAETTGAWIITEGINSGVSKHVGDAL-KAHSSMSLR-KIWT 205

Query: 673  IGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADL 852
            +GI PWGVI+ +  L+ ++    Y   S  ++  +  LN  HS+F+L D+GTVG++G +
Sbjct: 206  VGIPPWGVIENQRELVGKDVVCMYQTLSNPLS-KLTTLNCMHSHFILCDDGTVGKYGNEE 264

Query: 853  HLRQNLENHIAT---FGCNGRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGR 1023
             LR+NLE H++      C+ + VPVV  ++EGG + I  + + V  K   P +VC+G+GR
Sbjct: 265  KLRRNLEKHLSMQKIHTCSRQGVPVVGLVVEGGPNVILWVWETVRNKE--PVVVCEGTGR 322

Query: 1024 AADIISFAARYINSDGTFAAEVGEKLRNLIKMVFPET--DQEEMFRKITECVIRDDLLRI 1197
            AAD+++F  ++    G    +V E++  LI+ +F  +    + +F+ + EC++  D + I
Sbjct: 323  AADLLAFTYKHSEDGGILRPQVKEEILCLIQNMFNFSLRQSKHLFQILMECMVHKDSITI 382

Query: 1198 FRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLE 1377
            F    EE +D+D  IL  +L+  +L   EQL L ++W+R+D+AK  +   G+ W    LE
Sbjct: 383  FDADSEEHQDLDLAILKALLKGTSLSISEQLNLAMAWDRMDIAKKHILIYGQHWKPGALE 442

Query: 1378 KAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDDINSAHSVRNWMENFDSMD 1557
            +AM DAL  DRVDFV+ L+ENGV++  FL+I+RLE+LYN     +   +R+ +++   +
Sbjct: 443  QAMRDALVMDRVDFVKLLIENGVNLHRFLTISRLEDLYNTKQGPTNKFLRHLVQD---VK 499

Query: 1558 PHTYL-----TIPMIGQVVEKLMGNAFQLYYTSRSFKGKY-DRYKR----INQSSYFHRK 1707
             HT L     T+  IG V+E L+G A++  YT +SF+  Y D Y++    ++Q      +
Sbjct: 500  QHTLLSSYRITLIDIGLVIEYLIGGAYRSSYTRKSFRVLYNDLYRKHKHPLHQRHSLGNR 559

Query: 1708 RKIVQKELF----------------------KKKSDDQINDNEEEDFS-FAYPFNDLLIW 1818
            ++  +  L                       KKKS ++ + +E+   + F YP+NDLL+W
Sbjct: 560  KESSESTLHSQFFRTAQPYKSKDKPEDSHKPKKKSKERHSLSEDPGSAGFIYPYNDLLVW 619

Query: 1819 AVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDNAVKCRE 1998
            AVL  R  MA   W HGE+A  K ++A  LY+A A+ A++  +  + ++ L   + +  +
Sbjct: 620  AVLMKRQKMAMFFWQHGEEATVKAVIASILYRAMAREAKESNMVDDTSEELKKYSEQFGQ 679

Query: 1999 DAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQILLAELWH 2178
             A+++L++ ++ +    ++LL  EL +W N+ CL LAV    + F++H C Q+LL ++W
Sbjct: 680  LALDVLEKAFKQNEPMAMKLLTYELKNWSNSTCLKLAVSGGLRPFVSHSCTQMLLTDMWM 739

Query: 2179 GSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESITSTTSN 2358
            G LK+R  S ++++ +++ PP IL + +K K   +    S++      Y  + +++T
Sbjct: 740  GRLKMRKNSWLKIIISILLPPMILTLEFKSKAEMSHVPQSQDFQFTWNYSDQGLSNTKEA 799

Query: 2359 R-YRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXXFKREPQ-LNKFE 2532
            + Y   +GP+E+ +  L                                +  PQ L
Sbjct: 800  KDYDLERGPDEKLDEALH----------------------------LDLRNVPQSLPWTR 831

Query: 2533 RFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVEHIRK 2712
            R   FYS+P  KFW + +A+L FL   T  +L+E   +PS  EW+  IY  T ++E +R+
Sbjct: 832  RVYEFYSAPFVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQEWLVIIYIFTNAIEKVRE 891

Query: 2713 LMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFSNVLF 2892
            +  SE S+  +KVK++ ++++N+  + A+  F VG+G R      H+ GR++     + +
Sbjct: 892  ICISEPSKFTQKVKMWLSEYWNLMETVAIGLFAVGFGLRWGHPPLHTAGRLIYCIDIIFW 951

Query: 2893 YMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKDWHWL 3072
            + ++ ++ +V+   GPY+ M AKM  +M YI +++ + L++FGV R+A+  P  +   W
Sbjct: 952  FSRLLDFFAVNQHAGPYVTMIAKMAANMFYIVIIMAIVLLSFGVARKAILSPK-EPPSWR 1010

Query: 3073 LVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLMXXXXXXXXXXXXXXXXX 3252
            L R+I ++PY+M+YGEVYA EID C +E   C PG F+ P L
Sbjct: 1011 LARDIVFEPYWMMYGEVYASEIDVCSNE-TSCPPGSFLTPFLQAVYLFVQYIIMVNLLIA 1069

Query: 3253 XXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLYNLRRPDTK 3432
                 Y D    S ++W + RY+ +M YH  P+LPPPF + +H+   +  L     P  +
Sbjct: 1070 CFNNIYLDIKSISNKLWKYNRYRYIMTYHQKPWLPPPFILISHLCLLLRGLCCRPAPQDQ 1129

Query: 3433 RFRSEHSIKLSVTEDEMKRIQDFEEDCID 3519
                +  +KL +T+D++K++ DFEE C++
Sbjct: 1130 E-EGDMGLKLYLTKDDLKKLHDFEEQCVE 1157


>gi|28626251|gb|AAO49155.1| calcium-permeable store-operated channel
            TRPM3c [Homo sapiens]
          Length = 1566

 Score =  679 bits (1753), Expect = 0.0
 Identities = 396/1142 (34%), Positives = 638/1142 (55%), Gaps = 42/1142 (3%)
 Frame = +1

Query: 385  YVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTT 564
            YVR+S+D++P  +++LM K W LE P+L+I+VHGG+ NFEL+ +L ++F KG++KAA TT
Sbjct: 2    YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 565  GAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYY 744
            GAWI T G+++GV+RHV  AL +   +++ R +I TIGIAPWG+++ +E LI ++    Y
Sbjct: 62   GAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPY 119

Query: 745  DVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN---GRKVP 915
               S  ++  + +LN  HS+F+LADNGT G++GA++ LR+ LE HI+    N   G+ VP
Sbjct: 120  QTMSNPMS-KLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVP 178

Query: 916  VVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGE 1095
            VV  ++EGG + I+ + +Y+   P +P +VCDGSGRA+DI++F  +Y    G     + +
Sbjct: 179  VVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRD 238

Query: 1096 KLRNLIKMVFP--ETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQN 1269
            +L   I+  F    T  + +F  + EC+ + +L+ +FR G E  +D+D  IL+ +L+  N
Sbjct: 239  QLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGAN 298

Query: 1270 LPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVS 1449
                +QL+L L+WNRVD+A+S +F  G++W    LE+AM DAL  DRVDFV+ L+ENGVS
Sbjct: 299  ASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVS 358

Query: 1450 MKNFLSINRLENLYNMDDINSA---HSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNA 1620
            M  FL+I+RLE LYN     S    H VR+  +   ++ P   +++  IG V+E LMG A
Sbjct: 359  MHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKG--NLPPDYRISLIDIGLVIEYLMGGA 416

Query: 1621 FQLYYTSRSFKGKYDRY---KRINQSSYFHRKRKIV----QKELFKKKSDDQINDNEEED 1779
            ++  YT + F+  Y      KR         +  I     +K   K++ +  I+ ++ E
Sbjct: 417  YRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIPLRRGRKTTKKREEEVDIDLDDPEI 476

Query: 1780 FSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEE 1959
              F +PF++L++WAVL  R  MA   W HGE+AMAK L+A +L KA A  A +  +  +
Sbjct: 477  NHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDI 536

Query: 1960 AKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLA 2139
            ++ L  N+    + A+ELLDQ Y+ D    ++LL  EL +W N  CL LAV A  + F+A
Sbjct: 537  SQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIA 596

Query: 2140 HPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQL 2319
            H C Q+LL ++W G L++R  S ++V+  ++ PP+IL + +K K             + +
Sbjct: 597  HTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNK-------------DDM 643

Query: 2320 PYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXX 2499
            PY      S     +   K  EE ++   EK     ++T +  R N
Sbjct: 644  PY-----MSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQS 698

Query: 2500 FKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIY 2679
              R   L +  +   FY++PI KFW + +A++ +L     I+L++    PS  EWI   Y
Sbjct: 699  KHRLIPLGR--KIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISY 756

Query: 2680 TVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWG 2859
              TL +E +R+++ SE  ++ +KVKV+  +++N+    A+L F VG   RL      S G
Sbjct: 757  IFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDG 816

Query: 2860 RVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQAL 3039
            RV+   + + +Y+++ +   V+  LGPY+ M  KM+  M Y  +++LV LM+FGV RQA+
Sbjct: 817  RVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAI 876

Query: 3040 TEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEID-------------TCGDEGIR----- 3165
              PN ++  W L +NIFY PY+M+YGEV+A +ID              CG    R
Sbjct: 877  LFPN-EEPSWKLAKNIFYMPYWMIYGEVFADQIDRKQVYDSHTPKSAPCGQNETREDGKI 935

Query: 3166 -----CFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLM 3330
                 C  G +I P +M                      + +    S ++W FQRYQ +M
Sbjct: 936  IQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIM 995

Query: 3331 EYHDSPFLPPPFSIFAHVYHFIDYL-YNLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEE 3507
             +H+ P LPPP  IF+H+     +L    R+ ++     ++ +KL +T+DE+K++ DFEE
Sbjct: 996  TFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEE 1055

Query: 3508 DCIDTLTRIRKLKLNTK--EPLSVT-DLTELTCQRVHDLMQENFLLKSRVYDIETKIDHI 3678
             CI+   R +  + N+   E + VT +  E    R+ ++ +    +K+ +  ++ ++  +
Sbjct: 1056 QCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQL 1115

Query: 3679 SN 3684
             +
Sbjct: 1116 ED 1117


>gi|24653815|ref|NP_725447.1| CG30078-PB [Drosophila melanogaster]
 gi|21627149|gb|AAM68528.1| CG30078-PB [Drosophila melanogaster]
          Length = 1078

 Score =  678 bits (1750), Expect = 0.0
 Identities = 404/1055 (38%), Positives = 598/1055 (56%), Gaps = 32/1055 (3%)
 Frame = +1

Query: 133  WIENTFEKRECIRFAALPKDPERCGCGRPLSAHTPASTFFSTLPVHLLEKEQQTWTIANN 312
            WIE  F+KRECI+F   PKD  +C CG+    H       S  P  L       W    +
Sbjct: 15   WIETNFQKRECIKFIPCPKDDTKCCCGQAQITHQTIPGIESGSPGDL-------WLPTKH 67

Query: 313  TQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGM 492
            T+   TDA+GTI FQGGAH  KAQYVRLS+D+ P  ++ L  K W LE P+L+ITV GG
Sbjct: 68   TRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGK 127

Query: 493  SNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVT 672
            +NF+L+ +L +  RKG+LKAA+TTGAWI T G ++GV + V  AL   G   +   ++V+
Sbjct: 128  ANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEG--QQRTGRVVS 185

Query: 673  IGIAPWGVIKRKERLIRQNEHVYYDVHSLSV-NANVGILNDRHSYFLLADNGTVGRFGAD 849
            IGIAPWG+++R   L+  N  V    HS+S   + + +LN+RH+YFLL DNGT  ++GA+
Sbjct: 186  IGIAPWGIVERNHELLGHNREV--PCHSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAE 243

Query: 850  LHLRQNLENHIATFGCNG---RKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSG 1020
            L LR+ LE  I+    +       PVVC ++EGG ++I A+ +YVT  P +P +VCDGSG
Sbjct: 244  LILRRKLEKFISNLKLHPFTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSG 303

Query: 1021 RAADIISFAARYINSDGTFAAEVGEKLRNLIKMVFPET------DQEEMFRKITECVIRD 1182
            RAAD+++F  +Y  SDG     V E +R+ +     +T        E++++++ +C
Sbjct: 304  RAADLLAFVHKYA-SDGE-EQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNK 361

Query: 1183 DLLRIFRYGQEEE---EDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCLFSNGR 1353
            +L+ +FR  ++ E   +++D  IL+ + + Q+L P EQL+L L+WNRVD+A+S +F  G+
Sbjct: 362  NLITVFRIQEKPEGEAQELDQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQ 421

Query: 1354 KWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDDINSAHSVRNW 1533
            +W +  L++AM  AL  DR+DFV+ LLENGVSMK FL+I RLE LYN      A+++
Sbjct: 422  EWPNGALDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKH-GPANTLGYI 480

Query: 1534 MENFDSMDPHTYL-TIPMIGQVVEKLMGNAFQLYYTSRSFKGKYDRYKRINQSSYFHRKR 1710
            + +     P  Y+ T+  IG V+ KLMG A++ YYT R F+  Y   K +N  +   RK
Sbjct: 481  LRDVRPHIPKGYIYTLHDIGLVINKLMGGAYRSYYTRRKFRPIYA--KVMNSYANACRKS 538

Query: 1711 KIVQKELFKKKSDDQINDN----EEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDA 1878
               Q + +   +   +         E   F +PFN+LLIWAVLT R  MA  MW HGE+A
Sbjct: 539  STYQYQRYAGANSLSLVTGLLPFTSEMALFEFPFNELLIWAVLTKRQQMALLMWTHGEEA 598

Query: 1879 MAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRL 2058
            +AK L++ +LYKA A  A ++ LD E  + L   A +      +LLD  YR D ++  RL
Sbjct: 599  LAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRL 658

Query: 2059 LRMELPHWGNNNCLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICP 2238
            L  EL  W N +CLSLAV AN +  LAHPC Q++LA+LW G L+ R  +N +V+  L  P
Sbjct: 659  LTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMP 718

Query: 2239 PAILFMAYKPKHSKTARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEKGS 2418
              I  + +K          S+E  +Q+P   E      +     S   +   E LL   +
Sbjct: 719  FYIRQLDFK----------SKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAEALL-ADT 767

Query: 2419 YTKKVTIISSRKNXXXXXXXXXXXXXXF--------KREPQLNKFERFRAFYSSPITKFW 2574
            Y+ + T +                   F        K+   L   ++F  FY++PITKFW
Sbjct: 768  YSVRDTKVHENGKVSLTDSDTAQFREFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFW 827

Query: 2575 SWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVK 2754
            +  IA++ FL   +  +L++    P   EW +  Y  TL  E +R++++SE   I  K
Sbjct: 828  ADSIAYMFFLIMFSFTVLVKMEQMPRWQEWYSIAYITTLGFEKVREIISSEPVAITHKFS 887

Query: 2755 VFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSW---GRVLLSFSNVLFYMKIFEYLSVH 2925
            V+    +N    AA++ F++G  FR    +R +    GRV+    ++ +Y++I   L V+
Sbjct: 888  VWAWNMWNPCDGAAIILFVIGLAFR----FRENTMDIGRVIYCVDSIYWYLRILNILGVN 943

Query: 2926 PLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYF 3105
              LGP + M  KMV +M Y  VLL V LM+FGV+RQA+  PN K   W L++ + ++PYF
Sbjct: 944  KYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPN-KQPTWSLIKEVTFQPYF 1002

Query: 3106 MLYGEVYAGEID-TCGDEGIR--CFPGYFIPPLLM 3201
            MLYGEV+AG+ID  CG++  +  C  G+++ P+ M
Sbjct: 1003 MLYGEVFAGDIDPPCGEDPSQPGCVTGHWVTPITM 1037


>gi|37790764|gb|AAR03488.1| transient receptor potential cation
            channel subfamily M member 6 variant b [Homo sapiens]
          Length = 2017

 Score =  678 bits (1750), Expect = 0.0
 Identities = 403/1254 (32%), Positives = 681/1254 (54%), Gaps = 52/1254 (4%)
 Frame = +1

Query: 109  LTEKLSPPWIENTFEKRECIRFAALPKDPERCG-------------CGRPLSAHTPASTF 249
            +  K    WI+  F+KREC       K+P RC              CGR +  H  A
Sbjct: 3    ILSKSQKSWIKGVFDKRECSTIIPSSKNPHRCTPVCQVCQNLIRCYCGRLIGDH--AGID 60

Query: 250  FSTLPVHLLEKEQQTWTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMY 429
            +S        KE + W++  +T  S TD FGTI FQ G H H A+Y+R SYD++   +++
Sbjct: 61   YSWTISAAKGKESEQWSVEKHTTKSPTDTFGTINFQDGEHTHHAKYIRTSYDTKLDHLLH 120

Query: 430  LMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVR 609
            LM K W +E P+LVI+VHGG+ NF +  +   +F +G++KAA+TTGAWIIT G+++GV +
Sbjct: 121  LMLKEWKMELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETTGAWIITEGINTGVSK 180

Query: 610  HVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILN 789
            HV  AL     S+    +I T+GI PWGVI+ +  LI ++    Y      ++  +  LN
Sbjct: 181  HVGDALKSH--SSHSLRKIWTVGIPPWGVIENQRDLIGKDVVCLYQTLDNPLS-KLTTLN 237

Query: 790  DRHSYFLLADNGTVGRFGADLHLRQNLENHIAT--FGCNGRK-VPVVCTLLEGGISSINA 960
              HS+F+L+D+GTVG++G ++ LR+NLE +++     C  R+ VPVV  ++EGG + I +
Sbjct: 238  SMHSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQGVPVVGLVVEGGPNVILS 297

Query: 961  IHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMVFPET-- 1134
            + +  T+K   P +VC+G+GRAAD+++F  +++  +G    +V E++  +I+  F  +
Sbjct: 298  VWE--TVKDKDPVVVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEIICMIQNTFNFSLK 355

Query: 1135 DQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNR 1314
              + +F+ + EC++  D + IF    EE++D+D  IL+ +L+  NL   EQL L ++W+R
Sbjct: 356  QSKHLFQILMECMVHRDCITIFDADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDR 415

Query: 1315 VDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYN 1494
            VD+AK  +    + W  D LE+AM+DAL  DRVDFV+ L+E GV++  FL+I RLE LYN
Sbjct: 416  VDIAKKHILIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYN 475

Query: 1495 MDDINSAHSVRNWMENFDSMDPHTYL-----TIPMIGQVVEKLMGNAFQLYYTSRSFKGK 1659
                 +   + + +++   +  HT L     T+  IG VVE L+G A++  YT + F+
Sbjct: 476  TKQGPTNTLLHHLVQD---VKQHTLLSGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRAL 532

Query: 1660 YD----RYKRINQSS---------------------YFHRKRKIVQKELFKKKSDDQIND 1764
            Y+    +YK    SS                     Y  +++ IV  +  KK  +  ++D
Sbjct: 533  YNNLYRKYKHQRHSSGNRNESAESTLHSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSD 592

Query: 1765 NEEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEY 1944
            + E    F YP+NDLL+WAVL  R  MA   W HGE+A  K ++A  LY+A A  A++ +
Sbjct: 593  DPEST-GFLYPYNDLLVWAVLMKRQKMAMFFWQHGEEATVKAVIACILYRAMAHEAKESH 651

Query: 1945 LDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANT 2124
            +  + ++ L + + +  + A++LL++ ++ +    + LL  EL +W N+ CL LAV
Sbjct: 652  MVDDASEELKNYSKQFGQLALDLLEKAFKQNERMAMTLLTYELRNWSNSTCLKLAVSGGL 711

Query: 2125 KTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEE 2304
            + F++H C Q+LL ++W G LK+R  S ++++ ++I PP IL + +K K   +    S++
Sbjct: 712  RPFVSHTCTQMLLTDMWMGRLKMRKNSWLKIIISIILPPTILTLEFKSKAEMSHVPQSQD 771

Query: 2305 TPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXX 2484
                  Y  ++ +S        SK     KE  LE+G   K    +   ++
Sbjct: 772  FQFMWYYSDQNASS--------SKESASVKEYDLERGHDEK----LDENQHFGLESG--- 816

Query: 2485 XXXXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEW 2664
                       L    +   FYS+PI KFW + +A+L FL   T  +L+E   +PS  EW
Sbjct: 817  --------HQHLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQEW 868

Query: 2665 ITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMY 2844
            +  IY  T ++E +R++  SE  +  +KVKV+ ++++N+  + A+  F  G+  R
Sbjct: 869  LVSIYIFTNAIEVVREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGFVLRWGDPP 928

Query: 2845 RHSWGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGV 3024
             H+ GR++     + ++ ++ ++ +V+   GPY+ M AKM  +M YI +++ + L++FGV
Sbjct: 929  FHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLSFGV 988

Query: 3025 NRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLMX 3204
             R+A+  P  +   W L R+I ++PY+M+YGEVYAGEID C  +   C PG F+ P L
Sbjct: 989  ARKAILSPK-EPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQP-SCPPGSFLTPFLQA 1046

Query: 3205 XXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHV 3384
                                 Y D    S  +W + RY+ +M YH+ P+LPPP  + +HV
Sbjct: 1047 VYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWLPPPLILLSHV 1106

Query: 3385 YHFIDYLYNLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTL--TRIRKLKLNTK 3558
               +  L   R P  +    +  +KL ++++++K++ DFEE C++     ++  +  + +
Sbjct: 1107 GLLLRRLCCHRAPHDQE-EGDVGLKLYLSKEDLKKLHDFEEQCVEKYFHEKMEDVNCSCE 1165

Query: 3559 EPLSVTD--LTELTCQRVHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILK 3714
            E + VT   +TE+  Q + ++ ++   +K  +  +++++ H+ + S   V  LK
Sbjct: 1166 ERIRVTSERVTEMYFQ-LKEMNEKVSFIKDSLLSLDSQVGHLQDLSALTVDTLK 1218


>gi|18921093|ref|NP_060132.3| transient receptor potential cation
            channel, subfamily M, member 6; hypomagnesemia, secondary
            hypocalcemia [Homo sapiens]
 gi|18860924|gb|AAK31202.2| channel-kinase 2 [Homo sapiens]
 gi|20386048|gb|AAM21562.1| LTRPC6 channel kinase 2 [Homo sapiens]
 gi|37790762|gb|AAR03487.1| transient receptor potential cation
            channel subfamily M member 6 variant a [Homo sapiens]
          Length = 2022

 Score =  677 bits (1748), Expect = 0.0
 Identities = 402/1246 (32%), Positives = 679/1246 (54%), Gaps = 52/1246 (4%)
 Frame = +1

Query: 133  WIENTFEKRECIRFAALPKDPERCG-------------CGRPLSAHTPASTFFSTLPVHL 273
            WI+  F+KREC       K+P RC              CGR +  H  A   +S
Sbjct: 16   WIKGVFDKRECSTIIPSSKNPHRCTPVCQVCQNLIRCYCGRLIGDH--AGIDYSWTISAA 73

Query: 274  LEKEQQTWTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLMEKVWGL 453
              KE + W++  +T  S TD FGTI FQ G H H A+Y+R SYD++   +++LM K W +
Sbjct: 74   KGKESEQWSVEKHTTKSPTDTFGTINFQDGEHTHHAKYIRTSYDTKLDHLLHLMLKEWKM 133

Query: 454  EAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVAKALDE 633
            E P+LVI+VHGG+ NF +  +   +F +G++KAA+TTGAWIIT G+++GV +HV  AL
Sbjct: 134  ELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETTGAWIITEGINTGVSKHVGDALKS 193

Query: 634  AGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRHSYFLL 813
               S+    +I T+GI PWGVI+ +  LI ++    Y      ++  +  LN  HS+F+L
Sbjct: 194  H--SSHSLRKIWTVGIPPWGVIENQRDLIGKDVVCLYQTLDNPLS-KLTTLNSMHSHFIL 250

Query: 814  ADNGTVGRFGADLHLRQNLENHIAT--FGCNGRK-VPVVCTLLEGGISSINAIHDYVTMK 984
            +D+GTVG++G ++ LR+NLE +++     C  R+ VPVV  ++EGG + I ++ +  T+K
Sbjct: 251  SDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQGVPVVGLVVEGGPNVILSVWE--TVK 308

Query: 985  PDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMVFPET--DQEEMFRK 1158
               P +VC+G+GRAAD+++F  +++  +G    +V E++  +I+  F  +    + +F+
Sbjct: 309  DKDPVVVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEIICMIQNTFNFSLKQSKHLFQI 368

Query: 1159 ITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCL 1338
            + EC++  D + IF    EE++D+D  IL+ +L+  NL   EQL L ++W+RVD+AK  +
Sbjct: 369  LMECMVHRDCITIFDADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDRVDIAKKHI 428

Query: 1339 FSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDDINSAH 1518
                + W  D LE+AM+DAL  DRVDFV+ L+E GV++  FL+I RLE LYN     +
Sbjct: 429  LIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNT 488

Query: 1519 SVRNWMENFDSMDPHTYL-----TIPMIGQVVEKLMGNAFQLYYTSRSFKGKYD----RY 1671
             + + +++   +  HT L     T+  IG VVE L+G A++  YT + F+  Y+    +Y
Sbjct: 489  LLHHLVQD---VKQHTLLSGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNNLYRKY 545

Query: 1672 KRINQSS---------------------YFHRKRKIVQKELFKKKSDDQINDNEEEDFSF 1788
            K    SS                     Y  +++ IV  +  KK  +  ++D+ E    F
Sbjct: 546  KHQRHSSGNRNESAESTLHSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSDDPEST-GF 604

Query: 1789 AYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKR 1968
             YP+NDLL+WAVL  R  MA   W HGE+A  K ++A  LY+A A  A++ ++  + ++
Sbjct: 605  LYPYNDLLVWAVLMKRQKMAMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDDASEE 664

Query: 1969 LFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPC 2148
            L + + +  + A++LL++ ++ +    + LL  EL +W N+ CL LAV    + F++H C
Sbjct: 665  LKNYSKQFGQLALDLLEKAFKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTC 724

Query: 2149 CQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYP 2328
             Q+LL ++W G LK+R  S ++++ ++I PP IL + +K K   +    S++      Y
Sbjct: 725  TQMLLTDMWMGRLKMRKNSWLKIIISIILPPTILTLEFKSKAEMSHVPQSQDFQFMWYYS 784

Query: 2329 RESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXXFKR 2508
             ++ +S        SK     KE  LE+G   K    +   ++
Sbjct: 785  DQNASS--------SKESASVKEYDLERGHDEK----LDENQHFGLESG----------- 821

Query: 2509 EPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVT 2688
               L    +   FYS+PI KFW + +A+L FL   T  +L+E   +PS  EW+  IY  T
Sbjct: 822  HQHLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIFT 881

Query: 2689 LSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVL 2868
             ++E +R++  SE  +  +KVKV+ ++++N+  + A+  F  G+  R      H+ GR++
Sbjct: 882  NAIEVVREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGFVLRWGDPPFHTAGRLI 941

Query: 2869 LSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEP 3048
                 + ++ ++ ++ +V+   GPY+ M AKM  +M YI +++ + L++FGV R+A+  P
Sbjct: 942  YCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLSFGVARKAILSP 1001

Query: 3049 NVKDWHWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLMXXXXXXXXX 3228
              +   W L R+I ++PY+M+YGEVYAGEID C  +   C PG F+ P L
Sbjct: 1002 K-EPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQP-SCPPGSFLTPFLQAVYLFVQYI 1059

Query: 3229 XXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLY 3408
                         Y D    S  +W + RY+ +M YH+ P+LPPP  + +HV   +  L
Sbjct: 1060 IMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRLC 1119

Query: 3409 NLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTL--TRIRKLKLNTKEPLSVTD- 3579
              R P  +    +  +KL ++++++K++ DFEE C++     ++  +  + +E + VT
Sbjct: 1120 CHRAPHDQE-EGDVGLKLYLSKEDLKKLHDFEEQCVEKYFHEKMEDVNCSCEERIRVTSE 1178

Query: 3580 -LTELTCQRVHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILK 3714
             +TE+  Q + ++ ++   +K  +  +++++ H+ + S   V  LK
Sbjct: 1179 RVTEMYFQ-LKEMNEKVSFIKDSLLSLDSQVGHLQDLSALTVDTLK 1223


>gi|37790766|gb|AAR03489.1| transient receptor potential cation
            channel subfamily M member 6 variant c [Homo sapiens]
          Length = 2017

 Score =  677 bits (1748), Expect = 0.0
 Identities = 402/1246 (32%), Positives = 679/1246 (54%), Gaps = 52/1246 (4%)
 Frame = +1

Query: 133  WIENTFEKRECIRFAALPKDPERCG-------------CGRPLSAHTPASTFFSTLPVHL 273
            WI+  F+KREC       K+P RC              CGR +  H  A   +S
Sbjct: 11   WIKGVFDKRECSTIIPSSKNPHRCTPVCQVCQNLIRCYCGRLIGDH--AGIDYSWTISAA 68

Query: 274  LEKEQQTWTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLMEKVWGL 453
              KE + W++  +T  S TD FGTI FQ G H H A+Y+R SYD++   +++LM K W +
Sbjct: 69   KGKESEQWSVEKHTTKSPTDTFGTINFQDGEHTHHAKYIRTSYDTKLDHLLHLMLKEWKM 128

Query: 454  EAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVAKALDE 633
            E P+LVI+VHGG+ NF +  +   +F +G++KAA+TTGAWIIT G+++GV +HV  AL
Sbjct: 129  ELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETTGAWIITEGINTGVSKHVGDALKS 188

Query: 634  AGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRHSYFLL 813
               S+    +I T+GI PWGVI+ +  LI ++    Y      ++  +  LN  HS+F+L
Sbjct: 189  H--SSHSLRKIWTVGIPPWGVIENQRDLIGKDVVCLYQTLDNPLS-KLTTLNSMHSHFIL 245

Query: 814  ADNGTVGRFGADLHLRQNLENHIAT--FGCNGRK-VPVVCTLLEGGISSINAIHDYVTMK 984
            +D+GTVG++G ++ LR+NLE +++     C  R+ VPVV  ++EGG + I ++ +  T+K
Sbjct: 246  SDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQGVPVVGLVVEGGPNVILSVWE--TVK 303

Query: 985  PDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMVFPET--DQEEMFRK 1158
               P +VC+G+GRAAD+++F  +++  +G    +V E++  +I+  F  +    + +F+
Sbjct: 304  DKDPVVVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEIICMIQNTFNFSLKQSKHLFQI 363

Query: 1159 ITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCL 1338
            + EC++  D + IF    EE++D+D  IL+ +L+  NL   EQL L ++W+RVD+AK  +
Sbjct: 364  LMECMVHRDCITIFDADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDRVDIAKKHI 423

Query: 1339 FSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDDINSAH 1518
                + W  D LE+AM+DAL  DRVDFV+ L+E GV++  FL+I RLE LYN     +
Sbjct: 424  LIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNT 483

Query: 1519 SVRNWMENFDSMDPHTYL-----TIPMIGQVVEKLMGNAFQLYYTSRSFKGKYD----RY 1671
             + + +++   +  HT L     T+  IG VVE L+G A++  YT + F+  Y+    +Y
Sbjct: 484  LLHHLVQD---VKQHTLLSGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNNLYRKY 540

Query: 1672 KRINQSS---------------------YFHRKRKIVQKELFKKKSDDQINDNEEEDFSF 1788
            K    SS                     Y  +++ IV  +  KK  +  ++D+ E    F
Sbjct: 541  KHQRHSSGNRNESAESTLHSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSDDPEST-GF 599

Query: 1789 AYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKR 1968
             YP+NDLL+WAVL  R  MA   W HGE+A  K ++A  LY+A A  A++ ++  + ++
Sbjct: 600  LYPYNDLLVWAVLMKRQKMAMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDDASEE 659

Query: 1969 LFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPC 2148
            L + + +  + A++LL++ ++ +    + LL  EL +W N+ CL LAV    + F++H C
Sbjct: 660  LKNYSKQFGQLALDLLEKAFKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTC 719

Query: 2149 CQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYP 2328
             Q+LL ++W G LK+R  S ++++ ++I PP IL + +K K   +    S++      Y
Sbjct: 720  TQMLLTDMWMGRLKMRKNSWLKIIISIILPPTILTLEFKSKAEMSHVPQSQDFQFMWYYS 779

Query: 2329 RESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXXFKR 2508
             ++ +S        SK     KE  LE+G   K    +   ++
Sbjct: 780  DQNASS--------SKESASVKEYDLERGHDEK----LDENQHFGLESG----------- 816

Query: 2509 EPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVT 2688
               L    +   FYS+PI KFW + +A+L FL   T  +L+E   +PS  EW+  IY  T
Sbjct: 817  HQHLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIFT 876

Query: 2689 LSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVL 2868
             ++E +R++  SE  +  +KVKV+ ++++N+  + A+  F  G+  R      H+ GR++
Sbjct: 877  NAIEVVREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGFVLRWGDPPFHTAGRLI 936

Query: 2869 LSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEP 3048
                 + ++ ++ ++ +V+   GPY+ M AKM  +M YI +++ + L++FGV R+A+  P
Sbjct: 937  YCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLSFGVARKAILSP 996

Query: 3049 NVKDWHWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLMXXXXXXXXX 3228
              +   W L R+I ++PY+M+YGEVYAGEID C  +   C PG F+ P L
Sbjct: 997  K-EPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQP-SCPPGSFLTPFLQAVYLFVQYI 1054

Query: 3229 XXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLY 3408
                         Y D    S  +W + RY+ +M YH+ P+LPPP  + +HV   +  L
Sbjct: 1055 IMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRLC 1114

Query: 3409 NLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTL--TRIRKLKLNTKEPLSVTD- 3579
              R P  +    +  +KL ++++++K++ DFEE C++     ++  +  + +E + VT
Sbjct: 1115 CHRAPHDQE-EGDVGLKLYLSKEDLKKLHDFEEQCVEKYFHEKMEDVNCSCEERIRVTSE 1173

Query: 3580 -LTELTCQRVHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILK 3714
             +TE+  Q + ++ ++   +K  +  +++++ H+ + S   V  LK
Sbjct: 1174 RVTEMYFQ-LKEMNEKVSFIKDSLLSLDSQVGHLQDLSALTVDTLK 1218


>gi|37790768|gb|AAR03490.1| truncated transient receptor potential
            cation channel subfamily M member 6 variant a [Homo
            sapiens]
          Length = 1943

 Score =  677 bits (1748), Expect = 0.0
 Identities = 402/1246 (32%), Positives = 679/1246 (54%), Gaps = 52/1246 (4%)
 Frame = +1

Query: 133  WIENTFEKRECIRFAALPKDPERCG-------------CGRPLSAHTPASTFFSTLPVHL 273
            WI+  F+KREC       K+P RC              CGR +  H  A   +S
Sbjct: 16   WIKGVFDKRECSTIIPSSKNPHRCTPVCQVCQNLIRCYCGRLIGDH--AGIDYSWTISAA 73

Query: 274  LEKEQQTWTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLMEKVWGL 453
              KE + W++  +T  S TD FGTI FQ G H H A+Y+R SYD++   +++LM K W +
Sbjct: 74   KGKESEQWSVEKHTTKSPTDTFGTINFQDGEHTHHAKYIRTSYDTKLDHLLHLMLKEWKM 133

Query: 454  EAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVAKALDE 633
            E P+LVI+VHGG+ NF +  +   +F +G++KAA+TTGAWIIT G+++GV +HV  AL
Sbjct: 134  ELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETTGAWIITEGINTGVSKHVGDALKS 193

Query: 634  AGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRHSYFLL 813
               S+    +I T+GI PWGVI+ +  LI ++    Y      ++  +  LN  HS+F+L
Sbjct: 194  H--SSHSLRKIWTVGIPPWGVIENQRDLIGKDVVCLYQTLDNPLS-KLTTLNSMHSHFIL 250

Query: 814  ADNGTVGRFGADLHLRQNLENHIAT--FGCNGRK-VPVVCTLLEGGISSINAIHDYVTMK 984
            +D+GTVG++G ++ LR+NLE +++     C  R+ VPVV  ++EGG + I ++ +  T+K
Sbjct: 251  SDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQGVPVVGLVVEGGPNVILSVWE--TVK 308

Query: 985  PDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMVFPET--DQEEMFRK 1158
               P +VC+G+GRAAD+++F  +++  +G    +V E++  +I+  F  +    + +F+
Sbjct: 309  DKDPVVVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEIICMIQNTFNFSLKQSKHLFQI 368

Query: 1159 ITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCL 1338
            + EC++  D + IF    EE++D+D  IL+ +L+  NL   EQL L ++W+RVD+AK  +
Sbjct: 369  LMECMVHRDCITIFDADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDRVDIAKKHI 428

Query: 1339 FSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDDINSAH 1518
                + W  D LE+AM+DAL  DRVDFV+ L+E GV++  FL+I RLE LYN     +
Sbjct: 429  LIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNT 488

Query: 1519 SVRNWMENFDSMDPHTYL-----TIPMIGQVVEKLMGNAFQLYYTSRSFKGKYD----RY 1671
             + + +++   +  HT L     T+  IG VVE L+G A++  YT + F+  Y+    +Y
Sbjct: 489  LLHHLVQD---VKQHTLLSGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNNLYRKY 545

Query: 1672 KRINQSS---------------------YFHRKRKIVQKELFKKKSDDQINDNEEEDFSF 1788
            K    SS                     Y  +++ IV  +  KK  +  ++D+ E    F
Sbjct: 546  KHQRHSSGNRNESAESTLHSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSDDPEST-GF 604

Query: 1789 AYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKR 1968
             YP+NDLL+WAVL  R  MA   W HGE+A  K ++A  LY+A A  A++ ++  + ++
Sbjct: 605  LYPYNDLLVWAVLMKRQKMAMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDDASEE 664

Query: 1969 LFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPC 2148
            L + + +  + A++LL++ ++ +    + LL  EL +W N+ CL LAV    + F++H C
Sbjct: 665  LKNYSKQFGQLALDLLEKAFKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTC 724

Query: 2149 CQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYP 2328
             Q+LL ++W G LK+R  S ++++ ++I PP IL + +K K   +    S++      Y
Sbjct: 725  TQMLLTDMWMGRLKMRKNSWLKIIISIILPPTILTLEFKSKAEMSHVPQSQDFQFMWYYS 784

Query: 2329 RESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXXFKR 2508
             ++ +S        SK     KE  LE+G   K    +   ++
Sbjct: 785  DQNASS--------SKESASVKEYDLERGHDEK----LDENQHFGLESG----------- 821

Query: 2509 EPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVT 2688
               L    +   FYS+PI KFW + +A+L FL   T  +L+E   +PS  EW+  IY  T
Sbjct: 822  HQHLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIFT 881

Query: 2689 LSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVL 2868
             ++E +R++  SE  +  +KVKV+ ++++N+  + A+  F  G+  R      H+ GR++
Sbjct: 882  NAIEVVREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGFVLRWGDPPFHTAGRLI 941

Query: 2869 LSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEP 3048
                 + ++ ++ ++ +V+   GPY+ M AKM  +M YI +++ + L++FGV R+A+  P
Sbjct: 942  YCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLSFGVARKAILSP 1001

Query: 3049 NVKDWHWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCFPGYFIPPLLMXXXXXXXXX 3228
              +   W L R+I ++PY+M+YGEVYAGEID C  +   C PG F+ P L
Sbjct: 1002 K-EPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQP-SCPPGSFLTPFLQAVYLFVQYI 1059

Query: 3229 XXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYLY 3408
                         Y D    S  +W + RY+ +M YH+ P+LPPP  + +HV   +  L
Sbjct: 1060 IMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRLC 1119

Query: 3409 NLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTL--TRIRKLKLNTKEPLSVTD- 3579
              R P  +    +  +KL ++++++K++ DFEE C++     ++  +  + +E + VT
Sbjct: 1120 CHRAPHDQE-EGDVGLKLYLSKEDLKKLHDFEEQCVEKYFHEKMEDVNCSCEERIRVTSE 1178

Query: 3580 -LTELTCQRVHDLMQENFLLKSRVYDIETKIDHISNSSDEVVQILK 3714
             +TE+  Q + ++ ++   +K  +  +++++ H+ + S   V  LK
Sbjct: 1179 RVTEMYFQ-LKEMNEKVSFIKDSLLSLDSQVGHLQDLSALTVDTLK 1223


>gi|45935366|ref|NP_996830.1| transient receptor potential cation
            channel, subfamily M, member 3 isoform g; melastatin 2;
            long transient receptor potential channel 3 [Homo
            sapiens]
          Length = 1569

 Score =  677 bits (1747), Expect = 0.0
 Identities = 394/1148 (34%), Positives = 637/1148 (55%), Gaps = 48/1148 (4%)
 Frame = +1

Query: 385  YVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTT 564
            YVR+S+D++P  +++LM K W LE P+L+I+VHGG+ NFEL+ +L ++F KG++KAA TT
Sbjct: 2    YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 565  GAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYY 744
            GAWI T G+++GV+RHV  AL +   +++ R +I TIGIAPWG+++ +E LI ++    Y
Sbjct: 62   GAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPY 119

Query: 745  DVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN-------- 900
               S +  + + +LN  HS+F+LADNGT G++GA++ LR+ LE HI+    N
Sbjct: 120  QTMS-NPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPFFS 178

Query: 901  --------------------GRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSG 1020
                                G+ VPVV  ++EGG + I+ + +Y+   P +P +VCDGSG
Sbjct: 179  LDSRLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSG 238

Query: 1021 RAADIISFAARYINSDGTFAAEVGEKLRNLIKMVF--PETDQEEMFRKITECVIRDDLLR 1194
            RA+DI++F  +Y    G     + ++L   I+  F    T  + +F  + EC+ + +L+
Sbjct: 239  RASDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELIT 298

Query: 1195 IFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVL 1374
            +FR G E  +D+D  IL+ +L+  N    +QL+L L+WNRVD+A+S +F  G++W    L
Sbjct: 299  VFRMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSL 358

Query: 1375 EKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDDINS---AHSVRNWMENF 1545
            E+AM DAL  DRVDFV+ L+ENGVSM  FL+I+RLE LYN     S    H VR+  +
Sbjct: 359  EQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKG- 417

Query: 1546 DSMDPHTYLTIPMIGQVVEKLMGNAFQLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQK 1725
             ++ P   +++  IG V+E LMG A++  YT + F+  Y       +     R+ +   K
Sbjct: 418  -NLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDIPLRRGRKTTK 476

Query: 1726 ELFKKKSDDQINDNEEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIR 1905
               K++ +  I+ ++ E   F +PF++L++WAVL  R  MA   W HGE+AMAK L+A +
Sbjct: 477  ---KREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACK 533

Query: 1906 LYKATAKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWG 2085
            L KA A  A +  +  + ++ L  N+    + A+ELLDQ Y+ D    ++LL  EL +W
Sbjct: 534  LCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWS 593

Query: 2086 NNNCLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYK 2265
            N  CL LAV A  + F+AH C Q+LL ++W G L++R  S ++V+  ++ PP+IL + +K
Sbjct: 594  NATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFK 653

Query: 2266 PKHSKTARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIIS 2445
             K             + +PY      S     +   K  EE ++   EK     ++T +
Sbjct: 654  NK-------------DDMPY-----MSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAML 695

Query: 2446 SRKNXXXXXXXXXXXXXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCIL 2625
             R N                R   L +  +   FY++PI KFW + +A++ +L     I+
Sbjct: 696  GRNNGESSRKKDEEEVQSKHRLIPLGR--KIYEFYNAPIVKFWFYTLAYIGYLMLFNYIV 753

Query: 2626 LLETSLKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLF 2805
            L++    PS  EWI   Y  TL +E +R+++ SE  ++ +KVKV+  +++N+    A+L
Sbjct: 754  LVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILL 813

Query: 2806 FLVGYGFRLVPMYRHSWGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYI 2985
            F VG   RL      S GRV+   + + +Y+++ +   V+  LGPY+ M  KM+  M Y
Sbjct: 814  FSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYF 873

Query: 2986 CVLLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEID-TCGDEGI 3162
             +++LV LM+FGV RQA+  PN ++  W L +NIFY PY+M+YGEV+A +ID  CG
Sbjct: 874  VIIMLVVLMSFGVARQAILFPN-EEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNET 932

Query: 3163 R----------CFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQ 3312
            R          C  G +I P +M                      + +    S ++W FQ
Sbjct: 933  REDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQ 992

Query: 3313 RYQQLMEYHDSPFLPPPFSIFAHVYHFIDYL-YNLRRPDTKRFRSEHSIKLSVTEDEMKR 3489
            RYQ +M +H+ P LPPP  IF+H+     +L    R+ ++     ++ +KL +T+DE+K+
Sbjct: 993  RYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKK 1052

Query: 3490 IQDFEEDCIDTLTRIRKLKLNTK--EPLSVT-DLTELTCQRVHDLMQENFLLKSRVYDIE 3660
            + DFEE CI+   R +  + N+   E + VT +  E    R+ ++ +    +K+ +  ++
Sbjct: 1053 VHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVD 1112

Query: 3661 TKIDHISN 3684
             ++  + +
Sbjct: 1113 IRLAQLED 1120


>gi|27597207|dbj|BAC55103.1| hypothetical protein [Homo sapiens]
          Length = 1569

 Score =  677 bits (1747), Expect = 0.0
 Identities = 394/1148 (34%), Positives = 637/1148 (55%), Gaps = 48/1148 (4%)
 Frame = +1

Query: 385  YVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTT 564
            YVR+S+D++P  +++LM K W LE P+L+I+VHGG+ NFEL+ +L ++F KG++KAA TT
Sbjct: 2    YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 565  GAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYY 744
            GAWI T G+++GV+RHV  AL +   +++ R +I TIGIAPWG+++ +E LI ++    Y
Sbjct: 62   GAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPY 119

Query: 745  DVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN-------- 900
               S +  + + +LN  HS+F+LADNGT G++GA++ LR+ LE HI+    N
Sbjct: 120  QTMS-NPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPFFS 178

Query: 901  --------------------GRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSG 1020
                                G+ VPVV  ++EGG + I+ + +Y+   P +P +VCDGSG
Sbjct: 179  LDSHLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSG 238

Query: 1021 RAADIISFAARYINSDGTFAAEVGEKLRNLIKMVF--PETDQEEMFRKITECVIRDDLLR 1194
            RA+DI++F  +Y    G     + ++L   I+  F    T  + +F  + EC+ + +L+
Sbjct: 239  RASDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELIT 298

Query: 1195 IFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVL 1374
            +FR G E  +D+D  IL+ +L+  N    +QL+L L+WNRVD+A+S +F  G++W    L
Sbjct: 299  VFRMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSL 358

Query: 1375 EKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDDINS---AHSVRNWMENF 1545
            E+AM DAL  DRVDFV+ L+ENGVSM  FL+I+RLE LYN     S    H VR+  +
Sbjct: 359  EQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKG- 417

Query: 1546 DSMDPHTYLTIPMIGQVVEKLMGNAFQLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQK 1725
             ++ P   +++  IG V+E LMG A++  YT + F+  Y       +     R+ +   K
Sbjct: 418  -NLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDIPLRRGRKTTK 476

Query: 1726 ELFKKKSDDQINDNEEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIR 1905
               K++ +  I+ ++ E   F +PF++L++WAVL  R  MA   W HGE+AMAK L+A +
Sbjct: 477  ---KREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACK 533

Query: 1906 LYKATAKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWG 2085
            L KA A  A +  +  + ++ L  N+    + A+ELLDQ Y+ D    ++LL  EL +W
Sbjct: 534  LCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWS 593

Query: 2086 NNNCLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYK 2265
            N  CL LAV A  + F+AH C Q+LL ++W G L++R  S ++V+  ++ PP+IL + +K
Sbjct: 594  NATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFK 653

Query: 2266 PKHSKTARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIIS 2445
             K             + +PY      S     +   K  EE ++   EK     ++T +
Sbjct: 654  NK-------------DDMPY-----MSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAML 695

Query: 2446 SRKNXXXXXXXXXXXXXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCIL 2625
             R N                R   L +  +   FY++PI KFW + +A++ +L     I+
Sbjct: 696  GRNNGESSRKKDEEEVQSKHRLIPLGR--KIYEFYNAPIVKFWFYTLAYIGYLMLFNYIV 753

Query: 2626 LLETSLKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLF 2805
            L++    PS  EWI   Y  TL +E +R+++ SE  ++ +KVKV+  +++N+    A+L
Sbjct: 754  LVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILL 813

Query: 2806 FLVGYGFRLVPMYRHSWGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYI 2985
            F VG   RL      S GRV+   + + +Y+++ +   V+  LGPY+ M  KM+  M Y
Sbjct: 814  FSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYF 873

Query: 2986 CVLLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEID-TCGDEGI 3162
             +++LV LM+FGV RQA+  PN ++  W L +NIFY PY+M+YGEV+A +ID  CG
Sbjct: 874  VIIMLVVLMSFGVARQAILFPN-EEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNET 932

Query: 3163 R----------CFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQ 3312
            R          C  G +I P +M                      + +    S ++W FQ
Sbjct: 933  REDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQ 992

Query: 3313 RYQQLMEYHDSPFLPPPFSIFAHVYHFIDYL-YNLRRPDTKRFRSEHSIKLSVTEDEMKR 3489
            RYQ +M +H+ P LPPP  IF+H+     +L    R+ ++     ++ +KL +T+DE+K+
Sbjct: 993  RYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKK 1052

Query: 3490 IQDFEEDCIDTLTRIRKLKLNTK--EPLSVT-DLTELTCQRVHDLMQENFLLKSRVYDIE 3660
            + DFEE CI+   R +  + N+   E + VT +  E    R+ ++ +    +K+ +  ++
Sbjct: 1053 VHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVD 1112

Query: 3661 TKIDHISN 3684
             ++  + +
Sbjct: 1113 IRLAQLED 1120


>gi|23510305|ref|NP_700466.1| transient receptor potential cation
            channel, subfamily M, member 6; transient receptor
            potential cation channel 6/channel-kinase 2 [Mus
            musculus]
 gi|23306485|gb|AAN15217.1| transient receptor potential cation
            channel 6/channel-kinase 2 [Mus musculus]
          Length = 2028

 Score =  676 bits (1745), Expect = 0.0
 Identities = 405/1268 (31%), Positives = 678/1268 (52%), Gaps = 74/1268 (5%)
 Frame = +1

Query: 133  WIENTFEKRECIRFAALPKDPERCG-------------CGRPLSAHTPASTFFSTLPVHL 273
            WIE  F KREC +F    KDP RC              CGR +  H      ++
Sbjct: 7    WIEGVFYKRECNKFIPSSKDPHRCTPGCQICHNLVRCYCGRLIEEHHGLDRAWNLSVTEG 66

Query: 274  LEKEQQTWTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLMEKVWGL 453
               EQ  W++  +T  S TD FGTI FQ G H H ++Y+R S+D++   +++LM K W +
Sbjct: 67   HGDEQ--WSVEKHTVKSPTDTFGTINFQDGEHIHHSKYIRTSWDTKSDHLLHLMLKEWNM 124

Query: 454  EAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVAKALDE 633
            E P+LVI+VHGG+ NF++  +L   F +G++KAA+TTGAWIIT G++SGV +HV  AL
Sbjct: 125  ELPKLVISVHGGLQNFKISSKLKETFSQGLVKAAETTGAWIITEGINSGVSKHVGDAL-- 182

Query: 634  AGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRHSYFLL 813
               S++   +I T+GI PWGVI+ +  L+ ++    Y      + + +  LN  HS+F+L
Sbjct: 183  KAHSSKSLRKIWTVGIPPWGVIENQRELVGKDVVCMYQTLGNPL-SKLTTLNCMHSHFIL 241

Query: 814  ADNGTVGRFGADLHLRQNLENHIA---TFGCNGRKVPVVCTLLEGGISSINAIHDYVTMK 984
             D+GTVG +G +  LR+NLE H++      C+ + VPVV  ++EGG + I  +  + T+K
Sbjct: 242  CDDGTVGMYGNEEKLRRNLEKHLSMQKIHTCSRQGVPVVGLVMEGGPNVI--LWVWETVK 299

Query: 985  PDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMVFPET--DQEEMFRK 1158
               P +VC+G+GRAAD+++F  +++   G    +V E+L  LI+ +F  +    + +F+
Sbjct: 300  NKEPVVVCEGTGRAADLLAFTYKHLEDGGILRPQVKEELFCLIQNMFNFSLRQSKHLFQI 359

Query: 1159 ITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCL 1338
            + EC++  D + IF    EE +D+D  IL+ +L+  +L   EQL L ++W+R+D+AK  +
Sbjct: 360  LMECMVHKDSITIFDADSEEHQDLDLAILTALLKGTSLSISEQLNLAMAWDRMDIAKKHI 419

Query: 1339 FSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDDINSAH 1518
             + G+ W    LE+AM DAL  DRVDFV+ L+ENGV++  FL+I RLE LYN     +
Sbjct: 420  LTYGQHWKPGALEQAMLDALVMDRVDFVKLLIENGVNLHRFLTIPRLEELYNTKQGPTNK 479

Query: 1519 SVRNWMENFDSMDPHTYL-----TIPMIGQVVEKLMGNAFQLYYTSRSFKGKYDRYKRIN 1683
             +R+ +++   +  HT L     T+  IG V+E L+G A++  YT +SF+  Y+   R +
Sbjct: 480  FLRHLVQD---VKQHTLLSSYRITLIDIGLVIEYLIGGAYRSSYTRKSFRILYNNLYRKH 536

Query: 1684 QS-------------------------------SYFHR-------KRKIVQKELFKKKSD 1749
            +S                               S F R       K K    +  KKKS
Sbjct: 537  KSVSSFAQGLSQHSLHQRHSLRNRKESSESTLHSQFFRTAQPYKSKEKPEDSQKSKKKSK 596

Query: 1750 DQINDNEE-EDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAK 1926
            ++ + +EE E   F YP+NDLL+WAVL  R  MA   W HGE+A  K ++A  LY+A A+
Sbjct: 597  ERQSLSEEPEAAGFIYPYNDLLVWAVLMKRQNMAMFFWQHGEEATVKAVIASILYRAMAR 656

Query: 1927 IAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSL 2106
             A++  +  + ++ L + + +  + A+++L++ ++ +    ++LL  EL +W N+ CL L
Sbjct: 657  EAKESNMVDDTSEELKNYSEQFGQLALDVLEKAFKQNEPMAMKLLTYELKNWSNSTCLKL 716

Query: 2107 AVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTA 2286
            AV    + F++H C Q+LL ++W G LK+R  S ++++ +++ PP IL + +K K   +
Sbjct: 717  AVSGGLRPFVSHSCTQMLLTDMWMGRLKMRKNSWLKIIISILLPPMILTLEFKSKAEMSH 776

Query: 2287 RLLSEETPEQLPYPRESITSTTSNR----YRYSKGPEEQKETLLEKGSYTKKVTIISSRK 2454
               S++      Y  + +++T  +     Y   +GP+E+ +  L
Sbjct: 777  VPQSQDFQFTWNYSDQGLSNTKESACVKDYDLERGPDEKPDEPLH--------------- 821

Query: 2455 NXXXXXXXXXXXXXXFKREPQ-LNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLL 2631
                            +  PQ L    R   FYS+P  KFW + +A+L FL   T  +L+
Sbjct: 822  -------------LDLRNVPQSLPWTRRVYEFYSAPFVKFWFYTMAYLAFLMLFTYTVLV 868

Query: 2632 ETSLKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFL 2811
            E   +PS +EW+  IY  T ++E +R++  SE S+  +KVK++ ++++N+  + A+  F
Sbjct: 869  EMQPQPSVHEWLVIIYIFTNAIEKVREICISEPSKFKQKVKMWLSEYWNLMETVAIGLFA 928

Query: 2812 VGYGFRLVPMYRHSWGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICV 2991
            VG+G R       + GR++     + ++ ++ ++ +V+   GPY+ M AKM  +M YI +
Sbjct: 929  VGFGLRWGHPPLQTAGRLIYCIDIIFWFSRLMDFFAVNQHAGPYVTMIAKMAANMFYIVI 988

Query: 2992 LLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEIDTCGDEGIRCF 3171
            ++ + L++FGV R+A+  P  +   W L R+I ++PY+M+YGEVYA +ID C +E   C
Sbjct: 989  IMAIVLLSFGVARKAILSPK-EPPSWRLARDIVFEPYWMMYGEVYASDIDVCSNE-TSCP 1046

Query: 3172 PGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPF 3351
            PG F+ P L                       Y D    S ++W + RY+ +M YH  P+
Sbjct: 1047 PGSFLTPFLQAVYLFVQYIIMVNLLIACFNNIYLDIKSISNKLWKYNRYRYIMTYHQKPW 1106

Query: 3352 LPPPFSIFAHVYHFIDYLYNLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTR 3531
            LPPPF +  H+   +  L     P  +    +  +KL +T+D++K++ DFEE C++
Sbjct: 1107 LPPPFILLNHLCLLLRGLCCRPAPQDQE-EGDGGLKLYLTKDDLKKLHDFEEQCVEKYFH 1165

Query: 3532 IRKLKLNTKEPLSVTDLTELTCQRVHDLM-------QENFLLKSRVYDIETKIDHISNSS 3690
             +   LN     S  +   +T +RV ++        ++   +K  +  +++++ H+ + S
Sbjct: 1166 EKTEGLN----CSFEEQIRMTSERVSEMFFQLKEMNEKVSFIKDSLLSLDSQVGHLQDLS 1221

Query: 3691 DEVVQILK 3714
               V  LK
Sbjct: 1222 AITVDTLK 1229


>gi|45935364|ref|NP_996829.1| transient receptor potential cation
            channel, subfamily M, member 3 isoform f; melastatin 2;
            long transient receptor potential channel 3 [Homo
            sapiens]
 gi|27597211|dbj|BAC55105.1| hypothetical protein [Homo sapiens]
 gi|28626257|gb|AAO49158.1| calcium-permeable store-operated channel
            TRPM3f [Homo sapiens]
          Length = 1579

 Score =  674 bits (1740), Expect = 0.0
 Identities = 396/1155 (34%), Positives = 638/1155 (54%), Gaps = 55/1155 (4%)
 Frame = +1

Query: 385  YVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTT 564
            YVR+S+D++P  +++LM K W LE P+L+I+VHGG+ NFEL+ +L ++F KG++KAA TT
Sbjct: 2    YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 565  GAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYY 744
            GAWI T G+++GV+RHV  AL +   +++ R +I TIGIAPWG+++ +E LI ++    Y
Sbjct: 62   GAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPY 119

Query: 745  DVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN-------- 900
               S +  + + +LN  HS+F+LADNGT G++GA++ LR+ LE HI+    N
Sbjct: 120  QTMS-NPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPFFS 178

Query: 901  --------------------GRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSG 1020
                                G+ VPVV  ++EGG + I+ + +Y+   P +P +VCDGSG
Sbjct: 179  LDSRLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSG 238

Query: 1021 RAADIISFAARYINSDGTFAAEVGEKLRNLIKMVF--PETDQEEMFRKITECVIRDDLLR 1194
            RA+DI++F  +Y    G     + ++L   I+  F    T  + +F  + EC+ + +L+
Sbjct: 239  RASDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELIT 298

Query: 1195 IFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVL 1374
            +FR G E  +D+D  IL+ +L+  N    +QL+L L+WNRVD+A+S +F  G++W    L
Sbjct: 299  VFRMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSL 358

Query: 1375 EKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDDINS---AHSVRNWMENF 1545
            E+AM DAL  DRVDFV+ L+ENGVSM  FL+I+RLE LYN     S    H VR+  +
Sbjct: 359  EQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKG- 417

Query: 1546 DSMDPHTYLTIPMIGQVVEKLMGNAFQLYYTSRSFKGKYDRY---KRINQSSYFHRKRKI 1716
             ++ P   +++  IG V+E LMG A++  YT + F+  Y      KR         +  I
Sbjct: 418  -NLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDI 476

Query: 1717 V----QKELFKKKSDDQINDNEEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMA 1884
                 +K   K++ +  I+ ++ E   F +PF++L++WAVL  R  MA   W HGE+AMA
Sbjct: 477  PLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMA 536

Query: 1885 KCLLAIRLYKATAKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLR 2064
            K L+A +L KA A  A +  +  + ++ L  N+    + A+ELLDQ Y+ D    ++LL
Sbjct: 537  KALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLT 596

Query: 2065 MELPHWGNNNCLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPA 2244
             EL +W N  CL LAV A  + F+AH C Q+LL ++W G L++R  S ++V+  ++ PP+
Sbjct: 597  YELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPS 656

Query: 2245 ILFMAYKPKHSKTARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYT 2424
            IL + +K K             + +PY      S     +   K  EE ++   EK
Sbjct: 657  ILSLEFKNK-------------DDMPY-----MSQAQEIHLQEKEAEEPEKPTKEKEEED 698

Query: 2425 KKVTIISSRKNXXXXXXXXXXXXXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFL 2604
             ++T +  R N                R   L +  +   FY++PI KFW + +A++ +L
Sbjct: 699  MELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGR--KIYEFYNAPIVKFWFYTLAYIGYL 756

Query: 2605 TTQTCILLLETSLKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIW 2784
                 I+L++    PS  EWI   Y  TL +E +R+++ SE  ++ +KVKV+  +++N+
Sbjct: 757  MLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVT 816

Query: 2785 TSAALLFFLVGYGFRLVPMYRHSWGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKM 2964
               A+L F VG   RL      S GRV+   + + +Y+++ +   V+  LGPY+ M  KM
Sbjct: 817  DLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKM 876

Query: 2965 VWSMCYICVLLLVPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEID- 3141
            +  M Y  +++LV LM+FGV RQA+  PN ++  W L +NIFY PY+M+YGEV+A +ID
Sbjct: 877  MIDMMYFVIIMLVVLMSFGVARQAILFPN-EEPSWKLAKNIFYMPYWMIYGEVFADQIDP 935

Query: 3142 TCGDEGIR----------CFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKS 3291
             CG    R          C  G +I P +M                      + +    S
Sbjct: 936  PCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSIS 995

Query: 3292 KEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFIDYL-YNLRRPDTKRFRSEHSIKLSV 3468
             ++W FQRYQ +M +H+ P LPPP  IF+H+     +L    R+ ++     ++ +KL +
Sbjct: 996  NQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFI 1055

Query: 3469 TEDEMKRIQDFEEDCIDTLTRIRKLKLNTK--EPLSVT-DLTELTCQRVHDLMQENFLLK 3639
            T+DE+K++ DFEE CI+   R +  + N+   E + VT +  E    R+ ++ +    +K
Sbjct: 1056 TDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMK 1115

Query: 3640 SRVYDIETKIDHISN 3684
            + +  ++ ++  + +
Sbjct: 1116 ASLQTVDIRLAQLED 1130


>gi|27597213|dbj|BAC55106.1| hypothetical protein [Homo sapiens]
          Length = 1526

 Score =  660 bits (1702), Expect = 0.0
 Identities = 383/1120 (34%), Positives = 625/1120 (55%), Gaps = 20/1120 (1%)
 Frame = +1

Query: 385  YVRLSYDSEPLDVMYLMEKVWGLEAPRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTT 564
            YVR+S+D++P  +++LM K W LE P+L+I+VHGG+ NFEL+ +L ++F KG++KAA TT
Sbjct: 2    YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 565  GAWIITSGLDSGVVRHVAKALDEAGISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYY 744
            GAWI T G+++GV+RHV  AL +   +++ R +I TIGIAPWG+++ +E LI ++    Y
Sbjct: 62   GAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPY 119

Query: 745  DVHSLSVNANVGILNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCN---GRKVP 915
               S  ++  + +LN  HS+F+LADNGT G++GA++ LR+ LE HI+    N   G+ VP
Sbjct: 120  QTMSNPMS-KLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVP 178

Query: 916  VVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSDGTFAAEVGE 1095
            VV  ++EGG + I+ + +Y+   P +P +VCDGSGRA+DI++F  +Y    G     + +
Sbjct: 179  VVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRD 238

Query: 1096 KLRNLIKMVFP--ETDQEEMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQN 1269
            +L   I+  F    T  + +F  + EC+ + +L+ +FR G E  +D+D  IL+ +L+  N
Sbjct: 239  QLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGAN 298

Query: 1270 LPPDEQLALTLSWNRVDLAKSCLFSNGRKWSSDVLEKAMNDALYWDRVDFVECLLENGVS 1449
                +QL+L L+WNRVD+A+S +F  G++W    LE+AM DAL  DRVDFV+ L+ENG
Sbjct: 299  ASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGRH 358

Query: 1450 MKNFLSINRLENLYNMDDINSAHSVRNWMENFDSMDPHTYLTIPMIGQVVEKLMGNAFQL 1629
              +         LY        H VR+  +   ++ P   +++  IG V+E LMG A++
Sbjct: 359  GPS-------NTLY--------HLVRDVKKG--NLPPDYRISLIDIGLVIEYLMGGAYRC 401

Query: 1630 YYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDNEEEDFSFAYPFNDL 1809
             YT + F+  Y       +     R+ +   K   K++ +  I+ ++ E   F +PF++L
Sbjct: 402  NYTRKRFRTLYHNLFGPKRDDIPLRRGRKTTK---KREEEVDIDLDDPEINHFPFPFHEL 458

Query: 1810 LIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDNAVK 1989
            ++WAVL  R  MA   W HGE+AMAK L+A +L KA A  A +  +  + ++ L  N+
Sbjct: 459  MVWAVLMKRQKMALFFWQHGEEAMAKALVAYKLCKAMAHEASENDMVDDISQELNHNSRD 518

Query: 1990 CREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQILLAE 2169
              + A+ELLDQ Y+ D    ++LL  EL +W N  CL LAV A  + F+AH C Q+LL +
Sbjct: 519  FGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTD 578

Query: 2170 LWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLPYPRESITST 2349
            +W G L++R  S ++V+  ++ PP+IL + +K K             + +PY      S
Sbjct: 579  MWMGRLRMRKNSGLKVILGILLPPSILSLEFKNK-------------DDMPY-----MSQ 620

Query: 2350 TSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNXXXXXXXXXXXXXXFKREPQLNKF 2529
                +   K  EE ++   EK     ++T +  R N                R   L +
Sbjct: 621  AQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGR- 679

Query: 2530 ERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETSLKPSKYEWITFIYTVTLSVEHIR 2709
             +   FY++PI KFW + +A++ +L     I+L++    PS  EWI   Y  TL +E +R
Sbjct: 680  -KIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMR 738

Query: 2710 KLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPMYRHSWGRVLLSFSNVL 2889
            +++ SE  ++ +KVKV+  +++N+    A+L F VG   RL      S GRV+   + +
Sbjct: 739  EILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIY 798

Query: 2890 FYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKDWHW 3069
            +Y+++ +   V+  LGPY+ M  KM+  M Y  +++LV LM+FGV RQA+  PN ++  W
Sbjct: 799  WYIRLLDIFGVNKYLGPYVMMIGKMMIEMMYFVIIMLVVLMSFGVARQAILFPN-EEPSW 857

Query: 3070 LLVRNIFYKPYFMLYGEVYAGEID-TCGDEGIR----------CFPGYFIPPLLMXXXXX 3216
             L +NIFY PY+M+YGEV+A +ID  CG    R          C  G +I P +M
Sbjct: 858  KLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLL 917

Query: 3217 XXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLMEYHDSPFLPPPFSIFAHVYHFI 3396
                             + +    S ++W FQRYQ +M +H+ P LPPP  IF+H+
Sbjct: 918  VANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIF 977

Query: 3397 DYL-YNLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEEDCIDTLTRIRKLKLNTK--EPL 3567
             +L    R+ ++     ++ +KL +T+DE+K++ DFEE CI+   R +  + N+   E +
Sbjct: 978  QHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERI 1037

Query: 3568 SVT-DLTELTCQRVHDLMQENFLLKSRVYDIETKIDHISN 3684
             VT +  E    R+ ++ +    +K+ +  ++ ++  + +
Sbjct: 1038 RVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLED 1077


>gi|50752897|ref|XP_425066.1| PREDICTED: similar to transient receptor
            potential cation channel, subfamily M, member 1;
            melastatin 1 [Gallus gallus]
          Length = 1574

 Score =  641 bits (1653), Expect = 0.0
 Identities = 394/1271 (30%), Positives = 664/1271 (51%), Gaps = 70/1271 (5%)
 Frame = +1

Query: 112  TEKLSPPWIENTFEKRECIRFAALPKDPERCGCGRPLSAHTPASTFFSTLP----VHLLE 279
            ++K    WIE TF KRECI   A  KD  RC CG+ ++ H P     +          +E
Sbjct: 17   SQKGQKAWIEKTFSKRECIYVIANNKDISRCCCGQLITQHIPPPPSTTANKNGEETKQVE 76

Query: 280  KEQQTWTIANNTQTSTTDAFGTIVFQGGAHAHKAQYVRLSYDSEPLDVMYLMEKVWGLEA 459
             + + W+++ +TQT  TDA+G + FQGG H++KA Y+R+SYD++P  +++LM K W LE
Sbjct: 77   AQPEKWSVSKHTQTYPTDAYGNLEFQGGGHSNKAMYIRVSYDTKPDSLLHLMVKDWQLEL 136

Query: 460  PRLVITVHGGMSNFELEERLGRLFRKGMLKAAQTTGAWIITSGLDSGVVRHVAKALDEAG 639
            P+L+I+VHGG+ NFE++ +L ++F KG++KAA TTGAWI T G+ +GV+RHV  AL +
Sbjct: 137  PKLLISVHGGLQNFEMQPKLKQVFGKGLIKAAMTTGAWIFTGGVSTGVIRHVGDALKDH- 195

Query: 640  ISARMRSQIVTIGIAPWGVIKRKERLIRQNEHVYYDVHSLSVNANVGILNDRHSYFLLAD 819
             S++ R +I  IGIAPWG+++ KE LI ++    Y   S  + + + +LN  H++F+LAD
Sbjct: 196  -SSKSRGRICAIGIAPWGIVENKEDLIGKDVTRVYQTMSNPL-SKLSVLNSSHTHFILAD 253

Query: 820  NGTVGRFGADLHLRQNLENHIATFGCN---GRKVPVVCTLLEGGISSINAIHDYVTMKPD 990
            NGT+G++GA++ LR+ LE HI+    N   G+ VPVV  ++EGG + I+ + + +  +P
Sbjct: 254  NGTLGKYGAEVKLRRQLEKHISLQKINTRLGQGVPVVGLIVEGGPNVISIVLECLREEPP 313

Query: 991  IPAIVCDGSGRAADIISFAARYINSDGTFAAEVGEKLRNLIKMVF--PETDQEEMFRKIT 1164
            +P ++CDGSGRA+DI+SFA +Y    G  +  + ++L   I+  F        ++F  +
Sbjct: 314  LPVVICDGSGRASDILSFAHKYSEEGGIISESLRDQLLVTIQKTFNYSRNQAHQLFIILM 373

Query: 1165 ECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCLFS 1344
            EC+ + +L+ +FR G E ++D++  IL+ +L+  N    +QL+L L+WNRVD+A+S +F
Sbjct: 374  ECMKKKELITVFRMGSEGQQDIEMSILTALLKGTNASAPDQLSLALAWNRVDIARSQIFV 433

Query: 1345 NGRKW-------------------SSDVLEKAM--------------------NDALYWD 1407
             G  W                   S  V  KA                      D    +
Sbjct: 434  FGHHWPPLGSLTAGDGTAPEKEKKSPAVQTKAARGKGKGKKKGGKVKEEPEEETDPRKLE 493

Query: 1408 RVDFVECLLENGVSMKNFLSINRLE--NLYNMDDINSAHSVR----NWMENFDSMDPHTY 1569
             +++V  L +   +M + L ++R++   L   + +N  H +       + N  ++ P  +
Sbjct: 494  LLNWVNSLEQ---AMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTGNLPPDYH 550

Query: 1570 LTIPMIGQVVEKLMGNAFQLYYTSRSFKGKYDRY---KRINQSSYFHRKRKIVQKELFKK 1740
            +++  IG V+E LMG A++  YT +SF+  Y+     KR ++     +K+K       KK
Sbjct: 551  ISLIDIGLVLEYLMGGAYRCNYTRKSFRTLYNNLFGPKRDDEPPTKGKKKK------KKK 604

Query: 1741 KSDDQINDNEEEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKAT 1920
            + +  I+ ++ E   F YPF++L++WAVL  R  MA  +W  GE+ MAK L+A +LYK+
Sbjct: 605  EEEIDIDVDDPEVSRFQYPFHELMLWAVLMKRQKMALFLWQRGEETMAKALVACKLYKSM 664

Query: 1921 AKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCL 2100
            A  + +  L  + ++ L +N+    + A+ELLDQ Y+ D    ++LL  EL +W N+ CL
Sbjct: 665  AHESSESELVDDISQDLDNNSKDFGQLAVELLDQSYKHDEQIAMKLLTYELKNWSNSTCL 724

Query: 2101 SLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSK 2280
             LAV A  + F+AH C Q+LL ++W G L++R    ++V+  ++ PP ILF+ ++  +
Sbjct: 725  KLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILFPPTILFLEFR-SYDD 783

Query: 2281 TARLLSEETPEQLPYPRESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNX 2460
             +   S E  E      E++ +      R  KG EE
Sbjct: 784  YSYQTSRENEEGKEKEEENVDANVDTGSR--KGDEENGN--------------------- 820

Query: 2461 XXXXXXXXXXXXXFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLETS 2640
                          K++  L    +   FY++PI KFW
Sbjct: 821  --------------KKQNSLPIGTKIYEFYNAPIVKFW---------------------- 844

Query: 2641 LKPSKYEWITFIYTVTLSVEHIRKLMTSEGSRINEKVKVFYAKWYNIWTSAALLFFLVGY 2820
                        YT+          + SE  ++++KVKV+  +++NI    A+  F++G
Sbjct: 845  -----------FYTI----------LMSEPGKLSQKVKVWLQEYWNITDLVAISVFMIGA 883

Query: 2821 GFRLVPMYRHSWGRVLLSFSNVLFYMKIFEYLSVHPLLGPYIQMAAKMVWSMCYICVLLL 3000
              RL       +GRV+     + +Y+++ +   V+  LGPY+ M  KM+  M Y  V++L
Sbjct: 884  ILRLQNQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIML 943

Query: 3001 VPLMAFGVNRQALTEPNVKDWHWLLVRNIFYKPYFMLYGEVYAGEID-TCGD-----EGI 3162
            V LM+FGV RQA+  P+ ++  W L RNIFY PY+M+YGEV+A +ID  CGD     +G
Sbjct: 944  VVLMSFGVARQAILHPD-EEPSWRLARNIFYMPYWMIYGEVFADQIDPPCGDNLYDEDGK 1002

Query: 3163 R---CFPGYFIPPLLMXXXXXXXXXXXXXXXXXXXXXXYNDSIEKSKEIWLFQRYQQLME 3333
            R   C PG ++ P +M                      + +    S ++W FQRYQ +M
Sbjct: 1003 RLPPCIPGAWLTPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMT 1062

Query: 3334 YHDSPFLPPPFSIFAHVYHFIDYL-YNLRRPDTKRFRSEHSIKLSVTEDEMKRIQDFEED 3510
            +HD P LPPP  IF+H+Y  I  +    ++ +  +   +  +KL + ++E+K++ +FEE
Sbjct: 1063 FHDRPVLPPPMIIFSHLYIIIKRVCCRCKKREGDQDERDRGLKLFLNDEELKKLYEFEEQ 1122

Query: 3511 CIDTLTRIR--KLKLNTKEPLSVT-DLTELTCQRVHDLMQENFLLKSRVYDIETKIDHIS 3681
            C++   + +  + + +  E + VT +  E    R+ ++ +    +K+ +  ++ ++  +
Sbjct: 1123 CVEEYFQEKEDEQQSSNDERIRVTSERVENMSMRLEEVNEREHFMKASLQTVDLRLSQLE 1182

Query: 3682 NSSDEVVQILK 3714
              S  +V  L+
Sbjct: 1183 ELSGRMVNALE 1193




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