Homology by BLASTX
BLASTX 2.2.4 [Aug-26-2002]
Query= F42E11_1
(2641 letters)
Database: /home/niguts/usr02/tshini/ykclst/db/nr.seq
1,967,186 sequences; 661,712,633 total letters
Score E
Sequences producing significant alignments: (bits) Value
gi|17569143|ref|NP_509901.1| P-GlycoProtein related (pgp-3) [Cae... 1614 0.0
gi|283552|pir||S27338 P-glycoprotein C - Caenorhabditis elegans ... 1578 0.0
gi|39594784|emb|CAE70652.1| Hypothetical protein CBG17357 [Caeno... 1514 0.0
gi|39594783|emb|CAE70651.1| Hypothetical protein CBG17356 [Caeno... 1365 0.0
gi|17569145|ref|NP_509902.1| P-GlycoProtein related (pgp-4) [Cae... 1365 0.0
gi|39595964|emb|CAE67467.1| Hypothetical protein CBG12969 [Caeno... 753 0.0
gi|17558664|ref|NP_507487.1| P-GlycoProtein related (pgp-9) [Cae... 732 0.0
gi|39587899|emb|CAE67917.1| Hypothetical protein CBG13514 [Caeno... 712 0.0
gi|39585393|emb|CAE61715.1| Hypothetical protein CBG05664 [Caeno... 710 0.0
gi|283551|pir||S27337 multidrug resistance protein A - Caenorhab... 692 0.0
gi|17541710|ref|NP_502413.1| P-GlycoProtein related (pgp-1) [Cae... 692 0.0
gi|17567269|ref|NP_510128.1| P-GlycoProtein related (146.8 kD) (... 692 0.0
gi|39587988|emb|CAE57219.1| Hypothetical protein CBG00079 [Caeno... 689 0.0
gi|72477|pir||DVHY1C multidrug resistance protein 1 - Chinese ha... 675 0.0
gi|126924|sp|P21448|MDR1_CRIGR Multidrug resistance protein 1 (P... 675 0.0
gi|191157|gb|AAA37005.1| p-glycoprotein 675 0.0
gi|39595370|emb|CAE60408.1| Hypothetical protein CBG04013 [Caeno... 673 0.0
gi|22759019|gb|AAN05645.1| multidrug resistance p-glycoprotein [... 673 0.0
gi|46394982|gb|AAS91647.1| multidrug resistance protein 1; P-gly... 673 0.0
gi|8926217|gb|AAF81747.1| his-tagged-multidrug resistance glycop... 673 0.0
gi|17508505|ref|NP_491707.1| P-GlycoProtein related (pgp-2) [Cae... 672 0.0
gi|307180|gb|AAA59575.1| P-glycoprotein [Homo sapiens] 672 0.0
gi|2506118|sp|P08183|MDR1_HUMAN Multidrug resistance protein 1 (... 672 0.0
gi|2353264|gb|AAB69423.1| P-glycoprotein [Homo sapiens] 672 0.0
gi|2852441|gb|AAC02113.1| multidrug resistance p-glycoprotein [C... 672 0.0
gi|72475|pir||DVMS1A multidrug resistance protein 1a - mouse (fr... 671 0.0
gi|6755048|ref|NP_035206.1| ATP-binding cassette, sub-family B (... 671 0.0
gi|266517|sp|P21447|MDR3_MOUSE Multidrug resistance protein 3 (P... 671 0.0
gi|126928|sp|P21449|MDR2_CRIGR Multidrug resistance protein 2 (P... 671 0.0
gi|42741659|ref|NP_000918.2| ATP-binding cassette sub-family B m... 671 0.0
gi|45382457|ref|NP_990225.1| ABC transporter protein [Gallus gal... 671 0.0
gi|31442763|gb|AAN07780.2| multidrug resistance p-glycoprotein [... 671 0.0
gi|46394984|gb|AAS91648.1| multidrug resistance protein; P-glyco... 671 0.0
gi|22775296|gb|AAN07779.1| multidrug resistance p-glycoprotein [... 671 0.0
gi|25297453|pir||D87789 protein C34G6.4 [imported] - Caenorhabdi... 670 0.0
gi|833699|gb|AAA75000.1| multidrug resistance protein >gnl|BL_OR... 669 0.0
gi|6755046|ref|NP_035205.1| ATP-binding cassette, sub-family B (... 668 0.0
gi|2149087|gb|AAB58489.1| multidrug resistance protein-1 [Ovis a... 667 0.0
gi|39587987|emb|CAE57218.1| Hypothetical protein CBG00078 [Caeno... 667 0.0
gi|1362689|pir||S55692 multidrug resistance protein homolog (mdr... 666 0.0
gi|39587992|emb|CAE57223.1| Hypothetical protein CBG00086 [Caeno... 665 0.0
gi|25453370|ref|NP_036755.2| P-glycoprotein/multidrug resistance... 665 0.0
gi|25453402|ref|NP_596892.1| ATP-binding cassette, sub-family B ... 665 0.0
gi|46394986|gb|AAS91649.1| multidrug resistance protein 1a; P-gl... 665 0.0
gi|7511698|pir||T31073 multidrug resistance p-glycoprotein - nem... 664 0.0
gi|48267183|gb|AAQ63650.3| multi-drug resistance P-glycoprotein ... 664 0.0
gi|50732589|ref|XP_418707.1| PREDICTED: similar to ATP-binding c... 659 0.0
gi|6679297|ref|NP_032856.1| ATP-binding cassette, sub-family B (... 659 0.0
gi|4505771|ref|NP_000434.1| ATP-binding cassette, subfamily B, m... 658 0.0
gi|6981354|ref|NP_036822.1| ATP-binding cassette, sub-family B (... 656 0.0
gi|1170902|sp|P43245|MDR1_RAT Multidrug resistance protein 1 (P-... 655 0.0
gi|40644181|emb|CAC86600.1| multidrug resistance protein [Platic... 653 0.0
gi|126930|sp|P23174|MDR3_CRIGR Multidrug resistance protein 3 (P... 653 0.0
gi|9961250|ref|NP_061337.1| ATP-binding cassette, subfamily B, m... 651 0.0
gi|17567265|ref|NP_510126.1| P-GlycoProtein related (pgp-12) [Ca... 643 0.0
gi|17567267|ref|NP_510127.1| P-GlycoProtein related (pgp-13) [Ca... 631 e-179
gi|39587990|emb|CAE57221.1| Hypothetical protein CBG00083 [Caeno... 631 e-179
gi|45361353|ref|NP_989254.1| hypothetical protein MGC76216 [Xeno... 630 e-179
gi|27656757|gb|AAO20901.1| Mdr3 [Takifugu rubripes] 624 e-177
gi|9961252|ref|NP_061338.1| ATP-binding cassette, subfamily B, m... 621 e-176
gi|38073917|ref|XP_283101.2| similar to multidrug resistance p-g... 619 e-175
gi|31213429|ref|XP_315658.1| ENSANGP00000021663 [Anopheles gambi... 615 e-174
gi|4574224|gb|AAD23956.1| multidrug resistance transporter homol... 613 e-174
gi|13929072|ref|NP_113948.1| ATP-binding cassette, sub-family B ... 613 e-174
gi|7514034|pir||T42228 P-glycoprotein sister - rat >gnl|BL_ORD_I... 613 e-174
gi|11038656|ref|NP_066302.1| ATP-binding cassette, sub-family B,... 608 e-172
gi|50507726|emb|CAA94219.3| Hypothetical protein T21E8.2 [Caenor... 606 e-171
gi|6472653|dbj|BAA87071.1| multi-drug resistance related mRNA [F... 606 e-171
gi|17569907|ref|NP_509813.1| P-GlycoProtein related (pgp-6) [Cae... 605 e-171
gi|4704820|gb|AAD28285.1| bile salt export pump [Homo sapiens] 603 e-171
gi|27656758|gb|AAO20902.1| Mdr2 [Takifugu rubripes] 603 e-171
gi|12643301|sp|O95342|AB11_HUMAN Bile salt export pump (ATP-bind... 603 e-171
gi|21536378|ref|NP_003733.2| ATP-binding cassette, sub-family B ... 603 e-171
gi|17569909|ref|NP_509812.1| P-GlycoProtein related (pgp-7) [Cae... 599 e-170
gi|22026798|ref|NP_523740.2| CG8523-PA [Drosophila melanogaster]... 598 e-169
gi|266518|sp|Q00449|MDR4_DROME Multidrug resistance protein homo... 598 e-169
gi|24653245|ref|NP_523724.2| CG3879-PA [Drosophila melanogaster]... 598 e-169
gi|40644167|emb|CAC86593.1| sister of P-glycoprotein [Platichthy... 597 e-169
gi|39594939|emb|CAE70807.1| Hypothetical protein CBG17569 [Caeno... 595 e-168
gi|48094917|ref|XP_394305.1| similar to ENSANGP00000021663 [Apis... 595 e-168
gi|5733124|gb|AAD49436.1| P-glycoprotein [Onchocerca volvulus] 593 e-168
gi|14030565|gb|AAK52958.1| bile salt export pump [Raja erinacea] 590 e-167
gi|157873|gb|AAA16186.1| P-glycoprotein/multidrug resistance pro... 590 e-167
gi|1079107|pir||A47377 multidrug resistance protein Mdr50 - frui... 590 e-167
gi|33307712|gb|AAQ03033.1| P-glycoprotein [Homo sapiens] 587 e-166
gi|7511495|pir||T18940 multidrug resistance protein homolog - Ca... 587 e-166
gi|17550138|ref|NP_509810.1| P-GlycoProtein related (pgp-5) [Cae... 587 e-166
gi|25146777|ref|NP_509811.2| P-GlycoProtein related (pgp-8) [Cae... 586 e-166
gi|24659289|ref|NP_648040.1| CG10226-PA [Drosophila melanogaster... 582 e-164
gi|18496818|gb|AAL74250.1| ABC transporter AbcB3 [Dictyostelium ... 578 e-163
gi|50750485|ref|XP_422016.1| PREDICTED: similar to liver bile sa... 577 e-163
gi|12585141|sp|Q9N0V3|AB11_RABIT Bile salt export pump (ATP-bind... 576 e-163
gi|393116|gb|AAA93553.1| P-glycoprotein 5 575 e-162
gi|422286|pir||S30328 multidrug resistance protein 2 - Entamoeba... 575 e-162
gi|36413607|ref|NP_848654.2| ATP-binding cassette, sub-family B,... 575 e-162
gi|13641444|gb|AAK31736.1| p-glycoprotein [Mucor racemosus] 570 e-161
gi|21464386|gb|AAM51996.1| RE14657p [Drosophila melanogaster] 568 e-160
gi|17136662|ref|NP_476831.1| CG10181-PA [Drosophila melanogaster... 568 e-160
gi|103252|pir||B41249 multidrug resistance protein homolog Mdr65... 568 e-160
gi|422285|pir||S30327 multidrug resistance protein 1 - Entamoeba... 568 e-160
gi|46390962|dbj|BAD16475.1| putative multidrug resistance p-glyc... 566 e-160
gi|18496816|gb|AAL74249.1| ABC transporter AbcB2 [Dictyostelium ... 566 e-160
gi|16304396|gb|AAL15148.1| multidrug resistance transporter-like... 565 e-159
gi|2673951|gb|AAB88657.1| multidrug resistance protein 1 [Asperg... 565 e-159
gi|5456701|gb|AAD43626.1| multidrug resistance protein MDR [Emer... 564 e-159
gi|49089458|ref|XP_406437.1| hypothetical protein AN2300.2 [Aspe... 564 e-159
gi|50260330|gb|EAL22989.1| hypothetical protein CNBA7570 [Crypto... 561 e-158
gi|15228695|ref|NP_191774.1| multidrug resistant (MDR) ABC trans... 560 e-158
gi|22535563|dbj|BAC10738.1| putative multidrug resistance protei... 559 e-157
gi|11346278|pir||T43261 multidrug resistance protein 1 - fungus ... 559 e-157
gi|27368867|emb|CAD59591.1| MDR-like ABC transporter [Oryza sati... 556 e-156
gi|50543630|ref|XP_499981.1| hypothetical protein [Yarrowia lipo... 554 e-156
gi|15229473|ref|NP_189475.1| ABC transporter family protein [Ara... 553 e-155
gi|38345252|emb|CAD41096.2| OSJNBb0011N17.13 [Oryza sativa (japo... 553 e-155
gi|50546639|ref|XP_500789.1| hypothetical protein [Yarrowia lipo... 551 e-155
gi|15147363|gb|AAG01549.3| multidrug resistance protein MDR [Tri... 551 e-155
gi|15217785|ref|NP_171753.1| multidrug resistance P-glycoprotein... 551 e-155
gi|15226477|ref|NP_182223.1| multidrug resistant (MDR) ABC trans... 550 e-155
gi|18033873|gb|AAL57243.1| ATP-binding cassette transporter ABC4... 549 e-154
gi|34894326|ref|NP_908488.1| unnamed protein product [Oryza sati... 548 e-154
gi|15237456|ref|NP_199466.1| ABC transporter family protein [Ara... 548 e-154
gi|15228506|ref|NP_189528.1| multidrug resistance P-glycoprotein... 548 e-154
gi|24324262|gb|AAN28720.2| MDR-like p-glycoprotein [Arabidopsis ... 548 e-154
gi|27368859|emb|CAD59587.1| MDR-like ABC transporter [Oryza sati... 546 e-154
gi|19032275|dbj|BAB85651.1| multidrug resistance protein 1 homol... 546 e-154
gi|25297456|pir||F86155 probable ABC transporter [imported] - Ar... 545 e-153
gi|39594943|emb|CAE70811.1| Hypothetical protein CBG17574 [Caeno... 545 e-153
gi|15217786|ref|NP_171754.1| multidrug resistance P-glycoprotein... 545 e-153
gi|26449438|dbj|BAC41846.1| putative P-glycoprotein [Arabidopsis... 545 e-153
gi|27368865|emb|CAD59590.1| MDR-like ABC transporter [Oryza sati... 541 e-152
gi|4204793|gb|AAD10836.1| P-glycoprotein [Solanum tuberosum] 540 e-152
gi|14715462|dbj|BAB62040.1| CjMDR1 [Coptis japonica] 539 e-151
gi|27368869|emb|CAD59592.1| MDR-like ABC transporter [Oryza sati... 538 e-151
gi|27368847|emb|CAD59581.1| MDR-like ABC transporter [Oryza sati... 537 e-151
gi|39594940|emb|CAE70808.1| Hypothetical protein CBG17570 [Caeno... 537 e-151
gi|33299999|emb|CAA88940.3| Hypothetical protein DH11.3 [Caenorh... 537 e-151
gi|27368849|emb|CAD59582.1| MDR-like ABC transporter [Oryza sati... 535 e-150
gi|34911450|ref|NP_917072.1| putative multidrug resistance prote... 535 e-150
gi|15228052|ref|NP_181228.1| multidrug resistance P-glycoprotein... 535 e-150
gi|27368855|emb|CAD59585.1| MDR-like ABC transporter [Oryza sati... 535 e-150
gi|50556486|ref|XP_505651.1| hypothetical protein [Yarrowia lipo... 535 e-150
gi|22331385|ref|NP_683599.1| P-glycoprotein, putative [Arabidops... 534 e-150
gi|9294577|dbj|BAB02858.1| multidrug resistance p-glycoprotein; ... 534 e-150
gi|15232978|ref|NP_189480.1| P-glycoprotein, putative [Arabidops... 533 e-149
gi|22655312|gb|AAM98246.1| putative ABC transporter [Arabidopsis... 532 e-149
gi|50732439|ref|XP_418636.1| PREDICTED: similar to Multidrug res... 532 e-149
gi|21740907|emb|CAD40903.1| OSJNBa0036B21.21 [Oryza sativa (japo... 532 e-149
gi|34913530|ref|NP_918112.1| putative multidrug resistance prote... 532 e-149
gi|27368851|emb|CAD59583.1| MDR-like ABC transporter [Oryza sati... 530 e-149
gi|15234322|ref|NP_192091.1| multidrug resistance P-glycoprotein... 530 e-149
gi|25455873|pir||T52319 P-glycoprotein-like protein pgp3 [import... 530 e-149
gi|15234323|ref|NP_192092.1| multidrug resistance P-glycoprotein... 530 e-149
gi|15217809|ref|NP_174122.1| multidrug resistance P-glycoprotein... 530 e-149
gi|7494503|pir||T30855 multidrug resistance protein 2 - fluke (S... 526 e-147
gi|7498268|pir||T20386 hypothetical protein DH11.3 - Caenorhabdi... 525 e-147
gi|17532731|ref|NP_495674.1| P-GlycoProtein related (pgp-11) [Ca... 525 e-147
gi|15217776|ref|NP_174115.1| multidrug resistance P-glycoprotein... 523 e-147
gi|15232977|ref|NP_189479.1| P-glycoprotein, putative [Arabidops... 521 e-146
gi|6671365|gb|AAF23176.1| P-glycoprotein [Gossypium hirsutum] 519 e-145
gi|7493911|pir||T30882 multidrug resistance protein 1 - Aspergil... 518 e-145
gi|34913544|ref|NP_918119.1| putative multidrug resistance prote... 516 e-144
gi|45735908|dbj|BAD12940.1| putative P-glycoprotein 1 [Oryza sat... 516 e-144
gi|22328760|ref|NP_193539.2| ABC transporter family protein [Ara... 513 e-144
gi|25407562|pir||H85202 hypothetical protein AT4g18050 [imported... 513 e-144
gi|15236067|ref|NP_194326.1| multidrug resistance P-glycoprotein... 513 e-144
gi|20466380|gb|AAM20507.1| P-glycoprotein-2 [Arabidopsis thaliana] 512 e-143
gi|39587763|emb|CAE67781.1| Hypothetical protein CBG13356 [Caeno... 511 e-143
gi|38049160|gb|AAR10387.1| P-glycoprotein 1 [Sorghum bicolor] 510 e-143
gi|46390486|dbj|BAD15946.1| putative MDR-like ABC transporter [O... 506 e-141
gi|27368839|emb|CAD59577.1| MDR-like ABC transporter [Oryza sati... 506 e-141
gi|15220188|ref|NP_172538.1| P-glycoprotein, putative [Arabidops... 504 e-141
gi|27368845|emb|CAD59580.1| MDR-like ABC transporter [Oryza sati... 504 e-141
gi|15232975|ref|NP_189477.1| ABC transporter family protein [Ara... 502 e-140
gi|9294571|dbj|BAB02852.1| multidrug resistance p-glycoprotein; ... 502 e-140
gi|7442649|pir||T06165 multidrug resistance protein 1 homolog - ... 501 e-140
gi|49080124|ref|XP_403624.1| hypothetical protein UM06009.1 [Ust... 501 e-140
gi|218550|dbj|BAA01537.1| pmd1 protein [Schizosaccharomyces pombe] 495 e-138
gi|19075765|ref|NP_588265.1| leptomycin b resistance protein, ab... 495 e-138
gi|7494131|pir||T30804 P-glycoprotein 6 - Entamoeba histolytica ... 495 e-138
gi|27368841|emb|CAD59578.1| MDR-like ABC transporter [Oryza sati... 493 e-137
gi|27368861|emb|CAD59588.1| MDR-like ABC transporter [Oryza sati... 493 e-137
gi|46129276|ref|XP_388999.1| hypothetical protein FG08823.1 [Gib... 486 e-135
gi|34910738|ref|NP_916716.1| putative P-glycoprotein [Oryza sati... 485 e-135
gi|27368843|emb|CAD59579.1| MDR-like ABC transporter [Oryza sati... 482 e-134
gi|37806003|dbj|BAC99416.1| putative MDR-like ABC transporter [O... 482 e-134
gi|38098857|gb|AAR11078.1| ATP binding cassette transporter [Lep... 481 e-134
gi|24960750|gb|AAN65444.1| Hypothetical protein [Oryza sativa (j... 478 e-133
gi|25297460|pir||B86240 protein F20B24.12 [imported] - Arabidops... 475 e-132
gi|37695542|gb|AAR00316.1| PGP1; ZMPGP1 [Zea mays] 474 e-132
gi|49089656|ref|XP_406486.1| hypothetical protein AN2349.2 [Aspe... 471 e-131
gi|5456699|gb|AAD43625.1| ATP-binding cassette multidrug transpo... 471 e-131
gi|7442651|pir||T14805 hypothetical protein F15J5.20 - Arabidops... 470 e-131
gi|7508147|pir||T25083 hypothetical protein T21E8.1 - Caenorhabd... 464 e-129
gi|9294508|dbj|BAB02613.1| P-glycoprotein; multi-drug resistance... 462 e-128
gi|7508148|pir||T25082 hypothetical protein T21E8.2 - Caenorhabd... 461 e-128
gi|49092568|ref|XP_407745.1| hypothetical protein AN3608.2 [Aspe... 457 e-127
gi|46114962|ref|XP_383499.1| hypothetical protein FG03323.1 [Gib... 456 e-126
gi|46125007|ref|XP_387057.1| hypothetical protein FG06881.1 [Gib... 455 e-126
gi|4587971|gb|AAD25925.1| ABC transporter protein AtrC [Emericel... 450 e-125
gi|730011|sp|Q06034|MDR1_LEIEN Multidrug resistance protein 1 (P... 449 e-124
gi|2360941|gb|AAB69130.1| P-glycoprotein 445 e-123
gi|46109604|ref|XP_381860.1| hypothetical protein FG01684.1 [Gib... 444 e-123
gi|38099353|gb|EAA46710.1| hypothetical protein MG09931.4 [Magna... 440 e-121
gi|4521245|dbj|BAA76299.1| LAMDR1 [Leishmania mexicana amazonensis] 439 e-121
gi|25990364|gb|AAN76500.1| P-glycoprotein [Homo sapiens] 439 e-121
gi|159363|gb|AAA02977.1| P-glycoprotein 438 e-121
gi|4768949|gb|AAD29692.1| sister of P-glycoprotein [Fundulus het... 435 e-120
gi|191159|gb|AAA37006.1| P-glycoprotein (pgp1) 432 e-119
gi|38108326|gb|EAA54363.1| hypothetical protein MG02348.4 [Magna... 432 e-119
gi|49138261|ref|XP_413479.1| hypothetical protein AN9342.2 [Aspe... 432 e-119
gi|72478|pir||DVHY2C multidrug resistance protein 2 - Chinese ha... 431 e-119
gi|7522025|pir||T30191 multidrug resistance protein 1 - Aureobas... 430 e-118
gi|32402932|ref|XP_322079.1| hypothetical protein [Neurospora cr... 428 e-118
gi|7442650|pir||JG0166 LaMDR1 protein - Leishmania mexicana amaz... 427 e-118
gi|46111809|ref|XP_382962.1| hypothetical protein FG02786.1 [Gib... 424 e-117
gi|49081308|ref|XP_404076.1| hypothetical protein UM06461.1 [Ust... 424 e-117
gi|34935680|ref|XP_234725.2| similar to P-glycoprotein [Rattus n... 422 e-116
gi|20530737|gb|AAM27211.1| multidrug resistance protein 4 [Asper... 416 e-114
gi|42820674|emb|CAF31987.1| ABC transporter, putative [Aspergill... 416 e-114
gi|46116988|ref|XP_384512.1| hypothetical protein FG04336.1 [Gib... 416 e-114
gi|46401536|dbj|BAD16632.1| LAMDR2 [Leishmania amazonensis] 414 e-114
gi|38101651|gb|EAA48581.1| hypothetical protein MG00239.4 [Magna... 411 e-113
gi|191153|gb|AAA37003.1| p-glycoprotein 410 e-113
gi|32418014|ref|XP_329485.1| hypothetical protein [Neurospora cr... 410 e-112
gi|49097828|ref|XP_410374.1| hypothetical protein AN6237.2 [Aspe... 409 e-112
gi|46107316|ref|XP_380717.1| hypothetical protein FG00541.1 [Gib... 405 e-111
gi|47225423|emb|CAG11906.1| unnamed protein product [Tetraodon n... 395 e-108
gi|18033871|gb|AAL57242.1| ATP-binding cassette transporter ABC3... 382 e-104
gi|32400322|dbj|BAC78652.1| ABC transporter [Aspergillus oryzae] 381 e-104
gi|45735909|dbj|BAD12941.1| putative P-glycoprotein 1 [Oryza sat... 371 e-101
gi|18253111|dbj|BAB83959.1| multidrug resistance p-glycoprotein ... 357 1e-96
gi|13346110|gb|AAK19598.1| putative ABC transporter [Sterkiella ... 351 4e-95
gi|45775220|gb|AAK83023.2| truncated P-glycoprotein [Rattus norv... 345 2e-93
gi|17567271|ref|NP_510129.1| P-GlycoProtein related (pgp-15) [Ca... 336 2e-90
gi|1174535|gb|AAA86666.1| ATP-binding cassette protein [Fasciola... 335 3e-90
gi|34525|emb|CAA29547.1| P-glycoprotein (431 AA) [Homo sapiens] 332 4e-89
gi|41052996|dbj|BAD07905.1| putative MDR-like ABC transporter [O... 325 3e-87
gi|47900485|gb|AAT39242.1| putative P-glycoprotein [Oryza sativa... 322 4e-86
gi|22974777|ref|ZP_00020923.1| hypothetical protein [Chloroflexu... 314 8e-84
gi|47218631|emb|CAG04960.1| unnamed protein product [Tetraodon n... 313 1e-83
gi|10241621|emb|CAC09461.1| putative P-glycoprotein [Oryza sativ... 309 3e-82
gi|47225422|emb|CAG11905.1| unnamed protein product [Tetraodon n... 309 3e-82
gi|45735907|dbj|BAD12939.1| putative P-glycoprotein 1 [Oryza sat... 307 7e-82
gi|34851887|ref|XP_341718.1| similar to ABC transporter [Rattus ... 306 1e-81
gi|19698967|gb|AAL91219.1| P-glycoprotein, putative [Arabidopsis... 305 5e-81
gi|9992887|gb|AAG11416.1| TagA [Dictyostelium discoideum] 303 1e-80
gi|18496655|gb|AAL74187.1| putative ABC transporter [Triticum mo... 302 2e-80
gi|7510080|pir||T31617 hypothetical protein Y50E8A.m - Caenorhab... 302 3e-80
gi|19335724|gb|AAL85486.1| transporter associated with antigen p... 302 3e-80
gi|22327455|ref|NP_198720.2| ABC transporter (TAP2) [Arabidopsis... 302 3e-80
gi|17565938|ref|NP_506645.1| HAlF transporter, PGP related (haf-... 302 3e-80
gi|9506367|ref|NP_062425.1| ATP-binding cassette, sub-family B, ... 301 4e-80
gi|12278525|gb|AAG49002.1| putative ABC transporter [Hordeum vul... 301 5e-80
gi|18496654|gb|AAL74186.1| putative ABC transporter [Triticum mo... 301 7e-80
gi|10177549|dbj|BAB10828.1| ABC transporter-like protein [Arabid... 299 2e-79
gi|12061244|gb|AAG45492.1| 36I5.4 [Oryza sativa (japonica cultiv... 298 3e-79
gi|17551158|ref|NP_509205.1| P-GlycoProtein related (pgp-10) [Ca... 298 4e-79
gi|12278526|gb|AAG49003.1| putative ABC transporter [Hordeum vul... 298 4e-79
gi|18496814|gb|AAL74248.1| ABC transporter AbcB1 [Dictyostelium ... 298 4e-79
gi|17543740|ref|NP_502776.1| HAlF transporter, PGP related (haf-... 297 1e-78
gi|39586807|emb|CAE65850.1| Hypothetical protein CBG10984 [Caeno... 296 2e-78
gi|49077780|ref|XP_402711.1| hypothetical protein UM05096.1 [Ust... 295 4e-78
gi|21326114|gb|AAM47580.1| putative ABC-transporter-like protein... 293 1e-77
gi|39583384|emb|CAE66359.1| Hypothetical protein CBG11616 [Caeno... 293 2e-77
gi|32966961|gb|AAP92331.1| multixenobiotic resistance protein [C... 292 3e-77
gi|18875456|gb|AAL74251.2| ABC transporter AbcB4 [Dictyostelium ... 287 1e-75
gi|39581765|emb|CAE74138.1| Hypothetical protein CBG21809 [Caeno... 285 4e-75
gi|27368853|emb|CAD59584.1| MDR-like ABC transporter [Oryza sati... 285 5e-75
gi|34906082|ref|NP_914388.1| putative P-glycoprotein [Oryza sati... 285 5e-75
gi|40787796|gb|AAH64930.1| ATP-binding cassette, sub-family B, m... 284 9e-75
gi|20453064|gb|AAM19777.1| At2g39480/F12L6.14 [Arabidopsis thali... 282 3e-74
gi|15225474|ref|NP_181480.1| ABC transporter family protein [Ara... 282 3e-74
gi|31216972|ref|XP_316337.1| ENSANGP00000013796 [Anopheles gambi... 281 4e-74
gi|9961244|ref|NP_036221.1| ATP-binding cassette, sub-family B, ... 281 6e-74
gi|15233244|ref|NP_191092.1| ABC transporter family protein [Ara... 280 1e-73
gi|24641565|ref|NP_572810.1| CG1824-PA [Drosophila melanogaster]... 279 3e-73
gi|50877523|emb|CAG37363.1| related to ABC-transporter, ATP-bind... 278 4e-73
gi|48892154|ref|ZP_00325566.1| COG1132: ABC-type multidrug trans... 277 8e-73
gi|47217174|emb|CAG11010.1| unnamed protein product [Tetraodon n... 276 1e-72
gi|39997358|ref|NP_953309.1| ABC transporter, ATP-binding protei... 276 1e-72
gi|2147880|pir||I48120 P-glycoprotein - Chinese hamster (fragmen... 275 3e-72
gi|12248755|dbj|BAB20265.1| mono ATP-binding cassette protein [H... 273 2e-71
gi|31206493|ref|XP_312209.1| ENSANGP00000002692 [Anopheles gambi... 272 3e-71
gi|1743406|emb|CAB05918.1| transport-associated protein [Salmo s... 271 5e-71
gi|21230937|ref|NP_636854.1| ABC transporter ATP-binding protein... 271 8e-71
gi|2119779|pir||S50217 multidrug resistance protein 3 - rat (fra... 271 8e-71
gi|39580953|emb|CAE72923.1| Hypothetical protein CBG20243 [Caeno... 269 2e-70
gi|2147879|pir||I48119 P-glycoprotein - Chinese hamster (fragmen... 268 4e-70
gi|48844191|ref|ZP_00298519.1| COG1132: ABC-type multidrug trans... 267 9e-70
gi|21242281|ref|NP_641863.1| ABC transporter ATP-binding protein... 267 1e-69
gi|28900647|ref|NP_800302.1| putative ATP-binding/permease fusio... 267 1e-69
gi|23016084|ref|ZP_00055844.1| COG1132: ABC-type multidrug trans... 266 1e-69
gi|7511165|pir||T32865 hypothetical protein ZK484.2 - Caenorhabd... 266 2e-69
gi|17511077|ref|NP_491754.1| HAlF transporter, PGP related (90.8... 266 2e-69
gi|5823088|gb|AAD53035.1| TAP2B protein [Oncorhynchus mykiss] 266 2e-69
gi|39582351|emb|CAE67600.1| Hypothetical protein CBG13145 [Caeno... 265 3e-69
gi|27366635|ref|NP_762162.1| ABC-type multidrug transport system... 265 4e-69
gi|17533971|ref|NP_495537.1| HAlF transporter, PGP related (haf-... 265 6e-69
gi|46119497|ref|ZP_00176704.2| COG1132: ABC-type multidrug trans... 264 9e-69
gi|37676347|ref|NP_936743.1| ABC-type multidrug transport system... 263 2e-68
gi|27753995|ref|NP_083296.2| RIKEN cDNA 4833412N02 [Mus musculus... 262 4e-68
gi|26339816|dbj|BAC33571.1| unnamed protein product [Mus musculus] 262 4e-68
gi|15966528|ref|NP_386881.1| PROBABLE ABC TRANSPORTER ATP-BINDIN... 261 6e-68
gi|49476161|ref|YP_034202.1| ABC transporter, ATP-binding protei... 261 6e-68
gi|47212418|emb|CAG12367.1| unnamed protein product [Tetraodon n... 261 8e-68
gi|48730042|ref|ZP_00263791.1| COG1132: ABC-type multidrug trans... 261 8e-68
gi|5911322|gb|AAD55751.1| transporter associated with antigen pr... 261 8e-68
gi|22298505|ref|NP_681752.1| ABC transporter ATP-binding protein... 260 1e-67
gi|34853987|ref|XP_342615.1| similar to RIKEN cDNA 4833412N02 [R... 260 1e-67
gi|27452581|gb|AAN71739.1| ABCB9-like TAP-family protein [Petrom... 260 1e-67
gi|26345292|dbj|BAC36297.1| unnamed protein product [Mus musculus] 259 2e-67
gi|48864170|ref|ZP_00318063.1| COG1132: ABC-type multidrug trans... 259 2e-67
gi|49474685|ref|YP_032727.1| ABC transporter, ATP-binding protei... 258 4e-67
gi|22095457|sp|Q9JJ59|ABC9_MOUSE ATP-binding cassette, sub-famil... 258 4e-67
gi|26006275|dbj|BAC41480.1| mKIAA1520 protein [Mus musculus] 258 4e-67
gi|9845230|ref|NP_063928.1| ATP-binding cassette, sub-family B, ... 258 5e-67
gi|18124194|gb|AAL59859.1| transporter associated with antigen p... 258 5e-67
gi|9955966|ref|NP_062571.1| ATP-binding cassette, sub-family B (... 258 7e-67
gi|11560034|ref|NP_071574.1| TAP-like ABC transporter [Rattus no... 258 7e-67
gi|15891205|ref|NP_356877.1| AGR_L_2179p [Agrobacterium tumefaci... 258 7e-67
gi|23104911|ref|ZP_00091371.1| COG1132: ABC-type multidrug trans... 258 7e-67
gi|46916508|emb|CAG23273.1| putative ATP-binding/permease fusion... 257 9e-67
gi|23475242|ref|ZP_00130531.1| COG1132: ABC-type multidrug trans... 257 9e-67
gi|15808008|ref|NP_285672.1| ABC transporter, ATP-binding protei... 257 9e-67
gi|5911326|gb|AAD55753.1| transporter associated with antigen pr... 257 1e-66
gi|5823084|gb|AAD53033.1| TAP1 protein [Oncorhynchus mykiss] 257 1e-66
gi|37521898|ref|NP_925275.1| HlyB/MsbA family ABC transporter [G... 257 1e-66
gi|50741416|ref|XP_419578.1| PREDICTED: similar to ATP-binding c... 257 1e-66
gi|8176565|dbj|BAA96370.1| ABC protein [Physarum polycephalum] 256 2e-66
gi|22959359|ref|ZP_00007012.1| COG1132: ABC-type multidrug trans... 256 2e-66
gi|1743404|emb|CAB05917.1| transport-associated protein [Salmo s... 256 2e-66
gi|15890388|ref|NP_356060.1| AGR_L_552p [Agrobacterium tumefacie... 255 3e-66
gi|13473363|ref|NP_104930.1| ABC transporter, ATP-binding protei... 255 4e-66
gi|17228136|ref|NP_484684.1| ATP-binding protein of ABC transpor... 254 6e-66
gi|7023646|dbj|BAA92038.1| unnamed protein product [Homo sapiens] 254 6e-66
gi|45548045|ref|ZP_00188081.1| COG1132: ABC-type multidrug trans... 254 6e-66
gi|23469088|ref|ZP_00124423.1| COG1132: ABC-type multidrug trans... 254 7e-66
gi|29561855|emb|CAD87788.1| SI:dZ262K18.3 (ATP-binding cassette,... 254 1e-65
gi|45506769|ref|ZP_00159120.1| COG1132: ABC-type multidrug trans... 253 1e-65
gi|21673056|ref|NP_661121.1| ABC transporter, ATP-binding protei... 253 1e-65
gi|8176563|dbj|BAA96369.1| ABC protein [Physarum polycephalum] 253 2e-65
gi|45916934|ref|ZP_00195995.2| COG1132: ABC-type multidrug trans... 253 2e-65
gi|16330165|ref|NP_440893.1| ABC transporter [Synechocystis sp. ... 253 2e-65
gi|23127899|ref|ZP_00109758.1| COG1132: ABC-type multidrug trans... 253 2e-65
gi|28199828|ref|NP_780142.1| ABC transporter ATP-binding protein... 252 3e-65
gi|39992420|gb|AAH64384.1| ABCB9 protein [Homo sapiens] 252 3e-65
gi|6005804|ref|NP_009119.1| ATP-binding cassette, sub-family B, ... 251 5e-65
gi|13123950|sp|Q9NUT2|ABC8_HUMAN ATP-binding cassette, sub-famil... 251 5e-65
gi|47575345|ref|ZP_00245380.1| COG1132: ABC-type multidrug trans... 251 5e-65
gi|48850584|ref|ZP_00304826.1| COG1132: ABC-type multidrug trans... 251 5e-65
gi|27376619|ref|NP_768148.1| HlyB/MsbA family ABC transporter [B... 251 5e-65
gi|47225421|emb|CAG11904.1| unnamed protein product [Tetraodon n... 251 5e-65
gi|22997178|ref|ZP_00041414.1| COG1132: ABC-type multidrug trans... 251 6e-65
gi|39579434|emb|CAE74830.1| Hypothetical protein CBG22668 [Caeno... 251 6e-65
gi|24374337|ref|NP_718380.1| ABC transporter, ATP-binding protei... 250 1e-64
gi|23127765|ref|ZP_00109628.1| COG1132: ABC-type multidrug trans... 250 1e-64
gi|47077792|dbj|BAD18770.1| unnamed protein product [Homo sapiens] 250 1e-64
gi|39933996|ref|NP_946272.1| ABC transporter, ATP-binding protei... 250 1e-64
gi|28379465|ref|NP_786357.1| ABC transporter, ATP-binding protei... 250 1e-64
gi|21753735|dbj|BAC04392.1| unnamed protein product [Homo sapiens] 249 2e-64
gi|23397593|ref|NP_569844.2| CG3156-PA [Drosophila melanogaster]... 249 2e-64
gi|17232685|ref|NP_489233.1| ATP-binding protein of ABC transpor... 249 2e-64
gi|5733401|gb|AAD49563.1| P-glycoprotein-like protein [Onchocerc... 249 2e-64
gi|30249744|ref|NP_841814.1| ABC transporter, fused permease and... 249 2e-64
gi|2492605|sp|P97998|MDL1_CANAL ATP-dependent permease MDL1 >gnl... 249 3e-64
gi|16264301|ref|NP_437093.1| putative lipid A + LPS core exporti... 249 3e-64
gi|46440040|gb|EAK99351.1| hypothetical protein CaO19.2615 [Cand... 248 4e-64
gi|45916645|ref|ZP_00197576.1| COG1132: ABC-type multidrug trans... 248 4e-64
gi|525293|emb|CAA53758.1| PGP1 [Trichomonas vaginalis] 248 4e-64
gi|15672293|ref|NP_266467.1| ABC transporter ATP binding and per... 248 5e-64
gi|48855938|ref|ZP_00310096.1| COG1132: ABC-type multidrug trans... 248 7e-64
gi|22995060|ref|ZP_00039543.1| COG1132: ABC-type multidrug trans... 248 7e-64
gi|28869225|ref|NP_791844.1| ABC transporter, ATP-binding/permea... 248 7e-64
gi|28210179|ref|NP_781123.1| multidrug resistance ABC transporte... 247 9e-64
gi|37781028|gb|AAP36720.1| transporter associated with antigen p... 247 9e-64
gi|46134905|ref|ZP_00158883.2| COG1132: ABC-type multidrug trans... 247 1e-63
gi|48833973|ref|ZP_00290989.1| COG1132: ABC-type multidrug trans... 246 2e-63
gi|46580081|ref|YP_010889.1| ABC transporter, ATP-binding protei... 246 2e-63
gi|33863091|ref|NP_894651.1| ABC transporter, possibly multidrug... 246 3e-63
gi|16078496|ref|NP_389315.1| yknU [Bacillus subtilis subsp. subt... 246 3e-63
gi|23502573|ref|NP_698700.1| ABC transporter, ATP binding/permea... 246 3e-63
gi|1743408|emb|CAB05919.1| transport-associated protein [Salmo s... 245 3e-63
gi|46141086|ref|ZP_00203861.1| COG1132: ABC-type multidrug trans... 245 3e-63
gi|7445902|pir||T13416 hypothetical protein 171D11.2 - fruit fly... 245 5e-63
gi|48824040|ref|ZP_00285472.1| COG1132: ABC-type multidrug trans... 245 5e-63
gi|16127504|ref|NP_422068.1| ABC transporter, HlyB/MsbA family [... 245 5e-63
gi|15963913|ref|NP_384266.1| PUTATIVE ATP-BINDING ABC TRANSPORTE... 244 6e-63
gi|33636348|dbj|BAC81752.1| hydrophobic compound transport facto... 244 6e-63
gi|37521765|ref|NP_925142.1| HlyB/MsbA family ABC transporter [G... 244 6e-63
gi|15839171|ref|NP_299859.1| ABC transporter ATP-binding protein... 244 6e-63
gi|1016270|gb|AAA79094.1| p-glycoprotein 244 8e-63
gi|15596310|ref|NP_249804.1| probable ATP-binding/permease fusio... 244 8e-63
gi|32041123|ref|ZP_00138706.1| COG1132: ABC-type multidrug trans... 244 8e-63
gi|17986606|ref|NP_539240.1| PROBABLE TRANSPORT ATP-BINDING PROT... 244 1e-62
gi|26988843|ref|NP_744268.1| ABC efflux transporter, permease/AT... 244 1e-62
gi|34496280|ref|NP_900495.1| transport ATP-binding protein msbA ... 243 1e-62
gi|39579610|emb|CAE56497.1| Hypothetical protein CBG24214 [Caeno... 243 2e-62
gi|46130296|ref|ZP_00165119.2| COG1132: ABC-type multidrug trans... 243 2e-62
gi|27468468|ref|NP_765105.1| ABC transporter (ATP-binding protei... 243 2e-62
gi|16330032|ref|NP_440760.1| ABC transporter [Synechocystis sp. ... 243 2e-62
gi|46115926|ref|XP_383981.1| hypothetical protein FG03805.1 [Gib... 243 2e-62
gi|27365418|ref|NP_760946.1| Transport ATP-binding protein MsbA ... 242 3e-62
gi|23336111|ref|ZP_00121339.1| COG1132: ABC-type multidrug trans... 242 3e-62
gi|37680540|ref|NP_935149.1| transport ATP-binding protein MsbA ... 241 5e-62
gi|16124560|ref|NP_419124.1| ABC transporter, HlyB/MsbA family [... 241 5e-62
gi|30686893|ref|NP_194275.2| ABC transporter family protein [Ara... 241 5e-62
gi|39936328|ref|NP_948604.1| putative ABC transporter [Rhodopseu... 241 7e-62
gi|48771097|ref|ZP_00275440.1| COG1132: ABC-type multidrug trans... 241 7e-62
gi|34901502|ref|NP_912097.1| contains ESTs C74558(E31852),AU0948... 241 7e-62
gi|29348795|ref|NP_812298.1| ABC transporter, ATP-binding protei... 241 7e-62
gi|48826439|ref|ZP_00287643.1| COG1132: ABC-type multidrug trans... 241 7e-62
gi|23002311|ref|ZP_00045988.1| COG1132: ABC-type multidrug trans... 241 9e-62
gi|50085455|ref|YP_046965.1| lipid transport protein, flippase (... 240 1e-61
gi|28211454|ref|NP_782398.1| multidrug resistance ABC transporte... 240 1e-61
gi|46308813|ref|ZP_00211005.1| COG1132: ABC-type multidrug trans... 240 1e-61
gi|49475315|ref|YP_033356.1| ABC transporter, ATP-binding protei... 240 1e-61
gi|23024543|ref|ZP_00063750.1| COG1132: ABC-type multidrug trans... 240 1e-61
gi|50551833|ref|XP_503391.1| hypothetical protein [Yarrowia lipo... 239 2e-61
gi|29375380|ref|NP_814534.1| ABC transporter, ATP-binding/permea... 239 3e-61
gi|23127335|ref|ZP_00109208.1| COG1132: ABC-type multidrug trans... 238 4e-61
gi|23098860|ref|NP_692326.1| ABC transporter ATP-binding protein... 238 4e-61
gi|15924856|ref|NP_372390.1| ABC transporter homolog [Staphyloco... 238 6e-61
gi|50304659|ref|XP_452285.1| unnamed protein product [Kluyveromy... 238 6e-61
gi|30248923|ref|NP_840993.1| ABC transporter, fused permease and... 238 6e-61
gi|22970612|ref|ZP_00017667.1| hypothetical protein [Chloroflexu... 238 6e-61
gi|15894891|ref|NP_348240.1| ABC-type multidrug/protein/lipid tr... 238 7e-61
gi|31194451|ref|XP_306173.1| ENSANGP00000015516 [Anopheles gambi... 238 7e-61
gi|49477449|ref|YP_036121.1| multidrug resistance ABC transporte... 238 7e-61
gi|45521342|ref|ZP_00172862.1| COG1132: ABC-type multidrug trans... 238 7e-61
gi|17988594|ref|NP_541227.1| ABC TRANSPORTER ATP-BINDING PROTEIN... 237 9e-61
gi|23100898|ref|NP_694365.1| ABC transporter ATP-binding protein... 237 9e-61
gi|33602558|ref|NP_890118.1| putative ABC transporter [Bordetell... 237 1e-60
gi|17229638|ref|NP_486186.1| ATP-binding protein of ABC transpor... 237 1e-60
gi|23500772|ref|NP_700212.1| ABC transporter, ATP-binding/permea... 236 2e-60
gi|50510160|dbj|BAD31127.1| putative ATP-binding cassette, sub-f... 236 2e-60
gi|42781108|ref|NP_978355.1| ABC transporter, ATP-binding/permea... 236 2e-60
gi|15600190|ref|NP_253684.1| transport protein MsbA [Pseudomonas... 236 2e-60
gi|46319843|ref|ZP_00220241.1| COG1132: ABC-type multidrug trans... 236 2e-60
gi|24375163|ref|NP_719206.1| ABC transporter, ATP-binding/permea... 236 2e-60
gi|21622336|emb|CAD36977.1| probable multidrug resistance protei... 236 2e-60
gi|50590097|ref|ZP_00331525.1| COG1132: ABC-type multidrug trans... 236 2e-60
gi|46311693|ref|ZP_00212296.1| COG1132: ABC-type multidrug trans... 236 2e-60
gi|17232691|ref|NP_489239.1| ATP-binding protein of ABC transpor... 236 3e-60
gi|16077889|ref|NP_388703.1| yfiC [Bacillus subtilis subsp. subt... 236 3e-60
gi|49473726|ref|YP_031768.1| ABC transporter, ATP-binding protei... 236 3e-60
gi|42518673|ref|NP_964603.1| ABC transporter ATPase and permease... 236 3e-60
gi|50590389|ref|ZP_00331775.1| COG1132: ABC-type multidrug trans... 236 3e-60
gi|19112543|ref|NP_595751.1| putative permease [Schizosaccharomy... 235 4e-60
gi|15643057|ref|NP_228100.1| ABC transporter, ATP-binding protei... 235 4e-60
gi|16519755|ref|NP_443875.1| Y4gM [Rhizobium sp. NGR234] >gnl|BL... 235 4e-60
gi|23102360|ref|ZP_00088871.1| COG5265: ABC-type transport syste... 235 4e-60
gi|15674418|ref|NP_268592.1| putative ABC transporter (ATP-bindi... 235 5e-60
gi|22971761|ref|ZP_00018689.1| hypothetical protein [Chloroflexu... 235 5e-60
gi|33602079|ref|NP_889639.1| ABC transporter, ATP-binding protei... 235 5e-60
gi|13476485|ref|NP_108055.1| ABC transporter, ATP-binding protei... 235 5e-60
gi|45656478|ref|YP_000564.1| ABC transporter, atp-binding protei... 235 5e-60
gi|16552593|dbj|BAB71347.1| unnamed protein product [Homo sapiens] 234 6e-60
gi|49474872|ref|YP_032913.1| ABC transporter, ATP-binding protei... 234 6e-60
gi|3387977|gb|AAC28653.1| ABC transporter [Homo sapiens] 234 6e-60
gi|17230327|ref|NP_486875.1| ATP-binding protein; heterocyst dif... 234 6e-60
gi|15641880|ref|NP_231512.1| transport ATP-binding protein MsbA ... 234 6e-60
gi|11245444|gb|AAG33617.1| ATP-binding cassette half-transporter... 234 6e-60
gi|9955963|ref|NP_005680.1| ATP-binding cassette, sub-family B, ... 234 6e-60
gi|33592061|ref|NP_879705.1| ABC transporter, ATP-binding protei... 234 6e-60
gi|24216329|ref|NP_713810.1| Probable transport ATP-binding prot... 234 8e-60
gi|33597710|ref|NP_885353.1| putative ABC transporter [Bordetell... 234 8e-60
gi|23467052|ref|ZP_00122637.1| COG1132: ABC-type multidrug trans... 234 8e-60
gi|47572829|ref|ZP_00242870.1| COG1132: ABC-type multidrug trans... 234 8e-60
gi|27452473|gb|AAN71740.1| ABCB9-like TAP-family protein [Petrom... 234 8e-60
gi|29654183|ref|NP_819875.1| ABC transporter, ATP-binding/permea... 234 8e-60
gi|33596261|ref|NP_883904.1| ABC transporter, ATP-binding protei... 234 8e-60
gi|7445810|pir||S72638 hypothetical ABC exporter component B - T... 234 8e-60
gi|21909700|ref|NP_663968.1| putative ABC transporter ATP-bindin... 234 1e-59
gi|42527766|ref|NP_972864.1| ABC transporter, ATP-binding/permea... 234 1e-59
gi|48835452|ref|ZP_00292452.1| COG1132: ABC-type multidrug trans... 233 1e-59
gi|26246941|ref|NP_752981.1| Probable transport ATP-binding prot... 233 1e-59
gi|30519701|emb|CAD90041.1| putative ATP-binding cassette transp... 233 1e-59
gi|15888407|ref|NP_354088.1| AGR_C_1966p [Agrobacterium tumefaci... 233 2e-59
gi|15800775|ref|NP_286789.1| ATP-binding transport protein; mult... 233 2e-59
gi|47569984|ref|ZP_00240647.1| multidrug resistance ABC transpor... 233 2e-59
gi|17934971|ref|NP_531761.1| ABC transporter, nucleotide binding... 233 2e-59
gi|26788068|emb|CAD58764.1| SI:dZ179B20.3 (novel protein similar... 233 2e-59
gi|17647117|ref|NP_076221.1| ATP-binding cassette, sub-family B ... 233 2e-59
gi|17987775|ref|NP_540409.1| HEAVY METAL TOLERANCE PROTEIN PRECU... 233 2e-59
gi|23501343|ref|NP_697470.1| ABC transporter, ATP-binding/permea... 233 2e-59
gi|17561534|ref|NP_506927.1| HAlF transporter, PGP related (haf-... 232 3e-59
gi|28872098|ref|NP_794717.1| lipid A ABC transporter, ATP-bindin... 232 3e-59
gi|46396386|sp|Q87VF3|MSBA_PSESM Lipid A export ATP-binding/perm... 232 3e-59
gi|27381043|ref|NP_772572.1| ABC transporter HlyB/MsbA family [B... 232 3e-59
gi|37523704|ref|NP_927081.1| HlyB/MsbA family ABC transporter [G... 232 3e-59
gi|30020094|ref|NP_831725.1| Multidrug resistance ABC transporte... 232 3e-59
gi|42520276|ref|NP_966191.1| ABC transporter, HlyB/MsbA family, ... 232 3e-59
gi|19745369|ref|NP_606505.1| putative ABC transporter (ATP-bindi... 232 4e-59
gi|33861384|ref|NP_892945.1| ABC transporter, possibly multidrug... 231 5e-59
gi|2232172|gb|AAB62237.1| TAP2 [Oncorhynchus mykiss] 231 5e-59
gi|7486813|pir||T05802 hypothetical protein M7J2.180 - Arabidops... 231 5e-59
gi|20808867|ref|NP_624038.1| ABC-type multidrug/protein/lipid tr... 231 5e-59
gi|50259844|gb|EAL22512.1| hypothetical protein CNBB3900 [Crypto... 231 7e-59
gi|22971760|ref|ZP_00018688.1| hypothetical protein [Chloroflexu... 231 7e-59
gi|16121675|ref|NP_404988.1| probable transport ATP-binding prot... 231 7e-59
>gi|17569143|ref|NP_509901.1| P-GlycoProtein related (pgp-3)
[Caenorhabditis elegans]
gi|29429184|sp|P34713|MDR3_CAEEL Multidrug resistance protein 3
(P-glycoprotein C)
gi|7511155|pir||T22094 hypothetical protein ZK455.7 - Caenorhabditis
elegans
gi|3877009|emb|CAA91467.1| Hypothetical protein ZK455.7
[Caenorhabditis elegans]
gi|3881645|emb|CAA91495.1| C. elegans PGP-3 protein (corresponding
sequence ZK455.7) [Caenorhabditis elegans]
Length = 1268
Score = 1614 bits (4179), Expect = 0.0
Identities = 835/879 (94%), Positives = 835/879 (94%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW
Sbjct: 390 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 449
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG
Sbjct: 450 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 509
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI
Sbjct: 510 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 569
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERA
Sbjct: 570 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAKEDTTLDDEE 629
Query: 722 XXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXXXXGA 901
HRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVP GA
Sbjct: 630 DEKTHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPEWEIENAREEMIEEGA 689
Query: 902 MEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALL 1081
MEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALL
Sbjct: 690 MEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALL 749
Query: 1082 NSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSL 1261
NSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSL
Sbjct: 750 NSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSL 809
Query: 1262 TSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXXX 1441
TSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIG
Sbjct: 810 TSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGLATALLLVVVQSS 869
Query: 1442 XXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVR 1621
YLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVR
Sbjct: 870 VAQYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVR 929
Query: 1622 GLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAASY 1801
GLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAASY
Sbjct: 930 GLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAASY 989
Query: 1802 FPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVLDG 1981
FPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVLDG
Sbjct: 990 FPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVLDG 1049
Query: 1982 FNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIAL 2161
FNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIAL
Sbjct: 1050 FNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIAL 1109
Query: 2162 VGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRLS 2341
VGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRLS
Sbjct: 1110 VGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRLS 1169
Query: 2342 GGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTI 2521
GGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTI
Sbjct: 1170 GGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTI 1229
Query: 2522 QNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
QNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS
Sbjct: 1230 QNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 1268
Score = 301 bits (771), Expect = 5e-80
Identities = 191/592 (32%), Positives = 304/592 (51%), Gaps = 16/592 (2%)
Frame = +2
Query: 905 EASLFDIFKYASPEMRNIII---SLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKA 1075
+ + FD+F+ A + ++ I+ L+ + + G P S+++ + L G
Sbjct: 28 QGNFFDVFRDA--DYKDYILFSGGLILSAVNGALVPFNSLIFEGIANALMEGESQYQ-NG 84
Query: 1076 LLNSLWF-------ILLAFTGGISTLISGSLLGKAGETMSGR----LRMDVFRNIMQQDA 1222
+N WF L F G++ + T+ R +R +++++QDA
Sbjct: 85 TINMPWFSSEIKMFCLRYFYLGVALFLCSYFANSCLYTLCERRLHCIRKKYLKSVLRQDA 144
Query: 1223 SYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIG 1402
+FD++ +G LT ++++ ++ I ++ ++ G+ + GV + FY W + +
Sbjct: 145 KWFDET--TIGGLTQKMSSGIEKIKDGIGDKVGVLVGGVATFISGVSIGFYMCWQLTLVM 202
Query: 1403 XXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFT 1582
+L + +M + A + E I+ +TV A Q + + +
Sbjct: 203 MITVPLQLGSMYLSAKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYA 262
Query: 1583 AASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEAL 1762
R I + + ++ A + A+A+ +G L + + VF V A+
Sbjct: 263 HQLNEARRMGIRKAIILAICTAFPLMLMFTCMAVAFWYGATLAAAGAVSSGAVFAVFWAV 322
Query: 1763 NMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVY 1939
+ + + AA + AR++ +F +I + I G P I+G + G+
Sbjct: 323 LIGTRRLGEAAPHLGAITGARLAIHDIFKVIDHEPEIKCTSSEGKIPEKIQGKLTFDGIE 382
Query: 1940 FAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDI 2119
F YP R +L G + N G+TVALVG SGCGKST+I L+ R+Y+ G +K+D I
Sbjct: 383 FTYPTRPELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPI 442
Query: 2120 RDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPD 2299
++ +++ LR I +V QEP +F T+ ENI G IT +E+A +AN H F+ L D
Sbjct: 443 QEYNIRWLRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSD 502
Query: 2300 GYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARL 2479
YDT +GA +LSGGQKQRVAIARAIVR P+ILLLDEATSALDTESE++VQ ALDKA
Sbjct: 503 RYDTVIGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASE 562
Query: 2480 GRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLAR-RGLYYRLVEKQ 2632
GRT + IAHRLSTI+NA KI+V G E GTH L+++ G+Y +V+ Q
Sbjct: 563 GRTTLCIAHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ 614
>gi|283552|pir||S27338 P-glycoprotein C - Caenorhabditis elegans
gi|6811|emb|CAA46191.1| P-glycoprotein C [Caenorhabditis elegans]
Length = 1254
Score = 1578 bits (4085), Expect = 0.0
Identities = 821/879 (93%), Positives = 821/879 (93%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW
Sbjct: 390 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 449
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG
Sbjct: 450 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 509
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI
Sbjct: 510 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 569
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
AHRLSTIRNAS THDELISKDDGIYASMVKAQEIERA
Sbjct: 570 AHRLSTIRNAS--------------THDELISKDDGIYASMVKAQEIERAKEDTTLDDEE 615
Query: 722 XXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXXXXGA 901
HRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVP GA
Sbjct: 616 DEKTHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPEWEIENAREEMIEEGA 675
Query: 902 MEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALL 1081
MEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALL
Sbjct: 676 MEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALL 735
Query: 1082 NSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSL 1261
NSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSL
Sbjct: 736 NSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSL 795
Query: 1262 TSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXXX 1441
TSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIG
Sbjct: 796 TSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGLATELLLVVVQSS 855
Query: 1442 XXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVR 1621
YLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVR
Sbjct: 856 VAQYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVR 915
Query: 1622 GLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAASY 1801
GLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAASY
Sbjct: 916 GLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAASY 975
Query: 1802 FPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVLDG 1981
FPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVLDG
Sbjct: 976 FPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVLDG 1035
Query: 1982 FNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIAL 2161
FNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIAL
Sbjct: 1036 FNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIAL 1095
Query: 2162 VGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRLS 2341
VGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRLS
Sbjct: 1096 VGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRLS 1155
Query: 2342 GGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTI 2521
GGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTI
Sbjct: 1156 GGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTI 1215
Query: 2522 QNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
QNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS
Sbjct: 1216 QNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 1254
Score = 282 bits (722), Expect = 3e-74
Identities = 185/592 (31%), Positives = 297/592 (49%), Gaps = 16/592 (2%)
Frame = +2
Query: 905 EASLFDIFKYASPEMRNIII---SLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKA 1075
+ + FD+F+ A + ++ I+ L+ + + G P S+++ + L G
Sbjct: 28 QGNFFDVFRDA--DYKDYILFSGGLILSAVNGALVPFNSLIFEGIANALMEGESQYQ-NG 84
Query: 1076 LLNSLWF-------ILLAFTGGISTLISGSLLGKAGETMSGR----LRMDVFRNIMQQDA 1222
+N WF L F G++ + T+ R +R +++++QDA
Sbjct: 85 TINMPWFSSEIKMFCLRYFYLGVALFLCSYFANSCLYTLCERRLHCIRKKYLKSVLRQDA 144
Query: 1223 SYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIG 1402
+FD++ +G LT ++++ ++ I ++ ++ G+ + GV + FY W + +
Sbjct: 145 KWFDET--TIGGLTQKMSSGIEKIKDGIGDKVGVLVGGVATFISGVSIGFYMCWQLTLVM 202
Query: 1403 XXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFT 1582
+L + +M + A + E I+ +TV A Q + + +
Sbjct: 203 MITVPLQLGSMYLSAKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYA 262
Query: 1583 AASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEAL 1762
R I + + ++ A + A+A+ +G L + + VF V A+
Sbjct: 263 HQLNEARRMGIRKAIILAICTAFPLMLMFTCMAVAFWYGATLAAAGAVSSGAVFAVFWAV 322
Query: 1763 NMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVY 1939
+ + + AA + AR++ +F +I + I G P I+G + G+
Sbjct: 323 LIGTRRLGEAAPHLGAITGARLAIHDIFKVIDHEPEIKCTSSEGKIPEKIQGKLTFDGIE 382
Query: 1940 FAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDI 2119
F YP R +L G + N G+TVALVG SGCGKST+I L+ R+Y+ G +K+D I
Sbjct: 383 FTYPTRPELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPI 442
Query: 2120 RDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPD 2299
++ +++ LR I +V QEP +F T+ ENI G IT +E+A +AN H F+ L D
Sbjct: 443 QEYNIRWLRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSD 502
Query: 2300 GYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARL 2479
YDT +GA +LSGGQKQRVAIARAIVR P+ILLLDEATSALDTESE++VQ ALDKA
Sbjct: 503 RYDTVIGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASE 562
Query: 2480 GRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLAR-RGLYYRLVEKQ 2632
GRT + IAHRLSTI+NA TH L+++ G+Y +V+ Q
Sbjct: 563 GRTTLCIAHRLSTIRNA--------------STHDELISKDDGIYASMVKAQ 600
>gi|39594784|emb|CAE70652.1| Hypothetical protein CBG17357
[Caenorhabditis briggsae]
Length = 1268
Score = 1514 bits (3921), Expect = 0.0
Identities = 776/879 (88%), Positives = 810/879 (91%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
+LKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQ AGMIKLDG+PI EYNIRW
Sbjct: 390 DLKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQGAGMIKLDGVPIHEYNIRW 449
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LRSTIGIVQQEPIIFVATVAENIRMGD LITD DIEEAC+MANAHEFICKLSD+Y+TVIG
Sbjct: 450 LRSTIGIVQQEPIIFVATVAENIRMGDDLITDDDIEEACRMANAHEFICKLSDKYNTVIG 509
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
AGAVQLSGGQKQRVAIARAIVR+PQILLLDEATSALDTESERMVQ ALDKAS+GRTTLCI
Sbjct: 510 AGAVQLSGGQKQRVAIARAIVRRPQILLLDEATSALDTESERMVQAALDKASKGRTTLCI 569
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
AHRLSTI+NASKILVFDQGLIAERGTHDELISK+DGIYASMV AQEIERA
Sbjct: 570 AHRLSTIKNASKILVFDQGLIAERGTHDELISKEDGIYASMVAAQEIERAKEDTTLDDEE 629
Query: 722 XXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXXXXGA 901
HR FHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVP GA
Sbjct: 630 DEKDHRMFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPEWEIESAREEMIEEGA 689
Query: 902 MEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALL 1081
MEASL DIFK+ASPE RNIII+LVFTLIRG TWPAFSIVYGQLF+ILSAGGDDVSIKALL
Sbjct: 690 MEASLVDIFKFASPEGRNIIIALVFTLIRGLTWPAFSIVYGQLFRILSAGGDDVSIKALL 749
Query: 1082 NSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSL 1261
NSLWF+LLAFT GISTL+SG LLGKAGETMSGRLRMDVFRNIMQQDASYFDD +HNVG+L
Sbjct: 750 NSLWFLLLAFTSGISTLVSGGLLGKAGETMSGRLRMDVFRNIMQQDASYFDDPKHNVGAL 809
Query: 1262 TSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXXX 1441
TSRLATDAPNVQAAIDQRLAEVLTG+VSLFCGV VAF+YGWNMAPIG
Sbjct: 810 TSRLATDAPNVQAAIDQRLAEVLTGVVSLFCGVSVAFFYGWNMAPIGLATALLLVVVQSA 869
Query: 1442 XXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVR 1621
YLKFRGQRDMDSAIEASRLVTESISNWKTVQ+LTKQEYMYD+F AASKSPHRRAIVR
Sbjct: 870 VAQYLKFRGQRDMDSAIEASRLVTESISNWKTVQSLTKQEYMYDSFVAASKSPHRRAIVR 929
Query: 1622 GLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAASY 1801
GLWQSLSFALAGSFVMWNFAIAYMFGLWLISN WSTPYTVFQVIEALNMASMSVMLAASY
Sbjct: 930 GLWQSLSFALAGSFVMWNFAIAYMFGLWLISNGWSTPYTVFQVIEALNMASMSVMLAASY 989
Query: 1802 FPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVLDG 1981
FPEYVRARISAGIMFTMIRQ+SVIDNRGLTGDTP IKG+I+MR VYFAYPNRRRQLVLD
Sbjct: 990 FPEYVRARISAGIMFTMIRQRSVIDNRGLTGDTPPIKGDISMREVYFAYPNRRRQLVLDS 1049
Query: 1982 FNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIAL 2161
FNM+A FGQTVALVGPSGCGKSTTIQLIERYYDAL G +K+D DIR++SVKHLRDNIAL
Sbjct: 1050 FNMTAKFGQTVALVGPSGCGKSTTIQLIERYYDALSGKIKVDGCDIREISVKHLRDNIAL 1109
Query: 2162 VGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRLS 2341
VGQEPTLFNLTIRENITYGLE I+Q++VEKAATLANIHTFVMGLP+GYDTSVGASGGRLS
Sbjct: 1110 VGQEPTLFNLTIRENITYGLEKISQEEVEKAATLANIHTFVMGLPEGYDTSVGASGGRLS 1169
Query: 2342 GGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTI 2521
GGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTC+VIAHRLSTI
Sbjct: 1170 GGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCIVIAHRLSTI 1229
Query: 2522 QNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
QNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS+
Sbjct: 1230 QNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQST 1268
Score = 300 bits (767), Expect = 2e-79
Identities = 187/590 (31%), Positives = 304/590 (50%), Gaps = 14/590 (2%)
Frame = +2
Query: 905 EASLFDIFKYASPEMRNIIIS-LVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALL 1081
+ + FD+F+ + ++ ++ + + G P S+++ + L G L
Sbjct: 28 QGNFFDVFRDSDWRDYALVAGGIILSAVNGALVPFNSLIFEGIANALMEGEAQYQ-NGTL 86
Query: 1082 NSLWF-------ILLAFTGGISTLISGSLLGKAGETMSGR----LRMDVFRNIMQQDASY 1228
N WF L F G++ + T+ R +R +++++QDA +
Sbjct: 87 NMPWFSSEIKFFCLRYFYLGLALFLCSYCANACLYTLCERRLHCIRKHYLKSVLRQDAKW 146
Query: 1229 FDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXX 1408
FD +H +G LT ++++ ++ I ++ ++ G+ + GV + FY W + +
Sbjct: 147 FD--QHTIGGLTQKMSSGIEKIKDGIGDKIGVIVGGVATFISGVSLGFYMCWQLTLVMLI 204
Query: 1409 XXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAA 1588
+L + +M + A + E I+ +TV A Q + + ++
Sbjct: 205 TVPLQLGSMYLSAKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYSQQ 264
Query: 1589 SKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNM 1768
+ + + + + ++ + + A+A+ +G L + + VF V A+ +
Sbjct: 265 LEEARKMGVRKAMILAICTSFPLMLMFTCMAVAFWYGATLAAAGAVSSGAVFAVFWAVLI 324
Query: 1769 ASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFA 1945
+ + AA + AR++ +F +I + I G P I+G ++ G+ F
Sbjct: 325 GTRRIGEAAPHLGAITGARLAIHDIFKVIDHEPEIKCTSSDGKIPDKIQGKLSFDGIEFT 384
Query: 1946 YPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRD 2125
YP R +L G + N G+TVALVG SGCGKST+I L+ R+Y+ G +K+D I +
Sbjct: 385 YPTRPDLKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQGAGMIKLDGVPIHE 444
Query: 2126 LSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGY 2305
+++ LR I +V QEP +F T+ ENI G + IT D +E+A +AN H F+ L D Y
Sbjct: 445 YNIRWLRSTIGIVQQEPIIFVATVAENIRMGDDLITDDDIEEACRMANAHEFICKLSDKY 504
Query: 2306 DTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGR 2485
+T +GA +LSGGQKQRVAIARAIVR P+ILLLDEATSALDTESE++VQ ALDKA GR
Sbjct: 505 NTVIGAGAVQLSGGQKQRVAIARAIVRRPQILLLDEATSALDTESERMVQAALDKASKGR 564
Query: 2486 TCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARR-GLYYRLVEKQ 2632
T + IAHRLSTI+NA KI+V G E GTH L+++ G+Y +V Q
Sbjct: 565 TTLCIAHRLSTIKNASKILVFDQGLIAERGTHDELISKEDGIYASMVAAQ 614
>gi|39594783|emb|CAE70651.1| Hypothetical protein CBG17356
[Caenorhabditis briggsae]
Length = 1265
Score = 1365 bits (3534), Expect = 0.0
Identities = 685/879 (77%), Positives = 773/879 (87%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
++KILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAG IKLDG+PI++YNI+W
Sbjct: 388 DVKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGTIKLDGVPIEDYNIQW 447
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LRSTIGIVQQEPIIF+ATV+ENIRMGD ITD+DIE+AC+ ANAH+FI LSD Y+T+IG
Sbjct: 448 LRSTIGIVQQEPIIFLATVSENIRMGDNSITDKDIEDACRQANAHDFIGHLSDGYNTIIG 507
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQ ALDKAS+GRTTLCI
Sbjct: 508 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQAALDKASQGRTTLCI 567
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
AHRLSTIRNA+KILVFDQGLI E+GTHD+LI + +GIYASMV+AQEIERA
Sbjct: 568 AHRLSTIRNANKILVFDQGLIVEKGTHDQLI-RQNGIYASMVRAQEIERAKEDTVVEDDS 626
Query: 722 XXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXXXXGA 901
+S R TS++E +SL RDS RL QSM+S T+QVP GA
Sbjct: 627 LEEETQSISRRLSTSEDEVRKSKSLLRDSARLSQSMLSVTSQVPDWEVEIAREEMFEEGA 686
Query: 902 MEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALL 1081
MEAS+ DIF++A PE N+II+L+ TLIRG TWPAFS+VYGQLFK+ + GG+D+ A +
Sbjct: 687 MEASMMDIFRFAKPEKWNVIIALIVTLIRGITWPAFSVVYGQLFKVFAEGGEDLPTNAFV 746
Query: 1082 NSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSL 1261
+SLWFILLAFT GI+T ISGSLLGK GETMS RLR++VF+NIMQQDASYFD+ +HNVG+L
Sbjct: 747 SSLWFILLAFTSGITTFISGSLLGKTGETMSSRLRLNVFKNIMQQDASYFDEPKHNVGNL 806
Query: 1262 TSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXXX 1441
T+RLATD+ NVQAAID RLAEVL G++SLF G+ VAF++GW+MAPIG
Sbjct: 807 TARLATDSQNVQAAIDHRLAEVLNGVISLFAGIAVAFWFGWSMAPIGLLTALLLVIAQSS 866
Query: 1442 XXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVR 1621
YLK+RG +DM+SAIEASR+VTESISNWKTVQALTKQEYMY AFT ASK P +RA +
Sbjct: 867 VAQYLKYRGPKDMESAIEASRIVTESISNWKTVQALTKQEYMYGAFTTASKKPRQRAFAK 926
Query: 1622 GLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAASY 1801
GLWQSLSFALAGSF +WNFAIAYMFGLWLISNNW+TP+ VFQVIEALNMASMSVM+AASY
Sbjct: 927 GLWQSLSFALAGSFFLWNFAIAYMFGLWLISNNWTTPFAVFQVIEALNMASMSVMMAASY 986
Query: 1802 FPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVLDG 1981
FPEYVRARISAGIMFTMIRQKS IDNRGLTG+TP IKG+I+MRGVYFAYPNR+RQL+L+
Sbjct: 987 FPEYVRARISAGIMFTMIRQKSAIDNRGLTGETPLIKGDISMRGVYFAYPNRKRQLILNN 1046
Query: 1982 FNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIAL 2161
FNMSANFGQTVALVGPSGCGKSTTIQLIERYYDA+CGSV+IDD+D+RD+SVKHLRDNIAL
Sbjct: 1047 FNMSANFGQTVALVGPSGCGKSTTIQLIERYYDAVCGSVRIDDTDVRDISVKHLRDNIAL 1106
Query: 2162 VGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRLS 2341
VGQEPTLFNL+IRENITYGLEN++Q+Q+E+AA LANIH FV+ LP+GYDTSVGASGGRLS
Sbjct: 1107 VGQEPTLFNLSIRENITYGLENVSQEQIEEAAKLANIHNFVISLPEGYDTSVGASGGRLS 1166
Query: 2342 GGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTI 2521
GGQKQR+AIARAIVRDPKILLLDEATSALD+ESEKIVQEALDKARLGRTCVVIAHRLSTI
Sbjct: 1167 GGQKQRIAIARAIVRDPKILLLDEATSALDSESEKIVQEALDKARLGRTCVVIAHRLSTI 1226
Query: 2522 QNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
QNADKIIVCRNGKAIEEGTHQ+LLARRGLYYRLVEKQS+
Sbjct: 1227 QNADKIIVCRNGKAIEEGTHQSLLARRGLYYRLVEKQST 1265
Score = 306 bits (784), Expect = 2e-81
Identities = 203/590 (34%), Positives = 310/590 (52%), Gaps = 16/590 (2%)
Frame = +2
Query: 911 SLFDIFKYASP-EMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGG----------D 1057
SL ++F+++ + ++ +VF+ G P S+++ + +L G D
Sbjct: 28 SLSNLFRHSDCLDYLLLLGGIVFSSASGALLPFNSLIFEGITNVLMQGQSEWQNGTFAYD 87
Query: 1058 DVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDD 1237
S L + LL + T IS + L E +R + R++++QDA +FD+
Sbjct: 88 TFSTGIRHYCLLYFLLGVFMFLCTYISNACLYTMAERRLYCIRKHLLRSVLRQDAQWFDE 147
Query: 1238 SRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXX 1417
+ VG LT ++++ ++ I ++ + +G + GV + FY W + +
Sbjct: 148 N--TVGGLTQKMSSGIEKIKDGIGDKIGVLFSGAATFISGVLLGFYMCWQLTLVMLITVP 205
Query: 1418 XXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMY----DAFTA 1585
+L + +M + A + E I+ +TV A Q + D
Sbjct: 206 LQLGQMYMSAKHLNRATKNEMSAYSSAGGMANEVIAGIRTVIAFNAQPFEISRYADKLAE 265
Query: 1586 ASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALN 1765
A + R++IV ++ L FV+ A A+ +G L S +T T F V A+
Sbjct: 266 ARQMGIRKSIVLASCSAVPLVLM--FVL--MAGAFWYGAILTSFGIATSGTTFGVFWAVL 321
Query: 1766 MASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYF 1942
+ + + AA + + AR++ +F +I + I+ TG P I G +N + F
Sbjct: 322 LGTRRLGEAAPHMGAILGARLAINDIFKVIDNEPEINCTKETGRRPEKINGKLNFDNIEF 381
Query: 1943 AYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIR 2122
YP R +L G + N G+TVALVG SGCGKST+I L+ R+Y+ G++K+D I
Sbjct: 382 TYPTRPDVKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGTIKLDGVPIE 441
Query: 2123 DLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDG 2302
D +++ LR I +V QEP +F T+ ENI G +IT +E A AN H F+ L DG
Sbjct: 442 DYNIQWLRSTIGIVQQEPIIFLATVSENIRMGDNSITDKDIEDACRQANAHDFIGHLSDG 501
Query: 2303 YDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLG 2482
Y+T +GA +LSGGQKQRVAIARAIVR P+ILLLDEATSALDTESE++VQ ALDKA G
Sbjct: 502 YNTIIGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQAALDKASQG 561
Query: 2483 RTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
RT + IAHRLSTI+NA+KI+V G +E+GTH L+ + G+Y +V Q
Sbjct: 562 RTTLCIAHRLSTIRNANKILVFDQGLIVEKGTHDQLIRQNGIYASMVRAQ 611
>gi|17569145|ref|NP_509902.1| P-GlycoProtein related (pgp-4)
[Caenorhabditis elegans]
gi|7503247|pir||T22090 hypothetical protein F42E11.1 - Caenorhabditis
elegans
gi|3877005|emb|CAA91463.1| Hypothetical protein F42E11.1
[Caenorhabditis elegans]
Length = 1266
Score = 1365 bits (3532), Expect = 0.0
Identities = 689/880 (78%), Positives = 772/880 (87%), Gaps = 1/880 (0%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
++KILKGVSFEVNPGET+ALVGHSGCGKSTSIGLLMRFYNQCAG IKLDGIPI++YNI+W
Sbjct: 388 DVKILKGVSFEVNPGETIALVGHSGCGKSTSIGLLMRFYNQCAGSIKLDGIPIEDYNIQW 447
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LRSTIGIVQQEPIIF+ATVAEN+RMGD ITD+DIE AC+ ANAH+FI KLS+ Y+TVIG
Sbjct: 448 LRSTIGIVQQEPIIFLATVAENVRMGDDSITDKDIENACRQANAHDFIGKLSEGYNTVIG 507
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI
Sbjct: 508 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 567
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
AHRLSTIRNASKILVFDQGLI ERG HD+LI + +GIYA+MV+AQEIE+A
Sbjct: 568 AHRLSTIRNASKILVFDQGLIPERGIHDQLI-RQNGIYANMVRAQEIEKAKDDTTQDDDE 626
Query: 722 XXXXHR-SFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXXXXG 898
S R TS+EE +SL RDSTR QSM+S T+QVP G
Sbjct: 627 LVEEDNYSISRRLSTSEEELRKSKSLLRDSTRFSQSMLSVTSQVPDWEMESAREEMIEEG 686
Query: 899 AMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKAL 1078
AMEAS+ DIF++A PE NI+I+L+FTLIRG TWPAFS+VYGQLFK+ + GG+D+ + AL
Sbjct: 687 AMEASMMDIFRFAKPEKMNIVIALIFTLIRGITWPAFSVVYGQLFKVFAEGGEDLPVNAL 746
Query: 1079 LNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGS 1258
++SLWF+LLA T ++T ISGSLLGK GETMS RLRMDVF+NIMQQDA+YFDD +HNVG+
Sbjct: 747 ISSLWFVLLAVTSAVTTFISGSLLGKTGETMSSRLRMDVFKNIMQQDATYFDDPKHNVGN 806
Query: 1259 LTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXX 1438
LTSRLATD+ NVQAAID RLAEVL G+VSLF G+ VAF++GW+MAPIG
Sbjct: 807 LTSRLATDSQNVQAAIDHRLAEVLNGVVSLFTGIAVAFWFGWSMAPIGLITALLLVIAQS 866
Query: 1439 XXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIV 1618
YLK+RG +DM+SAIEASR+VTESISNWKTVQALTKQEYM+ AFTAASK+P +RA
Sbjct: 867 AVAQYLKYRGPKDMESAIEASRIVTESISNWKTVQALTKQEYMFHAFTAASKNPRKRAFT 926
Query: 1619 RGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAAS 1798
+GLWQSLSFALAGSF +WNFAIAYMFGLWLISNNW+TP+ VFQVIEALNMASMSVM+AAS
Sbjct: 927 KGLWQSLSFALAGSFFLWNFAIAYMFGLWLISNNWTTPFAVFQVIEALNMASMSVMMAAS 986
Query: 1799 YFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVLD 1978
YFPEYVRARISAGIMFTMIRQK+ IDNRGLTG+TP I+G+I+M+GVYFAYPNR RQL+L+
Sbjct: 987 YFPEYVRARISAGIMFTMIRQKAKIDNRGLTGETPDIRGDISMKGVYFAYPNRNRQLILN 1046
Query: 1979 GFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIA 2158
FNMSA FG+TVALVGPSGCGKST+IQLIERYYDA+CG+VKIDD DIRD+SVKHLR NIA
Sbjct: 1047 NFNMSAQFGETVALVGPSGCGKSTSIQLIERYYDAICGAVKIDDHDIRDISVKHLRHNIA 1106
Query: 2159 LVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRL 2338
LVGQEPTLFNLTIRENITYGLEN++Q+QVEKAATLANIH+FV LP+GYDTSVGASGGRL
Sbjct: 1107 LVGQEPTLFNLTIRENITYGLENVSQEQVEKAATLANIHSFVENLPEGYDTSVGASGGRL 1166
Query: 2339 SGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLST 2518
SGGQKQR+AIARAIVR+PKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLST
Sbjct: 1167 SGGQKQRIAIARAIVRNPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLST 1226
Query: 2519 IQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
IQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS+
Sbjct: 1227 IQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQST 1266
Score = 301 bits (771), Expect = 5e-80
Identities = 199/590 (33%), Positives = 306/590 (51%), Gaps = 16/590 (2%)
Frame = +2
Query: 911 SLFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGG----------D 1057
SL ++F+++ + ++ LV + G P S+++ + +L G D
Sbjct: 28 SLSNLFRHSGCADYLLLLGGLVLSAANGALLPFNSLIFEGITNVLMKGEAQWQNGTFDYD 87
Query: 1058 DVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDD 1237
S L + LL T S + L E +R + +++++QDA +FD+
Sbjct: 88 TFSSGIQHYCLLYFLLGVLMFTCTYFSNACLFTMAERRLYCIRKHLLQSVLRQDAKWFDE 147
Query: 1238 SRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXX 1417
+ VG LT ++++ ++ I ++ +++GI + GV + FY W + +
Sbjct: 148 N--TVGGLTQKMSSGIEKIKDGIGDKIGVLVSGIATFISGVALGFYMCWQLTLVMLVTVP 205
Query: 1418 XXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTA---- 1585
+L + +M + A + E I+ +TV A Q + + + A
Sbjct: 206 LQLGSMYLSAKHLNRATKNEMSAYSSAGGMANEVIAGIRTVIAFNAQPFEIERYGAQLAK 265
Query: 1586 ASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALN 1765
A K R+AIV L ++ L FV+ A A+ +G L S +T T F V A+
Sbjct: 266 ARKMGIRKAIVLALCSAMPLFLM--FVL--MAGAFWYGAILTSYGVATSGTTFGVFWAVI 321
Query: 1766 MASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYF 1942
+ + + AA + AR++ +F +I + I+ G P + G + + F
Sbjct: 322 LGTRRLGEAAPHMGAITGARLAVNDIFKVIDHEPEINCTKQEGRRPDKVNGKLVFDNIQF 381
Query: 1943 AYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIR 2122
YP R +L G + N G+T+ALVG SGCGKST+I L+ R+Y+ GS+K+D I
Sbjct: 382 TYPTRPDVKILKGVSFEVNPGETIALVGHSGCGKSTSIGLLMRFYNQCAGSIKLDGIPIE 441
Query: 2123 DLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDG 2302
D +++ LR I +V QEP +F T+ EN+ G ++IT +E A AN H F+ L +G
Sbjct: 442 DYNIQWLRSTIGIVQQEPIIFLATVAENVRMGDDSITDKDIENACRQANAHDFIGKLSEG 501
Query: 2303 YDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLG 2482
Y+T +GA +LSGGQKQRVAIARAIVR P+ILLLDEATSALDTESE++VQ ALDKA G
Sbjct: 502 YNTVIGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEG 561
Query: 2483 RTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
RT + IAHRLSTI+NA KI+V G E G H L+ + G+Y +V Q
Sbjct: 562 RTTLCIAHRLSTIRNASKILVFDQGLIPERGIHDQLIRQNGIYANMVRAQ 611
>gi|39595964|emb|CAE67467.1| Hypothetical protein CBG12969
[Caenorhabditis briggsae]
Length = 1231
Score = 753 bits (1943), Expect = 0.0
Identities = 395/850 (46%), Positives = 562/850 (65%), Gaps = 2/850 (0%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
++ +LKG+S NPGE +ALVGHSG GKST+ L+M FY G I +D I E N+
Sbjct: 392 KVNVLKGISLHANPGENIALVGHSGSGKSTTAALMMHFYELNGGKISIDDTNIDELNLSH 451
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR+ +GIV QEP++F TV N+R+G + D ++E CK+ANAH+FI +L + Y T IG
Sbjct: 452 LRNIVGIVSQEPLLFADTVENNMRLGAPDLDDNEMEYYCKLANAHDFIEQLPNGYKTAIG 511
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
G V+LSGGQ+QR+AIAR + RKP IL+LDEATSALD+ESE +VQ AL+ A+EGRTT+ I
Sbjct: 512 NGGVELSGGQRQRIAIARTLARKPSILILDEATSALDSESESLVQIALENAAEGRTTITI 571
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
AHRL TIRN ++I VFD G I E G+H EL+ KD G YA MV++QEIE
Sbjct: 572 AHRLGTIRNCNRIYVFDDGKIVEVGSHQELMEKD-GHYAKMVQSQEIEVGNRQESTMEEY 630
Query: 722 XXXXHRSFHRDSVTSDEERE-LQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXXXXG 898
R +S S R+ + AR + + ++S + +P
Sbjct: 631 SFESRR----ESCDSKSSRQKFSKKTARSCSLTSEKLLSDISPLPIGEE----------N 676
Query: 899 AMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV-SIKA 1075
++ +I +Y PE + IS++ +++RGF +P +SI+YG++F+ILS G D+ S +
Sbjct: 677 EQPSTFLEILRYTKPEWGLLAISILISVLRGFNYPIYSILYGRMFRILSTGTDEEKSSNS 736
Query: 1076 LLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVG 1255
+N+++ L I T+ +G L+G GE ++ RLR+ +F NI++QD YFD H G
Sbjct: 737 GMNAIYLTALGIYALIVTMAAGCLIGYVGERLTKRLRILLFTNILRQDGEYFDVPEHAPG 796
Query: 1256 SLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXX 1435
L +RL+TDAPN++AAIDQRLA+V+ G ++FCG+ +AF++ MA +G
Sbjct: 797 RLITRLSTDAPNIRAAIDQRLADVIQGFSAVFCGIAIAFWFSPTMALMGLVNVGVLISLQ 856
Query: 1436 XXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAI 1615
LK RG++D + + E SRL E++ +TVQ LT+++ F H R +
Sbjct: 857 GFITHVLKKRGEKDSERSEEPSRLAIEAVEQHRTVQYLTREQSFVKKFADGMHPIHIRNL 916
Query: 1616 VRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAA 1795
RG+ QS+S+AL+ S+ ++FAI Y FGL L+ ++ + P+TVFQVIE+LN +S S++
Sbjct: 917 QRGILQSISYALSTSYTSFSFAIGYRFGLLLVDHDLANPFTVFQVIESLNSSSPSLLALG 976
Query: 1796 SYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVL 1975
SY PE+VRA+ISAG++F M+R + ID+ TG T+ +I+++ VYF Y R+++L
Sbjct: 977 SYIPEFVRAQISAGLLFQMLRYEPKIDSN--TGKKTTLDSDISLKNVYFGYQVSGRKMIL 1034
Query: 1976 DGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNI 2155
F + G+T A+VG SGCGKSTTIQL+ER+YD + G + +++RDL++KHLR +
Sbjct: 1035 KDFTLKIESGKTTAIVGASGCGKSTTIQLLERFYDPIAGRIDFGSTNLRDLNLKHLRSQV 1094
Query: 2156 ALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGR 2335
ALV QEPTLFN +IR+NI YGLE+I + +V +AA +A+ H F+ LP+GYDT VG G +
Sbjct: 1095 ALVEQEPTLFNYSIRKNIAYGLESIKEGEVIQAAKIAHAHEFITSLPEGYDTIVGEGGSK 1154
Query: 2336 LSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLS 2515
LSGGQKQR+AIARAIVR+PKILLLDEA SALD ESE++VQEAL+KA+ GRTCVVIAHRL+
Sbjct: 1155 LSGGQKQRIAIARAIVRNPKILLLDEAMSALDVESERLVQEALEKAKEGRTCVVIAHRLT 1214
Query: 2516 TIQNADKIIV 2545
TI+ A I++
Sbjct: 1215 TIRGALLILI 1224
Score = 263 bits (673), Expect = 1e-68
Identities = 160/492 (32%), Positives = 261/492 (52%), Gaps = 7/492 (1%)
Frame = +2
Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
++R+ F +++QD +FD +++ G+ R+ V+ + +L ++ + FCG
Sbjct: 131 KIRVAYFSALLRQDWEWFD--QNDSGAAIVRMNDGLERVRDGLGDKLGVIIAYLTHFFCG 188
Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
+ +AFY M + + +++++ A+ E IS KT
Sbjct: 189 LSLAFYLSVEMTIVTLIITPAFILPIIISRKMISKVTFKELEAYESAATAAGEVISGIKT 248
Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSF------VMWNFAIAYMFG 1699
V + ++ + ++ +A+ GLW++ + G W F + +G
Sbjct: 249 VVSFNGEQKEINRYSKFLS----KAMYWGLWRASLSSFEGLLGHSSCVFQWQFHSGW-WG 303
Query: 1700 LWLISNNWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDN 1879
L+ TP T V A+N A V A + +A +F +I + ++D
Sbjct: 304 TRLVLKGSITPGTTLAVFWAVNGAIYFVGQAIPHLTSVSSCYSAAVPVFQIIDRTVILDG 363
Query: 1880 RGLTG-DTPTIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTI 2056
G +KG + V+F YP R++ VL G ++ AN G+ +ALVG SG GKSTT
Sbjct: 364 TSDKGLKLSKVKGKVKFENVWFKYPARQKVNVLKGISLHANPGENIALVGHSGSGKSTTA 423
Query: 2057 QLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQ 2236
L+ +Y+ G + IDD++I +L++ HLR+ + +V QEP LF T+ N+ G ++
Sbjct: 424 ALMMHFYELNGGKISIDDTNIDELNLSHLRNIVGIVSQEPLLFADTVENNMRLGAPDLDD 483
Query: 2237 DQVEKAATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEA 2416
+++E LAN H F+ LP+GY T++G G LSGGQ+QR+AIAR + R P IL+LDEA
Sbjct: 484 NEMEYYCKLANAHDFIEQLPNGYKTAIGNGGVELSGGQRQRIAIARTLARKPSILILDEA 543
Query: 2417 TSALDTESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLA 2596
TSALD+ESE +VQ AL+ A GRT + IAHRL TI+N ++I V +GK +E G+HQ L+
Sbjct: 544 TSALDSESESLVQIALENAAEGRTTITIAHRLGTIRNCNRIYVFDDGKIVEVGSHQELME 603
Query: 2597 RRGLYYRLVEKQ 2632
+ G Y ++V+ Q
Sbjct: 604 KDGHYAKMVQSQ 615
>gi|17558664|ref|NP_507487.1| P-GlycoProtein related (pgp-9)
[Caenorhabditis elegans]
gi|7497530|pir||T19982 hypothetical protein C47A10.1 - Caenorhabditis
elegans
gi|3875004|emb|CAB03973.1| Hypothetical protein C47A10.1
[Caenorhabditis elegans]
gi|3879215|emb|CAB07855.1| Hypothetical protein C47A10.1
[Caenorhabditis elegans]
Length = 1294
Score = 732 bits (1890), Expect = 0.0
Identities = 401/895 (44%), Positives = 560/895 (61%), Gaps = 16/895 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
++KILKGVS + PG+TVALVG SGCGKST I LL RFYN AG I +D IPI+++NI++
Sbjct: 397 DVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKY 456
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR +G+V QEP +F ++ +NIR G ++D+DI A K ANA +FI + +T++G
Sbjct: 457 LRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLVG 516
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
VQ+SGGQKQR+AIARA+VR P+ILLLDEATSALD ESE +VQ+AL+ AS GRTT+ I
Sbjct: 517 DRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVI 576
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
AHRLST+RNA KI+V G + E GTH+ LI + G+Y +V AQ
Sbjct: 577 AHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQK-GLYHELVHAQVFADVDDKPKKKEAE 635
Query: 722 XXXXHRSFHRDSVTSDEERELQ-----------QSLARDSTRLRQSMISTTTQVPXXXXX 868
++ R + + +E Q ++ ++ RL++ +
Sbjct: 636 RRMSRQTSQRKGSVNFKTQESQVDEKPGAPPAPEAAEKEIKRLKKEL------------- 682
Query: 869 XXXXXXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILS- 1045
GA++A+LF I +YA PE I +++ LI+G PAFS+ + Q+ + S
Sbjct: 683 ------EEEGAVKANLFKILRYARPEWIYIFFAIIAALIQGAVMPAFSLFFSQIINVFSN 736
Query: 1046 AGGDDVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDAS 1225
D + +L F++LA G S L SL G A E ++ R+R V+RN+++QDA+
Sbjct: 737 PDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDAT 796
Query: 1226 YFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGX 1405
YFD +H+ G +T+RLATDAPN+++AID RL + I S+ G+G+AFYYGW MA +
Sbjct: 797 YFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVM 856
Query: 1406 XXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTA 1585
Y D A + E+I N +TVQALT Q +Y+ F +
Sbjct: 857 AIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCS 916
Query: 1586 ASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLI--SNNWSTPYTVFQVIEA 1759
+PH I + + + L++ A S + +A A+ FGL+LI N P V +V+ A
Sbjct: 917 HLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFA 976
Query: 1760 LNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVY 1939
++ + ++ AASYFPEY++A +AG++F M+ ++ ID +G P + G + + V+
Sbjct: 977 ISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVF 1036
Query: 1940 FAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDI 2119
F YP R +L G N+ GQT+ALVGPSGCGKST I L+ER YD L G+V +D++D+
Sbjct: 1037 FRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDL 1096
Query: 2120 RDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLE--NITQDQVEKAATLANIHTFVMGL 2293
R ++ KHLR +IALV QEP LF+ +IRENI YGL+ T +Q+E A + ANIH F+ L
Sbjct: 1097 RQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDEL 1156
Query: 2294 PDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKA 2473
PDGY+T VG G +LSGGQKQR+AIARA++R+PKILLLDEATSALDTESEK VQ ALD A
Sbjct: 1157 PDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAA 1216
Query: 2474 RLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
RTC+V+AHRLSTI NA I+V +NG+ +E+GTH L+A+RG Y+ L +KQSS
Sbjct: 1217 AKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSS 1271
Score = 313 bits (801), Expect = 2e-83
Identities = 198/593 (33%), Positives = 308/593 (51%), Gaps = 19/593 (3%)
Frame = +2
Query: 911 SLFDIFKYASPEMRNII-ISLVFTLIRGFTWPAFSIVYG---QLFKIL------------ 1042
S+F +++Y S R ++ + ++ + G P SI+ G Q F L
Sbjct: 30 SIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTAS 89
Query: 1043 --SAGGDDVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQ 1216
+A + S + + N L ++ L + + S E +S R R F ++M+Q
Sbjct: 90 EKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQ 149
Query: 1217 DASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAP 1396
+ +++D ++ G+L+++L + V+ ++ + G VAF Y W +
Sbjct: 150 EIAWYD--KNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 207
Query: 1397 IGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDA 1576
I L ++ A + E +++ +TV A QEY
Sbjct: 208 IMMSLSPFMMICGLFLAKLLATAATKEAKQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 267
Query: 1577 FTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIE 1756
+ A + + I + A + ++ +A+ G + + TV V
Sbjct: 268 YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 327
Query: 1757 ALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRG 1933
++ M SM++ A F A +A ++ +I + ID G TP+ I G I++
Sbjct: 328 SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 387
Query: 1934 VYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDS 2113
V F YP R +L G ++ A GQTVALVG SGCGKST IQL++R+Y+ G + IDD
Sbjct: 388 VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 447
Query: 2114 DIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGL 2293
I D ++K+LR + +V QEP LFN +I +NI YG +++ + + +A AN F+
Sbjct: 448 PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 507
Query: 2294 PDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKA 2473
P+G +T VG G ++SGGQKQR+AIARA+VR+PKILLLDEATSALD ESE IVQ AL+ A
Sbjct: 508 PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 567
Query: 2474 RLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
GRT +VIAHRLST++NADKIIV + G+ +E GTH+TL+ ++GLY+ LV Q
Sbjct: 568 SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQ 620
>gi|39587899|emb|CAE67917.1| Hypothetical protein CBG13514
[Caenorhabditis briggsae]
Length = 1319
Score = 712 bits (1837), Expect = 0.0
Identities = 390/893 (43%), Positives = 552/893 (61%), Gaps = 14/893 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
++ IL+G++ VN G+TVALVG SGCGKST I LL+R+Y+ G I +DG+ +++ N+ +
Sbjct: 430 DVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYYDVLKGNITIDGVDVRDINLEF 489
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR+ + +V QEP +F T+ ENIR+G IT +++ ACKMANA +FI L Y+T++G
Sbjct: 490 LRTNVAVVSQEPALFNCTIEENIRLGREDITREEMIAACKMANAEKFIKTLPAGYNTLVG 549
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
QLSGGQKQR+AIARA+VR P+ILLLDEATSALD ESE +VQ ALDKA++GRTT+ I
Sbjct: 550 DRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESEGIVQQALDKAAKGRTTIII 609
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
AHRLSTIRNA I+ G + E G H L+++ +G+Y +V AQ A
Sbjct: 610 AHRLSTIRNADLIISCKNGQVVEVGDHRTLMAQ-EGLYYDLVTAQTFTDA---VDASAGG 665
Query: 722 XXXXHRSFHRDSVTSDEERELQQSLARDS--TRLRQSMISTTTQVP----------XXXX 865
S R TS+ E +Q+ D R+R S + + T P
Sbjct: 666 KFSRENSIARQ--TSEHEGIFRQASELDDVLNRVRSSTMGSITNGPVIEEKEQRIGKDAL 723
Query: 866 XXXXXXXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILS 1045
A +LF+I +A P ++ I + ++ GF +P +S+ + + S
Sbjct: 724 TRLKEELEENNAQRTNLFEILYHAKPHALSVAIGITAAIVGGFIYPTYSVFFTSFINVFS 783
Query: 1046 AGGDDVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDAS 1225
DD+ + +L F++LA GI + + +G A E+++ LR +FRN++ Q
Sbjct: 784 GNPDDILSQGHFWALMFLVLAAAQGICSFLMTFFMGIASESLTMDLRNKLFRNVLSQHIG 843
Query: 1226 YFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGX 1405
+FD ++ G + +RLATD PN++ AID R + V+T +VS+ G+G+AFYYGW MA +
Sbjct: 844 FFDSPQNASGKICTRLATDVPNLRTAIDFRFSTVITTLVSMIAGIGLAFYYGWQMALLIV 903
Query: 1406 XXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTA 1585
+ ++ ++ E+I N +TVQAL +++ Y F +
Sbjct: 904 AILPIVGFGQYLRGRRFTGNNVKSASEFADSGKIAIEAIENVRTVQALAREDTFYYKFCS 963
Query: 1586 ASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALN 1765
PH+ AI Q LS+ A S + AY GL LI + TP V +V+ A+
Sbjct: 964 KLDVPHKEAIKEAFIQGLSYGCACSVLYLLNTCAYRMGLALILHRTMTPMRVLRVMYAIT 1023
Query: 1766 MASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFA 1945
+++ ++ A SYFPEY +A + GI+F M++QKS ID+ L+G+ + G + + V FA
Sbjct: 1024 ISTSTLGFATSYFPEYAKATFAGGIIFGMLKQKSEIDSLTLSGEKKKLSGKVIFKNVRFA 1083
Query: 1946 YPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRD 2125
YP R + +L G + S + GQT+ALVGPSGCGKST + L+ER+YD L G V ID S+I+
Sbjct: 1084 YPERPQIEILKGLSFSVDPGQTLALVGPSGCGKSTVVALLERFYDTLAGEVFIDGSEIKT 1143
Query: 2126 LSVKHLRDNIALVGQEPTLFNLTIRENITYGLE--NITQDQVEKAATLANIHTFVMGLPD 2299
L+ ++ R IA+V QEPTLF+ +I ENI YGL+ +T +VE+AA LANIH F+ LP+
Sbjct: 1144 LNPENTRSQIAIVSQEPTLFDCSIAENIVYGLDPTTVTMSRVEEAAKLANIHNFISELPE 1203
Query: 2300 GYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARL 2479
GY+T VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESEKIVQEALD+AR
Sbjct: 1204 GYETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEKIVQEALDRARE 1263
Query: 2480 GRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
GRTC+VIAHRL+TI NAD I V NG IE+GTH L++++G YY+L +KQ S
Sbjct: 1264 GRTCIVIAHRLNTIMNADCIAVVNNGTIIEQGTHSVLMSQQGAYYKLTQKQMS 1316
Score = 352 bits (903), Expect = 3e-95
Identities = 196/492 (39%), Positives = 295/492 (59%), Gaps = 1/492 (0%)
Frame = +2
Query: 1163 ETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIV 1342
E M+ RLR + + I++QD S+FD + G+L ++L + V+ ++ +
Sbjct: 165 EQMNNRLRREFVKAILRQDISWFDTNHS--GTLATKLFDNLERVKEGTGDKIGMAFQYMS 222
Query: 1343 SLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESI 1522
G VAF + W + + + R+ +A ++V E+I
Sbjct: 223 QFITGFIVAFTHSWKLTLVMLAVTPIQALCGFLIAKSMSTFAIRETVRYAKAGKVVEETI 282
Query: 1523 SNWKTVQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGL 1702
S+ +TV +L + + ++ A + + +++GL+ +SF + ++FA+A+ G+
Sbjct: 283 SSIRTVVSLNGLRHELERYSTAVEEAKKSGVLKGLFLGISFGAMQATNFFSFALAFYIGV 342
Query: 1703 WLISNNWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNR 1882
+ + P + ++ M SM++ LA A+ +A ++ ++ +K VID+
Sbjct: 343 GWVHDGSLAPGDMLTTFSSVMMGSMALGLAGPQLAVLGTAQGAASSIYEVLDRKPVIDSS 402
Query: 1883 GLTGDTPT-IKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQ 2059
G IKG+I + V+F YP+R+ +L G N+ N GQTVALVG SGCGKST I
Sbjct: 403 SSAGRKDMKIKGDITVENVHFTYPSRQDVPILRGMNLRVNAGQTVALVGSSGCGKSTIIS 462
Query: 2060 LIERYYDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQD 2239
L+ RYYD L G++ ID D+RD++++ LR N+A+V QEP LFN TI ENI G E+IT++
Sbjct: 463 LLLRYYDVLKGNITIDGVDVRDINLEFLRTNVAVVSQEPALFNCTIEENIRLGREDITRE 522
Query: 2240 QVEKAATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEAT 2419
++ A +AN F+ LP GY+T VG G +LSGGQKQR+AIARA+VR+PKILLLDEAT
Sbjct: 523 EMIAACKMANAEKFIKTLPAGYNTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEAT 582
Query: 2420 SALDTESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLAR 2599
SALD ESE IVQ+ALDKA GRT ++IAHRLSTI+NAD II C+NG+ +E G H+TL+A+
Sbjct: 583 SALDAESEGIVQQALDKAAKGRTTIIIAHRLSTIRNADLIISCKNGQVVEVGDHRTLMAQ 642
Query: 2600 RGLYYRLVEKQS 2635
GLYY LV Q+
Sbjct: 643 EGLYYDLVTAQT 654
>gi|39585393|emb|CAE61715.1| Hypothetical protein CBG05664
[Caenorhabditis briggsae]
Length = 1294
Score = 710 bits (1832), Expect = 0.0
Identities = 395/894 (44%), Positives = 548/894 (61%), Gaps = 16/894 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
+++ILK VS E PG+T+ALVG SGCGKST I LL RFYN AG I +D I I+++NI++
Sbjct: 397 DVQILKDVSLEAQPGQTIALVGSSGCGKSTIIQLLQRFYNPDAGKIYIDDIAIEDFNIKY 456
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR +G+V QEP +F ++ +NIR G + I A K ANA +FI + +T++G
Sbjct: 457 LRQLVGVVSQEPNLFNTSIEQNIRYGRADVDSDAINRALKEANALDFIKTFPEGLNTLVG 516
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
VQ+SGGQKQR+AIARA+VR P+ILLLDEATSALD ESE +VQ ALD AS GRTT+ I
Sbjct: 517 DRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESVVQAALDNASRGRTTIVI 576
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
AHRLST+RNA KI+V G + E GTHD LI + G+Y +V AQ
Sbjct: 577 AHRLSTVRNADKIIVMKAGKVMEIGTHDTLIEQK-GLYHELVHAQVFADVDEKPRAKKEA 635
Query: 722 XXXXHR--SFHRDSVTSDEERELQQSLA---------RDSTRLRQSMISTTTQVPXXXXX 868
R S + S+ +E + ++ ++ RLR+ +
Sbjct: 636 ERRLSRQTSARKGSLIKTQESQAEEKSGPPPAPEPAEKEIKRLRKEL------------- 682
Query: 869 XXXXXXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILS- 1045
GA++A+LF I KYA PE I +++ LI+G PAFS+ + Q+ + S
Sbjct: 683 ------EEEGAVKANLFKILKYARPEWMYIFFAIIAALIQGAVMPAFSLFFSQIINVFSN 736
Query: 1046 AGGDDVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDAS 1225
+ + +L F++LA G S L + G A E ++ R+R V+RN+++QDA+
Sbjct: 737 PDREQMKKDGHFWALMFLVLAAIQGTSMLFQCAFFGVAAEGLTMRVRSKVYRNVLRQDAT 796
Query: 1226 YFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGX 1405
YFD +H+ G +T+RLATDAPN+++AID RL V I S+ G+G+AFYYGW MA +
Sbjct: 797 YFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSVFNAIASVGGGLGIAFYYGWQMALLVM 856
Query: 1406 XXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTA 1585
Y D + + E+I N +TVQALT Q +Y+ F +
Sbjct: 857 AIFPFMAVGQALVIKYHGGSATADAKEMENSGKTAMEAIENIRTVQALTLQTKLYNIFCS 916
Query: 1586 ASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNN--WSTPYTVFQVIEA 1759
SPH + + + + L++ A S + +A A+ FGL+LI N +P V +V+ A
Sbjct: 917 HLDSPHSGNVSKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFNQNVLMSPEHVLKVLFA 976
Query: 1760 LNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVY 1939
++ + ++ AASYFPEY++A +AG++F M+ ++ ID G P + G + + V+
Sbjct: 977 ISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTNAGTLPALSGEVKLNKVF 1036
Query: 1940 FAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDI 2119
F YP R +L G ++ GQT+ALVGPSGCGKST I L+ER YD L G+V ID++++
Sbjct: 1037 FRYPERPAVPILQGLDVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTIDNNNL 1096
Query: 2120 RDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLE--NITQDQVEKAATLANIHTFVMGL 2293
R ++ KHLR +IALV QEP LF+ +IRENI YGL+ T++ + A ANIH F+ L
Sbjct: 1097 RQMNPKHLRKHIALVSQEPILFDTSIRENIIYGLQPGEYTEEAIAVACEKANIHKFISEL 1156
Query: 2294 PDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKA 2473
PDGY T VG G +LSGGQKQR+AIARA++R+PKILLLDEATSALDTESEK VQ ALD A
Sbjct: 1157 PDGYQTRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQIALDAA 1216
Query: 2474 RLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
RTC+V+AHRLSTI NA I+V +NGK +E+GTH L+A+RG Y+ L +KQS
Sbjct: 1217 AKDRTCIVVAHRLSTIVNAGCIMVVKNGKVVEQGTHLELMAKRGAYFALTQKQS 1270
Score = 318 bits (815), Expect = 4e-85
Identities = 198/592 (33%), Positives = 303/592 (50%), Gaps = 18/592 (3%)
Frame = +2
Query: 911 SLFDIFKYASPEMR-NIIISLVFTLIRGFTWPAFSIVYGQLFK----------------I 1039
S+F +F+Y S R +I+ ++ + G P SI+ G + + +
Sbjct: 31 SIFQLFRYTSTMDRIMLIVGILVSCATGLGLPLMSIIMGNVSQNFVEIGTILMNSTDPAV 90
Query: 1040 LSAGGDDVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQD 1219
+ DD S + N L ++ L + +I S E +S R R + F ++M+ +
Sbjct: 91 IKKAKDDFSHDVIQNCLQYVYLGAGIFAAGMIQASCFLIICENLSNRFRREFFYSVMRHE 150
Query: 1220 ASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPI 1399
+++D ++ G+L+++L + V+ ++ + G VAF Y W + I
Sbjct: 151 IAWYD--KNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFLGGFAVAFSYDWLLTLI 208
Query: 1400 GXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAF 1579
L ++ A + E +++ +TV A QEY +
Sbjct: 209 MMSLSPFMMICGLFLAKLLATAATKEAKQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRY 268
Query: 1580 TAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEA 1759
A + I + A + ++ +A+ G + N TV V +
Sbjct: 269 EEALSHGRKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYNGRLDSGTVLTVFFS 328
Query: 1760 LNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGV 1936
+ M SM++ A F A +A ++ +I + ID G TP I G I ++ +
Sbjct: 329 VMMGSMALGQAGQQFATIGTALGAAASLYEVIDRTPEIDAYSTKGVTPEKISGRIKIQNI 388
Query: 1937 YFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSD 2116
F YP R +L ++ A GQT+ALVG SGCGKST IQL++R+Y+ G + IDD
Sbjct: 389 EFTYPTRPDVQILKDVSLEAQPGQTIALVGSSGCGKSTIIQLLQRFYNPDAGKIYIDDIA 448
Query: 2117 IRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLP 2296
I D ++K+LR + +V QEP LFN +I +NI YG ++ D + +A AN F+ P
Sbjct: 449 IEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRADVDSDAINRALKEANALDFIKTFP 508
Query: 2297 DGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKAR 2476
+G +T VG G ++SGGQKQR+AIARA+VR+PKILLLDEATSALD ESE +VQ ALD A
Sbjct: 509 EGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESVVQAALDNAS 568
Query: 2477 LGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
GRT +VIAHRLST++NADKIIV + GK +E GTH TL+ ++GLY+ LV Q
Sbjct: 569 RGRTTIVIAHRLSTVRNADKIIVMKAGKVMEIGTHDTLIEQKGLYHELVHAQ 620
Score = 215 bits (547), Expect = 5e-54
Identities = 117/229 (51%), Positives = 156/229 (68%), Gaps = 2/229 (0%)
Frame = +2
Query: 11 ILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWLRS 190
IL+G+ V PG+T+ALVG SGCGKST I LL R Y+ G + +D +++ N + LR
Sbjct: 1047 ILQGLDVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTIDNNNLRQMNPKHLRK 1106
Query: 191 TIGIVQQEPIIFVATVAENIRMG--DVLITDQDIEEACKMANAHEFICKLSDRYDTVIGA 364
I +V QEPI+F ++ ENI G T++ I AC+ AN H+FI +L D Y T +G
Sbjct: 1107 HIALVSQEPILFDTSIRENIIYGLQPGEYTEEAIAVACEKANIHKFISELPDGYQTRVGE 1166
Query: 365 GAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIA 544
QLSGGQKQR+AIARA++R P+ILLLDEATSALDTESE+ VQ ALD A++ RT + +A
Sbjct: 1167 KGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQIALDAAAKDRTCIVVA 1226
Query: 545 HRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERA 691
HRLSTI NA I+V G + E+GTH EL++K G Y ++ + Q I +A
Sbjct: 1227 HRLSTIVNAGCIMVVKNGKVVEQGTHLELMAK-RGAYFALTQKQSINQA 1274
>gi|283551|pir||S27337 multidrug resistance protein A - Caenorhabditis
elegans
gi|6809|emb|CAA46190.1| P-glycoprotein A [Caenorhabditis elegans]
Length = 1321
Score = 692 bits (1787), Expect = 0.0
Identities = 384/897 (42%), Positives = 547/897 (60%), Gaps = 20/897 (2%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
++ IL+G++ VN G+TVALVG SGCGKST I LL+R+Y+ G I +DG+ +++ N+ +
Sbjct: 430 DVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYYDVLKGKITIDGVDVRDINLEF 489
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR + +V QEP +F T+ ENI +G IT +++ ACKMANA +FI L + Y+T++G
Sbjct: 490 LRKNVAVVSQEPALFNCTIEENISLGKEGITREEMVAACKMANAEKFIKTLPNGYNTLVG 549
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
QLSGGQKQR+AIARA+VR P+ILLLDEATSALD ESE +VQ ALDKA++GRTT+ I
Sbjct: 550 DRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESEGIVQQALDKAAKGRTTIII 609
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
AHRLSTIRNA I+ G + E G H L+++ G+Y +V AQ A
Sbjct: 610 AHRLSTIRNADLIISCKNGQVVEVGDHRALMAQ-QGLYYDLVTAQTFTDA---------V 659
Query: 722 XXXXHRSFHRDS----VTSDEERELQQSLARDS--TRLRQSMISTTTQVP---------- 853
F R++ TS+ E +Q+ D R+R S I + T P
Sbjct: 660 DSAAEGKFSRENSVARQTSEHEGLSRQASEMDDIMNRVRSSTIGSITNGPVIDEKEERIG 719
Query: 854 XXXXXXXXXXXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLF 1033
A + +LF+I +A P ++ I + I GF +P +S+ +
Sbjct: 720 KDALSRLKQELEENNAQKTNLFEILYHARPHALSLFIGMSTATIGGFIYPTYSVFFTSFM 779
Query: 1034 KILSAGGDDVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQ 1213
+ + D + +L F++LA GI + + +G A E+++ LR +FRN++
Sbjct: 780 NVFAGNPADFLSQGHFWALMFLVLAAAQGICSFLMTFFMGIASESLTRDLRNKLFRNVLS 839
Query: 1214 QDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMA 1393
Q +FD ++ G +++RLATD PN++ AID R + V+T +VS+ G+G+AF+YGW MA
Sbjct: 840 QHIGFFDSPQNASGKISTRLATDVPNLRTAIDFRFSTVITTLVSMVAGIGLAFFYGWQMA 899
Query: 1394 PIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYD 1573
+ + + ++ ++ E+I N +TVQAL +++ Y+
Sbjct: 900 LLIIAILPIVAFGQYLRGRRFTGKNVKSASEFADSGKIAIEAIENVRTVQALAREDTFYE 959
Query: 1574 AFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWST--PYTVFQ 1747
F PH+ AI Q LS+ A S + AY GL LI + T P V +
Sbjct: 960 NFCEKLDIPHKEAIKEAFIQGLSYGCASSVLYLLNTCAYRMGLALIITDPPTMQPMRVLR 1019
Query: 1748 VIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINM 1927
V+ A+ +++ ++ A SYFPEY +A + GI+F M+R+ S ID+ L G+ + G +
Sbjct: 1020 VMYAITISTSTLGFATSYFPEYAKATFAGGIIFGMLRKISKIDSLSLAGEKKKLYGKVIF 1079
Query: 1928 RGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKID 2107
+ V FAYP R +L G + S GQT+ALVGPSGCGKST + L+ER+YD L G + ID
Sbjct: 1080 KNVRFAYPERPEIEILKGLSFSVEPGQTLALVGPSGCGKSTVVALLERFYDTLGGEIFID 1139
Query: 2108 DSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLE--NITQDQVEKAATLANIHTF 2281
S+I+ L+ +H R IA+V QEPTLF+ +I ENI YGL+ ++T QVE+AA LANIH F
Sbjct: 1140 GSEIKTLNPEHTRSQIAIVSQEPTLFDCSIAENIIYGLDPSSVTMAQVEEAARLANIHNF 1199
Query: 2282 VMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEA 2461
+ LP+G++T VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESEK+VQEA
Sbjct: 1200 IAELPEGFETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEKVVQEA 1259
Query: 2462 LDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
LD+AR GRTC+VIAHRL+T+ NAD I V NG IE+GTH L++ +G YY+L +KQ
Sbjct: 1260 LDRAREGRTCIVIAHRLNTVMNADCIAVVSNGTIIEKGTHTQLMSEKGAYYKLTQKQ 1316
Score = 346 bits (888), Expect = 1e-93
Identities = 194/492 (39%), Positives = 293/492 (59%), Gaps = 1/492 (0%)
Frame = +2
Query: 1163 ETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIV 1342
E M+ RLR + ++I++Q+ S+FD + G+L ++L + V+ ++ +
Sbjct: 165 EQMNNRLRREFVKSILRQEISWFDTNHS--GTLATKLFDNLERVKEGTGDKIGMAFQYLS 222
Query: 1343 SLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESI 1522
G VAF + W + + + R+ +A ++V E+I
Sbjct: 223 QFITGFIVAFTHSWQLTLVMLAVTPIQALCGFAIAKSMSTFAIRETLRYAKAGKVVEETI 282
Query: 1523 SNWKTVQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGL 1702
S+ +TV +L Y + ++ A + + +++GL+ +SF + +FA+A+ G+
Sbjct: 283 SSIRTVVSLNGLRYELERYSTAVEEAKKAGVLKGLFLGISFGAMQASNFISFALAFYIGV 342
Query: 1703 WLISNNWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNR 1882
+ + + ++ M SM++ LA A+ +A ++ ++ +K VID+
Sbjct: 343 GWVHDGSLNFGDMLTTFSSVMMGSMALGLAGPQLAVLGTAQGAASGIYEVLDRKPVIDSS 402
Query: 1883 GLTGDTPT-IKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQ 2059
G IKG+I + V+F YP+R +L G N+ N GQTVALVG SGCGKST I
Sbjct: 403 SKAGRKDMKIKGDITVENVHFTYPSRPDVPILRGMNLRVNAGQTVALVGSSGCGKSTIIS 462
Query: 2060 LIERYYDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQD 2239
L+ RYYD L G + ID D+RD++++ LR N+A+V QEP LFN TI ENI+ G E IT++
Sbjct: 463 LLLRYYDVLKGKITIDGVDVRDINLEFLRKNVAVVSQEPALFNCTIEENISLGKEGITRE 522
Query: 2240 QVEKAATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEAT 2419
++ A +AN F+ LP+GY+T VG G +LSGGQKQR+AIARA+VR+PKILLLDEAT
Sbjct: 523 EMVAACKMANAEKFIKTLPNGYNTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEAT 582
Query: 2420 SALDTESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLAR 2599
SALD ESE IVQ+ALDKA GRT ++IAHRLSTI+NAD II C+NG+ +E G H+ L+A+
Sbjct: 583 SALDAESEGIVQQALDKAAKGRTTIIIAHRLSTIRNADLIISCKNGQVVEVGDHRALMAQ 642
Query: 2600 RGLYYRLVEKQS 2635
+GLYY LV Q+
Sbjct: 643 QGLYYDLVTAQT 654
>gi|17541710|ref|NP_502413.1| P-GlycoProtein related (pgp-1)
[Caenorhabditis elegans]
gi|29429182|sp|P34712|MDR1_CAEEL Multidrug resistance protein 1
(P-glycoprotein A)
gi|7505559|pir||T23476 hypothetical protein K08E7.9 - Caenorhabditis
elegans
gi|3878418|emb|CAB01232.1| Hypothetical protein K08E7.9
[Caenorhabditis elegans]
Length = 1321
Score = 692 bits (1787), Expect = 0.0
Identities = 384/897 (42%), Positives = 547/897 (60%), Gaps = 20/897 (2%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
++ IL+G++ VN G+TVALVG SGCGKST I LL+R+Y+ G I +DG+ +++ N+ +
Sbjct: 430 DVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYYDVLKGKITIDGVDVRDINLEF 489
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR + +V QEP +F T+ ENI +G IT +++ ACKMANA +FI L + Y+T++G
Sbjct: 490 LRKNVAVVSQEPALFNCTIEENISLGKEGITREEMVAACKMANAEKFIKTLPNGYNTLVG 549
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
QLSGGQKQR+AIARA+VR P+ILLLDEATSALD ESE +VQ ALDKA++GRTT+ I
Sbjct: 550 DRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESEGIVQQALDKAAKGRTTIII 609
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
AHRLSTIRNA I+ G + E G H L+++ G+Y +V AQ A
Sbjct: 610 AHRLSTIRNADLIISCKNGQVVEVGDHRALMAQ-QGLYYDLVTAQTFTDA---------V 659
Query: 722 XXXXHRSFHRDS----VTSDEERELQQSLARDS--TRLRQSMISTTTQVP---------- 853
F R++ TS+ E +Q+ D R+R S I + T P
Sbjct: 660 DSAAEGKFSRENSVARQTSEHEGLSRQASEMDDIMNRVRSSTIGSITNGPVIDEKEERIG 719
Query: 854 XXXXXXXXXXXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLF 1033
A + +LF+I +A P ++ I + I GF +P +S+ +
Sbjct: 720 KDALSRLKQELEENNAQKTNLFEILYHARPHALSLFIGMSTATIGGFIYPTYSVFFTSFM 779
Query: 1034 KILSAGGDDVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQ 1213
+ + D + +L F++LA GI + + +G A E+++ LR +FRN++
Sbjct: 780 NVFAGNPADFLSQGHFWALMFLVLAAAQGICSFLMTFFMGIASESLTRDLRNKLFRNVLS 839
Query: 1214 QDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMA 1393
Q +FD ++ G +++RLATD PN++ AID R + V+T +VS+ G+G+AF+YGW MA
Sbjct: 840 QHIGFFDSPQNASGKISTRLATDVPNLRTAIDFRFSTVITTLVSMVAGIGLAFFYGWQMA 899
Query: 1394 PIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYD 1573
+ + + ++ ++ E+I N +TVQAL +++ Y+
Sbjct: 900 LLIIAILPIVAFGQYLRGRRFTGKNVKSASEFADSGKIAIEAIENVRTVQALAREDTFYE 959
Query: 1574 AFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWST--PYTVFQ 1747
F PH+ AI Q LS+ A S + AY GL LI + T P V +
Sbjct: 960 NFCEKLDIPHKEAIKEAFIQGLSYGCASSVLYLLNTCAYRMGLALIITDPPTMQPMRVLR 1019
Query: 1748 VIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINM 1927
V+ A+ +++ ++ A SYFPEY +A + GI+F M+R+ S ID+ L G+ + G +
Sbjct: 1020 VMYAITISTSTLGFATSYFPEYAKATFAGGIIFGMLRKISKIDSLSLAGEKKKLYGKVIF 1079
Query: 1928 RGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKID 2107
+ V FAYP R +L G + S GQT+ALVGPSGCGKST + L+ER+YD L G + ID
Sbjct: 1080 KNVRFAYPERPEIEILKGLSFSVEPGQTLALVGPSGCGKSTVVALLERFYDTLGGEIFID 1139
Query: 2108 DSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLE--NITQDQVEKAATLANIHTF 2281
S+I+ L+ +H R IA+V QEPTLF+ +I ENI YGL+ ++T QVE+AA LANIH F
Sbjct: 1140 GSEIKTLNPEHTRSQIAIVSQEPTLFDCSIAENIIYGLDPSSVTMAQVEEAARLANIHNF 1199
Query: 2282 VMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEA 2461
+ LP+G++T VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESEK+VQEA
Sbjct: 1200 IAELPEGFETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEKVVQEA 1259
Query: 2462 LDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
LD+AR GRTC+VIAHRL+T+ NAD I V NG IE+GTH L++ +G YY+L +KQ
Sbjct: 1260 LDRAREGRTCIVIAHRLNTVMNADCIAVVSNGTIIEKGTHTQLMSEKGAYYKLTQKQ 1316
Score = 346 bits (888), Expect = 1e-93
Identities = 194/492 (39%), Positives = 293/492 (59%), Gaps = 1/492 (0%)
Frame = +2
Query: 1163 ETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIV 1342
E M+ RLR + ++I++Q+ S+FD + G+L ++L + V+ ++ +
Sbjct: 165 EQMNNRLRREFVKSILRQEISWFDTNHS--GTLATKLFDNLERVKEGTGDKIGMAFQYLS 222
Query: 1343 SLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESI 1522
G VAF + W + + + R+ +A ++V E+I
Sbjct: 223 QFITGFIVAFTHSWQLTLVMLAVTPIQALCGFAIAKSMSTFAIRETLRYAKAGKVVEETI 282
Query: 1523 SNWKTVQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGL 1702
S+ +TV +L Y + ++ A + + +++GL+ +SF + +FA+A+ G+
Sbjct: 283 SSIRTVVSLNGLRYELERYSTAVEEAKKAGVLKGLFLGISFGAMQASNFISFALAFYIGV 342
Query: 1703 WLISNNWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNR 1882
+ + + ++ M SM++ LA A+ +A ++ ++ +K VID+
Sbjct: 343 GWVHDGSLNFGDMLTTFSSVMMGSMALGLAGPQLAVLGTAQGAASGIYEVLDRKPVIDSS 402
Query: 1883 GLTGDTPT-IKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQ 2059
G IKG+I + V+F YP+R +L G N+ N GQTVALVG SGCGKST I
Sbjct: 403 SKAGRKDMKIKGDITVENVHFTYPSRPDVPILRGMNLRVNAGQTVALVGSSGCGKSTIIS 462
Query: 2060 LIERYYDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQD 2239
L+ RYYD L G + ID D+RD++++ LR N+A+V QEP LFN TI ENI+ G E IT++
Sbjct: 463 LLLRYYDVLKGKITIDGVDVRDINLEFLRKNVAVVSQEPALFNCTIEENISLGKEGITRE 522
Query: 2240 QVEKAATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEAT 2419
++ A +AN F+ LP+GY+T VG G +LSGGQKQR+AIARA+VR+PKILLLDEAT
Sbjct: 523 EMVAACKMANAEKFIKTLPNGYNTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEAT 582
Query: 2420 SALDTESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLAR 2599
SALD ESE IVQ+ALDKA GRT ++IAHRLSTI+NAD II C+NG+ +E G H+ L+A+
Sbjct: 583 SALDAESEGIVQQALDKAAKGRTTIIIAHRLSTIRNADLIISCKNGQVVEVGDHRALMAQ 642
Query: 2600 RGLYYRLVEKQS 2635
+GLYY LV Q+
Sbjct: 643 QGLYYDLVTAQT 654
>gi|17567269|ref|NP_510128.1| P-GlycoProtein related (146.8 kD)
(pgp-14) [Caenorhabditis elegans]
gi|7499665|pir||T21268 hypothetical protein F22E10.3 - Caenorhabditis
elegans
gi|3876293|emb|CAA91801.1| Hypothetical protein F22E10.3
[Caenorhabditis elegans]
gi|40764042|gb|AAR89639.1| P-glycoprotein related (146.8 kD) (pgp-14)
[Caenorhabditis elegans]
Length = 1327
Score = 692 bits (1786), Expect = 0.0
Identities = 385/893 (43%), Positives = 548/893 (61%), Gaps = 16/893 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
+ KIL G++ V PG +VALVGHSGCGKSTS+GLL R Y AG + +DG ++E NI W
Sbjct: 443 DAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEW 502
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR+T+GIVQQEPI+F T+ N+ +G+ T + + E CKMANAH+FI K+ YDT+IG
Sbjct: 503 LRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLIG 562
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
G VQLSGGQKQRVAIAR ++R P++LLLDEATSALD +SE +VQ+AL+ AS+GRTT+ I
Sbjct: 563 DGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMI 622
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIE---RAXXXXXXX 712
AHRLSTIR A KI+ F++G+I E G H+EL+ + G Y +VKAQ+ + A
Sbjct: 623 AHRLSTIREADKIVFFEKGVIVEAGNHEELV-RLGGRYFDLVKAQQFKADPEATEEFEEE 681
Query: 713 XXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXXX 892
RS R S+TS R ++ R ++ L S +
Sbjct: 682 EIDLDDTSRSSRRSSMTS--ARSGSEAFRRGNS-LNDSFSGSKRSAQADAENSAFAANEA 738
Query: 893 X-----GAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFK---ILSA 1048
G + A DIFK A + + VF LIRG PA ++++G +F+ +
Sbjct: 739 AIMAEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPY 798
Query: 1049 GGDDVSIKALLNSLWFILLAFTG-----GISTLISGSLLGKAGETMSGRLRMDVFRNIMQ 1213
GG +++ + ++AF S L S L E +S R R+ FRN++
Sbjct: 799 GG------RMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLY 852
Query: 1214 QDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMA 1393
QDASYFD+ H G L +RLA+DAPN++A +D R+ +V+ + ++ + +AF Y W +
Sbjct: 853 QDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVIYALAAIIANIAIAFIYCWQIG 912
Query: 1394 PIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYD 1573
+G + + + +A R+ E I N KT+Q LT+ E +D
Sbjct: 913 ILGTSLILLLAFVMIGLAYKISLMNVEQIQND-DAGRIAIEIIENVKTIQLLTRCELFFD 971
Query: 1574 AFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVI 1753
+ +SK R + +G+ ++++++L SF+ + Y G+ +I + F+ I
Sbjct: 972 HYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGI 1031
Query: 1754 EALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRG 1933
A+ + +++VM +A YFPE+V+A+ +AG++F +I +K + + GD P I+GNI
Sbjct: 1032 IAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDL-MEGDRPEIRGNILFEN 1090
Query: 1934 VYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDS 2113
V F+YP R Q ++ G +A GQTVALVGPSG GKST I ++ER+YD G+++ID
Sbjct: 1091 VKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQ 1150
Query: 2114 DIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGL 2293
DIR LS+ HLR +ALVGQEP LF TIREN+ GL+++ +++ +A LAN + F+ L
Sbjct: 1151 DIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANL 1210
Query: 2294 PDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKA 2473
P G DT VG GG+LSGGQKQR+AIARA+VRDPKILLLDEATSALD+ESE+ VQEALD+A
Sbjct: 1211 PAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRA 1270
Query: 2474 RLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
R GRTC+ IAHRLS+IQN+D I+ GK E G H L+ ++G YY+L++KQ
Sbjct: 1271 REGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 1323
Score = 304 bits (779), Expect = 6e-81
Identities = 187/587 (31%), Positives = 305/587 (51%), Gaps = 9/587 (1%)
Frame = +2
Query: 899 AMEASLFDIFKYASP-EMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSA---GGDDVS 1066
A S+ +F+Y + + I + +I G + P ++V G++ L
Sbjct: 85 AQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFR 144
Query: 1067 IKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRH 1246
KA N F+ + I+ I + ++R ++++Q+A +FD ++
Sbjct: 145 NKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD--KN 202
Query: 1247 NVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXX 1426
+ G++T++L ++ I +L +L G L + VA+ Y W +A +
Sbjct: 203 HSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCC 262
Query: 1427 XXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHR 1606
+ +++ +A + ES+ +TVQA QE M + A + +
Sbjct: 263 ICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRK 322
Query: 1607 RAIVRGLWQSLSFALAGSFVMWNFAI---AYMFGLWLISNNW-STPYTVFQVIEALNMAS 1774
A+ +G W G F W F+ ++G +L+ +TP VF V+ ++ + +
Sbjct: 323 FAVWKGFWSGF---FGGLFFFWLFSFLGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGA 379
Query: 1775 MSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDT-PTIKGNINMRGVYFAYP 1951
+ L + + + AR+SA ++ I + ID G + G + V+F YP
Sbjct: 380 YFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYP 439
Query: 1952 NRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLS 2131
+R+ +L+G N+ G +VALVG SGCGKST++ L+ R Y+ G+V ID +D+R+L+
Sbjct: 440 SRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELN 499
Query: 2132 VKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDT 2311
++ LR+ + +V QEP LFN TI N+ G T++ + + +AN H F+ +P GYDT
Sbjct: 500 IEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDT 559
Query: 2312 SVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTC 2491
+G G +LSGGQKQRVAIAR ++RDPK+LLLDEATSALD +SE IVQ AL+ A GRT
Sbjct: 560 LIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTT 619
Query: 2492 VVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
++IAHRLSTI+ ADKI+ G +E G H+ L+ G Y+ LV+ Q
Sbjct: 620 IMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQ 666
>gi|39587988|emb|CAE57219.1| Hypothetical protein CBG00079
[Caenorhabditis briggsae]
Length = 1327
Score = 689 bits (1777), Expect = 0.0
Identities = 386/892 (43%), Positives = 548/892 (61%), Gaps = 15/892 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
E KIL G++ V PG +VALVGHSGCGKSTS+GLL R Y AG + +DG ++E NI W
Sbjct: 443 EAKILNGLNLTVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIDW 502
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR+ +GIVQQEPI+F T+ N+ +G+ T + + E CKMANAH+FI K+ YDT+IG
Sbjct: 503 LRNVVGIVQQEPILFNDTIHNNLLIGNPGATREKMIEVCKMANAHDFIEKMPKGYDTLIG 562
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
G VQLSGGQKQRVAIAR ++R P+ILLLDEATSALD +SE +VQ+AL+ A++GRTT+ I
Sbjct: 563 DGGVQLSGGQKQRVAIARTLIRDPKILLLDEATSALDAQSESVVQSALNNAAKGRTTIMI 622
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIE---RAXXXXXXX 712
AHRLSTIR A KI+ F++G+I E G H+EL+ G Y +VKAQ+ + A
Sbjct: 623 AHRLSTIREADKIVFFEKGVIVEAGNHEELVHLG-GRYFDLVKAQQFKADPEATEEFEEE 681
Query: 713 XXXXXXXHRSFHRDSVTS----DEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXX 880
RS R S+TS E + SL + R+S +
Sbjct: 682 EIDLDDNSRSSRRSSMTSARSGSEAFQRGNSLNDSFSGSRRSARADAEN--DAFAAHEAE 739
Query: 881 XXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFK---ILSAG 1051
G + A DIFK A + + VF LIRG PA ++++G +F+ + G
Sbjct: 740 VMAQDGQITAGYLDIFKNAKGNYIYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYG 799
Query: 1052 GDDVSIKALLNSLWFILLAFTG-----GISTLISGSLLGKAGETMSGRLRMDVFRNIMQQ 1216
G +++ + ++AF IS + S L E +S R R+ FRN++ Q
Sbjct: 800 G------RMMHRMAMAVIAFASVGVGVWISQVASSVLFAIVSENLSLRFRVQSFRNLLYQ 853
Query: 1217 DASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAP 1396
DASYFD+ H G L +RLA+DAPN++A +D R+ +V+ + ++ + +AF Y W +A
Sbjct: 854 DASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVIYALAAIIANIVIAFIYCWQVAI 913
Query: 1397 IGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDA 1576
+G + + + EA R E I N KT+Q LT+ E +D
Sbjct: 914 LGTSLILLLAFVMIGLAYKISLMNIEQIKND-EAGRTAIEIIENVKTIQLLTRCELFFDH 972
Query: 1577 FTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIE 1756
+ +SK R + +G+ +++++++ SF+ + Y G+ +I + + F+ I
Sbjct: 973 YQTSSKQQKRSELKKGMIEAINYSITQSFMYFMMCFTYAVGIRVIYDGDKSSDVTFKGII 1032
Query: 1757 ALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGV 1936
++ + +++VM +A YFPE+V+A+ +AG++F +I +K + + GD P I+GNI V
Sbjct: 1033 SMMLGAVAVMNSAQYFPEFVKAKTAAGLLFNIIYRKPRTGDL-MEGDRPEIRGNILFENV 1091
Query: 1937 YFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSD 2116
F+YP R Q ++ G +A GQTVALVGPSG GKST I ++ER+YD G ++ID D
Sbjct: 1092 KFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGVLRIDGQD 1151
Query: 2117 IRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLP 2296
IR+LS+ HLR +ALVGQEP LF +IREN+ GL+++ +++ KA LAN + F+ LP
Sbjct: 1152 IRNLSLYHLRTQMALVGQEPRLFAGSIRENVCLGLKDVPLEKINKALELANANRFLANLP 1211
Query: 2297 DGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKAR 2476
G DT VG GG+LSGGQKQR+AIARA+VRDPKILLLDEATSALD+ESE+ VQEALD+AR
Sbjct: 1212 AGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAR 1271
Query: 2477 LGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
GRTC+ IAHRLS+IQN+D I+ GK E G H L+ ++G YY+L++KQ
Sbjct: 1272 EGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHAQLMQKKGRYYKLIKKQ 1323
Score = 301 bits (770), Expect = 7e-80
Identities = 186/587 (31%), Positives = 305/587 (51%), Gaps = 9/587 (1%)
Frame = +2
Query: 899 AMEASLFDIFKYASP-EMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSA---GGDDVS 1066
A S+ +F+Y + + I + +I G + P ++V G++ L
Sbjct: 85 AQPVSIPGLFRYGKRFDYLLLFIGTICAIISGVSQPIMALVSGRVTNALLVYPPTSKQFR 144
Query: 1067 IKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRH 1246
KA N F+ + I+ I + ++R ++++Q+A +FD ++
Sbjct: 145 NKANENVYIFLGIGIFISITNWIQYMCFQHCCSRVMAQMRHRFVYSVLRQNAGWFD--KN 202
Query: 1247 NVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXX 1426
+ G++T++L ++ I +L +L G L + VA+ Y W +A +
Sbjct: 203 HSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPVCC 262
Query: 1427 XXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHR 1606
+ +++ +A + ES+ +TVQA QE M + + R
Sbjct: 263 ICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYQTELEKGRR 322
Query: 1607 RAIVRGLWQSLSFALAGSFVMWNFAI---AYMFGLWLISNNW-STPYTVFQVIEALNMAS 1774
A+ +G W G F + F+ ++G +L+ +P VF V+ ++ + +
Sbjct: 323 FAVWKGFWSGF---FGGLFFLCLFSFLGTGMLYGAYLLKVGIIGSPGDVFIVVMSMLLGA 379
Query: 1775 MSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDT-PTIKGNINMRGVYFAYP 1951
+ L + + + AR+SA ++ I + ID G P + G + V+F YP
Sbjct: 380 YFLGLISPHMMVLLNARVSAATIYQTIDRVPKIDPYSKAGKRLPNVVGRVKFENVHFRYP 439
Query: 1952 NRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLS 2131
+R+ +L+G N++ G +VALVG SGCGKST++ L+ R Y+ G+V ID +D+R+L+
Sbjct: 440 SRKEAKILNGLNLTVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELN 499
Query: 2132 VKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDT 2311
+ LR+ + +V QEP LFN TI N+ G T++++ + +AN H F+ +P GYDT
Sbjct: 500 IDWLRNVVGIVQQEPILFNDTIHNNLLIGNPGATREKMIEVCKMANAHDFIEKMPKGYDT 559
Query: 2312 SVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTC 2491
+G G +LSGGQKQRVAIAR ++RDPKILLLDEATSALD +SE +VQ AL+ A GRT
Sbjct: 560 LIGDGGVQLSGGQKQRVAIARTLIRDPKILLLDEATSALDAQSESVVQSALNNAAKGRTT 619
Query: 2492 VVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
++IAHRLSTI+ ADKI+ G +E G H+ L+ G Y+ LV+ Q
Sbjct: 620 IMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVHLGGRYFDLVKAQ 666
>gi|72477|pir||DVHY1C multidrug resistance protein 1 - Chinese hamster
gi|191155|gb|AAA37004.1| p-glycoprotein
Length = 1276
Score = 675 bits (1741), Expect = 0.0
Identities = 377/890 (42%), Positives = 550/890 (61%), Gaps = 12/890 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
+++ILKG++ +V G+TVALVG+SGCGKST++ LL R Y+ G++ +DG I+ N+R+
Sbjct: 403 DVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIRTINVRY 462
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR IG+V QEP++F T+AENIR G +T +IE+A K ANA++FI KL ++DT++G
Sbjct: 463 LREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVG 522
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA EGRTT+ I
Sbjct: 523 ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVI 582
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ----EIERAXXXXXX 709
AHRLST+RNA I FD G+I E+G H+EL+ ++ GIY +V Q EIE
Sbjct: 583 AHRLSTVRNADIIAGFDGGVIVEQGNHEELM-REKGIYFKLVMTQTAGNEIELGNEVGES 641
Query: 710 XXXXXXXXHRSFHRDSVTSDEERELQQSLAR---DSTRLRQSMISTTTQVPXXXXXXXXX 880
S +DS +S R + R D R + + VP
Sbjct: 642 KNEIDNLDMSS--KDSASSLIRRRSTRRSIRGPHDQDRKLSTKEALDEDVP--------- 690
Query: 881 XXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDD 1060
S + I K S E ++ + ++ G PAFSI++ ++ + + DD
Sbjct: 691 --------PISFWRILKLNSSEWPYFVVGIFCAIVNGALQPAFSIIFSKVVGVFTRNTDD 742
Query: 1061 VSIK--ALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFD 1234
+ + + L SL F++L I+ + G GKAGE ++ RLR VF+++++QD S+FD
Sbjct: 743 ETKRHDSNLFSLLFLILGVISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFD 802
Query: 1235 DSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXX 1414
+ ++ G+LT+RLA DA V+ A RLA + I +L G+ ++ YGW + +
Sbjct: 803 NPKNTTGALTTRLANDAGQVKGATGARLAVITQNIANLGTGIIISLIYGWQLTLLLLAIV 862
Query: 1415 XXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASK 1594
L + +D + ++ TE+I N++TV +LT+++ + + + +
Sbjct: 863 PIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFENMYAQSLQ 922
Query: 1595 SPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMAS 1774
P+R A+ + ++F+ + + +++A + FG +L++ T V V A+ +
Sbjct: 923 IPYRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGA 982
Query: 1775 MSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYP 1951
M+V +S+ P+Y +A++SA + +I + ID+ G P T++GN+ V F YP
Sbjct: 983 MAVGQVSSFAPDYAKAKVSASHIIMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEVVFNYP 1042
Query: 1952 NRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLS 2131
R VL G N+ GQT+ALVG SGCGKST +QL+ER+YD + G+V +D ++ L+
Sbjct: 1043 TRPDIPVLQGLNLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEVNQLN 1102
Query: 2132 VKHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGY 2305
V+ LR ++ +V QEP LF+ +I ENI YG + ++QD++E+AA ANIH F+ LPD Y
Sbjct: 1103 VQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKY 1162
Query: 2306 DTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGR 2485
+T VG G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GR
Sbjct: 1163 NTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGR 1222
Query: 2486 TCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
TC+VIAHRLSTIQNAD I+V +NGK E GTHQ LLA++G+Y+ +V Q+
Sbjct: 1223 TCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQA 1272
Score = 342 bits (878), Expect = 2e-92
Identities = 212/598 (35%), Positives = 322/598 (53%), Gaps = 22/598 (3%)
Frame = +2
Query: 911 SLFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGD---------- 1057
S+F +F+YA + +++ + +I G P +V+G + ++ G+
Sbjct: 34 SVFTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLVFGDMTDSFASVGNIPTNATNNAT 93
Query: 1058 -----DVSIKALLNSLWFILLAFTG-GISTLISGSLLGKAGETMSGR----LRMDVFRNI 1207
D+ K L + +TG G LI + +GR +R F I
Sbjct: 94 QVNASDIFGK-LEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAI 152
Query: 1208 MQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWN 1387
M Q+ +FD H+VG L +RL D + I ++ + + F G + F GW
Sbjct: 153 MNQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWK 210
Query: 1388 MAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYM 1567
+ + L +++ + +A + E ++ +TV A Q+
Sbjct: 211 LTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKE 270
Query: 1568 YDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQ 1747
+ + + R I + + ++S A + ++A+A+ +G L+ + + V
Sbjct: 271 LERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLT 330
Query: 1748 VIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNIN 1924
V A+ +A S+ A+ + AR +A +F +I K ID+ G P IKGN+
Sbjct: 331 VFFAVLIAPFSIGQASPNIEAFANARGAAYEIFNIIDNKPSIDSFSKNGYKPDNIKGNLE 390
Query: 1925 MRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKI 2104
+ ++F+YP+R+ +L G N+ GQTVALVG SGCGKSTT+QL++R YD G V I
Sbjct: 391 FKNIHFSYPSRKDVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGVVSI 450
Query: 2105 DDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFV 2284
D DIR ++V++LR+ I +V QEP LF TI ENI YG EN+T D++EKA AN + F+
Sbjct: 451 DGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFI 510
Query: 2285 MGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEAL 2464
M LP +DT VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +VQ AL
Sbjct: 511 MKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAAL 570
Query: 2465 DKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
DKAR GRT +VIAHRLST++NAD I G +E+G H+ L+ +G+Y++LV Q++
Sbjct: 571 DKAREGRTTIVIAHRLSTVRNADIIAGFDGGVIVEQGNHEELMREKGIYFKLVMTQTA 628
>gi|126924|sp|P21448|MDR1_CRIGR Multidrug resistance protein 1
(P-glycoprotein 1)
gi|191165|gb|AAA68883.1| p-glycoprotein isoform I
Length = 1276
Score = 675 bits (1741), Expect = 0.0
Identities = 377/890 (42%), Positives = 550/890 (61%), Gaps = 12/890 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
+++ILKG++ +V G+TVALVG+SGCGKST++ LL R Y+ G++ +DG I+ N+R+
Sbjct: 403 DVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIRTINVRY 462
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR IG+V QEP++F T+AENIR G +T +IE+A K ANA++FI KL ++DT++G
Sbjct: 463 LREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVG 522
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA EGRTT+ I
Sbjct: 523 ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVI 582
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ----EIERAXXXXXX 709
AHRLST+RNA I FD G+I E+G H+EL+ ++ GIY +V Q EIE
Sbjct: 583 AHRLSTVRNADIIAGFDGGVIVEQGNHEELM-REKGIYFKLVMTQTAGNEIELGNEVGES 641
Query: 710 XXXXXXXXHRSFHRDSVTSDEERELQQSLAR---DSTRLRQSMISTTTQVPXXXXXXXXX 880
S +DS +S R + R D R + + VP
Sbjct: 642 KNEIDNLDMSS--KDSASSLIRRRSTRRSIRGPHDQDRKLSTKEALDEDVP--------- 690
Query: 881 XXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDD 1060
S + I K S E ++ + ++ G PAFSI++ ++ + + DD
Sbjct: 691 --------PISFWRILKLNSSEWPYFVVGIFCAIVNGALQPAFSIIFSKVVGVFTRNTDD 742
Query: 1061 VSIK--ALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFD 1234
+ + + L SL F++L I+ + G GKAGE ++ RLR VF+++++QD S+FD
Sbjct: 743 ETKRHDSNLFSLLFLILGVISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFD 802
Query: 1235 DSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXX 1414
+ ++ G+LT+RLA DA V+ A RLA + I +L G+ ++ YGW + +
Sbjct: 803 NPKNTTGALTTRLANDAGQVKGATGARLAVITQNIANLGTGIIISLIYGWQLTLLLLAIV 862
Query: 1415 XXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASK 1594
L + +D + ++ TE+I N++TV +LT+++ + + + +
Sbjct: 863 PIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFENMYAQSLQ 922
Query: 1595 SPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMAS 1774
P+R A+ + ++F+ + + +++A + FG +L++ T V V A+ +
Sbjct: 923 IPYRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGA 982
Query: 1775 MSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYP 1951
M+V +S+ P+Y +A++SA + +I + ID+ G P T++GN+ V F YP
Sbjct: 983 MAVGQVSSFAPDYAKAKVSASHIIMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEVVFNYP 1042
Query: 1952 NRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLS 2131
R VL G N+ GQT+ALVG SGCGKST +QL+ER+YD + G+V +D ++ L+
Sbjct: 1043 TRPDIPVLQGLNLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEVNQLN 1102
Query: 2132 VKHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGY 2305
V+ LR ++ +V QEP LF+ +I ENI YG + ++QD++E+AA ANIH F+ LPD Y
Sbjct: 1103 VQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKY 1162
Query: 2306 DTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGR 2485
+T VG G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GR
Sbjct: 1163 NTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGR 1222
Query: 2486 TCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
TC+VIAHRLSTIQNAD I+V +NGK E GTHQ LLA++G+Y+ +V Q+
Sbjct: 1223 TCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQA 1272
Score = 342 bits (876), Expect = 4e-92
Identities = 211/598 (35%), Positives = 322/598 (53%), Gaps = 22/598 (3%)
Frame = +2
Query: 911 SLFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGD---------- 1057
S+F +F+YA + +++ + +I G P +V+G + ++ G+
Sbjct: 34 SVFTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLVFGDMTDSFASVGNIPTNATNNAT 93
Query: 1058 -----DVSIKALLNSLWFILLAFTG-GISTLISGSLLGKAGETMSGR----LRMDVFRNI 1207
D+ K L + +TG G LI + +GR +R F I
Sbjct: 94 QVNASDIFGK-LEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAI 152
Query: 1208 MQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWN 1387
M Q+ +FD H+VG L +RL D + I ++ + + F G + F GW
Sbjct: 153 MNQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWK 210
Query: 1388 MAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYM 1567
+ + L +++ + +A + E ++ +TV A Q+
Sbjct: 211 LTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKE 270
Query: 1568 YDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQ 1747
+ + + R I + + ++S A + ++A+A+ +G L+ + + V
Sbjct: 271 LERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLT 330
Query: 1748 VIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNIN 1924
V A+ + + S+ A+ + AR +A +F +I K ID+ G P IKGN+
Sbjct: 331 VFFAVLIGAFSIGQASPNIEAFANARGAAYEIFNIIDNKPSIDSFSKNGYKPDNIKGNLE 390
Query: 1925 MRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKI 2104
+ ++F+YP+R+ +L G N+ GQTVALVG SGCGKSTT+QL++R YD G V I
Sbjct: 391 FKNIHFSYPSRKDVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGVVSI 450
Query: 2105 DDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFV 2284
D DIR ++V++LR+ I +V QEP LF TI ENI YG EN+T D++EKA AN + F+
Sbjct: 451 DGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFI 510
Query: 2285 MGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEAL 2464
M LP +DT VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +VQ AL
Sbjct: 511 MKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAAL 570
Query: 2465 DKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
DKAR GRT +VIAHRLST++NAD I G +E+G H+ L+ +G+Y++LV Q++
Sbjct: 571 DKAREGRTTIVIAHRLSTVRNADIIAGFDGGVIVEQGNHEELMREKGIYFKLVMTQTA 628
>gi|191157|gb|AAA37005.1| p-glycoprotein
Length = 1169
Score = 675 bits (1741), Expect = 0.0
Identities = 377/890 (42%), Positives = 550/890 (61%), Gaps = 12/890 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
+++ILKG++ +V G+TVALVG+SGCGKST++ LL R Y+ G++ +DG I+ N+R+
Sbjct: 296 DVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIRTINVRY 355
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR IG+V QEP++F T+AENIR G +T +IE+A K ANA++FI KL ++DT++G
Sbjct: 356 LREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVG 415
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA EGRTT+ I
Sbjct: 416 ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVI 475
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ----EIERAXXXXXX 709
AHRLST+RNA I FD G+I E+G H+EL+ ++ GIY +V Q EIE
Sbjct: 476 AHRLSTVRNADIIAGFDGGVIVEQGNHEELM-REKGIYFKLVMTQTAGNEIELGNEVGES 534
Query: 710 XXXXXXXXHRSFHRDSVTSDEERELQQSLAR---DSTRLRQSMISTTTQVPXXXXXXXXX 880
S +DS +S R + R D R + + VP
Sbjct: 535 KNEIDNLDMSS--KDSASSLIRRRSTRRSIRGPHDQDRKLSTKEALDEDVP--------- 583
Query: 881 XXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDD 1060
S + I K S E ++ + ++ G PAFSI++ ++ + + DD
Sbjct: 584 --------PISFWRILKLNSSEWPYFVVGIFCAIVNGALQPAFSIIFSKVVGVFTRNTDD 635
Query: 1061 VSIK--ALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFD 1234
+ + + L SL F++L I+ + G GKAGE ++ RLR VF+++++QD S+FD
Sbjct: 636 ETKRHDSNLFSLLFLILGVISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFD 695
Query: 1235 DSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXX 1414
+ ++ G+LT+RLA DA V+ A RLA + I +L G+ ++ YGW + +
Sbjct: 696 NPKNTTGALTTRLANDAGQVKGATGARLAVITQNIANLGTGIIISLIYGWQLTLLLLAIV 755
Query: 1415 XXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASK 1594
L + +D + ++ TE+I N++TV +LT+++ + + + +
Sbjct: 756 PIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFENMYAQSLQ 815
Query: 1595 SPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMAS 1774
P+R A+ + ++F+ + + +++A + FG +L++ T V V A+ +
Sbjct: 816 IPYRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGA 875
Query: 1775 MSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYP 1951
M+V +S+ P+Y +A++SA + +I + ID+ G P T++GN+ V F YP
Sbjct: 876 MAVGQVSSFAPDYAKAKVSASHIIMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEVVFNYP 935
Query: 1952 NRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLS 2131
R VL G N+ GQT+ALVG SGCGKST +QL+ER+YD + G+V +D ++ L+
Sbjct: 936 TRPDIPVLQGLNLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEVNQLN 995
Query: 2132 VKHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGY 2305
V+ LR ++ +V QEP LF+ +I ENI YG + ++QD++E+AA ANIH F+ LPD Y
Sbjct: 996 VQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKY 1055
Query: 2306 DTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGR 2485
+T VG G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GR
Sbjct: 1056 NTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGR 1115
Query: 2486 TCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
TC+VIAHRLSTIQNAD I+V +NGK E GTHQ LLA++G+Y+ +V Q+
Sbjct: 1116 TCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQA 1165
Score = 340 bits (873), Expect = 8e-92
Identities = 191/488 (39%), Positives = 282/488 (57%), Gaps = 1/488 (0%)
Frame = +2
Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
++R F IM Q+ +FD H+VG L +RL D + I ++ + + F G
Sbjct: 36 KIRQKFFHAIMNQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGG 93
Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
+ F GW + + L +++ + +A + E ++ +T
Sbjct: 94 FIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRT 153
Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
V A Q+ + + + R I + + ++S A + ++A+A+ +G L+ +
Sbjct: 154 VIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVIS 213
Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
+ V V A+ +A S+ A+ + AR +A +F +I K ID+ G
Sbjct: 214 KEYSIGQVLTVFFAVLIAPFSIGQASPNIEAFANARGAAYEIFNIIDNKPSIDSFSKNGY 273
Query: 1898 TP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
P IKGN+ + ++F+YP+R+ +L G N+ GQTVALVG SGCGKSTT+QL++R
Sbjct: 274 KPDNIKGNLEFKNIHFSYPSRKDVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRL 333
Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
YD G V ID DIR ++V++LR+ I +V QEP LF TI ENI YG EN+T D++EKA
Sbjct: 334 YDPTEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKA 393
Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
AN + F+M LP +DT VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDT
Sbjct: 394 VKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 453
Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
ESE +VQ ALDKAR GRT +VIAHRLST++NAD I G +E+G H+ L+ +G+Y+
Sbjct: 454 ESEAVVQAALDKAREGRTTIVIAHRLSTVRNADIIAGFDGGVIVEQGNHEELMREKGIYF 513
Query: 2615 RLVEKQSS 2638
+LV Q++
Sbjct: 514 KLVMTQTA 521
>gi|39595370|emb|CAE60408.1| Hypothetical protein CBG04013
[Caenorhabditis briggsae]
Length = 1265
Score = 673 bits (1737), Expect = 0.0
Identities = 369/879 (41%), Positives = 531/879 (59%), Gaps = 2/879 (0%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
++ +LKG+S EV GE +ALVG SGCGKST + LL RFY+ G + +DG+ ++E N+
Sbjct: 406 DIPVLKGISLEVKSGEKIALVGSSGCGKSTIVNLLQRFYDPTKGKVSIDGVDLKEINVHS 465
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR IGIV QEP++F T+ ENI+MG+ T + EACKMANA++FI +L D Y T +G
Sbjct: 466 LREQIGIVSQEPVLFDGTIYENIKMGNEHATHDQVVEACKMANANDFIKRLPDGYGTRVG 525
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
VQLSGGQKQR+AIARA+V+ P+ILLLDEATSALDTE+ER VQ ALD+A GRTTL +
Sbjct: 526 EKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQAALDQAQAGRTTLIV 585
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
AHRLSTIRN KI VF G I E G+H+EL++K G++ M +AQ + +
Sbjct: 586 AHRLSTIRNVDKIFVFKAGNIVETGSHEELMNK-QGVFYDMTQAQVVRQQQQEAGKDI-- 642
Query: 722 XXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXXXXGA 901
D+++ L + + STR SM ++ Q+ A
Sbjct: 643 ---------EDTISESAHSHLSR---KSSTRSAISMATSIHQL--------AEEVEECKA 682
Query: 902 MEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALL 1081
+ IF + ++ I + I G P F++VY ++F + S + +
Sbjct: 683 PPTPISKIFNFNRDKIWWFIGGMFGAFIFGSVTPVFALVYAEIFNVYSEPVEQMQSDVYF 742
Query: 1082 NSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSL 1261
F+L+ T I IS + LG+ GE+++ +LR + F+N+M+QD +++DD RH G L
Sbjct: 743 WCGMFVLMGITFFIGFFISANCLGRCGESLTMKLRFEAFKNLMRQDIAFYDDLRHGTGKL 802
Query: 1262 TSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXXX 1441
+R ATDAPNV+ + RL VL IV++ +G+ FYYGW +A I
Sbjct: 803 CTRFATDAPNVR-YVFTRLPVVLASIVTILGALGIGFYYGWQLALI-LVVMVPLLVMGGY 860
Query: 1442 XXXYLKFRGQ-RDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIV 1618
++F Q RD EA ++ ++++ + +TV +L +QE + + + P +
Sbjct: 861 FEMQMRFGKQIRDTQLLEEAGKVASQAVEHIRTVHSLNRQEQFHFTYCEYLREPFNTNLK 920
Query: 1619 RGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAAS 1798
FA + S + + +A+A+ G ++ + P V++V A++ + S
Sbjct: 921 HAHTYGAVFAFSQSLIFFMYAVAFYLGSIFVNQHSMQPIDVYRVFFAISFCGQMIGNTTS 980
Query: 1799 YFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVLD 1978
+ P+ V+AR++A ++F +I + ID+ G I GNI++R ++F YP R+ VL
Sbjct: 981 FIPDVVKARLAASLLFYLIEHPTPIDSLSEAGIVKPITGNISIRNIFFNYPTRKETKVLQ 1040
Query: 1979 GFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIA 2158
GF + GQTVALVG SGCGKST + L+ER+Y+ G + ID +IR+L++ LR +
Sbjct: 1041 GFTIDIKPGQTVALVGHSGCGKSTIMGLLERFYNQDKGMIMIDGDNIRNLNISSLRQQVC 1100
Query: 2159 LVGQEPTLFNLTIRENITYGL-ENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGR 2335
+V QEPTLF+ TI ENI YG N+T ++ +AA +ANIH F++GLPDGYDT VG G +
Sbjct: 1101 IVSQEPTLFDCTIGENICYGTNRNVTYQEIVEAAKMANIHNFILGLPDGYDTHVGEKGTQ 1160
Query: 2336 LSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLS 2515
LSGGQKQR+AIARA+VR P +LLLDEATSALDTESEKIVQEALD A+ GRTC+VIAHRLS
Sbjct: 1161 LSGGQKQRIAIARALVRSPSVLLLDEATSALDTESEKIVQEALDAAKQGRTCLVIAHRLS 1220
Query: 2516 TIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
TIQN+D I + GK +++GTH L+ + +Y +L E Q
Sbjct: 1221 TIQNSDVIAIVSEGKIVDKGTHDELMRKSEIYQKLCETQ 1259
Score = 325 bits (834), Expect = 3e-87
Identities = 192/596 (32%), Positives = 325/596 (54%), Gaps = 24/596 (4%)
Frame = +2
Query: 917 FDIFKYA-SPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKI---------------LSA 1048
+ +F Y ++ +I+ + +I G +P +IV G + + ++
Sbjct: 36 YGLFSYTRGKDLILLIVGTIAAVIHGAGFPLLAIVLGGMTTVFLRAQNSDFVVGVGNVNP 95
Query: 1049 GG------DDVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIM 1210
G D+ + + + +++++L +++ + + E + +LR + + I+
Sbjct: 96 NGLEPISIDEFNSEVVKYCIYYLILGVAMFVTSYVQIACFESYAENLVHKLRQNYLKAIL 155
Query: 1211 QQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNM 1390
+Q +FD + G+LT+RL D V+ + + A ++ + G GV F+Y W+M
Sbjct: 156 RQQIQWFD--KQQTGNLTARLTDDLERVREGLGDKFALLVQMFAAFLAGYGVGFFYSWSM 213
Query: 1391 APIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMY 1570
+ + R + + ++ A + E+ S+ +TV +L +
Sbjct: 214 TLVMMGFAPLIVLSGAKMSKSMATRTKVEQETYAVAGAIAEETFSSIRTVHSLNGHKREL 273
Query: 1571 DAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPY-TVFQ 1747
D F A ++ + IV+ + + + + ++A+A+ +G LI N+ + +F
Sbjct: 274 DRFWNALENGRKTGIVKYCYMGIGVGFSNLCMYSSYALAFWYGSTLIINDPTFDRGLIFT 333
Query: 1748 VIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD-TPTIKGNIN 1924
V A+ S S+ A + + AR +A + +I ID L G +KG+I+
Sbjct: 334 VFFAVLSGSTSLGGALPHLASFGTARGAAYTVLRVINSHPKIDPYSLEGLLVDNMKGDIS 393
Query: 1925 MRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKI 2104
+ V+F YP+R+ VL G ++ G+ +ALVG SGCGKST + L++R+YD G V I
Sbjct: 394 FQNVHFRYPSRKDIPVLKGISLEVKSGEKIALVGSSGCGKSTIVNLLQRFYDPTKGKVSI 453
Query: 2105 DDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFV 2284
D D+++++V LR+ I +V QEP LF+ TI ENI G E+ T DQV +A +AN + F+
Sbjct: 454 DGVDLKEINVHSLREQIGIVSQEPVLFDGTIYENIKMGNEHATHDQVVEACKMANANDFI 513
Query: 2285 MGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEAL 2464
LPDGY T VG G +LSGGQKQR+AIARA+V++PKILLLDEATSALDTE+E+ VQ AL
Sbjct: 514 KRLPDGYGTRVGEKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQAAL 573
Query: 2465 DKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
D+A+ GRT +++AHRLSTI+N DKI V + G +E G+H+ L+ ++G++Y + + Q
Sbjct: 574 DQAQAGRTTLIVAHRLSTIRNVDKIFVFKAGNIVETGSHEELMNKQGVFYDMTQAQ 629
>gi|22759019|gb|AAN05645.1| multidrug resistance p-glycoprotein [Canis
familiaris]
Length = 1281
Score = 673 bits (1737), Expect = 0.0
Identities = 377/889 (42%), Positives = 547/889 (61%), Gaps = 11/889 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
E+KILKG++ +V G+TVALVG+SGCGKST++ L+ R Y+ GM+ +DG I+ N+R
Sbjct: 408 EVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTDGMVCIDGQDIRTINVRH 467
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR G+V QEP++F T+AENIR G +T +IE+A K ANA++FI KL +++DT++G
Sbjct: 468 LREITGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPNKFDTLVG 527
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA +GRTT+ I
Sbjct: 528 ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVI 587
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ------EIERAXXXX 703
AHRLST+RNA I FD G+I E+G HDEL+ K+ GIY +V Q E+E A
Sbjct: 588 AHRLSTVRNADVIAGFDDGVIVEKGNHDELM-KEKGIYFKLVTMQTRGNEIELENATG-- 644
Query: 704 XXXXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXX 883
+S + + E+ + S R+S +
Sbjct: 645 ----------------ESKSESDALEMSPKDSGSSLIKRRSTRRSIHAPQGQDRKLGTKE 688
Query: 884 XXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV 1063
S + I K S E ++ + +I G PAFSI++ ++ I + D
Sbjct: 689 DLNENVPPVSFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSIIFSRIIGIFTRDEDPE 748
Query: 1064 SIKALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDD 1237
+ + N S+ F++L I+ + G GKAGE ++ RLR VFR++++QD S+FDD
Sbjct: 749 TKRQNSNMFSVLFLVLGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDD 808
Query: 1238 SRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXX 1417
++ G+LT+RLA DA V+ AI RLA + I +L G+ ++ YGW + +
Sbjct: 809 PKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVP 868
Query: 1418 XXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKS 1597
L + +D A ++ TE+I N++TV +LT+++ + + +
Sbjct: 869 IIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTREQKFEYMYAQSLQV 928
Query: 1598 PHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASM 1777
P+R ++ + +SF++ + + +++A + FG +L++N + V V A+ +M
Sbjct: 929 PYRNSLRKAHIFGVSFSITQAMMYFSYAGCFRFGAYLVANEFMNFQDVLLVFSAIVFGAM 988
Query: 1778 SVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYPN 1954
+V +S+ P+Y +A++SA + +I + +ID+ G P T++GN+ V F YP
Sbjct: 989 AVGQVSSFAPDYAKAKVSAAHVIMIIEKSPLIDSYSPHGLKPNTLEGNVTFNEVVFNYPT 1048
Query: 1955 RRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSV 2134
R VL G ++ GQT+ALVG SGCGKST +QL+ER+YD L GSV ID +I+ L+V
Sbjct: 1049 RPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGSVLIDGKEIKHLNV 1108
Query: 2135 KHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYD 2308
+ LR ++ +V QEP LF+ +I ENI YG + ++ +++ +AA ANIH F+ LP+ Y+
Sbjct: 1109 QWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIMQAAKEANIHHFIETLPEKYN 1168
Query: 2309 TSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRT 2488
T VG G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GRT
Sbjct: 1169 TRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRT 1228
Query: 2489 CVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
C+VIAHRLSTIQNAD I+V +NGK E GTHQ LLA++G+Y+ +V Q+
Sbjct: 1229 CIVIAHRLSTIQNADLIVVFQNGKVKEHGTHQQLLAQKGIYFSMVSVQA 1277
Score = 340 bits (871), Expect = 1e-91
Identities = 191/487 (39%), Positives = 283/487 (57%), Gaps = 1/487 (0%)
Frame = +2
Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
++R F IM+Q+ +FD H+VG L +RL D + I ++ I + F G
Sbjct: 148 KIRKQFFHAIMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFHSIATFFTG 205
Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
V F GW + + L +++ + +A + E ++ +T
Sbjct: 206 FIVGFTRGWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAYAKAGAVAEEVLAAIRT 265
Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
V A Q+ + + + I + + ++S A + ++A+A+ +G L+ +
Sbjct: 266 VIAFGGQKKELERYNKNLEEAKGIGIKKAITANISIGAAFLLIYASYALAFWYGTSLVLS 325
Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
+ + V V ++ + + S+ A+ + AR +A +F +I K ID+ +G
Sbjct: 326 SEYSIGQVLTVFFSVLIGAFSIGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGH 385
Query: 1898 TP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
P IKGN+ + V+F+YP+R+ +L G N+ GQTVALVG SGCGKSTT+QL++R
Sbjct: 386 KPDNIKGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRL 445
Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
YD G V ID DIR ++V+HLR+ +V QEP LF TI ENI YG EN+T D++EKA
Sbjct: 446 YDPTDGMVCIDGQDIRTINVRHLREITGVVSQEPVLFATTIAENIRYGRENVTMDEIEKA 505
Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
AN + F+M LP+ +DT VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDT
Sbjct: 506 VKEANAYDFIMKLPNKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 565
Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
ESE +VQ ALDKAR GRT +VIAHRLST++NAD I +G +E+G H L+ +G+Y+
Sbjct: 566 ESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYF 625
Query: 2615 RLVEKQS 2635
+LV Q+
Sbjct: 626 KLVTMQT 632
>gi|46394982|gb|AAS91647.1| multidrug resistance protein 1;
P-glycoprotein [Canis familiaris]
Length = 1281
Score = 673 bits (1737), Expect = 0.0
Identities = 377/889 (42%), Positives = 547/889 (61%), Gaps = 11/889 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
E+KILKG++ +V G+TVALVG+SGCGKST++ L+ R Y+ GM+ +DG I+ N+R
Sbjct: 408 EVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTDGMVCIDGQDIRTINVRH 467
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR G+V QEP++F T+AENIR G +T +IE+A K ANA++FI KL +++DT++G
Sbjct: 468 LREITGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPNKFDTLVG 527
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA +GRTT+ I
Sbjct: 528 ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVI 587
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ------EIERAXXXX 703
AHRLST+RNA I FD G+I E+G HDEL+ K+ GIY +V Q E+E A
Sbjct: 588 AHRLSTVRNADVIAGFDDGVIVEKGNHDELM-KEKGIYFKLVTMQTRGNEIELENATG-- 644
Query: 704 XXXXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXX 883
+S + + E+ + S R+S +
Sbjct: 645 ----------------ESKSESDALEMSPKDSGSSLIKRRSTRRSIHAPQGQDRKLGTKE 688
Query: 884 XXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV 1063
S + I K S E ++ + +I G PAFSI++ ++ I + D
Sbjct: 689 DLNENVPPVSFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSIIFSRIIGIFTRDEDPE 748
Query: 1064 SIKALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDD 1237
+ + N S+ F++L I+ + G GKAGE ++ RLR VFR++++QD S+FDD
Sbjct: 749 TKRQNSNMFSVLFLVLGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDD 808
Query: 1238 SRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXX 1417
++ G+LT+RLA DA V+ AI RLA + I +L G+ ++ YGW + +
Sbjct: 809 PKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVP 868
Query: 1418 XXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKS 1597
L + +D A ++ TE+I N++TV +LT+++ + + +
Sbjct: 869 IIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTREQKFEYMYAQSLQV 928
Query: 1598 PHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASM 1777
P+R ++ + +SF++ + + +++A + FG +L++N + V V A+ +M
Sbjct: 929 PYRNSLRKAHIFGVSFSITQAMMYFSYAGCFRFGAYLVANEFMNFQDVLLVFSAIVFGAM 988
Query: 1778 SVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYPN 1954
+V +S+ P+Y +A++SA + +I + +ID+ G P T++GN+ V F YP
Sbjct: 989 AVGQVSSFAPDYAKAKVSAAHVIMIIEKSPLIDSYSPHGLKPNTLEGNVTFNEVVFNYPT 1048
Query: 1955 RRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSV 2134
R VL G ++ GQT+ALVG SGCGKST +QL+ER+YD L GSV ID +I+ L+V
Sbjct: 1049 RPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGSVLIDGKEIKHLNV 1108
Query: 2135 KHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYD 2308
+ LR ++ +V QEP LF+ +I ENI YG + ++ +++ +AA ANIH F+ LP+ Y+
Sbjct: 1109 QWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIVQAAKEANIHHFIETLPEKYN 1168
Query: 2309 TSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRT 2488
T VG G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GRT
Sbjct: 1169 TRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRT 1228
Query: 2489 CVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
C+VIAHRLSTIQNAD I+V +NGK E GTHQ LLA++G+Y+ +V Q+
Sbjct: 1229 CIVIAHRLSTIQNADLIVVFQNGKVKEHGTHQQLLAQKGIYFSMVSVQA 1277
Score = 343 bits (879), Expect = 2e-92
Identities = 192/487 (39%), Positives = 284/487 (57%), Gaps = 1/487 (0%)
Frame = +2
Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
++R F IM+Q+ +FD H+VG L +RL D + I ++ I + F G
Sbjct: 148 KIRKQFFHAIMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQSIATFFTG 205
Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
V F GW + + L +++ + +A + E ++ +T
Sbjct: 206 FIVGFTRGWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAYAKAGAVAEEVLAAIRT 265
Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
V A Q+ + + + R I + + ++S A + ++A+A+ +G L+ +
Sbjct: 266 VIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTSLVLS 325
Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
+ + V V ++ + + S+ A+ + AR +A +F +I K ID+ +G
Sbjct: 326 SEYSIGQVLTVFFSVLIGAFSIGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGH 385
Query: 1898 TP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
P IKGN+ + V+F+YP+R+ +L G N+ GQTVALVG SGCGKSTT+QL++R
Sbjct: 386 KPDNIKGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRL 445
Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
YD G V ID DIR ++V+HLR+ +V QEP LF TI ENI YG EN+T D++EKA
Sbjct: 446 YDPTDGMVCIDGQDIRTINVRHLREITGVVSQEPVLFATTIAENIRYGRENVTMDEIEKA 505
Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
AN + F+M LP+ +DT VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDT
Sbjct: 506 VKEANAYDFIMKLPNKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 565
Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
ESE +VQ ALDKAR GRT +VIAHRLST++NAD I +G +E+G H L+ +G+Y+
Sbjct: 566 ESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYF 625
Query: 2615 RLVEKQS 2635
+LV Q+
Sbjct: 626 KLVTMQT 632
>gi|8926217|gb|AAF81747.1| his-tagged-multidrug resistance
glycoprotein MDR1 [synthetic construct]
Length = 1287
Score = 673 bits (1736), Expect = 0.0
Identities = 376/889 (42%), Positives = 547/889 (61%), Gaps = 11/889 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
E+KILKG++ +V G+TVALVG+SGCGKST++ L+ R Y+ GM+ +DG I+ N+R
Sbjct: 414 EVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTDGMVCIDGQDIRTINVRH 473
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR G+V QEP++F T+AENIR G +T +IE+A K ANA++FI KL +++DT++G
Sbjct: 474 LREITGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPNKFDTLVG 533
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA +GRTT+ I
Sbjct: 534 ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVI 593
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ------EIERAXXXX 703
AHRLST+RNA I FD G+I E+G HDEL+ K+ GIY +V Q E+E A
Sbjct: 594 AHRLSTVRNADVIAGFDDGVIVEKGNHDELM-KEKGIYFKLVTMQTRGNEIELENATG-- 650
Query: 704 XXXXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXX 883
+S + + E+ + S R+S +
Sbjct: 651 ----------------ESKSESDALEMSPKDSGSSLIKRRSTRRSIHAPQGQDRKLGTKE 694
Query: 884 XXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV 1063
S + I K S E ++ + +I G PAFSI++ ++ I + D
Sbjct: 695 DLNENVPPVSFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSIIFSRIIGIFTRDEDPE 754
Query: 1064 SIKALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDD 1237
+ + N S+ F++L I+ + G GKAGE ++ RLR VFR++++QD S+FDD
Sbjct: 755 TKRQNSNMFSVLFLVLGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDD 814
Query: 1238 SRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXX 1417
++ G+LT+RLA DA V+ AI RLA + I +L G+ ++ YGW + +
Sbjct: 815 PKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVP 874
Query: 1418 XXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKS 1597
L + +D A ++ TE+I N++TV +LT+++ + + +
Sbjct: 875 IIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTREQKFEYMYAQSLQV 934
Query: 1598 PHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASM 1777
P+R ++ + +SF++ + + +++A + FG +L++N + V V A+ +M
Sbjct: 935 PYRNSLRKAHIFGVSFSITQAMMYFSYAGCFRFGAYLVANEFMNFQDVLLVFSAIVFGAM 994
Query: 1778 SVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYPN 1954
+V +S+ P+Y +A++SA + +I + +ID+ G P T++GN+ V F YP
Sbjct: 995 AVGQVSSFAPDYAKAKVSAAHVIMIIEKSPLIDSYSPHGLKPNTLEGNVTFNEVVFNYPT 1054
Query: 1955 RRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSV 2134
R VL G ++ GQT+ALVG SGCGKST +QL+ER+YD L GSV ID +I+ L+V
Sbjct: 1055 RPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGSVLIDGKEIKHLNV 1114
Query: 2135 KHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYD 2308
+ LR ++ +V QEP LF+ +I ENI YG + ++ +++ +AA ANIH F+ LP+ Y+
Sbjct: 1115 QWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIMQAAKEANIHHFIETLPEKYN 1174
Query: 2309 TSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRT 2488
T VG G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GRT
Sbjct: 1175 TRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRT 1234
Query: 2489 CVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
C+VIAHRLSTIQNAD I+V +NGK E GTHQ LLA++G+Y+ ++ Q+
Sbjct: 1235 CIVIAHRLSTIQNADLIVVFQNGKVKEHGTHQQLLAQKGIYFSMISVQA 1283
Score = 343 bits (879), Expect = 2e-92
Identities = 192/487 (39%), Positives = 284/487 (57%), Gaps = 1/487 (0%)
Frame = +2
Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
++R F IM+Q+ +FD H+VG L +RL D + I ++ I + F G
Sbjct: 154 KIRKQFFHAIMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQSIATFFTG 211
Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
V F GW + + L +++ + +A + E ++ +T
Sbjct: 212 FIVGFTRGWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAYAKAGAVAEEVLAAIRT 271
Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
V A Q+ + + + R I + + ++S A + ++A+A+ +G L+ +
Sbjct: 272 VIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTSLVLS 331
Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
+ + V V ++ + + S+ A+ + AR +A +F +I K ID+ +G
Sbjct: 332 SEYSIGQVLTVFFSVLIGAFSIGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGH 391
Query: 1898 TP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
P IKGN+ + V+F+YP+R+ +L G N+ GQTVALVG SGCGKSTT+QL++R
Sbjct: 392 KPDNIKGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRL 451
Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
YD G V ID DIR ++V+HLR+ +V QEP LF TI ENI YG EN+T D++EKA
Sbjct: 452 YDPTDGMVCIDGQDIRTINVRHLREITGVVSQEPVLFATTIAENIRYGRENVTMDEIEKA 511
Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
AN + F+M LP+ +DT VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDT
Sbjct: 512 VKEANAYDFIMKLPNKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 571
Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
ESE +VQ ALDKAR GRT +VIAHRLST++NAD I +G +E+G H L+ +G+Y+
Sbjct: 572 ESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYF 631
Query: 2615 RLVEKQS 2635
+LV Q+
Sbjct: 632 KLVTMQT 638
>gi|17508505|ref|NP_491707.1| P-GlycoProtein related (pgp-2)
[Caenorhabditis elegans]
gi|15617726|gb|AAB52482.2| P-glycoprotein related protein 2
[Caenorhabditis elegans]
Length = 1265
Score = 672 bits (1735), Expect = 0.0
Identities = 369/879 (41%), Positives = 531/879 (59%), Gaps = 2/879 (0%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
++ +LKG+S E+ G+ +ALVG SGCGKST + LL RFY+ G + +DG+ ++E N+
Sbjct: 406 DIHVLKGISLELKAGDKIALVGSSGCGKSTIVNLLQRFYDPTKGRVLIDGVDLREVNVHS 465
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR IGIV QEP++F T+ ENI+MG+ T + EACKMANA++FI +L D Y T +G
Sbjct: 466 LREQIGIVSQEPVLFDGTIYENIKMGNEHATHDQVVEACKMANANDFIKRLPDGYGTRVG 525
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
VQLSGGQKQR+AIARA+V+ P+ILLLDEATSALDTE+ER VQ ALD+A GRTT+ +
Sbjct: 526 EKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQGALDQAQAGRTTIIV 585
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
AHRLSTIRN +I VF G I E G+H+EL+SK GI+ M +AQ + +
Sbjct: 586 AHRLSTIRNVDRIFVFKAGNIVESGSHEELMSK-QGIFYDMTQAQVVRQQQQEAGKDI-- 642
Query: 722 XXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXXXXGA 901
D+++ L + + STR S IS T + A
Sbjct: 643 ---------EDTISESAHSHLSR---KSSTR---SAISIATSI-----HQLAEEVEECKA 682
Query: 902 MEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALL 1081
S+F IFK+ ++ I + I G P F++VY ++F + S D +
Sbjct: 683 PPTSMFKIFKFNGDKVGWFIGGIFGAFIFGSVTPVFALVYAEIFNVYSLPADQMQANVYF 742
Query: 1082 NSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSL 1261
F+L+ T + S + LG+ GE+++ +LR + F+N+++QD +++DD RH G L
Sbjct: 743 WCGMFVLMGITFFVGFFTSANCLGRCGESLTMKLRFEAFKNLLRQDIAFYDDLRHGTGKL 802
Query: 1262 TSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXXX 1441
+R ATDAPNV+ + RL VL IV++ +G+ FYYGW +A I
Sbjct: 803 CTRFATDAPNVR-YVFTRLPVVLASIVTICGALGIGFYYGWQLALI-LVVMVPLLVMGGY 860
Query: 1442 XXXYLKFRGQ-RDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIV 1618
++F Q RD EA ++ ++++ + +TV +L +QE + + + P +
Sbjct: 861 FEMQMRFGKQIRDTQLLEEAGKVASQAVEHIRTVHSLNRQEQFHFTYCEYLREPFNTNLK 920
Query: 1619 RGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAAS 1798
FA + S + + +A A+ G ++ P V++V A++ + S
Sbjct: 921 HAHTYGAVFAFSQSLIFFMYAAAFYLGSIFVNQQAMQPIDVYRVFFAISFCGQMIGNTTS 980
Query: 1799 YFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVLD 1978
+ P+ V+AR++A ++F +I + ID+ +G I GNI++R V+F YP R+ VL
Sbjct: 981 FIPDVVKARLAASLLFYLIEHPTPIDSLSDSGIVKPITGNISIRNVFFNYPTRKDTKVLQ 1040
Query: 1979 GFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIA 2158
GF + G+TVALVG SGCGKST + L+ER+Y+ G + ID +IR+L++ LR+ +
Sbjct: 1041 GFTLDIKAGKTVALVGHSGCGKSTIMGLLERFYNQDKGMIMIDGDNIRNLNISSLREQVC 1100
Query: 2159 LVGQEPTLFNLTIRENITYGL-ENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGR 2335
+V QEPTLF+ TI ENI YG N+T ++ +AA +ANIH F++GLPDGYDT VG G +
Sbjct: 1101 IVSQEPTLFDCTIGENICYGTNRNVTYQEIVEAAKMANIHNFILGLPDGYDTHVGEKGTQ 1160
Query: 2336 LSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLS 2515
LSGGQKQR+AIARA+VR P +LLLDEATSALDTESEKIVQEALD A+ GRTC+VIAHRLS
Sbjct: 1161 LSGGQKQRIAIARALVRSPSVLLLDEATSALDTESEKIVQEALDAAKQGRTCLVIAHRLS 1220
Query: 2516 TIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
TIQN+D I + GK +E+GTH L+ + +Y + E Q
Sbjct: 1221 TIQNSDVIAIVSEGKIVEKGTHDELIRKSEIYQKFCETQ 1259
Score = 323 bits (829), Expect = 1e-86
Identities = 198/596 (33%), Positives = 324/596 (54%), Gaps = 24/596 (4%)
Frame = +2
Query: 917 FDIFKYASP-EMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILS--------AGGDDVSI 1069
+ IF Y ++ +I V +I G +P +IV G + + G D+V+
Sbjct: 36 YGIFYYTQGVDLLLLITGTVAAVIHGAGFPLLAIVLGGMTTVFLRAQNSDFVVGVDNVNP 95
Query: 1070 KALL-------NS------LWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIM 1210
+ L+ NS +++++L ++ + + E + +LR + + I+
Sbjct: 96 EGLVPISLDEFNSEVVKYCIYYLVLGVLMFFTSYVQIACFESYAERLVHKLRQNYLKAIL 155
Query: 1211 QQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNM 1390
+Q +FD + G+LT+RL D V+ + + A ++ + G GV F+Y W+M
Sbjct: 156 RQQIQWFD--KQQTGNLTARLTDDLERVREGLGDKFALLVQMFAAFLAGYGVGFFYSWSM 213
Query: 1391 APIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMY 1570
+ + R + + ++ A + E+ S+ +TV +L +
Sbjct: 214 TLVMMGFAPLIVLSGAKMSKSMATRTRVEQETYAVAGAIAEETFSSIRTVHSLNGHKREL 273
Query: 1571 DAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPY-TVFQ 1747
D F A + + IV+ + + + + ++A+A+ +G LI N+ + +F
Sbjct: 274 DRFYNALEVGRQTGIVKYCYMGIGVGFSNLCMYSSYALAFWYGSTLIINDPTFDRGLIFT 333
Query: 1748 VIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD-TPTIKGNIN 1924
V A+ S S+ A + + AR +A + +I ID L G +KG+I+
Sbjct: 334 VFFAVLSGSTSLGGALPHLASFGTARGAASTVLRVINSHPKIDPYSLEGILVDNMKGDIS 393
Query: 1925 MRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKI 2104
+ V+F YP+R+ VL G ++ G +ALVG SGCGKST + L++R+YD G V I
Sbjct: 394 FKDVHFRYPSRKDIHVLKGISLELKAGDKIALVGSSGCGKSTIVNLLQRFYDPTKGRVLI 453
Query: 2105 DDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFV 2284
D D+R+++V LR+ I +V QEP LF+ TI ENI G E+ T DQV +A +AN + F+
Sbjct: 454 DGVDLREVNVHSLREQIGIVSQEPVLFDGTIYENIKMGNEHATHDQVVEACKMANANDFI 513
Query: 2285 MGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEAL 2464
LPDGY T VG G +LSGGQKQR+AIARA+V++PKILLLDEATSALDTE+E+ VQ AL
Sbjct: 514 KRLPDGYGTRVGEKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQGAL 573
Query: 2465 DKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
D+A+ GRT +++AHRLSTI+N D+I V + G +E G+H+ L++++G++Y + + Q
Sbjct: 574 DQAQAGRTTIIVAHRLSTIRNVDRIFVFKAGNIVESGSHEELMSKQGIFYDMTQAQ 629
>gi|307180|gb|AAA59575.1| P-glycoprotein [Homo sapiens]
Length = 1280
Score = 672 bits (1734), Expect = 0.0
Identities = 374/889 (42%), Positives = 547/889 (61%), Gaps = 11/889 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
E+KILKG++ +V G+TVALVG+SGCGKST++ L+ R Y+ GM+ +DG I+ N+R+
Sbjct: 406 EVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRF 465
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR IG+V QEP++F T+AENIR G +T +IE+A K ANA++FI KL ++DT++G
Sbjct: 466 LREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVG 525
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA +GRTT+ I
Sbjct: 526 ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVI 585
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ------EIERAXXXX 703
AHRLST+RNA I FD G+I E+G HDEL+ K+ GIY +V Q E+E A
Sbjct: 586 AHRLSTVRNADVIAGFDDGVIVEKGNHDELM-KEKGIYFKLVTMQTAGNEVELENAAD-- 642
Query: 704 XXXXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXX 883
+S + + E+ + +R S ++S +
Sbjct: 643 ----------------ESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKE 686
Query: 884 XXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV 1063
S + I K E ++ + +I G PAF+I++ ++ + + D
Sbjct: 687 ALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPE 746
Query: 1064 SIKALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDD 1237
+ + N SL F+ L I+ + G GKAGE ++ RLR VFR++++QD S+FDD
Sbjct: 747 TKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDD 806
Query: 1238 SRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXX 1417
++ G+LT+RLA DA V+ AI RLA + I +L G+ ++F YGW + +
Sbjct: 807 PKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVP 866
Query: 1418 XXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKS 1597
L + +D A ++ TE+I N++TV +LT+++ + + +
Sbjct: 867 IIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQV 926
Query: 1598 PHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASM 1777
P+R ++ + ++F+ + + +++A + FG +L+++ + V V A+ +M
Sbjct: 927 PYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAM 986
Query: 1778 SVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYPN 1954
+V +S+ P+Y +A+ISA + +I + +ID+ G P T++GN+ V F YP
Sbjct: 987 AVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPT 1046
Query: 1955 RRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSV 2134
R VL G ++ GQT+ALVG SGCGKST +QL+ER+YD L G V +D +I+ L+V
Sbjct: 1047 RPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNV 1106
Query: 2135 KHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYD 2308
+ LR ++ +V QEP LF+ +I ENI YG + ++Q+++ +AA ANIH F+ LP+ Y
Sbjct: 1107 QWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYS 1166
Query: 2309 TSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRT 2488
T VG G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GRT
Sbjct: 1167 TKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRT 1226
Query: 2489 CVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
C+VIAHRLSTIQNAD I+V +NG+ E GTHQ LLA++G+Y+ +V Q+
Sbjct: 1227 CIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1275
Score = 348 bits (893), Expect = 4e-94
Identities = 210/599 (35%), Positives = 330/599 (55%), Gaps = 23/599 (3%)
Frame = +2
Query: 911 SLFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGD------DVSI 1069
S+F +F+Y++ + +++ + +I G P +V+G++ I + G+ +++
Sbjct: 35 SVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITN 94
Query: 1070 KALLNSLWFIL----------LAFTG-GISTLISGSLLGKAGETMSGR----LRMDVFRN 1204
++ +N F + ++G G L++ + +GR +R F
Sbjct: 95 RSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHA 154
Query: 1205 IMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGW 1384
IM+Q+ +FD H+VG L +RL D + I ++ + + F G V F GW
Sbjct: 155 IMRQEIGWFDV--HDVGELNTRLTDDVSKINEVIGDKIGMFFQSMATFFTGFIVGFTRGW 212
Query: 1385 NMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEY 1564
+ + L +++ + +A + E ++ +TV A Q+
Sbjct: 213 KLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKK 272
Query: 1565 MYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVF 1744
+ + + R I + + ++S A + ++A+A+ +G L+ + + V
Sbjct: 273 ELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVL 332
Query: 1745 QVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNI 1921
V ++ + + SV A+ + AR +A +F +I K ID+ +G P IKGN+
Sbjct: 333 TVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNL 392
Query: 1922 NMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVK 2101
R V+F+YP+R+ +L G N+ GQTVALVG SGCGKSTT+QL++R YD G V
Sbjct: 393 EFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVS 452
Query: 2102 IDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTF 2281
+D DIR ++V+ LR+ I +V QEP LF TI ENI YG EN+T D++EKA AN + F
Sbjct: 453 VDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDF 512
Query: 2282 VMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEA 2461
+M LP +DT VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +VQ A
Sbjct: 513 IMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVA 572
Query: 2462 LDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
LDKAR GRT +VIAHRLST++NAD I +G +E+G H L+ +G+Y++LV Q++
Sbjct: 573 LDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTA 631
>gi|2506118|sp|P08183|MDR1_HUMAN Multidrug resistance protein 1
(P-glycoprotein 1) (CD243 antigen)
gi|1070659|pir||DVHU1 multidrug resistance protein 1 - human
gi|386862|gb|AAA59576.1| P glycoprotein
Length = 1280
Score = 672 bits (1734), Expect = 0.0
Identities = 374/889 (42%), Positives = 547/889 (61%), Gaps = 11/889 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
E+KILKG++ +V G+TVALVG+SGCGKST++ L+ R Y+ GM+ +DG I+ N+R+
Sbjct: 406 EVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRF 465
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR IG+V QEP++F T+AENIR G +T +IE+A K ANA++FI KL ++DT++G
Sbjct: 466 LREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVG 525
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA +GRTT+ I
Sbjct: 526 ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVI 585
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ------EIERAXXXX 703
AHRLST+RNA I FD G+I E+G HDEL+ K+ GIY +V Q E+E A
Sbjct: 586 AHRLSTVRNADVIAGFDDGVIVEKGNHDELM-KEKGIYFKLVTMQTAGNEVELENAAD-- 642
Query: 704 XXXXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXX 883
+S + + E+ + +R S ++S +
Sbjct: 643 ----------------ESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKE 686
Query: 884 XXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV 1063
S + I K E ++ + +I G PAF+I++ ++ + + D
Sbjct: 687 ALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPE 746
Query: 1064 SIKALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDD 1237
+ + N SL F+ L I+ + G GKAGE ++ RLR VFR++++QD S+FDD
Sbjct: 747 TKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDD 806
Query: 1238 SRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXX 1417
++ G+LT+RLA DA V+ AI RLA + I +L G+ ++F YGW + +
Sbjct: 807 PKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVP 866
Query: 1418 XXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKS 1597
L + +D A ++ TE+I N++TV +LT+++ + + +
Sbjct: 867 IIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQV 926
Query: 1598 PHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASM 1777
P+R ++ + ++F+ + + +++A + FG +L+++ + V V A+ +M
Sbjct: 927 PYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAM 986
Query: 1778 SVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYPN 1954
+V +S+ P+Y +A+ISA + +I + +ID+ G P T++GN+ V F YP
Sbjct: 987 AVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPT 1046
Query: 1955 RRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSV 2134
R VL G ++ GQT+ALVG SGCGKST +QL+ER+YD L G V +D +I+ L+V
Sbjct: 1047 RPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNV 1106
Query: 2135 KHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYD 2308
+ LR ++ +V QEP LF+ +I ENI YG + ++Q+++ +AA ANIH F+ LP+ Y
Sbjct: 1107 QWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYS 1166
Query: 2309 TSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRT 2488
T VG G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GRT
Sbjct: 1167 TKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRT 1226
Query: 2489 CVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
C+VIAHRLSTIQNAD I+V +NG+ E GTHQ LLA++G+Y+ +V Q+
Sbjct: 1227 CIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1275
Score = 348 bits (893), Expect = 4e-94
Identities = 210/599 (35%), Positives = 330/599 (55%), Gaps = 23/599 (3%)
Frame = +2
Query: 911 SLFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGD------DVSI 1069
S+F +F+Y++ + +++ + +I G P +V+G++ I + G+ +++
Sbjct: 35 SVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITN 94
Query: 1070 KALLNSLWFIL----------LAFTG-GISTLISGSLLGKAGETMSGR----LRMDVFRN 1204
++ +N F + ++G G L++ + +GR +R F
Sbjct: 95 RSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHA 154
Query: 1205 IMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGW 1384
IM+Q+ +FD H+VG L +RL D + I ++ + + F G V F GW
Sbjct: 155 IMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGW 212
Query: 1385 NMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEY 1564
+ + L +++ + +A + E ++ +TV A Q+
Sbjct: 213 KLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKK 272
Query: 1565 MYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVF 1744
+ + + R I + + ++S A + ++A+A+ +G L+ + + V
Sbjct: 273 ELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVL 332
Query: 1745 QVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNI 1921
V ++ + + SV A+ + AR +A +F +I K ID+ +G P IKGN+
Sbjct: 333 TVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNL 392
Query: 1922 NMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVK 2101
R V+F+YP+R+ +L G N+ GQTVALVG SGCGKSTT+QL++R YD G V
Sbjct: 393 EFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVS 452
Query: 2102 IDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTF 2281
+D DIR ++V+ LR+ I +V QEP LF TI ENI YG EN+T D++EKA AN + F
Sbjct: 453 VDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDF 512
Query: 2282 VMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEA 2461
+M LP +DT VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +VQ A
Sbjct: 513 IMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVA 572
Query: 2462 LDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
LDKAR GRT +VIAHRLST++NAD I +G +E+G H L+ +G+Y++LV Q++
Sbjct: 573 LDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTA 631
>gi|2353264|gb|AAB69423.1| P-glycoprotein [Homo sapiens]
Length = 1279
Score = 672 bits (1734), Expect = 0.0
Identities = 374/889 (42%), Positives = 547/889 (61%), Gaps = 11/889 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
E+KILKG++ +V G+TVALVG+SGCGKST++ L+ R Y+ GM+ +DG I+ N+R+
Sbjct: 405 EVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRF 464
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR IG+V QEP++F T+AENIR G +T +IE+A K ANA++FI KL ++DT++G
Sbjct: 465 LREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVG 524
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA +GRTT+ I
Sbjct: 525 ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVI 584
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ------EIERAXXXX 703
AHRLST+RNA I FD G+I E+G HDEL+ K+ GIY +V Q E+E A
Sbjct: 585 AHRLSTVRNADVIAGFDDGVIVEKGNHDELM-KEKGIYFKLVTMQTAGNEVELENAAD-- 641
Query: 704 XXXXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXX 883
+S + + E+ + +R S ++S +
Sbjct: 642 ----------------ESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKE 685
Query: 884 XXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV 1063
S + I K E ++ + +I G PAF+I++ ++ + + D
Sbjct: 686 ALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPE 745
Query: 1064 SIKALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDD 1237
+ + N SL F+ L I+ + G GKAGE ++ RLR VFR++++QD S+FDD
Sbjct: 746 TKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDD 805
Query: 1238 SRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXX 1417
++ G+LT+RLA DA V+ AI RLA + I +L G+ ++F YGW + +
Sbjct: 806 PKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVP 865
Query: 1418 XXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKS 1597
L + +D A ++ TE+I N++TV +LT+++ + + +
Sbjct: 866 IIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQV 925
Query: 1598 PHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASM 1777
P+R ++ + ++F+ + + +++A + FG +L+++ + V V A+ +M
Sbjct: 926 PYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAM 985
Query: 1778 SVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYPN 1954
+V +S+ P+Y +A+ISA + +I + +ID+ G P T++GN+ V F YP
Sbjct: 986 AVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPT 1045
Query: 1955 RRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSV 2134
R VL G ++ GQT+ALVG SGCGKST +QL+ER+YD L G V +D +I+ L+V
Sbjct: 1046 RPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNV 1105
Query: 2135 KHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYD 2308
+ LR ++ +V QEP LF+ +I ENI YG + ++Q+++ +AA ANIH F+ LP+ Y
Sbjct: 1106 QWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYS 1165
Query: 2309 TSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRT 2488
T VG G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GRT
Sbjct: 1166 TKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRT 1225
Query: 2489 CVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
C+VIAHRLSTIQNAD I+V +NG+ E GTHQ LLA++G+Y+ +V Q+
Sbjct: 1226 CIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1274
Score = 348 bits (893), Expect = 4e-94
Identities = 212/601 (35%), Positives = 332/601 (54%), Gaps = 25/601 (4%)
Frame = +2
Query: 911 SLFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGD------DVSI 1069
S+F +F+Y++ + +++ + +I G P +V+G++ I + G+ +++
Sbjct: 35 SVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITN 94
Query: 1070 KALLNSLWFIL----------LAFTG-GISTLISGSLLGKAGETMSGR----LRMDVFRN 1204
++ +N F + ++G G L++ + +GR +R F
Sbjct: 95 RSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHA 154
Query: 1205 IMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGW 1384
IM+Q+ +FD H+VG L +RL D + I ++ + + F G V F GW
Sbjct: 155 IMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGW 212
Query: 1385 NMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEY 1564
+ + L +++ + +A + E ++ +TV A Q+
Sbjct: 213 KLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKK 272
Query: 1565 MYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVF 1744
+ + + R I + + ++S A + ++A+A+ +G L+ S Y++
Sbjct: 273 ELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVL---SGEYSIG 329
Query: 1745 QVIEALNM--ASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKG 1915
QV+ ++ + SV A+ + AR +A +F +I K ID+ +G P IKG
Sbjct: 330 QVLTVFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKG 389
Query: 1916 NINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGS 2095
N+ R V+F+YP+R+ +L G N+ GQTVALVG SGCGKSTT+QL++R YD G
Sbjct: 390 NLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGM 449
Query: 2096 VKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIH 2275
V +D DIR ++V+ LR+ I +V QEP LF TI ENI YG EN+T D++EKA AN +
Sbjct: 450 VSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAY 509
Query: 2276 TFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQ 2455
F+M LP +DT VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +VQ
Sbjct: 510 DFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQ 569
Query: 2456 EALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
ALDKAR GRT +VIAHRLST++NAD I +G +E+G H L+ +G+Y++LV Q+
Sbjct: 570 VALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQT 629
Query: 2636 S 2638
+
Sbjct: 630 A 630
>gi|2852441|gb|AAC02113.1| multidrug resistance p-glycoprotein [Canis
familiaris]
Length = 1280
Score = 672 bits (1733), Expect = 0.0
Identities = 375/889 (42%), Positives = 547/889 (61%), Gaps = 11/889 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
E+KILKG++ +V G+TVALVG+SGCGKST++ L+ R Y+ GM+ +DG I+ N+R
Sbjct: 407 EVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTDGMVCIDGQDIRTINVRH 466
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR G+V QEP++F T+AENIR G +T +IE+A K ANA++FI KL +++DT++G
Sbjct: 467 LREITGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPNKFDTLVG 526
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
+LSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA +GRTT+ I
Sbjct: 527 ERGARLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVI 586
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ------EIERAXXXX 703
AHRLST+RNA I FD G+I E+G HDEL+ K+ GIY +V Q E+E A
Sbjct: 587 AHRLSTVRNADVIAGFDDGVIVEKGNHDELM-KEKGIYFKLVTMQTRGNEIELENATG-- 643
Query: 704 XXXXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXX 883
+S + + E+ + S R+S +
Sbjct: 644 ----------------ESKSESDALEMSPKDSGSSLIKRRSTRRSIHAPQGQDRKLGTKE 687
Query: 884 XXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV 1063
S + I K S E ++ + +I G PAFSI++ ++ I + D
Sbjct: 688 DLNENVPSVSFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSIIFSRIIGIFTRDEDPE 747
Query: 1064 SIKALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDD 1237
+ + N S+ F++L I+ + G GKAGE ++ RLR VFR++++QD S+FDD
Sbjct: 748 TKRQNSNMFSVLFLVLGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDD 807
Query: 1238 SRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXX 1417
++ G+LT+RLA DA V+ AI RLA + I +L G+ ++ YGW + +
Sbjct: 808 PKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVP 867
Query: 1418 XXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKS 1597
L + +D A ++ TE+I N++TV +LT+++ + + +
Sbjct: 868 IIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTREQKFEYMYAQSLQV 927
Query: 1598 PHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASM 1777
P+R ++ + +SF++ + + +++A + FG +L++N + V V A+ +M
Sbjct: 928 PYRNSLRKAHIFGVSFSITQAMMYFSYAGCFRFGAYLVANEFMNFQDVLLVFSAIVFGAM 987
Query: 1778 SVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYPN 1954
+V +S+ P+Y +A++SA + +I + +ID+ G P T++GN+ V F YP
Sbjct: 988 AVGQVSSFAPDYAKAKVSAAHVIMIIEKSPLIDSYSPHGLKPNTLEGNVTFNEVVFNYPT 1047
Query: 1955 RRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSV 2134
R VL G ++ GQT+ALVG SGCGKST +QL+ER+YD L GSV ID +I+ L+V
Sbjct: 1048 RPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGSVLIDGKEIKHLNV 1107
Query: 2135 KHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYD 2308
+ LR ++ +V QEP LF+ +I ENI YG + ++ +++ +AA ANIH F+ LP+ Y+
Sbjct: 1108 QWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIMQAAKEANIHHFIETLPEKYN 1167
Query: 2309 TSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRT 2488
T VG G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GRT
Sbjct: 1168 TRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRT 1227
Query: 2489 CVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
C+VIAHRLSTIQNAD I+V +NGK E GTHQ LLA++G+Y+ ++ Q+
Sbjct: 1228 CIVIAHRLSTIQNADLIVVFQNGKVKEHGTHQQLLAQKGIYFSMISVQA 1276
Score = 345 bits (885), Expect = 3e-93
Identities = 194/487 (39%), Positives = 284/487 (57%), Gaps = 1/487 (0%)
Frame = +2
Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
++R F IM+Q+ +FD H+VG L +RL D + I ++ I + F G
Sbjct: 147 KIRKQFFHAIMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKVGMFFQSIATFFTG 204
Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
V F GW + + L +++ + +A + E ++ +T
Sbjct: 205 FIVGFTPGWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAYAKAGAVAEEVLAAIRT 264
Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
V A Q+ + + + R I + + ++S A + ++A+A+ +G L+ +
Sbjct: 265 VIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTSLVLS 324
Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
+ T V V ++ + + S+ A+ + AR +A +F +I K ID+ +G
Sbjct: 325 SEYTIGQVLTVFFSVLIGAFSIGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGH 384
Query: 1898 TP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
P IKGN+ + V+F+YP+R+ +L G N+ GQTVALVG SGCGKSTT+QL++R
Sbjct: 385 KPDNIKGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRL 444
Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
YD G V ID DIR ++V+HLR+ +V QEP LF TI ENI YG EN+T D++EKA
Sbjct: 445 YDPTDGMVCIDGQDIRTINVRHLREITGVVSQEPVLFATTIAENIRYGRENVTMDEIEKA 504
Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
AN + F+M LP+ +DT VG G RLSGGQKQR+AIARA+VR+PKILLLDEATSALDT
Sbjct: 505 VKEANAYDFIMKLPNKFDTLVGERGARLSGGQKQRIAIARALVRNPKILLLDEATSALDT 564
Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
ESE +VQ ALDKAR GRT +VIAHRLST++NAD I +G +E+G H L+ +G+Y+
Sbjct: 565 ESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYF 624
Query: 2615 RLVEKQS 2635
+LV Q+
Sbjct: 625 KLVTMQT 631
>gi|72475|pir||DVMS1A multidrug resistance protein 1a - mouse
(fragment)
gi|200330|gb|AAA03243.1| mdr1a protein
Length = 1104
Score = 671 bits (1732), Expect = 0.0
Identities = 377/890 (42%), Positives = 547/890 (61%), Gaps = 12/890 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
E++ILKG++ +V G+TVALVG+SGCGKST++ L+ R Y+ GM+ +DG I+ N+R+
Sbjct: 230 EVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRY 289
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR IG+V QEP++F T+AENIR G +T +IE+A K ANA++FI KL ++DT++G
Sbjct: 290 LREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVG 349
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
+SGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA EGRTT+ I
Sbjct: 350 ERGAHVSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVI 409
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ----EIERAXXXXXX 709
AHRLST+RNA I FD G+I E+G HDEL+ ++ GIY +V Q EIE
Sbjct: 410 AHRLSTVRNADVIAGFDGGVIVEQGNHDELM-REKGIYFKLVMTQTAGNEIELGNEACKS 468
Query: 710 XXXXXXXXHRSFHRDSVTS-DEERELQQSLA--RDSTRLRQSMISTTTQVPXXXXXXXXX 880
S +DS +S R ++S+ D R + + VP
Sbjct: 469 KDEIDNLDMSS--KDSGSSLIRRRSTRKSICGPHDQDRKLSTKEALDEDVP--------- 517
Query: 881 XXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDD 1060
AS + I K S E ++ + +I G PAFS+++ ++ + + GG
Sbjct: 518 --------PASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPP 569
Query: 1061 VSIKALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFD 1234
+ + N SL F++L I+ + G GKAGE ++ RLR VF+++++QD S+FD
Sbjct: 570 ETQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFD 629
Query: 1235 DSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXX 1414
D ++ G+LT+RLA DA V+ A RLA + I +L G+ ++ YGW + +
Sbjct: 630 DPKNTTGALTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIV 689
Query: 1415 XXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASK 1594
L + +D + ++ TE+I N++TV +LT+++ + + +
Sbjct: 690 PIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQ 749
Query: 1595 SPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMAS 1774
P+R A+ + ++F+ + + +++A + FG +L++ T V V A+ +
Sbjct: 750 IPYRNAMKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVTQQLMTFENVLLVFSAIVFGA 809
Query: 1775 MSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFAYP 1951
M+V +S+ P+Y +A +SA + +I + ID+ G P ++GN+ GV F YP
Sbjct: 810 MAVGQVSSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYP 869
Query: 1952 NRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLS 2131
R VL G ++ GQT+ALVG SGCGKST +QL+ER+YD + GSV +D +I+ L+
Sbjct: 870 TRPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLN 929
Query: 2132 VKHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGY 2305
V+ LR + +V QEP LF+ +I ENI YG + ++ +++ +AA ANIH F+ LPD Y
Sbjct: 930 VQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKY 989
Query: 2306 DTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGR 2485
+T VG G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GR
Sbjct: 990 NTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGR 1049
Query: 2486 TCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
TC+VIAHRLSTIQNAD I+V +NGK E GTHQ LLA++G+Y+ +V Q+
Sbjct: 1050 TCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQA 1099
Score = 315 bits (808), Expect = 3e-84
Identities = 175/454 (38%), Positives = 263/454 (57%), Gaps = 1/454 (0%)
Frame = +2
Query: 1280 DAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLK 1459
D + I ++ + + F G + F GW + + L
Sbjct: 2 DVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILS 61
Query: 1460 FRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSL 1639
+++ + +A + E ++ +TV A Q+ + + + R I + + ++
Sbjct: 62 SFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANI 121
Query: 1640 SFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAASYFPEYVR 1819
S A + ++A+A+ +G L+ + + V V ++ + + SV A+ +
Sbjct: 122 SMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFAN 181
Query: 1820 ARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSA 1996
AR +A +F +I K ID+ +G P I+GN+ + ++F+YP+R+ +L G N+
Sbjct: 182 ARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNLEFKNIHFSYPSRKEVQILKGLNLKV 241
Query: 1997 NFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEP 2176
GQTVALVG SGCGKSTT+QL++R YD L G V ID DIR ++V++LR+ I +V QEP
Sbjct: 242 KSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGVVSQEP 301
Query: 2177 TLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQ 2356
LF TI ENI YG E++T D++EKA AN + F+M LP +DT VG G +SGGQKQ
Sbjct: 302 VLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAHVSGGQKQ 361
Query: 2357 RVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTIQNADK 2536
R+AIARA+VR+PKILLLDEATSALDTESE +VQ ALDKAR GRT +VIAHRLST++NAD
Sbjct: 362 RIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADV 421
Query: 2537 IIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
I G +E+G H L+ +G+Y++LV Q++
Sbjct: 422 IAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTA 455
>gi|6755048|ref|NP_035206.1| ATP-binding cassette, sub-family B
(MDR/TAP), member 1A; P glycoprotein 3; ATP-binding
cassette, sub-family B (MDR/TAP), member 4; multi-drug
resistance 3; P-glycoprotein; multiple drug resistant 1a
[Mus musculus]
gi|387427|gb|AAA39514.1| P-glycoprotein
Length = 1276
Score = 671 bits (1732), Expect = 0.0
Identities = 377/890 (42%), Positives = 547/890 (61%), Gaps = 12/890 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
E++ILKG++ +V G+TVALVG+SGCGKST++ L+ R Y+ GM+ +DG I+ N+R+
Sbjct: 402 EVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRY 461
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR IG+V QEP++F T+AENIR G +T +IE+A K ANA++FI KL ++DT++G
Sbjct: 462 LREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVG 521
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
+SGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA EGRTT+ I
Sbjct: 522 ERGAHVSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVI 581
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ----EIERAXXXXXX 709
AHRLST+RNA I FD G+I E+G HDEL+ ++ GIY +V Q EIE
Sbjct: 582 AHRLSTVRNADVIAGFDGGVIVEQGNHDELM-REKGIYFKLVMTQTAGNEIELGNEACKS 640
Query: 710 XXXXXXXXHRSFHRDSVTS-DEERELQQSLA--RDSTRLRQSMISTTTQVPXXXXXXXXX 880
S +DS +S R ++S+ D R + + VP
Sbjct: 641 KDEIDNLDMSS--KDSGSSLIRRRSTRKSICGPHDQDRKLSTKEALDEDVP--------- 689
Query: 881 XXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDD 1060
AS + I K S E ++ + +I G PAFS+++ ++ + + GG
Sbjct: 690 --------PASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPP 741
Query: 1061 VSIKALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFD 1234
+ + N SL F++L I+ + G GKAGE ++ RLR VF+++++QD S+FD
Sbjct: 742 ETQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFD 801
Query: 1235 DSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXX 1414
D ++ G+LT+RLA DA V+ A RLA + I +L G+ ++ YGW + +
Sbjct: 802 DPKNTTGALTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIV 861
Query: 1415 XXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASK 1594
L + +D + ++ TE+I N++TV +LT+++ + + +
Sbjct: 862 PIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQ 921
Query: 1595 SPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMAS 1774
P+R A+ + ++F+ + + +++A + FG +L++ T V V A+ +
Sbjct: 922 IPYRNAMKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVTQQLMTFENVLLVFSAIVFGA 981
Query: 1775 MSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFAYP 1951
M+V +S+ P+Y +A +SA + +I + ID+ G P ++GN+ GV F YP
Sbjct: 982 MAVGQVSSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYP 1041
Query: 1952 NRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLS 2131
R VL G ++ GQT+ALVG SGCGKST +QL+ER+YD + GSV +D +I+ L+
Sbjct: 1042 TRPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLN 1101
Query: 2132 VKHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGY 2305
V+ LR + +V QEP LF+ +I ENI YG + ++ +++ +AA ANIH F+ LPD Y
Sbjct: 1102 VQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKY 1161
Query: 2306 DTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGR 2485
+T VG G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GR
Sbjct: 1162 NTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGR 1221
Query: 2486 TCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
TC+VIAHRLSTIQNAD I+V +NGK E GTHQ LLA++G+Y+ +V Q+
Sbjct: 1222 TCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQA 1271
Score = 337 bits (864), Expect = 9e-91
Identities = 188/488 (38%), Positives = 282/488 (57%), Gaps = 1/488 (0%)
Frame = +2
Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
++R F IM Q+ +FD H+VG L +RL D + I ++ + + F G
Sbjct: 142 KIRQKFFHAIMNQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGG 199
Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
+ F GW + + L +++ + +A + E ++ +T
Sbjct: 200 FIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELHAYAKAGAVAEEVLAAIRT 259
Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
V A Q+ + + + R I + + ++S A + ++A+A+ +G L+ +
Sbjct: 260 VIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVIS 319
Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
+ V V ++ + + SV A+ + AR +A +F +I K ID+ +G
Sbjct: 320 KEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFKIIDNKPSIDSFSKSGH 379
Query: 1898 TP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
P I+GN+ + ++F+YP+R+ +L G N+ GQTVALVG SGCGKSTT+QL++R
Sbjct: 380 KPDNIQGNLEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRL 439
Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
YD L G V ID DIR ++V++LR+ I +V QEP LF TI ENI YG E++T D++EKA
Sbjct: 440 YDPLDGMVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKA 499
Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
AN + F+M LP +DT VG G +SGGQKQR+AIARA+VR+PKILLLDEATSALDT
Sbjct: 500 VKEANAYDFIMKLPHQFDTLVGERGAHVSGGQKQRIAIARALVRNPKILLLDEATSALDT 559
Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
ESE +VQ ALDKAR GRT +VIAHRLST++NAD I G +E+G H L+ +G+Y+
Sbjct: 560 ESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYF 619
Query: 2615 RLVEKQSS 2638
+LV Q++
Sbjct: 620 KLVMTQTA 627
>gi|266517|sp|P21447|MDR3_MOUSE Multidrug resistance protein 3
(P-glycoprotein 3) (MDR1A)
gi|110720|pir||A34786 multidrug resistance protein 1a - mouse
gi|387429|gb|AAA39517.1| multidrug resistance protein
Length = 1276
Score = 671 bits (1732), Expect = 0.0
Identities = 378/890 (42%), Positives = 546/890 (60%), Gaps = 12/890 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
E++ILKG++ +V G+TVALVG+SGCGKST++ L+ R Y+ GM+ +DG I+ N+R+
Sbjct: 402 EVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRY 461
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR IG+V QEP++F T+AENIR G +T +IE+A K ANA++FI KL ++DT++G
Sbjct: 462 LREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVG 521
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA EGRTT+ I
Sbjct: 522 ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVI 581
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ----EIERAXXXXXX 709
AHRLST+RNA I FD G+I E+G HDEL+ ++ GIY +V Q EIE
Sbjct: 582 AHRLSTVRNADVIAGFDGGVIVEQGNHDELM-REKGIYFKLVMTQTAGNEIELGNEACKS 640
Query: 710 XXXXXXXXHRSFHRDSVTS-DEERELQQSLA--RDSTRLRQSMISTTTQVPXXXXXXXXX 880
S +DS +S R ++S+ D R + + VP
Sbjct: 641 KDEIDNLDMSS--KDSGSSLIRRRSTRKSICGPHDQDRKLSTKEALDEDVP--------- 689
Query: 881 XXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDD 1060
AS + I K S E ++ + +I G PAFS+++ ++ + + GG
Sbjct: 690 --------PASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPP 741
Query: 1061 VSIKALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFD 1234
+ + N SL F++L I+ + G GKAGE ++ RLR VF+++++QD S+FD
Sbjct: 742 ETQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFD 801
Query: 1235 DSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXX 1414
D ++ G+LT+RLA DA V+ A RLA + I +L G+ ++ YGW + +
Sbjct: 802 DPKNTTGALTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIV 861
Query: 1415 XXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASK 1594
L + +D + ++ TE+I N++TV +LT+++ + + +
Sbjct: 862 PIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQ 921
Query: 1595 SPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMAS 1774
P+R A+ + ++F + + +++A + FG +L++ T V V A+ +
Sbjct: 922 IPYRNAMKKAHVFGITFFFTQAMMYFSYAACFRFGAYLVTQQLMTFENVLLVFSAIVFGA 981
Query: 1775 MSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFAYP 1951
M+V +S+ P+Y +A +SA + +I + ID+ G P ++GN+ G F YP
Sbjct: 982 MAVGQVSSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGFVFNYP 1041
Query: 1952 NRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLS 2131
R VL G ++ GQT+ALVG SGCGKST +QL+ER+YD + GSV +D +I+ L+
Sbjct: 1042 TRPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLN 1101
Query: 2132 VKHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGY 2305
V+ LR + +V QEP LF+ +I ENI YG + ++ +++ +AA ANIH F+ LPD Y
Sbjct: 1102 VQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKY 1161
Query: 2306 DTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGR 2485
+T VG G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GR
Sbjct: 1162 NTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGR 1221
Query: 2486 TCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
TC+VIAHRLSTIQNAD I+V +NGK E GTHQ LLA++G+Y+ +V Q+
Sbjct: 1222 TCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQA 1271
Score = 338 bits (868), Expect = 3e-91
Identities = 189/488 (38%), Positives = 283/488 (57%), Gaps = 1/488 (0%)
Frame = +2
Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
++R F IM Q+ +FD H+VG L +RL D + I ++ + + F G
Sbjct: 142 KIRQKFFHAIMNQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGG 199
Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
+ F GW + + L +++ + +A + E ++ +T
Sbjct: 200 FIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELHAYAKAGAVAEEVLAAIRT 259
Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
V A Q+ + + + R I + + ++S A + ++A+A+ +G L+ +
Sbjct: 260 VIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVIS 319
Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
+ V V ++ + + SV A+ + AR +A +F +I K ID+ +G
Sbjct: 320 KEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFKIIDNKPSIDSFSKSGH 379
Query: 1898 TP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
P I+GN+ + ++F+YP+R+ +L G N+ GQTVALVG SGCGKSTT+QL++R
Sbjct: 380 KPDNIQGNLEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRL 439
Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
YD L G V ID DIR ++V++LR+ I +V QEP LF TI ENI YG E++T D++EKA
Sbjct: 440 YDPLDGMVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKA 499
Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
AN + F+M LP +DT VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDT
Sbjct: 500 VKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 559
Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
ESE +VQ ALDKAR GRT +VIAHRLST++NAD I G +E+G H L+ +G+Y+
Sbjct: 560 ESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYF 619
Query: 2615 RLVEKQSS 2638
+LV Q++
Sbjct: 620 KLVMTQTA 627
>gi|126928|sp|P21449|MDR2_CRIGR Multidrug resistance protein 2
(P-glycoprotein 2)
gi|191167|gb|AAA68884.1| p-glycoprotein isoform II
Length = 1276
Score = 671 bits (1731), Expect = 0.0
Identities = 371/885 (41%), Positives = 545/885 (60%), Gaps = 11/885 (1%)
Frame = +2
Query: 5 LKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWL 184
+KILKG++ +V G+TVALVG SGCGKST++ LL R Y+ G++ +DG I+ N+R+L
Sbjct: 406 IKILKGLNLKVQSGQTVALVGKSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIRTINVRYL 465
Query: 185 RSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIGA 364
R IG+V QEP++F T+AENIR G +T +IE+A K ANA++FI KL ++DT++G
Sbjct: 466 REIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGE 525
Query: 365 GAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIA 544
QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA EGRTT+ IA
Sbjct: 526 RGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIA 585
Query: 545 HRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ------EIERAXXXXX 706
HRLST+RNA I FD G+I E+G H+EL+ K+ GIY +V Q E+
Sbjct: 586 HRLSTVRNADVIAGFDGGVIVEQGNHEELM-KEKGIYCRLVMMQTRGNEVELGSEADGSQ 644
Query: 707 XXXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXX 886
F SV R + S +D R + VP
Sbjct: 645 SDTIASELTSEEFKSPSVRKSTCRSICGS--QDQERRVSVKEAQDEDVPL---------- 692
Query: 887 XXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVS 1066
S + I K E +++ ++ +I G P FSIV+ + + + D +
Sbjct: 693 -------VSFWGILKLNITEWPYLVVGVLCAVINGCMQPVFSIVFSGIIGVFTRDDDPKT 745
Query: 1067 IKALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDS 1240
+ N SL+F+++ ++ G GKAGE ++ RLR VF+++++QD S+FDD
Sbjct: 746 KQQNCNLFSLFFLVMGMICFVTYFFQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDH 805
Query: 1241 RHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXX 1420
R++ G+LT+RLA+DA NV+ A+ RLA + + +L G+ ++ YGW + +
Sbjct: 806 RNSTGALTTRLASDAANVKGAMSSRLAGITQNVANLGTGIIISLVYGWQLTLLLVVIAPL 865
Query: 1421 XXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSP 1600
L + +D + ++ TE+I N++TV +LT+++ + + + + P
Sbjct: 866 IILSGMMEMKVLSGQALKDKKELEVSGKIATEAIENFRTVVSLTREQKFENMYAQSLQIP 925
Query: 1601 HRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMS 1780
+R A+ + ++F+ + + +++A + FG +L+++ T V V A+ +++
Sbjct: 926 YRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVAHQIMTFENVMLVFSAVVFGAIA 985
Query: 1781 VMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFAYPNR 1957
A+S+ P+Y +A++SA + ++ + ID+ G P ++GN+ V F YP R
Sbjct: 986 AGNASSFAPDYAKAKVSASHIIRIMEKIPSIDSYSTRGLKPNWLEGNVKFNEVVFNYPTR 1045
Query: 1958 RRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVK 2137
VL G ++ GQT+ALVG SGCGKST +QL+ER+YD + G+V +D +I+ L+V+
Sbjct: 1046 PDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEIKQLNVQ 1105
Query: 2138 HLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYDT 2311
LR ++ +V QEP LF+ +I ENI YG + ++QD++E+AA ANIH F+ LPD Y+T
Sbjct: 1106 WLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNT 1165
Query: 2312 SVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTC 2491
VG G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GRTC
Sbjct: 1166 RVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTC 1225
Query: 2492 VVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVE 2626
+VIAHRLSTIQNAD I+V +NGK E GTHQ LLA++G+Y+ +V+
Sbjct: 1226 IVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVQ 1270
Score = 331 bits (849), Expect = 5e-89
Identities = 188/487 (38%), Positives = 275/487 (55%), Gaps = 1/487 (0%)
Frame = +2
Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
++R F IM Q+ +FD H++G L +RL D + I ++ I +
Sbjct: 145 KIRQKFFHAIMNQEIGWFDV--HDIGELNTRLTDDVSKINDGIGDKIGMFFQSIATFLAA 202
Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
V F GW + + L +++ + +A + E ++ +T
Sbjct: 203 FIVGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRT 262
Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
V A Q + + + I + + ++S +A V ++A+A+ +G L+ +
Sbjct: 263 VIAFGGQNKELERYNKNLEEAKNVGIKKAVTANISIGIAYLLVYASYALAFWYGTSLVLS 322
Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
N + V V ++ + S+ A + AR +A +F +I + ID+ G
Sbjct: 323 NEYSVGQVLTVFFSILFGTFSIGHIAPNIEVFANARGAAYEIFKIIDNEPSIDSFSTQGH 382
Query: 1898 TP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
P ++ GN+ + V+F+YP+R +L G N+ GQTVALVG SGCGKSTT+QL++R
Sbjct: 383 KPDSVMGNLEFKNVHFSYPSRSGIKILKGLNLKVQSGQTVALVGKSGCGKSTTVQLLQRL 442
Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
YD G V ID DIR ++V++LR+ I +V QEP LF TI ENI YG EN+T D++EKA
Sbjct: 443 YDPTEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKA 502
Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
AN + F+M LP +DT VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDT
Sbjct: 503 VKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 562
Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
ESE +VQ ALDKAR GRT +VIAHRLST++NAD I G +E+G H+ L+ +G+Y
Sbjct: 563 ESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIYC 622
Query: 2615 RLVEKQS 2635
RLV Q+
Sbjct: 623 RLVMMQT 629
Score = 251 bits (642), Expect = 5e-65
Identities = 130/226 (57%), Positives = 171/226 (75%), Gaps = 2/226 (0%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
++ +L+G+S EV G+T+ALVG SGCGKST + LL RFY+ AG + LDG I++ N++W
Sbjct: 1047 DIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEIKQLNVQW 1106
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDV--LITDQDIEEACKMANAHEFICKLSDRYDTV 355
LR+ +GIV QEPI+F ++AENI GD +++ +IE A K AN H+FI L D+Y+T
Sbjct: 1107 LRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTR 1166
Query: 356 IGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTL 535
+G QLSGGQKQR+AIARA+VR+P ILLLDEATSALDTESE++VQ ALDKA EGRT +
Sbjct: 1167 VGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCI 1226
Query: 536 CIAHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKA 673
IAHRLSTI+NA I+V G + E GTH +L+++ GIY SMV+A
Sbjct: 1227 VIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQ-KGIYFSMVQA 1271
>gi|42741659|ref|NP_000918.2| ATP-binding cassette sub-family B member
1; multidrug resistance 1; P glycoprotein 1; doxorubicin
resistance; colchicin sensitivity [Homo sapiens]
Length = 1280
Score = 671 bits (1731), Expect = 0.0
Identities = 373/889 (41%), Positives = 547/889 (60%), Gaps = 11/889 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
E+KILKG++ +V G+TVALVG+SGCGKST++ L+ R Y+ GM+ +DG I+ N+R+
Sbjct: 406 EVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRF 465
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR IG+V QEP++F T+AENIR G +T +IE+A K ANA++FI KL ++DT++G
Sbjct: 466 LREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVG 525
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA +GRTT+ I
Sbjct: 526 ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVI 585
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ------EIERAXXXX 703
AHRLST+RNA I FD G+I E+G HDEL+ K+ GIY +V Q E+E A
Sbjct: 586 AHRLSTVRNADVIAGFDDGVIVEKGNHDELM-KEKGIYFKLVTMQTAGNEVELENAAD-- 642
Query: 704 XXXXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXX 883
+S + + E+ + +R S ++S +
Sbjct: 643 ----------------ESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKE 686
Query: 884 XXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV 1063
S + I K E ++ + +I G PAF+I++ ++ + + D
Sbjct: 687 ALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPE 746
Query: 1064 SIKALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDD 1237
+ + N SL F+ L I+ + G GKAGE ++ RLR VFR++++QD S+FDD
Sbjct: 747 TKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDD 806
Query: 1238 SRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXX 1417
++ G+LT+RLA DA V+ AI RLA + I +L G+ ++F YGW + +
Sbjct: 807 PKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVP 866
Query: 1418 XXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKS 1597
L + +D + ++ TE+I N++TV +LT+++ + + +
Sbjct: 867 IIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQV 926
Query: 1598 PHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASM 1777
P+R ++ + ++F+ + + +++A + FG +L+++ + V V A+ +M
Sbjct: 927 PYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAM 986
Query: 1778 SVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYPN 1954
+V +S+ P+Y +A+ISA + +I + +ID+ G P T++GN+ V F YP
Sbjct: 987 AVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPT 1046
Query: 1955 RRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSV 2134
R VL G ++ GQT+ALVG SGCGKST +QL+ER+YD L G V +D +I+ L+V
Sbjct: 1047 RPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNV 1106
Query: 2135 KHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYD 2308
+ LR ++ +V QEP LF+ +I ENI YG + ++Q+++ +AA ANIH F+ LP+ Y
Sbjct: 1107 QWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYS 1166
Query: 2309 TSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRT 2488
T VG G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GRT
Sbjct: 1167 TKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRT 1226
Query: 2489 CVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
C+VIAHRLSTIQNAD I+V +NG+ E GTHQ LLA++G+Y+ +V Q+
Sbjct: 1227 CIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1275
Score = 348 bits (893), Expect = 4e-94
Identities = 210/599 (35%), Positives = 330/599 (55%), Gaps = 23/599 (3%)
Frame = +2
Query: 911 SLFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGD------DVSI 1069
S+F +F+Y++ + +++ + +I G P +V+G++ I + G+ +++
Sbjct: 35 SVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITN 94
Query: 1070 KALLNSLWFIL----------LAFTG-GISTLISGSLLGKAGETMSGR----LRMDVFRN 1204
++ +N F + ++G G L++ + +GR +R F
Sbjct: 95 RSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHA 154
Query: 1205 IMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGW 1384
IM+Q+ +FD H+VG L +RL D + I ++ + + F G V F GW
Sbjct: 155 IMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGW 212
Query: 1385 NMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEY 1564
+ + L +++ + +A + E ++ +TV A Q+
Sbjct: 213 KLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKK 272
Query: 1565 MYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVF 1744
+ + + R I + + ++S A + ++A+A+ +G L+ + + V
Sbjct: 273 ELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVL 332
Query: 1745 QVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNI 1921
V ++ + + SV A+ + AR +A +F +I K ID+ +G P IKGN+
Sbjct: 333 TVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNL 392
Query: 1922 NMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVK 2101
R V+F+YP+R+ +L G N+ GQTVALVG SGCGKSTT+QL++R YD G V
Sbjct: 393 EFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVS 452
Query: 2102 IDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTF 2281
+D DIR ++V+ LR+ I +V QEP LF TI ENI YG EN+T D++EKA AN + F
Sbjct: 453 VDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDF 512
Query: 2282 VMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEA 2461
+M LP +DT VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +VQ A
Sbjct: 513 IMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVA 572
Query: 2462 LDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
LDKAR GRT +VIAHRLST++NAD I +G +E+G H L+ +G+Y++LV Q++
Sbjct: 573 LDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTA 631
>gi|45382457|ref|NP_990225.1| ABC transporter protein [Gallus gallus]
gi|3355757|emb|CAA08835.1| ABC transporter protein; P-glycoprotein
[Gallus gallus]
Length = 1288
Score = 671 bits (1730), Expect = 0.0
Identities = 374/882 (42%), Positives = 530/882 (59%), Gaps = 4/882 (0%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
+++ILKG++ +VN G+TVALVG SGCGKST++ L+ RFY+ G I +DG ++ N+R+
Sbjct: 414 DVEILKGLNLKVNCGQTVALVGGSGCGKSTTVQLIQRFYDPKEGTITIDGQDLKSLNVRY 473
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR IG+V QEP++F T+AENIR G +T ++IE A K ANA++FI KL +++TV+G
Sbjct: 474 LREIIGVVNQEPVLFATTIAENIRYGREDVTMEEIERATKEANAYDFIMKLPKKFETVVG 533
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
Q+SGGQKQR+AIARA+V P+ILLLDEATSALDTESE +VQ ALDKA EGRTT+ +
Sbjct: 534 ERGAQMSGGQKQRIAIARALVHNPKILLLDEATSALDTESESVVQAALDKAREGRTTVVV 593
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
AHRLST+RNA I VF+ G+I E+G H +LI K GIY +V Q IE
Sbjct: 594 AHRLSTVRNADLIAVFESGVITEQGNHSQLIEKK-GIYYKLVNMQTIETEDPSSEKSENA 652
Query: 722 XXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXXXXGA 901
S R S+ + L++ L R STR
Sbjct: 653 V-----SVKRSGSQSNLDESLKKELRRGSTRRSMKKPGEPNDTDEKGSSPDEELP----- 702
Query: 902 MEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV-SIKAL 1078
S + K E + ++ G PAFS+++ ++ I S V K+
Sbjct: 703 -PVSFLKLMKLNKNEWPYFVAGTFCAIVNGALQPAFSVIFSEIIGIFSETDQKVLREKSN 761
Query: 1079 LNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGS 1258
L SL F+ L + + G GKAGE ++ +LR F+ +++QD ++FDD +++ G+
Sbjct: 762 LYSLLFLALGIISFFTFFVQGFAFGKAGEILTMKLRFMAFKAMLRQDMAWFDDPKNSTGA 821
Query: 1259 LTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXX 1438
LT+RLA DA V+ A RLA + I +L G+ ++ YGW + +
Sbjct: 822 LTTRLANDASQVKGATGVRLALIAQNIANLGTGIIISLVYGWQLTLLLLAVVPIIAVAGM 881
Query: 1439 XXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIV 1618
L ++D A ++ TE+I N +TV +LT+++ + P+R ++
Sbjct: 882 IEMKMLAGHAKKDKIELEAAGKIATEAIENIRTVASLTREKRFELMYGEHLLVPYRNSVK 941
Query: 1619 RGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAAS 1798
+ F+L+ + + + +A + FG +L+ N TVF V A+ +M++ +S
Sbjct: 942 KAHIFGFCFSLSQAMMFFTYAGCFRFGAYLVVNGHIEYKTVFLVFSAVVFGAMALGQTSS 1001
Query: 1799 YFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFAYPNRRRQLVL 1975
+ P+Y +A+ISA +F + + ID+ G+ P GN ++ V F YPNR +L
Sbjct: 1002 FAPDYAKAKISAAHLFVLFNRVPPIDSYREDGEKPEKFGGNTRIKDVKFNYPNRPEVKIL 1061
Query: 1976 DGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNI 2155
G N++ G+T+ALVG SGCGKST +QL+ER+YD L G + DD D + L+++ LR +I
Sbjct: 1062 QGLNLAVEKGETLALVGSSGCGKSTVVQLLERFYDPLSGEIVFDDIDAKTLNIQWLRSHI 1121
Query: 2156 ALVGQEPTLFNLTIRENITYG--LENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASG 2329
+V QEP LF+ TI ENI YG ++ +++ AA A+IH+F+ LP+ Y+T VG G
Sbjct: 1122 GIVSQEPILFDFTIAENIAYGDNSREVSHEEIISAAKAASIHSFIDSLPEKYNTRVGDKG 1181
Query: 2330 GRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHR 2509
+LSGGQKQR+AIARA++R P+ILLLDEATSALDTESEKIVQEALDKAR GRTC+VIAHR
Sbjct: 1182 TQLSGGQKQRIAIARALIRKPQILLLDEATSALDTESEKIVQEALDKAREGRTCIVIAHR 1241
Query: 2510 LSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
LSTIQNADKI V +NGK IE+GTHQ LLA +G YY LV QS
Sbjct: 1242 LSTIQNADKIAVIQNGKVIEQGTHQQLLAEKGFYYSLVNVQS 1283
Score = 330 bits (846), Expect = 1e-88
Identities = 187/487 (38%), Positives = 279/487 (56%), Gaps = 1/487 (0%)
Frame = +2
Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
++R F IM+Q+ +FD + + G L +RL D + I ++ ++ + G
Sbjct: 154 KIREKFFHAIMRQEIGWFDVN--DAGELNTRLIDDVSKINEGIGDKIGFLIQSETTFLTG 211
Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
V F GW + + L ++ + +A + E +S +T
Sbjct: 212 FIVGFIRGWKLTLVILAVSPVLGLSAALWAKILTAFTDKEQAAYAKAGAVAEEVLSAVRT 271
Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
V A QE + + R I + + ++S A + ++A+A+ +G LI
Sbjct: 272 VIAFGGQEKEIKRYHKNLEDAKRIGIRKAITSNISMGAAFLLIYASYALAFWYGTTLILA 331
Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
N + V V ++ + + S+ A + AR +A +F +I + ID+ G
Sbjct: 332 NEYSIGNVLTVFFSVLIGAFSIGQTAPSIEAFANARGAAYAIFNIIDNEPEIDSYSDAGH 391
Query: 1898 TPT-IKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
P IKGN+ + V+F YP+R +L G N+ N GQTVALVG SGCGKSTT+QLI+R+
Sbjct: 392 KPDHIKGNLEFQNVFFNYPSRPDVEILKGLNLKVNCGQTVALVGGSGCGKSTTVQLIQRF 451
Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
YD G++ ID D++ L+V++LR+ I +V QEP LF TI ENI YG E++T +++E+A
Sbjct: 452 YDPKEGTITIDGQDLKSLNVRYLREIIGVVNQEPVLFATTIAENIRYGREDVTMEEIERA 511
Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
AN + F+M LP ++T VG G ++SGGQKQR+AIARA+V +PKILLLDEATSALDT
Sbjct: 512 TKEANAYDFIMKLPKKFETVVGERGAQMSGGQKQRIAIARALVHNPKILLLDEATSALDT 571
Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
ESE +VQ ALDKAR GRT VV+AHRLST++NAD I V +G E+G H L+ ++G+YY
Sbjct: 572 ESESVVQAALDKAREGRTTVVVAHRLSTVRNADLIAVFESGVITEQGNHSQLIEKKGIYY 631
Query: 2615 RLVEKQS 2635
+LV Q+
Sbjct: 632 KLVNMQT 638
>gi|31442763|gb|AAN07780.2| multidrug resistance p-glycoprotein
[Macaca fascicularis]
Length = 1283
Score = 671 bits (1730), Expect = 0.0
Identities = 376/890 (42%), Positives = 551/890 (61%), Gaps = 12/890 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
E+KILKG++ +V G+TVALVG+SGCGKST++ L+ R Y+ GM+ +DG I+ N+R+
Sbjct: 409 EVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRF 468
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR IG+V QEP++F T+AENIR G +T +IE+A K ANA++FI KL ++DT++G
Sbjct: 469 LREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPQKFDTLVG 528
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA +GRTT+ I
Sbjct: 529 ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVI 588
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ------EIERAXXXX 703
AHRLST+RNA I FD G+I E+G HDEL+ K+ GIY +V Q E+E A
Sbjct: 589 AHRLSTVRNADVIAGFDDGVIVEKGNHDELM-KEKGIYFKLVTMQTAGNEIELENAADES 647
Query: 704 XXXXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXX 883
S H + +R ++S+ + R+ +ST +
Sbjct: 648 KSEIDTL---EMSSHDSGSSLIRKRSTRRSVRGSQGQDRK--LSTKEALDESIP------ 696
Query: 884 XXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV 1063
S + I K E ++ + +I G PAF++++ ++ I + DD
Sbjct: 697 -------PVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAVIFSKIIGIFTRN-DDA 748
Query: 1064 SIK---ALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFD 1234
K + L SL F++L I+ + G GKAGE ++ RLR VFR++++QD S+FD
Sbjct: 749 ETKRQNSNLFSLLFLVLGIVSFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFD 808
Query: 1235 DSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXX 1414
D ++ G+LT+RLA DA V+ AI RLA + I +L G+ ++ YGW + +
Sbjct: 809 DPKNTTGALTTRLANDAAQVKGAIGSRLAIITQNIANLGTGIIISLIYGWQLTLLLLAIV 868
Query: 1415 XXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASK 1594
L + +D A ++ TE+I N++TV +LT+++ + + +
Sbjct: 869 PIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYDQSLQ 928
Query: 1595 SPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMAS 1774
P+R ++ + ++F+ + + +++A + FG +L++++ + V V A+ +
Sbjct: 929 VPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHSLMSFEDVLLVFSAVVFGA 988
Query: 1775 MSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYP 1951
M+V +S+ P+Y +A++SA + +I + +ID+ G P T++GN+ V F YP
Sbjct: 989 MAVGQVSSFAPDYAKAKVSAAHIIMIIEKTPLIDSYSTEGLKPNTLEGNVTFNEVVFNYP 1048
Query: 1952 NRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLS 2131
R VL G ++ GQT+ALVG SGCGKST +QL+ER+YD L G V +D +I+ L+
Sbjct: 1049 TRLDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKQLN 1108
Query: 2132 VKHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGY 2305
V+ LR ++ +V QEP LF+ +I ENI YG + ++Q+++ +AA ANIH F+ LP+ Y
Sbjct: 1109 VQWLRAHLGIVSQEPILFDCSISENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKY 1168
Query: 2306 DTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGR 2485
T VG G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GR
Sbjct: 1169 STRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGR 1228
Query: 2486 TCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
TC+VIAHRLSTIQNAD I+V +NG+ E GTHQ LLA++G+Y+ +V Q+
Sbjct: 1229 TCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1278
Score = 343 bits (879), Expect = 2e-92
Identities = 209/602 (34%), Positives = 323/602 (52%), Gaps = 26/602 (4%)
Frame = +2
Query: 911 SLFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGG----------- 1054
S+F +F+Y++ + +++ + +I G P +V+G + + G
Sbjct: 35 SVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGDMTDTFANAGNLGDLGALLFN 94
Query: 1055 --------DDVSIKALLNSLWFILLAFTG-GISTLISGSLLGKAGETMSGR----LRMDV 1195
D V + L + ++G G L++ + +GR +R
Sbjct: 95 NTNSSNITDTVPVMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQF 154
Query: 1196 FRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFY 1375
F IM+Q+ +FD H+VG L +RL D + I ++ + + F G V F
Sbjct: 155 FHAIMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFT 212
Query: 1376 YGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTK 1555
GW + + L +++ + +A + E ++ +TV A
Sbjct: 213 RGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGG 272
Query: 1556 QEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPY 1735
Q+ + + + R I + + ++S A + ++A+A+ +G L+ + +
Sbjct: 273 QKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSKEYSIG 332
Query: 1736 TVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIK 1912
V V ++ + + SV A+ + AR +A +F +I K ID+ +G P IK
Sbjct: 333 QVLTVFFSVLIGAFSVGQASPSIEAFANARGAAFEIFKIIDNKPSIDSYSKSGHKPDNIK 392
Query: 1913 GNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCG 2092
GN+ R V+F+YP+R+ +L G N+ GQTVALVG SGCGKSTT+QL++R YD G
Sbjct: 393 GNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEG 452
Query: 2093 SVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANI 2272
V +D DIR ++V+ LR+ I +V QEP LF TI ENI YG E++T D++EKA AN
Sbjct: 453 MVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANA 512
Query: 2273 HTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIV 2452
+ F+M LP +DT VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +V
Sbjct: 513 YDFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVV 572
Query: 2453 QEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
Q ALDKAR GRT +VIAHRLST++NAD I +G +E+G H L+ +G+Y++LV Q
Sbjct: 573 QVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQ 632
Query: 2633 SS 2638
++
Sbjct: 633 TA 634
>gi|46394984|gb|AAS91648.1| multidrug resistance protein;
P-glycoprotein [Macaca mulatta]
Length = 1283
Score = 671 bits (1730), Expect = 0.0
Identities = 376/890 (42%), Positives = 551/890 (61%), Gaps = 12/890 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
E+KILKG++ +V G+TVALVG+SGCGKST++ L+ R Y+ GM+ +DG I+ N+R+
Sbjct: 409 EVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRF 468
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR IG+V QEP++F T+AENIR G +T +IE+A K ANA++FI KL ++DT++G
Sbjct: 469 LREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPQKFDTLVG 528
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA +GRTT+ I
Sbjct: 529 ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVI 588
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ------EIERAXXXX 703
AHRLST+RNA I FD G+I E+G HDEL+ K+ GIY +V Q E+E A
Sbjct: 589 AHRLSTVRNADVIAGFDDGVIVEKGNHDELM-KEKGIYFKLVTMQTAGNEIELENAADES 647
Query: 704 XXXXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXX 883
S H + +R ++S+ + R+ +ST +
Sbjct: 648 KSEIDTL---EMSSHDSGSSLIRKRSTRRSVRGSQGQDRK--LSTKEALDESIP------ 696
Query: 884 XXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV 1063
S + I K E ++ + +I G PAF++++ ++ I + DD
Sbjct: 697 -------PVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAVIFSKIIGIFTRN-DDA 748
Query: 1064 SIK---ALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFD 1234
K + L SL F++L I+ + G GKAGE ++ RLR VFR++++QD S+FD
Sbjct: 749 ETKQQNSNLFSLLFLVLGIVSFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFD 808
Query: 1235 DSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXX 1414
D ++ G+LT+RLA DA V+ AI RLA + I +L G+ ++ YGW + +
Sbjct: 809 DPKNTTGALTTRLANDAAQVKGAIGSRLAIITQNIANLGTGIIISLIYGWQLTLLLLAIV 868
Query: 1415 XXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASK 1594
L + +D A ++ TE+I N++TV +LT+++ + + +
Sbjct: 869 PIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYDQSLQ 928
Query: 1595 SPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMAS 1774
P+R ++ + ++F+ + + +++A + FG +L++++ + V V A+ +
Sbjct: 929 VPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHSLMSFEDVLLVFSAVVFGA 988
Query: 1775 MSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYP 1951
M+V +S+ P+Y +A++SA + +I + +ID+ G P T++GN+ V F YP
Sbjct: 989 MAVGQVSSFAPDYAKAKVSAAHIIMIIEKTPLIDSYSTEGLKPNTLEGNVTFNEVVFNYP 1048
Query: 1952 NRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLS 2131
R VL G ++ GQT+ALVG SGCGKST +QL+ER+YD L G V +D +I+ L+
Sbjct: 1049 TRLDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKQLN 1108
Query: 2132 VKHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGY 2305
V+ LR ++ +V QEP LF+ +I ENI YG + ++Q+++ +AA ANIH F+ LP+ Y
Sbjct: 1109 VQWLRAHLGIVSQEPILFDCSISENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKY 1168
Query: 2306 DTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGR 2485
T VG G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GR
Sbjct: 1169 STRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGR 1228
Query: 2486 TCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
TC+VIAHRLSTIQNAD I+V +NG+ E GTHQ LLA++G+Y+ +V Q+
Sbjct: 1229 TCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1278
Score = 341 bits (874), Expect = 6e-92
Identities = 208/602 (34%), Positives = 323/602 (53%), Gaps = 26/602 (4%)
Frame = +2
Query: 911 SLFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGG----------- 1054
S+F +F+Y++ + +++ + +I G P +V+G + + G
Sbjct: 35 SVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGDMTDTFANAGNLGDLGALLFN 94
Query: 1055 --------DDVSIKALLNSLWFILLAFTG-GISTLISGSLLGKAGETMSGR----LRMDV 1195
D V + L + ++G G L++ + +GR +R
Sbjct: 95 NTNSSNITDTVPVMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQF 154
Query: 1196 FRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFY 1375
F IM+Q+ +FD H+VG L +RL + + I ++ + + F G V F
Sbjct: 155 FHAIMRQEIGWFDV--HDVGELNTRLTDEVSKINEGIGDKIGMFFQSMATFFTGFIVGFT 212
Query: 1376 YGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTK 1555
GW + + L +++ + +A + E ++ +TV A
Sbjct: 213 RGWKLTLVILAISPILGLSAAAWAKILSSFTDKELLAYAKAGVVAEEVLAAIRTVIAFGG 272
Query: 1556 QEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPY 1735
Q+ + + + R I + + ++S A + ++A+A+ +G L+ + +
Sbjct: 273 QKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSKEYSIG 332
Query: 1736 TVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIK 1912
V V ++ + + SV A+ + AR +A +F +I K ID+ +G P IK
Sbjct: 333 QVLTVFFSVLIGAFSVGQASPSIEAFANARGAAFEIFKIIDNKPSIDSYSKSGHKPDNIK 392
Query: 1913 GNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCG 2092
GN+ R V+F+YP+R+ +L G N+ GQTVALVG SGCGKSTT+QL++R YD G
Sbjct: 393 GNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEG 452
Query: 2093 SVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANI 2272
V +D DIR ++V+ LR+ I +V QEP LF TI ENI YG E++T D++EKA AN
Sbjct: 453 MVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANA 512
Query: 2273 HTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIV 2452
+ F+M LP +DT VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +V
Sbjct: 513 YDFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVV 572
Query: 2453 QEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
Q ALDKAR GRT +VIAHRLST++NAD I +G +E+G H L+ +G+Y++LV Q
Sbjct: 573 QVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQ 632
Query: 2633 SS 2638
++
Sbjct: 633 TA 634
>gi|22775296|gb|AAN07779.1| multidrug resistance p-glycoprotein
[Macaca mulatta]
Length = 1283
Score = 671 bits (1730), Expect = 0.0
Identities = 376/890 (42%), Positives = 551/890 (61%), Gaps = 12/890 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
E+KILKG++ +V G+TVALVG+SGCGKST++ L+ R Y+ GM+ +DG I+ N+R+
Sbjct: 409 EVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRF 468
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR IG+V QEP++F T+AENIR G +T +IE+A K ANA++FI KL ++DT++G
Sbjct: 469 LREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPQKFDTLVG 528
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA +GRTT+ I
Sbjct: 529 ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVI 588
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ------EIERAXXXX 703
AHRLST+RNA I FD G+I E+G HDEL+ K+ GIY +V Q E+E A
Sbjct: 589 AHRLSTVRNADVIAGFDDGVIVEKGNHDELM-KEKGIYFKLVTMQTAGNEIELENAADES 647
Query: 704 XXXXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXX 883
S H + +R ++S+ + R+ +ST +
Sbjct: 648 KSEIDTL---EMSSHDSGSSLIRKRSTRRSVRGSQGQDRK--LSTKEALDESIP------ 696
Query: 884 XXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV 1063
S + I K E ++ + +I G PAF++++ ++ I + DD
Sbjct: 697 -------PVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAVIFSKIIGIFTRN-DDA 748
Query: 1064 SIK---ALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFD 1234
K + L SL F++L I+ + G GKAGE ++ RLR VFR++++QD S+FD
Sbjct: 749 ETKRQNSNLFSLLFLVLGIVSFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFD 808
Query: 1235 DSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXX 1414
D ++ G+LT+RLA DA V+ AI RLA + I +L G+ ++ YGW + +
Sbjct: 809 DPKNTTGALTTRLANDAAQVKGAIGSRLAIITQNIANLGTGIIISLIYGWQLTLLLLAIV 868
Query: 1415 XXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASK 1594
L + +D A ++ TE+I N++TV +LT+++ + + +
Sbjct: 869 PIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYDQSLQ 928
Query: 1595 SPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMAS 1774
P+R ++ + ++F+ + + +++A + FG +L++++ + V V A+ +
Sbjct: 929 VPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHSLMSFEDVLLVFSAVVFGA 988
Query: 1775 MSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYP 1951
M+V +S+ P+Y +A++SA + +I + +ID+ G P T++GN+ V F YP
Sbjct: 989 MAVGQVSSFAPDYAKAKVSAAHIIMIIEKTPLIDSYSTEGLKPNTLEGNVTFNEVVFNYP 1048
Query: 1952 NRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLS 2131
R VL G ++ GQT+ALVG SGCGKST +QL+ER+YD L G V +D +I+ L+
Sbjct: 1049 TRLDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKQLN 1108
Query: 2132 VKHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGY 2305
V+ LR ++ +V QEP LF+ +I ENI YG + ++Q+++ +AA ANIH F+ LP+ Y
Sbjct: 1109 VQWLRAHLGIVSQEPILFDCSISENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKY 1168
Query: 2306 DTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGR 2485
T VG G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GR
Sbjct: 1169 STRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGR 1228
Query: 2486 TCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
TC+VIAHRLSTIQNAD I+V +NG+ E GTHQ LLA++G+Y+ +V Q+
Sbjct: 1229 TCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1278
Score = 344 bits (883), Expect = 5e-93
Identities = 209/602 (34%), Positives = 324/602 (53%), Gaps = 26/602 (4%)
Frame = +2
Query: 911 SLFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGG----------- 1054
S+F +F+Y++ + +++ ++ +I G P +V+G + + G
Sbjct: 35 SVFSMFRYSNWLDKLYMVVGILAAIIHGAGLPLMMLVFGDMTDTFANAGNLGDLGALLFN 94
Query: 1055 --------DDVSIKALLNSLWFILLAFTG-GISTLISGSLLGKAGETMSGR----LRMDV 1195
D V + L + ++G G L++ + +GR +R
Sbjct: 95 NTNSSNITDTVPVMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQF 154
Query: 1196 FRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFY 1375
F IM+Q+ +FD H+VG L +RL D + I ++ + + F G V F
Sbjct: 155 FHAIMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFT 212
Query: 1376 YGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTK 1555
GW + + L +++ + +A + E ++ +TV A
Sbjct: 213 RGWKLTLVILAISPVLGVSAAAWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGG 272
Query: 1556 QEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPY 1735
Q+ + + + R I + + ++S A + ++A+A+ +G L+ + +
Sbjct: 273 QKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSKEYSIG 332
Query: 1736 TVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIK 1912
V V ++ + + SV A+ + AR +A +F +I K ID+ +G P IK
Sbjct: 333 QVLTVFFSVLIGAFSVGQASPSIEAFANARGAAFEIFKIIDNKPSIDSYSKSGHKPDNIK 392
Query: 1913 GNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCG 2092
GN+ R V+F+YP+R+ +L G N+ GQTVALVG SGCGKSTT+QL++R YD G
Sbjct: 393 GNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEG 452
Query: 2093 SVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANI 2272
V +D DIR ++V+ LR+ I +V QEP LF TI ENI YG E++T D++EKA AN
Sbjct: 453 MVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANA 512
Query: 2273 HTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIV 2452
+ F+M LP +DT VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +V
Sbjct: 513 YDFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVV 572
Query: 2453 QEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
Q ALDKAR GRT +VIAHRLST++NAD I +G +E+G H L+ +G+Y++LV Q
Sbjct: 573 QVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQ 632
Query: 2633 SS 2638
++
Sbjct: 633 TA 634
>gi|25297453|pir||D87789 protein C34G6.4 [imported] - Caenorhabditis
elegans
Length = 1289
Score = 670 bits (1729), Expect = 0.0
Identities = 368/886 (41%), Positives = 529/886 (59%), Gaps = 9/886 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
++ +LKG+S E+ G+ +ALVG SGCGKST + LL RFY+ G + +DG+ ++E N+
Sbjct: 406 DIHVLKGISLELKAGDKIALVGSSGCGKSTIVNLLQRFYDPTKGRVLIDGVDLREVNVHS 465
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR IGIV QEP++F T+ ENI+MG+ T + EACKMANA++FI +L D Y T +G
Sbjct: 466 LREQIGIVSQEPVLFDGTIYENIKMGNEHATHDQVVEACKMANANDFIKRLPDGYGTRVG 525
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
VQLSGGQKQR+AIARA+V+ P+ILLLDEATSALDTE+ER VQ ALD+A GRTT+ +
Sbjct: 526 EKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQGALDQAQAGRTTIIV 585
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEI--ERAXXXXXXXX 715
AHRLSTIRN +I VF G I E G+H+EL+SK GI+ M +AQ + ++
Sbjct: 586 AHRLSTIRNVDRIFVFKAGNIVESGSHEELMSKQ-GIFYDMTQAQVVRQQQQEAGKDIED 644
Query: 716 XXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSM-----ISTTTQVPXXXXXXXXX 880
H R S T S+A +L + + + T
Sbjct: 645 TISESAHSHLSRKSSTRSAI-----SIATSIHQLAEEVELIDPFNGQTNQDVIRSRILSA 699
Query: 881 XXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDD 1060
A S+F IFK+ ++ I + I G P F++VY ++F + S D
Sbjct: 700 FGGECKAPPTSMFKIFKFNGDKVGWFIGGIFGAFIFGSVTPVFALVYAEIFNVYSLPADQ 759
Query: 1061 VSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDS 1240
+ F+L+ T + S + LG+ GE+++ +LR + F+N+++QD +++DD
Sbjct: 760 MQANVYFWCGMFVLMGITFFVGFFTSANCLGRCGESLTMKLRFEAFKNLLRQDIAFYDDL 819
Query: 1241 RHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXX 1420
RH G L +R ATDAPNV+ RL VL IV++ +G+ FYYGW +A I
Sbjct: 820 RHGTGKLCTRFATDAPNVRYVFT-RLPVVLASIVTICGALGIGFYYGWQLALI-LVVMVP 877
Query: 1421 XXXXXXXXXXYLKFRGQ-RDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKS 1597
++F Q RD EA ++ ++++ + +TV +L +QE + + +
Sbjct: 878 LLVMGGYFEMQMRFGKQIRDTQLLEEAGKVASQAVEHIRTVHSLNRQEQFHFTYCEYLRE 937
Query: 1598 PHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASM 1777
P + FA + S + + +A A+ G ++ P V++V A++
Sbjct: 938 PFNTNLKHAHTYGAVFAFSQSLIFFMYAAAFYLGSIFVNQQAMQPIDVYRVFFAISFCGQ 997
Query: 1778 SVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNR 1957
+ S+ P+ V+AR++A ++F +I + ID+ +G I GNI++R V+F YP R
Sbjct: 998 MIGNTTSFIPDVVKARLAASLLFYLIEHPTPIDSLSDSGIVKPITGNISIRNVFFNYPTR 1057
Query: 1958 RRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVK 2137
+ VL GF + G+TVALVG SGCGKST + L+ER+Y+ G + ID +IR+L++
Sbjct: 1058 KDTKVLQGFTLDIKAGKTVALVGHSGCGKSTIMGLLERFYNQDKGMIMIDGDNIRNLNIS 1117
Query: 2138 HLRDNIALVGQEPTLFNLTIRENITYGLE-NITQDQVEKAATLANIHTFVMGLPDGYDTS 2314
LR+ + +V QEPTLF+ TI ENI YG N+T ++ +AA +ANIH F++GLPDGYDT
Sbjct: 1118 SLREQVCIVSQEPTLFDCTIGENICYGTNRNVTYQEIVEAAKMANIHNFILGLPDGYDTH 1177
Query: 2315 VGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCV 2494
VG G +LSGGQKQR+AIARA+VR P +LLLDEATSALDTESEKIVQEALD A+ GRTC+
Sbjct: 1178 VGEKGTQLSGGQKQRIAIARALVRSPSVLLLDEATSALDTESEKIVQEALDAAKQGRTCL 1237
Query: 2495 VIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
VIAHRLSTIQN+D I + GK +E+GTH L+ + +Y + E Q
Sbjct: 1238 VIAHRLSTIQNSDVIAIVSEGKIVEKGTHDELIRKSEIYQKFCETQ 1283
Score = 323 bits (829), Expect = 1e-86
Identities = 198/596 (33%), Positives = 324/596 (54%), Gaps = 24/596 (4%)
Frame = +2
Query: 917 FDIFKYASP-EMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILS--------AGGDDVSI 1069
+ IF Y ++ +I V +I G +P +IV G + + G D+V+
Sbjct: 36 YGIFYYTQGVDLLLLITGTVAAVIHGAGFPLLAIVLGGMTTVFLRAQNSDFVVGVDNVNP 95
Query: 1070 KALL-------NS------LWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIM 1210
+ L+ NS +++++L ++ + + E + +LR + + I+
Sbjct: 96 EGLVPISLDEFNSEVVKYCIYYLVLGVLMFFTSYVQIACFESYAERLVHKLRQNYLKAIL 155
Query: 1211 QQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNM 1390
+Q +FD + G+LT+RL D V+ + + A ++ + G GV F+Y W+M
Sbjct: 156 RQQIQWFD--KQQTGNLTARLTDDLERVREGLGDKFALLVQMFAAFLAGYGVGFFYSWSM 213
Query: 1391 APIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMY 1570
+ + R + + ++ A + E+ S+ +TV +L +
Sbjct: 214 TLVMMGFAPLIVLSGAKMSKSMATRTRVEQETYAVAGAIAEETFSSIRTVHSLNGHKREL 273
Query: 1571 DAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPY-TVFQ 1747
D F A + + IV+ + + + + ++A+A+ +G LI N+ + +F
Sbjct: 274 DRFYNALEVGRQTGIVKYCYMGIGVGFSNLCMYSSYALAFWYGSTLIINDPTFDRGLIFT 333
Query: 1748 VIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD-TPTIKGNIN 1924
V A+ S S+ A + + AR +A + +I ID L G +KG+I+
Sbjct: 334 VFFAVLSGSTSLGGALPHLASFGTARGAASTVLRVINSHPKIDPYSLEGILVDNMKGDIS 393
Query: 1925 MRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKI 2104
+ V+F YP+R+ VL G ++ G +ALVG SGCGKST + L++R+YD G V I
Sbjct: 394 FKDVHFRYPSRKDIHVLKGISLELKAGDKIALVGSSGCGKSTIVNLLQRFYDPTKGRVLI 453
Query: 2105 DDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFV 2284
D D+R+++V LR+ I +V QEP LF+ TI ENI G E+ T DQV +A +AN + F+
Sbjct: 454 DGVDLREVNVHSLREQIGIVSQEPVLFDGTIYENIKMGNEHATHDQVVEACKMANANDFI 513
Query: 2285 MGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEAL 2464
LPDGY T VG G +LSGGQKQR+AIARA+V++PKILLLDEATSALDTE+E+ VQ AL
Sbjct: 514 KRLPDGYGTRVGEKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQGAL 573
Query: 2465 DKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
D+A+ GRT +++AHRLSTI+N D+I V + G +E G+H+ L++++G++Y + + Q
Sbjct: 574 DQAQAGRTTIIVAHRLSTIRNVDRIFVFKAGNIVESGSHEELMSKQGIFYDMTQAQ 629
Score = 246 bits (628), Expect = 2e-63
Identities = 132/228 (57%), Positives = 162/228 (70%), Gaps = 1/228 (0%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
+ K+L+G + ++ G+TVALVGHSGCGKST +GLL RFYNQ GMI +DG I+ NI
Sbjct: 1059 DTKVLQGFTLDIKAGKTVALVGHSGCGKSTIMGLLERFYNQDKGMIMIDGDNIRNLNISS 1118
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMG-DVLITDQDIEEACKMANAHEFICKLSDRYDTVI 358
LR + IV QEP +F T+ ENI G + +T Q+I EA KMAN H FI L D YDT +
Sbjct: 1119 LREQVCIVSQEPTLFDCTIGENICYGTNRNVTYQEIVEAAKMANIHNFILGLPDGYDTHV 1178
Query: 359 GAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLC 538
G QLSGGQKQR+AIARA+VR P +LLLDEATSALDTESE++VQ ALD A +GRT L
Sbjct: 1179 GEKGTQLSGGQKQRIAIARALVRSPSVLLLDEATSALDTESEKIVQEALDAAKQGRTCLV 1238
Query: 539 IAHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEI 682
IAHRLSTI+N+ I + +G I E+GTHDELI K + IY + Q I
Sbjct: 1239 IAHRLSTIQNSDVIAIVSEGKIVEKGTHDELIRKSE-IYQKFCETQRI 1285
>gi|833699|gb|AAA75000.1| multidrug resistance protein
gi|1098061|prf||2115220A P-glycoprotein
Length = 1287
Score = 669 bits (1726), Expect = 0.0
Identities = 369/887 (41%), Positives = 552/887 (61%), Gaps = 10/887 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
++++LKG++ + G+TVALVG SGCGKST++ L+ RFY+ G+I LDG I+ NIR+
Sbjct: 416 DIQVLKGLNLNIPSGKTVALVGSSGCGKSTTVQLIQRFYDPEDGVITLDGQDIRSLNIRY 475
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR IG+V QEPI+F T+A+NIR G +T ++IE A K ANA++FI KL D+ +T++G
Sbjct: 476 LREIIGVVSQEPILFDTTIADNIRYGREDVTKEEIERATKEANAYDFIMKLPDKLETLVG 535
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ+ALDKA EGRTT+ +
Sbjct: 536 ERGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQSALDKAREGRTTIVV 595
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
AHRLSTIRNA+ I FD G+I E+G+H EL+ + G+Y ++V Q +E +
Sbjct: 596 AHRLSTIRNANAIAGFDNGVIVEQGSHKELMERG-GVYFNLVTLQTVETS---------- 644
Query: 722 XXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTT-TQVPXXXXXXXXXXXXXX- 895
+ D T E+++ + + R+S +T ++VP
Sbjct: 645 -----KDTEEDLETHIYEKKIPVTHTHSNLVRRKSSRNTIKSKVPETEDKEVDEEEKKKE 699
Query: 896 -GAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIK 1072
G S F + K PE ++ ++ +I G T PAF+I++ ++ + + + +
Sbjct: 700 EGPPPVSFFKVMKLNKPEWPYFVVGVICAMINGATQPAFAIIFSRIIGVFAGPVSQMRSE 759
Query: 1073 ALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNV 1252
+ + SL F+ L I+ + G GKAGE ++ RLR+ F+++++Q+ +FDDS+++
Sbjct: 760 SSMYSLLFLALGGVSFITFFLQGFTFGKAGEILTMRLRLGSFKSMLRQEIGWFDDSKNST 819
Query: 1253 GSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXX 1432
G+LT+RLATDA VQ A RLA + + +L + ++F YGW + +
Sbjct: 820 GALTTRLATDASQVQGATGTRLALLAQNVANLGTAIIISFIYGWQLTLLILAIVPVIAAA 879
Query: 1433 XXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRA 1612
++D +A ++ T+++ N +TV +LT++ + + + P+R +
Sbjct: 880 GLVEMKMFAGHAKKDKKELEKAGKISTDAVLNIRTVVSLTRERKFEAMYEKSLEGPYRNS 939
Query: 1613 IVRGLWQSLSFALAGSF----VMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMS 1780
I + L++ L+ + + W F++ G +L+ VF V A+ + +M+
Sbjct: 940 IKKAHLHGLTYGLSQAHHVLCLCWVFSV---LGAYLVVEGLMKLDEVFLVSSAIVLGAMA 996
Query: 1781 VMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYPNR 1957
+ +S+ P+Y +A ISA +F+++ + ID+ G+ P GN+ +GV F YP R
Sbjct: 997 LGQTSSFAPDYTKAMISAAHIFSLLERVPQIDSYSDQGEKPKNCSGNVVFKGVNFNYPTR 1056
Query: 1958 RRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVK 2137
VL G ++S G+T+ALVG SGCGKSTT+ L+ER+YD G V +D +R+L+++
Sbjct: 1057 PDITVLQGLDISVKQGETLALVGSSGCGKSTTVSLLERFYDPFEGEVLVDGLSVRNLNIQ 1116
Query: 2138 HLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYDT 2311
+R + +V QEP LF+ +I +NI YG N +TQ+++E AA ANIH+F+ L D Y+T
Sbjct: 1117 WVRAQMGIVSQEPILFDCSIGDNIAYGDNNRKVTQEEIETAAKEANIHSFIESLTDKYNT 1176
Query: 2312 SVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTC 2491
VG G +LSGGQKQR+AIARA++R PKILLLDEATSALDTESEK+VQEALDKAR+GRTC
Sbjct: 1177 RVGDKGTQLSGGQKQRIAIARALIRKPKILLLDEATSALDTESEKVVQEALDKARMGRTC 1236
Query: 2492 VVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
+VIAHRLSTIQNADKI V +NGK +E+GTHQ LL +G+Y+ LV Q
Sbjct: 1237 IVIAHRLSTIQNADKIAVIQNGKVVEQGTHQQLLQLKGVYFSLVTIQ 1283
Score = 330 bits (845), Expect = 1e-88
Identities = 200/595 (33%), Positives = 329/595 (54%), Gaps = 18/595 (3%)
Frame = +2
Query: 905 EASLFDIFKYASPEMRNIII-SLVFTLIRGFTWPAFSIVYGQLF-KILSAGGDDV---SI 1069
+ +F +F+Y+S + +++ + +L G P +V+G++ ++ G D +
Sbjct: 48 KVGVFTMFRYSSTSDKMLMLFGTIASLAHGAALPLMMLVFGEMTDSFVNVGQVDTGNFTW 107
Query: 1070 KALLNS------------LWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQ 1213
++++N+ ++ L F + I S + ++R + F +++
Sbjct: 108 ESMINASRELQGQMTTYAYYYSGLGFGVMLCAYIQISFWTLSAGRQIKKIRSNFFHAVLR 167
Query: 1214 QDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMA 1393
Q+ +FD + + G L +RL D + I ++A +L + +L G + F GW +
Sbjct: 168 QEIGWFDIN--DAGELNTRLTDDVSKINEGIGDKIAMLLQSLTTLVTGFIIGFIKGWKLT 225
Query: 1394 PIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYD 1573
+ L +++ + +A + E +S+ +TV A Q
Sbjct: 226 WVMGAISPIMGLSAAIWAKVLSAFTNKELKAYAKAGAVAEEVLSSIRTVFAFGGQNKEIH 285
Query: 1574 AFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVI 1753
+ + + I + + ++S A + +++A+ +G LI + T +V V
Sbjct: 286 RYEKNLEDAKKIGIKKAITANVSIGFAFLMIYAAYSLAFWYGTTLIIDGGYTIGSVLTVF 345
Query: 1754 EALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMR 1930
A+ + + +V + + AR +A +F +I + ID+ G P IKG+I +
Sbjct: 346 FAVIIGAFAVGQTSPNIEAFANARGAAYTIFNIIDNQPKIDSFSKEGLKPDKIKGDIEFK 405
Query: 1931 GVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDD 2110
V F YP+R+ VL G N++ G+TVALVG SGCGKSTT+QLI+R+YD G + +D
Sbjct: 406 NVIFTYPSRKDIQVLKGLNLNIPSGKTVALVGSSGCGKSTTVQLIQRFYDPEDGVITLDG 465
Query: 2111 SDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMG 2290
DIR L++++LR+ I +V QEP LF+ TI +NI YG E++T++++E+A AN + F+M
Sbjct: 466 QDIRSLNIRYLREIIGVVSQEPILFDTTIADNIRYGREDVTKEEIERATKEANAYDFIMK 525
Query: 2291 LPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDK 2470
LPD +T VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +VQ ALDK
Sbjct: 526 LPDKLETLVGERGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQSALDK 585
Query: 2471 ARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
AR GRT +V+AHRLSTI+NA+ I NG +E+G+H+ L+ R G+Y+ LV Q+
Sbjct: 586 AREGRTTIVVAHRLSTIRNANAIAGFDNGVIVEQGSHKELMERGGVYFNLVTLQT 640
>gi|6755046|ref|NP_035205.1| ATP-binding cassette, sub-family B
(MDR/TAP), member 1B; P glycoprotein 1 [Mus musculus]
gi|126927|sp|P06795|MDR1_MOUSE Multidrug resistance protein 1
(P-glycoprotein 1)
gi|72474|pir||DVMS1 multidrug resistance protein 1 - mouse
gi|387426|gb|AAA79005.1| multidrug resistance protein
Length = 1276
Score = 668 bits (1723), Expect = 0.0
Identities = 369/884 (41%), Positives = 549/884 (61%), Gaps = 9/884 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
E++ILKG++ +V G+TVALVG+SGCGKST++ L+ R Y+ G++ +DG I+ N+R+
Sbjct: 405 EVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLEGVVSIDGQDIRTINVRY 464
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR IG+V QEP++F T+AENIR G +T +IE+A K ANA++FI KL ++DT++G
Sbjct: 465 LREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVG 524
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA EGRTT+ I
Sbjct: 525 ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVI 584
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ----EIERAXXXXXX 709
AHRLST+RNA I FD G+I E+G HDEL+ ++ GIY +V Q EIE
Sbjct: 585 AHRLSTVRNADVIAGFDGGVIVEQGNHDELM-REKGIYFKLVMTQTRGNEIEPG------ 637
Query: 710 XXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXX 889
+ ++ S T E ++S S +R+S+ + +
Sbjct: 638 --------NNAYGSQSDTDASELTSEES---KSPLIRRSIYRSVHRKQDQERRLSMKEAV 686
Query: 890 XXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSI 1069
S + I E +++ ++ +I G P F+IV+ ++ + S D +
Sbjct: 687 DEDVPLVSFWRILNLNLSEWPYLLVGVLCAVINGCIQPVFAIVFSRIVGVFSRDDDHETK 746
Query: 1070 KALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSR 1243
+ N SL+F+++ ++ G GKAGE ++ R+R VF+++++QD S+FDD +
Sbjct: 747 RQNCNLFSLFFLVMGLISFVTYFFQGFTFGKAGEILTKRVRYMVFKSMLRQDISWFDDHK 806
Query: 1244 HNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXX 1423
++ GSLT+RLA+DA +V+ A+ RLA V + +L GV ++ YGW + +
Sbjct: 807 NSTGSLTTRLASDASSVKGAMGARLAVVTQNVANLGTGVILSLVYGWQLTLLLVVIIPLI 866
Query: 1424 XXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPH 1603
L + +D + ++ TE+I N++T+ +LT+++ + + + P+
Sbjct: 867 VLGGIIEMKLLSGQALKDKKQLEISGKIATEAIENFRTIVSLTREQKFETMYAQSLQVPY 926
Query: 1604 RRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSV 1783
R A+ + ++F+ + + +++A + FG +L++ T V V A+ +M+
Sbjct: 927 RNAMKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVAQQLMTFENVMLVFSAVVFGAMAA 986
Query: 1784 MLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFAYPNRR 1960
+S+ P+Y +A++SA + +I + ID+ G PT ++GN+ GV F YP R
Sbjct: 987 GNTSSFAPDYAKAKVSASHIIRIIEKTPEIDSYSTEGLKPTLLEGNVKFNGVQFNYPTRP 1046
Query: 1961 RQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKH 2140
VL G ++ GQT+ALVG SGCGKST +QL+ER+YD + GSV +D +I+ L+V+
Sbjct: 1047 NIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQW 1106
Query: 2141 LRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYDTS 2314
LR ++ +V QEP LF+ +I ENI YG + ++ +++ +AA ANIH F+ LPD Y+T
Sbjct: 1107 LRAHLGIVSQEPILFDCSIAENIAYGDNSRAVSHEEIVRAAKEANIHQFIDSLPDKYNTR 1166
Query: 2315 VGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCV 2494
VG G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GRTC+
Sbjct: 1167 VGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCI 1226
Query: 2495 VIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVE 2626
VIAHRLSTIQNAD I+V NGK E GTHQ LLA++G+Y+ +V+
Sbjct: 1227 VIAHRLSTIQNADLIVVIENGKVKEHGTHQQLLAQKGIYFSMVQ 1270
Score = 338 bits (866), Expect = 5e-91
Identities = 212/597 (35%), Positives = 317/597 (52%), Gaps = 23/597 (3%)
Frame = +2
Query: 914 LFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLF------------KILSAGG 1054
+F +F+YA + +I+ + +I G P +V+G + I + G
Sbjct: 35 VFGMFRYADWLDKLCMILGTLAAIIHGTLLPLLMLVFGNMTDSFTKAEASILPSITNQSG 94
Query: 1055 DD----VSIKALLNSLWFILLAFTG-GISTLISG----SLLGKAGETMSGRLRMDVFRNI 1207
+ +S +L + +TG G LI SL A ++R F I
Sbjct: 95 PNSTLIISNSSLEEEMAIYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAI 154
Query: 1208 MQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWN 1387
M Q+ +FD H+VG L +RL D + I ++ I + G + F GW
Sbjct: 155 MNQEIGWFDV--HDVGELNTRLTDDVSKINDGIGDKIGMFFQSITTFLAGFIIGFISGWK 212
Query: 1388 MAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYM 1567
+ + L +++ + +A + E ++ +TV A Q+
Sbjct: 213 LTLVILAVSPLIGLSSALWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQQKE 272
Query: 1568 YDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQ 1747
+ + + I + + S+S +A V ++A+A+ +G L+ +N + V
Sbjct: 273 LERYNKNLEEAKNVGIKKAITASISIGIAYLLVYASYALAFWYGTSLVLSNEYSIGEVLT 332
Query: 1748 VIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNIN 1924
V ++ + + S+ A + AR +A +F +I + ID+ G P +I GN+
Sbjct: 333 VFFSILLGTFSIGHLAPNIEAFANARGAAFEIFKIIDNEPSIDSFSTKGYKPDSIMGNLE 392
Query: 1925 MRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKI 2104
+ V+F YP+R +L G N+ GQTVALVG SGCGKSTT+QL++R YD L G V I
Sbjct: 393 FKNVHFNYPSRSEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLEGVVSI 452
Query: 2105 DDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFV 2284
D DIR ++V++LR+ I +V QEP LF TI ENI YG E++T D++EKA AN + F+
Sbjct: 453 DGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFI 512
Query: 2285 MGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEAL 2464
M LP +DT VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +VQ AL
Sbjct: 513 MKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAAL 572
Query: 2465 DKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
DKAR GRT +VIAHRLST++NAD I G +E+G H L+ +G+Y++LV Q+
Sbjct: 573 DKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQT 629
>gi|2149087|gb|AAB58489.1| multidrug resistance protein-1 [Ovis aries]
Length = 1285
Score = 667 bits (1722), Expect = 0.0
Identities = 370/887 (41%), Positives = 547/887 (60%), Gaps = 9/887 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
E+KILKG++ +V G+TVALVG+SGCGKST++ L+ R Y+ GM+ +DG I+ N+R+
Sbjct: 411 EVKILKGLNLKVGSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSIDGQDIRTINVRY 470
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR IG+V QEP++F T+AENIR G +T +I++A K ANA++FI KL +++DT++G
Sbjct: 471 LREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIQKAVKEANAYDFIMKLPNKFDTLVG 530
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
QLSGGQKQR+AIARA+VR P+ILLLDEATSAL TESE +VQ ALDKA +GRTT+ I
Sbjct: 531 ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALGTESEAVVQAALDKARKGRTTIVI 590
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMV----KAQEIERAXXXXXX 709
AHRLST+RNA I D G+I E G+HDEL+ K GIY +V K E+E
Sbjct: 591 AHRLSTVRNADIIAGLDDGVIVEEGSHDELMGKR-GIYFKLVTMQTKGNELELENTPG-- 647
Query: 710 XXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXX 889
+S++ ++ + +R S R+S +
Sbjct: 648 --------------ESLSKTDDLYMSSQDSRSSLIRRKSTRRSIRGSQSQDRKLSTEETL 693
Query: 890 XXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSI 1069
S + I K E ++ + +I G PAFS+++ ++ I + +D +
Sbjct: 694 DESVPPVSFWRILKLNITEWPYFVVGVFCAIINGALQPAFSVIFSRIIGIFTRNDNDETK 753
Query: 1070 KALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSR 1243
+ N SL F++L I+ + G GKAGE ++ RLR VFR++++QD S+FDD +
Sbjct: 754 RQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTRRLRYLVFRSMLRQDVSWFDDPK 813
Query: 1244 HNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXX 1423
+ G+LT+RLA DA V+ A+ RLA + I +L G+ ++ YGW + +
Sbjct: 814 NTTGALTTRLANDAAQVKGAVGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPII 873
Query: 1424 XXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPH 1603
L + +D A ++ TE+I N++TV +LT++E + + + P+
Sbjct: 874 AVAGVIEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTREERFEYMYAQSLQVPY 933
Query: 1604 RRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSV 1783
R ++ R ++F++ + + +++A + FG +L++ V V A+ +M+V
Sbjct: 934 RNSLRRAHVFGITFSITQAMMYFSYAGCFRFGAYLVAQGIMEFQDVLLVFSAVVFGAMAV 993
Query: 1784 MLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYPNRR 1960
+++ P+Y +A++SA + +I + +ID+ G P T++G++ V F YP R
Sbjct: 994 GQVSTFAPDYAKAKVSAAHVINIIEKIPLIDSYSTEGLKPSTVEGSVAFNDVVFNYPTRP 1053
Query: 1961 RQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKH 2140
VL G ++ GQT+ALVG SGCGKST +QL+ER+YD L G+V ID +++ L+V+
Sbjct: 1054 DVPVLRGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFIDGKEVKQLNVQW 1113
Query: 2141 LRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYDTS 2314
LR ++ +V QEP LF+ +I ENI YG + ++Q+++E AA ANIH+F+ LPD Y+T
Sbjct: 1114 LRAHMGIVSQEPILFDCSIGENIAYGDNSRVVSQEEIEHAAKEANIHSFIEMLPDKYNTR 1173
Query: 2315 VGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCV 2494
VG G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GRTC+
Sbjct: 1174 VGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCI 1233
Query: 2495 VIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
VIAHRLSTIQNAD I+V +NG+ E GTHQ LLA++G+Y+ +V Q+
Sbjct: 1234 VIAHRLSTIQNADLIVVFQNGRIKEHGTHQQLLAQKGIYFTMVSVQA 1280
Score = 346 bits (887), Expect = 2e-93
Identities = 214/599 (35%), Positives = 322/599 (53%), Gaps = 24/599 (4%)
Frame = +2
Query: 911 SLFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSI------ 1069
S F +F+Y++ + +++ + +I G P +V+G + + G+ +I
Sbjct: 39 STFTMFRYSNWLDRLCMVLGTLAAIIHGAGLPLMMLVFGDMTDSFAGAGNLGNITLSNIS 98
Query: 1070 -----------KALLNSLWFILLAFTG-GISTLISG----SLLGKAGETMSGRLRMDVFR 1201
K L + ++G G LI+ S A R+R F
Sbjct: 99 NTSTIDRTEYGKKLEKEMTTYAYYYSGIGAGVLIAAYIQVSFWCLAAGRQVHRIRKQFFH 158
Query: 1202 NIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYG 1381
IMQQ+ +FD H+VG L +RL D + I ++ + + F G + F G
Sbjct: 159 AIMQQEIGWFDV--HDVGKLNTRLTNDVSKINEGIGDKIGMFFQAMATFFTGFIIGFTTG 216
Query: 1382 WNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQE 1561
WN+ + L + + + +A + E ++ KTV A Q+
Sbjct: 217 WNLTLVILAIIPVLGLSAAIWAKILSSFTDKKLLAYAKAGAVAEEVLAAIKTVIAFGGQK 276
Query: 1562 YMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTV 1741
+ + + R I + + ++S A + ++A+A+ +G L+ + + V
Sbjct: 277 KELERYNKNLEEAKRIGIKKAITANISMGAAFLLIYASYALAFWYGTSLVLSREYSIGQV 336
Query: 1742 FQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGN 1918
V ++ + + S+ A+ + AR +A +F +I K ID+ TG P IKGN
Sbjct: 337 LTVFFSVLIGAFSIGQASPNIEAFANARGAAYEVFKIIDNKPSIDSYSNTGHKPDNIKGN 396
Query: 1919 INMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSV 2098
+ R V+F YP+R +L G N+ GQTVALVG SGCGKSTT+QL++R YD G V
Sbjct: 397 LEFRNVHFHYPSRNEVKILKGLNLKVGSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMV 456
Query: 2099 KIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHT 2278
ID DIR ++V++LR+ I +V QEP LF TI ENI YG E++T D+++KA AN +
Sbjct: 457 SIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIQKAVKEANAYD 516
Query: 2279 FVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQE 2458
F+M LP+ +DT VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSAL TESE +VQ
Sbjct: 517 FIMKLPNKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALGTESEAVVQA 576
Query: 2459 ALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
ALDKAR GRT +VIAHRLST++NAD I +G +EEG+H L+ +RG+Y++LV Q+
Sbjct: 577 ALDKARKGRTTIVIAHRLSTVRNADIIAGLDDGVIVEEGSHDELMGKRGIYFKLVTMQT 635
>gi|39587987|emb|CAE57218.1| Hypothetical protein CBG00078
[Caenorhabditis briggsae]
Length = 1282
Score = 667 bits (1722), Expect = 0.0
Identities = 374/894 (41%), Positives = 536/894 (59%), Gaps = 17/894 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
+ KIL G++ + PG +VALVGHSGCGKSTS+GLL R Y G + +DG ++E NI +
Sbjct: 389 DAKILNGLNLTIEPGTSVALVGHSGCGKSTSVGLLTRLYEPETGNVTIDGTDVRELNIDY 448
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR+ +GIVQQEPI+F T+ N+ +G+ + + E CKMANAH+FI K+ YDT+IG
Sbjct: 449 LRNVVGIVQQEPILFNDTIHNNLLLGNPNAKREKMIEVCKMANAHDFIEKMPKGYDTLIG 508
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
G VQLSGGQKQRVAIAR ++R P++LLLDEATSALD +SE +VQ+AL+ AS+GRTT+ I
Sbjct: 509 DGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALNNASKGRTTIMI 568
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEI-----------ER 688
AHRLSTIR A I+ F++G+I E G H EL+ + +G Y +VKAQ E
Sbjct: 569 AHRLSTIREADMIVFFEKGVIVEAGNHAELV-RLEGRYYDLVKAQAFKPDDNPISQYDEI 627
Query: 689 AXXXXXXXXXXXXXXHRSFHRDSVTS---DEERELQQSLARDSTRLRQSMISTTTQVPXX 859
A +S S+ S E + +L DS +S +
Sbjct: 628 AEDIDLGPSATAIHSRQSSFTSSIRSRISGAEAFRRGTLGADSFAGGRSSARADAE-NAA 686
Query: 860 XXXXXXXXXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFK- 1036
G + A DIFK A +++ V LIRG AF++++G +F+
Sbjct: 687 FAEEVAKVMEQDGQISAGFLDIFKNAHGNYTVMLLGFVTGLIRGLELTAFALLFGWVFEG 746
Query: 1037 --ILSAGGDDVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIM 1210
L+ + + + + + F +S +S E ++ R R+ FRN++
Sbjct: 747 FQYLTVDNGKMMHRMAMAVIAYGCSGFGCFVSQFLSSVFFAIVSENLALRFRVMSFRNLL 806
Query: 1211 QQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNM 1390
QDAS+FD+ H G L +RLATDAPN + +D R+ +VL + ++ + +AF Y W +
Sbjct: 807 YQDASFFDNPAHAPGKLITRLATDAPNCKTVVDSRMLQVLYALSAIIANIAIAFIYCWYL 866
Query: 1391 APIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMY 1570
A +G + + + EA R+ E I N KT+Q LT+ ++ +
Sbjct: 867 AILGTALIILLAVTMCGLAYKISLLNMKQIQDD-EAGRIAIEIIENVKTIQLLTRCDHFF 925
Query: 1571 DAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQV 1750
+ + +SKS R + +GL +++++ + SF+ + + G+ LI + VFQ
Sbjct: 926 ERYQKSSKSQKRSELKKGLIEAVNYTITQSFMYYMMCFCFALGIRLIYQGNKSSQDVFQG 985
Query: 1751 IEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMR 1930
A+ + +M VM +A YFPE+V+A+ ++G++F +I +K + + G P ++GNI
Sbjct: 986 NIAMLLTAMGVMNSAQYFPEFVKAKTASGLLFNIIYRKPRTGDL-MEGTCPEVRGNILFE 1044
Query: 1931 GVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDD 2110
V F+YP R Q ++ G +A GQTVALVGPSG GKST I ++ER+YD G ++ID
Sbjct: 1045 DVKFSYPQRPHQPIMKGLQWTALRGQTVALVGPSGSGKSTCIGMLERFYDVTGGVLRIDG 1104
Query: 2111 SDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMG 2290
DIR LS+ HLR +ALVGQEP LF TI+ENI GLEN++ +++ A LAN + F+
Sbjct: 1105 QDIRGLSLFHLRTQMALVGQEPRLFAGTIKENICLGLENVSMEKINHALELANANRFLSN 1164
Query: 2291 LPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDK 2470
LP G +T VG G +LSGGQKQR+AIARA+VRDPKILLLDEATSALD+ESEK VQEALD+
Sbjct: 1165 LPAGIETDVGEKGSKLSGGQKQRIAIARALVRDPKILLLDEATSALDSESEKAVQEALDR 1224
Query: 2471 ARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
AR GRTC+ IAHRLS+IQN+D I+ NG+ E G H+ L+A++G YY L++KQ
Sbjct: 1225 AREGRTCITIAHRLSSIQNSDVIVYIENGRVQEAGNHKQLMAKKGKYYELIQKQ 1278
Score = 302 bits (773), Expect = 3e-80
Identities = 176/521 (33%), Positives = 281/521 (53%), Gaps = 10/521 (1%)
Frame = +2
Query: 1103 LAFTGGISTLISG-----SLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSLTS 1267
L F G I +ISG + ++R ++++Q+A +FD +++ G++ +
Sbjct: 98 LLFIGIICAIISGISQPYMCFQHCCSRIMAQMRHRYVYSVLRQNAGWFD--KNHSGTIAT 155
Query: 1268 RLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXXXXX 1447
+L ++ I +L ++ G+ L + VA+ Y W +A +
Sbjct: 156 KLNDSMERIREGIGDKLGVLIRGVAMLLASIVVAYIYEWRLACMMLGVAPTCVGCMSLMA 215
Query: 1448 XYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVRGL 1627
+ +++ +A + ES+ +TVQA QE M + + + AI +G
Sbjct: 216 RQMTATTVKELGGVEKAGSIAEESLMGVRTVQAFNGQEEMVERYRVELNKGRKFAIWKGF 275
Query: 1628 WQSLSFALAGSFVMWNFAI---AYMFGLWLISNNWST-PYTVFQVIEALNMASMSVMLAA 1795
W L G F W FA +++G +L+ T P VF ++ A+ + S + L +
Sbjct: 276 WSGL---YGGLFFFWLFAFQGCGFLYGAYLLKIGIITSPGDVFIIVMAMLLGSYFLGLIS 332
Query: 1796 SYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD-TPTIKGNINMRGVYFAYPNRRRQLV 1972
+ + AR++A ++ I + ID G + G + V+F YP R+ +
Sbjct: 333 PHLMVLLNARVAAASIYETIERVPKIDPYSKKGRFLDKVIGRVKFENVHFRYPTRKDAKI 392
Query: 1973 LDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDN 2152
L+G N++ G +VALVG SGCGKST++ L+ R Y+ G+V ID +D+R+L++ +LR+
Sbjct: 393 LNGLNLTIEPGTSVALVGHSGCGKSTSVGLLTRLYEPETGNVTIDGTDVRELNIDYLRNV 452
Query: 2153 IALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGG 2332
+ +V QEP LFN TI N+ G N ++++ + +AN H F+ +P GYDT +G G
Sbjct: 453 VGIVQQEPILFNDTIHNNLLLGNPNAKREKMIEVCKMANAHDFIEKMPKGYDTLIGDGGV 512
Query: 2333 RLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRL 2512
+LSGGQKQRVAIAR ++RDPK+LLLDEATSALD +SE +VQ AL+ A GRT ++IAHRL
Sbjct: 513 QLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALNNASKGRTTIMIAHRL 572
Query: 2513 STIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
STI+ AD I+ G +E G H L+ G YY LV+ Q+
Sbjct: 573 STIREADMIVFFEKGVIVEAGNHAELVRLEGRYYDLVKAQA 613
Score = 201 bits (511), Expect = 7e-50
Identities = 106/224 (47%), Positives = 156/224 (69%)
Frame = +2
Query: 11 ILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWLRS 190
I+KG+ + G+TVALVG SG GKST IG+L RFY+ G++++DG I+ ++ LR+
Sbjct: 1058 IMKGLQWTALRGQTVALVGPSGSGKSTCIGMLERFYDVTGGVLRIDGQDIRGLSLFHLRT 1117
Query: 191 TIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIGAGA 370
+ +V QEP +F T+ ENI +G ++ + I A ++ANA+ F+ L +T +G
Sbjct: 1118 QMALVGQEPRLFAGTIKENICLGLENVSMEKINHALELANANRFLSNLPAGIETDVGEKG 1177
Query: 371 VQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIAHR 550
+LSGGQKQR+AIARA+VR P+ILLLDEATSALD+ESE+ VQ ALD+A EGRT + IAHR
Sbjct: 1178 SKLSGGQKQRIAIARALVRDPKILLLDEATSALDSESEKAVQEALDRAREGRTCITIAHR 1237
Query: 551 LSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEI 682
LS+I+N+ I+ + G + E G H +L++K G Y +++ Q++
Sbjct: 1238 LSSIQNSDVIVYIENGRVQEAGNHKQLMAK-KGKYYELIQKQDL 1280
>gi|1362689|pir||S55692 multidrug resistance protein homolog (mdr) -
African clawed frog
Length = 1287
Score = 666 bits (1718), Expect = 0.0
Identities = 368/887 (41%), Positives = 551/887 (61%), Gaps = 10/887 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
++++LKG++ + G+TVALVG SGCGKST++ L+ RFY+ G+I LDG I+ NIR+
Sbjct: 416 DIQVLKGLNLNIPSGKTVALVGSSGCGKSTTVQLIQRFYDPEDGVITLDGQDIRSLNIRY 475
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR IG+V QEPI+F T+A+NIR G +T ++IE A K ANA++FI KL D+ +T++G
Sbjct: 476 LREIIGVVSQEPILFDTTIADNIRYGREDVTKEEIERATKEANAYDFIMKLPDKLETLVG 535
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ+ALDKA EGRTT+ +
Sbjct: 536 ERGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQSALDKAREGRTTIVV 595
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
AHRLSTIRNA+ I FD G+I E+G+H EL+ + G+Y ++V Q +E +
Sbjct: 596 AHRLSTIRNANAIAGFDNGVIVEQGSHKELMERG-GVYFNLVTLQTVETS---------- 644
Query: 722 XXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTT-TQVPXXXXXXXXXXXXXX- 895
+ D T E+++ + + R+S +T ++VP
Sbjct: 645 -----KDTEEDLETHIYEKKIPVTHTHSNLVRRKSSRNTIKSKVPETEDKEVDEEEKKKE 699
Query: 896 -GAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIK 1072
G S F + K PE ++ ++ +I G T PAF+I++ ++ + + + +
Sbjct: 700 EGPPPVSFFKVMKLNKPEWPYFVVGVICAMINGATQPAFAIIFSRIIGVFAGPVSQMRSE 759
Query: 1073 ALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNV 1252
+ + SL F+ L I+ + GKAGE ++ RLR+ F+++++Q+ +FDDS+++
Sbjct: 760 SSMYSLLFLALGGVSFITFFLQRFTFGKAGEILTMRLRLGSFKSMLRQEIGWFDDSKNST 819
Query: 1253 GSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXX 1432
G+LT+RLATDA VQ A RLA + + +L + ++F YGW + +
Sbjct: 820 GALTTRLATDASQVQGATGTRLALLAQNVANLGTAIIISFIYGWQLTLLILAIVPVIAAA 879
Query: 1433 XXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRA 1612
++D +A ++ T+++ N +TV +LT++ + + + P+R +
Sbjct: 880 GLVEMKMFAGHAKKDKKELEKAGKISTDAVLNIRTVVSLTRERKFEAMYEKSLEGPYRNS 939
Query: 1613 IVRGLWQSLSFALAGSF----VMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMS 1780
I + L++ L+ + + W F++ G +L+ VF V A+ + +M+
Sbjct: 940 IKKAHLHGLTYGLSQAHHVLCLCWVFSV---LGAYLVVEGLMKLDEVFLVSSAIVLGAMA 996
Query: 1781 VMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYPNR 1957
+ +S+ P+Y +A ISA +F+++ + ID+ G+ P GN+ +GV F YP R
Sbjct: 997 LGQTSSFAPDYTKAMISAAHIFSLLERVPQIDSYSDQGEKPKNCSGNVVFKGVNFNYPTR 1056
Query: 1958 RRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVK 2137
VL G ++S G+T+ALVG SGCGKSTT+ L+ER+YD G V +D +R+L+++
Sbjct: 1057 PDITVLQGLDISVKQGETLALVGSSGCGKSTTVSLLERFYDPFEGEVLVDGLSVRNLNIQ 1116
Query: 2138 HLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYDT 2311
+R + +V QEP LF+ +I +NI YG N +TQ+++E AA ANIH+F+ L D Y+T
Sbjct: 1117 WVRAQMGIVSQEPILFDCSIGDNIAYGDNNRKVTQEEIETAAKEANIHSFIESLTDKYNT 1176
Query: 2312 SVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTC 2491
VG G +LSGGQKQR+AIARA++R PKILLLDEATSALDTESEK+VQEALDKAR+GRTC
Sbjct: 1177 RVGDKGTQLSGGQKQRIAIARALIRKPKILLLDEATSALDTESEKVVQEALDKARMGRTC 1236
Query: 2492 VVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
+VIAHRLSTIQNADKI V +NGK +E+GTHQ LL +G+Y+ LV Q
Sbjct: 1237 IVIAHRLSTIQNADKIAVIQNGKVVEQGTHQQLLQLKGVYFSLVTIQ 1283
Score = 330 bits (845), Expect = 1e-88
Identities = 200/595 (33%), Positives = 329/595 (54%), Gaps = 18/595 (3%)
Frame = +2
Query: 905 EASLFDIFKYASPEMRNIII-SLVFTLIRGFTWPAFSIVYGQLF-KILSAGGDDV---SI 1069
+ +F +F+Y+S + +++ + +L G P +V+G++ ++ G D +
Sbjct: 48 KVGVFTMFRYSSTSDKMLMLFGTIASLAHGAALPLMMLVFGEMTDSFVNVGQVDTGNFTW 107
Query: 1070 KALLNS------------LWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQ 1213
++++N+ ++ L F + I S + ++R + F +++
Sbjct: 108 ESMINASRELQGQMTTYAYYYSGLGFGVMLCAYIQISFWTLSAGRQIKKIRSNFFHAVLR 167
Query: 1214 QDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMA 1393
Q+ +FD + + G L +RL D + I ++A +L + +L G + F GW +
Sbjct: 168 QEIGWFDIN--DAGELNTRLTDDVSKINEGIGDKIAMLLQSLTTLVTGFIIGFIKGWKLT 225
Query: 1394 PIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYD 1573
+ L +++ + +A + E +S+ +TV A Q
Sbjct: 226 WVMGAISPIMGLSAAIWAKVLSAFTNKELKAYAKAGAVAEEVLSSIRTVFAFGGQNKEIH 285
Query: 1574 AFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVI 1753
+ + + I + + ++S A + +++A+ +G LI + T +V V
Sbjct: 286 RYEKNLEDAKKIGIKKAITANVSIGFAFLMIYAAYSLAFWYGTTLIIDGGYTIGSVLTVF 345
Query: 1754 EALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMR 1930
A+ + + +V + + AR +A +F +I + ID+ G P IKG+I +
Sbjct: 346 FAVIIGAFAVGQTSPNIEAFANARGAAYTIFNIIDNQPKIDSFSKEGLKPDKIKGDIEFK 405
Query: 1931 GVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDD 2110
V F YP+R+ VL G N++ G+TVALVG SGCGKSTT+QLI+R+YD G + +D
Sbjct: 406 NVIFTYPSRKDIQVLKGLNLNIPSGKTVALVGSSGCGKSTTVQLIQRFYDPEDGVITLDG 465
Query: 2111 SDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMG 2290
DIR L++++LR+ I +V QEP LF+ TI +NI YG E++T++++E+A AN + F+M
Sbjct: 466 QDIRSLNIRYLREIIGVVSQEPILFDTTIADNIRYGREDVTKEEIERATKEANAYDFIMK 525
Query: 2291 LPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDK 2470
LPD +T VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +VQ ALDK
Sbjct: 526 LPDKLETLVGERGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQSALDK 585
Query: 2471 ARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
AR GRT +V+AHRLSTI+NA+ I NG +E+G+H+ L+ R G+Y+ LV Q+
Sbjct: 586 AREGRTTIVVAHRLSTIRNANAIAGFDNGVIVEQGSHKELMERGGVYFNLVTLQT 640
>gi|39587992|emb|CAE57223.1| Hypothetical protein CBG00086
[Caenorhabditis briggsae]
Length = 1316
Score = 665 bits (1716), Expect = 0.0
Identities = 370/886 (41%), Positives = 537/886 (59%), Gaps = 11/886 (1%)
Frame = +2
Query: 8 KILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWLR 187
K+L G++ + PG +VALVGHSGCGKSTS+GLL R Y Q G + +DG ++ NI WLR
Sbjct: 433 KVLNGLNLTIEPGTSVALVGHSGCGKSTSVGLLTRLYEQEDGKVMIDGHEVRNLNIDWLR 492
Query: 188 STIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIGAG 367
+GIVQQEPI+F T+ N+ +G+ T D+ CKMANAHEFI K+ YDTVIG G
Sbjct: 493 KVVGIVQQEPILFSGTIHNNLLIGNPNATRDDMIRVCKMANAHEFILKMPKGYDTVIGDG 552
Query: 368 AVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIAH 547
VQLSGGQKQRVAIAR ++R P++LLLDEATSALD +SE +VQ+AL+ AS+GRTT+ IAH
Sbjct: 553 GVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALNNASKGRTTIMIAH 612
Query: 548 RLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQE----------IERAXX 697
RLSTIR A KI+ F+ G+I E GTHDEL++ G YA++VKAQ+ +E
Sbjct: 613 RLSTIREADKIVFFESGVIVESGTHDELVALG-GRYAALVKAQQFKEADEVDDDVEEDIT 671
Query: 698 XXXXXXXXXXXXHRSFHRDSVT-SDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXX 874
S+H V+ + + E+ + A +S L+Q+ +
Sbjct: 672 ARIFSEKQMPSRQVSYHGSCVSLASADLEIGYASAFNSFNLKQAQDDIENE---DFAEEV 728
Query: 875 XXXXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGG 1054
G + + +DIFK A + + VF ++RG +I++G +F+
Sbjct: 729 QRVMEEDGVITSGYYDIFKNAKGNYWYLSMGTVFAIMRGSELALLAIMFGYVFEAFEKPD 788
Query: 1055 DDVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFD 1234
+++ + ++ + + L I+ ++S +L E + + R+ F+N++ QDAS+FD
Sbjct: 789 AEMARELVIIFILYGCLGLYVFITQVLSSTLFTIVAENLGLKFRVQSFKNLLYQDASFFD 848
Query: 1235 DSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXX 1414
+ H G L +RLATDAPNV+A +D R+ +V+ + S+ + + W +A +G
Sbjct: 849 NPAHAPGKLITRLATDAPNVKAVVDTRMLQVIYSMTSITINLVTGYACCWQIAVVGTVMI 908
Query: 1415 XXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASK 1594
Y R EA ++ E + N KT+Q LT E+ +T A +
Sbjct: 909 ALFALLMISMA-YKIARVNLKQIKRDEAGKIAIEIVENVKTIQLLTSTEHFLTEYTTALE 967
Query: 1595 SPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMAS 1774
H+ + + Q+L+ A++ +F+ + + Y G L+ N P F+ I ++ M S
Sbjct: 968 LQHKSEMKKAYIQALNNAISQTFMYFAMFVCYAVGTPLMYNGIVDPNGAFRAINSMMMGS 1027
Query: 1775 MSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPN 1954
++VM ++ FPE+V+A+ +AG++F +I +K + + G+ I+GNI V F+YP
Sbjct: 1028 VAVMHSSHNFPEFVKAKTAAGMLFKLIYRKPKTGDV-MKGNQLDIRGNILFESVKFSYPQ 1086
Query: 1955 RRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSV 2134
R V+ + +A GQTVALVGPSG GKST I ++ER+YD G+++ID DI+ LS+
Sbjct: 1087 RPLHPVMTDLHFTARNGQTVALVGPSGTGKSTCIAMLERFYDVSGGALRIDGQDIKTLSL 1146
Query: 2135 KHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTS 2314
HLR +ALVGQEP LF TIREN+ +GL+++ ++V +A LAN F+ LP G DT
Sbjct: 1147 HHLRTQMALVGQEPRLFAGTIRENVCFGLKDVPIEKVNQALELANASRFLANLPSGIDTE 1206
Query: 2315 VGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCV 2494
VG G +LSGGQKQR+AIARA+VRDPKILLLDEATSALD+ESE+++QEALD+AR GRTC+
Sbjct: 1207 VGEKGSQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERVMQEALDRAREGRTCI 1266
Query: 2495 VIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
IAHRLS+IQN+D I+ GK E G H L++ RG YY L++KQ
Sbjct: 1267 TIAHRLSSIQNSDLIVYIDQGKVQEAGNHNHLMSLRGKYYDLIKKQ 1312
Score = 303 bits (775), Expect = 2e-80
Identities = 193/587 (32%), Positives = 312/587 (52%), Gaps = 13/587 (2%)
Frame = +2
Query: 911 SLFDIFKYASPEMRN---IIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALL 1081
+L +F++A E R+ ++I ++ + + G P ++ G + L +V+ L
Sbjct: 77 TLLGLFRFA--ERRDHIILLIGILLSFLSGVAQPGLGVIAGGMTNTLIVY--NVTSPQFL 132
Query: 1082 NSLWFILLAFTG-GISTLISGSLLGKAGETMSGR----LRMDVFRNIMQQDASYFDDSRH 1246
+S + F G G+ LI + + + R LR + ++I++Q+A +FD ++
Sbjct: 133 DSALMNVYLFGGIGVVVLIINFIQYMCFQNVCIRIVTKLREEYIKSILRQNAGWFD--KN 190
Query: 1247 NVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXX 1426
+ G+LT++L + + I +L ++ GIV G+ ++ +Y W +A +
Sbjct: 191 HSGTLTTKLHDNMERIHEGIGDKLGVLIRGIVMFGTGIVISLFYEWRLALMMMGIGPLCC 250
Query: 1427 XXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHR 1606
+ +++ +A + ES+ +TVQA QE M +TA
Sbjct: 251 ICMSLMSRSMSSYTSKELADVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYTAELGKGKS 310
Query: 1607 RAIVRGLWQSLSFALAGSFVMWNFAIAYMFG----LWLISNNWSTPYTVFQVIEALNMAS 1774
A+ +GLW + + F +G W I N P VF V+ ++ + +
Sbjct: 311 YAVKKGLWGGFFGGIFLLILFTYFGGGIFYGGQLLRWKIIEN---PGDVFIVVFSMLIGA 367
Query: 1775 MSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDT-PTIKGNINMRGVYFAYP 1951
+ L + + + AR++A ++ +I + ID G I G + V+F YP
Sbjct: 368 YFLGLISPHLMVLLNARVAAATIYEVIDRVPEIDAYSNEGQKIDKIVGRVVFENVHFRYP 427
Query: 1952 NRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLS 2131
R++ VL+G N++ G +VALVG SGCGKST++ L+ R Y+ G V ID ++R+L+
Sbjct: 428 TRKKAKVLNGLNLTIEPGTSVALVGHSGCGKSTSVGLLTRLYEQEDGKVMIDGHEVRNLN 487
Query: 2132 VKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDT 2311
+ LR + +V QEP LF+ TI N+ G N T+D + + +AN H F++ +P GYDT
Sbjct: 488 IDWLRKVVGIVQQEPILFSGTIHNNLLIGNPNATRDDMIRVCKMANAHEFILKMPKGYDT 547
Query: 2312 SVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTC 2491
+G G +LSGGQKQRVAIAR ++RDPK+LLLDEATSALD +SE +VQ AL+ A GRT
Sbjct: 548 VIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALNNASKGRTT 607
Query: 2492 VVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
++IAHRLSTI+ ADKI+ +G +E GTH L+A G Y LV+ Q
Sbjct: 608 IMIAHRLSTIREADKIVFFESGVIVESGTHDELVALGGRYAALVKAQ 654
>gi|25453370|ref|NP_036755.2| P-glycoprotein/multidrug resistance 1;
ATP-binding cassette, sub-family B (MDR/TAP), member 1
(P-glycoprotein/multidrug resistance 1); ATP-binding
cassette sub-family B (MDR/TAP) member 1
(P-glycoprotein/multidrug resistance 1) [Rattus
norvegicus]
gi|19743730|gb|AAL92458.1| ATP-binding cassette protein B1b [Rattus
norvegicus]
Length = 1275
Score = 665 bits (1715), Expect = 0.0
Identities = 372/886 (41%), Positives = 544/886 (60%), Gaps = 11/886 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
E+KILKG++ +V G+TVALVG+SGCGKST++ LL R Y+ G + +DG I+ N+R+
Sbjct: 404 EVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIRTINVRY 463
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR IG+V QEP++F T+AENIR G +T +IE+A K ANA++FI KL +++T++G
Sbjct: 464 LREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFNTLVG 523
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA EGRTT+ I
Sbjct: 524 ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVI 583
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ----EIERAXXXXXX 709
AHRLST+RNA I FD G+I E+G H+EL+ K+ GIY +V Q EIE
Sbjct: 584 AHRLSTVRNADVIAGFDGGVIVEQGNHEELM-KEKGIYFKLVMTQTRGNEIEPGNNAYES 642
Query: 710 XXXXXXXXHRSFHRDSVTSDEERELQQSLAR--DSTRLRQSMISTTTQVPXXXXXXXXXX 883
S S + R +++S+ R D R S VP
Sbjct: 643 QSDTGASELTS--EKSKSPLIRRSIRRSIHRRQDQERRLSSKEDVDEDVPM--------- 691
Query: 884 XXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV 1063
S + I K E +++ ++ +I G P F+IV+ ++ + S D
Sbjct: 692 --------VSFWQILKLNISEWPYLVVGVLCAVINGCIQPVFAIVFSKIVGVFSRDDDHE 743
Query: 1064 SIKALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDD 1237
+ + N SL F+++ ++ G GKAGE ++ RLR VF+++++QD S+FDD
Sbjct: 744 TKQRNCNLFSLLFLVMGMISFVTYFFQGFAFGKAGEILTKRLRYMVFKSMLRQDISWFDD 803
Query: 1238 SRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXX 1417
++ GSLT+RLA+DA NV+ A+ RLA V + +L G+ ++ YGW + +
Sbjct: 804 HKNTTGSLTTRLASDASNVKGAMGSRLAVVTQNVANLGTGIILSLVYGWQLTLLLVVIIP 863
Query: 1418 XXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKS 1597
L + +D + ++ TE+I N++TV +LT+++ + + +
Sbjct: 864 LIVLGGIIEMKLLSGQALKDKKELEISGKIATEAIENFRTVVSLTREQKFETMYAQSLQI 923
Query: 1598 PHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASM 1777
P+R A+ + ++FA + + +++A + FG +L++ T V V A+ +M
Sbjct: 924 PYRNALKKAHVFGITFAFTQAMIYFSYAACFRFGAYLVARELMTFENVMLVFSAVVFGAM 983
Query: 1778 SVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFAYPN 1954
+ +S+ P+Y +A++SA + +I + ID+ G P ++GN+ GV F YP
Sbjct: 984 AAGNTSSFAPDYAKAKVSASHIIRIIEKIPEIDSYSTEGLKPNWLEGNVKFNGVMFNYPT 1043
Query: 1955 RRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSV 2134
R VL G + GQT+ALVG SGCGKST +QL+ER+Y+ + G+V +D +I+ L+V
Sbjct: 1044 RPNIPVLQGLSFEVKKGQTLALVGSSGCGKSTVVQLLERFYNPMAGTVFLDGKEIKQLNV 1103
Query: 2135 KHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYD 2308
+ LR ++ +V QEP LF+ +I ENI YG + ++ +++ +AA ANIH F+ LP+ Y+
Sbjct: 1104 QWLRAHLGIVSQEPILFDCSITENIAYGDNSRVVSHEEIVRAAREANIHQFIDSLPEKYN 1163
Query: 2309 TSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRT 2488
T VG G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GRT
Sbjct: 1164 TRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRT 1223
Query: 2489 CVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVE 2626
C+VIAHRLSTIQNAD I+V +NG+ E GTHQ LLA++G+Y+ +V+
Sbjct: 1224 CIVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMVQ 1269
Score = 335 bits (860), Expect = 3e-90
Identities = 189/487 (38%), Positives = 279/487 (56%), Gaps = 1/487 (0%)
Frame = +2
Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
++R F IM Q+ +FD + + G L +RL D + I +L I + G
Sbjct: 144 KIRQKFFHAIMNQEIGWFDVN--DAGELNTRLTDDVSKINDGIGDKLGMFFQSITTFSAG 201
Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
+ F GW + + L +++ + +A + E ++ +T
Sbjct: 202 FIIGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRT 261
Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
V A Q+ + + + R I + + ++S +A V ++A+A+ +G L+ +
Sbjct: 262 VIAFGGQKKELERYNKNLEEAKRVGIKKAITANISIGIAYLLVYASYALAFWYGTSLVLS 321
Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
N + V V ++ + + S+ A + AR +A +F +I + ID+ G
Sbjct: 322 NEYSIGQVLTVFFSILLGTFSIGHLAPNIEAFANARGAAYEIFKIIDNEPSIDSFSTKGH 381
Query: 1898 TP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
P +I GN+ + VYF YP+R +L G N+ GQTVALVG SGCGKSTT+QL++R
Sbjct: 382 KPDSIMGNLEFKNVYFNYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRL 441
Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
YD + G V ID DIR ++V++LR+ I +V QEP LF TI ENI YG EN+T D++EKA
Sbjct: 442 YDPIEGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKA 501
Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
AN + F+M LP ++T VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDT
Sbjct: 502 VKEANAYDFIMKLPHKFNTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 561
Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
ESE +VQ ALDKAR GRT +VIAHRLST++NAD I G +E+G H+ L+ +G+Y+
Sbjct: 562 ESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIYF 621
Query: 2615 RLVEKQS 2635
+LV Q+
Sbjct: 622 KLVMTQT 628
>gi|25453402|ref|NP_596892.1| ATP-binding cassette, sub-family B
(MDR/TAP), member 1A; multiple drug resistant 1a [Rattus
norvegicus]
gi|34853968|ref|XP_346684.1| hypothetical protein XP_346683 [Rattus
norvegicus]
gi|7739773|gb|AAF69007.1| multidrug resistance protein 1a [Rattus
norvegicus]
Length = 1272
Score = 665 bits (1715), Expect = 0.0
Identities = 375/888 (42%), Positives = 545/888 (61%), Gaps = 10/888 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
+++ILKG++ +V G+TVALVG+SGCGKST++ LL R Y+ G + +DG I+ N+R+
Sbjct: 398 DVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIRTINVRY 457
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR IG+V QEP++F T+AENIR G +T +IE+A K ANA++FI KL ++DT++G
Sbjct: 458 LREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVG 517
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA EGRTT+ I
Sbjct: 518 ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVI 577
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ----EIERAXXXXXX 709
AHRLST+RNA I FD G+I E+G HDEL+ ++ GIY +V Q EIE
Sbjct: 578 AHRLSTVRNADVIAGFDGGVIVEQGNHDELM-REKGIYFKLVMTQTAGNEIELGNEACES 636
Query: 710 XXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXX 889
D+V + + R STR +S+ Q
Sbjct: 637 KDGI----------DNVDMSSKDSGSSLIRRRSTR--KSIRGPHDQ----DGELSTKEAL 680
Query: 890 XXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSI 1069
AS + I K S E ++ + +I G PAFSI++ ++ + + D I
Sbjct: 681 DDDVPPASFWRILKLNSTEWPYFVVGVFCAIINGGLQPAFSIIFSKVVGVFTKN-DTPEI 739
Query: 1070 K---ALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDS 1240
+ + L SL F++L I+ + G GKAGE ++ RLR VF+++++QD S+FDD
Sbjct: 740 QRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDP 799
Query: 1241 RHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXX 1420
++ G+LT+RLA DA V+ A RLA + I +L G+ ++ YGW + +
Sbjct: 800 KNTTGALTTRLANDAAQVKGATGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPI 859
Query: 1421 XXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSP 1600
L + +D + ++ TE+I N++TV +LT+++ + + + P
Sbjct: 860 IAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIP 919
Query: 1601 HRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMS 1780
+R A+ + ++F+ + + +++A + FG +L++ T V V A+ +M+
Sbjct: 920 YRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGAMA 979
Query: 1781 VMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFAYPNR 1957
V +S+ P+Y +A++SA + +I + ID+ G P ++GN+ GV F YP R
Sbjct: 980 VGQVSSFAPDYAKAKVSASHIIRIIEKIPEIDSYSTEGLKPNMLEGNVKFNGVMFNYPTR 1039
Query: 1958 RRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVK 2137
VL G ++ GQT+ALVG SGCGKST +QL+ER+YD + G+V +D +I+ L+V+
Sbjct: 1040 PNIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEIKQLNVQ 1099
Query: 2138 HLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYDT 2311
LR ++ +V QEP LF+ +I ENI YG + ++ +++ KAA ANIH F+ LP+ Y+T
Sbjct: 1100 WLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIVKAAKEANIHQFIDSLPEKYNT 1159
Query: 2312 SVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTC 2491
VG G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GRTC
Sbjct: 1160 RVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTC 1219
Query: 2492 VVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
+VIAHRLSTIQNAD I+V +NG+ E GTHQ LLA++G+Y+ +V Q+
Sbjct: 1220 IVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMVSVQA 1267
Score = 346 bits (888), Expect = 1e-93
Identities = 211/592 (35%), Positives = 323/592 (53%), Gaps = 16/592 (2%)
Frame = +2
Query: 911 SLFDIFKYASPEMR-NIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIK----- 1072
S+ +F+YA R +++ + +I G P +V+G + + G++ S+
Sbjct: 34 SVLTMFRYAGWLDRFYMLLGTLAAIIHGIALPLMMLVFGDMTDSFANVGNNRSMSFYNAT 93
Query: 1073 ----ALLNSLWFILLAFTG-GISTLISG----SLLGKAGETMSGRLRMDVFRNIMQQDAS 1225
L + + +TG G LI SL A ++R F IM Q+
Sbjct: 94 DIYAKLEDEMTTYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIG 153
Query: 1226 YFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGX 1405
+FD H+VG L +RL D + I ++ + + F G + F GW + +
Sbjct: 154 WFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVIL 211
Query: 1406 XXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTA 1585
L +++ + +A + E ++ +TV A Q+ + +
Sbjct: 212 AISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNN 271
Query: 1586 ASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALN 1765
+ R I + + ++S A + ++A+A+ +G L+ + T V V ++
Sbjct: 272 NLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYTIGQVLTVFFSVL 331
Query: 1766 MASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYF 1942
+ + SV A+ + AR +A +F++I K ID+ +G P I+GN+ + ++F
Sbjct: 332 IGAFSVGQASPNIEAFANARGAAYEVFSIIDNKPSIDSFSKSGHKPDNIQGNLEFKNIHF 391
Query: 1943 AYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIR 2122
+YP+R+ +L G N+ GQTVALVG SGCGKSTT+QL++R YD + G V ID DIR
Sbjct: 392 SYPSRKDVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIR 451
Query: 2123 DLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDG 2302
++V++LR+ I +V QEP LF TI ENI YG EN+T D++EKA AN + F+M LP
Sbjct: 452 TINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHK 511
Query: 2303 YDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLG 2482
+DT VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +VQ ALDKAR G
Sbjct: 512 FDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREG 571
Query: 2483 RTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
RT +VIAHRLST++NAD I G +E+G H L+ +G+Y++LV Q++
Sbjct: 572 RTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTA 623
>gi|46394986|gb|AAS91649.1| multidrug resistance protein 1a;
P-glycoprotein [Rattus norvegicus]
Length = 1272
Score = 665 bits (1715), Expect = 0.0
Identities = 375/888 (42%), Positives = 545/888 (61%), Gaps = 10/888 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
+++ILKG++ +V G+TVALVG+SGCGKST++ LL R Y+ G + +DG I+ N+R+
Sbjct: 398 DVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIRTINVRY 457
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR IG+V QEP++F T+AENIR G +T +IE+A K ANA++FI KL ++DT++G
Sbjct: 458 LREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVG 517
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA EGRTT+ I
Sbjct: 518 ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVI 577
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ----EIERAXXXXXX 709
AHRLST+RNA I FD G+I E+G HDEL+ ++ GIY +V Q EIE
Sbjct: 578 AHRLSTVRNADVIAGFDGGVIVEQGNHDELM-REKGIYFKLVMTQTAGNEIELGNEACES 636
Query: 710 XXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXX 889
D+V + + R STR +S+ Q
Sbjct: 637 KDGI----------DNVDMSSKDSGSSLIRRRSTR--KSIRGPHDQ----DGELSTKEAL 680
Query: 890 XXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSI 1069
AS + I K S E ++ + +I G PAFSI++ ++ + + D I
Sbjct: 681 DDDVPPASFWRILKLNSTEWPYFVVGVFCAIINGGLQPAFSIIFSKVVGVFTKN-DTPEI 739
Query: 1070 K---ALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDS 1240
+ + L SL F++L I+ + G GKAGE ++ RLR VF+++++QD S+FDD
Sbjct: 740 QRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDP 799
Query: 1241 RHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXX 1420
++ G+LT+RLA DA V+ A RLA + I +L G+ ++ YGW + +
Sbjct: 800 KNTTGALTTRLANDAAQVKGATGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPI 859
Query: 1421 XXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSP 1600
L + +D + ++ TE+I N++TV +LT+++ + + + P
Sbjct: 860 IAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIP 919
Query: 1601 HRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMS 1780
+R A+ + ++F+ + + +++A + FG +L++ T V V A+ +M+
Sbjct: 920 YRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGAMA 979
Query: 1781 VMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFAYPNR 1957
V +S+ P+Y +A++SA + +I + ID+ G P ++GN+ GV F YP R
Sbjct: 980 VGQVSSFAPDYAKAKVSASHIIRIIEKIPEIDSYSTEGLKPNMLEGNVKFNGVMFNYPTR 1039
Query: 1958 RRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVK 2137
VL G ++ GQT+ALVG SGCGKST +QL+ER+YD + G+V +D +I+ L+V+
Sbjct: 1040 PNIPVLQGLSLEGKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEIKQLNVQ 1099
Query: 2138 HLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYDT 2311
LR ++ +V QEP LF+ +I ENI YG + ++ +++ KAA ANIH F+ LP+ Y+T
Sbjct: 1100 WLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIVKAAKEANIHQFIDSLPEKYNT 1159
Query: 2312 SVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTC 2491
VG G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GRTC
Sbjct: 1160 RVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTC 1219
Query: 2492 VVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
+VIAHRLSTIQNAD I+V +NG+ E GTHQ LLA++G+Y+ +V Q+
Sbjct: 1220 IVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMVSVQA 1267
Score = 347 bits (889), Expect = 1e-93
Identities = 211/592 (35%), Positives = 323/592 (53%), Gaps = 16/592 (2%)
Frame = +2
Query: 911 SLFDIFKYASPEMR-NIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIK----- 1072
S+ +F+YA R +++ + +I G P +V+G + + G++ S+
Sbjct: 34 SVLTMFRYAGWLDRFYMLLGTLAAIIHGIALPLMMLVFGDMTDSFANVGNNRSMSFYNAT 93
Query: 1073 ----ALLNSLWFILLAFTG-GISTLISG----SLLGKAGETMSGRLRMDVFRNIMQQDAS 1225
L + + +TG G LI SL A ++R F IM Q+
Sbjct: 94 DIYAKLKDEMTTYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIG 153
Query: 1226 YFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGX 1405
+FD H+VG L +RL D + I ++ + + F G + F GW + +
Sbjct: 154 WFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVIL 211
Query: 1406 XXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTA 1585
L +++ + +A + E ++ +TV A Q+ + +
Sbjct: 212 AISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNN 271
Query: 1586 ASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALN 1765
+ R I + + ++S A + ++A+A+ +G L+ + T V V ++
Sbjct: 272 NLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYTIGQVLTVFFSVL 331
Query: 1766 MASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYF 1942
+ + SV A+ + AR +A +F++I K ID+ +G P I+GN+ + ++F
Sbjct: 332 IGAFSVGQASPNIEAFANARGAAYEVFSIIDNKPSIDSFSKSGHKPDNIQGNLEFKNIHF 391
Query: 1943 AYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIR 2122
+YP+R+ +L G N+ GQTVALVG SGCGKSTT+QL++R YD + G V ID DIR
Sbjct: 392 SYPSRKDVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIR 451
Query: 2123 DLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDG 2302
++V++LR+ I +V QEP LF TI ENI YG EN+T D++EKA AN + F+M LP
Sbjct: 452 TINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHK 511
Query: 2303 YDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLG 2482
+DT VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +VQ ALDKAR G
Sbjct: 512 FDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREG 571
Query: 2483 RTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
RT +VIAHRLST++NAD I G +E+G H L+ +G+Y++LV Q++
Sbjct: 572 RTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTA 623
>gi|7511698|pir||T31073 multidrug resistance p-glycoprotein - nematode
(Haemonchus contortus)
gi|3057042|gb|AAC38987.1| P-glycoprotein [Haemonchus contortus]
Length = 1275
Score = 664 bits (1714), Expect = 0.0
Identities = 367/880 (41%), Positives = 537/880 (60%), Gaps = 4/880 (0%)
Frame = +2
Query: 5 LKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWL 184
L+ILKGVS +V+ G+ +ALVG SGCGKST++ LL+RFY+ G + +D I + + N++ L
Sbjct: 408 LQILKGVSLQVSAGQKIALVGSSGCGKSTNVNLLLRFYDPTRGKVTIDDIDVCDLNVQKL 467
Query: 185 RSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIGA 364
R IG+V QEP++F T+ ENI+MG T ++++EAC++ANA +F +L + Y T +G
Sbjct: 468 REQIGVVSQEPVLFDGTLFENIKMGYEQATMEEVQEACRVANAADFTKRLPEGYGTRVGE 527
Query: 365 GAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIA 544
VQLSGGQKQR+AIARAI++ P+ILLLDEATSALDTE+E +VQ AL+KA +GRTT+ +A
Sbjct: 528 RGVQLSGGQKQRIAIARAIIKNPRILLLDEATSALDTEAESIVQEALEKAQKGRTTVIVA 587
Query: 545 HRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXXX 724
HRLSTIRN +I VF G I E+GTH EL++K G++ M +AQ + +
Sbjct: 588 HRLSTIRNVDQIFVFKNGTIVEQGTHAELMNKR-GVFFEMTQAQVLRQEKEEEVLDSDAE 646
Query: 725 XXXHRSFHRDSVTSDEERELQQSLA--RDSTRLRQSMISTTTQVPXXXXXXXXXXXXXXG 898
D V+ D SL ++STR S + + +
Sbjct: 647 S--------DVVSPDIALPHLSSLRSRKESTRSAISAVPSVRSMQIEMEDLR-------- 690
Query: 899 AMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKAL 1078
A + IF + + I+ L+ +I G P F+++Y Q+ ++ S D + L
Sbjct: 691 AKPTPMSKIFYFNRDKWGYFILGLIACIITGTVTPTFAVLYAQIIQVYSEPVDQMKGHVL 750
Query: 1079 LNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGS 1258
FI++ + S LG+ GE ++ +LR + F+N+++Q+ ++DD RH G
Sbjct: 751 FWCGAFIVIGLVHAFAFFFSAICLGRCGEALTKKLRFEAFKNLLRQNVGFYDDIRHGTGK 810
Query: 1259 LTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXX 1438
L +R ATDAPNV+ RL VL+ +V++ + + F +GW +A I
Sbjct: 811 LCTRFATDAPNVRYVFT-RLPGVLSSVVTIIGALVIGFIFGWQLALILMVMVPLIIGSGY 869
Query: 1439 XXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIV 1618
+ RD + EA ++ ++++ N +TV AL +QE + + K P+R +
Sbjct: 870 FEMRMQFGKKMRDTELLEEAGKVASQAVENIRTVHALNRQEQFHFMYCEYLKEPYRENLC 929
Query: 1619 RGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAAS 1798
+ FA + S + + +A+A+ G + N+ P V++V A V +S
Sbjct: 930 QAHTYGGVFAFSQSLLFFMYAVAFWIGAIFVDNHSMQPIDVYRVFFAFMFCGQMVGNISS 989
Query: 1799 YFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVLD 1978
+ P+ V+AR++A ++F +I S IDN G T I G+I+ R VYF YP RR+ VL
Sbjct: 990 FIPDVVKARLAASLLFYLIEHPSEIDNLSEDGVTKKISGHISFRNVYFNYPTRRQIRVLR 1049
Query: 1979 GFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIA 2158
G N+ N G TVALVG SGCGKST + L+ER+Y+ G + +D +IR++++++LR+ +
Sbjct: 1050 GLNLEINPGTTVALVGQSGCGKSTVMALLERFYNQNKGVITVDGENIRNMNIRNLREQVC 1109
Query: 2159 LVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGG 2332
+V QEPTLF+ TI ENI YGL++ + +QV AA +ANIH FV+GLP+GYDT VG G
Sbjct: 1110 IVSQEPTLFDCTIMENICYGLDDPKPSYEQVVAAAKMANIHNFVLGLPEGYDTRVGEKGT 1169
Query: 2333 RLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRL 2512
+LSGGQKQR+AIARA++RDP ILLLDEATSALDTESEKIVQ+AL+ AR GRTC+VIAHRL
Sbjct: 1170 QLSGGQKQRIAIARALIRDPPILLLDEATSALDTESEKIVQDALEVARQGRTCLVIAHRL 1229
Query: 2513 STIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
STIQ++D I++ + GKA + GTH+ LL + LY RL E Q
Sbjct: 1230 STIQDSDVIVMIQEGKATDRGTHEHLLMKNDLYKRLCETQ 1269
Score = 313 bits (803), Expect = 1e-83
Identities = 182/517 (35%), Positives = 291/517 (56%), Gaps = 2/517 (0%)
Frame = +2
Query: 1088 LWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSLTS 1267
L+++ L F ++ I E ++ +LR + I++Q S+FD + G+LT+
Sbjct: 116 LYYLGLGFAMFATSYIQIVCWETFAERITHKLRKIYLKAILRQQISWFDIQQ--TGNLTA 173
Query: 1268 RLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXXXXX 1447
RL D V+ + +L+ + + + G V F Y W+M +
Sbjct: 174 RLTDDLERVREGLGDKLSLFIQMVSAFVAGFCVGFAYSWSMTLVMMVVAPFIVISANWMS 233
Query: 1448 XYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVRGL 1627
+ R Q + ++ A + E+ S+ +TV ++ + F AA + + +V+
Sbjct: 234 KIVATRTQVEQETYAVAGAIAEETFSSIRTVHSICGHKRELTRFEAALEKGRQTGLVKYF 293
Query: 1628 WQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPY-TVFQVIEALNMASMSVMLAASYF 1804
+ + ++A+A+ +G LI N+ + +F V A+ S ++ +
Sbjct: 294 YMGVGVGFGQMCTYVSYALAFWYGSVLIINDPALDRGRIFTVFFAVMSGSAALGTCLPHL 353
Query: 1805 PEYVRARISAGIMFTMIRQKSVIDNRGLTGDT-PTIKGNINMRGVYFAYPNRRRQLVLDG 1981
AR + + ++I + ID L G ++G+I + V+F+YP+RR +L G
Sbjct: 354 NTISIARGAVRSVLSVINSRPKIDPYSLDGIVLNNMRGSIRFKNVHFSYPSRRTLQILKG 413
Query: 1982 FNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIAL 2161
++ + GQ +ALVG SGCGKST + L+ R+YD G V IDD D+ DL+V+ LR+ I +
Sbjct: 414 VSLQVSAGQKIALVGSSGCGKSTNVNLLLRFYDPTRGKVTIDDIDVCDLNVQKLREQIGV 473
Query: 2162 VGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRLS 2341
V QEP LF+ T+ ENI G E T ++V++A +AN F LP+GY T VG G +LS
Sbjct: 474 VSQEPVLFDGTLFENIKMGYEQATMEEVQEACRVANAADFTKRLPEGYGTRVGERGVQLS 533
Query: 2342 GGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTI 2521
GGQKQR+AIARAI+++P+ILLLDEATSALDTE+E IVQEAL+KA+ GRT V++AHRLSTI
Sbjct: 534 GGQKQRIAIARAIIKNPRILLLDEATSALDTEAESIVQEALEKAQKGRTTVIVAHRLSTI 593
Query: 2522 QNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
+N D+I V +NG +E+GTH L+ +RG+++ + + Q
Sbjct: 594 RNVDQIFVFKNGTIVEQGTHAELMNKRGVFFEMTQAQ 630
Score = 229 bits (584), Expect = 3e-58
Identities = 120/229 (52%), Positives = 162/229 (70%), Gaps = 2/229 (0%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
++++L+G++ E+NPG TVALVG SGCGKST + LL RFYNQ G+I +DG I+ NIR
Sbjct: 1044 QIRVLRGLNLEINPGTTVALVGQSGCGKSTVMALLERFYNQNKGVITVDGENIRNMNIRN 1103
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMG--DVLITDQDIEEACKMANAHEFICKLSDRYDTV 355
LR + IV QEP +F T+ ENI G D + + + A KMAN H F+ L + YDT
Sbjct: 1104 LREQVCIVSQEPTLFDCTIMENICYGLDDPKPSYEQVVAAAKMANIHNFVLGLPEGYDTR 1163
Query: 356 IGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTL 535
+G QLSGGQKQR+AIARA++R P ILLLDEATSALDTESE++VQ AL+ A +GRT L
Sbjct: 1164 VGEKGTQLSGGQKQRIAIARALIRDPPILLLDEATSALDTESEKIVQDALEVARQGRTCL 1223
Query: 536 CIAHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEI 682
IAHRLSTI+++ I++ +G +RGTH+ L+ K+D +Y + + Q +
Sbjct: 1224 VIAHRLSTIQDSDVIVMIQEGKATDRGTHEHLLMKND-LYKRLCETQRL 1271
>gi|48267183|gb|AAQ63650.3| multi-drug resistance P-glycoprotein 1;
PGY1; MDR1; GP170; ABC20; P-GP [Oryctolagus cuniculus]
Length = 1279
Score = 664 bits (1714), Expect = 0.0
Identities = 368/886 (41%), Positives = 543/886 (60%), Gaps = 8/886 (0%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
E+KILKG++ +V G+TVALVG+SGCGKST++ L+ R Y+ G++ +DG I+ N+R+
Sbjct: 404 EVKILKGLNLKVESGQTVALVGNSGCGKSTTVQLMRRLYDPTDGVVSIDGQDIRTMNVRY 463
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR G+V QEP++F T+AEN+R G +T +IE+A K ANA+ FI KL ++DT++G
Sbjct: 464 LREITGVVSQEPVLFATTIAENVRYGREDVTMDEIEKAVKEANAYNFIMKLPHKFDTLVG 523
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA +GRTT+ I
Sbjct: 524 ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVI 583
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
AHRLST+RNA I FD G+I ERG H+EL+ + G+Y +V Q
Sbjct: 584 AHRLSTVRNADVIAGFDNGVIVERGNHEELM-RQKGVYFRLVTMQTAGNEIDLENSA--- 639
Query: 722 XXXXHRSFHRDSVTSDEERELQQSLARDSTRL---RQSMISTTTQVPXXXXXXXXXXXXX 892
S + E+ +L + A++S R+S +
Sbjct: 640 -----------SESRGEKMDLVEMSAKESGSSLIRRRSSHKSFHGAQGQDGKLSTTEAQN 688
Query: 893 XGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIK 1072
S + I K E ++ ++ +I G PAF++V+ ++ + + DD + +
Sbjct: 689 ENVPPVSFWRIMKLNLTEWPYFLVGVICAIINGGLQPAFAVVFSKIVGVFTRNDDDETKR 748
Query: 1073 --ALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRH 1246
+ L SL F++L I+ + G GKAGE ++ RLR VF+++++QD S+FDD ++
Sbjct: 749 RNSDLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKN 808
Query: 1247 NVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXX 1426
G+LT+RLA DA V+ A RLA + I +L G+ ++ YGW + +
Sbjct: 809 TTGALTTRLANDAAQVKGATGSRLAVIAQNIANLGTGIIISLVYGWQLTLLLLAIVPIIA 868
Query: 1427 XXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHR 1606
L + +D + ++ TE+I N++TV +LT+++ + + + + P+R
Sbjct: 869 IAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFENMYAQSLQVPYR 928
Query: 1607 RAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVM 1786
++ + ++F+ + + +++A + FG +L++ + V V A+ +M+V
Sbjct: 929 NSLEKAHIFGITFSFTQAMMYFSYAGCFRFGAFLVARELMSFENVLLVFSAVVFGAMAVG 988
Query: 1787 LAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYPNRRR 1963
+S+ P+Y +A+ISA + ++ + ID+ G P T++GN+ + V F YP R
Sbjct: 989 QVSSFAPDYAKAKISASHIIMILEKLPKIDSYSTEGLKPGTLEGNMTFKDVVFNYPTRPD 1048
Query: 1964 QLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHL 2143
VL G N+ GQT+ALVGPSGCGKST +QLIER+YD L G+V +D ++ L+V+ L
Sbjct: 1049 IPVLQGLNLQVKKGQTLALVGPSGCGKSTVVQLIERFYDPLAGTVLLDGKEVNQLNVQWL 1108
Query: 2144 RDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYDTSV 2317
R ++ +V QEP LF+ +I ENI YG + ++QD++ KAA ANIH F+ LPD Y+T V
Sbjct: 1109 RAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIIKAAKEANIHAFIDSLPDKYNTRV 1168
Query: 2318 GASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVV 2497
G G +LSGGQKQR+AIARA+VR P ILLLDEATSA DTESEK+VQEALDKAR GRTCVV
Sbjct: 1169 GDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSAPDTESEKVVQEALDKAREGRTCVV 1228
Query: 2498 IAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
IAHRLSTIQNAD I+V +NG+ E GTH LLA++G+Y+ +V Q+
Sbjct: 1229 IAHRLSTIQNADMIVVFQNGRVKECGTHHQLLAQKGIYFSMVSVQA 1274
Score = 332 bits (852), Expect = 2e-89
Identities = 205/599 (34%), Positives = 320/599 (53%), Gaps = 23/599 (3%)
Frame = +2
Query: 911 SLFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGD---------- 1057
S F +F+Y++ + +++ + +I G P +V+G + S G+
Sbjct: 33 SAFAMFRYSNWLDKLYMVVGTLAAIIHGAALPLMMLVFGDMTDSFSNPGNMIPANITNLN 92
Query: 1058 --DVSIKALLNSLWFILLAFTGGISTLISGSLLGK---------AGETMSGRLRMDVFRN 1204
++S + L + + S + +G L+ A + ++R F +
Sbjct: 93 MSNISASEIYEHLEEEMTTYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQTFKIRKQFFHS 152
Query: 1205 IMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGW 1384
IM+Q+ +FD H+VG L +RL D + I ++ + + F G V F GW
Sbjct: 153 IMRQEIGWFDV--HDVGELNTRLTDDVSKINDGIGDKIGMFFQSMSTFFTGFIVGFTRGW 210
Query: 1385 NMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEY 1564
+ + + +++ + +A + E ++ +TV A Q+
Sbjct: 211 KLTLVILAISPVLGLSAALWAKIMSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQQK 270
Query: 1565 MYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVF 1744
+ + + R I + + ++S +A + ++A+A+ + L + V
Sbjct: 271 ELERYNKNLEEAKRIGIKKAITANISVGVAFLLMYASYALAFWYWNHLGHLKEYSIGQVL 330
Query: 1745 QVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNI 1921
V ++ + + S+ A+ + AR +A +F +I ID+ G P IKGN+
Sbjct: 331 TVFFSVLVGAFSIGQASPNVEAFANARGAAYEIFRIIDNMPSIDSYSEAGHKPDNIKGNL 390
Query: 1922 NMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVK 2101
R V+F+YP+R+ +L G N+ GQTVALVG SGCGKSTT+QL+ R YD G V
Sbjct: 391 EFRNVHFSYPSRKEVKILKGLNLKVESGQTVALVGNSGCGKSTTVQLMRRLYDPTDGVVS 450
Query: 2102 IDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTF 2281
ID DIR ++V++LR+ +V QEP LF TI EN+ YG E++T D++EKA AN + F
Sbjct: 451 IDGQDIRTMNVRYLREITGVVSQEPVLFATTIAENVRYGREDVTMDEIEKAVKEANAYNF 510
Query: 2282 VMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEA 2461
+M LP +DT VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +VQ A
Sbjct: 511 IMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVA 570
Query: 2462 LDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
LDKAR GRT +VIAHRLST++NAD I NG +E G H+ L+ ++G+Y+RLV Q++
Sbjct: 571 LDKARKGRTTIVIAHRLSTVRNADVIAGFDNGVIVERGNHEELMRQKGVYFRLVTMQTA 629
>gi|50732589|ref|XP_418707.1| PREDICTED: similar to ATP-binding
cassette, sub-family B (MDR/TAP), member 1A; multiple
drug resistant 1a [Gallus gallus]
Length = 1734
Score = 659 bits (1700), Expect = 0.0
Identities = 369/885 (41%), Positives = 531/885 (59%), Gaps = 12/885 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
++ ILKG++ +V G+T+ALVG SGCGKST++ LL RFY+ G + LDG I+ N++W
Sbjct: 483 DITILKGLNLKVQTGKTIALVGASGCGKSTTVQLLQRFYDPDQGEVTLDGRDIRTLNVKW 542
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR IGIV QEP++F T+AENIR G I+D +IE+A K ANA +FI +L D+++T++G
Sbjct: 543 LRENIGIVSQEPVLFATTIAENIRYGREDISDAEIEQAAKEANAFDFISRLPDKFNTMVG 602
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
QLSGGQKQR+AIARA+ R P+ILLLDEATSALDT+SE +VQ ALDKA GRTT+ I
Sbjct: 603 ERGAQLSGGQKQRIAIARALARNPKILLLDEATSALDTQSESVVQAALDKARTGRTTIVI 662
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
AHRLSTIR A I F++G++ E+GTH EL+ + G+Y S+V Q
Sbjct: 663 AHRLSTIRTADTIAAFEKGIVVEQGTHSELMLQK-GVYYSLVMQQSGSNNVQDDGTSEED 721
Query: 722 XXXXHRSFHRDSVTSDEER-------ELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXX 880
+ + +S E+ E R S R R S +
Sbjct: 722 EETEAEEYEENDKSSSVEKLNLKDHFEEPVITGRGSIRRRSSRYKSKRSSSKKKSSKKKK 781
Query: 881 XXXXXGAMEASLFD-IFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGD 1057
+ A + I PE +++ ++ + G PAF++++G++
Sbjct: 782 KELEEENLPAVPYTRILALNKPEWLYVLLGVIAAAVSGGVHPAFAVIFGKIIGAFQERDP 841
Query: 1058 DVSIK-ALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFD 1234
+ K L+ SL F+LL + +I G + GK+GE ++ RLR F+ ++QQ+ ++D
Sbjct: 842 ERRNKNTLVLSLMFLLLGVITLATYIIQGFMFGKSGEILTMRLRSLSFKALLQQEIGWYD 901
Query: 1235 DSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXX 1414
D ++ VG L +RLATDA V+ A RL + + +L + +AF YGW + +
Sbjct: 902 DQKNAVGVLLTRLATDASQVKGATGSRLGLMTMTVFTLLTAIIIAFVYGWQLTLLILACI 961
Query: 1415 XXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASK 1594
+ +D + EA R+ TES+ N +TV +LT++E Y+ + +
Sbjct: 962 PFVIAANAANVSSVSGHAAKDQKALEEAGRVSTESVENIRTVASLTREEAFYEKYINSLN 1021
Query: 1595 SPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMAS 1774
P+R ++ + ++ +A S + A + FG WLI+ + VF V ++ A+
Sbjct: 1022 GPYRDSLKKAPLYGFTYGIAQSANYFVNAAVFRFGAWLIARCLTNFENVFIVFSSVIFAA 1081
Query: 1775 MSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDT-PTIKGNINMRGVYFAYP 1951
M+V +AS P+Y +A++SA +F ++ +K ID+ G+ +GNI R ++F YP
Sbjct: 1082 MNVGQSASLAPDYGKAKVSAQRIFHLLDRKPQIDSYSEEGEKLSNFEGNIEFRNIHFVYP 1141
Query: 1952 NRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLS 2131
R VL G N+ N GQT+ALVG SGCGKST+IQL+ER+YD + G V D D + L
Sbjct: 1142 TRPEVQVLQGLNVKVNKGQTLALVGSSGCGKSTSIQLLERFYDPVEGQVLADGFDTKSLH 1201
Query: 2132 VKHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGY 2305
++ LR + LV QEP LF+ +I ENI YG N ++Q+++E+AA ANIH F+ LP+ Y
Sbjct: 1202 LQWLRSRLGLVSQEPILFDCSIAENIQYGDNNRLVSQEEIEEAAKAANIHAFIDKLPEKY 1261
Query: 2306 DTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGR 2485
+T VG G +LSGGQKQR+AIARA+VR+P +LLLDEATSALDTESEKIVQ+ALD AR GR
Sbjct: 1262 NTRVGEKGTQLSGGQKQRIAIARALVRNPAVLLLDEATSALDTESEKIVQKALDNARQGR 1321
Query: 2486 TCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRL 2620
TC+VIAHRL+TIQNAD I V +NG+ +E+GTH LLA+ G YY L
Sbjct: 1322 TCIVIAHRLTTIQNADIIAVIQNGRVVEQGTHSQLLAKEGHYYAL 1366
Score = 326 bits (836), Expect = 2e-87
Identities = 197/600 (32%), Positives = 317/600 (52%), Gaps = 26/600 (4%)
Frame = +2
Query: 914 LFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFK--ILSAGGDDVSIKALLN 1084
+ ++F+YA ++ +++ L+ G P I++G + +LS S A +N
Sbjct: 111 VIELFRYADWVDILLMVVGLIAAAANGTGLPLMIIIFGDMTNAFVLSGVNSSTSEGASVN 170
Query: 1085 S-------------------LWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNI 1207
+ +++ + F I + I A + R+R F +
Sbjct: 171 NSSCQPAPGVDIEADMTKFAYYYVGIGFAVLILSTIQVWTFLIAATRQTSRIRRKFFFAV 230
Query: 1208 MQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWN 1387
+ Q+ ++FD ++ +G+L +RL D + I ++ + + G+ + F +GW
Sbjct: 231 LHQEMAWFDSTQ--IGTLNTRLTDDINTIHEGIGDKICIFVQFFSTFLAGITIGFAHGWK 288
Query: 1388 MAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYM 1567
+ + L +++ + +A + E ++ +TV A Q+
Sbjct: 289 LTLVILSVSPLLAASAAVWSTLLASLTAKELSAYAKAGAVAEEVLTAIRTVVAFNGQQKA 348
Query: 1568 YDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLI---SNNWSTPYT 1738
+ ++ + + + + S ++ + ++A+A+ +G L N+
Sbjct: 349 LAKYDTNLEAARHVGVKKSITTNTSLGVSQFLIFGSYALAFWYGTKLTVEEPENYDIGRV 408
Query: 1739 VFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKG 1915
+ L + + S+ AA AR +A ++ +I +K +ID+ G P +KG
Sbjct: 409 LIVFFSVL-IGAFSLGQAAPNLESVANARGAAYEVYQIINKKRLIDSSSKEGYKPDKLKG 467
Query: 1916 NINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGS 2095
I R ++F+YP+R +L G N+ G+T+ALVG SGCGKSTT+QL++R+YD G
Sbjct: 468 EIEFRNIHFSYPSRPDITILKGLNLKVQTGKTIALVGASGCGKSTTVQLLQRFYDPDQGE 527
Query: 2096 VKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIH 2275
V +D DIR L+VK LR+NI +V QEP LF TI ENI YG E+I+ ++E+AA AN
Sbjct: 528 VTLDGRDIRTLNVKWLRENIGIVSQEPVLFATTIAENIRYGREDISDAEIEQAAKEANAF 587
Query: 2276 TFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQ 2455
F+ LPD ++T VG G +LSGGQKQR+AIARA+ R+PKILLLDEATSALDT+SE +VQ
Sbjct: 588 DFISRLPDKFNTMVGERGAQLSGGQKQRIAIARALARNPKILLLDEATSALDTQSESVVQ 647
Query: 2456 EALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
ALDKAR GRT +VIAHRLSTI+ AD I G +E+GTH L+ ++G+YY LV +QS
Sbjct: 648 AALDKARTGRTTIVIAHRLSTIRTADTIAAFEKGIVVEQGTHSELMLQKGVYYSLVMQQS 707
>gi|6679297|ref|NP_032856.1| ATP-binding cassette, sub-family B
(MDR/TAP), member 4; P glycoprotein 2 [Mus musculus]
gi|126929|sp|P21440|MDR2_MOUSE Multidrug resistance protein 2
(P-glycoprotein 2)
gi|72476|pir||DVMS2 multidrug resistance protein 2 - mouse
gi|387428|gb|AAA39516.1| multidrug resistance protein
Length = 1276
Score = 659 bits (1699), Expect = 0.0
Identities = 368/881 (41%), Positives = 530/881 (59%), Gaps = 4/881 (0%)
Frame = +2
Query: 5 LKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWL 184
+KILKG++ +V G+TVALVG+SGCGKST++ LL R Y+ G I +DG I+ +N+R L
Sbjct: 406 IKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGKISIDGQDIRNFNVRCL 465
Query: 185 RSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIGA 364
R IG+V QEP++F T+AENIR G +T +IE+A K ANA++FI KL ++DT++G
Sbjct: 466 REIIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIEKAVKEANAYDFIMKLPQKFDTLVGD 525
Query: 365 GAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIA 544
QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE VQ ALDKA EGRTT+ IA
Sbjct: 526 RGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIA 585
Query: 545 HRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXXX 724
HRLSTIRNA I F+ G+I E+G+H EL+ K+ GIY +V Q
Sbjct: 586 HRLSTIRNADVIAGFEDGVIVEQGSHSELMKKE-GIYFRLVNMQ--------------TA 630
Query: 725 XXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXXXXGAM 904
S + SDE+ + R+ ++ + + P
Sbjct: 631 GSQILSEEFEVELSDEKAAGDVAPNGWKARIFRNSTKKSLKSPHQNRLDEETNELDANVP 690
Query: 905 EASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSI-KALL 1081
S + K E ++ V + G PAFSI+ ++ I G D V K +
Sbjct: 691 PVSFLKVLKLNKTEWPYFVVGTVCAIANGALQPAFSIILSEMIAIFGPGDDAVKQQKCNM 750
Query: 1082 NSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSL 1261
SL F+ L + + G GKAGE ++ RLR F+ +++QD S+FDD +++ G+L
Sbjct: 751 FSLVFLGLGVLSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDHKNSTGAL 810
Query: 1262 TSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXXX 1441
++RLATDA VQ A +LA + +L G+ ++F YGW + +
Sbjct: 811 STRLATDAAQVQGATGTKLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVAGIV 870
Query: 1442 XXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVR 1621
L +RD A ++ TE+I N +TV +LT++ + P+R ++ +
Sbjct: 871 EMKMLAGNAKRDKKEMEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLHGPYRNSVRK 930
Query: 1622 GLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAASY 1801
++F+++ +F+ +++A + FG +LI N V V A+ + ++++ A+S+
Sbjct: 931 AHIYGITFSISQAFMYFSYAGCFRFGSYLIVNGHMRFKDVILVFSAIVLGAVALGHASSF 990
Query: 1802 FPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFAYPNRRRQLVLD 1978
P+Y +A++SA +F++ ++ +ID+ G P +G++ V F YP R VL
Sbjct: 991 APDYAKAKLSAAYLFSLFERQPLIDSYSGEGLWPDKFEGSVTFNEVVFNYPTRANVPVLQ 1050
Query: 1979 GFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIA 2158
G ++ GQT+ALVG SGCGKST +QL+ER+YD + GSV +D + + L+V+ LR +
Sbjct: 1051 GLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVLLDGQEAKKLNVQWLRAQLG 1110
Query: 2159 LVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGG 2332
+V QEP LF+ +I ENI YG + + D++ +AA ANIH F+ LP Y+T VG G
Sbjct: 1111 IVSQEPILFDCSIAENIAYGDNSRVVPHDEIVRAAKEANIHPFIETLPQKYNTRVGDKGT 1170
Query: 2333 RLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRL 2512
+LSGGQKQR+AIARA++R P++LLLDEATSALDTESEK+VQEALDKAR GRTC+VIAHRL
Sbjct: 1171 QLSGGQKQRIAIARALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRL 1230
Query: 2513 STIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
STIQNAD I+V NGK E GTHQ LLA++G+Y+ +V Q+
Sbjct: 1231 STIQNADLIVVIENGKVKEHGTHQQLLAQKGIYFSMVNIQA 1271
Score = 329 bits (844), Expect = 2e-88
Identities = 188/488 (38%), Positives = 275/488 (55%), Gaps = 1/488 (0%)
Frame = +2
Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
++R F I++Q+ +FD L +RL D + I ++ I + F G
Sbjct: 145 KIRQKFFHAILRQEMGWFDIK--GTTELNTRLTDDVSKISEGIGDKVGMFFQAIATFFAG 202
Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
V F GW + + L +++ + +A + E+ +T
Sbjct: 203 FIVGFIRGWKLTLVIMAISPILGLSTAVWAKILSTFSDKELAAYAKAGAVAEEAPGAIRT 262
Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
V A Q + + ++ + I + + ++S +A + ++A+A+ +G L+ +
Sbjct: 263 VIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVIS 322
Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
T V ++ + + SV AA + AR +A ++F +I ID+ G
Sbjct: 323 KEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGH 382
Query: 1898 TP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
P IKGN+ V+F+YP+R +L G N+ GQTVALVG SGCGKSTT+QL++R
Sbjct: 383 KPDNIKGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRL 442
Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
YD G + ID DIR+ +V+ LR+ I +V QEP LF+ TI ENI YG N+T D++EKA
Sbjct: 443 YDPTEGKISIDGQDIRNFNVRCLREIIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIEKA 502
Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
AN + F+M LP +DT VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDT
Sbjct: 503 VKEANAYDFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 562
Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
ESE VQ ALDKAR GRT +VIAHRLSTI+NAD I +G +E+G+H L+ + G+Y+
Sbjct: 563 ESEAEVQAALDKAREGRTTIVIAHRLSTIRNADVIAGFEDGVIVEQGSHSELMKKEGIYF 622
Query: 2615 RLVEKQSS 2638
RLV Q++
Sbjct: 623 RLVNMQTA 630
>gi|4505771|ref|NP_000434.1| ATP-binding cassette, subfamily B, member
4 isoform A; P glycoprotein 3/multiple drug resistance 3;
P-glycoprotein-3/multiple drug resistance-3; multiple
drug resistance 3 [Homo sapiens]
gi|126932|sp|P21439|MDR3_HUMAN Multidrug resistance protein 3
(P-glycoprotein 3)
gi|72473|pir||DVHU3 multidrug resistance protein 3 - human
gi|307181|gb|AAA36207.1| P-glycoprotein
Length = 1279
Score = 658 bits (1698), Expect = 0.0
Identities = 366/883 (41%), Positives = 533/883 (59%), Gaps = 6/883 (0%)
Frame = +2
Query: 5 LKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWL 184
+KILKG++ +V G+TVALVG SGCGKST++ L+ R Y+ G I +DG I+ +N+ +L
Sbjct: 409 VKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYL 468
Query: 185 RSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIGA 364
R IG+V QEP++F T+AENI G +T +I++A K ANA+EFI KL ++DT++G
Sbjct: 469 REIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGE 528
Query: 365 GAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIA 544
QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE VQ ALDKA EGRTT+ IA
Sbjct: 529 RGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIA 588
Query: 545 HRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXXX 724
HRLST+RNA I F+ G+I E+G+H EL+ K+ G+Y +V Q
Sbjct: 589 HRLSTVRNADVIAGFEDGVIVEQGSHSELMKKE-GVYFKLVNMQ----TSGSQIQSEEFE 643
Query: 725 XXXHRSFHRDSVTSDEERELQQSLARD--STRLRQSMISTTTQVPXXXXXXXXXXXXXXG 898
++ R + + R + S ++ ++++ Q + T
Sbjct: 644 LNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETD------------GLEAN 691
Query: 899 AMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSI-KA 1075
S + K E ++ V + G PAFS+++ ++ I G D V K
Sbjct: 692 VPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKC 751
Query: 1076 LLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVG 1255
+ SL F+ L + + G GKAGE ++ RLR F+ +++QD S+FDD +++ G
Sbjct: 752 NIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTG 811
Query: 1256 SLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXX 1435
+L++RLATDA VQ A RLA + I +L G+ ++F YGW + +
Sbjct: 812 ALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSG 871
Query: 1436 XXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAI 1615
L +RD A ++ TE+I N +TV +LT++ + P+R ++
Sbjct: 872 IVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSV 931
Query: 1616 VRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAA 1795
+ ++F+++ +F+ +++A + FG +LI N V V A+ ++++ A+
Sbjct: 932 QKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHAS 991
Query: 1796 SYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFAYPNRRRQLV 1972
S+ P+Y +A++SA +F + ++ +ID+ G P +GNI V F YP R V
Sbjct: 992 SFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPV 1051
Query: 1973 LDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDN 2152
L G ++ GQT+ALVG SGCGKST +QL+ER+YD L G+V +D + + L+V+ LR
Sbjct: 1052 LQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQ 1111
Query: 2153 IALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYDTSVGAS 2326
+ +V QEP LF+ +I ENI YG + ++QD++ AA ANIH F+ LP Y+T VG
Sbjct: 1112 LGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDK 1171
Query: 2327 GGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAH 2506
G +LSGGQKQR+AIARA++R P+ILLLDEATSALDTESEK+VQEALDKAR GRTC+VIAH
Sbjct: 1172 GTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAH 1231
Query: 2507 RLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
RLSTIQNAD I+V +NG+ E GTHQ LLA++G+Y+ +V Q+
Sbjct: 1232 RLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1274
Score = 331 bits (849), Expect = 5e-89
Identities = 186/488 (38%), Positives = 279/488 (57%), Gaps = 1/488 (0%)
Frame = +2
Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
++R F I++Q+ +FD + + L +RL D + I ++ + + F G
Sbjct: 148 KIRQKFFHAILRQEIGWFDIN--DTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAG 205
Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
V F GW + + L +++ + +A + E++ +T
Sbjct: 206 FIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRT 265
Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
V A Q + + ++ I + + ++S +A + ++A+A+ +G L+ +
Sbjct: 266 VIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVIS 325
Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
T V ++ + + SV AA + AR +A ++F +I ID+ G
Sbjct: 326 KEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGH 385
Query: 1898 TP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
P +IKGN+ V+F+YP+R +L G N+ GQTVALVG SGCGKSTT+QLI+R
Sbjct: 386 KPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRL 445
Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
YD G++ ID DIR+ +V +LR+ I +V QEP LF+ TI ENI YG N+T D+++KA
Sbjct: 446 YDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKA 505
Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
AN + F+M LP +DT VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDT
Sbjct: 506 VKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 565
Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
ESE VQ ALDKAR GRT +VIAHRLST++NAD I +G +E+G+H L+ + G+Y+
Sbjct: 566 ESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYF 625
Query: 2615 RLVEKQSS 2638
+LV Q+S
Sbjct: 626 KLVNMQTS 633
>gi|6981354|ref|NP_036822.1| ATP-binding cassette, sub-family B
(MDR/TAP), member 4; ATP-binding cassette, sub-family B
(MDR/TAP), member 4 (P-glycoprotein 3/ multidrug
resistance 2); ATP-binding cassette sub-family B
(MDR/TAP) member 4 (P-glycoprotein 3/ multidrug
resistance 2); P-glycoprotein 3/ multidrug resistance 2;
ATP-binding cassette sub-family B (MDR/TAP) member 4
(P-glycoprotein 3/ multidrug resistance 2 [Rattus
norvegicus]
gi|1170903|sp|Q08201|MDR2_RAT Multidrug resistance protein 2
(P-glycoprotein 2)
gi|543425|pir||S41646 p-glycoprotein - rat
gi|310193|gb|AAA02937.1| P-glycoprotein
Length = 1278
Score = 656 bits (1693), Expect = 0.0
Identities = 370/892 (41%), Positives = 536/892 (59%), Gaps = 15/892 (1%)
Frame = +2
Query: 5 LKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWL 184
+KILKG++ +V G+TVALVG+SGCGKST++ LL R Y+ G I +DG I+ +N+R L
Sbjct: 406 IKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGTISIDGQDIRNFNVRCL 465
Query: 185 RSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIGA 364
R IG+V QEP++F T+AENIR G +T +I++A K ANA++FI KL ++DT++G
Sbjct: 466 REFIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIKKAVKEANAYDFIMKLPQKFDTLVGD 525
Query: 365 GAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIA 544
QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE VQ ALDKA EGRTT+ IA
Sbjct: 526 RGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIA 585
Query: 545 HRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ-----------EIERA 691
HRLST+RNA I F+ G+I E+G+H ELI K+ GIY +V Q E+E +
Sbjct: 586 HRLSTVRNADVIAGFEDGVIVEQGSHSELIKKE-GIYFRLVNMQTSGSQILSEEFEVELS 644
Query: 692 XXXXXXXXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXX 871
R F + ++ L+ S A + RL VP
Sbjct: 645 DEKAAGGVAPNGWKARIFRNST-----KKSLKSSRAHQN-RLDVETNELDANVP------ 692
Query: 872 XXXXXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAG 1051
S + + E ++ + + G PAFSI+ ++ I G
Sbjct: 693 -----------PVSFLKVLRLNKTEWPYFVVGTLCAIANGALQPAFSIILSEMIAIFGPG 741
Query: 1052 GDDVSI-KALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASY 1228
D V K + SL F+ L + + G GKAGE ++ RLR F+ +++QD S+
Sbjct: 742 DDTVKQQKCNMFSLVFLGLGVHSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSW 801
Query: 1229 FDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXX 1408
FDD +++ G+L++RLATDA VQ A RLA + +L G+ ++F YGW + +
Sbjct: 802 FDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNTANLGTGIIISFIYGWQLTLLLLS 861
Query: 1409 XXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAA 1588
L +RD A ++ TE+I N +TV +LT++ +
Sbjct: 862 VVPFIAVAGIVEMKMLAGNAKRDKKEMEAAGKIATEAIENIRTVVSLTQERKFESMYVEK 921
Query: 1589 SKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNM 1768
P+R ++ + ++F+++ +F+ +++A + FG +LI N V V A+ +
Sbjct: 922 LHGPYRNSVRKAHIYGITFSISQAFMYFSYAGCFRFGSYLIVNGHMRFKDVILVFSAIVL 981
Query: 1769 ASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFA 1945
++++ A+S+ P+Y +A++SA +F++ ++ +ID+ G P +G++ V F
Sbjct: 982 GAVALGHASSFAPDYAKAKLSAAYLFSLFERQPLIDSYSREGMWPDKFEGSVTFNEVVFN 1041
Query: 1946 YPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRD 2125
YP R VL G ++ GQT+ALVG SGCGKST +QL+ER+YD + G+V +D + +
Sbjct: 1042 YPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVLLDGQEAKK 1101
Query: 2126 LSVKHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPD 2299
L+V+ LR + +V QEP LF+ +I +NI YG + ++QD++ +AA ANIH F+ LP
Sbjct: 1102 LNVQWLRAQLGIVSQEPILFDCSIAKNIAYGDNSRVVSQDEIVRAAKEANIHPFIETLPQ 1161
Query: 2300 GYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARL 2479
Y+T VG G +LSGGQKQR+AIARA++R P++LLLDEATSALDTESEK+VQEALDKAR
Sbjct: 1162 KYETRVGDKGTQLSGGQKQRIAIARALIRQPRVLLLDEATSALDTESEKVVQEALDKARE 1221
Query: 2480 GRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
GRTC+VIAHRLSTIQNAD I+V NGK E GTHQ LLA++G+Y+ +V Q+
Sbjct: 1222 GRTCIVIAHRLSTIQNADLIVVIDNGKVKEHGTHQQLLAQKGIYFSMVNIQA 1273
Score = 331 bits (848), Expect = 6e-89
Identities = 187/488 (38%), Positives = 278/488 (56%), Gaps = 1/488 (0%)
Frame = +2
Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
++R F I++Q+ +FD L +RL D + I ++ I + F G
Sbjct: 145 KIRQKFFHAILRQEMGWFDIK--GTTELNTRLTDDISKISEGIGDKVGMFFQAIATFFAG 202
Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
V F GW + + L +++ + +A + E++ +T
Sbjct: 203 FIVGFIRGWKLTLVIMAITAILGLSTAVWAKILSTFSDKELAAYAKAGAVAEEALGAIRT 262
Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
V A Q + + ++ + I + + ++S +A + ++A+A+ +G L+ +
Sbjct: 263 VIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVIS 322
Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
T V ++ + + SV AA + AR +A ++F +I ID+ G
Sbjct: 323 KEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFPNARGAAYVIFDIIDNNPKIDSFSERGH 382
Query: 1898 TP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
P +IKGN+ V+F+YP+R +L G N+ GQTVALVG SGCGKSTT+QL++R
Sbjct: 383 KPDSIKGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRL 442
Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
YD G++ ID DIR+ +V+ LR+ I +V QEP LF+ TI ENI YG N+T D+++KA
Sbjct: 443 YDPTEGTISIDGQDIRNFNVRCLREFIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIKKA 502
Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
AN + F+M LP +DT VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDT
Sbjct: 503 VKEANAYDFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 562
Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
ESE VQ ALDKAR GRT +VIAHRLST++NAD I +G +E+G+H L+ + G+Y+
Sbjct: 563 ESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELIKKEGIYF 622
Query: 2615 RLVEKQSS 2638
RLV Q+S
Sbjct: 623 RLVNMQTS 630
>gi|1170902|sp|P43245|MDR1_RAT Multidrug resistance protein 1
(P-glycoprotein 1)
gi|92489|pir||JH0502 p-glycoprotein - rat
Length = 1277
Score = 655 bits (1690), Expect = 0.0
Identities = 372/888 (41%), Positives = 542/888 (60%), Gaps = 13/888 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
E+KILKG++ +V G+TVALVG+SGCGKST++ LL R Y+ G + +DG I+ N+R+
Sbjct: 405 EVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIRTINVRY 464
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR IG+V QEP++F T+AENIR G +T +IE+A K ANA++FI KL ++DT++G
Sbjct: 465 LREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVG 524
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA EGRTT+ I
Sbjct: 525 ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVI 584
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ----EIERAXXXXXX 709
AHRLST+RNA I FD G+I E+G H+EL+ K+ GIY +V Q EIE
Sbjct: 585 AHRLSTVRNADVIAGFDGGVIVEQGNHEELM-KEKGIYFKLVMTQTRGNEIEPGNNAYES 643
Query: 710 XXXXXXXXHRSFHRDSVTSDEERELQQSLAR--DSTRLRQSMISTTTQVPXXXXXXXXXX 883
S +S + R +++S+ R D R S VP
Sbjct: 644 QSDTGASELTS--EESKSPLIRRSIRRSIHRRQDQERRLSSKEDVDEDVPM--------- 692
Query: 884 XXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV 1063
S + I K E +++ ++ +I G P F+IV+ ++ + S D
Sbjct: 693 --------VSFWQILKLNISEWPYLVVGVLCAVINGCIQPVFAIVFSKIVGVFSRDDDHE 744
Query: 1064 SIKALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDD 1237
+ + N SL F+++ ++ G GKAGE ++ RLR VF+++++QD S+FDD
Sbjct: 745 TKQRNCNLFSLLFLVMGMISFVTYFFQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDD 804
Query: 1238 SRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGV--GVAFYYGWNMAPIGXXX 1411
++ GSLT+RLA+DA NV+ A+ RLA V + +L G+ + YGW + +
Sbjct: 805 HKNTTGSLTTRLASDASNVKGAMGSRLAVVTQNVANLGTGIILSLVLVYGWQLTLLLVVI 864
Query: 1412 XXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAAS 1591
L + +D + ++ TE+I N++TV +LT+++ + +
Sbjct: 865 IPLIVLGGIIEMKLLSGQALKDKKELEISGKIATEAIENFRTVVSLTREQKFETMYAQSL 924
Query: 1592 KSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMA 1771
+ P+R A+ + ++FA + + +++A + FG +L++ T V V A+
Sbjct: 925 QIPYRNALKKAHVFGITFAFTQAMIYFSYAACFRFGAYLVARELMTFENVMLVFSAVVFG 984
Query: 1772 SMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFAY 1948
+M+ +S+ P+Y +A++SA + +I + ID+ G P ++GN+ GV F Y
Sbjct: 985 AMAAGNTSSFAPDYAKAKVSASHIIGIIEKIPEIDSYSTEGLKPNWLEGNVKFNGVKFNY 1044
Query: 1949 PNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDL 2128
P R VL G + GQT+ LVG SGCGKST +QL+ER+Y+ + G+V +D +I+ L
Sbjct: 1045 PTRPNIPVLQGLSFEVKKGQTLRLVGSSGCGKSTVVQLLERFYNPMAGTVFLDGKEIKQL 1104
Query: 2129 SVKHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDG 2302
+V+ +R + +V QEP LF+ +I ENI YG + ++ +++ +AA ANIH F+ LP+
Sbjct: 1105 NVQCVR-ALGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIVRAAREANIHQFIDSLPEK 1163
Query: 2303 YDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLG 2482
Y+T VG G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR G
Sbjct: 1164 YNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREG 1223
Query: 2483 RTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVE 2626
RTCVVIAHRLSTIQNAD I+V +NG+ E GTHQ LLA++G+Y+ +V+
Sbjct: 1224 RTCVVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMVQ 1271
Score = 340 bits (872), Expect = 1e-91
Identities = 211/598 (35%), Positives = 316/598 (52%), Gaps = 24/598 (4%)
Frame = +2
Query: 914 LFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALLNS- 1087
+F +F+YA + + + + +I G P +V+G + + D S +A+ N
Sbjct: 34 IFGMFRYADWLDKLCMALGTLAAIIHGTLLPLLMLVFGYMTDSFTPSRDPHSDRAITNQS 93
Query: 1088 ----------------LWFILLAFTG-GISTLISG----SLLGKAGETMSGRLRMDVFRN 1204
+ +TG G LI SL A ++R F
Sbjct: 94 EINSTHTVSDTSLEEDMAMYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHA 153
Query: 1205 IMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGW 1384
IM Q+ +FD + + G L +RL D + I +L I + G + F GW
Sbjct: 154 IMNQEIGWFDVN--DAGELNTRLTDDVSKINDGIGDKLGMFFQSITTFSAGFIIGFISGW 211
Query: 1385 NMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEY 1564
+ + L +++ + +A + E ++ +TV A Q+
Sbjct: 212 KLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQKK 271
Query: 1565 MYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVF 1744
+ + + R I + + ++S +A V ++A+A+ +G L+ +N + V
Sbjct: 272 ELERYNKNLEEAKRVGIKKAITANISIGIAYLLVYASYALAFWYGTSLVLSNEYSIGQVL 331
Query: 1745 QVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNI 1921
V ++ + + S+ A + AR +A +F +I + ID+ G P +I GN+
Sbjct: 332 TVFFSILLGTFSIGHLAPNIEAFANARGAAYEIFKIIDNEPSIDSFSTKGHKPDSIMGNL 391
Query: 1922 NMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVK 2101
+ VYF YP+R +L G N+ GQTVALVG SGCGKSTT+QL++R YD + G V
Sbjct: 392 EFKNVYFNYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVS 451
Query: 2102 IDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTF 2281
ID DIR ++V++LR+ I +V QEP LF TI ENI YG EN+T D++EKA AN + F
Sbjct: 452 IDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDF 511
Query: 2282 VMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEA 2461
+M LP +DT VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +VQ A
Sbjct: 512 IMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAA 571
Query: 2462 LDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
LDKAR GRT +VIAHRLST++NAD I G +E+G H+ L+ +G+Y++LV Q+
Sbjct: 572 LDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIYFKLVMTQT 629
>gi|40644181|emb|CAC86600.1| multidrug resistance protein [Platichthys
flesus]
Length = 1292
Score = 653 bits (1685), Expect = 0.0
Identities = 364/888 (40%), Positives = 533/888 (59%), Gaps = 11/888 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
+++ILK +S V G+T+ALVG SGCGKST++ LL RFY+ G + +DG I+ N+R+
Sbjct: 416 DVQILKNMSLSVKSGQTMALVGSSGCGKSTTVQLLQRFYDPQDGAVFVDGHDIRSLNVRY 475
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR IG+V QEPI+F T++ENIR G + +TDQ+IE+A K ANA++FI KL D+++T++G
Sbjct: 476 LREMIGVVSQEPILFATTISENIRYGRLDVTDQEIEQAAKEANAYDFIIKLPDKFETLVG 535
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
Q+SGGQKQRVAIARA+VR P+ILLLDEATSALD ESE +VQ ALDK GRTT+ +
Sbjct: 536 DRGTQMSGGQKQRVAIARALVRNPKILLLDEATSALDAESETIVQAALDKVRLGRTTIVV 595
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKA---QEIERAXXXXXXX 712
AHRLSTIRNA I F G +AE GTH +L+ K GIY +V Q++E A
Sbjct: 596 AHRLSTIRNADVIAGFQDGQVAEVGTHSQLMEK-KGIYQRLVTTQTFQDVEEAKEA---- 650
Query: 713 XXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQ----SMISTTTQVPXXXXXXXXX 880
+ ++ DE+ L SL+ + R+ S +S +
Sbjct: 651 ------------EEELSVDEKSPLADSLSECTPYRRKTTRGSSMSASEGGKEKTESDKDE 698
Query: 881 XXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDD 1060
S + + PE +++ V +I G P F+I++ ++ + + +
Sbjct: 699 TEEDENVPPVSFLKVLRLNLPEWPYMLVGTVCAIINGAMQPVFAIIFSKIITVFAEKDQE 758
Query: 1061 -VSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDD 1237
V +A L SL F ++ ++ + G GK+GE ++ +LR+ F+ +M+QD S+FD+
Sbjct: 759 LVRQRATLFSLMFAVIGGVSFVTMFLQGFCFGKSGEILTLKLRLGAFKAMMRQDLSWFDN 818
Query: 1238 SRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXX 1417
+++VG+LT+RLATDA VQ A R+A + +L V ++F YGW + +
Sbjct: 819 PKNSVGALTTRLATDAAQVQGATGVRMATLAQNFANLGTSVIISFIYGWELTLLILAVVP 878
Query: 1418 XXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKS 1597
L D +A ++ TE+I N +TV +LT++ + +
Sbjct: 879 AMVLAGAVEMKLLTGHAVEDKKELEKAGKISTEAIENIRTVASLTREPKFESLYHKNLEV 938
Query: 1598 PHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASM 1777
P++ + + +FA + + + + +A + FG WLI VF VI A+ +M
Sbjct: 939 PYKNSTKKAHVYGATFAFSQAMIYFAYAGCFRFGAWLIEEGRMDVQGVFLVISAVLYGAM 998
Query: 1778 SVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYPN 1954
++ A S+ P Y +A++SA + ++ + IDN G+TP GN++ V F YP+
Sbjct: 999 AIGEANSFAPNYAKAKMSASHLMMLMNLEPAIDNLSQEGETPDRFDGNVHFENVRFNYPS 1058
Query: 1955 RRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSV 2134
R VL G ++ G+T+ALVG SGCGKST IQL+ER+YD GSV +D+ + + L++
Sbjct: 1059 RPNLPVLQGLDLEVKRGETLALVGSSGCGKSTIIQLLERFYDPREGSVVLDNVNTKQLNI 1118
Query: 2135 KHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYD 2308
LR + +V QEPTLF+ T+ +NI YG + T D++ AA ANIH+F+ LP+ YD
Sbjct: 1119 HWLRSQMGIVSQEPTLFDCTLAQNIAYGDNSRIATMDEIVAAAKAANIHSFIQELPEKYD 1178
Query: 2309 TSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRT 2488
T G G +LSGGQKQR+AIARAI+R+P +LLLDEATSALDTESEK+VQEALD+A GRT
Sbjct: 1179 TQAGDKGTQLSGGQKQRIAIARAILRNPMLLLLDEATSALDTESEKVVQEALDQASKGRT 1238
Query: 2489 CVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
C+++AHRLSTIQNAD+I V + G +E+GTHQ LLA+RG+Y+ LV Q
Sbjct: 1239 CIIVAHRLSTIQNADRIAVLQGGVVVEQGTHQQLLAKRGVYHMLVTTQ 1286
Score = 332 bits (851), Expect = 3e-89
Identities = 203/595 (34%), Positives = 321/595 (53%), Gaps = 23/595 (3%)
Frame = +2
Query: 920 DIFKYA-SPEMRNIIISLVFTLIRGFTWPAFSIVYGQL---------------FKILSAG 1051
D+F++A S ++ I+ V + G P IV+G + F ++
Sbjct: 48 DVFRFADSLDIFMILCGTVMAMANGVVLPLMCIVFGDMTDSLVNFPTGEISDNFTVIYPN 107
Query: 1052 GDDVSIKALLN------SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQ 1213
+ I + L ++++ ++ T ++ + SL A R+R F IMQ
Sbjct: 108 FTGLPINSTLQEDMNRYAIYYSIMGATVLVAAYLQVSLWTMAAGRQVKRIRKLFFHRIMQ 167
Query: 1214 QDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMA 1393
QD +FD + G L +RL D +Q I + A ++ + + F GW +
Sbjct: 168 QDIGWFDVNE--TGELNTRLIDDVYKIQEGIGDKAAMLIQAYTTFLSAFVIGFTKGWKLT 225
Query: 1394 PIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYD 1573
+ L ++ + +A + E ++ +TV A + Q+
Sbjct: 226 LVILAVSPALGLSAALFSKVLTSFTSKEQAAYAKAGAVAEEVLAAIRTVFAFSGQDREIK 285
Query: 1574 AFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVI 1753
+ + I + L ++S + ++A+A+ +G LI +N T +V V+
Sbjct: 286 RYHKNLEDAKIMGIKKALSANISMGFTFMVIYLSYALAFWYGSTLILSNEYTIGSVLTVL 345
Query: 1754 EALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMR 1930
+ + + ++ +++ + AR +A ++++I ID+ G P +IKGNI +
Sbjct: 346 FVVLIGAFTMGQSSANIQTFASARGAAHKVYSIIDNNPTIDSYSEAGFKPDSIKGNIEFK 405
Query: 1931 GVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDD 2110
++F+YP R +L ++S GQT+ALVG SGCGKSTT+QL++R+YD G+V +D
Sbjct: 406 NIHFSYPTRPDVQILKNMSLSVKSGQTMALVGSSGCGKSTTVQLLQRFYDPQDGAVFVDG 465
Query: 2111 SDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMG 2290
DIR L+V++LR+ I +V QEP LF TI ENI YG ++T ++E+AA AN + F++
Sbjct: 466 HDIRSLNVRYLREMIGVVSQEPILFATTISENIRYGRLDVTDQEIEQAAKEANAYDFIIK 525
Query: 2291 LPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDK 2470
LPD ++T VG G ++SGGQKQRVAIARA+VR+PKILLLDEATSALD ESE IVQ ALDK
Sbjct: 526 LPDKFETLVGDRGTQMSGGQKQRVAIARALVRNPKILLLDEATSALDAESETIVQAALDK 585
Query: 2471 ARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
RLGRT +V+AHRLSTI+NAD I ++G+ E GTH L+ ++G+Y RLV Q+
Sbjct: 586 VRLGRTTIVVAHRLSTIRNADVIAGFQDGQVAEVGTHSQLMEKKGIYQRLVTTQT 640
>gi|126930|sp|P23174|MDR3_CRIGR Multidrug resistance protein 3
(P-glycoprotein 3)
gi|2119778|pir||I48123 p-glycoprotein isoform III - Chinese hamster
gi|191169|gb|AAA68885.1| p-glycoprotein isoform III
Length = 1281
Score = 653 bits (1684), Expect = 0.0
Identities = 367/892 (41%), Positives = 533/892 (59%), Gaps = 15/892 (1%)
Frame = +2
Query: 5 LKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWL 184
+KILKG++ +V G+TVALVG+SGCGK+T++ LL R Y+ G I +DG I+ +N+R+L
Sbjct: 409 IKILKGLNLKVQSGQTVALVGNSGCGKTTTLQLLQRLYDPTEGTISIDGQDIRNFNVRYL 468
Query: 185 RSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIGA 364
R IG+V QEP++F T+AENIR G +T ++I++A K ANA+EFI KL ++DT++G
Sbjct: 469 REIIGVVSQEPVLFSTTIAENIRYGRGNVTMEEIKKAVKEANAYEFIMKLPQKFDTLVGE 528
Query: 365 GAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIA 544
QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE VQ ALDKA EGRTT+ IA
Sbjct: 529 RGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIA 588
Query: 545 HRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ-----------EIERA 691
HRLST+RNA I F+ G+I E+G+H EL+ K+ G+Y +V Q E+E +
Sbjct: 589 HRLSTVRNADVIAGFEDGVIVEQGSHSELMQKE-GVYFKLVNMQTSGSQILSQEFEVELS 647
Query: 692 XXXXXXXXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXX 871
F + ++ L+ S A RL VP
Sbjct: 648 EEKAADGMTPNGWKSHIFRNST-----KKSLKSSRAHHH-RLDVDADELDANVP------ 695
Query: 872 XXXXXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAG 1051
S + K E ++ V ++ G PA SI+ ++ I G
Sbjct: 696 -----------PVSFLKVLKLNKTEWPYFVVGTVCAIVNGALQPAISIILSEMIAIFGPG 744
Query: 1052 GDDVSI-KALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASY 1228
D V K L SL F+ L + + G GKAGE ++ RLR F+ +++QD S+
Sbjct: 745 DDAVKQQKCNLFSLVFLGLGVLSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSW 804
Query: 1229 FDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXX 1408
FDD +++ G+L++RLATD VQ A RLA + +L G+ ++F YGW + +
Sbjct: 805 FDDYKNSTGALSTRLATDRAQVQGATGTRLALIAQNTANLGTGIIISFIYGWQLTLLLLS 864
Query: 1409 XXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAA 1588
L +RD + A ++ TE+I N +TV +LT++ +
Sbjct: 865 VVPFIAVSGIVEMKMLAGNAKRDKKALEAAGKIATEAIENIRTVVSLTQERKFESMYVEK 924
Query: 1589 SKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNM 1768
P+R ++ ++F+++ +F+ +++A + FG +LI N V V A+
Sbjct: 925 LHEPYRNSVQMAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVF 984
Query: 1769 ASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFA 1945
++++ A+S+ P+Y +A++SA +F++ ++ +ID+ G P +G++ V F
Sbjct: 985 GAVALGHASSFAPDYAKAKLSAAHLFSLFERQPLIDSYSGEGLWPDKFEGSVTFNEVVFN 1044
Query: 1946 YPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRD 2125
YP R VL G ++ GQT+ALVG SGCGKST +QL+ER+YD + G+V +D + +
Sbjct: 1045 YPTRANMPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVLLDGQEAKK 1104
Query: 2126 LSVKHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPD 2299
L+++ LR + +V QEP LF+ +I ENI YG + ++QD++ +AA ANIH F+ LP
Sbjct: 1105 LNIQWLRAQLGIVSQEPVLFDCSIAENIAYGDNSRVVSQDEIVRAAKAANIHPFIETLPQ 1164
Query: 2300 GYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARL 2479
Y T VG G +LSGGQKQR+AI RA++R P++LLLDEATSALDTESEK+VQEALDKAR
Sbjct: 1165 KYKTRVGDKGTQLSGGQKQRLAIRRALIRQPRVLLLDEATSALDTESEKVVQEALDKARE 1224
Query: 2480 GRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
GRTC+VIAHRLSTIQNAD I+V +NGK E GTHQ LLA++G+Y+ +V Q+
Sbjct: 1225 GRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVNIQA 1276
Score = 329 bits (844), Expect = 2e-88
Identities = 183/488 (37%), Positives = 281/488 (57%), Gaps = 1/488 (0%)
Frame = +2
Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
++R + F I++Q+ +FD L +RL D + I ++ + + F G
Sbjct: 148 KIRQNFFHAILRQEMGWFDIK--GTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAG 205
Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
V F GW + + L +++ + +A + E++ +T
Sbjct: 206 FIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSTFSDKELAAYAKAGAVAEEALGAIRT 265
Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
V A Q + + ++ + I + + ++S +A + ++A+A+ +G L+ +
Sbjct: 266 VIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVIS 325
Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
T V ++ + + SV AA + AR +A ++F +I ID+ G
Sbjct: 326 KEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGH 385
Query: 1898 TP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
P +IKGN++ V+F+YP+R +L G N+ GQTVALVG SGCGK+TT+QL++R
Sbjct: 386 KPDSIKGNLDFSDVHFSYPSRANIKILKGLNLKVQSGQTVALVGNSGCGKTTTLQLLQRL 445
Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
YD G++ ID DIR+ +V++LR+ I +V QEP LF+ TI ENI YG N+T ++++KA
Sbjct: 446 YDPTEGTISIDGQDIRNFNVRYLREIIGVVSQEPVLFSTTIAENIRYGRGNVTMEEIKKA 505
Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
AN + F+M LP +DT VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDT
Sbjct: 506 VKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 565
Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
ESE VQ ALDKAR GRT +VIAHRLST++NAD I +G +E+G+H L+ + G+Y+
Sbjct: 566 ESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMQKEGVYF 625
Query: 2615 RLVEKQSS 2638
+LV Q+S
Sbjct: 626 KLVNMQTS 633
>gi|9961250|ref|NP_061337.1| ATP-binding cassette, subfamily B, member
4 isoform B; P glycoprotein 3/multiple drug resistance 3;
P-glycoprotein-3/multiple drug resistance-3; multiple
drug resistance 3 [Homo sapiens]
Length = 1286
Score = 651 bits (1680), Expect = 0.0
Identities = 366/890 (41%), Positives = 533/890 (59%), Gaps = 13/890 (1%)
Frame = +2
Query: 5 LKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWL 184
+KILKG++ +V G+TVALVG SGCGKST++ L+ R Y+ G I +DG I+ +N+ +L
Sbjct: 409 VKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYL 468
Query: 185 RSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIGA 364
R IG+V QEP++F T+AENI G +T +I++A K ANA+EFI KL ++DT++G
Sbjct: 469 REIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGE 528
Query: 365 GAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIA 544
QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE VQ ALDKA EGRTT+ IA
Sbjct: 529 RGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIA 588
Query: 545 HRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXXX 724
HRLST+RNA I F+ G+I E+G+H EL+ K+ G+Y +V Q
Sbjct: 589 HRLSTVRNADVIAGFEDGVIVEQGSHSELMKKE-GVYFKLVNMQ----TSGSQIQSEEFE 643
Query: 725 XXXHRSFHRDSVTSDEERELQQSLARD--STRLRQSMISTTTQVPXXXXXXXXXXXXXXG 898
++ R + + R + S ++ ++++ Q + T
Sbjct: 644 LNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETD------------GLEAN 691
Query: 899 AMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSI-KA 1075
S + K E ++ V + G PAFS+++ ++ I G D V K
Sbjct: 692 VPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKC 751
Query: 1076 LLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVG 1255
+ SL F+ L + + G GKAGE ++ RLR F+ +++QD S+FDD +++ G
Sbjct: 752 NIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTG 811
Query: 1256 SLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXX 1435
+L++RLATDA VQ A RLA + I +L G+ ++F YGW + +
Sbjct: 812 ALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSG 871
Query: 1436 XXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAI 1615
L +RD A ++ TE+I N +TV +LT++ + P+R ++
Sbjct: 872 IVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSV 931
Query: 1616 VRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAA 1795
+ ++F+++ +F+ +++A + FG +LI N V V A+ ++++ A+
Sbjct: 932 QKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHAS 991
Query: 1796 SYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFAYPNRRRQLV 1972
S+ P+Y +A++SA +F + ++ +ID+ G P +GNI V F YP R V
Sbjct: 992 SFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPV 1051
Query: 1973 LDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKID-------DSDIRDLS 2131
L G ++ GQT+ALVG SGCGKST +QL+ER+YD L G+V +D + + L+
Sbjct: 1052 LQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLN 1111
Query: 2132 VKHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGY 2305
V+ LR + +V QEP LF+ +I ENI YG + ++QD++ AA ANIH F+ LP Y
Sbjct: 1112 VQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKY 1171
Query: 2306 DTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGR 2485
+T VG G +LSGGQKQR+AIARA++R P+ILLLDEATSALDTESEK+VQEALDKAR GR
Sbjct: 1172 ETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGR 1231
Query: 2486 TCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
TC+VIAHRLSTIQNAD I+V +NG+ E GTHQ LLA++G+Y+ +V Q+
Sbjct: 1232 TCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1281
Score = 331 bits (849), Expect = 5e-89
Identities = 186/488 (38%), Positives = 279/488 (57%), Gaps = 1/488 (0%)
Frame = +2
Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
++R F I++Q+ +FD + + L +RL D + I ++ + + F G
Sbjct: 148 KIRQKFFHAILRQEIGWFDIN--DTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAG 205
Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
V F GW + + L +++ + +A + E++ +T
Sbjct: 206 FIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRT 265
Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
V A Q + + ++ I + + ++S +A + ++A+A+ +G L+ +
Sbjct: 266 VIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVIS 325
Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
T V ++ + + SV AA + AR +A ++F +I ID+ G
Sbjct: 326 KEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGH 385
Query: 1898 TP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
P +IKGN+ V+F+YP+R +L G N+ GQTVALVG SGCGKSTT+QLI+R
Sbjct: 386 KPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRL 445
Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
YD G++ ID DIR+ +V +LR+ I +V QEP LF+ TI ENI YG N+T D+++KA
Sbjct: 446 YDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKA 505
Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
AN + F+M LP +DT VG G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDT
Sbjct: 506 VKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 565
Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
ESE VQ ALDKAR GRT +VIAHRLST++NAD I +G +E+G+H L+ + G+Y+
Sbjct: 566 ESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYF 625
Query: 2615 RLVEKQSS 2638
+LV Q+S
Sbjct: 626 KLVNMQTS 633
>gi|17567265|ref|NP_510126.1| P-GlycoProtein related (pgp-12)
[Caenorhabditis elegans]
gi|7499663|pir||T21266 hypothetical protein F22E10.1 - Caenorhabditis
elegans
gi|3876291|emb|CAA91799.1| Hypothetical protein F22E10.1
[Caenorhabditis elegans]
Length = 1318
Score = 643 bits (1658), Expect = 0.0
Identities = 363/888 (40%), Positives = 535/888 (59%), Gaps = 11/888 (1%)
Frame = +2
Query: 2 ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
++K+L G++ V PG +VALVGHSGCGKSTS+GLL R Y G + +DG ++ NI W
Sbjct: 431 KVKVLNGLNLTVKPGTSVALVGHSGCGKSTSVGLLTRLYEPEGGKVMIDGQDVRSLNIDW 490
Query: 182 LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
LR T+GIVQQEPI+F T+ N+ +G+ T +D+ CKMANAH+FI K+ + Y+T+IG
Sbjct: 491 LRKTVGIVQQEPILFNDTIHNNLLIGNPSATREDMIRVCKMANAHDFIQKMPNGYETMIG 550
Query: 362 AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
G+VQLSGGQKQRVAIAR ++R P++LLLDEATSALD +SE +VQ+AL+ A++GRTT+ I
Sbjct: 551 DGSVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALNNAAKGRTTIMI 610
Query: 542 AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
AHRLSTIR A KI+ F+ G+I E G H+EL++ G YA +V+AQ+ + +
Sbjct: 611 AHRLSTIREADKIVFFENGVIVESGNHEELVALG-GRYAKLVEAQKFKESDDIEDNGDEH 669
Query: 722 XXXXHRSFHRDSVTSDEE--RELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXXXX 895
D ++S + + +SLA + + T +
Sbjct: 670 EEETSTVGRHDRLSSRQVSFHKSCESLASADLEIGYASTFNTFTLKTAQEEIENEDFAEE 729
Query: 896 --------GAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAG 1051
G + + DIFK A + + F ++RG + ++G +F
Sbjct: 730 VQRVMEEDGVINSGYLDIFKNAQGNYLYLSVGTFFAILRGSELALLANMFGFVFAAFKEP 789
Query: 1052 GDDVSIKAL-LNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASY 1228
D++ +KAL L + ++ L I+ +ISG+L E + + R+ F+N++ QDAS+
Sbjct: 790 EDEM-VKALGLIFILYVALGLFVFITQVISGTLFTIVAENLGLKFRVQSFKNLLYQDASF 848
Query: 1229 FDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXX 1408
FD+ H G L +RLA+DAPNV+A +D R+ +V+ I S+ + + + W +A I
Sbjct: 849 FDNPAHAPGKLITRLASDAPNVKAVVDTRMLQVIYSITSITINLITGYIFCWRIA-IAGT 907
Query: 1409 XXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAA 1588
Y R EA ++ E I + KT+Q LT + + A
Sbjct: 908 IMIVLFATMMISMAYKIARENLKQIRKDEAGKIAIEIIESVKTIQLLTSTQRFLTHYKDA 967
Query: 1589 SKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNM 1768
H+ + + QS++ A++ +F+ + + Y G L+ + F+ I + M
Sbjct: 968 QLVQHKSEMRKSYIQSVNNAISQTFMYFAMFVCYGVGTPLMYHGIVEAEPTFRAINCMMM 1027
Query: 1769 ASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAY 1948
S++VM ++ FPE+V+A+ +AG++F +I +KS + + G+ I+GN+ V F+Y
Sbjct: 1028 GSVAVMHSSHNFPEFVKAKTAAGMLFKLIYRKSKTGDV-MEGNNTEIRGNVLFESVKFSY 1086
Query: 1949 PNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDL 2128
P R Q V+ + SA+ GQTVALVGPSG GKST I ++ER+YD G+++ID +I+ L
Sbjct: 1087 PQRPMQPVMTDLHFSAHSGQTVALVGPSGTGKSTCIAMLERFYDVSGGALRIDGQNIKSL 1146
Query: 2129 SVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYD 2308
S+ HLR +ALVGQEP LF TI+EN+ +GL++++ ++V +A LAN F+ LP G D
Sbjct: 1147 SLHHLRTQMALVGQEPRLFAGTIKENVCFGLKDVSVEKVHQALELANASRFLANLPAGID 1206
Query: 2309 TSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRT 2488
T VG GG+LSGGQKQR+AIARA+VRDPKILLLDEATSALD+ESE+ VQEALD+AR GRT
Sbjct: 1207 TEVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRT 1266
Query: 2489 CVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
C+ IAHRLS+IQN+D I+ +G E G H L++ RG YY L++KQ
Sbjct: 1267 CITIAHRLSSIQNSDLIVYIDHGMVQEAGNHAHLMSLRGKYYNLIKKQ 1314
Score = 311 bits (796), Expect = 7e-83
Identities = 189/582 (32%), Positives = 307/582 (52%), Gaps = 8/582 (1%)
Frame = +2
Query: 911 SLFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKIL---SAGGDDVSIKAL 1078
+L +F+YA + + + + I G P I+ G + L +A DD A+
Sbjct: 77 TLLGLFRYAERTDYALLCFGIFLSFISGIAQPGLGIIAGNITNSLLIHNATSDDFYDSAM 136
Query: 1079 LNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGS 1258
N F + I + ++ +++ ++I++Q+A +FD +++ G+
Sbjct: 137 TNVWLFGGIGIIVLIVNFVQYMCFQYCCIRITSKMKQHYIQSILRQNAGWFD--KNHSGT 194
Query: 1259 LTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXX 1438
LT++L + + I +L ++ G+V G+ ++F+Y W +A +
Sbjct: 195 LTTKLHDNMERINEGIGDKLGVLIRGMVMFVAGIVISFFYEWRLALMMMGIGPLCCVCMS 254
Query: 1439 XXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIV 1618
+ +++ +A + ES+ +TVQA QE M + +T AI
Sbjct: 255 LMSRSMSSFTSKELAGVGKAGSIAEESLMGVRTVQAFNGQEEMVEKYTVELGKGKSFAIQ 314
Query: 1619 RGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWS---TPYTVFQVIEALNMASMSVML 1789
+GLW + + F+ F +G L+ W TP VF V+ ++ + + + L
Sbjct: 315 KGLWGGVFGGIFLLFLFSYFGGGIYYGGQLL--RWKIIETPGDVFIVVISMLIGAYFLGL 372
Query: 1790 AASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFAYPNRRRQ 1966
+ + + AR++A ++ +I + ID G T + G + V+F YP R++
Sbjct: 373 ISPHLMVLLNARVAAATIYEIIDRTPDIDVYSTEGQKMTNVVGKVVFEEVHFRYPTRKKV 432
Query: 1967 LVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLR 2146
VL+G N++ G +VALVG SGCGKST++ L+ R Y+ G V ID D+R L++ LR
Sbjct: 433 KVLNGLNLTVKPGTSVALVGHSGCGKSTSVGLLTRLYEPEGGKVMIDGQDVRSLNIDWLR 492
Query: 2147 DNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGAS 2326
+ +V QEP LFN TI N+ G + T++ + + +AN H F+ +P+GY+T +G
Sbjct: 493 KTVGIVQQEPILFNDTIHNNLLIGNPSATREDMIRVCKMANAHDFIQKMPNGYETMIGDG 552
Query: 2327 GGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAH 2506
+LSGGQKQRVAIAR ++RDPK+LLLDEATSALD +SE +VQ AL+ A GRT ++IAH
Sbjct: 553 SVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALNNAAKGRTTIMIAH 612
Query: 2507 RLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
RLSTI+ ADKI+ NG +E G H+ L+A G Y +LVE Q
Sbjct: 613 RLSTIREADKIVFFENGVIVESGNHEELVALGGRYAKLVEAQ 654
Score = 202 bits (515), Expect = 3e-50
Identities = 106/224 (47%), Positives = 152/224 (67%)
Frame = +2
Query: 11 ILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWLRS 190
++ + F + G+TVALVG SG GKST I +L RFY+ G +++DG I+ ++ LR+
Sbjct: 1094 VMTDLHFSAHSGQTVALVGPSGTGKSTCIAMLERFYDVSGGALRIDGQNIKSLSLHHLRT 1153
Query: 191 TIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIGAGA 370
+ +V QEP +F T+ EN+ G ++ + + +A ++ANA F+ L DT +G
Sbjct: 1154 QMALVGQEPRLFAGTIKENVCFGLKDVSVEKVHQALELANASRFLANLPAGIDTEVGEKG 1213
Query: 371 VQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIAHR 550
QLSGGQKQR+AIARA+VR P+ILLLDEATSALD+ESER VQ ALD+A EGRT + IAHR
Sbjct: 1214 GQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHR 1273
Query: 551 LSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEI 682
LS+I+N+ I+ D G++ E G H L+S G Y +++K Q++
Sbjct: 1274 LSSIQNSDLIVYIDHGMVQEAGNHAHLMSL-RGKYYNLIKKQDL 1316