Homology by BLASTX


BLASTX 2.2.4 [Aug-26-2002]
Query= F42E11_1
         (2641 letters)

Database: /home/niguts/usr02/tshini/ykclst/db/nr.seq
           1,967,186 sequences; 661,712,633 total letters


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|17569143|ref|NP_509901.1| P-GlycoProtein related (pgp-3) [Cae...  1614   0.0
gi|283552|pir||S27338 P-glycoprotein C - Caenorhabditis elegans ...  1578   0.0
gi|39594784|emb|CAE70652.1| Hypothetical protein CBG17357 [Caeno...  1514   0.0
gi|39594783|emb|CAE70651.1| Hypothetical protein CBG17356 [Caeno...  1365   0.0
gi|17569145|ref|NP_509902.1| P-GlycoProtein related (pgp-4) [Cae...  1365   0.0
gi|39595964|emb|CAE67467.1| Hypothetical protein CBG12969 [Caeno...   753   0.0
gi|17558664|ref|NP_507487.1| P-GlycoProtein related (pgp-9) [Cae...   732   0.0
gi|39587899|emb|CAE67917.1| Hypothetical protein CBG13514 [Caeno...   712   0.0
gi|39585393|emb|CAE61715.1| Hypothetical protein CBG05664 [Caeno...   710   0.0
gi|283551|pir||S27337 multidrug resistance protein A - Caenorhab...   692   0.0
gi|17541710|ref|NP_502413.1| P-GlycoProtein related (pgp-1) [Cae...   692   0.0
gi|17567269|ref|NP_510128.1| P-GlycoProtein related (146.8 kD) (...   692   0.0
gi|39587988|emb|CAE57219.1| Hypothetical protein CBG00079 [Caeno...   689   0.0
gi|72477|pir||DVHY1C multidrug resistance protein 1 - Chinese ha...   675   0.0
gi|126924|sp|P21448|MDR1_CRIGR Multidrug resistance protein 1 (P...   675   0.0
gi|191157|gb|AAA37005.1| p-glycoprotein                               675   0.0
gi|39595370|emb|CAE60408.1| Hypothetical protein CBG04013 [Caeno...   673   0.0
gi|22759019|gb|AAN05645.1| multidrug resistance p-glycoprotein [...   673   0.0
gi|46394982|gb|AAS91647.1| multidrug resistance protein 1; P-gly...   673   0.0
gi|8926217|gb|AAF81747.1| his-tagged-multidrug resistance glycop...   673   0.0
gi|17508505|ref|NP_491707.1| P-GlycoProtein related (pgp-2) [Cae...   672   0.0
gi|307180|gb|AAA59575.1| P-glycoprotein [Homo sapiens]                672   0.0
gi|2506118|sp|P08183|MDR1_HUMAN Multidrug resistance protein 1 (...   672   0.0
gi|2353264|gb|AAB69423.1| P-glycoprotein [Homo sapiens]               672   0.0
gi|2852441|gb|AAC02113.1| multidrug resistance p-glycoprotein [C...   672   0.0
gi|72475|pir||DVMS1A multidrug resistance protein 1a - mouse (fr...   671   0.0
gi|6755048|ref|NP_035206.1| ATP-binding cassette, sub-family B (...   671   0.0
gi|266517|sp|P21447|MDR3_MOUSE Multidrug resistance protein 3 (P...   671   0.0
gi|126928|sp|P21449|MDR2_CRIGR Multidrug resistance protein 2 (P...   671   0.0
gi|42741659|ref|NP_000918.2| ATP-binding cassette sub-family B m...   671   0.0
gi|45382457|ref|NP_990225.1| ABC transporter protein [Gallus gal...   671   0.0
gi|31442763|gb|AAN07780.2| multidrug resistance p-glycoprotein [...   671   0.0
gi|46394984|gb|AAS91648.1| multidrug resistance protein; P-glyco...   671   0.0
gi|22775296|gb|AAN07779.1| multidrug resistance p-glycoprotein [...   671   0.0
gi|25297453|pir||D87789 protein C34G6.4 [imported] - Caenorhabdi...   670   0.0
gi|833699|gb|AAA75000.1| multidrug resistance protein >gnl|BL_OR...   669   0.0
gi|6755046|ref|NP_035205.1| ATP-binding cassette, sub-family B (...   668   0.0
gi|2149087|gb|AAB58489.1| multidrug resistance protein-1 [Ovis a...   667   0.0
gi|39587987|emb|CAE57218.1| Hypothetical protein CBG00078 [Caeno...   667   0.0
gi|1362689|pir||S55692 multidrug resistance protein homolog (mdr...   666   0.0
gi|39587992|emb|CAE57223.1| Hypothetical protein CBG00086 [Caeno...   665   0.0
gi|25453370|ref|NP_036755.2| P-glycoprotein/multidrug resistance...   665   0.0
gi|25453402|ref|NP_596892.1| ATP-binding cassette, sub-family B ...   665   0.0
gi|46394986|gb|AAS91649.1| multidrug resistance protein 1a; P-gl...   665   0.0
gi|7511698|pir||T31073 multidrug resistance p-glycoprotein - nem...   664   0.0
gi|48267183|gb|AAQ63650.3| multi-drug resistance P-glycoprotein ...   664   0.0
gi|50732589|ref|XP_418707.1| PREDICTED: similar to ATP-binding c...   659   0.0
gi|6679297|ref|NP_032856.1| ATP-binding cassette, sub-family B (...   659   0.0
gi|4505771|ref|NP_000434.1| ATP-binding cassette, subfamily B, m...   658   0.0
gi|6981354|ref|NP_036822.1| ATP-binding cassette, sub-family B (...   656   0.0
gi|1170902|sp|P43245|MDR1_RAT Multidrug resistance protein 1 (P-...   655   0.0
gi|40644181|emb|CAC86600.1| multidrug resistance protein [Platic...   653   0.0
gi|126930|sp|P23174|MDR3_CRIGR Multidrug resistance protein 3 (P...   653   0.0
gi|9961250|ref|NP_061337.1| ATP-binding cassette, subfamily B, m...   651   0.0
gi|17567265|ref|NP_510126.1| P-GlycoProtein related (pgp-12) [Ca...   643   0.0
gi|17567267|ref|NP_510127.1| P-GlycoProtein related (pgp-13) [Ca...   631   e-179
gi|39587990|emb|CAE57221.1| Hypothetical protein CBG00083 [Caeno...   631   e-179
gi|45361353|ref|NP_989254.1| hypothetical protein MGC76216 [Xeno...   630   e-179
gi|27656757|gb|AAO20901.1| Mdr3 [Takifugu rubripes]                   624   e-177
gi|9961252|ref|NP_061338.1| ATP-binding cassette, subfamily B, m...   621   e-176
gi|38073917|ref|XP_283101.2| similar to multidrug resistance p-g...   619   e-175
gi|31213429|ref|XP_315658.1| ENSANGP00000021663 [Anopheles gambi...   615   e-174
gi|4574224|gb|AAD23956.1| multidrug resistance transporter homol...   613   e-174
gi|13929072|ref|NP_113948.1| ATP-binding cassette, sub-family B ...   613   e-174
gi|7514034|pir||T42228 P-glycoprotein sister - rat >gnl|BL_ORD_I...   613   e-174
gi|11038656|ref|NP_066302.1| ATP-binding cassette, sub-family B,...   608   e-172
gi|50507726|emb|CAA94219.3| Hypothetical protein T21E8.2 [Caenor...   606   e-171
gi|6472653|dbj|BAA87071.1| multi-drug resistance related mRNA [F...   606   e-171
gi|17569907|ref|NP_509813.1| P-GlycoProtein related (pgp-6) [Cae...   605   e-171
gi|4704820|gb|AAD28285.1| bile salt export pump [Homo sapiens]        603   e-171
gi|27656758|gb|AAO20902.1| Mdr2 [Takifugu rubripes]                   603   e-171
gi|12643301|sp|O95342|AB11_HUMAN Bile salt export pump (ATP-bind...   603   e-171
gi|21536378|ref|NP_003733.2| ATP-binding cassette, sub-family B ...   603   e-171
gi|17569909|ref|NP_509812.1| P-GlycoProtein related (pgp-7) [Cae...   599   e-170
gi|22026798|ref|NP_523740.2| CG8523-PA [Drosophila melanogaster]...   598   e-169
gi|266518|sp|Q00449|MDR4_DROME Multidrug resistance protein homo...   598   e-169
gi|24653245|ref|NP_523724.2| CG3879-PA [Drosophila melanogaster]...   598   e-169
gi|40644167|emb|CAC86593.1| sister of P-glycoprotein [Platichthy...   597   e-169
gi|39594939|emb|CAE70807.1| Hypothetical protein CBG17569 [Caeno...   595   e-168
gi|48094917|ref|XP_394305.1| similar to ENSANGP00000021663 [Apis...   595   e-168
gi|5733124|gb|AAD49436.1| P-glycoprotein [Onchocerca volvulus]        593   e-168
gi|14030565|gb|AAK52958.1| bile salt export pump [Raja erinacea]      590   e-167
gi|157873|gb|AAA16186.1| P-glycoprotein/multidrug resistance pro...   590   e-167
gi|1079107|pir||A47377 multidrug resistance protein Mdr50 - frui...   590   e-167
gi|33307712|gb|AAQ03033.1| P-glycoprotein [Homo sapiens]              587   e-166
gi|7511495|pir||T18940 multidrug resistance protein homolog - Ca...   587   e-166
gi|17550138|ref|NP_509810.1| P-GlycoProtein related (pgp-5) [Cae...   587   e-166
gi|25146777|ref|NP_509811.2| P-GlycoProtein related (pgp-8) [Cae...   586   e-166
gi|24659289|ref|NP_648040.1| CG10226-PA [Drosophila melanogaster...   582   e-164
gi|18496818|gb|AAL74250.1| ABC transporter AbcB3 [Dictyostelium ...   578   e-163
gi|50750485|ref|XP_422016.1| PREDICTED: similar to liver bile sa...   577   e-163
gi|12585141|sp|Q9N0V3|AB11_RABIT Bile salt export pump (ATP-bind...   576   e-163
gi|393116|gb|AAA93553.1| P-glycoprotein 5                             575   e-162
gi|422286|pir||S30328 multidrug resistance protein 2 - Entamoeba...   575   e-162
gi|36413607|ref|NP_848654.2| ATP-binding cassette, sub-family B,...   575   e-162
gi|13641444|gb|AAK31736.1| p-glycoprotein [Mucor racemosus]           570   e-161
gi|21464386|gb|AAM51996.1| RE14657p [Drosophila melanogaster]         568   e-160
gi|17136662|ref|NP_476831.1| CG10181-PA [Drosophila melanogaster...   568   e-160
gi|103252|pir||B41249 multidrug resistance protein homolog Mdr65...   568   e-160
gi|422285|pir||S30327 multidrug resistance protein 1 - Entamoeba...   568   e-160
gi|46390962|dbj|BAD16475.1| putative multidrug resistance p-glyc...   566   e-160
gi|18496816|gb|AAL74249.1| ABC transporter AbcB2 [Dictyostelium ...   566   e-160
gi|16304396|gb|AAL15148.1| multidrug resistance transporter-like...   565   e-159
gi|2673951|gb|AAB88657.1| multidrug resistance protein 1 [Asperg...   565   e-159
gi|5456701|gb|AAD43626.1| multidrug resistance protein MDR [Emer...   564   e-159
gi|49089458|ref|XP_406437.1| hypothetical protein AN2300.2 [Aspe...   564   e-159
gi|50260330|gb|EAL22989.1| hypothetical protein CNBA7570 [Crypto...   561   e-158
gi|15228695|ref|NP_191774.1| multidrug resistant (MDR) ABC trans...   560   e-158
gi|22535563|dbj|BAC10738.1| putative multidrug resistance protei...   559   e-157
gi|11346278|pir||T43261 multidrug resistance protein 1 - fungus ...   559   e-157
gi|27368867|emb|CAD59591.1| MDR-like ABC transporter [Oryza sati...   556   e-156
gi|50543630|ref|XP_499981.1| hypothetical protein [Yarrowia lipo...   554   e-156
gi|15229473|ref|NP_189475.1| ABC transporter family protein [Ara...   553   e-155
gi|38345252|emb|CAD41096.2| OSJNBb0011N17.13 [Oryza sativa (japo...   553   e-155
gi|50546639|ref|XP_500789.1| hypothetical protein [Yarrowia lipo...   551   e-155
gi|15147363|gb|AAG01549.3| multidrug resistance protein MDR [Tri...   551   e-155
gi|15217785|ref|NP_171753.1| multidrug resistance P-glycoprotein...   551   e-155
gi|15226477|ref|NP_182223.1| multidrug resistant (MDR) ABC trans...   550   e-155
gi|18033873|gb|AAL57243.1| ATP-binding cassette transporter ABC4...   549   e-154
gi|34894326|ref|NP_908488.1| unnamed protein product [Oryza sati...   548   e-154
gi|15237456|ref|NP_199466.1| ABC transporter family protein [Ara...   548   e-154
gi|15228506|ref|NP_189528.1| multidrug resistance P-glycoprotein...   548   e-154
gi|24324262|gb|AAN28720.2| MDR-like p-glycoprotein [Arabidopsis ...   548   e-154
gi|27368859|emb|CAD59587.1| MDR-like ABC transporter [Oryza sati...   546   e-154
gi|19032275|dbj|BAB85651.1| multidrug resistance protein 1 homol...   546   e-154
gi|25297456|pir||F86155 probable ABC transporter [imported] - Ar...   545   e-153
gi|39594943|emb|CAE70811.1| Hypothetical protein CBG17574 [Caeno...   545   e-153
gi|15217786|ref|NP_171754.1| multidrug resistance P-glycoprotein...   545   e-153
gi|26449438|dbj|BAC41846.1| putative P-glycoprotein [Arabidopsis...   545   e-153
gi|27368865|emb|CAD59590.1| MDR-like ABC transporter [Oryza sati...   541   e-152
gi|4204793|gb|AAD10836.1| P-glycoprotein [Solanum tuberosum]          540   e-152
gi|14715462|dbj|BAB62040.1| CjMDR1 [Coptis japonica]                  539   e-151
gi|27368869|emb|CAD59592.1| MDR-like ABC transporter [Oryza sati...   538   e-151
gi|27368847|emb|CAD59581.1| MDR-like ABC transporter [Oryza sati...   537   e-151
gi|39594940|emb|CAE70808.1| Hypothetical protein CBG17570 [Caeno...   537   e-151
gi|33299999|emb|CAA88940.3| Hypothetical protein DH11.3 [Caenorh...   537   e-151
gi|27368849|emb|CAD59582.1| MDR-like ABC transporter [Oryza sati...   535   e-150
gi|34911450|ref|NP_917072.1| putative multidrug resistance prote...   535   e-150
gi|15228052|ref|NP_181228.1| multidrug resistance P-glycoprotein...   535   e-150
gi|27368855|emb|CAD59585.1| MDR-like ABC transporter [Oryza sati...   535   e-150
gi|50556486|ref|XP_505651.1| hypothetical protein [Yarrowia lipo...   535   e-150
gi|22331385|ref|NP_683599.1| P-glycoprotein, putative [Arabidops...   534   e-150
gi|9294577|dbj|BAB02858.1| multidrug resistance p-glycoprotein; ...   534   e-150
gi|15232978|ref|NP_189480.1| P-glycoprotein, putative [Arabidops...   533   e-149
gi|22655312|gb|AAM98246.1| putative ABC transporter [Arabidopsis...   532   e-149
gi|50732439|ref|XP_418636.1| PREDICTED: similar to Multidrug res...   532   e-149
gi|21740907|emb|CAD40903.1| OSJNBa0036B21.21 [Oryza sativa (japo...   532   e-149
gi|34913530|ref|NP_918112.1| putative multidrug resistance prote...   532   e-149
gi|27368851|emb|CAD59583.1| MDR-like ABC transporter [Oryza sati...   530   e-149
gi|15234322|ref|NP_192091.1| multidrug resistance P-glycoprotein...   530   e-149
gi|25455873|pir||T52319 P-glycoprotein-like protein pgp3 [import...   530   e-149
gi|15234323|ref|NP_192092.1| multidrug resistance P-glycoprotein...   530   e-149
gi|15217809|ref|NP_174122.1| multidrug resistance P-glycoprotein...   530   e-149
gi|7494503|pir||T30855 multidrug resistance protein 2 - fluke (S...   526   e-147
gi|7498268|pir||T20386 hypothetical protein DH11.3 - Caenorhabdi...   525   e-147
gi|17532731|ref|NP_495674.1| P-GlycoProtein related (pgp-11) [Ca...   525   e-147
gi|15217776|ref|NP_174115.1| multidrug resistance P-glycoprotein...   523   e-147
gi|15232977|ref|NP_189479.1| P-glycoprotein, putative [Arabidops...   521   e-146
gi|6671365|gb|AAF23176.1| P-glycoprotein [Gossypium hirsutum]         519   e-145
gi|7493911|pir||T30882 multidrug resistance protein 1 - Aspergil...   518   e-145
gi|34913544|ref|NP_918119.1| putative multidrug resistance prote...   516   e-144
gi|45735908|dbj|BAD12940.1| putative P-glycoprotein 1 [Oryza sat...   516   e-144
gi|22328760|ref|NP_193539.2| ABC transporter family protein [Ara...   513   e-144
gi|25407562|pir||H85202 hypothetical protein AT4g18050 [imported...   513   e-144
gi|15236067|ref|NP_194326.1| multidrug resistance P-glycoprotein...   513   e-144
gi|20466380|gb|AAM20507.1| P-glycoprotein-2 [Arabidopsis thaliana]    512   e-143
gi|39587763|emb|CAE67781.1| Hypothetical protein CBG13356 [Caeno...   511   e-143
gi|38049160|gb|AAR10387.1| P-glycoprotein 1 [Sorghum bicolor]         510   e-143
gi|46390486|dbj|BAD15946.1| putative MDR-like ABC transporter [O...   506   e-141
gi|27368839|emb|CAD59577.1| MDR-like ABC transporter [Oryza sati...   506   e-141
gi|15220188|ref|NP_172538.1| P-glycoprotein, putative [Arabidops...   504   e-141
gi|27368845|emb|CAD59580.1| MDR-like ABC transporter [Oryza sati...   504   e-141
gi|15232975|ref|NP_189477.1| ABC transporter family protein [Ara...   502   e-140
gi|9294571|dbj|BAB02852.1| multidrug resistance p-glycoprotein; ...   502   e-140
gi|7442649|pir||T06165 multidrug resistance protein 1 homolog - ...   501   e-140
gi|49080124|ref|XP_403624.1| hypothetical protein UM06009.1 [Ust...   501   e-140
gi|218550|dbj|BAA01537.1| pmd1 protein [Schizosaccharomyces pombe]    495   e-138
gi|19075765|ref|NP_588265.1| leptomycin b resistance protein, ab...   495   e-138
gi|7494131|pir||T30804 P-glycoprotein 6 - Entamoeba histolytica ...   495   e-138
gi|27368841|emb|CAD59578.1| MDR-like ABC transporter [Oryza sati...   493   e-137
gi|27368861|emb|CAD59588.1| MDR-like ABC transporter [Oryza sati...   493   e-137
gi|46129276|ref|XP_388999.1| hypothetical protein FG08823.1 [Gib...   486   e-135
gi|34910738|ref|NP_916716.1| putative P-glycoprotein [Oryza sati...   485   e-135
gi|27368843|emb|CAD59579.1| MDR-like ABC transporter [Oryza sati...   482   e-134
gi|37806003|dbj|BAC99416.1| putative MDR-like ABC transporter [O...   482   e-134
gi|38098857|gb|AAR11078.1| ATP binding cassette transporter [Lep...   481   e-134
gi|24960750|gb|AAN65444.1| Hypothetical protein [Oryza sativa (j...   478   e-133
gi|25297460|pir||B86240 protein F20B24.12 [imported] - Arabidops...   475   e-132
gi|37695542|gb|AAR00316.1| PGP1; ZMPGP1 [Zea mays]                    474   e-132
gi|49089656|ref|XP_406486.1| hypothetical protein AN2349.2 [Aspe...   471   e-131
gi|5456699|gb|AAD43625.1| ATP-binding cassette multidrug transpo...   471   e-131
gi|7442651|pir||T14805 hypothetical protein F15J5.20 - Arabidops...   470   e-131
gi|7508147|pir||T25083 hypothetical protein T21E8.1 - Caenorhabd...   464   e-129
gi|9294508|dbj|BAB02613.1| P-glycoprotein; multi-drug resistance...   462   e-128
gi|7508148|pir||T25082 hypothetical protein T21E8.2 - Caenorhabd...   461   e-128
gi|49092568|ref|XP_407745.1| hypothetical protein AN3608.2 [Aspe...   457   e-127
gi|46114962|ref|XP_383499.1| hypothetical protein FG03323.1 [Gib...   456   e-126
gi|46125007|ref|XP_387057.1| hypothetical protein FG06881.1 [Gib...   455   e-126
gi|4587971|gb|AAD25925.1| ABC transporter protein AtrC [Emericel...   450   e-125
gi|730011|sp|Q06034|MDR1_LEIEN Multidrug resistance protein 1 (P...   449   e-124
gi|2360941|gb|AAB69130.1| P-glycoprotein                              445   e-123
gi|46109604|ref|XP_381860.1| hypothetical protein FG01684.1 [Gib...   444   e-123
gi|38099353|gb|EAA46710.1| hypothetical protein MG09931.4 [Magna...   440   e-121
gi|4521245|dbj|BAA76299.1| LAMDR1 [Leishmania mexicana amazonensis]   439   e-121
gi|25990364|gb|AAN76500.1| P-glycoprotein [Homo sapiens]              439   e-121
gi|159363|gb|AAA02977.1| P-glycoprotein                               438   e-121
gi|4768949|gb|AAD29692.1| sister of P-glycoprotein [Fundulus het...   435   e-120
gi|191159|gb|AAA37006.1| P-glycoprotein (pgp1)                        432   e-119
gi|38108326|gb|EAA54363.1| hypothetical protein MG02348.4 [Magna...   432   e-119
gi|49138261|ref|XP_413479.1| hypothetical protein AN9342.2 [Aspe...   432   e-119
gi|72478|pir||DVHY2C multidrug resistance protein 2 - Chinese ha...   431   e-119
gi|7522025|pir||T30191 multidrug resistance protein 1 - Aureobas...   430   e-118
gi|32402932|ref|XP_322079.1| hypothetical protein [Neurospora cr...   428   e-118
gi|7442650|pir||JG0166 LaMDR1 protein - Leishmania mexicana amaz...   427   e-118
gi|46111809|ref|XP_382962.1| hypothetical protein FG02786.1 [Gib...   424   e-117
gi|49081308|ref|XP_404076.1| hypothetical protein UM06461.1 [Ust...   424   e-117
gi|34935680|ref|XP_234725.2| similar to P-glycoprotein [Rattus n...   422   e-116
gi|20530737|gb|AAM27211.1| multidrug resistance protein 4 [Asper...   416   e-114
gi|42820674|emb|CAF31987.1| ABC transporter, putative [Aspergill...   416   e-114
gi|46116988|ref|XP_384512.1| hypothetical protein FG04336.1 [Gib...   416   e-114
gi|46401536|dbj|BAD16632.1| LAMDR2 [Leishmania amazonensis]           414   e-114
gi|38101651|gb|EAA48581.1| hypothetical protein MG00239.4 [Magna...   411   e-113
gi|191153|gb|AAA37003.1| p-glycoprotein                               410   e-113
gi|32418014|ref|XP_329485.1| hypothetical protein [Neurospora cr...   410   e-112
gi|49097828|ref|XP_410374.1| hypothetical protein AN6237.2 [Aspe...   409   e-112
gi|46107316|ref|XP_380717.1| hypothetical protein FG00541.1 [Gib...   405   e-111
gi|47225423|emb|CAG11906.1| unnamed protein product [Tetraodon n...   395   e-108
gi|18033871|gb|AAL57242.1| ATP-binding cassette transporter ABC3...   382   e-104
gi|32400322|dbj|BAC78652.1| ABC transporter [Aspergillus oryzae]      381   e-104
gi|45735909|dbj|BAD12941.1| putative P-glycoprotein 1 [Oryza sat...   371   e-101
gi|18253111|dbj|BAB83959.1| multidrug resistance p-glycoprotein ...   357   1e-96
gi|13346110|gb|AAK19598.1| putative ABC transporter [Sterkiella ...   351   4e-95
gi|45775220|gb|AAK83023.2| truncated P-glycoprotein [Rattus norv...   345   2e-93
gi|17567271|ref|NP_510129.1| P-GlycoProtein related (pgp-15) [Ca...   336   2e-90
gi|1174535|gb|AAA86666.1| ATP-binding cassette protein [Fasciola...   335   3e-90
gi|34525|emb|CAA29547.1| P-glycoprotein (431 AA) [Homo sapiens]       332   4e-89
gi|41052996|dbj|BAD07905.1| putative MDR-like ABC transporter [O...   325   3e-87
gi|47900485|gb|AAT39242.1| putative P-glycoprotein [Oryza sativa...   322   4e-86
gi|22974777|ref|ZP_00020923.1| hypothetical protein [Chloroflexu...   314   8e-84
gi|47218631|emb|CAG04960.1| unnamed protein product [Tetraodon n...   313   1e-83
gi|10241621|emb|CAC09461.1| putative P-glycoprotein [Oryza sativ...   309   3e-82
gi|47225422|emb|CAG11905.1| unnamed protein product [Tetraodon n...   309   3e-82
gi|45735907|dbj|BAD12939.1| putative P-glycoprotein 1 [Oryza sat...   307   7e-82
gi|34851887|ref|XP_341718.1| similar to ABC transporter [Rattus ...   306   1e-81
gi|19698967|gb|AAL91219.1| P-glycoprotein, putative [Arabidopsis...   305   5e-81
gi|9992887|gb|AAG11416.1| TagA [Dictyostelium discoideum]             303   1e-80
gi|18496655|gb|AAL74187.1| putative ABC transporter [Triticum mo...   302   2e-80
gi|7510080|pir||T31617 hypothetical protein Y50E8A.m - Caenorhab...   302   3e-80
gi|19335724|gb|AAL85486.1| transporter associated with antigen p...   302   3e-80
gi|22327455|ref|NP_198720.2| ABC transporter (TAP2) [Arabidopsis...   302   3e-80
gi|17565938|ref|NP_506645.1| HAlF transporter, PGP related (haf-...   302   3e-80
gi|9506367|ref|NP_062425.1| ATP-binding cassette, sub-family B, ...   301   4e-80
gi|12278525|gb|AAG49002.1| putative ABC transporter [Hordeum vul...   301   5e-80
gi|18496654|gb|AAL74186.1| putative ABC transporter [Triticum mo...   301   7e-80
gi|10177549|dbj|BAB10828.1| ABC transporter-like protein [Arabid...   299   2e-79
gi|12061244|gb|AAG45492.1| 36I5.4 [Oryza sativa (japonica cultiv...   298   3e-79
gi|17551158|ref|NP_509205.1| P-GlycoProtein related (pgp-10) [Ca...   298   4e-79
gi|12278526|gb|AAG49003.1| putative ABC transporter [Hordeum vul...   298   4e-79
gi|18496814|gb|AAL74248.1| ABC transporter AbcB1 [Dictyostelium ...   298   4e-79
gi|17543740|ref|NP_502776.1| HAlF transporter, PGP related (haf-...   297   1e-78
gi|39586807|emb|CAE65850.1| Hypothetical protein CBG10984 [Caeno...   296   2e-78
gi|49077780|ref|XP_402711.1| hypothetical protein UM05096.1 [Ust...   295   4e-78
gi|21326114|gb|AAM47580.1| putative ABC-transporter-like protein...   293   1e-77
gi|39583384|emb|CAE66359.1| Hypothetical protein CBG11616 [Caeno...   293   2e-77
gi|32966961|gb|AAP92331.1| multixenobiotic resistance protein [C...   292   3e-77
gi|18875456|gb|AAL74251.2| ABC transporter AbcB4 [Dictyostelium ...   287   1e-75
gi|39581765|emb|CAE74138.1| Hypothetical protein CBG21809 [Caeno...   285   4e-75
gi|27368853|emb|CAD59584.1| MDR-like ABC transporter [Oryza sati...   285   5e-75
gi|34906082|ref|NP_914388.1| putative P-glycoprotein [Oryza sati...   285   5e-75
gi|40787796|gb|AAH64930.1| ATP-binding cassette, sub-family B, m...   284   9e-75
gi|20453064|gb|AAM19777.1| At2g39480/F12L6.14 [Arabidopsis thali...   282   3e-74
gi|15225474|ref|NP_181480.1| ABC transporter family protein [Ara...   282   3e-74
gi|31216972|ref|XP_316337.1| ENSANGP00000013796 [Anopheles gambi...   281   4e-74
gi|9961244|ref|NP_036221.1| ATP-binding cassette, sub-family B, ...   281   6e-74
gi|15233244|ref|NP_191092.1| ABC transporter family protein [Ara...   280   1e-73
gi|24641565|ref|NP_572810.1| CG1824-PA [Drosophila melanogaster]...   279   3e-73
gi|50877523|emb|CAG37363.1| related to ABC-transporter, ATP-bind...   278   4e-73
gi|48892154|ref|ZP_00325566.1| COG1132: ABC-type multidrug trans...   277   8e-73
gi|47217174|emb|CAG11010.1| unnamed protein product [Tetraodon n...   276   1e-72
gi|39997358|ref|NP_953309.1| ABC transporter, ATP-binding protei...   276   1e-72
gi|2147880|pir||I48120 P-glycoprotein - Chinese hamster (fragmen...   275   3e-72
gi|12248755|dbj|BAB20265.1| mono ATP-binding cassette protein [H...   273   2e-71
gi|31206493|ref|XP_312209.1| ENSANGP00000002692 [Anopheles gambi...   272   3e-71
gi|1743406|emb|CAB05918.1| transport-associated protein [Salmo s...   271   5e-71
gi|21230937|ref|NP_636854.1| ABC transporter ATP-binding protein...   271   8e-71
gi|2119779|pir||S50217 multidrug resistance protein 3 - rat (fra...   271   8e-71
gi|39580953|emb|CAE72923.1| Hypothetical protein CBG20243 [Caeno...   269   2e-70
gi|2147879|pir||I48119 P-glycoprotein - Chinese hamster (fragmen...   268   4e-70
gi|48844191|ref|ZP_00298519.1| COG1132: ABC-type multidrug trans...   267   9e-70
gi|21242281|ref|NP_641863.1| ABC transporter ATP-binding protein...   267   1e-69
gi|28900647|ref|NP_800302.1| putative ATP-binding/permease fusio...   267   1e-69
gi|23016084|ref|ZP_00055844.1| COG1132: ABC-type multidrug trans...   266   1e-69
gi|7511165|pir||T32865 hypothetical protein ZK484.2 - Caenorhabd...   266   2e-69
gi|17511077|ref|NP_491754.1| HAlF transporter, PGP related (90.8...   266   2e-69
gi|5823088|gb|AAD53035.1| TAP2B protein [Oncorhynchus mykiss]         266   2e-69
gi|39582351|emb|CAE67600.1| Hypothetical protein CBG13145 [Caeno...   265   3e-69
gi|27366635|ref|NP_762162.1| ABC-type multidrug transport system...   265   4e-69
gi|17533971|ref|NP_495537.1| HAlF transporter, PGP related (haf-...   265   6e-69
gi|46119497|ref|ZP_00176704.2| COG1132: ABC-type multidrug trans...   264   9e-69
gi|37676347|ref|NP_936743.1| ABC-type multidrug transport system...   263   2e-68
gi|27753995|ref|NP_083296.2| RIKEN cDNA 4833412N02 [Mus musculus...   262   4e-68
gi|26339816|dbj|BAC33571.1| unnamed protein product [Mus musculus]    262   4e-68
gi|15966528|ref|NP_386881.1| PROBABLE ABC TRANSPORTER ATP-BINDIN...   261   6e-68
gi|49476161|ref|YP_034202.1| ABC transporter, ATP-binding protei...   261   6e-68
gi|47212418|emb|CAG12367.1| unnamed protein product [Tetraodon n...   261   8e-68
gi|48730042|ref|ZP_00263791.1| COG1132: ABC-type multidrug trans...   261   8e-68
gi|5911322|gb|AAD55751.1| transporter associated with antigen pr...   261   8e-68
gi|22298505|ref|NP_681752.1| ABC transporter ATP-binding protein...   260   1e-67
gi|34853987|ref|XP_342615.1| similar to RIKEN cDNA 4833412N02 [R...   260   1e-67
gi|27452581|gb|AAN71739.1| ABCB9-like TAP-family protein [Petrom...   260   1e-67
gi|26345292|dbj|BAC36297.1| unnamed protein product [Mus musculus]    259   2e-67
gi|48864170|ref|ZP_00318063.1| COG1132: ABC-type multidrug trans...   259   2e-67
gi|49474685|ref|YP_032727.1| ABC transporter, ATP-binding protei...   258   4e-67
gi|22095457|sp|Q9JJ59|ABC9_MOUSE ATP-binding cassette, sub-famil...   258   4e-67
gi|26006275|dbj|BAC41480.1| mKIAA1520 protein [Mus musculus]          258   4e-67
gi|9845230|ref|NP_063928.1| ATP-binding cassette, sub-family B, ...   258   5e-67
gi|18124194|gb|AAL59859.1| transporter associated with antigen p...   258   5e-67
gi|9955966|ref|NP_062571.1| ATP-binding cassette, sub-family B (...   258   7e-67
gi|11560034|ref|NP_071574.1| TAP-like ABC transporter [Rattus no...   258   7e-67
gi|15891205|ref|NP_356877.1| AGR_L_2179p [Agrobacterium tumefaci...   258   7e-67
gi|23104911|ref|ZP_00091371.1| COG1132: ABC-type multidrug trans...   258   7e-67
gi|46916508|emb|CAG23273.1| putative ATP-binding/permease fusion...   257   9e-67
gi|23475242|ref|ZP_00130531.1| COG1132: ABC-type multidrug trans...   257   9e-67
gi|15808008|ref|NP_285672.1| ABC transporter, ATP-binding protei...   257   9e-67
gi|5911326|gb|AAD55753.1| transporter associated with antigen pr...   257   1e-66
gi|5823084|gb|AAD53033.1| TAP1 protein [Oncorhynchus mykiss]          257   1e-66
gi|37521898|ref|NP_925275.1| HlyB/MsbA family ABC transporter [G...   257   1e-66
gi|50741416|ref|XP_419578.1| PREDICTED: similar to ATP-binding c...   257   1e-66
gi|8176565|dbj|BAA96370.1| ABC protein [Physarum polycephalum]        256   2e-66
gi|22959359|ref|ZP_00007012.1| COG1132: ABC-type multidrug trans...   256   2e-66
gi|1743404|emb|CAB05917.1| transport-associated protein [Salmo s...   256   2e-66
gi|15890388|ref|NP_356060.1| AGR_L_552p [Agrobacterium tumefacie...   255   3e-66
gi|13473363|ref|NP_104930.1| ABC transporter, ATP-binding protei...   255   4e-66
gi|17228136|ref|NP_484684.1| ATP-binding protein of ABC transpor...   254   6e-66
gi|7023646|dbj|BAA92038.1| unnamed protein product [Homo sapiens]     254   6e-66
gi|45548045|ref|ZP_00188081.1| COG1132: ABC-type multidrug trans...   254   6e-66
gi|23469088|ref|ZP_00124423.1| COG1132: ABC-type multidrug trans...   254   7e-66
gi|29561855|emb|CAD87788.1| SI:dZ262K18.3 (ATP-binding cassette,...   254   1e-65
gi|45506769|ref|ZP_00159120.1| COG1132: ABC-type multidrug trans...   253   1e-65
gi|21673056|ref|NP_661121.1| ABC transporter, ATP-binding protei...   253   1e-65
gi|8176563|dbj|BAA96369.1| ABC protein [Physarum polycephalum]        253   2e-65
gi|45916934|ref|ZP_00195995.2| COG1132: ABC-type multidrug trans...   253   2e-65
gi|16330165|ref|NP_440893.1| ABC transporter [Synechocystis sp. ...   253   2e-65
gi|23127899|ref|ZP_00109758.1| COG1132: ABC-type multidrug trans...   253   2e-65
gi|28199828|ref|NP_780142.1| ABC transporter ATP-binding protein...   252   3e-65
gi|39992420|gb|AAH64384.1| ABCB9 protein [Homo sapiens]               252   3e-65
gi|6005804|ref|NP_009119.1| ATP-binding cassette, sub-family B, ...   251   5e-65
gi|13123950|sp|Q9NUT2|ABC8_HUMAN ATP-binding cassette, sub-famil...   251   5e-65
gi|47575345|ref|ZP_00245380.1| COG1132: ABC-type multidrug trans...   251   5e-65
gi|48850584|ref|ZP_00304826.1| COG1132: ABC-type multidrug trans...   251   5e-65
gi|27376619|ref|NP_768148.1| HlyB/MsbA family ABC transporter [B...   251   5e-65
gi|47225421|emb|CAG11904.1| unnamed protein product [Tetraodon n...   251   5e-65
gi|22997178|ref|ZP_00041414.1| COG1132: ABC-type multidrug trans...   251   6e-65
gi|39579434|emb|CAE74830.1| Hypothetical protein CBG22668 [Caeno...   251   6e-65
gi|24374337|ref|NP_718380.1| ABC transporter, ATP-binding protei...   250   1e-64
gi|23127765|ref|ZP_00109628.1| COG1132: ABC-type multidrug trans...   250   1e-64
gi|47077792|dbj|BAD18770.1| unnamed protein product [Homo sapiens]    250   1e-64
gi|39933996|ref|NP_946272.1| ABC transporter, ATP-binding protei...   250   1e-64
gi|28379465|ref|NP_786357.1| ABC transporter, ATP-binding protei...   250   1e-64
gi|21753735|dbj|BAC04392.1| unnamed protein product [Homo sapiens]    249   2e-64
gi|23397593|ref|NP_569844.2| CG3156-PA [Drosophila melanogaster]...   249   2e-64
gi|17232685|ref|NP_489233.1| ATP-binding protein of ABC transpor...   249   2e-64
gi|5733401|gb|AAD49563.1| P-glycoprotein-like protein [Onchocerc...   249   2e-64
gi|30249744|ref|NP_841814.1| ABC transporter, fused permease and...   249   2e-64
gi|2492605|sp|P97998|MDL1_CANAL ATP-dependent permease MDL1 >gnl...   249   3e-64
gi|16264301|ref|NP_437093.1| putative lipid A + LPS core exporti...   249   3e-64
gi|46440040|gb|EAK99351.1| hypothetical protein CaO19.2615 [Cand...   248   4e-64
gi|45916645|ref|ZP_00197576.1| COG1132: ABC-type multidrug trans...   248   4e-64
gi|525293|emb|CAA53758.1| PGP1 [Trichomonas vaginalis]                248   4e-64
gi|15672293|ref|NP_266467.1| ABC transporter ATP binding and per...   248   5e-64
gi|48855938|ref|ZP_00310096.1| COG1132: ABC-type multidrug trans...   248   7e-64
gi|22995060|ref|ZP_00039543.1| COG1132: ABC-type multidrug trans...   248   7e-64
gi|28869225|ref|NP_791844.1| ABC transporter, ATP-binding/permea...   248   7e-64
gi|28210179|ref|NP_781123.1| multidrug resistance ABC transporte...   247   9e-64
gi|37781028|gb|AAP36720.1| transporter associated with antigen p...   247   9e-64
gi|46134905|ref|ZP_00158883.2| COG1132: ABC-type multidrug trans...   247   1e-63
gi|48833973|ref|ZP_00290989.1| COG1132: ABC-type multidrug trans...   246   2e-63
gi|46580081|ref|YP_010889.1| ABC transporter, ATP-binding protei...   246   2e-63
gi|33863091|ref|NP_894651.1| ABC transporter, possibly multidrug...   246   3e-63
gi|16078496|ref|NP_389315.1| yknU [Bacillus subtilis subsp. subt...   246   3e-63
gi|23502573|ref|NP_698700.1| ABC transporter, ATP binding/permea...   246   3e-63
gi|1743408|emb|CAB05919.1| transport-associated protein [Salmo s...   245   3e-63
gi|46141086|ref|ZP_00203861.1| COG1132: ABC-type multidrug trans...   245   3e-63
gi|7445902|pir||T13416 hypothetical protein 171D11.2 - fruit fly...   245   5e-63
gi|48824040|ref|ZP_00285472.1| COG1132: ABC-type multidrug trans...   245   5e-63
gi|16127504|ref|NP_422068.1| ABC transporter, HlyB/MsbA family [...   245   5e-63
gi|15963913|ref|NP_384266.1| PUTATIVE ATP-BINDING ABC TRANSPORTE...   244   6e-63
gi|33636348|dbj|BAC81752.1| hydrophobic compound transport facto...   244   6e-63
gi|37521765|ref|NP_925142.1| HlyB/MsbA family ABC transporter [G...   244   6e-63
gi|15839171|ref|NP_299859.1| ABC transporter ATP-binding protein...   244   6e-63
gi|1016270|gb|AAA79094.1| p-glycoprotein                              244   8e-63
gi|15596310|ref|NP_249804.1| probable ATP-binding/permease fusio...   244   8e-63
gi|32041123|ref|ZP_00138706.1| COG1132: ABC-type multidrug trans...   244   8e-63
gi|17986606|ref|NP_539240.1| PROBABLE TRANSPORT ATP-BINDING PROT...   244   1e-62
gi|26988843|ref|NP_744268.1| ABC efflux transporter, permease/AT...   244   1e-62
gi|34496280|ref|NP_900495.1| transport ATP-binding protein msbA ...   243   1e-62
gi|39579610|emb|CAE56497.1| Hypothetical protein CBG24214 [Caeno...   243   2e-62
gi|46130296|ref|ZP_00165119.2| COG1132: ABC-type multidrug trans...   243   2e-62
gi|27468468|ref|NP_765105.1| ABC transporter (ATP-binding protei...   243   2e-62
gi|16330032|ref|NP_440760.1| ABC transporter [Synechocystis sp. ...   243   2e-62
gi|46115926|ref|XP_383981.1| hypothetical protein FG03805.1 [Gib...   243   2e-62
gi|27365418|ref|NP_760946.1| Transport ATP-binding protein MsbA ...   242   3e-62
gi|23336111|ref|ZP_00121339.1| COG1132: ABC-type multidrug trans...   242   3e-62
gi|37680540|ref|NP_935149.1| transport ATP-binding protein MsbA ...   241   5e-62
gi|16124560|ref|NP_419124.1| ABC transporter, HlyB/MsbA family [...   241   5e-62
gi|30686893|ref|NP_194275.2| ABC transporter family protein [Ara...   241   5e-62
gi|39936328|ref|NP_948604.1| putative ABC transporter [Rhodopseu...   241   7e-62
gi|48771097|ref|ZP_00275440.1| COG1132: ABC-type multidrug trans...   241   7e-62
gi|34901502|ref|NP_912097.1| contains ESTs C74558(E31852),AU0948...   241   7e-62
gi|29348795|ref|NP_812298.1| ABC transporter, ATP-binding protei...   241   7e-62
gi|48826439|ref|ZP_00287643.1| COG1132: ABC-type multidrug trans...   241   7e-62
gi|23002311|ref|ZP_00045988.1| COG1132: ABC-type multidrug trans...   241   9e-62
gi|50085455|ref|YP_046965.1| lipid transport protein, flippase (...   240   1e-61
gi|28211454|ref|NP_782398.1| multidrug resistance ABC transporte...   240   1e-61
gi|46308813|ref|ZP_00211005.1| COG1132: ABC-type multidrug trans...   240   1e-61
gi|49475315|ref|YP_033356.1| ABC transporter, ATP-binding protei...   240   1e-61
gi|23024543|ref|ZP_00063750.1| COG1132: ABC-type multidrug trans...   240   1e-61
gi|50551833|ref|XP_503391.1| hypothetical protein [Yarrowia lipo...   239   2e-61
gi|29375380|ref|NP_814534.1| ABC transporter, ATP-binding/permea...   239   3e-61
gi|23127335|ref|ZP_00109208.1| COG1132: ABC-type multidrug trans...   238   4e-61
gi|23098860|ref|NP_692326.1| ABC transporter ATP-binding protein...   238   4e-61
gi|15924856|ref|NP_372390.1| ABC transporter homolog [Staphyloco...   238   6e-61
gi|50304659|ref|XP_452285.1| unnamed protein product [Kluyveromy...   238   6e-61
gi|30248923|ref|NP_840993.1| ABC transporter, fused permease and...   238   6e-61
gi|22970612|ref|ZP_00017667.1| hypothetical protein [Chloroflexu...   238   6e-61
gi|15894891|ref|NP_348240.1| ABC-type multidrug/protein/lipid tr...   238   7e-61
gi|31194451|ref|XP_306173.1| ENSANGP00000015516 [Anopheles gambi...   238   7e-61
gi|49477449|ref|YP_036121.1| multidrug resistance ABC transporte...   238   7e-61
gi|45521342|ref|ZP_00172862.1| COG1132: ABC-type multidrug trans...   238   7e-61
gi|17988594|ref|NP_541227.1| ABC TRANSPORTER ATP-BINDING PROTEIN...   237   9e-61
gi|23100898|ref|NP_694365.1| ABC transporter ATP-binding protein...   237   9e-61
gi|33602558|ref|NP_890118.1| putative ABC transporter [Bordetell...   237   1e-60
gi|17229638|ref|NP_486186.1| ATP-binding protein of ABC transpor...   237   1e-60
gi|23500772|ref|NP_700212.1| ABC transporter, ATP-binding/permea...   236   2e-60
gi|50510160|dbj|BAD31127.1| putative ATP-binding cassette, sub-f...   236   2e-60
gi|42781108|ref|NP_978355.1| ABC transporter, ATP-binding/permea...   236   2e-60
gi|15600190|ref|NP_253684.1| transport protein MsbA [Pseudomonas...   236   2e-60
gi|46319843|ref|ZP_00220241.1| COG1132: ABC-type multidrug trans...   236   2e-60
gi|24375163|ref|NP_719206.1| ABC transporter, ATP-binding/permea...   236   2e-60
gi|21622336|emb|CAD36977.1| probable multidrug resistance protei...   236   2e-60
gi|50590097|ref|ZP_00331525.1| COG1132: ABC-type multidrug trans...   236   2e-60
gi|46311693|ref|ZP_00212296.1| COG1132: ABC-type multidrug trans...   236   2e-60
gi|17232691|ref|NP_489239.1| ATP-binding protein of ABC transpor...   236   3e-60
gi|16077889|ref|NP_388703.1| yfiC [Bacillus subtilis subsp. subt...   236   3e-60
gi|49473726|ref|YP_031768.1| ABC transporter, ATP-binding protei...   236   3e-60
gi|42518673|ref|NP_964603.1| ABC transporter ATPase and permease...   236   3e-60
gi|50590389|ref|ZP_00331775.1| COG1132: ABC-type multidrug trans...   236   3e-60
gi|19112543|ref|NP_595751.1| putative permease [Schizosaccharomy...   235   4e-60
gi|15643057|ref|NP_228100.1| ABC transporter, ATP-binding protei...   235   4e-60
gi|16519755|ref|NP_443875.1| Y4gM [Rhizobium sp. NGR234] >gnl|BL...   235   4e-60
gi|23102360|ref|ZP_00088871.1| COG5265: ABC-type transport syste...   235   4e-60
gi|15674418|ref|NP_268592.1| putative ABC transporter (ATP-bindi...   235   5e-60
gi|22971761|ref|ZP_00018689.1| hypothetical protein [Chloroflexu...   235   5e-60
gi|33602079|ref|NP_889639.1| ABC transporter, ATP-binding protei...   235   5e-60
gi|13476485|ref|NP_108055.1| ABC transporter, ATP-binding protei...   235   5e-60
gi|45656478|ref|YP_000564.1| ABC transporter, atp-binding protei...   235   5e-60
gi|16552593|dbj|BAB71347.1| unnamed protein product [Homo sapiens]    234   6e-60
gi|49474872|ref|YP_032913.1| ABC transporter, ATP-binding protei...   234   6e-60
gi|3387977|gb|AAC28653.1| ABC transporter [Homo sapiens]              234   6e-60
gi|17230327|ref|NP_486875.1| ATP-binding protein; heterocyst dif...   234   6e-60
gi|15641880|ref|NP_231512.1| transport ATP-binding protein MsbA ...   234   6e-60
gi|11245444|gb|AAG33617.1| ATP-binding cassette half-transporter...   234   6e-60
gi|9955963|ref|NP_005680.1| ATP-binding cassette, sub-family B, ...   234   6e-60
gi|33592061|ref|NP_879705.1| ABC transporter, ATP-binding protei...   234   6e-60
gi|24216329|ref|NP_713810.1| Probable transport ATP-binding prot...   234   8e-60
gi|33597710|ref|NP_885353.1| putative ABC transporter [Bordetell...   234   8e-60
gi|23467052|ref|ZP_00122637.1| COG1132: ABC-type multidrug trans...   234   8e-60
gi|47572829|ref|ZP_00242870.1| COG1132: ABC-type multidrug trans...   234   8e-60
gi|27452473|gb|AAN71740.1| ABCB9-like TAP-family protein [Petrom...   234   8e-60
gi|29654183|ref|NP_819875.1| ABC transporter, ATP-binding/permea...   234   8e-60
gi|33596261|ref|NP_883904.1| ABC transporter, ATP-binding protei...   234   8e-60
gi|7445810|pir||S72638 hypothetical ABC exporter component B - T...   234   8e-60
gi|21909700|ref|NP_663968.1| putative ABC transporter ATP-bindin...   234   1e-59
gi|42527766|ref|NP_972864.1| ABC transporter, ATP-binding/permea...   234   1e-59
gi|48835452|ref|ZP_00292452.1| COG1132: ABC-type multidrug trans...   233   1e-59
gi|26246941|ref|NP_752981.1| Probable transport ATP-binding prot...   233   1e-59
gi|30519701|emb|CAD90041.1| putative ATP-binding cassette transp...   233   1e-59
gi|15888407|ref|NP_354088.1| AGR_C_1966p [Agrobacterium tumefaci...   233   2e-59
gi|15800775|ref|NP_286789.1| ATP-binding transport protein; mult...   233   2e-59
gi|47569984|ref|ZP_00240647.1| multidrug resistance ABC transpor...   233   2e-59
gi|17934971|ref|NP_531761.1| ABC transporter, nucleotide binding...   233   2e-59
gi|26788068|emb|CAD58764.1| SI:dZ179B20.3 (novel protein similar...   233   2e-59
gi|17647117|ref|NP_076221.1| ATP-binding cassette, sub-family B ...   233   2e-59
gi|17987775|ref|NP_540409.1| HEAVY METAL TOLERANCE PROTEIN PRECU...   233   2e-59
gi|23501343|ref|NP_697470.1| ABC transporter, ATP-binding/permea...   233   2e-59
gi|17561534|ref|NP_506927.1| HAlF transporter, PGP related (haf-...   232   3e-59
gi|28872098|ref|NP_794717.1| lipid A ABC transporter, ATP-bindin...   232   3e-59
gi|46396386|sp|Q87VF3|MSBA_PSESM Lipid A export ATP-binding/perm...   232   3e-59
gi|27381043|ref|NP_772572.1| ABC transporter HlyB/MsbA family [B...   232   3e-59
gi|37523704|ref|NP_927081.1| HlyB/MsbA family ABC transporter [G...   232   3e-59
gi|30020094|ref|NP_831725.1| Multidrug resistance ABC transporte...   232   3e-59
gi|42520276|ref|NP_966191.1| ABC transporter, HlyB/MsbA family, ...   232   3e-59
gi|19745369|ref|NP_606505.1| putative ABC transporter (ATP-bindi...   232   4e-59
gi|33861384|ref|NP_892945.1| ABC transporter, possibly multidrug...   231   5e-59
gi|2232172|gb|AAB62237.1| TAP2 [Oncorhynchus mykiss]                  231   5e-59
gi|7486813|pir||T05802 hypothetical protein M7J2.180 - Arabidops...   231   5e-59
gi|20808867|ref|NP_624038.1| ABC-type multidrug/protein/lipid tr...   231   5e-59
gi|50259844|gb|EAL22512.1| hypothetical protein CNBB3900 [Crypto...   231   7e-59
gi|22971760|ref|ZP_00018688.1| hypothetical protein [Chloroflexu...   231   7e-59
gi|16121675|ref|NP_404988.1| probable transport ATP-binding prot...   231   7e-59


>gi|17569143|ref|NP_509901.1| P-GlycoProtein related (pgp-3)
            [Caenorhabditis elegans]
 gi|29429184|sp|P34713|MDR3_CAEEL Multidrug resistance protein 3
            (P-glycoprotein C)
 gi|7511155|pir||T22094 hypothetical protein ZK455.7 - Caenorhabditis
            elegans
 gi|3877009|emb|CAA91467.1| Hypothetical protein ZK455.7
            [Caenorhabditis elegans]
 gi|3881645|emb|CAA91495.1| C. elegans PGP-3 protein (corresponding
            sequence ZK455.7) [Caenorhabditis elegans]
          Length = 1268

 Score = 1614 bits (4179), Expect = 0.0
 Identities = 835/879 (94%), Positives = 835/879 (94%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW
Sbjct: 390  ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 449

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG
Sbjct: 450  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 509

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
            AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI
Sbjct: 510  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 569

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
            AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERA
Sbjct: 570  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAKEDTTLDDEE 629

Query: 722  XXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXXXXGA 901
                HRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVP              GA
Sbjct: 630  DEKTHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPEWEIENAREEMIEEGA 689

Query: 902  MEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALL 1081
            MEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALL
Sbjct: 690  MEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALL 749

Query: 1082 NSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSL 1261
            NSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSL
Sbjct: 750  NSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSL 809

Query: 1262 TSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXXX 1441
            TSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIG
Sbjct: 810  TSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGLATALLLVVVQSS 869

Query: 1442 XXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVR 1621
               YLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVR
Sbjct: 870  VAQYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVR 929

Query: 1622 GLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAASY 1801
            GLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAASY
Sbjct: 930  GLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAASY 989

Query: 1802 FPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVLDG 1981
            FPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVLDG
Sbjct: 990  FPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVLDG 1049

Query: 1982 FNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIAL 2161
            FNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIAL
Sbjct: 1050 FNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIAL 1109

Query: 2162 VGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRLS 2341
            VGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRLS
Sbjct: 1110 VGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRLS 1169

Query: 2342 GGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTI 2521
            GGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTI
Sbjct: 1170 GGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTI 1229

Query: 2522 QNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
            QNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS
Sbjct: 1230 QNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 1268



 Score =  301 bits (771), Expect = 5e-80
 Identities = 191/592 (32%), Positives = 304/592 (51%), Gaps = 16/592 (2%)
 Frame = +2

Query: 905  EASLFDIFKYASPEMRNIII---SLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKA 1075
            + + FD+F+ A  + ++ I+    L+ + + G   P  S+++  +   L  G
Sbjct: 28   QGNFFDVFRDA--DYKDYILFSGGLILSAVNGALVPFNSLIFEGIANALMEGESQYQ-NG 84

Query: 1076 LLNSLWF-------ILLAFTGGISTLISGSLLGKAGETMSGR----LRMDVFRNIMQQDA 1222
             +N  WF        L  F  G++  +          T+  R    +R    +++++QDA
Sbjct: 85   TINMPWFSSEIKMFCLRYFYLGVALFLCSYFANSCLYTLCERRLHCIRKKYLKSVLRQDA 144

Query: 1223 SYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIG 1402
             +FD++   +G LT ++++    ++  I  ++  ++ G+ +   GV + FY  W +  +
Sbjct: 145  KWFDET--TIGGLTQKMSSGIEKIKDGIGDKVGVLVGGVATFISGVSIGFYMCWQLTLVM 202

Query: 1403 XXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFT 1582
                            +L    + +M +   A  +  E I+  +TV A   Q +  + +
Sbjct: 203  MITVPLQLGSMYLSAKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYA 262

Query: 1583 AASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEAL 1762
                   R  I + +  ++  A     +    A+A+ +G  L +    +   VF V  A+
Sbjct: 263  HQLNEARRMGIRKAIILAICTAFPLMLMFTCMAVAFWYGATLAAAGAVSSGAVFAVFWAV 322

Query: 1763 NMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVY 1939
             + +  +  AA +      AR++   +F +I  +  I      G  P  I+G +   G+
Sbjct: 323  LIGTRRLGEAAPHLGAITGARLAIHDIFKVIDHEPEIKCTSSEGKIPEKIQGKLTFDGIE 382

Query: 1940 FAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDI 2119
            F YP R    +L G +   N G+TVALVG SGCGKST+I L+ R+Y+   G +K+D   I
Sbjct: 383  FTYPTRPELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPI 442

Query: 2120 RDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPD 2299
            ++ +++ LR  I +V QEP +F  T+ ENI  G   IT   +E+A  +AN H F+  L D
Sbjct: 443  QEYNIRWLRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSD 502

Query: 2300 GYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARL 2479
             YDT +GA   +LSGGQKQRVAIARAIVR P+ILLLDEATSALDTESE++VQ ALDKA
Sbjct: 503  RYDTVIGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASE 562

Query: 2480 GRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLAR-RGLYYRLVEKQ 2632
            GRT + IAHRLSTI+NA KI+V   G   E GTH  L+++  G+Y  +V+ Q
Sbjct: 563  GRTTLCIAHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ 614


>gi|283552|pir||S27338 P-glycoprotein C - Caenorhabditis elegans
 gi|6811|emb|CAA46191.1| P-glycoprotein C [Caenorhabditis elegans]
          Length = 1254

 Score = 1578 bits (4085), Expect = 0.0
 Identities = 821/879 (93%), Positives = 821/879 (93%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW
Sbjct: 390  ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 449

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG
Sbjct: 450  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 509

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
            AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI
Sbjct: 510  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 569

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
            AHRLSTIRNAS              THDELISKDDGIYASMVKAQEIERA
Sbjct: 570  AHRLSTIRNAS--------------THDELISKDDGIYASMVKAQEIERAKEDTTLDDEE 615

Query: 722  XXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXXXXGA 901
                HRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVP              GA
Sbjct: 616  DEKTHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPEWEIENAREEMIEEGA 675

Query: 902  MEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALL 1081
            MEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALL
Sbjct: 676  MEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALL 735

Query: 1082 NSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSL 1261
            NSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSL
Sbjct: 736  NSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSL 795

Query: 1262 TSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXXX 1441
            TSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIG
Sbjct: 796  TSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGLATELLLVVVQSS 855

Query: 1442 XXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVR 1621
               YLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVR
Sbjct: 856  VAQYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVR 915

Query: 1622 GLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAASY 1801
            GLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAASY
Sbjct: 916  GLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAASY 975

Query: 1802 FPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVLDG 1981
            FPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVLDG
Sbjct: 976  FPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVLDG 1035

Query: 1982 FNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIAL 2161
            FNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIAL
Sbjct: 1036 FNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIAL 1095

Query: 2162 VGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRLS 2341
            VGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRLS
Sbjct: 1096 VGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRLS 1155

Query: 2342 GGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTI 2521
            GGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTI
Sbjct: 1156 GGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTI 1215

Query: 2522 QNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
            QNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS
Sbjct: 1216 QNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 1254



 Score =  282 bits (722), Expect = 3e-74
 Identities = 185/592 (31%), Positives = 297/592 (49%), Gaps = 16/592 (2%)
 Frame = +2

Query: 905  EASLFDIFKYASPEMRNIII---SLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKA 1075
            + + FD+F+ A  + ++ I+    L+ + + G   P  S+++  +   L  G
Sbjct: 28   QGNFFDVFRDA--DYKDYILFSGGLILSAVNGALVPFNSLIFEGIANALMEGESQYQ-NG 84

Query: 1076 LLNSLWF-------ILLAFTGGISTLISGSLLGKAGETMSGR----LRMDVFRNIMQQDA 1222
             +N  WF        L  F  G++  +          T+  R    +R    +++++QDA
Sbjct: 85   TINMPWFSSEIKMFCLRYFYLGVALFLCSYFANSCLYTLCERRLHCIRKKYLKSVLRQDA 144

Query: 1223 SYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIG 1402
             +FD++   +G LT ++++    ++  I  ++  ++ G+ +   GV + FY  W +  +
Sbjct: 145  KWFDET--TIGGLTQKMSSGIEKIKDGIGDKVGVLVGGVATFISGVSIGFYMCWQLTLVM 202

Query: 1403 XXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFT 1582
                            +L    + +M +   A  +  E I+  +TV A   Q +  + +
Sbjct: 203  MITVPLQLGSMYLSAKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYA 262

Query: 1583 AASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEAL 1762
                   R  I + +  ++  A     +    A+A+ +G  L +    +   VF V  A+
Sbjct: 263  HQLNEARRMGIRKAIILAICTAFPLMLMFTCMAVAFWYGATLAAAGAVSSGAVFAVFWAV 322

Query: 1763 NMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVY 1939
             + +  +  AA +      AR++   +F +I  +  I      G  P  I+G +   G+
Sbjct: 323  LIGTRRLGEAAPHLGAITGARLAIHDIFKVIDHEPEIKCTSSEGKIPEKIQGKLTFDGIE 382

Query: 1940 FAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDI 2119
            F YP R    +L G +   N G+TVALVG SGCGKST+I L+ R+Y+   G +K+D   I
Sbjct: 383  FTYPTRPELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPI 442

Query: 2120 RDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPD 2299
            ++ +++ LR  I +V QEP +F  T+ ENI  G   IT   +E+A  +AN H F+  L D
Sbjct: 443  QEYNIRWLRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSD 502

Query: 2300 GYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARL 2479
             YDT +GA   +LSGGQKQRVAIARAIVR P+ILLLDEATSALDTESE++VQ ALDKA
Sbjct: 503  RYDTVIGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASE 562

Query: 2480 GRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLAR-RGLYYRLVEKQ 2632
            GRT + IAHRLSTI+NA               TH  L+++  G+Y  +V+ Q
Sbjct: 563  GRTTLCIAHRLSTIRNA--------------STHDELISKDDGIYASMVKAQ 600


>gi|39594784|emb|CAE70652.1| Hypothetical protein CBG17357
            [Caenorhabditis briggsae]
          Length = 1268

 Score = 1514 bits (3921), Expect = 0.0
 Identities = 776/879 (88%), Positives = 810/879 (91%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            +LKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQ AGMIKLDG+PI EYNIRW
Sbjct: 390  DLKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQGAGMIKLDGVPIHEYNIRW 449

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LRSTIGIVQQEPIIFVATVAENIRMGD LITD DIEEAC+MANAHEFICKLSD+Y+TVIG
Sbjct: 450  LRSTIGIVQQEPIIFVATVAENIRMGDDLITDDDIEEACRMANAHEFICKLSDKYNTVIG 509

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
            AGAVQLSGGQKQRVAIARAIVR+PQILLLDEATSALDTESERMVQ ALDKAS+GRTTLCI
Sbjct: 510  AGAVQLSGGQKQRVAIARAIVRRPQILLLDEATSALDTESERMVQAALDKASKGRTTLCI 569

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
            AHRLSTI+NASKILVFDQGLIAERGTHDELISK+DGIYASMV AQEIERA
Sbjct: 570  AHRLSTIKNASKILVFDQGLIAERGTHDELISKEDGIYASMVAAQEIERAKEDTTLDDEE 629

Query: 722  XXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXXXXGA 901
                HR FHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVP              GA
Sbjct: 630  DEKDHRMFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPEWEIESAREEMIEEGA 689

Query: 902  MEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALL 1081
            MEASL DIFK+ASPE RNIII+LVFTLIRG TWPAFSIVYGQLF+ILSAGGDDVSIKALL
Sbjct: 690  MEASLVDIFKFASPEGRNIIIALVFTLIRGLTWPAFSIVYGQLFRILSAGGDDVSIKALL 749

Query: 1082 NSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSL 1261
            NSLWF+LLAFT GISTL+SG LLGKAGETMSGRLRMDVFRNIMQQDASYFDD +HNVG+L
Sbjct: 750  NSLWFLLLAFTSGISTLVSGGLLGKAGETMSGRLRMDVFRNIMQQDASYFDDPKHNVGAL 809

Query: 1262 TSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXXX 1441
            TSRLATDAPNVQAAIDQRLAEVLTG+VSLFCGV VAF+YGWNMAPIG
Sbjct: 810  TSRLATDAPNVQAAIDQRLAEVLTGVVSLFCGVSVAFFYGWNMAPIGLATALLLVVVQSA 869

Query: 1442 XXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVR 1621
               YLKFRGQRDMDSAIEASRLVTESISNWKTVQ+LTKQEYMYD+F AASKSPHRRAIVR
Sbjct: 870  VAQYLKFRGQRDMDSAIEASRLVTESISNWKTVQSLTKQEYMYDSFVAASKSPHRRAIVR 929

Query: 1622 GLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAASY 1801
            GLWQSLSFALAGSFVMWNFAIAYMFGLWLISN WSTPYTVFQVIEALNMASMSVMLAASY
Sbjct: 930  GLWQSLSFALAGSFVMWNFAIAYMFGLWLISNGWSTPYTVFQVIEALNMASMSVMLAASY 989

Query: 1802 FPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVLDG 1981
            FPEYVRARISAGIMFTMIRQ+SVIDNRGLTGDTP IKG+I+MR VYFAYPNRRRQLVLD
Sbjct: 990  FPEYVRARISAGIMFTMIRQRSVIDNRGLTGDTPPIKGDISMREVYFAYPNRRRQLVLDS 1049

Query: 1982 FNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIAL 2161
            FNM+A FGQTVALVGPSGCGKSTTIQLIERYYDAL G +K+D  DIR++SVKHLRDNIAL
Sbjct: 1050 FNMTAKFGQTVALVGPSGCGKSTTIQLIERYYDALSGKIKVDGCDIREISVKHLRDNIAL 1109

Query: 2162 VGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRLS 2341
            VGQEPTLFNLTIRENITYGLE I+Q++VEKAATLANIHTFVMGLP+GYDTSVGASGGRLS
Sbjct: 1110 VGQEPTLFNLTIRENITYGLEKISQEEVEKAATLANIHTFVMGLPEGYDTSVGASGGRLS 1169

Query: 2342 GGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTI 2521
            GGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTC+VIAHRLSTI
Sbjct: 1170 GGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCIVIAHRLSTI 1229

Query: 2522 QNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
            QNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS+
Sbjct: 1230 QNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQST 1268



 Score =  300 bits (767), Expect = 2e-79
 Identities = 187/590 (31%), Positives = 304/590 (50%), Gaps = 14/590 (2%)
 Frame = +2

Query: 905  EASLFDIFKYASPEMRNIIIS-LVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALL 1081
            + + FD+F+ +      ++   ++ + + G   P  S+++  +   L  G         L
Sbjct: 28   QGNFFDVFRDSDWRDYALVAGGIILSAVNGALVPFNSLIFEGIANALMEGEAQYQ-NGTL 86

Query: 1082 NSLWF-------ILLAFTGGISTLISGSLLGKAGETMSGR----LRMDVFRNIMQQDASY 1228
            N  WF        L  F  G++  +          T+  R    +R    +++++QDA +
Sbjct: 87   NMPWFSSEIKFFCLRYFYLGLALFLCSYCANACLYTLCERRLHCIRKHYLKSVLRQDAKW 146

Query: 1229 FDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXX 1408
            FD  +H +G LT ++++    ++  I  ++  ++ G+ +   GV + FY  W +  +
Sbjct: 147  FD--QHTIGGLTQKMSSGIEKIKDGIGDKIGVIVGGVATFISGVSLGFYMCWQLTLVMLI 204

Query: 1409 XXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAA 1588
                          +L    + +M +   A  +  E I+  +TV A   Q +  + ++
Sbjct: 205  TVPLQLGSMYLSAKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYSQQ 264

Query: 1589 SKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNM 1768
             +   +  + + +  ++  +     +    A+A+ +G  L +    +   VF V  A+ +
Sbjct: 265  LEEARKMGVRKAMILAICTSFPLMLMFTCMAVAFWYGATLAAAGAVSSGAVFAVFWAVLI 324

Query: 1769 ASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFA 1945
             +  +  AA +      AR++   +F +I  +  I      G  P  I+G ++  G+ F
Sbjct: 325  GTRRIGEAAPHLGAITGARLAIHDIFKVIDHEPEIKCTSSDGKIPDKIQGKLSFDGIEFT 384

Query: 1946 YPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRD 2125
            YP R    +L G +   N G+TVALVG SGCGKST+I L+ R+Y+   G +K+D   I +
Sbjct: 385  YPTRPDLKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQGAGMIKLDGVPIHE 444

Query: 2126 LSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGY 2305
             +++ LR  I +V QEP +F  T+ ENI  G + IT D +E+A  +AN H F+  L D Y
Sbjct: 445  YNIRWLRSTIGIVQQEPIIFVATVAENIRMGDDLITDDDIEEACRMANAHEFICKLSDKY 504

Query: 2306 DTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGR 2485
            +T +GA   +LSGGQKQRVAIARAIVR P+ILLLDEATSALDTESE++VQ ALDKA  GR
Sbjct: 505  NTVIGAGAVQLSGGQKQRVAIARAIVRRPQILLLDEATSALDTESERMVQAALDKASKGR 564

Query: 2486 TCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARR-GLYYRLVEKQ 2632
            T + IAHRLSTI+NA KI+V   G   E GTH  L+++  G+Y  +V  Q
Sbjct: 565  TTLCIAHRLSTIKNASKILVFDQGLIAERGTHDELISKEDGIYASMVAAQ 614


>gi|39594783|emb|CAE70651.1| Hypothetical protein CBG17356
            [Caenorhabditis briggsae]
          Length = 1265

 Score = 1365 bits (3534), Expect = 0.0
 Identities = 685/879 (77%), Positives = 773/879 (87%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            ++KILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAG IKLDG+PI++YNI+W
Sbjct: 388  DVKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGTIKLDGVPIEDYNIQW 447

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LRSTIGIVQQEPIIF+ATV+ENIRMGD  ITD+DIE+AC+ ANAH+FI  LSD Y+T+IG
Sbjct: 448  LRSTIGIVQQEPIIFLATVSENIRMGDNSITDKDIEDACRQANAHDFIGHLSDGYNTIIG 507

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
            AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQ ALDKAS+GRTTLCI
Sbjct: 508  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQAALDKASQGRTTLCI 567

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
            AHRLSTIRNA+KILVFDQGLI E+GTHD+LI + +GIYASMV+AQEIERA
Sbjct: 568  AHRLSTIRNANKILVFDQGLIVEKGTHDQLI-RQNGIYASMVRAQEIERAKEDTVVEDDS 626

Query: 722  XXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXXXXGA 901
                 +S  R   TS++E    +SL RDS RL QSM+S T+QVP              GA
Sbjct: 627  LEEETQSISRRLSTSEDEVRKSKSLLRDSARLSQSMLSVTSQVPDWEVEIAREEMFEEGA 686

Query: 902  MEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALL 1081
            MEAS+ DIF++A PE  N+II+L+ TLIRG TWPAFS+VYGQLFK+ + GG+D+   A +
Sbjct: 687  MEASMMDIFRFAKPEKWNVIIALIVTLIRGITWPAFSVVYGQLFKVFAEGGEDLPTNAFV 746

Query: 1082 NSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSL 1261
            +SLWFILLAFT GI+T ISGSLLGK GETMS RLR++VF+NIMQQDASYFD+ +HNVG+L
Sbjct: 747  SSLWFILLAFTSGITTFISGSLLGKTGETMSSRLRLNVFKNIMQQDASYFDEPKHNVGNL 806

Query: 1262 TSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXXX 1441
            T+RLATD+ NVQAAID RLAEVL G++SLF G+ VAF++GW+MAPIG
Sbjct: 807  TARLATDSQNVQAAIDHRLAEVLNGVISLFAGIAVAFWFGWSMAPIGLLTALLLVIAQSS 866

Query: 1442 XXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVR 1621
               YLK+RG +DM+SAIEASR+VTESISNWKTVQALTKQEYMY AFT ASK P +RA  +
Sbjct: 867  VAQYLKYRGPKDMESAIEASRIVTESISNWKTVQALTKQEYMYGAFTTASKKPRQRAFAK 926

Query: 1622 GLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAASY 1801
            GLWQSLSFALAGSF +WNFAIAYMFGLWLISNNW+TP+ VFQVIEALNMASMSVM+AASY
Sbjct: 927  GLWQSLSFALAGSFFLWNFAIAYMFGLWLISNNWTTPFAVFQVIEALNMASMSVMMAASY 986

Query: 1802 FPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVLDG 1981
            FPEYVRARISAGIMFTMIRQKS IDNRGLTG+TP IKG+I+MRGVYFAYPNR+RQL+L+
Sbjct: 987  FPEYVRARISAGIMFTMIRQKSAIDNRGLTGETPLIKGDISMRGVYFAYPNRKRQLILNN 1046

Query: 1982 FNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIAL 2161
            FNMSANFGQTVALVGPSGCGKSTTIQLIERYYDA+CGSV+IDD+D+RD+SVKHLRDNIAL
Sbjct: 1047 FNMSANFGQTVALVGPSGCGKSTTIQLIERYYDAVCGSVRIDDTDVRDISVKHLRDNIAL 1106

Query: 2162 VGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRLS 2341
            VGQEPTLFNL+IRENITYGLEN++Q+Q+E+AA LANIH FV+ LP+GYDTSVGASGGRLS
Sbjct: 1107 VGQEPTLFNLSIRENITYGLENVSQEQIEEAAKLANIHNFVISLPEGYDTSVGASGGRLS 1166

Query: 2342 GGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTI 2521
            GGQKQR+AIARAIVRDPKILLLDEATSALD+ESEKIVQEALDKARLGRTCVVIAHRLSTI
Sbjct: 1167 GGQKQRIAIARAIVRDPKILLLDEATSALDSESEKIVQEALDKARLGRTCVVIAHRLSTI 1226

Query: 2522 QNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
            QNADKIIVCRNGKAIEEGTHQ+LLARRGLYYRLVEKQS+
Sbjct: 1227 QNADKIIVCRNGKAIEEGTHQSLLARRGLYYRLVEKQST 1265



 Score =  306 bits (784), Expect = 2e-81
 Identities = 203/590 (34%), Positives = 310/590 (52%), Gaps = 16/590 (2%)
 Frame = +2

Query: 911  SLFDIFKYASP-EMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGG----------D 1057
            SL ++F+++   +   ++  +VF+   G   P  S+++  +  +L  G           D
Sbjct: 28   SLSNLFRHSDCLDYLLLLGGIVFSSASGALLPFNSLIFEGITNVLMQGQSEWQNGTFAYD 87

Query: 1058 DVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDD 1237
              S       L + LL     + T IS + L    E     +R  + R++++QDA +FD+
Sbjct: 88   TFSTGIRHYCLLYFLLGVFMFLCTYISNACLYTMAERRLYCIRKHLLRSVLRQDAQWFDE 147

Query: 1238 SRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXX 1417
            +   VG LT ++++    ++  I  ++  + +G  +   GV + FY  W +  +
Sbjct: 148  N--TVGGLTQKMSSGIEKIKDGIGDKIGVLFSGAATFISGVLLGFYMCWQLTLVMLITVP 205

Query: 1418 XXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMY----DAFTA 1585
                       +L    + +M +   A  +  E I+  +TV A   Q +      D
Sbjct: 206  LQLGQMYMSAKHLNRATKNEMSAYSSAGGMANEVIAGIRTVIAFNAQPFEISRYADKLAE 265

Query: 1586 ASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALN 1765
            A +   R++IV     ++   L   FV+   A A+ +G  L S   +T  T F V  A+
Sbjct: 266  ARQMGIRKSIVLASCSAVPLVLM--FVL--MAGAFWYGAILTSFGIATSGTTFGVFWAVL 321

Query: 1766 MASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYF 1942
            + +  +  AA +    + AR++   +F +I  +  I+    TG  P  I G +N   + F
Sbjct: 322  LGTRRLGEAAPHMGAILGARLAINDIFKVIDNEPEINCTKETGRRPEKINGKLNFDNIEF 381

Query: 1943 AYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIR 2122
             YP R    +L G +   N G+TVALVG SGCGKST+I L+ R+Y+   G++K+D   I
Sbjct: 382  TYPTRPDVKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGTIKLDGVPIE 441

Query: 2123 DLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDG 2302
            D +++ LR  I +V QEP +F  T+ ENI  G  +IT   +E A   AN H F+  L DG
Sbjct: 442  DYNIQWLRSTIGIVQQEPIIFLATVSENIRMGDNSITDKDIEDACRQANAHDFIGHLSDG 501

Query: 2303 YDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLG 2482
            Y+T +GA   +LSGGQKQRVAIARAIVR P+ILLLDEATSALDTESE++VQ ALDKA  G
Sbjct: 502  YNTIIGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQAALDKASQG 561

Query: 2483 RTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
            RT + IAHRLSTI+NA+KI+V   G  +E+GTH  L+ + G+Y  +V  Q
Sbjct: 562  RTTLCIAHRLSTIRNANKILVFDQGLIVEKGTHDQLIRQNGIYASMVRAQ 611


>gi|17569145|ref|NP_509902.1| P-GlycoProtein related (pgp-4)
            [Caenorhabditis elegans]
 gi|7503247|pir||T22090 hypothetical protein F42E11.1 - Caenorhabditis
            elegans
 gi|3877005|emb|CAA91463.1| Hypothetical protein F42E11.1
            [Caenorhabditis elegans]
          Length = 1266

 Score = 1365 bits (3532), Expect = 0.0
 Identities = 689/880 (78%), Positives = 772/880 (87%), Gaps = 1/880 (0%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            ++KILKGVSFEVNPGET+ALVGHSGCGKSTSIGLLMRFYNQCAG IKLDGIPI++YNI+W
Sbjct: 388  DVKILKGVSFEVNPGETIALVGHSGCGKSTSIGLLMRFYNQCAGSIKLDGIPIEDYNIQW 447

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LRSTIGIVQQEPIIF+ATVAEN+RMGD  ITD+DIE AC+ ANAH+FI KLS+ Y+TVIG
Sbjct: 448  LRSTIGIVQQEPIIFLATVAENVRMGDDSITDKDIENACRQANAHDFIGKLSEGYNTVIG 507

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
            AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI
Sbjct: 508  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 567

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
            AHRLSTIRNASKILVFDQGLI ERG HD+LI + +GIYA+MV+AQEIE+A
Sbjct: 568  AHRLSTIRNASKILVFDQGLIPERGIHDQLI-RQNGIYANMVRAQEIEKAKDDTTQDDDE 626

Query: 722  XXXXHR-SFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXXXXG 898
                   S  R   TS+EE    +SL RDSTR  QSM+S T+QVP              G
Sbjct: 627  LVEEDNYSISRRLSTSEEELRKSKSLLRDSTRFSQSMLSVTSQVPDWEMESAREEMIEEG 686

Query: 899  AMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKAL 1078
            AMEAS+ DIF++A PE  NI+I+L+FTLIRG TWPAFS+VYGQLFK+ + GG+D+ + AL
Sbjct: 687  AMEASMMDIFRFAKPEKMNIVIALIFTLIRGITWPAFSVVYGQLFKVFAEGGEDLPVNAL 746

Query: 1079 LNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGS 1258
            ++SLWF+LLA T  ++T ISGSLLGK GETMS RLRMDVF+NIMQQDA+YFDD +HNVG+
Sbjct: 747  ISSLWFVLLAVTSAVTTFISGSLLGKTGETMSSRLRMDVFKNIMQQDATYFDDPKHNVGN 806

Query: 1259 LTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXX 1438
            LTSRLATD+ NVQAAID RLAEVL G+VSLF G+ VAF++GW+MAPIG
Sbjct: 807  LTSRLATDSQNVQAAIDHRLAEVLNGVVSLFTGIAVAFWFGWSMAPIGLITALLLVIAQS 866

Query: 1439 XXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIV 1618
                YLK+RG +DM+SAIEASR+VTESISNWKTVQALTKQEYM+ AFTAASK+P +RA
Sbjct: 867  AVAQYLKYRGPKDMESAIEASRIVTESISNWKTVQALTKQEYMFHAFTAASKNPRKRAFT 926

Query: 1619 RGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAAS 1798
            +GLWQSLSFALAGSF +WNFAIAYMFGLWLISNNW+TP+ VFQVIEALNMASMSVM+AAS
Sbjct: 927  KGLWQSLSFALAGSFFLWNFAIAYMFGLWLISNNWTTPFAVFQVIEALNMASMSVMMAAS 986

Query: 1799 YFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVLD 1978
            YFPEYVRARISAGIMFTMIRQK+ IDNRGLTG+TP I+G+I+M+GVYFAYPNR RQL+L+
Sbjct: 987  YFPEYVRARISAGIMFTMIRQKAKIDNRGLTGETPDIRGDISMKGVYFAYPNRNRQLILN 1046

Query: 1979 GFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIA 2158
             FNMSA FG+TVALVGPSGCGKST+IQLIERYYDA+CG+VKIDD DIRD+SVKHLR NIA
Sbjct: 1047 NFNMSAQFGETVALVGPSGCGKSTSIQLIERYYDAICGAVKIDDHDIRDISVKHLRHNIA 1106

Query: 2159 LVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRL 2338
            LVGQEPTLFNLTIRENITYGLEN++Q+QVEKAATLANIH+FV  LP+GYDTSVGASGGRL
Sbjct: 1107 LVGQEPTLFNLTIRENITYGLENVSQEQVEKAATLANIHSFVENLPEGYDTSVGASGGRL 1166

Query: 2339 SGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLST 2518
            SGGQKQR+AIARAIVR+PKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLST
Sbjct: 1167 SGGQKQRIAIARAIVRNPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLST 1226

Query: 2519 IQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
            IQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS+
Sbjct: 1227 IQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQST 1266



 Score =  301 bits (771), Expect = 5e-80
 Identities = 199/590 (33%), Positives = 306/590 (51%), Gaps = 16/590 (2%)
 Frame = +2

Query: 911  SLFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGG----------D 1057
            SL ++F+++   +   ++  LV +   G   P  S+++  +  +L  G           D
Sbjct: 28   SLSNLFRHSGCADYLLLLGGLVLSAANGALLPFNSLIFEGITNVLMKGEAQWQNGTFDYD 87

Query: 1058 DVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDD 1237
              S       L + LL       T  S + L    E     +R  + +++++QDA +FD+
Sbjct: 88   TFSSGIQHYCLLYFLLGVLMFTCTYFSNACLFTMAERRLYCIRKHLLQSVLRQDAKWFDE 147

Query: 1238 SRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXX 1417
            +   VG LT ++++    ++  I  ++  +++GI +   GV + FY  W +  +
Sbjct: 148  N--TVGGLTQKMSSGIEKIKDGIGDKIGVLVSGIATFISGVALGFYMCWQLTLVMLVTVP 205

Query: 1418 XXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTA---- 1585
                       +L    + +M +   A  +  E I+  +TV A   Q +  + + A
Sbjct: 206  LQLGSMYLSAKHLNRATKNEMSAYSSAGGMANEVIAGIRTVIAFNAQPFEIERYGAQLAK 265

Query: 1586 ASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALN 1765
            A K   R+AIV  L  ++   L   FV+   A A+ +G  L S   +T  T F V  A+
Sbjct: 266  ARKMGIRKAIVLALCSAMPLFLM--FVL--MAGAFWYGAILTSYGVATSGTTFGVFWAVI 321

Query: 1766 MASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYF 1942
            + +  +  AA +      AR++   +F +I  +  I+     G  P  + G +    + F
Sbjct: 322  LGTRRLGEAAPHMGAITGARLAVNDIFKVIDHEPEINCTKQEGRRPDKVNGKLVFDNIQF 381

Query: 1943 AYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIR 2122
             YP R    +L G +   N G+T+ALVG SGCGKST+I L+ R+Y+   GS+K+D   I
Sbjct: 382  TYPTRPDVKILKGVSFEVNPGETIALVGHSGCGKSTSIGLLMRFYNQCAGSIKLDGIPIE 441

Query: 2123 DLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDG 2302
            D +++ LR  I +V QEP +F  T+ EN+  G ++IT   +E A   AN H F+  L +G
Sbjct: 442  DYNIQWLRSTIGIVQQEPIIFLATVAENVRMGDDSITDKDIENACRQANAHDFIGKLSEG 501

Query: 2303 YDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLG 2482
            Y+T +GA   +LSGGQKQRVAIARAIVR P+ILLLDEATSALDTESE++VQ ALDKA  G
Sbjct: 502  YNTVIGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEG 561

Query: 2483 RTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
            RT + IAHRLSTI+NA KI+V   G   E G H  L+ + G+Y  +V  Q
Sbjct: 562  RTTLCIAHRLSTIRNASKILVFDQGLIPERGIHDQLIRQNGIYANMVRAQ 611


>gi|39595964|emb|CAE67467.1| Hypothetical protein CBG12969
            [Caenorhabditis briggsae]
          Length = 1231

 Score =  753 bits (1943), Expect = 0.0
 Identities = 395/850 (46%), Positives = 562/850 (65%), Gaps = 2/850 (0%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            ++ +LKG+S   NPGE +ALVGHSG GKST+  L+M FY    G I +D   I E N+
Sbjct: 392  KVNVLKGISLHANPGENIALVGHSGSGKSTTAALMMHFYELNGGKISIDDTNIDELNLSH 451

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR+ +GIV QEP++F  TV  N+R+G   + D ++E  CK+ANAH+FI +L + Y T IG
Sbjct: 452  LRNIVGIVSQEPLLFADTVENNMRLGAPDLDDNEMEYYCKLANAHDFIEQLPNGYKTAIG 511

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
             G V+LSGGQ+QR+AIAR + RKP IL+LDEATSALD+ESE +VQ AL+ A+EGRTT+ I
Sbjct: 512  NGGVELSGGQRQRIAIARTLARKPSILILDEATSALDSESESLVQIALENAAEGRTTITI 571

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
            AHRL TIRN ++I VFD G I E G+H EL+ KD G YA MV++QEIE
Sbjct: 572  AHRLGTIRNCNRIYVFDDGKIVEVGSHQELMEKD-GHYAKMVQSQEIEVGNRQESTMEEY 630

Query: 722  XXXXHRSFHRDSVTSDEERE-LQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXXXXG 898
                 R    +S  S   R+   +  AR  +   + ++S  + +P
Sbjct: 631  SFESRR----ESCDSKSSRQKFSKKTARSCSLTSEKLLSDISPLPIGEE----------N 676

Query: 899  AMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV-SIKA 1075
               ++  +I +Y  PE   + IS++ +++RGF +P +SI+YG++F+ILS G D+  S  +
Sbjct: 677  EQPSTFLEILRYTKPEWGLLAISILISVLRGFNYPIYSILYGRMFRILSTGTDEEKSSNS 736

Query: 1076 LLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVG 1255
             +N+++   L     I T+ +G L+G  GE ++ RLR+ +F NI++QD  YFD   H  G
Sbjct: 737  GMNAIYLTALGIYALIVTMAAGCLIGYVGERLTKRLRILLFTNILRQDGEYFDVPEHAPG 796

Query: 1256 SLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXX 1435
             L +RL+TDAPN++AAIDQRLA+V+ G  ++FCG+ +AF++   MA +G
Sbjct: 797  RLITRLSTDAPNIRAAIDQRLADVIQGFSAVFCGIAIAFWFSPTMALMGLVNVGVLISLQ 856

Query: 1436 XXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAI 1615
                  LK RG++D + + E SRL  E++   +TVQ LT+++     F       H R +
Sbjct: 857  GFITHVLKKRGEKDSERSEEPSRLAIEAVEQHRTVQYLTREQSFVKKFADGMHPIHIRNL 916

Query: 1616 VRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAA 1795
             RG+ QS+S+AL+ S+  ++FAI Y FGL L+ ++ + P+TVFQVIE+LN +S S++
Sbjct: 917  QRGILQSISYALSTSYTSFSFAIGYRFGLLLVDHDLANPFTVFQVIESLNSSSPSLLALG 976

Query: 1796 SYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVL 1975
            SY PE+VRA+ISAG++F M+R +  ID+   TG   T+  +I+++ VYF Y    R+++L
Sbjct: 977  SYIPEFVRAQISAGLLFQMLRYEPKIDSN--TGKKTTLDSDISLKNVYFGYQVSGRKMIL 1034

Query: 1976 DGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNI 2155
              F +    G+T A+VG SGCGKSTTIQL+ER+YD + G +    +++RDL++KHLR  +
Sbjct: 1035 KDFTLKIESGKTTAIVGASGCGKSTTIQLLERFYDPIAGRIDFGSTNLRDLNLKHLRSQV 1094

Query: 2156 ALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGR 2335
            ALV QEPTLFN +IR+NI YGLE+I + +V +AA +A+ H F+  LP+GYDT VG  G +
Sbjct: 1095 ALVEQEPTLFNYSIRKNIAYGLESIKEGEVIQAAKIAHAHEFITSLPEGYDTIVGEGGSK 1154

Query: 2336 LSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLS 2515
            LSGGQKQR+AIARAIVR+PKILLLDEA SALD ESE++VQEAL+KA+ GRTCVVIAHRL+
Sbjct: 1155 LSGGQKQRIAIARAIVRNPKILLLDEAMSALDVESERLVQEALEKAKEGRTCVVIAHRLT 1214

Query: 2516 TIQNADKIIV 2545
            TI+ A  I++
Sbjct: 1215 TIRGALLILI 1224



 Score =  263 bits (673), Expect = 1e-68
 Identities = 160/492 (32%), Positives = 261/492 (52%), Gaps = 7/492 (1%)
 Frame = +2

Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
            ++R+  F  +++QD  +FD  +++ G+   R+      V+  +  +L  ++  +   FCG
Sbjct: 131  KIRVAYFSALLRQDWEWFD--QNDSGAAIVRMNDGLERVRDGLGDKLGVIIAYLTHFFCG 188

Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
            + +AFY    M  +                  +     +++++   A+    E IS  KT
Sbjct: 189  LSLAFYLSVEMTIVTLIITPAFILPIIISRKMISKVTFKELEAYESAATAAGEVISGIKT 248

Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSF------VMWNFAIAYMFG 1699
            V +   ++   + ++        +A+  GLW++   +  G          W F   + +G
Sbjct: 249  VVSFNGEQKEINRYSKFLS----KAMYWGLWRASLSSFEGLLGHSSCVFQWQFHSGW-WG 303

Query: 1700 LWLISNNWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDN 1879
              L+     TP T   V  A+N A   V  A  +         +A  +F +I +  ++D
Sbjct: 304  TRLVLKGSITPGTTLAVFWAVNGAIYFVGQAIPHLTSVSSCYSAAVPVFQIIDRTVILDG 363

Query: 1880 RGLTG-DTPTIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTI 2056
                G     +KG +    V+F YP R++  VL G ++ AN G+ +ALVG SG GKSTT
Sbjct: 364  TSDKGLKLSKVKGKVKFENVWFKYPARQKVNVLKGISLHANPGENIALVGHSGSGKSTTA 423

Query: 2057 QLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQ 2236
             L+  +Y+   G + IDD++I +L++ HLR+ + +V QEP LF  T+  N+  G  ++
Sbjct: 424  ALMMHFYELNGGKISIDDTNIDELNLSHLRNIVGIVSQEPLLFADTVENNMRLGAPDLDD 483

Query: 2237 DQVEKAATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEA 2416
            +++E    LAN H F+  LP+GY T++G  G  LSGGQ+QR+AIAR + R P IL+LDEA
Sbjct: 484  NEMEYYCKLANAHDFIEQLPNGYKTAIGNGGVELSGGQRQRIAIARTLARKPSILILDEA 543

Query: 2417 TSALDTESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLA 2596
            TSALD+ESE +VQ AL+ A  GRT + IAHRL TI+N ++I V  +GK +E G+HQ L+
Sbjct: 544  TSALDSESESLVQIALENAAEGRTTITIAHRLGTIRNCNRIYVFDDGKIVEVGSHQELME 603

Query: 2597 RRGLYYRLVEKQ 2632
            + G Y ++V+ Q
Sbjct: 604  KDGHYAKMVQSQ 615


>gi|17558664|ref|NP_507487.1| P-GlycoProtein related (pgp-9)
            [Caenorhabditis elegans]
 gi|7497530|pir||T19982 hypothetical protein C47A10.1 - Caenorhabditis
            elegans
 gi|3875004|emb|CAB03973.1| Hypothetical protein C47A10.1
            [Caenorhabditis elegans]
 gi|3879215|emb|CAB07855.1| Hypothetical protein C47A10.1
            [Caenorhabditis elegans]
          Length = 1294

 Score =  732 bits (1890), Expect = 0.0
 Identities = 401/895 (44%), Positives = 560/895 (61%), Gaps = 16/895 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            ++KILKGVS +  PG+TVALVG SGCGKST I LL RFYN  AG I +D IPI+++NI++
Sbjct: 397  DVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKY 456

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  +G+V QEP +F  ++ +NIR G   ++D+DI  A K ANA +FI    +  +T++G
Sbjct: 457  LRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNTLVG 516

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
               VQ+SGGQKQR+AIARA+VR P+ILLLDEATSALD ESE +VQ+AL+ AS GRTT+ I
Sbjct: 517  DRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENASRGRTTIVI 576

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
            AHRLST+RNA KI+V   G + E GTH+ LI +  G+Y  +V AQ
Sbjct: 577  AHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQK-GLYHELVHAQVFADVDDKPKKKEAE 635

Query: 722  XXXXHRSFHRDSVTSDEERELQ-----------QSLARDSTRLRQSMISTTTQVPXXXXX 868
                 ++  R    + + +E Q           ++  ++  RL++ +
Sbjct: 636  RRMSRQTSQRKGSVNFKTQESQVDEKPGAPPAPEAAEKEIKRLKKEL------------- 682

Query: 869  XXXXXXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILS- 1045
                     GA++A+LF I +YA PE   I  +++  LI+G   PAFS+ + Q+  + S
Sbjct: 683  ------EEEGAVKANLFKILRYARPEWIYIFFAIIAALIQGAVMPAFSLFFSQIINVFSN 736

Query: 1046 AGGDDVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDAS 1225
               D +       +L F++LA   G S L   SL G A E ++ R+R  V+RN+++QDA+
Sbjct: 737  PDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDAT 796

Query: 1226 YFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGX 1405
            YFD  +H+ G +T+RLATDAPN+++AID RL  +   I S+  G+G+AFYYGW MA +
Sbjct: 797  YFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVM 856

Query: 1406 XXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTA 1585
                           Y       D      A +   E+I N +TVQALT Q  +Y+ F +
Sbjct: 857  AIFPFMAVGQALMMKYHGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCS 916

Query: 1586 ASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLI--SNNWSTPYTVFQVIEA 1759
               +PH   I + + + L++  A S   + +A A+ FGL+LI   N    P  V +V+ A
Sbjct: 917  HLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFA 976

Query: 1760 LNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVY 1939
            ++ +  ++  AASYFPEY++A  +AG++F M+ ++  ID    +G  P + G + +  V+
Sbjct: 977  ISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTSSGTYPQLSGEVKLNKVF 1036

Query: 1940 FAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDI 2119
            F YP R    +L G N+    GQT+ALVGPSGCGKST I L+ER YD L G+V +D++D+
Sbjct: 1037 FRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDL 1096

Query: 2120 RDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLE--NITQDQVEKAATLANIHTFVMGL 2293
            R ++ KHLR +IALV QEP LF+ +IRENI YGL+    T +Q+E A + ANIH F+  L
Sbjct: 1097 RQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEYTHEQIETACSKANIHKFIDEL 1156

Query: 2294 PDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKA 2473
            PDGY+T VG  G +LSGGQKQR+AIARA++R+PKILLLDEATSALDTESEK VQ ALD A
Sbjct: 1157 PDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAA 1216

Query: 2474 RLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
               RTC+V+AHRLSTI NA  I+V +NG+ +E+GTH  L+A+RG Y+ L +KQSS
Sbjct: 1217 AKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIAKRGAYFALTQKQSS 1271



 Score =  313 bits (801), Expect = 2e-83
 Identities = 198/593 (33%), Positives = 308/593 (51%), Gaps = 19/593 (3%)
 Frame = +2

Query: 911  SLFDIFKYASPEMRNII-ISLVFTLIRGFTWPAFSIVYG---QLFKIL------------ 1042
            S+F +++Y S   R ++ + ++ +   G   P  SI+ G   Q F  L
Sbjct: 30   SIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSIIMGNVSQNFVTLGTIFLDPNSTAS 89

Query: 1043 --SAGGDDVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQ 1216
              +A   + S + + N L ++ L      +  +  S      E +S R R   F ++M+Q
Sbjct: 90   EKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMVICEKLSNRFRRQFFHSVMRQ 149

Query: 1217 DASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAP 1396
            + +++D  ++  G+L+++L  +   V+     ++      +     G  VAF Y W +
Sbjct: 150  EIAWYD--KNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFIGGFAVAFTYDWLLTL 207

Query: 1397 IGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDA 1576
            I                  L     ++      A  +  E +++ +TV A   QEY
Sbjct: 208  IMMSLSPFMMICGLFLAKLLATAATKEAKQYAVAGGIAEEVLTSIRTVIAFNGQEYECKR 267

Query: 1577 FTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIE 1756
            +  A +   +  I +        A     +  ++ +A+  G   + +      TV  V
Sbjct: 268  YEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYSGRLESGTVLTVFF 327

Query: 1757 ALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRG 1933
            ++ M SM++  A   F     A  +A  ++ +I +   ID     G TP+ I G I++
Sbjct: 328  SVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDAYSTEGQTPSKISGRISVNK 387

Query: 1934 VYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDS 2113
            V F YP R    +L G ++ A  GQTVALVG SGCGKST IQL++R+Y+   G + IDD
Sbjct: 388  VEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDI 447

Query: 2114 DIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGL 2293
             I D ++K+LR  + +V QEP LFN +I +NI YG  +++ + + +A   AN   F+
Sbjct: 448  PIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTF 507

Query: 2294 PDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKA 2473
            P+G +T VG  G ++SGGQKQR+AIARA+VR+PKILLLDEATSALD ESE IVQ AL+ A
Sbjct: 508  PEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSALENA 567

Query: 2474 RLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
              GRT +VIAHRLST++NADKIIV + G+ +E GTH+TL+ ++GLY+ LV  Q
Sbjct: 568  SRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQ 620


>gi|39587899|emb|CAE67917.1| Hypothetical protein CBG13514
            [Caenorhabditis briggsae]
          Length = 1319

 Score =  712 bits (1837), Expect = 0.0
 Identities = 390/893 (43%), Positives = 552/893 (61%), Gaps = 14/893 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            ++ IL+G++  VN G+TVALVG SGCGKST I LL+R+Y+   G I +DG+ +++ N+ +
Sbjct: 430  DVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYYDVLKGNITIDGVDVRDINLEF 489

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR+ + +V QEP +F  T+ ENIR+G   IT +++  ACKMANA +FI  L   Y+T++G
Sbjct: 490  LRTNVAVVSQEPALFNCTIEENIRLGREDITREEMIAACKMANAEKFIKTLPAGYNTLVG 549

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                QLSGGQKQR+AIARA+VR P+ILLLDEATSALD ESE +VQ ALDKA++GRTT+ I
Sbjct: 550  DRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESEGIVQQALDKAAKGRTTIII 609

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
            AHRLSTIRNA  I+    G + E G H  L+++ +G+Y  +V AQ    A
Sbjct: 610  AHRLSTIRNADLIISCKNGQVVEVGDHRTLMAQ-EGLYYDLVTAQTFTDA---VDASAGG 665

Query: 722  XXXXHRSFHRDSVTSDEERELQQSLARDS--TRLRQSMISTTTQVP----------XXXX 865
                  S  R   TS+ E   +Q+   D    R+R S + + T  P
Sbjct: 666  KFSRENSIARQ--TSEHEGIFRQASELDDVLNRVRSSTMGSITNGPVIEEKEQRIGKDAL 723

Query: 866  XXXXXXXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILS 1045
                       A   +LF+I  +A P   ++ I +   ++ GF +P +S+ +     + S
Sbjct: 724  TRLKEELEENNAQRTNLFEILYHAKPHALSVAIGITAAIVGGFIYPTYSVFFTSFINVFS 783

Query: 1046 AGGDDVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDAS 1225
               DD+  +    +L F++LA   GI + +    +G A E+++  LR  +FRN++ Q
Sbjct: 784  GNPDDILSQGHFWALMFLVLAAAQGICSFLMTFFMGIASESLTMDLRNKLFRNVLSQHIG 843

Query: 1226 YFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGX 1405
            +FD  ++  G + +RLATD PN++ AID R + V+T +VS+  G+G+AFYYGW MA +
Sbjct: 844  FFDSPQNASGKICTRLATDVPNLRTAIDFRFSTVITTLVSMIAGIGLAFYYGWQMALLIV 903

Query: 1406 XXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTA 1585
                                  +      ++ ++  E+I N +TVQAL +++  Y  F +
Sbjct: 904  AILPIVGFGQYLRGRRFTGNNVKSASEFADSGKIAIEAIENVRTVQALAREDTFYYKFCS 963

Query: 1586 ASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALN 1765
                PH+ AI     Q LS+  A S +      AY  GL LI +   TP  V +V+ A+
Sbjct: 964  KLDVPHKEAIKEAFIQGLSYGCACSVLYLLNTCAYRMGLALILHRTMTPMRVLRVMYAIT 1023

Query: 1766 MASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFA 1945
            +++ ++  A SYFPEY +A  + GI+F M++QKS ID+  L+G+   + G +  + V FA
Sbjct: 1024 ISTSTLGFATSYFPEYAKATFAGGIIFGMLKQKSEIDSLTLSGEKKKLSGKVIFKNVRFA 1083

Query: 1946 YPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRD 2125
            YP R +  +L G + S + GQT+ALVGPSGCGKST + L+ER+YD L G V ID S+I+
Sbjct: 1084 YPERPQIEILKGLSFSVDPGQTLALVGPSGCGKSTVVALLERFYDTLAGEVFIDGSEIKT 1143

Query: 2126 LSVKHLRDNIALVGQEPTLFNLTIRENITYGLE--NITQDQVEKAATLANIHTFVMGLPD 2299
            L+ ++ R  IA+V QEPTLF+ +I ENI YGL+   +T  +VE+AA LANIH F+  LP+
Sbjct: 1144 LNPENTRSQIAIVSQEPTLFDCSIAENIVYGLDPTTVTMSRVEEAAKLANIHNFISELPE 1203

Query: 2300 GYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARL 2479
            GY+T VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESEKIVQEALD+AR
Sbjct: 1204 GYETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEKIVQEALDRARE 1263

Query: 2480 GRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
            GRTC+VIAHRL+TI NAD I V  NG  IE+GTH  L++++G YY+L +KQ S
Sbjct: 1264 GRTCIVIAHRLNTIMNADCIAVVNNGTIIEQGTHSVLMSQQGAYYKLTQKQMS 1316



 Score =  352 bits (903), Expect = 3e-95
 Identities = 196/492 (39%), Positives = 295/492 (59%), Gaps = 1/492 (0%)
 Frame = +2

Query: 1163 ETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIV 1342
            E M+ RLR +  + I++QD S+FD +    G+L ++L  +   V+     ++      +
Sbjct: 165  EQMNNRLRREFVKAILRQDISWFDTNHS--GTLATKLFDNLERVKEGTGDKIGMAFQYMS 222

Query: 1343 SLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESI 1522
                G  VAF + W +  +                  +     R+     +A ++V E+I
Sbjct: 223  QFITGFIVAFTHSWKLTLVMLAVTPIQALCGFLIAKSMSTFAIRETVRYAKAGKVVEETI 282

Query: 1523 SNWKTVQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGL 1702
            S+ +TV +L    +  + ++ A +   +  +++GL+  +SF    +   ++FA+A+  G+
Sbjct: 283  SSIRTVVSLNGLRHELERYSTAVEEAKKSGVLKGLFLGISFGAMQATNFFSFALAFYIGV 342

Query: 1703 WLISNNWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNR 1882
              + +    P  +     ++ M SM++ LA         A+ +A  ++ ++ +K VID+
Sbjct: 343  GWVHDGSLAPGDMLTTFSSVMMGSMALGLAGPQLAVLGTAQGAASSIYEVLDRKPVIDSS 402

Query: 1883 GLTGDTPT-IKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQ 2059
               G     IKG+I +  V+F YP+R+   +L G N+  N GQTVALVG SGCGKST I
Sbjct: 403  SSAGRKDMKIKGDITVENVHFTYPSRQDVPILRGMNLRVNAGQTVALVGSSGCGKSTIIS 462

Query: 2060 LIERYYDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQD 2239
            L+ RYYD L G++ ID  D+RD++++ LR N+A+V QEP LFN TI ENI  G E+IT++
Sbjct: 463  LLLRYYDVLKGNITIDGVDVRDINLEFLRTNVAVVSQEPALFNCTIEENIRLGREDITRE 522

Query: 2240 QVEKAATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEAT 2419
            ++  A  +AN   F+  LP GY+T VG  G +LSGGQKQR+AIARA+VR+PKILLLDEAT
Sbjct: 523  EMIAACKMANAEKFIKTLPAGYNTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEAT 582

Query: 2420 SALDTESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLAR 2599
            SALD ESE IVQ+ALDKA  GRT ++IAHRLSTI+NAD II C+NG+ +E G H+TL+A+
Sbjct: 583  SALDAESEGIVQQALDKAAKGRTTIIIAHRLSTIRNADLIISCKNGQVVEVGDHRTLMAQ 642

Query: 2600 RGLYYRLVEKQS 2635
             GLYY LV  Q+
Sbjct: 643  EGLYYDLVTAQT 654


>gi|39585393|emb|CAE61715.1| Hypothetical protein CBG05664
            [Caenorhabditis briggsae]
          Length = 1294

 Score =  710 bits (1832), Expect = 0.0
 Identities = 395/894 (44%), Positives = 548/894 (61%), Gaps = 16/894 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            +++ILK VS E  PG+T+ALVG SGCGKST I LL RFYN  AG I +D I I+++NI++
Sbjct: 397  DVQILKDVSLEAQPGQTIALVGSSGCGKSTIIQLLQRFYNPDAGKIYIDDIAIEDFNIKY 456

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  +G+V QEP +F  ++ +NIR G   +    I  A K ANA +FI    +  +T++G
Sbjct: 457  LRQLVGVVSQEPNLFNTSIEQNIRYGRADVDSDAINRALKEANALDFIKTFPEGLNTLVG 516

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
               VQ+SGGQKQR+AIARA+VR P+ILLLDEATSALD ESE +VQ ALD AS GRTT+ I
Sbjct: 517  DRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESVVQAALDNASRGRTTIVI 576

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
            AHRLST+RNA KI+V   G + E GTHD LI +  G+Y  +V AQ
Sbjct: 577  AHRLSTVRNADKIIVMKAGKVMEIGTHDTLIEQK-GLYHELVHAQVFADVDEKPRAKKEA 635

Query: 722  XXXXHR--SFHRDSVTSDEERELQQSLA---------RDSTRLRQSMISTTTQVPXXXXX 868
                 R  S  + S+   +E + ++            ++  RLR+ +
Sbjct: 636  ERRLSRQTSARKGSLIKTQESQAEEKSGPPPAPEPAEKEIKRLRKEL------------- 682

Query: 869  XXXXXXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILS- 1045
                     GA++A+LF I KYA PE   I  +++  LI+G   PAFS+ + Q+  + S
Sbjct: 683  ------EEEGAVKANLFKILKYARPEWMYIFFAIIAALIQGAVMPAFSLFFSQIINVFSN 736

Query: 1046 AGGDDVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDAS 1225
               + +       +L F++LA   G S L   +  G A E ++ R+R  V+RN+++QDA+
Sbjct: 737  PDREQMKKDGHFWALMFLVLAAIQGTSMLFQCAFFGVAAEGLTMRVRSKVYRNVLRQDAT 796

Query: 1226 YFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGX 1405
            YFD  +H+ G +T+RLATDAPN+++AID RL  V   I S+  G+G+AFYYGW MA +
Sbjct: 797  YFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSVFNAIASVGGGLGIAFYYGWQMALLVM 856

Query: 1406 XXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTA 1585
                           Y       D      + +   E+I N +TVQALT Q  +Y+ F +
Sbjct: 857  AIFPFMAVGQALVIKYHGGSATADAKEMENSGKTAMEAIENIRTVQALTLQTKLYNIFCS 916

Query: 1586 ASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNN--WSTPYTVFQVIEA 1759
               SPH   + + + + L++  A S   + +A A+ FGL+LI N     +P  V +V+ A
Sbjct: 917  HLDSPHSGNVSKAIIRGLTYGFANSIQFFTYAAAFRFGLFLIFNQNVLMSPEHVLKVLFA 976

Query: 1760 LNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVY 1939
            ++ +  ++  AASYFPEY++A  +AG++F M+ ++  ID     G  P + G + +  V+
Sbjct: 977  ISFSFGTIGFAASYFPEYIKATFAAGLIFNMLEEEPRIDGMTNAGTLPALSGEVKLNKVF 1036

Query: 1940 FAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDI 2119
            F YP R    +L G ++    GQT+ALVGPSGCGKST I L+ER YD L G+V ID++++
Sbjct: 1037 FRYPERPAVPILQGLDVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTIDNNNL 1096

Query: 2120 RDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLE--NITQDQVEKAATLANIHTFVMGL 2293
            R ++ KHLR +IALV QEP LF+ +IRENI YGL+    T++ +  A   ANIH F+  L
Sbjct: 1097 RQMNPKHLRKHIALVSQEPILFDTSIRENIIYGLQPGEYTEEAIAVACEKANIHKFISEL 1156

Query: 2294 PDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKA 2473
            PDGY T VG  G +LSGGQKQR+AIARA++R+PKILLLDEATSALDTESEK VQ ALD A
Sbjct: 1157 PDGYQTRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQIALDAA 1216

Query: 2474 RLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
               RTC+V+AHRLSTI NA  I+V +NGK +E+GTH  L+A+RG Y+ L +KQS
Sbjct: 1217 AKDRTCIVVAHRLSTIVNAGCIMVVKNGKVVEQGTHLELMAKRGAYFALTQKQS 1270



 Score =  318 bits (815), Expect = 4e-85
 Identities = 198/592 (33%), Positives = 303/592 (50%), Gaps = 18/592 (3%)
 Frame = +2

Query: 911  SLFDIFKYASPEMR-NIIISLVFTLIRGFTWPAFSIVYGQLFK----------------I 1039
            S+F +F+Y S   R  +I+ ++ +   G   P  SI+ G + +                +
Sbjct: 31   SIFQLFRYTSTMDRIMLIVGILVSCATGLGLPLMSIIMGNVSQNFVEIGTILMNSTDPAV 90

Query: 1040 LSAGGDDVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQD 1219
            +    DD S   + N L ++ L      + +I  S      E +S R R + F ++M+ +
Sbjct: 91   IKKAKDDFSHDVIQNCLQYVYLGAGIFAAGMIQASCFLIICENLSNRFRREFFYSVMRHE 150

Query: 1220 ASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPI 1399
             +++D  ++  G+L+++L  +   V+     ++      +     G  VAF Y W +  I
Sbjct: 151  IAWYD--KNTSGTLSNKLFDNLERVREGTGDKVGLAFQMMAQFLGGFAVAFSYDWLLTLI 208

Query: 1400 GXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAF 1579
                              L     ++      A  +  E +++ +TV A   QEY    +
Sbjct: 209  MMSLSPFMMICGLFLAKLLATAATKEAKQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRY 268

Query: 1580 TAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEA 1759
              A     +  I +        A     +  ++ +A+  G   + N      TV  V  +
Sbjct: 269  EEALSHGRKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGTNFVYNGRLDSGTVLTVFFS 328

Query: 1760 LNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGV 1936
            + M SM++  A   F     A  +A  ++ +I +   ID     G TP  I G I ++ +
Sbjct: 329  VMMGSMALGQAGQQFATIGTALGAAASLYEVIDRTPEIDAYSTKGVTPEKISGRIKIQNI 388

Query: 1937 YFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSD 2116
             F YP R    +L   ++ A  GQT+ALVG SGCGKST IQL++R+Y+   G + IDD
Sbjct: 389  EFTYPTRPDVQILKDVSLEAQPGQTIALVGSSGCGKSTIIQLLQRFYNPDAGKIYIDDIA 448

Query: 2117 IRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLP 2296
            I D ++K+LR  + +V QEP LFN +I +NI YG  ++  D + +A   AN   F+   P
Sbjct: 449  IEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRADVDSDAINRALKEANALDFIKTFP 508

Query: 2297 DGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKAR 2476
            +G +T VG  G ++SGGQKQR+AIARA+VR+PKILLLDEATSALD ESE +VQ ALD A
Sbjct: 509  EGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESVVQAALDNAS 568

Query: 2477 LGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
             GRT +VIAHRLST++NADKIIV + GK +E GTH TL+ ++GLY+ LV  Q
Sbjct: 569  RGRTTIVIAHRLSTVRNADKIIVMKAGKVMEIGTHDTLIEQKGLYHELVHAQ 620



 Score =  215 bits (547), Expect = 5e-54
 Identities = 117/229 (51%), Positives = 156/229 (68%), Gaps = 2/229 (0%)
 Frame = +2

Query: 11   ILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWLRS 190
            IL+G+   V PG+T+ALVG SGCGKST I LL R Y+   G + +D   +++ N + LR
Sbjct: 1047 ILQGLDVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTIDNNNLRQMNPKHLRK 1106

Query: 191  TIGIVQQEPIIFVATVAENIRMG--DVLITDQDIEEACKMANAHEFICKLSDRYDTVIGA 364
             I +V QEPI+F  ++ ENI  G      T++ I  AC+ AN H+FI +L D Y T +G
Sbjct: 1107 HIALVSQEPILFDTSIRENIIYGLQPGEYTEEAIAVACEKANIHKFISELPDGYQTRVGE 1166

Query: 365  GAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIA 544
               QLSGGQKQR+AIARA++R P+ILLLDEATSALDTESE+ VQ ALD A++ RT + +A
Sbjct: 1167 KGTQLSGGQKQRIAIARALIRNPKILLLDEATSALDTESEKQVQIALDAAAKDRTCIVVA 1226

Query: 545  HRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERA 691
            HRLSTI NA  I+V   G + E+GTH EL++K  G Y ++ + Q I +A
Sbjct: 1227 HRLSTIVNAGCIMVVKNGKVVEQGTHLELMAK-RGAYFALTQKQSINQA 1274


>gi|283551|pir||S27337 multidrug resistance protein A - Caenorhabditis
            elegans
 gi|6809|emb|CAA46190.1| P-glycoprotein A [Caenorhabditis elegans]
          Length = 1321

 Score =  692 bits (1787), Expect = 0.0
 Identities = 384/897 (42%), Positives = 547/897 (60%), Gaps = 20/897 (2%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            ++ IL+G++  VN G+TVALVG SGCGKST I LL+R+Y+   G I +DG+ +++ N+ +
Sbjct: 430  DVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYYDVLKGKITIDGVDVRDINLEF 489

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  + +V QEP +F  T+ ENI +G   IT +++  ACKMANA +FI  L + Y+T++G
Sbjct: 490  LRKNVAVVSQEPALFNCTIEENISLGKEGITREEMVAACKMANAEKFIKTLPNGYNTLVG 549

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                QLSGGQKQR+AIARA+VR P+ILLLDEATSALD ESE +VQ ALDKA++GRTT+ I
Sbjct: 550  DRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESEGIVQQALDKAAKGRTTIII 609

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
            AHRLSTIRNA  I+    G + E G H  L+++  G+Y  +V AQ    A
Sbjct: 610  AHRLSTIRNADLIISCKNGQVVEVGDHRALMAQ-QGLYYDLVTAQTFTDA---------V 659

Query: 722  XXXXHRSFHRDS----VTSDEERELQQSLARDS--TRLRQSMISTTTQVP---------- 853
                   F R++     TS+ E   +Q+   D    R+R S I + T  P
Sbjct: 660  DSAAEGKFSRENSVARQTSEHEGLSRQASEMDDIMNRVRSSTIGSITNGPVIDEKEERIG 719

Query: 854  XXXXXXXXXXXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLF 1033
                           A + +LF+I  +A P   ++ I +    I GF +P +S+ +
Sbjct: 720  KDALSRLKQELEENNAQKTNLFEILYHARPHALSLFIGMSTATIGGFIYPTYSVFFTSFM 779

Query: 1034 KILSAGGDDVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQ 1213
             + +    D   +    +L F++LA   GI + +    +G A E+++  LR  +FRN++
Sbjct: 780  NVFAGNPADFLSQGHFWALMFLVLAAAQGICSFLMTFFMGIASESLTRDLRNKLFRNVLS 839

Query: 1214 QDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMA 1393
            Q   +FD  ++  G +++RLATD PN++ AID R + V+T +VS+  G+G+AF+YGW MA
Sbjct: 840  QHIGFFDSPQNASGKISTRLATDVPNLRTAIDFRFSTVITTLVSMVAGIGLAFFYGWQMA 899

Query: 1394 PIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYD 1573
             +                     +  +      ++ ++  E+I N +TVQAL +++  Y+
Sbjct: 900  LLIIAILPIVAFGQYLRGRRFTGKNVKSASEFADSGKIAIEAIENVRTVQALAREDTFYE 959

Query: 1574 AFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWST--PYTVFQ 1747
             F      PH+ AI     Q LS+  A S +      AY  GL LI  +  T  P  V +
Sbjct: 960  NFCEKLDIPHKEAIKEAFIQGLSYGCASSVLYLLNTCAYRMGLALIITDPPTMQPMRVLR 1019

Query: 1748 VIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINM 1927
            V+ A+ +++ ++  A SYFPEY +A  + GI+F M+R+ S ID+  L G+   + G +
Sbjct: 1020 VMYAITISTSTLGFATSYFPEYAKATFAGGIIFGMLRKISKIDSLSLAGEKKKLYGKVIF 1079

Query: 1928 RGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKID 2107
            + V FAYP R    +L G + S   GQT+ALVGPSGCGKST + L+ER+YD L G + ID
Sbjct: 1080 KNVRFAYPERPEIEILKGLSFSVEPGQTLALVGPSGCGKSTVVALLERFYDTLGGEIFID 1139

Query: 2108 DSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLE--NITQDQVEKAATLANIHTF 2281
             S+I+ L+ +H R  IA+V QEPTLF+ +I ENI YGL+  ++T  QVE+AA LANIH F
Sbjct: 1140 GSEIKTLNPEHTRSQIAIVSQEPTLFDCSIAENIIYGLDPSSVTMAQVEEAARLANIHNF 1199

Query: 2282 VMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEA 2461
            +  LP+G++T VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESEK+VQEA
Sbjct: 1200 IAELPEGFETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEKVVQEA 1259

Query: 2462 LDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
            LD+AR GRTC+VIAHRL+T+ NAD I V  NG  IE+GTH  L++ +G YY+L +KQ
Sbjct: 1260 LDRAREGRTCIVIAHRLNTVMNADCIAVVSNGTIIEKGTHTQLMSEKGAYYKLTQKQ 1316



 Score =  346 bits (888), Expect = 1e-93
 Identities = 194/492 (39%), Positives = 293/492 (59%), Gaps = 1/492 (0%)
 Frame = +2

Query: 1163 ETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIV 1342
            E M+ RLR +  ++I++Q+ S+FD +    G+L ++L  +   V+     ++      +
Sbjct: 165  EQMNNRLRREFVKSILRQEISWFDTNHS--GTLATKLFDNLERVKEGTGDKIGMAFQYLS 222

Query: 1343 SLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESI 1522
                G  VAF + W +  +                  +     R+     +A ++V E+I
Sbjct: 223  QFITGFIVAFTHSWQLTLVMLAVTPIQALCGFAIAKSMSTFAIRETLRYAKAGKVVEETI 282

Query: 1523 SNWKTVQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGL 1702
            S+ +TV +L    Y  + ++ A +   +  +++GL+  +SF    +    +FA+A+  G+
Sbjct: 283  SSIRTVVSLNGLRYELERYSTAVEEAKKAGVLKGLFLGISFGAMQASNFISFALAFYIGV 342

Query: 1703 WLISNNWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNR 1882
              + +       +     ++ M SM++ LA         A+ +A  ++ ++ +K VID+
Sbjct: 343  GWVHDGSLNFGDMLTTFSSVMMGSMALGLAGPQLAVLGTAQGAASGIYEVLDRKPVIDSS 402

Query: 1883 GLTGDTPT-IKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQ 2059
               G     IKG+I +  V+F YP+R    +L G N+  N GQTVALVG SGCGKST I
Sbjct: 403  SKAGRKDMKIKGDITVENVHFTYPSRPDVPILRGMNLRVNAGQTVALVGSSGCGKSTIIS 462

Query: 2060 LIERYYDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQD 2239
            L+ RYYD L G + ID  D+RD++++ LR N+A+V QEP LFN TI ENI+ G E IT++
Sbjct: 463  LLLRYYDVLKGKITIDGVDVRDINLEFLRKNVAVVSQEPALFNCTIEENISLGKEGITRE 522

Query: 2240 QVEKAATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEAT 2419
            ++  A  +AN   F+  LP+GY+T VG  G +LSGGQKQR+AIARA+VR+PKILLLDEAT
Sbjct: 523  EMVAACKMANAEKFIKTLPNGYNTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEAT 582

Query: 2420 SALDTESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLAR 2599
            SALD ESE IVQ+ALDKA  GRT ++IAHRLSTI+NAD II C+NG+ +E G H+ L+A+
Sbjct: 583  SALDAESEGIVQQALDKAAKGRTTIIIAHRLSTIRNADLIISCKNGQVVEVGDHRALMAQ 642

Query: 2600 RGLYYRLVEKQS 2635
            +GLYY LV  Q+
Sbjct: 643  QGLYYDLVTAQT 654


>gi|17541710|ref|NP_502413.1| P-GlycoProtein related (pgp-1)
            [Caenorhabditis elegans]
 gi|29429182|sp|P34712|MDR1_CAEEL Multidrug resistance protein 1
            (P-glycoprotein A)
 gi|7505559|pir||T23476 hypothetical protein K08E7.9 - Caenorhabditis
            elegans
 gi|3878418|emb|CAB01232.1| Hypothetical protein K08E7.9
            [Caenorhabditis elegans]
          Length = 1321

 Score =  692 bits (1787), Expect = 0.0
 Identities = 384/897 (42%), Positives = 547/897 (60%), Gaps = 20/897 (2%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            ++ IL+G++  VN G+TVALVG SGCGKST I LL+R+Y+   G I +DG+ +++ N+ +
Sbjct: 430  DVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYYDVLKGKITIDGVDVRDINLEF 489

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  + +V QEP +F  T+ ENI +G   IT +++  ACKMANA +FI  L + Y+T++G
Sbjct: 490  LRKNVAVVSQEPALFNCTIEENISLGKEGITREEMVAACKMANAEKFIKTLPNGYNTLVG 549

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                QLSGGQKQR+AIARA+VR P+ILLLDEATSALD ESE +VQ ALDKA++GRTT+ I
Sbjct: 550  DRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESEGIVQQALDKAAKGRTTIII 609

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
            AHRLSTIRNA  I+    G + E G H  L+++  G+Y  +V AQ    A
Sbjct: 610  AHRLSTIRNADLIISCKNGQVVEVGDHRALMAQ-QGLYYDLVTAQTFTDA---------V 659

Query: 722  XXXXHRSFHRDS----VTSDEERELQQSLARDS--TRLRQSMISTTTQVP---------- 853
                   F R++     TS+ E   +Q+   D    R+R S I + T  P
Sbjct: 660  DSAAEGKFSRENSVARQTSEHEGLSRQASEMDDIMNRVRSSTIGSITNGPVIDEKEERIG 719

Query: 854  XXXXXXXXXXXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLF 1033
                           A + +LF+I  +A P   ++ I +    I GF +P +S+ +
Sbjct: 720  KDALSRLKQELEENNAQKTNLFEILYHARPHALSLFIGMSTATIGGFIYPTYSVFFTSFM 779

Query: 1034 KILSAGGDDVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQ 1213
             + +    D   +    +L F++LA   GI + +    +G A E+++  LR  +FRN++
Sbjct: 780  NVFAGNPADFLSQGHFWALMFLVLAAAQGICSFLMTFFMGIASESLTRDLRNKLFRNVLS 839

Query: 1214 QDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMA 1393
            Q   +FD  ++  G +++RLATD PN++ AID R + V+T +VS+  G+G+AF+YGW MA
Sbjct: 840  QHIGFFDSPQNASGKISTRLATDVPNLRTAIDFRFSTVITTLVSMVAGIGLAFFYGWQMA 899

Query: 1394 PIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYD 1573
             +                     +  +      ++ ++  E+I N +TVQAL +++  Y+
Sbjct: 900  LLIIAILPIVAFGQYLRGRRFTGKNVKSASEFADSGKIAIEAIENVRTVQALAREDTFYE 959

Query: 1574 AFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWST--PYTVFQ 1747
             F      PH+ AI     Q LS+  A S +      AY  GL LI  +  T  P  V +
Sbjct: 960  NFCEKLDIPHKEAIKEAFIQGLSYGCASSVLYLLNTCAYRMGLALIITDPPTMQPMRVLR 1019

Query: 1748 VIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINM 1927
            V+ A+ +++ ++  A SYFPEY +A  + GI+F M+R+ S ID+  L G+   + G +
Sbjct: 1020 VMYAITISTSTLGFATSYFPEYAKATFAGGIIFGMLRKISKIDSLSLAGEKKKLYGKVIF 1079

Query: 1928 RGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKID 2107
            + V FAYP R    +L G + S   GQT+ALVGPSGCGKST + L+ER+YD L G + ID
Sbjct: 1080 KNVRFAYPERPEIEILKGLSFSVEPGQTLALVGPSGCGKSTVVALLERFYDTLGGEIFID 1139

Query: 2108 DSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLE--NITQDQVEKAATLANIHTF 2281
             S+I+ L+ +H R  IA+V QEPTLF+ +I ENI YGL+  ++T  QVE+AA LANIH F
Sbjct: 1140 GSEIKTLNPEHTRSQIAIVSQEPTLFDCSIAENIIYGLDPSSVTMAQVEEAARLANIHNF 1199

Query: 2282 VMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEA 2461
            +  LP+G++T VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESEK+VQEA
Sbjct: 1200 IAELPEGFETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEKVVQEA 1259

Query: 2462 LDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
            LD+AR GRTC+VIAHRL+T+ NAD I V  NG  IE+GTH  L++ +G YY+L +KQ
Sbjct: 1260 LDRAREGRTCIVIAHRLNTVMNADCIAVVSNGTIIEKGTHTQLMSEKGAYYKLTQKQ 1316



 Score =  346 bits (888), Expect = 1e-93
 Identities = 194/492 (39%), Positives = 293/492 (59%), Gaps = 1/492 (0%)
 Frame = +2

Query: 1163 ETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIV 1342
            E M+ RLR +  ++I++Q+ S+FD +    G+L ++L  +   V+     ++      +
Sbjct: 165  EQMNNRLRREFVKSILRQEISWFDTNHS--GTLATKLFDNLERVKEGTGDKIGMAFQYLS 222

Query: 1343 SLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESI 1522
                G  VAF + W +  +                  +     R+     +A ++V E+I
Sbjct: 223  QFITGFIVAFTHSWQLTLVMLAVTPIQALCGFAIAKSMSTFAIRETLRYAKAGKVVEETI 282

Query: 1523 SNWKTVQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGL 1702
            S+ +TV +L    Y  + ++ A +   +  +++GL+  +SF    +    +FA+A+  G+
Sbjct: 283  SSIRTVVSLNGLRYELERYSTAVEEAKKAGVLKGLFLGISFGAMQASNFISFALAFYIGV 342

Query: 1703 WLISNNWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNR 1882
              + +       +     ++ M SM++ LA         A+ +A  ++ ++ +K VID+
Sbjct: 343  GWVHDGSLNFGDMLTTFSSVMMGSMALGLAGPQLAVLGTAQGAASGIYEVLDRKPVIDSS 402

Query: 1883 GLTGDTPT-IKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQ 2059
               G     IKG+I +  V+F YP+R    +L G N+  N GQTVALVG SGCGKST I
Sbjct: 403  SKAGRKDMKIKGDITVENVHFTYPSRPDVPILRGMNLRVNAGQTVALVGSSGCGKSTIIS 462

Query: 2060 LIERYYDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQD 2239
            L+ RYYD L G + ID  D+RD++++ LR N+A+V QEP LFN TI ENI+ G E IT++
Sbjct: 463  LLLRYYDVLKGKITIDGVDVRDINLEFLRKNVAVVSQEPALFNCTIEENISLGKEGITRE 522

Query: 2240 QVEKAATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEAT 2419
            ++  A  +AN   F+  LP+GY+T VG  G +LSGGQKQR+AIARA+VR+PKILLLDEAT
Sbjct: 523  EMVAACKMANAEKFIKTLPNGYNTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEAT 582

Query: 2420 SALDTESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLAR 2599
            SALD ESE IVQ+ALDKA  GRT ++IAHRLSTI+NAD II C+NG+ +E G H+ L+A+
Sbjct: 583  SALDAESEGIVQQALDKAAKGRTTIIIAHRLSTIRNADLIISCKNGQVVEVGDHRALMAQ 642

Query: 2600 RGLYYRLVEKQS 2635
            +GLYY LV  Q+
Sbjct: 643  QGLYYDLVTAQT 654


>gi|17567269|ref|NP_510128.1| P-GlycoProtein related (146.8 kD)
            (pgp-14) [Caenorhabditis elegans]
 gi|7499665|pir||T21268 hypothetical protein F22E10.3 - Caenorhabditis
            elegans
 gi|3876293|emb|CAA91801.1| Hypothetical protein F22E10.3
            [Caenorhabditis elegans]
 gi|40764042|gb|AAR89639.1| P-glycoprotein related (146.8 kD) (pgp-14)
            [Caenorhabditis elegans]
          Length = 1327

 Score =  692 bits (1786), Expect = 0.0
 Identities = 385/893 (43%), Positives = 548/893 (61%), Gaps = 16/893 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            + KIL G++  V PG +VALVGHSGCGKSTS+GLL R Y   AG + +DG  ++E NI W
Sbjct: 443  DAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIEW 502

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR+T+GIVQQEPI+F  T+  N+ +G+   T + + E CKMANAH+FI K+   YDT+IG
Sbjct: 503  LRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDTLIG 562

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
             G VQLSGGQKQRVAIAR ++R P++LLLDEATSALD +SE +VQ+AL+ AS+GRTT+ I
Sbjct: 563  DGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTTIMI 622

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIE---RAXXXXXXX 712
            AHRLSTIR A KI+ F++G+I E G H+EL+ +  G Y  +VKAQ+ +    A
Sbjct: 623  AHRLSTIREADKIVFFEKGVIVEAGNHEELV-RLGGRYFDLVKAQQFKADPEATEEFEEE 681

Query: 713  XXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXXX 892
                    RS  R S+TS   R   ++  R ++ L  S   +
Sbjct: 682  EIDLDDTSRSSRRSSMTS--ARSGSEAFRRGNS-LNDSFSGSKRSAQADAENSAFAANEA 738

Query: 893  X-----GAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFK---ILSA 1048
                  G + A   DIFK A      + +  VF LIRG   PA ++++G +F+    +
Sbjct: 739  AIMAEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPY 798

Query: 1049 GGDDVSIKALLNSLWFILLAFTG-----GISTLISGSLLGKAGETMSGRLRMDVFRNIMQ 1213
            GG       +++ +   ++AF         S L S  L     E +S R R+  FRN++
Sbjct: 799  GG------RMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLY 852

Query: 1214 QDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMA 1393
            QDASYFD+  H  G L +RLA+DAPN++A +D R+ +V+  + ++   + +AF Y W +
Sbjct: 853  QDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVIYALAAIIANIAIAFIYCWQIG 912

Query: 1394 PIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYD 1573
             +G                 +       + +  +A R+  E I N KT+Q LT+ E  +D
Sbjct: 913  ILGTSLILLLAFVMIGLAYKISLMNVEQIQND-DAGRIAIEIIENVKTIQLLTRCELFFD 971

Query: 1574 AFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVI 1753
             +  +SK   R  + +G+ ++++++L  SF+ +     Y  G+ +I     +    F+ I
Sbjct: 972  HYQTSSKQQKRSELKKGMIEAINYSLTQSFMYFMMCFTYAVGIRIIYQGDKSSDDTFKGI 1031

Query: 1754 EALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRG 1933
             A+ + +++VM +A YFPE+V+A+ +AG++F +I +K    +  + GD P I+GNI
Sbjct: 1032 IAMMLGAVAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDL-MEGDRPEIRGNILFEN 1090

Query: 1934 VYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDS 2113
            V F+YP R  Q ++ G   +A  GQTVALVGPSG GKST I ++ER+YD   G+++ID
Sbjct: 1091 VKFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQ 1150

Query: 2114 DIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGL 2293
            DIR LS+ HLR  +ALVGQEP LF  TIREN+  GL+++  +++ +A  LAN + F+  L
Sbjct: 1151 DIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQALELANANRFLANL 1210

Query: 2294 PDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKA 2473
            P G DT VG  GG+LSGGQKQR+AIARA+VRDPKILLLDEATSALD+ESE+ VQEALD+A
Sbjct: 1211 PAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRA 1270

Query: 2474 RLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
            R GRTC+ IAHRLS+IQN+D I+    GK  E G H  L+ ++G YY+L++KQ
Sbjct: 1271 REGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQKGRYYKLIKKQ 1323



 Score =  304 bits (779), Expect = 6e-81
 Identities = 187/587 (31%), Positives = 305/587 (51%), Gaps = 9/587 (1%)
 Frame = +2

Query: 899  AMEASLFDIFKYASP-EMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSA---GGDDVS 1066
            A   S+  +F+Y    +   + I  +  +I G + P  ++V G++   L
Sbjct: 85   AQPVSIPGLFRYGKKFDYLLLFIGTICAIISGVSQPILALVSGRVTNALLVYPPTSKQFR 144

Query: 1067 IKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRH 1246
             KA  N   F+ +     I+  I           +  ++R     ++++Q+A +FD  ++
Sbjct: 145  NKANENVYIFLGIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFD--KN 202

Query: 1247 NVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXX 1426
            + G++T++L      ++  I  +L  +L G   L   + VA+ Y W +A +
Sbjct: 203  HSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPTCC 262

Query: 1427 XXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHR 1606
                     +     +++    +A  +  ES+   +TVQA   QE M   + A  +   +
Sbjct: 263  ICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRK 322

Query: 1607 RAIVRGLWQSLSFALAGSFVMWNFAI---AYMFGLWLISNNW-STPYTVFQVIEALNMAS 1774
             A+ +G W        G F  W F+      ++G +L+     +TP  VF V+ ++ + +
Sbjct: 323  FAVWKGFWSGF---FGGLFFFWLFSFLGCGMLYGAYLLKVGIITTPGDVFIVVMSMLLGA 379

Query: 1775 MSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDT-PTIKGNINMRGVYFAYP 1951
              + L + +    + AR+SA  ++  I +   ID     G     + G +    V+F YP
Sbjct: 380  YFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVGRVKFENVHFRYP 439

Query: 1952 NRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLS 2131
            +R+   +L+G N+    G +VALVG SGCGKST++ L+ R Y+   G+V ID +D+R+L+
Sbjct: 440  SRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELN 499

Query: 2132 VKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDT 2311
            ++ LR+ + +V QEP LFN TI  N+  G    T++ + +   +AN H F+  +P GYDT
Sbjct: 500  IEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYDT 559

Query: 2312 SVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTC 2491
             +G  G +LSGGQKQRVAIAR ++RDPK+LLLDEATSALD +SE IVQ AL+ A  GRT
Sbjct: 560  LIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESIVQSALNNASKGRTT 619

Query: 2492 VVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
            ++IAHRLSTI+ ADKI+    G  +E G H+ L+   G Y+ LV+ Q
Sbjct: 620  IMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQ 666


>gi|39587988|emb|CAE57219.1| Hypothetical protein CBG00079
            [Caenorhabditis briggsae]
          Length = 1327

 Score =  689 bits (1777), Expect = 0.0
 Identities = 386/892 (43%), Positives = 548/892 (61%), Gaps = 15/892 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            E KIL G++  V PG +VALVGHSGCGKSTS+GLL R Y   AG + +DG  ++E NI W
Sbjct: 443  EAKILNGLNLTVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELNIDW 502

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR+ +GIVQQEPI+F  T+  N+ +G+   T + + E CKMANAH+FI K+   YDT+IG
Sbjct: 503  LRNVVGIVQQEPILFNDTIHNNLLIGNPGATREKMIEVCKMANAHDFIEKMPKGYDTLIG 562

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
             G VQLSGGQKQRVAIAR ++R P+ILLLDEATSALD +SE +VQ+AL+ A++GRTT+ I
Sbjct: 563  DGGVQLSGGQKQRVAIARTLIRDPKILLLDEATSALDAQSESVVQSALNNAAKGRTTIMI 622

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIE---RAXXXXXXX 712
            AHRLSTIR A KI+ F++G+I E G H+EL+    G Y  +VKAQ+ +    A
Sbjct: 623  AHRLSTIREADKIVFFEKGVIVEAGNHEELVHLG-GRYFDLVKAQQFKADPEATEEFEEE 681

Query: 713  XXXXXXXHRSFHRDSVTS----DEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXX 880
                    RS  R S+TS     E  +   SL    +  R+S  +
Sbjct: 682  EIDLDDNSRSSRRSSMTSARSGSEAFQRGNSLNDSFSGSRRSARADAEN--DAFAAHEAE 739

Query: 881  XXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFK---ILSAG 1051
                 G + A   DIFK A      + +  VF LIRG   PA ++++G +F+    +  G
Sbjct: 740  VMAQDGQITAGYLDIFKNAKGNYIYMFLGTVFALIRGLELPALALIFGWVFEGFTFVPYG 799

Query: 1052 GDDVSIKALLNSLWFILLAFTG-----GISTLISGSLLGKAGETMSGRLRMDVFRNIMQQ 1216
            G       +++ +   ++AF        IS + S  L     E +S R R+  FRN++ Q
Sbjct: 800  G------RMMHRMAMAVIAFASVGVGVWISQVASSVLFAIVSENLSLRFRVQSFRNLLYQ 853

Query: 1217 DASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAP 1396
            DASYFD+  H  G L +RLA+DAPN++A +D R+ +V+  + ++   + +AF Y W +A
Sbjct: 854  DASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVIYALAAIIANIVIAFIYCWQVAI 913

Query: 1397 IGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDA 1576
            +G                 +       + +  EA R   E I N KT+Q LT+ E  +D
Sbjct: 914  LGTSLILLLAFVMIGLAYKISLMNIEQIKND-EAGRTAIEIIENVKTIQLLTRCELFFDH 972

Query: 1577 FTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIE 1756
            +  +SK   R  + +G+ +++++++  SF+ +     Y  G+ +I +   +    F+ I
Sbjct: 973  YQTSSKQQKRSELKKGMIEAINYSITQSFMYFMMCFTYAVGIRVIYDGDKSSDVTFKGII 1032

Query: 1757 ALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGV 1936
            ++ + +++VM +A YFPE+V+A+ +AG++F +I +K    +  + GD P I+GNI    V
Sbjct: 1033 SMMLGAVAVMNSAQYFPEFVKAKTAAGLLFNIIYRKPRTGDL-MEGDRPEIRGNILFENV 1091

Query: 1937 YFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSD 2116
             F+YP R  Q ++ G   +A  GQTVALVGPSG GKST I ++ER+YD   G ++ID  D
Sbjct: 1092 KFSYPQRPLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGVLRIDGQD 1151

Query: 2117 IRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLP 2296
            IR+LS+ HLR  +ALVGQEP LF  +IREN+  GL+++  +++ KA  LAN + F+  LP
Sbjct: 1152 IRNLSLYHLRTQMALVGQEPRLFAGSIRENVCLGLKDVPLEKINKALELANANRFLANLP 1211

Query: 2297 DGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKAR 2476
             G DT VG  GG+LSGGQKQR+AIARA+VRDPKILLLDEATSALD+ESE+ VQEALD+AR
Sbjct: 1212 AGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAR 1271

Query: 2477 LGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
             GRTC+ IAHRLS+IQN+D I+    GK  E G H  L+ ++G YY+L++KQ
Sbjct: 1272 EGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHAQLMQKKGRYYKLIKKQ 1323



 Score =  301 bits (770), Expect = 7e-80
 Identities = 186/587 (31%), Positives = 305/587 (51%), Gaps = 9/587 (1%)
 Frame = +2

Query: 899  AMEASLFDIFKYASP-EMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSA---GGDDVS 1066
            A   S+  +F+Y    +   + I  +  +I G + P  ++V G++   L
Sbjct: 85   AQPVSIPGLFRYGKRFDYLLLFIGTICAIISGVSQPIMALVSGRVTNALLVYPPTSKQFR 144

Query: 1067 IKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRH 1246
             KA  N   F+ +     I+  I           +  ++R     ++++Q+A +FD  ++
Sbjct: 145  NKANENVYIFLGIGIFISITNWIQYMCFQHCCSRVMAQMRHRFVYSVLRQNAGWFD--KN 202

Query: 1247 NVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXX 1426
            + G++T++L      ++  I  +L  +L G   L   + VA+ Y W +A +
Sbjct: 203  HSGTITTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLASMMLGVAPVCC 262

Query: 1427 XXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHR 1606
                     +     +++    +A  +  ES+   +TVQA   QE M   +    +   R
Sbjct: 263  ICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYQTELEKGRR 322

Query: 1607 RAIVRGLWQSLSFALAGSFVMWNFAI---AYMFGLWLISNNW-STPYTVFQVIEALNMAS 1774
             A+ +G W        G F +  F+      ++G +L+      +P  VF V+ ++ + +
Sbjct: 323  FAVWKGFWSGF---FGGLFFLCLFSFLGTGMLYGAYLLKVGIIGSPGDVFIVVMSMLLGA 379

Query: 1775 MSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDT-PTIKGNINMRGVYFAYP 1951
              + L + +    + AR+SA  ++  I +   ID     G   P + G +    V+F YP
Sbjct: 380  YFLGLISPHMMVLLNARVSAATIYQTIDRVPKIDPYSKAGKRLPNVVGRVKFENVHFRYP 439

Query: 1952 NRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLS 2131
            +R+   +L+G N++   G +VALVG SGCGKST++ L+ R Y+   G+V ID +D+R+L+
Sbjct: 440  SRKEAKILNGLNLTVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGTDVRELN 499

Query: 2132 VKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDT 2311
            +  LR+ + +V QEP LFN TI  N+  G    T++++ +   +AN H F+  +P GYDT
Sbjct: 500  IDWLRNVVGIVQQEPILFNDTIHNNLLIGNPGATREKMIEVCKMANAHDFIEKMPKGYDT 559

Query: 2312 SVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTC 2491
             +G  G +LSGGQKQRVAIAR ++RDPKILLLDEATSALD +SE +VQ AL+ A  GRT
Sbjct: 560  LIGDGGVQLSGGQKQRVAIARTLIRDPKILLLDEATSALDAQSESVVQSALNNAAKGRTT 619

Query: 2492 VVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
            ++IAHRLSTI+ ADKI+    G  +E G H+ L+   G Y+ LV+ Q
Sbjct: 620  IMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVHLGGRYFDLVKAQ 666


>gi|72477|pir||DVHY1C multidrug resistance protein 1 - Chinese hamster
 gi|191155|gb|AAA37004.1| p-glycoprotein
          Length = 1276

 Score =  675 bits (1741), Expect = 0.0
 Identities = 377/890 (42%), Positives = 550/890 (61%), Gaps = 12/890 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            +++ILKG++ +V  G+TVALVG+SGCGKST++ LL R Y+   G++ +DG  I+  N+R+
Sbjct: 403  DVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIRTINVRY 462

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  IG+V QEP++F  T+AENIR G   +T  +IE+A K ANA++FI KL  ++DT++G
Sbjct: 463  LREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVG 522

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA EGRTT+ I
Sbjct: 523  ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVI 582

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ----EIERAXXXXXX 709
            AHRLST+RNA  I  FD G+I E+G H+EL+ ++ GIY  +V  Q    EIE
Sbjct: 583  AHRLSTVRNADIIAGFDGGVIVEQGNHEELM-REKGIYFKLVMTQTAGNEIELGNEVGES 641

Query: 710  XXXXXXXXHRSFHRDSVTSDEERELQQSLAR---DSTRLRQSMISTTTQVPXXXXXXXXX 880
                      S  +DS +S   R   +   R   D  R   +  +    VP
Sbjct: 642  KNEIDNLDMSS--KDSASSLIRRRSTRRSIRGPHDQDRKLSTKEALDEDVP--------- 690

Query: 881  XXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDD 1060
                      S + I K  S E    ++ +   ++ G   PAFSI++ ++  + +   DD
Sbjct: 691  --------PISFWRILKLNSSEWPYFVVGIFCAIVNGALQPAFSIIFSKVVGVFTRNTDD 742

Query: 1061 VSIK--ALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFD 1234
             + +  + L SL F++L     I+  + G   GKAGE ++ RLR  VF+++++QD S+FD
Sbjct: 743  ETKRHDSNLFSLLFLILGVISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFD 802

Query: 1235 DSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXX 1414
            + ++  G+LT+RLA DA  V+ A   RLA +   I +L  G+ ++  YGW +  +
Sbjct: 803  NPKNTTGALTTRLANDAGQVKGATGARLAVITQNIANLGTGIIISLIYGWQLTLLLLAIV 862

Query: 1415 XXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASK 1594
                         L  +  +D      + ++ TE+I N++TV +LT+++   + +  + +
Sbjct: 863  PIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFENMYAQSLQ 922

Query: 1595 SPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMAS 1774
             P+R A+ +     ++F+   + + +++A  + FG +L++    T   V  V  A+   +
Sbjct: 923  IPYRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGA 982

Query: 1775 MSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYP 1951
            M+V   +S+ P+Y +A++SA  +  +I +   ID+    G  P T++GN+    V F YP
Sbjct: 983  MAVGQVSSFAPDYAKAKVSASHIIMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEVVFNYP 1042

Query: 1952 NRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLS 2131
             R    VL G N+    GQT+ALVG SGCGKST +QL+ER+YD + G+V +D  ++  L+
Sbjct: 1043 TRPDIPVLQGLNLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEVNQLN 1102

Query: 2132 VKHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGY 2305
            V+ LR ++ +V QEP LF+ +I ENI YG  +  ++QD++E+AA  ANIH F+  LPD Y
Sbjct: 1103 VQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKY 1162

Query: 2306 DTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGR 2485
            +T VG  G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GR
Sbjct: 1163 NTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGR 1222

Query: 2486 TCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            TC+VIAHRLSTIQNAD I+V +NGK  E GTHQ LLA++G+Y+ +V  Q+
Sbjct: 1223 TCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQA 1272



 Score =  342 bits (878), Expect = 2e-92
 Identities = 212/598 (35%), Positives = 322/598 (53%), Gaps = 22/598 (3%)
 Frame = +2

Query: 911  SLFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGD---------- 1057
            S+F +F+YA   +   +++  +  +I G   P   +V+G +    ++ G+
Sbjct: 34   SVFTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLVFGDMTDSFASVGNIPTNATNNAT 93

Query: 1058 -----DVSIKALLNSLWFILLAFTG-GISTLISGSLLGKAGETMSGR----LRMDVFRNI 1207
                 D+  K L   +      +TG G   LI   +        +GR    +R   F  I
Sbjct: 94   QVNASDIFGK-LEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAI 152

Query: 1208 MQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWN 1387
            M Q+  +FD   H+VG L +RL  D   +   I  ++      + + F G  + F  GW
Sbjct: 153  MNQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWK 210

Query: 1388 MAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYM 1567
            +  +                  L     +++ +  +A  +  E ++  +TV A   Q+
Sbjct: 211  LTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKE 270

Query: 1568 YDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQ 1747
             + +    +   R  I + +  ++S   A   +  ++A+A+ +G  L+ +   +   V
Sbjct: 271  LERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLT 330

Query: 1748 VIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNIN 1924
            V  A+ +A  S+  A+     +  AR +A  +F +I  K  ID+    G  P  IKGN+
Sbjct: 331  VFFAVLIAPFSIGQASPNIEAFANARGAAYEIFNIIDNKPSIDSFSKNGYKPDNIKGNLE 390

Query: 1925 MRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKI 2104
             + ++F+YP+R+   +L G N+    GQTVALVG SGCGKSTT+QL++R YD   G V I
Sbjct: 391  FKNIHFSYPSRKDVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGVVSI 450

Query: 2105 DDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFV 2284
            D  DIR ++V++LR+ I +V QEP LF  TI ENI YG EN+T D++EKA   AN + F+
Sbjct: 451  DGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFI 510

Query: 2285 MGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEAL 2464
            M LP  +DT VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +VQ AL
Sbjct: 511  MKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAAL 570

Query: 2465 DKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
            DKAR GRT +VIAHRLST++NAD I     G  +E+G H+ L+  +G+Y++LV  Q++
Sbjct: 571  DKAREGRTTIVIAHRLSTVRNADIIAGFDGGVIVEQGNHEELMREKGIYFKLVMTQTA 628


>gi|126924|sp|P21448|MDR1_CRIGR Multidrug resistance protein 1
            (P-glycoprotein 1)
 gi|191165|gb|AAA68883.1| p-glycoprotein isoform I
          Length = 1276

 Score =  675 bits (1741), Expect = 0.0
 Identities = 377/890 (42%), Positives = 550/890 (61%), Gaps = 12/890 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            +++ILKG++ +V  G+TVALVG+SGCGKST++ LL R Y+   G++ +DG  I+  N+R+
Sbjct: 403  DVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIRTINVRY 462

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  IG+V QEP++F  T+AENIR G   +T  +IE+A K ANA++FI KL  ++DT++G
Sbjct: 463  LREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVG 522

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA EGRTT+ I
Sbjct: 523  ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVI 582

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ----EIERAXXXXXX 709
            AHRLST+RNA  I  FD G+I E+G H+EL+ ++ GIY  +V  Q    EIE
Sbjct: 583  AHRLSTVRNADIIAGFDGGVIVEQGNHEELM-REKGIYFKLVMTQTAGNEIELGNEVGES 641

Query: 710  XXXXXXXXHRSFHRDSVTSDEERELQQSLAR---DSTRLRQSMISTTTQVPXXXXXXXXX 880
                      S  +DS +S   R   +   R   D  R   +  +    VP
Sbjct: 642  KNEIDNLDMSS--KDSASSLIRRRSTRRSIRGPHDQDRKLSTKEALDEDVP--------- 690

Query: 881  XXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDD 1060
                      S + I K  S E    ++ +   ++ G   PAFSI++ ++  + +   DD
Sbjct: 691  --------PISFWRILKLNSSEWPYFVVGIFCAIVNGALQPAFSIIFSKVVGVFTRNTDD 742

Query: 1061 VSIK--ALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFD 1234
             + +  + L SL F++L     I+  + G   GKAGE ++ RLR  VF+++++QD S+FD
Sbjct: 743  ETKRHDSNLFSLLFLILGVISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFD 802

Query: 1235 DSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXX 1414
            + ++  G+LT+RLA DA  V+ A   RLA +   I +L  G+ ++  YGW +  +
Sbjct: 803  NPKNTTGALTTRLANDAGQVKGATGARLAVITQNIANLGTGIIISLIYGWQLTLLLLAIV 862

Query: 1415 XXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASK 1594
                         L  +  +D      + ++ TE+I N++TV +LT+++   + +  + +
Sbjct: 863  PIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFENMYAQSLQ 922

Query: 1595 SPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMAS 1774
             P+R A+ +     ++F+   + + +++A  + FG +L++    T   V  V  A+   +
Sbjct: 923  IPYRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGA 982

Query: 1775 MSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYP 1951
            M+V   +S+ P+Y +A++SA  +  +I +   ID+    G  P T++GN+    V F YP
Sbjct: 983  MAVGQVSSFAPDYAKAKVSASHIIMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEVVFNYP 1042

Query: 1952 NRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLS 2131
             R    VL G N+    GQT+ALVG SGCGKST +QL+ER+YD + G+V +D  ++  L+
Sbjct: 1043 TRPDIPVLQGLNLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEVNQLN 1102

Query: 2132 VKHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGY 2305
            V+ LR ++ +V QEP LF+ +I ENI YG  +  ++QD++E+AA  ANIH F+  LPD Y
Sbjct: 1103 VQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKY 1162

Query: 2306 DTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGR 2485
            +T VG  G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GR
Sbjct: 1163 NTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGR 1222

Query: 2486 TCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            TC+VIAHRLSTIQNAD I+V +NGK  E GTHQ LLA++G+Y+ +V  Q+
Sbjct: 1223 TCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQA 1272



 Score =  342 bits (876), Expect = 4e-92
 Identities = 211/598 (35%), Positives = 322/598 (53%), Gaps = 22/598 (3%)
 Frame = +2

Query: 911  SLFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGD---------- 1057
            S+F +F+YA   +   +++  +  +I G   P   +V+G +    ++ G+
Sbjct: 34   SVFTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLVFGDMTDSFASVGNIPTNATNNAT 93

Query: 1058 -----DVSIKALLNSLWFILLAFTG-GISTLISGSLLGKAGETMSGR----LRMDVFRNI 1207
                 D+  K L   +      +TG G   LI   +        +GR    +R   F  I
Sbjct: 94   QVNASDIFGK-LEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAI 152

Query: 1208 MQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWN 1387
            M Q+  +FD   H+VG L +RL  D   +   I  ++      + + F G  + F  GW
Sbjct: 153  MNQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWK 210

Query: 1388 MAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYM 1567
            +  +                  L     +++ +  +A  +  E ++  +TV A   Q+
Sbjct: 211  LTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKE 270

Query: 1568 YDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQ 1747
             + +    +   R  I + +  ++S   A   +  ++A+A+ +G  L+ +   +   V
Sbjct: 271  LERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLT 330

Query: 1748 VIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNIN 1924
            V  A+ + + S+  A+     +  AR +A  +F +I  K  ID+    G  P  IKGN+
Sbjct: 331  VFFAVLIGAFSIGQASPNIEAFANARGAAYEIFNIIDNKPSIDSFSKNGYKPDNIKGNLE 390

Query: 1925 MRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKI 2104
             + ++F+YP+R+   +L G N+    GQTVALVG SGCGKSTT+QL++R YD   G V I
Sbjct: 391  FKNIHFSYPSRKDVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGVVSI 450

Query: 2105 DDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFV 2284
            D  DIR ++V++LR+ I +V QEP LF  TI ENI YG EN+T D++EKA   AN + F+
Sbjct: 451  DGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFI 510

Query: 2285 MGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEAL 2464
            M LP  +DT VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +VQ AL
Sbjct: 511  MKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAAL 570

Query: 2465 DKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
            DKAR GRT +VIAHRLST++NAD I     G  +E+G H+ L+  +G+Y++LV  Q++
Sbjct: 571  DKAREGRTTIVIAHRLSTVRNADIIAGFDGGVIVEQGNHEELMREKGIYFKLVMTQTA 628


>gi|191157|gb|AAA37005.1| p-glycoprotein
          Length = 1169

 Score =  675 bits (1741), Expect = 0.0
 Identities = 377/890 (42%), Positives = 550/890 (61%), Gaps = 12/890 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            +++ILKG++ +V  G+TVALVG+SGCGKST++ LL R Y+   G++ +DG  I+  N+R+
Sbjct: 296  DVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIRTINVRY 355

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  IG+V QEP++F  T+AENIR G   +T  +IE+A K ANA++FI KL  ++DT++G
Sbjct: 356  LREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVG 415

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA EGRTT+ I
Sbjct: 416  ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVI 475

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ----EIERAXXXXXX 709
            AHRLST+RNA  I  FD G+I E+G H+EL+ ++ GIY  +V  Q    EIE
Sbjct: 476  AHRLSTVRNADIIAGFDGGVIVEQGNHEELM-REKGIYFKLVMTQTAGNEIELGNEVGES 534

Query: 710  XXXXXXXXHRSFHRDSVTSDEERELQQSLAR---DSTRLRQSMISTTTQVPXXXXXXXXX 880
                      S  +DS +S   R   +   R   D  R   +  +    VP
Sbjct: 535  KNEIDNLDMSS--KDSASSLIRRRSTRRSIRGPHDQDRKLSTKEALDEDVP--------- 583

Query: 881  XXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDD 1060
                      S + I K  S E    ++ +   ++ G   PAFSI++ ++  + +   DD
Sbjct: 584  --------PISFWRILKLNSSEWPYFVVGIFCAIVNGALQPAFSIIFSKVVGVFTRNTDD 635

Query: 1061 VSIK--ALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFD 1234
             + +  + L SL F++L     I+  + G   GKAGE ++ RLR  VF+++++QD S+FD
Sbjct: 636  ETKRHDSNLFSLLFLILGVISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFD 695

Query: 1235 DSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXX 1414
            + ++  G+LT+RLA DA  V+ A   RLA +   I +L  G+ ++  YGW +  +
Sbjct: 696  NPKNTTGALTTRLANDAGQVKGATGARLAVITQNIANLGTGIIISLIYGWQLTLLLLAIV 755

Query: 1415 XXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASK 1594
                         L  +  +D      + ++ TE+I N++TV +LT+++   + +  + +
Sbjct: 756  PIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFENMYAQSLQ 815

Query: 1595 SPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMAS 1774
             P+R A+ +     ++F+   + + +++A  + FG +L++    T   V  V  A+   +
Sbjct: 816  IPYRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGA 875

Query: 1775 MSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYP 1951
            M+V   +S+ P+Y +A++SA  +  +I +   ID+    G  P T++GN+    V F YP
Sbjct: 876  MAVGQVSSFAPDYAKAKVSASHIIMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEVVFNYP 935

Query: 1952 NRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLS 2131
             R    VL G N+    GQT+ALVG SGCGKST +QL+ER+YD + G+V +D  ++  L+
Sbjct: 936  TRPDIPVLQGLNLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEVNQLN 995

Query: 2132 VKHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGY 2305
            V+ LR ++ +V QEP LF+ +I ENI YG  +  ++QD++E+AA  ANIH F+  LPD Y
Sbjct: 996  VQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKY 1055

Query: 2306 DTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGR 2485
            +T VG  G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GR
Sbjct: 1056 NTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGR 1115

Query: 2486 TCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            TC+VIAHRLSTIQNAD I+V +NGK  E GTHQ LLA++G+Y+ +V  Q+
Sbjct: 1116 TCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQA 1165



 Score =  340 bits (873), Expect = 8e-92
 Identities = 191/488 (39%), Positives = 282/488 (57%), Gaps = 1/488 (0%)
 Frame = +2

Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
            ++R   F  IM Q+  +FD   H+VG L +RL  D   +   I  ++      + + F G
Sbjct: 36   KIRQKFFHAIMNQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGG 93

Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
              + F  GW +  +                  L     +++ +  +A  +  E ++  +T
Sbjct: 94   FIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRT 153

Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
            V A   Q+   + +    +   R  I + +  ++S   A   +  ++A+A+ +G  L+ +
Sbjct: 154  VIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVIS 213

Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
               +   V  V  A+ +A  S+  A+     +  AR +A  +F +I  K  ID+    G
Sbjct: 214  KEYSIGQVLTVFFAVLIAPFSIGQASPNIEAFANARGAAYEIFNIIDNKPSIDSFSKNGY 273

Query: 1898 TP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
             P  IKGN+  + ++F+YP+R+   +L G N+    GQTVALVG SGCGKSTT+QL++R
Sbjct: 274  KPDNIKGNLEFKNIHFSYPSRKDVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRL 333

Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
            YD   G V ID  DIR ++V++LR+ I +V QEP LF  TI ENI YG EN+T D++EKA
Sbjct: 334  YDPTEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKA 393

Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
               AN + F+M LP  +DT VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDT
Sbjct: 394  VKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 453

Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
            ESE +VQ ALDKAR GRT +VIAHRLST++NAD I     G  +E+G H+ L+  +G+Y+
Sbjct: 454  ESEAVVQAALDKAREGRTTIVIAHRLSTVRNADIIAGFDGGVIVEQGNHEELMREKGIYF 513

Query: 2615 RLVEKQSS 2638
            +LV  Q++
Sbjct: 514  KLVMTQTA 521


>gi|39595370|emb|CAE60408.1| Hypothetical protein CBG04013
            [Caenorhabditis briggsae]
          Length = 1265

 Score =  673 bits (1737), Expect = 0.0
 Identities = 369/879 (41%), Positives = 531/879 (59%), Gaps = 2/879 (0%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            ++ +LKG+S EV  GE +ALVG SGCGKST + LL RFY+   G + +DG+ ++E N+
Sbjct: 406  DIPVLKGISLEVKSGEKIALVGSSGCGKSTIVNLLQRFYDPTKGKVSIDGVDLKEINVHS 465

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  IGIV QEP++F  T+ ENI+MG+   T   + EACKMANA++FI +L D Y T +G
Sbjct: 466  LREQIGIVSQEPVLFDGTIYENIKMGNEHATHDQVVEACKMANANDFIKRLPDGYGTRVG 525

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
               VQLSGGQKQR+AIARA+V+ P+ILLLDEATSALDTE+ER VQ ALD+A  GRTTL +
Sbjct: 526  EKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQAALDQAQAGRTTLIV 585

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
            AHRLSTIRN  KI VF  G I E G+H+EL++K  G++  M +AQ + +
Sbjct: 586  AHRLSTIRNVDKIFVFKAGNIVETGSHEELMNK-QGVFYDMTQAQVVRQQQQEAGKDI-- 642

Query: 722  XXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXXXXGA 901
                      D+++      L +   + STR   SM ++  Q+                A
Sbjct: 643  ---------EDTISESAHSHLSR---KSSTRSAISMATSIHQL--------AEEVEECKA 682

Query: 902  MEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALL 1081
                +  IF +   ++   I  +    I G   P F++VY ++F + S   + +
Sbjct: 683  PPTPISKIFNFNRDKIWWFIGGMFGAFIFGSVTPVFALVYAEIFNVYSEPVEQMQSDVYF 742

Query: 1082 NSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSL 1261
                F+L+  T  I   IS + LG+ GE+++ +LR + F+N+M+QD +++DD RH  G L
Sbjct: 743  WCGMFVLMGITFFIGFFISANCLGRCGESLTMKLRFEAFKNLMRQDIAFYDDLRHGTGKL 802

Query: 1262 TSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXXX 1441
             +R ATDAPNV+  +  RL  VL  IV++   +G+ FYYGW +A I
Sbjct: 803  CTRFATDAPNVR-YVFTRLPVVLASIVTILGALGIGFYYGWQLALI-LVVMVPLLVMGGY 860

Query: 1442 XXXYLKFRGQ-RDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIV 1618
                ++F  Q RD     EA ++ ++++ + +TV +L +QE  +  +    + P    +
Sbjct: 861  FEMQMRFGKQIRDTQLLEEAGKVASQAVEHIRTVHSLNRQEQFHFTYCEYLREPFNTNLK 920

Query: 1619 RGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAAS 1798
                    FA + S + + +A+A+  G   ++ +   P  V++V  A++     +    S
Sbjct: 921  HAHTYGAVFAFSQSLIFFMYAVAFYLGSIFVNQHSMQPIDVYRVFFAISFCGQMIGNTTS 980

Query: 1799 YFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVLD 1978
            + P+ V+AR++A ++F +I   + ID+    G    I GNI++R ++F YP R+   VL
Sbjct: 981  FIPDVVKARLAASLLFYLIEHPTPIDSLSEAGIVKPITGNISIRNIFFNYPTRKETKVLQ 1040

Query: 1979 GFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIA 2158
            GF +    GQTVALVG SGCGKST + L+ER+Y+   G + ID  +IR+L++  LR  +
Sbjct: 1041 GFTIDIKPGQTVALVGHSGCGKSTIMGLLERFYNQDKGMIMIDGDNIRNLNISSLRQQVC 1100

Query: 2159 LVGQEPTLFNLTIRENITYGL-ENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGR 2335
            +V QEPTLF+ TI ENI YG   N+T  ++ +AA +ANIH F++GLPDGYDT VG  G +
Sbjct: 1101 IVSQEPTLFDCTIGENICYGTNRNVTYQEIVEAAKMANIHNFILGLPDGYDTHVGEKGTQ 1160

Query: 2336 LSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLS 2515
            LSGGQKQR+AIARA+VR P +LLLDEATSALDTESEKIVQEALD A+ GRTC+VIAHRLS
Sbjct: 1161 LSGGQKQRIAIARALVRSPSVLLLDEATSALDTESEKIVQEALDAAKQGRTCLVIAHRLS 1220

Query: 2516 TIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
            TIQN+D I +   GK +++GTH  L+ +  +Y +L E Q
Sbjct: 1221 TIQNSDVIAIVSEGKIVDKGTHDELMRKSEIYQKLCETQ 1259



 Score =  325 bits (834), Expect = 3e-87
 Identities = 192/596 (32%), Positives = 325/596 (54%), Gaps = 24/596 (4%)
 Frame = +2

Query: 917  FDIFKYA-SPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKI---------------LSA 1048
            + +F Y    ++  +I+  +  +I G  +P  +IV G +  +               ++
Sbjct: 36   YGLFSYTRGKDLILLIVGTIAAVIHGAGFPLLAIVLGGMTTVFLRAQNSDFVVGVGNVNP 95

Query: 1049 GG------DDVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIM 1210
             G      D+ + + +   +++++L     +++ +  +      E +  +LR +  + I+
Sbjct: 96   NGLEPISIDEFNSEVVKYCIYYLILGVAMFVTSYVQIACFESYAENLVHKLRQNYLKAIL 155

Query: 1211 QQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNM 1390
            +Q   +FD  +   G+LT+RL  D   V+  +  + A ++    +   G GV F+Y W+M
Sbjct: 156  RQQIQWFD--KQQTGNLTARLTDDLERVREGLGDKFALLVQMFAAFLAGYGVGFFYSWSM 213

Query: 1391 APIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMY 1570
              +                  +  R + + ++   A  +  E+ S+ +TV +L   +
Sbjct: 214  TLVMMGFAPLIVLSGAKMSKSMATRTKVEQETYAVAGAIAEETFSSIRTVHSLNGHKREL 273

Query: 1571 DAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPY-TVFQ 1747
            D F  A ++  +  IV+  +  +    +   +  ++A+A+ +G  LI N+ +     +F
Sbjct: 274  DRFWNALENGRKTGIVKYCYMGIGVGFSNLCMYSSYALAFWYGSTLIINDPTFDRGLIFT 333

Query: 1748 VIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD-TPTIKGNIN 1924
            V  A+   S S+  A  +   +  AR +A  +  +I     ID   L G     +KG+I+
Sbjct: 334  VFFAVLSGSTSLGGALPHLASFGTARGAAYTVLRVINSHPKIDPYSLEGLLVDNMKGDIS 393

Query: 1925 MRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKI 2104
             + V+F YP+R+   VL G ++    G+ +ALVG SGCGKST + L++R+YD   G V I
Sbjct: 394  FQNVHFRYPSRKDIPVLKGISLEVKSGEKIALVGSSGCGKSTIVNLLQRFYDPTKGKVSI 453

Query: 2105 DDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFV 2284
            D  D+++++V  LR+ I +V QEP LF+ TI ENI  G E+ T DQV +A  +AN + F+
Sbjct: 454  DGVDLKEINVHSLREQIGIVSQEPVLFDGTIYENIKMGNEHATHDQVVEACKMANANDFI 513

Query: 2285 MGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEAL 2464
              LPDGY T VG  G +LSGGQKQR+AIARA+V++PKILLLDEATSALDTE+E+ VQ AL
Sbjct: 514  KRLPDGYGTRVGEKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQAAL 573

Query: 2465 DKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
            D+A+ GRT +++AHRLSTI+N DKI V + G  +E G+H+ L+ ++G++Y + + Q
Sbjct: 574  DQAQAGRTTLIVAHRLSTIRNVDKIFVFKAGNIVETGSHEELMNKQGVFYDMTQAQ 629


>gi|22759019|gb|AAN05645.1| multidrug resistance p-glycoprotein [Canis
            familiaris]
          Length = 1281

 Score =  673 bits (1737), Expect = 0.0
 Identities = 377/889 (42%), Positives = 547/889 (61%), Gaps = 11/889 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            E+KILKG++ +V  G+TVALVG+SGCGKST++ L+ R Y+   GM+ +DG  I+  N+R
Sbjct: 408  EVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTDGMVCIDGQDIRTINVRH 467

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR   G+V QEP++F  T+AENIR G   +T  +IE+A K ANA++FI KL +++DT++G
Sbjct: 468  LREITGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPNKFDTLVG 527

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA +GRTT+ I
Sbjct: 528  ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVI 587

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ------EIERAXXXX 703
            AHRLST+RNA  I  FD G+I E+G HDEL+ K+ GIY  +V  Q      E+E A
Sbjct: 588  AHRLSTVRNADVIAGFDDGVIVEKGNHDELM-KEKGIYFKLVTMQTRGNEIELENATG-- 644

Query: 704  XXXXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXX 883
                            +S +  +  E+    +  S   R+S   +
Sbjct: 645  ----------------ESKSESDALEMSPKDSGSSLIKRRSTRRSIHAPQGQDRKLGTKE 688

Query: 884  XXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV 1063
                     S + I K  S E    ++ +   +I G   PAFSI++ ++  I +   D
Sbjct: 689  DLNENVPPVSFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSIIFSRIIGIFTRDEDPE 748

Query: 1064 SIKALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDD 1237
            + +   N  S+ F++L     I+  + G   GKAGE ++ RLR  VFR++++QD S+FDD
Sbjct: 749  TKRQNSNMFSVLFLVLGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDD 808

Query: 1238 SRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXX 1417
             ++  G+LT+RLA DA  V+ AI  RLA +   I +L  G+ ++  YGW +  +
Sbjct: 809  PKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVP 868

Query: 1418 XXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKS 1597
                        L  +  +D      A ++ TE+I N++TV +LT+++     +  + +
Sbjct: 869  IIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTREQKFEYMYAQSLQV 928

Query: 1598 PHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASM 1777
            P+R ++ +     +SF++  + + +++A  + FG +L++N +     V  V  A+   +M
Sbjct: 929  PYRNSLRKAHIFGVSFSITQAMMYFSYAGCFRFGAYLVANEFMNFQDVLLVFSAIVFGAM 988

Query: 1778 SVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYPN 1954
            +V   +S+ P+Y +A++SA  +  +I +  +ID+    G  P T++GN+    V F YP
Sbjct: 989  AVGQVSSFAPDYAKAKVSAAHVIMIIEKSPLIDSYSPHGLKPNTLEGNVTFNEVVFNYPT 1048

Query: 1955 RRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSV 2134
            R    VL G ++    GQT+ALVG SGCGKST +QL+ER+YD L GSV ID  +I+ L+V
Sbjct: 1049 RPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGSVLIDGKEIKHLNV 1108

Query: 2135 KHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYD 2308
            + LR ++ +V QEP LF+ +I ENI YG  +  ++ +++ +AA  ANIH F+  LP+ Y+
Sbjct: 1109 QWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIMQAAKEANIHHFIETLPEKYN 1168

Query: 2309 TSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRT 2488
            T VG  G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GRT
Sbjct: 1169 TRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRT 1228

Query: 2489 CVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            C+VIAHRLSTIQNAD I+V +NGK  E GTHQ LLA++G+Y+ +V  Q+
Sbjct: 1229 CIVIAHRLSTIQNADLIVVFQNGKVKEHGTHQQLLAQKGIYFSMVSVQA 1277



 Score =  340 bits (871), Expect = 1e-91
 Identities = 191/487 (39%), Positives = 283/487 (57%), Gaps = 1/487 (0%)
 Frame = +2

Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
            ++R   F  IM+Q+  +FD   H+VG L +RL  D   +   I  ++      I + F G
Sbjct: 148  KIRKQFFHAIMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFHSIATFFTG 205

Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
              V F  GW +  +                  L     +++ +  +A  +  E ++  +T
Sbjct: 206  FIVGFTRGWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAYAKAGAVAEEVLAAIRT 265

Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
            V A   Q+   + +    +      I + +  ++S   A   +  ++A+A+ +G  L+ +
Sbjct: 266  VIAFGGQKKELERYNKNLEEAKGIGIKKAITANISIGAAFLLIYASYALAFWYGTSLVLS 325

Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
            +  +   V  V  ++ + + S+  A+     +  AR +A  +F +I  K  ID+   +G
Sbjct: 326  SEYSIGQVLTVFFSVLIGAFSIGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGH 385

Query: 1898 TP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
             P  IKGN+  + V+F+YP+R+   +L G N+    GQTVALVG SGCGKSTT+QL++R
Sbjct: 386  KPDNIKGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRL 445

Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
            YD   G V ID  DIR ++V+HLR+   +V QEP LF  TI ENI YG EN+T D++EKA
Sbjct: 446  YDPTDGMVCIDGQDIRTINVRHLREITGVVSQEPVLFATTIAENIRYGRENVTMDEIEKA 505

Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
               AN + F+M LP+ +DT VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDT
Sbjct: 506  VKEANAYDFIMKLPNKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 565

Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
            ESE +VQ ALDKAR GRT +VIAHRLST++NAD I    +G  +E+G H  L+  +G+Y+
Sbjct: 566  ESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYF 625

Query: 2615 RLVEKQS 2635
            +LV  Q+
Sbjct: 626  KLVTMQT 632


>gi|46394982|gb|AAS91647.1| multidrug resistance protein 1;
            P-glycoprotein [Canis familiaris]
          Length = 1281

 Score =  673 bits (1737), Expect = 0.0
 Identities = 377/889 (42%), Positives = 547/889 (61%), Gaps = 11/889 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            E+KILKG++ +V  G+TVALVG+SGCGKST++ L+ R Y+   GM+ +DG  I+  N+R
Sbjct: 408  EVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTDGMVCIDGQDIRTINVRH 467

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR   G+V QEP++F  T+AENIR G   +T  +IE+A K ANA++FI KL +++DT++G
Sbjct: 468  LREITGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPNKFDTLVG 527

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA +GRTT+ I
Sbjct: 528  ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVI 587

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ------EIERAXXXX 703
            AHRLST+RNA  I  FD G+I E+G HDEL+ K+ GIY  +V  Q      E+E A
Sbjct: 588  AHRLSTVRNADVIAGFDDGVIVEKGNHDELM-KEKGIYFKLVTMQTRGNEIELENATG-- 644

Query: 704  XXXXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXX 883
                            +S +  +  E+    +  S   R+S   +
Sbjct: 645  ----------------ESKSESDALEMSPKDSGSSLIKRRSTRRSIHAPQGQDRKLGTKE 688

Query: 884  XXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV 1063
                     S + I K  S E    ++ +   +I G   PAFSI++ ++  I +   D
Sbjct: 689  DLNENVPPVSFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSIIFSRIIGIFTRDEDPE 748

Query: 1064 SIKALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDD 1237
            + +   N  S+ F++L     I+  + G   GKAGE ++ RLR  VFR++++QD S+FDD
Sbjct: 749  TKRQNSNMFSVLFLVLGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDD 808

Query: 1238 SRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXX 1417
             ++  G+LT+RLA DA  V+ AI  RLA +   I +L  G+ ++  YGW +  +
Sbjct: 809  PKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVP 868

Query: 1418 XXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKS 1597
                        L  +  +D      A ++ TE+I N++TV +LT+++     +  + +
Sbjct: 869  IIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTREQKFEYMYAQSLQV 928

Query: 1598 PHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASM 1777
            P+R ++ +     +SF++  + + +++A  + FG +L++N +     V  V  A+   +M
Sbjct: 929  PYRNSLRKAHIFGVSFSITQAMMYFSYAGCFRFGAYLVANEFMNFQDVLLVFSAIVFGAM 988

Query: 1778 SVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYPN 1954
            +V   +S+ P+Y +A++SA  +  +I +  +ID+    G  P T++GN+    V F YP
Sbjct: 989  AVGQVSSFAPDYAKAKVSAAHVIMIIEKSPLIDSYSPHGLKPNTLEGNVTFNEVVFNYPT 1048

Query: 1955 RRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSV 2134
            R    VL G ++    GQT+ALVG SGCGKST +QL+ER+YD L GSV ID  +I+ L+V
Sbjct: 1049 RPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGSVLIDGKEIKHLNV 1108

Query: 2135 KHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYD 2308
            + LR ++ +V QEP LF+ +I ENI YG  +  ++ +++ +AA  ANIH F+  LP+ Y+
Sbjct: 1109 QWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIVQAAKEANIHHFIETLPEKYN 1168

Query: 2309 TSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRT 2488
            T VG  G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GRT
Sbjct: 1169 TRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRT 1228

Query: 2489 CVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            C+VIAHRLSTIQNAD I+V +NGK  E GTHQ LLA++G+Y+ +V  Q+
Sbjct: 1229 CIVIAHRLSTIQNADLIVVFQNGKVKEHGTHQQLLAQKGIYFSMVSVQA 1277



 Score =  343 bits (879), Expect = 2e-92
 Identities = 192/487 (39%), Positives = 284/487 (57%), Gaps = 1/487 (0%)
 Frame = +2

Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
            ++R   F  IM+Q+  +FD   H+VG L +RL  D   +   I  ++      I + F G
Sbjct: 148  KIRKQFFHAIMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQSIATFFTG 205

Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
              V F  GW +  +                  L     +++ +  +A  +  E ++  +T
Sbjct: 206  FIVGFTRGWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAYAKAGAVAEEVLAAIRT 265

Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
            V A   Q+   + +    +   R  I + +  ++S   A   +  ++A+A+ +G  L+ +
Sbjct: 266  VIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTSLVLS 325

Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
            +  +   V  V  ++ + + S+  A+     +  AR +A  +F +I  K  ID+   +G
Sbjct: 326  SEYSIGQVLTVFFSVLIGAFSIGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGH 385

Query: 1898 TP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
             P  IKGN+  + V+F+YP+R+   +L G N+    GQTVALVG SGCGKSTT+QL++R
Sbjct: 386  KPDNIKGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRL 445

Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
            YD   G V ID  DIR ++V+HLR+   +V QEP LF  TI ENI YG EN+T D++EKA
Sbjct: 446  YDPTDGMVCIDGQDIRTINVRHLREITGVVSQEPVLFATTIAENIRYGRENVTMDEIEKA 505

Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
               AN + F+M LP+ +DT VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDT
Sbjct: 506  VKEANAYDFIMKLPNKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 565

Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
            ESE +VQ ALDKAR GRT +VIAHRLST++NAD I    +G  +E+G H  L+  +G+Y+
Sbjct: 566  ESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYF 625

Query: 2615 RLVEKQS 2635
            +LV  Q+
Sbjct: 626  KLVTMQT 632


>gi|8926217|gb|AAF81747.1| his-tagged-multidrug resistance
            glycoprotein MDR1 [synthetic construct]
          Length = 1287

 Score =  673 bits (1736), Expect = 0.0
 Identities = 376/889 (42%), Positives = 547/889 (61%), Gaps = 11/889 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            E+KILKG++ +V  G+TVALVG+SGCGKST++ L+ R Y+   GM+ +DG  I+  N+R
Sbjct: 414  EVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTDGMVCIDGQDIRTINVRH 473

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR   G+V QEP++F  T+AENIR G   +T  +IE+A K ANA++FI KL +++DT++G
Sbjct: 474  LREITGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPNKFDTLVG 533

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA +GRTT+ I
Sbjct: 534  ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVI 593

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ------EIERAXXXX 703
            AHRLST+RNA  I  FD G+I E+G HDEL+ K+ GIY  +V  Q      E+E A
Sbjct: 594  AHRLSTVRNADVIAGFDDGVIVEKGNHDELM-KEKGIYFKLVTMQTRGNEIELENATG-- 650

Query: 704  XXXXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXX 883
                            +S +  +  E+    +  S   R+S   +
Sbjct: 651  ----------------ESKSESDALEMSPKDSGSSLIKRRSTRRSIHAPQGQDRKLGTKE 694

Query: 884  XXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV 1063
                     S + I K  S E    ++ +   +I G   PAFSI++ ++  I +   D
Sbjct: 695  DLNENVPPVSFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSIIFSRIIGIFTRDEDPE 754

Query: 1064 SIKALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDD 1237
            + +   N  S+ F++L     I+  + G   GKAGE ++ RLR  VFR++++QD S+FDD
Sbjct: 755  TKRQNSNMFSVLFLVLGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDD 814

Query: 1238 SRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXX 1417
             ++  G+LT+RLA DA  V+ AI  RLA +   I +L  G+ ++  YGW +  +
Sbjct: 815  PKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVP 874

Query: 1418 XXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKS 1597
                        L  +  +D      A ++ TE+I N++TV +LT+++     +  + +
Sbjct: 875  IIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTREQKFEYMYAQSLQV 934

Query: 1598 PHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASM 1777
            P+R ++ +     +SF++  + + +++A  + FG +L++N +     V  V  A+   +M
Sbjct: 935  PYRNSLRKAHIFGVSFSITQAMMYFSYAGCFRFGAYLVANEFMNFQDVLLVFSAIVFGAM 994

Query: 1778 SVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYPN 1954
            +V   +S+ P+Y +A++SA  +  +I +  +ID+    G  P T++GN+    V F YP
Sbjct: 995  AVGQVSSFAPDYAKAKVSAAHVIMIIEKSPLIDSYSPHGLKPNTLEGNVTFNEVVFNYPT 1054

Query: 1955 RRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSV 2134
            R    VL G ++    GQT+ALVG SGCGKST +QL+ER+YD L GSV ID  +I+ L+V
Sbjct: 1055 RPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGSVLIDGKEIKHLNV 1114

Query: 2135 KHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYD 2308
            + LR ++ +V QEP LF+ +I ENI YG  +  ++ +++ +AA  ANIH F+  LP+ Y+
Sbjct: 1115 QWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIMQAAKEANIHHFIETLPEKYN 1174

Query: 2309 TSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRT 2488
            T VG  G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GRT
Sbjct: 1175 TRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRT 1234

Query: 2489 CVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            C+VIAHRLSTIQNAD I+V +NGK  E GTHQ LLA++G+Y+ ++  Q+
Sbjct: 1235 CIVIAHRLSTIQNADLIVVFQNGKVKEHGTHQQLLAQKGIYFSMISVQA 1283



 Score =  343 bits (879), Expect = 2e-92
 Identities = 192/487 (39%), Positives = 284/487 (57%), Gaps = 1/487 (0%)
 Frame = +2

Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
            ++R   F  IM+Q+  +FD   H+VG L +RL  D   +   I  ++      I + F G
Sbjct: 154  KIRKQFFHAIMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQSIATFFTG 211

Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
              V F  GW +  +                  L     +++ +  +A  +  E ++  +T
Sbjct: 212  FIVGFTRGWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAYAKAGAVAEEVLAAIRT 271

Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
            V A   Q+   + +    +   R  I + +  ++S   A   +  ++A+A+ +G  L+ +
Sbjct: 272  VIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTSLVLS 331

Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
            +  +   V  V  ++ + + S+  A+     +  AR +A  +F +I  K  ID+   +G
Sbjct: 332  SEYSIGQVLTVFFSVLIGAFSIGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGH 391

Query: 1898 TP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
             P  IKGN+  + V+F+YP+R+   +L G N+    GQTVALVG SGCGKSTT+QL++R
Sbjct: 392  KPDNIKGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRL 451

Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
            YD   G V ID  DIR ++V+HLR+   +V QEP LF  TI ENI YG EN+T D++EKA
Sbjct: 452  YDPTDGMVCIDGQDIRTINVRHLREITGVVSQEPVLFATTIAENIRYGRENVTMDEIEKA 511

Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
               AN + F+M LP+ +DT VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDT
Sbjct: 512  VKEANAYDFIMKLPNKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 571

Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
            ESE +VQ ALDKAR GRT +VIAHRLST++NAD I    +G  +E+G H  L+  +G+Y+
Sbjct: 572  ESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYF 631

Query: 2615 RLVEKQS 2635
            +LV  Q+
Sbjct: 632  KLVTMQT 638


>gi|17508505|ref|NP_491707.1| P-GlycoProtein related (pgp-2)
            [Caenorhabditis elegans]
 gi|15617726|gb|AAB52482.2| P-glycoprotein related protein 2
            [Caenorhabditis elegans]
          Length = 1265

 Score =  672 bits (1735), Expect = 0.0
 Identities = 369/879 (41%), Positives = 531/879 (59%), Gaps = 2/879 (0%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            ++ +LKG+S E+  G+ +ALVG SGCGKST + LL RFY+   G + +DG+ ++E N+
Sbjct: 406  DIHVLKGISLELKAGDKIALVGSSGCGKSTIVNLLQRFYDPTKGRVLIDGVDLREVNVHS 465

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  IGIV QEP++F  T+ ENI+MG+   T   + EACKMANA++FI +L D Y T +G
Sbjct: 466  LREQIGIVSQEPVLFDGTIYENIKMGNEHATHDQVVEACKMANANDFIKRLPDGYGTRVG 525

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
               VQLSGGQKQR+AIARA+V+ P+ILLLDEATSALDTE+ER VQ ALD+A  GRTT+ +
Sbjct: 526  EKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQGALDQAQAGRTTIIV 585

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
            AHRLSTIRN  +I VF  G I E G+H+EL+SK  GI+  M +AQ + +
Sbjct: 586  AHRLSTIRNVDRIFVFKAGNIVESGSHEELMSK-QGIFYDMTQAQVVRQQQQEAGKDI-- 642

Query: 722  XXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXXXXGA 901
                      D+++      L +   + STR   S IS  T +                A
Sbjct: 643  ---------EDTISESAHSHLSR---KSSTR---SAISIATSI-----HQLAEEVEECKA 682

Query: 902  MEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALL 1081
               S+F IFK+   ++   I  +    I G   P F++VY ++F + S   D +
Sbjct: 683  PPTSMFKIFKFNGDKVGWFIGGIFGAFIFGSVTPVFALVYAEIFNVYSLPADQMQANVYF 742

Query: 1082 NSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSL 1261
                F+L+  T  +    S + LG+ GE+++ +LR + F+N+++QD +++DD RH  G L
Sbjct: 743  WCGMFVLMGITFFVGFFTSANCLGRCGESLTMKLRFEAFKNLLRQDIAFYDDLRHGTGKL 802

Query: 1262 TSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXXX 1441
             +R ATDAPNV+  +  RL  VL  IV++   +G+ FYYGW +A I
Sbjct: 803  CTRFATDAPNVR-YVFTRLPVVLASIVTICGALGIGFYYGWQLALI-LVVMVPLLVMGGY 860

Query: 1442 XXXYLKFRGQ-RDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIV 1618
                ++F  Q RD     EA ++ ++++ + +TV +L +QE  +  +    + P    +
Sbjct: 861  FEMQMRFGKQIRDTQLLEEAGKVASQAVEHIRTVHSLNRQEQFHFTYCEYLREPFNTNLK 920

Query: 1619 RGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAAS 1798
                    FA + S + + +A A+  G   ++     P  V++V  A++     +    S
Sbjct: 921  HAHTYGAVFAFSQSLIFFMYAAAFYLGSIFVNQQAMQPIDVYRVFFAISFCGQMIGNTTS 980

Query: 1799 YFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVLD 1978
            + P+ V+AR++A ++F +I   + ID+   +G    I GNI++R V+F YP R+   VL
Sbjct: 981  FIPDVVKARLAASLLFYLIEHPTPIDSLSDSGIVKPITGNISIRNVFFNYPTRKDTKVLQ 1040

Query: 1979 GFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIA 2158
            GF +    G+TVALVG SGCGKST + L+ER+Y+   G + ID  +IR+L++  LR+ +
Sbjct: 1041 GFTLDIKAGKTVALVGHSGCGKSTIMGLLERFYNQDKGMIMIDGDNIRNLNISSLREQVC 1100

Query: 2159 LVGQEPTLFNLTIRENITYGL-ENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGR 2335
            +V QEPTLF+ TI ENI YG   N+T  ++ +AA +ANIH F++GLPDGYDT VG  G +
Sbjct: 1101 IVSQEPTLFDCTIGENICYGTNRNVTYQEIVEAAKMANIHNFILGLPDGYDTHVGEKGTQ 1160

Query: 2336 LSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLS 2515
            LSGGQKQR+AIARA+VR P +LLLDEATSALDTESEKIVQEALD A+ GRTC+VIAHRLS
Sbjct: 1161 LSGGQKQRIAIARALVRSPSVLLLDEATSALDTESEKIVQEALDAAKQGRTCLVIAHRLS 1220

Query: 2516 TIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
            TIQN+D I +   GK +E+GTH  L+ +  +Y +  E Q
Sbjct: 1221 TIQNSDVIAIVSEGKIVEKGTHDELIRKSEIYQKFCETQ 1259



 Score =  323 bits (829), Expect = 1e-86
 Identities = 198/596 (33%), Positives = 324/596 (54%), Gaps = 24/596 (4%)
 Frame = +2

Query: 917  FDIFKYASP-EMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILS--------AGGDDVSI 1069
            + IF Y    ++  +I   V  +I G  +P  +IV G +  +           G D+V+
Sbjct: 36   YGIFYYTQGVDLLLLITGTVAAVIHGAGFPLLAIVLGGMTTVFLRAQNSDFVVGVDNVNP 95

Query: 1070 KALL-------NS------LWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIM 1210
            + L+       NS      +++++L      ++ +  +      E +  +LR +  + I+
Sbjct: 96   EGLVPISLDEFNSEVVKYCIYYLVLGVLMFFTSYVQIACFESYAERLVHKLRQNYLKAIL 155

Query: 1211 QQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNM 1390
            +Q   +FD  +   G+LT+RL  D   V+  +  + A ++    +   G GV F+Y W+M
Sbjct: 156  RQQIQWFD--KQQTGNLTARLTDDLERVREGLGDKFALLVQMFAAFLAGYGVGFFYSWSM 213

Query: 1391 APIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMY 1570
              +                  +  R + + ++   A  +  E+ S+ +TV +L   +
Sbjct: 214  TLVMMGFAPLIVLSGAKMSKSMATRTRVEQETYAVAGAIAEETFSSIRTVHSLNGHKREL 273

Query: 1571 DAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPY-TVFQ 1747
            D F  A +   +  IV+  +  +    +   +  ++A+A+ +G  LI N+ +     +F
Sbjct: 274  DRFYNALEVGRQTGIVKYCYMGIGVGFSNLCMYSSYALAFWYGSTLIINDPTFDRGLIFT 333

Query: 1748 VIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD-TPTIKGNIN 1924
            V  A+   S S+  A  +   +  AR +A  +  +I     ID   L G     +KG+I+
Sbjct: 334  VFFAVLSGSTSLGGALPHLASFGTARGAASTVLRVINSHPKIDPYSLEGILVDNMKGDIS 393

Query: 1925 MRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKI 2104
             + V+F YP+R+   VL G ++    G  +ALVG SGCGKST + L++R+YD   G V I
Sbjct: 394  FKDVHFRYPSRKDIHVLKGISLELKAGDKIALVGSSGCGKSTIVNLLQRFYDPTKGRVLI 453

Query: 2105 DDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFV 2284
            D  D+R+++V  LR+ I +V QEP LF+ TI ENI  G E+ T DQV +A  +AN + F+
Sbjct: 454  DGVDLREVNVHSLREQIGIVSQEPVLFDGTIYENIKMGNEHATHDQVVEACKMANANDFI 513

Query: 2285 MGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEAL 2464
              LPDGY T VG  G +LSGGQKQR+AIARA+V++PKILLLDEATSALDTE+E+ VQ AL
Sbjct: 514  KRLPDGYGTRVGEKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQGAL 573

Query: 2465 DKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
            D+A+ GRT +++AHRLSTI+N D+I V + G  +E G+H+ L++++G++Y + + Q
Sbjct: 574  DQAQAGRTTIIVAHRLSTIRNVDRIFVFKAGNIVESGSHEELMSKQGIFYDMTQAQ 629


>gi|307180|gb|AAA59575.1| P-glycoprotein [Homo sapiens]
          Length = 1280

 Score =  672 bits (1734), Expect = 0.0
 Identities = 374/889 (42%), Positives = 547/889 (61%), Gaps = 11/889 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            E+KILKG++ +V  G+TVALVG+SGCGKST++ L+ R Y+   GM+ +DG  I+  N+R+
Sbjct: 406  EVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRF 465

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  IG+V QEP++F  T+AENIR G   +T  +IE+A K ANA++FI KL  ++DT++G
Sbjct: 466  LREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVG 525

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA +GRTT+ I
Sbjct: 526  ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVI 585

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ------EIERAXXXX 703
            AHRLST+RNA  I  FD G+I E+G HDEL+ K+ GIY  +V  Q      E+E A
Sbjct: 586  AHRLSTVRNADVIAGFDDGVIVEKGNHDELM-KEKGIYFKLVTMQTAGNEVELENAAD-- 642

Query: 704  XXXXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXX 883
                            +S +  +  E+  + +R S   ++S   +
Sbjct: 643  ----------------ESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKE 686

Query: 884  XXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV 1063
                     S + I K    E    ++ +   +I G   PAF+I++ ++  + +   D
Sbjct: 687  ALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPE 746

Query: 1064 SIKALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDD 1237
            + +   N  SL F+ L     I+  + G   GKAGE ++ RLR  VFR++++QD S+FDD
Sbjct: 747  TKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDD 806

Query: 1238 SRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXX 1417
             ++  G+LT+RLA DA  V+ AI  RLA +   I +L  G+ ++F YGW +  +
Sbjct: 807  PKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVP 866

Query: 1418 XXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKS 1597
                        L  +  +D      A ++ TE+I N++TV +LT+++     +  + +
Sbjct: 867  IIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQV 926

Query: 1598 PHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASM 1777
            P+R ++ +     ++F+   + + +++A  + FG +L+++   +   V  V  A+   +M
Sbjct: 927  PYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAM 986

Query: 1778 SVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYPN 1954
            +V   +S+ P+Y +A+ISA  +  +I +  +ID+    G  P T++GN+    V F YP
Sbjct: 987  AVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPT 1046

Query: 1955 RRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSV 2134
            R    VL G ++    GQT+ALVG SGCGKST +QL+ER+YD L G V +D  +I+ L+V
Sbjct: 1047 RPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNV 1106

Query: 2135 KHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYD 2308
            + LR ++ +V QEP LF+ +I ENI YG  +  ++Q+++ +AA  ANIH F+  LP+ Y
Sbjct: 1107 QWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYS 1166

Query: 2309 TSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRT 2488
            T VG  G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GRT
Sbjct: 1167 TKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRT 1226

Query: 2489 CVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            C+VIAHRLSTIQNAD I+V +NG+  E GTHQ LLA++G+Y+ +V  Q+
Sbjct: 1227 CIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1275



 Score =  348 bits (893), Expect = 4e-94
 Identities = 210/599 (35%), Positives = 330/599 (55%), Gaps = 23/599 (3%)
 Frame = +2

Query: 911  SLFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGD------DVSI 1069
            S+F +F+Y++  +   +++  +  +I G   P   +V+G++  I +  G+      +++
Sbjct: 35   SVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITN 94

Query: 1070 KALLNSLWFIL----------LAFTG-GISTLISGSLLGKAGETMSGR----LRMDVFRN 1204
            ++ +N   F +            ++G G   L++  +        +GR    +R   F
Sbjct: 95   RSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHA 154

Query: 1205 IMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGW 1384
            IM+Q+  +FD   H+VG L +RL  D   +   I  ++      + + F G  V F  GW
Sbjct: 155  IMRQEIGWFDV--HDVGELNTRLTDDVSKINEVIGDKIGMFFQSMATFFTGFIVGFTRGW 212

Query: 1385 NMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEY 1564
             +  +                  L     +++ +  +A  +  E ++  +TV A   Q+
Sbjct: 213  KLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKK 272

Query: 1565 MYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVF 1744
              + +    +   R  I + +  ++S   A   +  ++A+A+ +G  L+ +   +   V
Sbjct: 273  ELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVL 332

Query: 1745 QVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNI 1921
             V  ++ + + SV  A+     +  AR +A  +F +I  K  ID+   +G  P  IKGN+
Sbjct: 333  TVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNL 392

Query: 1922 NMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVK 2101
              R V+F+YP+R+   +L G N+    GQTVALVG SGCGKSTT+QL++R YD   G V
Sbjct: 393  EFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVS 452

Query: 2102 IDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTF 2281
            +D  DIR ++V+ LR+ I +V QEP LF  TI ENI YG EN+T D++EKA   AN + F
Sbjct: 453  VDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDF 512

Query: 2282 VMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEA 2461
            +M LP  +DT VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +VQ A
Sbjct: 513  IMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVA 572

Query: 2462 LDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
            LDKAR GRT +VIAHRLST++NAD I    +G  +E+G H  L+  +G+Y++LV  Q++
Sbjct: 573  LDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTA 631


>gi|2506118|sp|P08183|MDR1_HUMAN Multidrug resistance protein 1
            (P-glycoprotein 1) (CD243 antigen)
 gi|1070659|pir||DVHU1 multidrug resistance protein 1 - human
 gi|386862|gb|AAA59576.1| P glycoprotein
          Length = 1280

 Score =  672 bits (1734), Expect = 0.0
 Identities = 374/889 (42%), Positives = 547/889 (61%), Gaps = 11/889 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            E+KILKG++ +V  G+TVALVG+SGCGKST++ L+ R Y+   GM+ +DG  I+  N+R+
Sbjct: 406  EVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRF 465

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  IG+V QEP++F  T+AENIR G   +T  +IE+A K ANA++FI KL  ++DT++G
Sbjct: 466  LREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVG 525

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA +GRTT+ I
Sbjct: 526  ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVI 585

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ------EIERAXXXX 703
            AHRLST+RNA  I  FD G+I E+G HDEL+ K+ GIY  +V  Q      E+E A
Sbjct: 586  AHRLSTVRNADVIAGFDDGVIVEKGNHDELM-KEKGIYFKLVTMQTAGNEVELENAAD-- 642

Query: 704  XXXXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXX 883
                            +S +  +  E+  + +R S   ++S   +
Sbjct: 643  ----------------ESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKE 686

Query: 884  XXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV 1063
                     S + I K    E    ++ +   +I G   PAF+I++ ++  + +   D
Sbjct: 687  ALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPE 746

Query: 1064 SIKALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDD 1237
            + +   N  SL F+ L     I+  + G   GKAGE ++ RLR  VFR++++QD S+FDD
Sbjct: 747  TKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDD 806

Query: 1238 SRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXX 1417
             ++  G+LT+RLA DA  V+ AI  RLA +   I +L  G+ ++F YGW +  +
Sbjct: 807  PKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVP 866

Query: 1418 XXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKS 1597
                        L  +  +D      A ++ TE+I N++TV +LT+++     +  + +
Sbjct: 867  IIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQV 926

Query: 1598 PHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASM 1777
            P+R ++ +     ++F+   + + +++A  + FG +L+++   +   V  V  A+   +M
Sbjct: 927  PYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAM 986

Query: 1778 SVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYPN 1954
            +V   +S+ P+Y +A+ISA  +  +I +  +ID+    G  P T++GN+    V F YP
Sbjct: 987  AVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPT 1046

Query: 1955 RRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSV 2134
            R    VL G ++    GQT+ALVG SGCGKST +QL+ER+YD L G V +D  +I+ L+V
Sbjct: 1047 RPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNV 1106

Query: 2135 KHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYD 2308
            + LR ++ +V QEP LF+ +I ENI YG  +  ++Q+++ +AA  ANIH F+  LP+ Y
Sbjct: 1107 QWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYS 1166

Query: 2309 TSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRT 2488
            T VG  G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GRT
Sbjct: 1167 TKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRT 1226

Query: 2489 CVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            C+VIAHRLSTIQNAD I+V +NG+  E GTHQ LLA++G+Y+ +V  Q+
Sbjct: 1227 CIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1275



 Score =  348 bits (893), Expect = 4e-94
 Identities = 210/599 (35%), Positives = 330/599 (55%), Gaps = 23/599 (3%)
 Frame = +2

Query: 911  SLFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGD------DVSI 1069
            S+F +F+Y++  +   +++  +  +I G   P   +V+G++  I +  G+      +++
Sbjct: 35   SVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITN 94

Query: 1070 KALLNSLWFIL----------LAFTG-GISTLISGSLLGKAGETMSGR----LRMDVFRN 1204
            ++ +N   F +            ++G G   L++  +        +GR    +R   F
Sbjct: 95   RSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHA 154

Query: 1205 IMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGW 1384
            IM+Q+  +FD   H+VG L +RL  D   +   I  ++      + + F G  V F  GW
Sbjct: 155  IMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGW 212

Query: 1385 NMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEY 1564
             +  +                  L     +++ +  +A  +  E ++  +TV A   Q+
Sbjct: 213  KLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKK 272

Query: 1565 MYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVF 1744
              + +    +   R  I + +  ++S   A   +  ++A+A+ +G  L+ +   +   V
Sbjct: 273  ELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVL 332

Query: 1745 QVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNI 1921
             V  ++ + + SV  A+     +  AR +A  +F +I  K  ID+   +G  P  IKGN+
Sbjct: 333  TVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNL 392

Query: 1922 NMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVK 2101
              R V+F+YP+R+   +L G N+    GQTVALVG SGCGKSTT+QL++R YD   G V
Sbjct: 393  EFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVS 452

Query: 2102 IDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTF 2281
            +D  DIR ++V+ LR+ I +V QEP LF  TI ENI YG EN+T D++EKA   AN + F
Sbjct: 453  VDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDF 512

Query: 2282 VMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEA 2461
            +M LP  +DT VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +VQ A
Sbjct: 513  IMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVA 572

Query: 2462 LDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
            LDKAR GRT +VIAHRLST++NAD I    +G  +E+G H  L+  +G+Y++LV  Q++
Sbjct: 573  LDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTA 631


>gi|2353264|gb|AAB69423.1| P-glycoprotein [Homo sapiens]
          Length = 1279

 Score =  672 bits (1734), Expect = 0.0
 Identities = 374/889 (42%), Positives = 547/889 (61%), Gaps = 11/889 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            E+KILKG++ +V  G+TVALVG+SGCGKST++ L+ R Y+   GM+ +DG  I+  N+R+
Sbjct: 405  EVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRF 464

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  IG+V QEP++F  T+AENIR G   +T  +IE+A K ANA++FI KL  ++DT++G
Sbjct: 465  LREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVG 524

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA +GRTT+ I
Sbjct: 525  ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVI 584

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ------EIERAXXXX 703
            AHRLST+RNA  I  FD G+I E+G HDEL+ K+ GIY  +V  Q      E+E A
Sbjct: 585  AHRLSTVRNADVIAGFDDGVIVEKGNHDELM-KEKGIYFKLVTMQTAGNEVELENAAD-- 641

Query: 704  XXXXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXX 883
                            +S +  +  E+  + +R S   ++S   +
Sbjct: 642  ----------------ESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKE 685

Query: 884  XXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV 1063
                     S + I K    E    ++ +   +I G   PAF+I++ ++  + +   D
Sbjct: 686  ALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPE 745

Query: 1064 SIKALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDD 1237
            + +   N  SL F+ L     I+  + G   GKAGE ++ RLR  VFR++++QD S+FDD
Sbjct: 746  TKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDD 805

Query: 1238 SRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXX 1417
             ++  G+LT+RLA DA  V+ AI  RLA +   I +L  G+ ++F YGW +  +
Sbjct: 806  PKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVP 865

Query: 1418 XXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKS 1597
                        L  +  +D      A ++ TE+I N++TV +LT+++     +  + +
Sbjct: 866  IIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQV 925

Query: 1598 PHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASM 1777
            P+R ++ +     ++F+   + + +++A  + FG +L+++   +   V  V  A+   +M
Sbjct: 926  PYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAM 985

Query: 1778 SVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYPN 1954
            +V   +S+ P+Y +A+ISA  +  +I +  +ID+    G  P T++GN+    V F YP
Sbjct: 986  AVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPT 1045

Query: 1955 RRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSV 2134
            R    VL G ++    GQT+ALVG SGCGKST +QL+ER+YD L G V +D  +I+ L+V
Sbjct: 1046 RPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNV 1105

Query: 2135 KHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYD 2308
            + LR ++ +V QEP LF+ +I ENI YG  +  ++Q+++ +AA  ANIH F+  LP+ Y
Sbjct: 1106 QWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYS 1165

Query: 2309 TSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRT 2488
            T VG  G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GRT
Sbjct: 1166 TKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRT 1225

Query: 2489 CVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            C+VIAHRLSTIQNAD I+V +NG+  E GTHQ LLA++G+Y+ +V  Q+
Sbjct: 1226 CIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1274



 Score =  348 bits (893), Expect = 4e-94
 Identities = 212/601 (35%), Positives = 332/601 (54%), Gaps = 25/601 (4%)
 Frame = +2

Query: 911  SLFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGD------DVSI 1069
            S+F +F+Y++  +   +++  +  +I G   P   +V+G++  I +  G+      +++
Sbjct: 35   SVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITN 94

Query: 1070 KALLNSLWFIL----------LAFTG-GISTLISGSLLGKAGETMSGR----LRMDVFRN 1204
            ++ +N   F +            ++G G   L++  +        +GR    +R   F
Sbjct: 95   RSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHA 154

Query: 1205 IMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGW 1384
            IM+Q+  +FD   H+VG L +RL  D   +   I  ++      + + F G  V F  GW
Sbjct: 155  IMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGW 212

Query: 1385 NMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEY 1564
             +  +                  L     +++ +  +A  +  E ++  +TV A   Q+
Sbjct: 213  KLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKK 272

Query: 1565 MYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVF 1744
              + +    +   R  I + +  ++S   A   +  ++A+A+ +G  L+    S  Y++
Sbjct: 273  ELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVL---SGEYSIG 329

Query: 1745 QVIEALNM--ASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKG 1915
            QV+   ++   + SV  A+     +  AR +A  +F +I  K  ID+   +G  P  IKG
Sbjct: 330  QVLTVFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKG 389

Query: 1916 NINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGS 2095
            N+  R V+F+YP+R+   +L G N+    GQTVALVG SGCGKSTT+QL++R YD   G
Sbjct: 390  NLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGM 449

Query: 2096 VKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIH 2275
            V +D  DIR ++V+ LR+ I +V QEP LF  TI ENI YG EN+T D++EKA   AN +
Sbjct: 450  VSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAY 509

Query: 2276 TFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQ 2455
             F+M LP  +DT VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +VQ
Sbjct: 510  DFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQ 569

Query: 2456 EALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
             ALDKAR GRT +VIAHRLST++NAD I    +G  +E+G H  L+  +G+Y++LV  Q+
Sbjct: 570  VALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQT 629

Query: 2636 S 2638
            +
Sbjct: 630  A 630


>gi|2852441|gb|AAC02113.1| multidrug resistance p-glycoprotein [Canis
            familiaris]
          Length = 1280

 Score =  672 bits (1733), Expect = 0.0
 Identities = 375/889 (42%), Positives = 547/889 (61%), Gaps = 11/889 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            E+KILKG++ +V  G+TVALVG+SGCGKST++ L+ R Y+   GM+ +DG  I+  N+R
Sbjct: 407  EVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTDGMVCIDGQDIRTINVRH 466

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR   G+V QEP++F  T+AENIR G   +T  +IE+A K ANA++FI KL +++DT++G
Sbjct: 467  LREITGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPNKFDTLVG 526

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                +LSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA +GRTT+ I
Sbjct: 527  ERGARLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVI 586

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ------EIERAXXXX 703
            AHRLST+RNA  I  FD G+I E+G HDEL+ K+ GIY  +V  Q      E+E A
Sbjct: 587  AHRLSTVRNADVIAGFDDGVIVEKGNHDELM-KEKGIYFKLVTMQTRGNEIELENATG-- 643

Query: 704  XXXXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXX 883
                            +S +  +  E+    +  S   R+S   +
Sbjct: 644  ----------------ESKSESDALEMSPKDSGSSLIKRRSTRRSIHAPQGQDRKLGTKE 687

Query: 884  XXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV 1063
                     S + I K  S E    ++ +   +I G   PAFSI++ ++  I +   D
Sbjct: 688  DLNENVPSVSFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSIIFSRIIGIFTRDEDPE 747

Query: 1064 SIKALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDD 1237
            + +   N  S+ F++L     I+  + G   GKAGE ++ RLR  VFR++++QD S+FDD
Sbjct: 748  TKRQNSNMFSVLFLVLGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDD 807

Query: 1238 SRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXX 1417
             ++  G+LT+RLA DA  V+ AI  RLA +   I +L  G+ ++  YGW +  +
Sbjct: 808  PKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVP 867

Query: 1418 XXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKS 1597
                        L  +  +D      A ++ TE+I N++TV +LT+++     +  + +
Sbjct: 868  IIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTREQKFEYMYAQSLQV 927

Query: 1598 PHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASM 1777
            P+R ++ +     +SF++  + + +++A  + FG +L++N +     V  V  A+   +M
Sbjct: 928  PYRNSLRKAHIFGVSFSITQAMMYFSYAGCFRFGAYLVANEFMNFQDVLLVFSAIVFGAM 987

Query: 1778 SVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYPN 1954
            +V   +S+ P+Y +A++SA  +  +I +  +ID+    G  P T++GN+    V F YP
Sbjct: 988  AVGQVSSFAPDYAKAKVSAAHVIMIIEKSPLIDSYSPHGLKPNTLEGNVTFNEVVFNYPT 1047

Query: 1955 RRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSV 2134
            R    VL G ++    GQT+ALVG SGCGKST +QL+ER+YD L GSV ID  +I+ L+V
Sbjct: 1048 RPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGSVLIDGKEIKHLNV 1107

Query: 2135 KHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYD 2308
            + LR ++ +V QEP LF+ +I ENI YG  +  ++ +++ +AA  ANIH F+  LP+ Y+
Sbjct: 1108 QWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIMQAAKEANIHHFIETLPEKYN 1167

Query: 2309 TSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRT 2488
            T VG  G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GRT
Sbjct: 1168 TRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRT 1227

Query: 2489 CVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            C+VIAHRLSTIQNAD I+V +NGK  E GTHQ LLA++G+Y+ ++  Q+
Sbjct: 1228 CIVIAHRLSTIQNADLIVVFQNGKVKEHGTHQQLLAQKGIYFSMISVQA 1276



 Score =  345 bits (885), Expect = 3e-93
 Identities = 194/487 (39%), Positives = 284/487 (57%), Gaps = 1/487 (0%)
 Frame = +2

Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
            ++R   F  IM+Q+  +FD   H+VG L +RL  D   +   I  ++      I + F G
Sbjct: 147  KIRKQFFHAIMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKVGMFFQSIATFFTG 204

Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
              V F  GW +  +                  L     +++ +  +A  +  E ++  +T
Sbjct: 205  FIVGFTPGWKLTLVILAISPVLGLSAAIWAKILSSFTDKELLAYAKAGAVAEEVLAAIRT 264

Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
            V A   Q+   + +    +   R  I + +  ++S   A   +  ++A+A+ +G  L+ +
Sbjct: 265  VIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTSLVLS 324

Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
            +  T   V  V  ++ + + S+  A+     +  AR +A  +F +I  K  ID+   +G
Sbjct: 325  SEYTIGQVLTVFFSVLIGAFSIGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGH 384

Query: 1898 TP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
             P  IKGN+  + V+F+YP+R+   +L G N+    GQTVALVG SGCGKSTT+QL++R
Sbjct: 385  KPDNIKGNLEFKNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRL 444

Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
            YD   G V ID  DIR ++V+HLR+   +V QEP LF  TI ENI YG EN+T D++EKA
Sbjct: 445  YDPTDGMVCIDGQDIRTINVRHLREITGVVSQEPVLFATTIAENIRYGRENVTMDEIEKA 504

Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
               AN + F+M LP+ +DT VG  G RLSGGQKQR+AIARA+VR+PKILLLDEATSALDT
Sbjct: 505  VKEANAYDFIMKLPNKFDTLVGERGARLSGGQKQRIAIARALVRNPKILLLDEATSALDT 564

Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
            ESE +VQ ALDKAR GRT +VIAHRLST++NAD I    +G  +E+G H  L+  +G+Y+
Sbjct: 565  ESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYF 624

Query: 2615 RLVEKQS 2635
            +LV  Q+
Sbjct: 625  KLVTMQT 631


>gi|72475|pir||DVMS1A multidrug resistance protein 1a - mouse
            (fragment)
 gi|200330|gb|AAA03243.1| mdr1a protein
          Length = 1104

 Score =  671 bits (1732), Expect = 0.0
 Identities = 377/890 (42%), Positives = 547/890 (61%), Gaps = 12/890 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            E++ILKG++ +V  G+TVALVG+SGCGKST++ L+ R Y+   GM+ +DG  I+  N+R+
Sbjct: 230  EVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRY 289

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  IG+V QEP++F  T+AENIR G   +T  +IE+A K ANA++FI KL  ++DT++G
Sbjct: 290  LREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVG 349

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                 +SGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA EGRTT+ I
Sbjct: 350  ERGAHVSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVI 409

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ----EIERAXXXXXX 709
            AHRLST+RNA  I  FD G+I E+G HDEL+ ++ GIY  +V  Q    EIE
Sbjct: 410  AHRLSTVRNADVIAGFDGGVIVEQGNHDELM-REKGIYFKLVMTQTAGNEIELGNEACKS 468

Query: 710  XXXXXXXXHRSFHRDSVTS-DEERELQQSLA--RDSTRLRQSMISTTTQVPXXXXXXXXX 880
                      S  +DS +S    R  ++S+    D  R   +  +    VP
Sbjct: 469  KDEIDNLDMSS--KDSGSSLIRRRSTRKSICGPHDQDRKLSTKEALDEDVP--------- 517

Query: 881  XXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDD 1060
                     AS + I K  S E    ++ +   +I G   PAFS+++ ++  + + GG
Sbjct: 518  --------PASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPP 569

Query: 1061 VSIKALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFD 1234
             + +   N  SL F++L     I+  + G   GKAGE ++ RLR  VF+++++QD S+FD
Sbjct: 570  ETQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFD 629

Query: 1235 DSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXX 1414
            D ++  G+LT+RLA DA  V+ A   RLA +   I +L  G+ ++  YGW +  +
Sbjct: 630  DPKNTTGALTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIV 689

Query: 1415 XXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASK 1594
                         L  +  +D      + ++ TE+I N++TV +LT+++     +  + +
Sbjct: 690  PIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQ 749

Query: 1595 SPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMAS 1774
             P+R A+ +     ++F+   + + +++A  + FG +L++    T   V  V  A+   +
Sbjct: 750  IPYRNAMKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVTQQLMTFENVLLVFSAIVFGA 809

Query: 1775 MSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFAYP 1951
            M+V   +S+ P+Y +A +SA  +  +I +   ID+    G  P  ++GN+   GV F YP
Sbjct: 810  MAVGQVSSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYP 869

Query: 1952 NRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLS 2131
             R    VL G ++    GQT+ALVG SGCGKST +QL+ER+YD + GSV +D  +I+ L+
Sbjct: 870  TRPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLN 929

Query: 2132 VKHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGY 2305
            V+ LR  + +V QEP LF+ +I ENI YG  +  ++ +++ +AA  ANIH F+  LPD Y
Sbjct: 930  VQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKY 989

Query: 2306 DTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGR 2485
            +T VG  G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GR
Sbjct: 990  NTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGR 1049

Query: 2486 TCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            TC+VIAHRLSTIQNAD I+V +NGK  E GTHQ LLA++G+Y+ +V  Q+
Sbjct: 1050 TCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQA 1099



 Score =  315 bits (808), Expect = 3e-84
 Identities = 175/454 (38%), Positives = 263/454 (57%), Gaps = 1/454 (0%)
 Frame = +2

Query: 1280 DAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLK 1459
            D   +   I  ++      + + F G  + F  GW +  +                  L
Sbjct: 2    DVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILS 61

Query: 1460 FRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSL 1639
                +++ +  +A  +  E ++  +TV A   Q+   + +    +   R  I + +  ++
Sbjct: 62   SFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANI 121

Query: 1640 SFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAASYFPEYVR 1819
            S   A   +  ++A+A+ +G  L+ +   +   V  V  ++ + + SV  A+     +
Sbjct: 122  SMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFAN 181

Query: 1820 ARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSA 1996
            AR +A  +F +I  K  ID+   +G  P  I+GN+  + ++F+YP+R+   +L G N+
Sbjct: 182  ARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNLEFKNIHFSYPSRKEVQILKGLNLKV 241

Query: 1997 NFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEP 2176
              GQTVALVG SGCGKSTT+QL++R YD L G V ID  DIR ++V++LR+ I +V QEP
Sbjct: 242  KSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGVVSQEP 301

Query: 2177 TLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQ 2356
             LF  TI ENI YG E++T D++EKA   AN + F+M LP  +DT VG  G  +SGGQKQ
Sbjct: 302  VLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAHVSGGQKQ 361

Query: 2357 RVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTIQNADK 2536
            R+AIARA+VR+PKILLLDEATSALDTESE +VQ ALDKAR GRT +VIAHRLST++NAD
Sbjct: 362  RIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADV 421

Query: 2537 IIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
            I     G  +E+G H  L+  +G+Y++LV  Q++
Sbjct: 422  IAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTA 455


>gi|6755048|ref|NP_035206.1| ATP-binding cassette, sub-family B
            (MDR/TAP), member 1A; P glycoprotein 3; ATP-binding
            cassette, sub-family B (MDR/TAP), member 4; multi-drug
            resistance 3; P-glycoprotein; multiple drug resistant 1a
            [Mus musculus]
 gi|387427|gb|AAA39514.1| P-glycoprotein
          Length = 1276

 Score =  671 bits (1732), Expect = 0.0
 Identities = 377/890 (42%), Positives = 547/890 (61%), Gaps = 12/890 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            E++ILKG++ +V  G+TVALVG+SGCGKST++ L+ R Y+   GM+ +DG  I+  N+R+
Sbjct: 402  EVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRY 461

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  IG+V QEP++F  T+AENIR G   +T  +IE+A K ANA++FI KL  ++DT++G
Sbjct: 462  LREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVG 521

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                 +SGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA EGRTT+ I
Sbjct: 522  ERGAHVSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVI 581

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ----EIERAXXXXXX 709
            AHRLST+RNA  I  FD G+I E+G HDEL+ ++ GIY  +V  Q    EIE
Sbjct: 582  AHRLSTVRNADVIAGFDGGVIVEQGNHDELM-REKGIYFKLVMTQTAGNEIELGNEACKS 640

Query: 710  XXXXXXXXHRSFHRDSVTS-DEERELQQSLA--RDSTRLRQSMISTTTQVPXXXXXXXXX 880
                      S  +DS +S    R  ++S+    D  R   +  +    VP
Sbjct: 641  KDEIDNLDMSS--KDSGSSLIRRRSTRKSICGPHDQDRKLSTKEALDEDVP--------- 689

Query: 881  XXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDD 1060
                     AS + I K  S E    ++ +   +I G   PAFS+++ ++  + + GG
Sbjct: 690  --------PASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPP 741

Query: 1061 VSIKALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFD 1234
             + +   N  SL F++L     I+  + G   GKAGE ++ RLR  VF+++++QD S+FD
Sbjct: 742  ETQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFD 801

Query: 1235 DSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXX 1414
            D ++  G+LT+RLA DA  V+ A   RLA +   I +L  G+ ++  YGW +  +
Sbjct: 802  DPKNTTGALTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIV 861

Query: 1415 XXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASK 1594
                         L  +  +D      + ++ TE+I N++TV +LT+++     +  + +
Sbjct: 862  PIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQ 921

Query: 1595 SPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMAS 1774
             P+R A+ +     ++F+   + + +++A  + FG +L++    T   V  V  A+   +
Sbjct: 922  IPYRNAMKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVTQQLMTFENVLLVFSAIVFGA 981

Query: 1775 MSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFAYP 1951
            M+V   +S+ P+Y +A +SA  +  +I +   ID+    G  P  ++GN+   GV F YP
Sbjct: 982  MAVGQVSSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYP 1041

Query: 1952 NRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLS 2131
             R    VL G ++    GQT+ALVG SGCGKST +QL+ER+YD + GSV +D  +I+ L+
Sbjct: 1042 TRPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLN 1101

Query: 2132 VKHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGY 2305
            V+ LR  + +V QEP LF+ +I ENI YG  +  ++ +++ +AA  ANIH F+  LPD Y
Sbjct: 1102 VQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKY 1161

Query: 2306 DTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGR 2485
            +T VG  G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GR
Sbjct: 1162 NTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGR 1221

Query: 2486 TCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            TC+VIAHRLSTIQNAD I+V +NGK  E GTHQ LLA++G+Y+ +V  Q+
Sbjct: 1222 TCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQA 1271



 Score =  337 bits (864), Expect = 9e-91
 Identities = 188/488 (38%), Positives = 282/488 (57%), Gaps = 1/488 (0%)
 Frame = +2

Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
            ++R   F  IM Q+  +FD   H+VG L +RL  D   +   I  ++      + + F G
Sbjct: 142  KIRQKFFHAIMNQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGG 199

Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
              + F  GW +  +                  L     +++ +  +A  +  E ++  +T
Sbjct: 200  FIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELHAYAKAGAVAEEVLAAIRT 259

Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
            V A   Q+   + +    +   R  I + +  ++S   A   +  ++A+A+ +G  L+ +
Sbjct: 260  VIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVIS 319

Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
               +   V  V  ++ + + SV  A+     +  AR +A  +F +I  K  ID+   +G
Sbjct: 320  KEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFKIIDNKPSIDSFSKSGH 379

Query: 1898 TP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
             P  I+GN+  + ++F+YP+R+   +L G N+    GQTVALVG SGCGKSTT+QL++R
Sbjct: 380  KPDNIQGNLEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRL 439

Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
            YD L G V ID  DIR ++V++LR+ I +V QEP LF  TI ENI YG E++T D++EKA
Sbjct: 440  YDPLDGMVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKA 499

Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
               AN + F+M LP  +DT VG  G  +SGGQKQR+AIARA+VR+PKILLLDEATSALDT
Sbjct: 500  VKEANAYDFIMKLPHQFDTLVGERGAHVSGGQKQRIAIARALVRNPKILLLDEATSALDT 559

Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
            ESE +VQ ALDKAR GRT +VIAHRLST++NAD I     G  +E+G H  L+  +G+Y+
Sbjct: 560  ESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYF 619

Query: 2615 RLVEKQSS 2638
            +LV  Q++
Sbjct: 620  KLVMTQTA 627


>gi|266517|sp|P21447|MDR3_MOUSE Multidrug resistance protein 3
            (P-glycoprotein 3) (MDR1A)
 gi|110720|pir||A34786 multidrug resistance protein 1a - mouse
 gi|387429|gb|AAA39517.1| multidrug resistance protein
          Length = 1276

 Score =  671 bits (1732), Expect = 0.0
 Identities = 378/890 (42%), Positives = 546/890 (60%), Gaps = 12/890 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            E++ILKG++ +V  G+TVALVG+SGCGKST++ L+ R Y+   GM+ +DG  I+  N+R+
Sbjct: 402  EVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRY 461

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  IG+V QEP++F  T+AENIR G   +T  +IE+A K ANA++FI KL  ++DT++G
Sbjct: 462  LREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVG 521

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA EGRTT+ I
Sbjct: 522  ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVI 581

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ----EIERAXXXXXX 709
            AHRLST+RNA  I  FD G+I E+G HDEL+ ++ GIY  +V  Q    EIE
Sbjct: 582  AHRLSTVRNADVIAGFDGGVIVEQGNHDELM-REKGIYFKLVMTQTAGNEIELGNEACKS 640

Query: 710  XXXXXXXXHRSFHRDSVTS-DEERELQQSLA--RDSTRLRQSMISTTTQVPXXXXXXXXX 880
                      S  +DS +S    R  ++S+    D  R   +  +    VP
Sbjct: 641  KDEIDNLDMSS--KDSGSSLIRRRSTRKSICGPHDQDRKLSTKEALDEDVP--------- 689

Query: 881  XXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDD 1060
                     AS + I K  S E    ++ +   +I G   PAFS+++ ++  + + GG
Sbjct: 690  --------PASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPP 741

Query: 1061 VSIKALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFD 1234
             + +   N  SL F++L     I+  + G   GKAGE ++ RLR  VF+++++QD S+FD
Sbjct: 742  ETQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFD 801

Query: 1235 DSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXX 1414
            D ++  G+LT+RLA DA  V+ A   RLA +   I +L  G+ ++  YGW +  +
Sbjct: 802  DPKNTTGALTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIV 861

Query: 1415 XXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASK 1594
                         L  +  +D      + ++ TE+I N++TV +LT+++     +  + +
Sbjct: 862  PIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQ 921

Query: 1595 SPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMAS 1774
             P+R A+ +     ++F    + + +++A  + FG +L++    T   V  V  A+   +
Sbjct: 922  IPYRNAMKKAHVFGITFFFTQAMMYFSYAACFRFGAYLVTQQLMTFENVLLVFSAIVFGA 981

Query: 1775 MSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFAYP 1951
            M+V   +S+ P+Y +A +SA  +  +I +   ID+    G  P  ++GN+   G  F YP
Sbjct: 982  MAVGQVSSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGFVFNYP 1041

Query: 1952 NRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLS 2131
             R    VL G ++    GQT+ALVG SGCGKST +QL+ER+YD + GSV +D  +I+ L+
Sbjct: 1042 TRPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLN 1101

Query: 2132 VKHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGY 2305
            V+ LR  + +V QEP LF+ +I ENI YG  +  ++ +++ +AA  ANIH F+  LPD Y
Sbjct: 1102 VQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKY 1161

Query: 2306 DTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGR 2485
            +T VG  G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GR
Sbjct: 1162 NTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGR 1221

Query: 2486 TCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            TC+VIAHRLSTIQNAD I+V +NGK  E GTHQ LLA++G+Y+ +V  Q+
Sbjct: 1222 TCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQA 1271



 Score =  338 bits (868), Expect = 3e-91
 Identities = 189/488 (38%), Positives = 283/488 (57%), Gaps = 1/488 (0%)
 Frame = +2

Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
            ++R   F  IM Q+  +FD   H+VG L +RL  D   +   I  ++      + + F G
Sbjct: 142  KIRQKFFHAIMNQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGG 199

Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
              + F  GW +  +                  L     +++ +  +A  +  E ++  +T
Sbjct: 200  FIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELHAYAKAGAVAEEVLAAIRT 259

Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
            V A   Q+   + +    +   R  I + +  ++S   A   +  ++A+A+ +G  L+ +
Sbjct: 260  VIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVIS 319

Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
               +   V  V  ++ + + SV  A+     +  AR +A  +F +I  K  ID+   +G
Sbjct: 320  KEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFKIIDNKPSIDSFSKSGH 379

Query: 1898 TP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
             P  I+GN+  + ++F+YP+R+   +L G N+    GQTVALVG SGCGKSTT+QL++R
Sbjct: 380  KPDNIQGNLEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRL 439

Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
            YD L G V ID  DIR ++V++LR+ I +V QEP LF  TI ENI YG E++T D++EKA
Sbjct: 440  YDPLDGMVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKA 499

Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
               AN + F+M LP  +DT VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDT
Sbjct: 500  VKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 559

Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
            ESE +VQ ALDKAR GRT +VIAHRLST++NAD I     G  +E+G H  L+  +G+Y+
Sbjct: 560  ESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYF 619

Query: 2615 RLVEKQSS 2638
            +LV  Q++
Sbjct: 620  KLVMTQTA 627


>gi|126928|sp|P21449|MDR2_CRIGR Multidrug resistance protein 2
            (P-glycoprotein 2)
 gi|191167|gb|AAA68884.1| p-glycoprotein isoform II
          Length = 1276

 Score =  671 bits (1731), Expect = 0.0
 Identities = 371/885 (41%), Positives = 545/885 (60%), Gaps = 11/885 (1%)
 Frame = +2

Query: 5    LKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWL 184
            +KILKG++ +V  G+TVALVG SGCGKST++ LL R Y+   G++ +DG  I+  N+R+L
Sbjct: 406  IKILKGLNLKVQSGQTVALVGKSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIRTINVRYL 465

Query: 185  RSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIGA 364
            R  IG+V QEP++F  T+AENIR G   +T  +IE+A K ANA++FI KL  ++DT++G
Sbjct: 466  REIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGE 525

Query: 365  GAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIA 544
               QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA EGRTT+ IA
Sbjct: 526  RGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIA 585

Query: 545  HRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ------EIERAXXXXX 706
            HRLST+RNA  I  FD G+I E+G H+EL+ K+ GIY  +V  Q      E+
Sbjct: 586  HRLSTVRNADVIAGFDGGVIVEQGNHEELM-KEKGIYCRLVMMQTRGNEVELGSEADGSQ 644

Query: 707  XXXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXX 886
                        F   SV     R +  S  +D  R      +    VP
Sbjct: 645  SDTIASELTSEEFKSPSVRKSTCRSICGS--QDQERRVSVKEAQDEDVPL---------- 692

Query: 887  XXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVS 1066
                    S + I K    E   +++ ++  +I G   P FSIV+  +  + +   D  +
Sbjct: 693  -------VSFWGILKLNITEWPYLVVGVLCAVINGCMQPVFSIVFSGIIGVFTRDDDPKT 745

Query: 1067 IKALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDS 1240
             +   N  SL+F+++     ++    G   GKAGE ++ RLR  VF+++++QD S+FDD
Sbjct: 746  KQQNCNLFSLFFLVMGMICFVTYFFQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDH 805

Query: 1241 RHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXX 1420
            R++ G+LT+RLA+DA NV+ A+  RLA +   + +L  G+ ++  YGW +  +
Sbjct: 806  RNSTGALTTRLASDAANVKGAMSSRLAGITQNVANLGTGIIISLVYGWQLTLLLVVIAPL 865

Query: 1421 XXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSP 1600
                       L  +  +D      + ++ TE+I N++TV +LT+++   + +  + + P
Sbjct: 866  IILSGMMEMKVLSGQALKDKKELEVSGKIATEAIENFRTVVSLTREQKFENMYAQSLQIP 925

Query: 1601 HRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMS 1780
            +R A+ +     ++F+   + + +++A  + FG +L+++   T   V  V  A+   +++
Sbjct: 926  YRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVAHQIMTFENVMLVFSAVVFGAIA 985

Query: 1781 VMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFAYPNR 1957
               A+S+ P+Y +A++SA  +  ++ +   ID+    G  P  ++GN+    V F YP R
Sbjct: 986  AGNASSFAPDYAKAKVSASHIIRIMEKIPSIDSYSTRGLKPNWLEGNVKFNEVVFNYPTR 1045

Query: 1958 RRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVK 2137
                VL G ++    GQT+ALVG SGCGKST +QL+ER+YD + G+V +D  +I+ L+V+
Sbjct: 1046 PDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEIKQLNVQ 1105

Query: 2138 HLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYDT 2311
             LR ++ +V QEP LF+ +I ENI YG  +  ++QD++E+AA  ANIH F+  LPD Y+T
Sbjct: 1106 WLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNT 1165

Query: 2312 SVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTC 2491
             VG  G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GRTC
Sbjct: 1166 RVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTC 1225

Query: 2492 VVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVE 2626
            +VIAHRLSTIQNAD I+V +NGK  E GTHQ LLA++G+Y+ +V+
Sbjct: 1226 IVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVQ 1270



 Score =  331 bits (849), Expect = 5e-89
 Identities = 188/487 (38%), Positives = 275/487 (55%), Gaps = 1/487 (0%)
 Frame = +2

Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
            ++R   F  IM Q+  +FD   H++G L +RL  D   +   I  ++      I +
Sbjct: 145  KIRQKFFHAIMNQEIGWFDV--HDIGELNTRLTDDVSKINDGIGDKIGMFFQSIATFLAA 202

Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
              V F  GW +  +                  L     +++ +  +A  +  E ++  +T
Sbjct: 203  FIVGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRT 262

Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
            V A   Q    + +    +      I + +  ++S  +A   V  ++A+A+ +G  L+ +
Sbjct: 263  VIAFGGQNKELERYNKNLEEAKNVGIKKAVTANISIGIAYLLVYASYALAFWYGTSLVLS 322

Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
            N  +   V  V  ++   + S+   A     +  AR +A  +F +I  +  ID+    G
Sbjct: 323  NEYSVGQVLTVFFSILFGTFSIGHIAPNIEVFANARGAAYEIFKIIDNEPSIDSFSTQGH 382

Query: 1898 TP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
             P ++ GN+  + V+F+YP+R    +L G N+    GQTVALVG SGCGKSTT+QL++R
Sbjct: 383  KPDSVMGNLEFKNVHFSYPSRSGIKILKGLNLKVQSGQTVALVGKSGCGKSTTVQLLQRL 442

Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
            YD   G V ID  DIR ++V++LR+ I +V QEP LF  TI ENI YG EN+T D++EKA
Sbjct: 443  YDPTEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKA 502

Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
               AN + F+M LP  +DT VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDT
Sbjct: 503  VKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 562

Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
            ESE +VQ ALDKAR GRT +VIAHRLST++NAD I     G  +E+G H+ L+  +G+Y
Sbjct: 563  ESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIYC 622

Query: 2615 RLVEKQS 2635
            RLV  Q+
Sbjct: 623  RLVMMQT 629



 Score =  251 bits (642), Expect = 5e-65
 Identities = 130/226 (57%), Positives = 171/226 (75%), Gaps = 2/226 (0%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            ++ +L+G+S EV  G+T+ALVG SGCGKST + LL RFY+  AG + LDG  I++ N++W
Sbjct: 1047 DIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEIKQLNVQW 1106

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDV--LITDQDIEEACKMANAHEFICKLSDRYDTV 355
            LR+ +GIV QEPI+F  ++AENI  GD   +++  +IE A K AN H+FI  L D+Y+T
Sbjct: 1107 LRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTR 1166

Query: 356  IGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTL 535
            +G    QLSGGQKQR+AIARA+VR+P ILLLDEATSALDTESE++VQ ALDKA EGRT +
Sbjct: 1167 VGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCI 1226

Query: 536  CIAHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKA 673
             IAHRLSTI+NA  I+V   G + E GTH +L+++  GIY SMV+A
Sbjct: 1227 VIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQ-KGIYFSMVQA 1271


>gi|42741659|ref|NP_000918.2| ATP-binding cassette sub-family B member
            1; multidrug resistance 1; P glycoprotein 1; doxorubicin
            resistance; colchicin sensitivity [Homo sapiens]
          Length = 1280

 Score =  671 bits (1731), Expect = 0.0
 Identities = 373/889 (41%), Positives = 547/889 (60%), Gaps = 11/889 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            E+KILKG++ +V  G+TVALVG+SGCGKST++ L+ R Y+   GM+ +DG  I+  N+R+
Sbjct: 406  EVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRF 465

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  IG+V QEP++F  T+AENIR G   +T  +IE+A K ANA++FI KL  ++DT++G
Sbjct: 466  LREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVG 525

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA +GRTT+ I
Sbjct: 526  ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVI 585

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ------EIERAXXXX 703
            AHRLST+RNA  I  FD G+I E+G HDEL+ K+ GIY  +V  Q      E+E A
Sbjct: 586  AHRLSTVRNADVIAGFDDGVIVEKGNHDELM-KEKGIYFKLVTMQTAGNEVELENAAD-- 642

Query: 704  XXXXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXX 883
                            +S +  +  E+  + +R S   ++S   +
Sbjct: 643  ----------------ESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKE 686

Query: 884  XXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV 1063
                     S + I K    E    ++ +   +I G   PAF+I++ ++  + +   D
Sbjct: 687  ALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPE 746

Query: 1064 SIKALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDD 1237
            + +   N  SL F+ L     I+  + G   GKAGE ++ RLR  VFR++++QD S+FDD
Sbjct: 747  TKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDD 806

Query: 1238 SRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXX 1417
             ++  G+LT+RLA DA  V+ AI  RLA +   I +L  G+ ++F YGW +  +
Sbjct: 807  PKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVP 866

Query: 1418 XXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKS 1597
                        L  +  +D      + ++ TE+I N++TV +LT+++     +  + +
Sbjct: 867  IIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQV 926

Query: 1598 PHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASM 1777
            P+R ++ +     ++F+   + + +++A  + FG +L+++   +   V  V  A+   +M
Sbjct: 927  PYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAM 986

Query: 1778 SVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYPN 1954
            +V   +S+ P+Y +A+ISA  +  +I +  +ID+    G  P T++GN+    V F YP
Sbjct: 987  AVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPT 1046

Query: 1955 RRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSV 2134
            R    VL G ++    GQT+ALVG SGCGKST +QL+ER+YD L G V +D  +I+ L+V
Sbjct: 1047 RPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNV 1106

Query: 2135 KHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYD 2308
            + LR ++ +V QEP LF+ +I ENI YG  +  ++Q+++ +AA  ANIH F+  LP+ Y
Sbjct: 1107 QWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYS 1166

Query: 2309 TSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRT 2488
            T VG  G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GRT
Sbjct: 1167 TKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRT 1226

Query: 2489 CVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            C+VIAHRLSTIQNAD I+V +NG+  E GTHQ LLA++G+Y+ +V  Q+
Sbjct: 1227 CIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1275



 Score =  348 bits (893), Expect = 4e-94
 Identities = 210/599 (35%), Positives = 330/599 (55%), Gaps = 23/599 (3%)
 Frame = +2

Query: 911  SLFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGD------DVSI 1069
            S+F +F+Y++  +   +++  +  +I G   P   +V+G++  I +  G+      +++
Sbjct: 35   SVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITN 94

Query: 1070 KALLNSLWFIL----------LAFTG-GISTLISGSLLGKAGETMSGR----LRMDVFRN 1204
            ++ +N   F +            ++G G   L++  +        +GR    +R   F
Sbjct: 95   RSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHA 154

Query: 1205 IMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGW 1384
            IM+Q+  +FD   H+VG L +RL  D   +   I  ++      + + F G  V F  GW
Sbjct: 155  IMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGW 212

Query: 1385 NMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEY 1564
             +  +                  L     +++ +  +A  +  E ++  +TV A   Q+
Sbjct: 213  KLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKK 272

Query: 1565 MYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVF 1744
              + +    +   R  I + +  ++S   A   +  ++A+A+ +G  L+ +   +   V
Sbjct: 273  ELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVL 332

Query: 1745 QVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNI 1921
             V  ++ + + SV  A+     +  AR +A  +F +I  K  ID+   +G  P  IKGN+
Sbjct: 333  TVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNL 392

Query: 1922 NMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVK 2101
              R V+F+YP+R+   +L G N+    GQTVALVG SGCGKSTT+QL++R YD   G V
Sbjct: 393  EFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVS 452

Query: 2102 IDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTF 2281
            +D  DIR ++V+ LR+ I +V QEP LF  TI ENI YG EN+T D++EKA   AN + F
Sbjct: 453  VDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDF 512

Query: 2282 VMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEA 2461
            +M LP  +DT VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +VQ A
Sbjct: 513  IMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVA 572

Query: 2462 LDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
            LDKAR GRT +VIAHRLST++NAD I    +G  +E+G H  L+  +G+Y++LV  Q++
Sbjct: 573  LDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTA 631


>gi|45382457|ref|NP_990225.1| ABC transporter protein [Gallus gallus]
 gi|3355757|emb|CAA08835.1| ABC transporter protein; P-glycoprotein
            [Gallus gallus]
          Length = 1288

 Score =  671 bits (1730), Expect = 0.0
 Identities = 374/882 (42%), Positives = 530/882 (59%), Gaps = 4/882 (0%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            +++ILKG++ +VN G+TVALVG SGCGKST++ L+ RFY+   G I +DG  ++  N+R+
Sbjct: 414  DVEILKGLNLKVNCGQTVALVGGSGCGKSTTVQLIQRFYDPKEGTITIDGQDLKSLNVRY 473

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  IG+V QEP++F  T+AENIR G   +T ++IE A K ANA++FI KL  +++TV+G
Sbjct: 474  LREIIGVVNQEPVLFATTIAENIRYGREDVTMEEIERATKEANAYDFIMKLPKKFETVVG 533

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                Q+SGGQKQR+AIARA+V  P+ILLLDEATSALDTESE +VQ ALDKA EGRTT+ +
Sbjct: 534  ERGAQMSGGQKQRIAIARALVHNPKILLLDEATSALDTESESVVQAALDKAREGRTTVVV 593

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
            AHRLST+RNA  I VF+ G+I E+G H +LI K  GIY  +V  Q IE
Sbjct: 594  AHRLSTVRNADLIAVFESGVITEQGNHSQLIEKK-GIYYKLVNMQTIETEDPSSEKSENA 652

Query: 722  XXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXXXXGA 901
                  S  R    S+ +  L++ L R STR
Sbjct: 653  V-----SVKRSGSQSNLDESLKKELRRGSTRRSMKKPGEPNDTDEKGSSPDEELP----- 702

Query: 902  MEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV-SIKAL 1078
               S   + K    E    +      ++ G   PAFS+++ ++  I S     V   K+
Sbjct: 703  -PVSFLKLMKLNKNEWPYFVAGTFCAIVNGALQPAFSVIFSEIIGIFSETDQKVLREKSN 761

Query: 1079 LNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGS 1258
            L SL F+ L      +  + G   GKAGE ++ +LR   F+ +++QD ++FDD +++ G+
Sbjct: 762  LYSLLFLALGIISFFTFFVQGFAFGKAGEILTMKLRFMAFKAMLRQDMAWFDDPKNSTGA 821

Query: 1259 LTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXX 1438
            LT+RLA DA  V+ A   RLA +   I +L  G+ ++  YGW +  +
Sbjct: 822  LTTRLANDASQVKGATGVRLALIAQNIANLGTGIIISLVYGWQLTLLLLAVVPIIAVAGM 881

Query: 1439 XXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIV 1618
                 L    ++D      A ++ TE+I N +TV +LT+++     +      P+R ++
Sbjct: 882  IEMKMLAGHAKKDKIELEAAGKIATEAIENIRTVASLTREKRFELMYGEHLLVPYRNSVK 941

Query: 1619 RGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAAS 1798
            +       F+L+ + + + +A  + FG +L+ N      TVF V  A+   +M++   +S
Sbjct: 942  KAHIFGFCFSLSQAMMFFTYAGCFRFGAYLVVNGHIEYKTVFLVFSAVVFGAMALGQTSS 1001

Query: 1799 YFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFAYPNRRRQLVL 1975
            + P+Y +A+ISA  +F +  +   ID+    G+ P    GN  ++ V F YPNR    +L
Sbjct: 1002 FAPDYAKAKISAAHLFVLFNRVPPIDSYREDGEKPEKFGGNTRIKDVKFNYPNRPEVKIL 1061

Query: 1976 DGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNI 2155
             G N++   G+T+ALVG SGCGKST +QL+ER+YD L G +  DD D + L+++ LR +I
Sbjct: 1062 QGLNLAVEKGETLALVGSSGCGKSTVVQLLERFYDPLSGEIVFDDIDAKTLNIQWLRSHI 1121

Query: 2156 ALVGQEPTLFNLTIRENITYG--LENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASG 2329
             +V QEP LF+ TI ENI YG     ++ +++  AA  A+IH+F+  LP+ Y+T VG  G
Sbjct: 1122 GIVSQEPILFDFTIAENIAYGDNSREVSHEEIISAAKAASIHSFIDSLPEKYNTRVGDKG 1181

Query: 2330 GRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHR 2509
             +LSGGQKQR+AIARA++R P+ILLLDEATSALDTESEKIVQEALDKAR GRTC+VIAHR
Sbjct: 1182 TQLSGGQKQRIAIARALIRKPQILLLDEATSALDTESEKIVQEALDKAREGRTCIVIAHR 1241

Query: 2510 LSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            LSTIQNADKI V +NGK IE+GTHQ LLA +G YY LV  QS
Sbjct: 1242 LSTIQNADKIAVIQNGKVIEQGTHQQLLAEKGFYYSLVNVQS 1283



 Score =  330 bits (846), Expect = 1e-88
 Identities = 187/487 (38%), Positives = 279/487 (56%), Gaps = 1/487 (0%)
 Frame = +2

Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
            ++R   F  IM+Q+  +FD +  + G L +RL  D   +   I  ++  ++    +   G
Sbjct: 154  KIREKFFHAIMRQEIGWFDVN--DAGELNTRLIDDVSKINEGIGDKIGFLIQSETTFLTG 211

Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
              V F  GW +  +                  L     ++  +  +A  +  E +S  +T
Sbjct: 212  FIVGFIRGWKLTLVILAVSPVLGLSAALWAKILTAFTDKEQAAYAKAGAVAEEVLSAVRT 271

Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
            V A   QE     +    +   R  I + +  ++S   A   +  ++A+A+ +G  LI
Sbjct: 272  VIAFGGQEKEIKRYHKNLEDAKRIGIRKAITSNISMGAAFLLIYASYALAFWYGTTLILA 331

Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
            N  +   V  V  ++ + + S+   A     +  AR +A  +F +I  +  ID+    G
Sbjct: 332  NEYSIGNVLTVFFSVLIGAFSIGQTAPSIEAFANARGAAYAIFNIIDNEPEIDSYSDAGH 391

Query: 1898 TPT-IKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
             P  IKGN+  + V+F YP+R    +L G N+  N GQTVALVG SGCGKSTT+QLI+R+
Sbjct: 392  KPDHIKGNLEFQNVFFNYPSRPDVEILKGLNLKVNCGQTVALVGGSGCGKSTTVQLIQRF 451

Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
            YD   G++ ID  D++ L+V++LR+ I +V QEP LF  TI ENI YG E++T +++E+A
Sbjct: 452  YDPKEGTITIDGQDLKSLNVRYLREIIGVVNQEPVLFATTIAENIRYGREDVTMEEIERA 511

Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
               AN + F+M LP  ++T VG  G ++SGGQKQR+AIARA+V +PKILLLDEATSALDT
Sbjct: 512  TKEANAYDFIMKLPKKFETVVGERGAQMSGGQKQRIAIARALVHNPKILLLDEATSALDT 571

Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
            ESE +VQ ALDKAR GRT VV+AHRLST++NAD I V  +G   E+G H  L+ ++G+YY
Sbjct: 572  ESESVVQAALDKAREGRTTVVVAHRLSTVRNADLIAVFESGVITEQGNHSQLIEKKGIYY 631

Query: 2615 RLVEKQS 2635
            +LV  Q+
Sbjct: 632  KLVNMQT 638


>gi|31442763|gb|AAN07780.2| multidrug resistance p-glycoprotein
            [Macaca fascicularis]
          Length = 1283

 Score =  671 bits (1730), Expect = 0.0
 Identities = 376/890 (42%), Positives = 551/890 (61%), Gaps = 12/890 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            E+KILKG++ +V  G+TVALVG+SGCGKST++ L+ R Y+   GM+ +DG  I+  N+R+
Sbjct: 409  EVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRF 468

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  IG+V QEP++F  T+AENIR G   +T  +IE+A K ANA++FI KL  ++DT++G
Sbjct: 469  LREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPQKFDTLVG 528

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA +GRTT+ I
Sbjct: 529  ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVI 588

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ------EIERAXXXX 703
            AHRLST+RNA  I  FD G+I E+G HDEL+ K+ GIY  +V  Q      E+E A
Sbjct: 589  AHRLSTVRNADVIAGFDDGVIVEKGNHDELM-KEKGIYFKLVTMQTAGNEIELENAADES 647

Query: 704  XXXXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXX 883
                        S H    +   +R  ++S+     + R+  +ST   +
Sbjct: 648  KSEIDTL---EMSSHDSGSSLIRKRSTRRSVRGSQGQDRK--LSTKEALDESIP------ 696

Query: 884  XXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV 1063
                     S + I K    E    ++ +   +I G   PAF++++ ++  I +   DD
Sbjct: 697  -------PVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAVIFSKIIGIFTRN-DDA 748

Query: 1064 SIK---ALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFD 1234
              K   + L SL F++L     I+  + G   GKAGE ++ RLR  VFR++++QD S+FD
Sbjct: 749  ETKRQNSNLFSLLFLVLGIVSFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFD 808

Query: 1235 DSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXX 1414
            D ++  G+LT+RLA DA  V+ AI  RLA +   I +L  G+ ++  YGW +  +
Sbjct: 809  DPKNTTGALTTRLANDAAQVKGAIGSRLAIITQNIANLGTGIIISLIYGWQLTLLLLAIV 868

Query: 1415 XXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASK 1594
                         L  +  +D      A ++ TE+I N++TV +LT+++     +  + +
Sbjct: 869  PIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYDQSLQ 928

Query: 1595 SPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMAS 1774
             P+R ++ +     ++F+   + + +++A  + FG +L++++  +   V  V  A+   +
Sbjct: 929  VPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHSLMSFEDVLLVFSAVVFGA 988

Query: 1775 MSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYP 1951
            M+V   +S+ P+Y +A++SA  +  +I +  +ID+    G  P T++GN+    V F YP
Sbjct: 989  MAVGQVSSFAPDYAKAKVSAAHIIMIIEKTPLIDSYSTEGLKPNTLEGNVTFNEVVFNYP 1048

Query: 1952 NRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLS 2131
             R    VL G ++    GQT+ALVG SGCGKST +QL+ER+YD L G V +D  +I+ L+
Sbjct: 1049 TRLDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKQLN 1108

Query: 2132 VKHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGY 2305
            V+ LR ++ +V QEP LF+ +I ENI YG  +  ++Q+++ +AA  ANIH F+  LP+ Y
Sbjct: 1109 VQWLRAHLGIVSQEPILFDCSISENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKY 1168

Query: 2306 DTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGR 2485
             T VG  G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GR
Sbjct: 1169 STRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGR 1228

Query: 2486 TCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            TC+VIAHRLSTIQNAD I+V +NG+  E GTHQ LLA++G+Y+ +V  Q+
Sbjct: 1229 TCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1278



 Score =  343 bits (879), Expect = 2e-92
 Identities = 209/602 (34%), Positives = 323/602 (52%), Gaps = 26/602 (4%)
 Frame = +2

Query: 911  SLFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGG----------- 1054
            S+F +F+Y++  +   +++  +  +I G   P   +V+G +    +  G
Sbjct: 35   SVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGDMTDTFANAGNLGDLGALLFN 94

Query: 1055 --------DDVSIKALLNSLWFILLAFTG-GISTLISGSLLGKAGETMSGR----LRMDV 1195
                    D V +  L   +      ++G G   L++  +        +GR    +R
Sbjct: 95   NTNSSNITDTVPVMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQF 154

Query: 1196 FRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFY 1375
            F  IM+Q+  +FD   H+VG L +RL  D   +   I  ++      + + F G  V F
Sbjct: 155  FHAIMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFT 212

Query: 1376 YGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTK 1555
             GW +  +                  L     +++ +  +A  +  E ++  +TV A
Sbjct: 213  RGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGG 272

Query: 1556 QEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPY 1735
            Q+   + +    +   R  I + +  ++S   A   +  ++A+A+ +G  L+ +   +
Sbjct: 273  QKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSKEYSIG 332

Query: 1736 TVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIK 1912
             V  V  ++ + + SV  A+     +  AR +A  +F +I  K  ID+   +G  P  IK
Sbjct: 333  QVLTVFFSVLIGAFSVGQASPSIEAFANARGAAFEIFKIIDNKPSIDSYSKSGHKPDNIK 392

Query: 1913 GNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCG 2092
            GN+  R V+F+YP+R+   +L G N+    GQTVALVG SGCGKSTT+QL++R YD   G
Sbjct: 393  GNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEG 452

Query: 2093 SVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANI 2272
             V +D  DIR ++V+ LR+ I +V QEP LF  TI ENI YG E++T D++EKA   AN
Sbjct: 453  MVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANA 512

Query: 2273 HTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIV 2452
            + F+M LP  +DT VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +V
Sbjct: 513  YDFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVV 572

Query: 2453 QEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
            Q ALDKAR GRT +VIAHRLST++NAD I    +G  +E+G H  L+  +G+Y++LV  Q
Sbjct: 573  QVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQ 632

Query: 2633 SS 2638
            ++
Sbjct: 633  TA 634


>gi|46394984|gb|AAS91648.1| multidrug resistance protein;
            P-glycoprotein [Macaca mulatta]
          Length = 1283

 Score =  671 bits (1730), Expect = 0.0
 Identities = 376/890 (42%), Positives = 551/890 (61%), Gaps = 12/890 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            E+KILKG++ +V  G+TVALVG+SGCGKST++ L+ R Y+   GM+ +DG  I+  N+R+
Sbjct: 409  EVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRF 468

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  IG+V QEP++F  T+AENIR G   +T  +IE+A K ANA++FI KL  ++DT++G
Sbjct: 469  LREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPQKFDTLVG 528

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA +GRTT+ I
Sbjct: 529  ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVI 588

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ------EIERAXXXX 703
            AHRLST+RNA  I  FD G+I E+G HDEL+ K+ GIY  +V  Q      E+E A
Sbjct: 589  AHRLSTVRNADVIAGFDDGVIVEKGNHDELM-KEKGIYFKLVTMQTAGNEIELENAADES 647

Query: 704  XXXXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXX 883
                        S H    +   +R  ++S+     + R+  +ST   +
Sbjct: 648  KSEIDTL---EMSSHDSGSSLIRKRSTRRSVRGSQGQDRK--LSTKEALDESIP------ 696

Query: 884  XXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV 1063
                     S + I K    E    ++ +   +I G   PAF++++ ++  I +   DD
Sbjct: 697  -------PVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAVIFSKIIGIFTRN-DDA 748

Query: 1064 SIK---ALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFD 1234
              K   + L SL F++L     I+  + G   GKAGE ++ RLR  VFR++++QD S+FD
Sbjct: 749  ETKQQNSNLFSLLFLVLGIVSFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFD 808

Query: 1235 DSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXX 1414
            D ++  G+LT+RLA DA  V+ AI  RLA +   I +L  G+ ++  YGW +  +
Sbjct: 809  DPKNTTGALTTRLANDAAQVKGAIGSRLAIITQNIANLGTGIIISLIYGWQLTLLLLAIV 868

Query: 1415 XXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASK 1594
                         L  +  +D      A ++ TE+I N++TV +LT+++     +  + +
Sbjct: 869  PIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYDQSLQ 928

Query: 1595 SPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMAS 1774
             P+R ++ +     ++F+   + + +++A  + FG +L++++  +   V  V  A+   +
Sbjct: 929  VPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHSLMSFEDVLLVFSAVVFGA 988

Query: 1775 MSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYP 1951
            M+V   +S+ P+Y +A++SA  +  +I +  +ID+    G  P T++GN+    V F YP
Sbjct: 989  MAVGQVSSFAPDYAKAKVSAAHIIMIIEKTPLIDSYSTEGLKPNTLEGNVTFNEVVFNYP 1048

Query: 1952 NRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLS 2131
             R    VL G ++    GQT+ALVG SGCGKST +QL+ER+YD L G V +D  +I+ L+
Sbjct: 1049 TRLDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKQLN 1108

Query: 2132 VKHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGY 2305
            V+ LR ++ +V QEP LF+ +I ENI YG  +  ++Q+++ +AA  ANIH F+  LP+ Y
Sbjct: 1109 VQWLRAHLGIVSQEPILFDCSISENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKY 1168

Query: 2306 DTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGR 2485
             T VG  G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GR
Sbjct: 1169 STRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGR 1228

Query: 2486 TCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            TC+VIAHRLSTIQNAD I+V +NG+  E GTHQ LLA++G+Y+ +V  Q+
Sbjct: 1229 TCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1278



 Score =  341 bits (874), Expect = 6e-92
 Identities = 208/602 (34%), Positives = 323/602 (53%), Gaps = 26/602 (4%)
 Frame = +2

Query: 911  SLFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGG----------- 1054
            S+F +F+Y++  +   +++  +  +I G   P   +V+G +    +  G
Sbjct: 35   SVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGDMTDTFANAGNLGDLGALLFN 94

Query: 1055 --------DDVSIKALLNSLWFILLAFTG-GISTLISGSLLGKAGETMSGR----LRMDV 1195
                    D V +  L   +      ++G G   L++  +        +GR    +R
Sbjct: 95   NTNSSNITDTVPVMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQF 154

Query: 1196 FRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFY 1375
            F  IM+Q+  +FD   H+VG L +RL  +   +   I  ++      + + F G  V F
Sbjct: 155  FHAIMRQEIGWFDV--HDVGELNTRLTDEVSKINEGIGDKIGMFFQSMATFFTGFIVGFT 212

Query: 1376 YGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTK 1555
             GW +  +                  L     +++ +  +A  +  E ++  +TV A
Sbjct: 213  RGWKLTLVILAISPILGLSAAAWAKILSSFTDKELLAYAKAGVVAEEVLAAIRTVIAFGG 272

Query: 1556 QEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPY 1735
            Q+   + +    +   R  I + +  ++S   A   +  ++A+A+ +G  L+ +   +
Sbjct: 273  QKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSKEYSIG 332

Query: 1736 TVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIK 1912
             V  V  ++ + + SV  A+     +  AR +A  +F +I  K  ID+   +G  P  IK
Sbjct: 333  QVLTVFFSVLIGAFSVGQASPSIEAFANARGAAFEIFKIIDNKPSIDSYSKSGHKPDNIK 392

Query: 1913 GNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCG 2092
            GN+  R V+F+YP+R+   +L G N+    GQTVALVG SGCGKSTT+QL++R YD   G
Sbjct: 393  GNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEG 452

Query: 2093 SVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANI 2272
             V +D  DIR ++V+ LR+ I +V QEP LF  TI ENI YG E++T D++EKA   AN
Sbjct: 453  MVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANA 512

Query: 2273 HTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIV 2452
            + F+M LP  +DT VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +V
Sbjct: 513  YDFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVV 572

Query: 2453 QEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
            Q ALDKAR GRT +VIAHRLST++NAD I    +G  +E+G H  L+  +G+Y++LV  Q
Sbjct: 573  QVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQ 632

Query: 2633 SS 2638
            ++
Sbjct: 633  TA 634


>gi|22775296|gb|AAN07779.1| multidrug resistance p-glycoprotein
            [Macaca mulatta]
          Length = 1283

 Score =  671 bits (1730), Expect = 0.0
 Identities = 376/890 (42%), Positives = 551/890 (61%), Gaps = 12/890 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            E+KILKG++ +V  G+TVALVG+SGCGKST++ L+ R Y+   GM+ +DG  I+  N+R+
Sbjct: 409  EVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRF 468

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  IG+V QEP++F  T+AENIR G   +T  +IE+A K ANA++FI KL  ++DT++G
Sbjct: 469  LREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPQKFDTLVG 528

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA +GRTT+ I
Sbjct: 529  ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVI 588

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ------EIERAXXXX 703
            AHRLST+RNA  I  FD G+I E+G HDEL+ K+ GIY  +V  Q      E+E A
Sbjct: 589  AHRLSTVRNADVIAGFDDGVIVEKGNHDELM-KEKGIYFKLVTMQTAGNEIELENAADES 647

Query: 704  XXXXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXX 883
                        S H    +   +R  ++S+     + R+  +ST   +
Sbjct: 648  KSEIDTL---EMSSHDSGSSLIRKRSTRRSVRGSQGQDRK--LSTKEALDESIP------ 696

Query: 884  XXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV 1063
                     S + I K    E    ++ +   +I G   PAF++++ ++  I +   DD
Sbjct: 697  -------PVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAVIFSKIIGIFTRN-DDA 748

Query: 1064 SIK---ALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFD 1234
              K   + L SL F++L     I+  + G   GKAGE ++ RLR  VFR++++QD S+FD
Sbjct: 749  ETKRQNSNLFSLLFLVLGIVSFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFD 808

Query: 1235 DSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXX 1414
            D ++  G+LT+RLA DA  V+ AI  RLA +   I +L  G+ ++  YGW +  +
Sbjct: 809  DPKNTTGALTTRLANDAAQVKGAIGSRLAIITQNIANLGTGIIISLIYGWQLTLLLLAIV 868

Query: 1415 XXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASK 1594
                         L  +  +D      A ++ TE+I N++TV +LT+++     +  + +
Sbjct: 869  PIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYDQSLQ 928

Query: 1595 SPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMAS 1774
             P+R ++ +     ++F+   + + +++A  + FG +L++++  +   V  V  A+   +
Sbjct: 929  VPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHSLMSFEDVLLVFSAVVFGA 988

Query: 1775 MSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYP 1951
            M+V   +S+ P+Y +A++SA  +  +I +  +ID+    G  P T++GN+    V F YP
Sbjct: 989  MAVGQVSSFAPDYAKAKVSAAHIIMIIEKTPLIDSYSTEGLKPNTLEGNVTFNEVVFNYP 1048

Query: 1952 NRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLS 2131
             R    VL G ++    GQT+ALVG SGCGKST +QL+ER+YD L G V +D  +I+ L+
Sbjct: 1049 TRLDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKQLN 1108

Query: 2132 VKHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGY 2305
            V+ LR ++ +V QEP LF+ +I ENI YG  +  ++Q+++ +AA  ANIH F+  LP+ Y
Sbjct: 1109 VQWLRAHLGIVSQEPILFDCSISENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKY 1168

Query: 2306 DTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGR 2485
             T VG  G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GR
Sbjct: 1169 STRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGR 1228

Query: 2486 TCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            TC+VIAHRLSTIQNAD I+V +NG+  E GTHQ LLA++G+Y+ +V  Q+
Sbjct: 1229 TCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1278



 Score =  344 bits (883), Expect = 5e-93
 Identities = 209/602 (34%), Positives = 324/602 (53%), Gaps = 26/602 (4%)
 Frame = +2

Query: 911  SLFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGG----------- 1054
            S+F +F+Y++  +   +++ ++  +I G   P   +V+G +    +  G
Sbjct: 35   SVFSMFRYSNWLDKLYMVVGILAAIIHGAGLPLMMLVFGDMTDTFANAGNLGDLGALLFN 94

Query: 1055 --------DDVSIKALLNSLWFILLAFTG-GISTLISGSLLGKAGETMSGR----LRMDV 1195
                    D V +  L   +      ++G G   L++  +        +GR    +R
Sbjct: 95   NTNSSNITDTVPVMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQF 154

Query: 1196 FRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFY 1375
            F  IM+Q+  +FD   H+VG L +RL  D   +   I  ++      + + F G  V F
Sbjct: 155  FHAIMRQEIGWFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFT 212

Query: 1376 YGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTK 1555
             GW +  +                  L     +++ +  +A  +  E ++  +TV A
Sbjct: 213  RGWKLTLVILAISPVLGVSAAAWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGG 272

Query: 1556 QEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPY 1735
            Q+   + +    +   R  I + +  ++S   A   +  ++A+A+ +G  L+ +   +
Sbjct: 273  QKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSKEYSIG 332

Query: 1736 TVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIK 1912
             V  V  ++ + + SV  A+     +  AR +A  +F +I  K  ID+   +G  P  IK
Sbjct: 333  QVLTVFFSVLIGAFSVGQASPSIEAFANARGAAFEIFKIIDNKPSIDSYSKSGHKPDNIK 392

Query: 1913 GNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCG 2092
            GN+  R V+F+YP+R+   +L G N+    GQTVALVG SGCGKSTT+QL++R YD   G
Sbjct: 393  GNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEG 452

Query: 2093 SVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANI 2272
             V +D  DIR ++V+ LR+ I +V QEP LF  TI ENI YG E++T D++EKA   AN
Sbjct: 453  MVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANA 512

Query: 2273 HTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIV 2452
            + F+M LP  +DT VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +V
Sbjct: 513  YDFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVV 572

Query: 2453 QEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
            Q ALDKAR GRT +VIAHRLST++NAD I    +G  +E+G H  L+  +G+Y++LV  Q
Sbjct: 573  QVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQ 632

Query: 2633 SS 2638
            ++
Sbjct: 633  TA 634


>gi|25297453|pir||D87789 protein C34G6.4 [imported] - Caenorhabditis
            elegans
          Length = 1289

 Score =  670 bits (1729), Expect = 0.0
 Identities = 368/886 (41%), Positives = 529/886 (59%), Gaps = 9/886 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            ++ +LKG+S E+  G+ +ALVG SGCGKST + LL RFY+   G + +DG+ ++E N+
Sbjct: 406  DIHVLKGISLELKAGDKIALVGSSGCGKSTIVNLLQRFYDPTKGRVLIDGVDLREVNVHS 465

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  IGIV QEP++F  T+ ENI+MG+   T   + EACKMANA++FI +L D Y T +G
Sbjct: 466  LREQIGIVSQEPVLFDGTIYENIKMGNEHATHDQVVEACKMANANDFIKRLPDGYGTRVG 525

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
               VQLSGGQKQR+AIARA+V+ P+ILLLDEATSALDTE+ER VQ ALD+A  GRTT+ +
Sbjct: 526  EKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQGALDQAQAGRTTIIV 585

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEI--ERAXXXXXXXX 715
            AHRLSTIRN  +I VF  G I E G+H+EL+SK  GI+  M +AQ +  ++
Sbjct: 586  AHRLSTIRNVDRIFVFKAGNIVESGSHEELMSKQ-GIFYDMTQAQVVRQQQQEAGKDIED 644

Query: 716  XXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSM-----ISTTTQVPXXXXXXXXX 880
                  H    R S T         S+A    +L + +      +  T
Sbjct: 645  TISESAHSHLSRKSSTRSAI-----SIATSIHQLAEEVELIDPFNGQTNQDVIRSRILSA 699

Query: 881  XXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDD 1060
                  A   S+F IFK+   ++   I  +    I G   P F++VY ++F + S   D
Sbjct: 700  FGGECKAPPTSMFKIFKFNGDKVGWFIGGIFGAFIFGSVTPVFALVYAEIFNVYSLPADQ 759

Query: 1061 VSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDS 1240
            +          F+L+  T  +    S + LG+ GE+++ +LR + F+N+++QD +++DD
Sbjct: 760  MQANVYFWCGMFVLMGITFFVGFFTSANCLGRCGESLTMKLRFEAFKNLLRQDIAFYDDL 819

Query: 1241 RHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXX 1420
            RH  G L +R ATDAPNV+     RL  VL  IV++   +G+ FYYGW +A I
Sbjct: 820  RHGTGKLCTRFATDAPNVRYVFT-RLPVVLASIVTICGALGIGFYYGWQLALI-LVVMVP 877

Query: 1421 XXXXXXXXXXYLKFRGQ-RDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKS 1597
                       ++F  Q RD     EA ++ ++++ + +TV +L +QE  +  +    +
Sbjct: 878  LLVMGGYFEMQMRFGKQIRDTQLLEEAGKVASQAVEHIRTVHSLNRQEQFHFTYCEYLRE 937

Query: 1598 PHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASM 1777
            P    +         FA + S + + +A A+  G   ++     P  V++V  A++
Sbjct: 938  PFNTNLKHAHTYGAVFAFSQSLIFFMYAAAFYLGSIFVNQQAMQPIDVYRVFFAISFCGQ 997

Query: 1778 SVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNR 1957
             +    S+ P+ V+AR++A ++F +I   + ID+   +G    I GNI++R V+F YP R
Sbjct: 998  MIGNTTSFIPDVVKARLAASLLFYLIEHPTPIDSLSDSGIVKPITGNISIRNVFFNYPTR 1057

Query: 1958 RRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVK 2137
            +   VL GF +    G+TVALVG SGCGKST + L+ER+Y+   G + ID  +IR+L++
Sbjct: 1058 KDTKVLQGFTLDIKAGKTVALVGHSGCGKSTIMGLLERFYNQDKGMIMIDGDNIRNLNIS 1117

Query: 2138 HLRDNIALVGQEPTLFNLTIRENITYGLE-NITQDQVEKAATLANIHTFVMGLPDGYDTS 2314
             LR+ + +V QEPTLF+ TI ENI YG   N+T  ++ +AA +ANIH F++GLPDGYDT
Sbjct: 1118 SLREQVCIVSQEPTLFDCTIGENICYGTNRNVTYQEIVEAAKMANIHNFILGLPDGYDTH 1177

Query: 2315 VGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCV 2494
            VG  G +LSGGQKQR+AIARA+VR P +LLLDEATSALDTESEKIVQEALD A+ GRTC+
Sbjct: 1178 VGEKGTQLSGGQKQRIAIARALVRSPSVLLLDEATSALDTESEKIVQEALDAAKQGRTCL 1237

Query: 2495 VIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
            VIAHRLSTIQN+D I +   GK +E+GTH  L+ +  +Y +  E Q
Sbjct: 1238 VIAHRLSTIQNSDVIAIVSEGKIVEKGTHDELIRKSEIYQKFCETQ 1283



 Score =  323 bits (829), Expect = 1e-86
 Identities = 198/596 (33%), Positives = 324/596 (54%), Gaps = 24/596 (4%)
 Frame = +2

Query: 917  FDIFKYASP-EMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILS--------AGGDDVSI 1069
            + IF Y    ++  +I   V  +I G  +P  +IV G +  +           G D+V+
Sbjct: 36   YGIFYYTQGVDLLLLITGTVAAVIHGAGFPLLAIVLGGMTTVFLRAQNSDFVVGVDNVNP 95

Query: 1070 KALL-------NS------LWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIM 1210
            + L+       NS      +++++L      ++ +  +      E +  +LR +  + I+
Sbjct: 96   EGLVPISLDEFNSEVVKYCIYYLVLGVLMFFTSYVQIACFESYAERLVHKLRQNYLKAIL 155

Query: 1211 QQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNM 1390
            +Q   +FD  +   G+LT+RL  D   V+  +  + A ++    +   G GV F+Y W+M
Sbjct: 156  RQQIQWFD--KQQTGNLTARLTDDLERVREGLGDKFALLVQMFAAFLAGYGVGFFYSWSM 213

Query: 1391 APIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMY 1570
              +                  +  R + + ++   A  +  E+ S+ +TV +L   +
Sbjct: 214  TLVMMGFAPLIVLSGAKMSKSMATRTRVEQETYAVAGAIAEETFSSIRTVHSLNGHKREL 273

Query: 1571 DAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPY-TVFQ 1747
            D F  A +   +  IV+  +  +    +   +  ++A+A+ +G  LI N+ +     +F
Sbjct: 274  DRFYNALEVGRQTGIVKYCYMGIGVGFSNLCMYSSYALAFWYGSTLIINDPTFDRGLIFT 333

Query: 1748 VIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD-TPTIKGNIN 1924
            V  A+   S S+  A  +   +  AR +A  +  +I     ID   L G     +KG+I+
Sbjct: 334  VFFAVLSGSTSLGGALPHLASFGTARGAASTVLRVINSHPKIDPYSLEGILVDNMKGDIS 393

Query: 1925 MRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKI 2104
             + V+F YP+R+   VL G ++    G  +ALVG SGCGKST + L++R+YD   G V I
Sbjct: 394  FKDVHFRYPSRKDIHVLKGISLELKAGDKIALVGSSGCGKSTIVNLLQRFYDPTKGRVLI 453

Query: 2105 DDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFV 2284
            D  D+R+++V  LR+ I +V QEP LF+ TI ENI  G E+ T DQV +A  +AN + F+
Sbjct: 454  DGVDLREVNVHSLREQIGIVSQEPVLFDGTIYENIKMGNEHATHDQVVEACKMANANDFI 513

Query: 2285 MGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEAL 2464
              LPDGY T VG  G +LSGGQKQR+AIARA+V++PKILLLDEATSALDTE+E+ VQ AL
Sbjct: 514  KRLPDGYGTRVGEKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQGAL 573

Query: 2465 DKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
            D+A+ GRT +++AHRLSTI+N D+I V + G  +E G+H+ L++++G++Y + + Q
Sbjct: 574  DQAQAGRTTIIVAHRLSTIRNVDRIFVFKAGNIVESGSHEELMSKQGIFYDMTQAQ 629



 Score =  246 bits (628), Expect = 2e-63
 Identities = 132/228 (57%), Positives = 162/228 (70%), Gaps = 1/228 (0%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            + K+L+G + ++  G+TVALVGHSGCGKST +GLL RFYNQ  GMI +DG  I+  NI
Sbjct: 1059 DTKVLQGFTLDIKAGKTVALVGHSGCGKSTIMGLLERFYNQDKGMIMIDGDNIRNLNISS 1118

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMG-DVLITDQDIEEACKMANAHEFICKLSDRYDTVI 358
            LR  + IV QEP +F  T+ ENI  G +  +T Q+I EA KMAN H FI  L D YDT +
Sbjct: 1119 LREQVCIVSQEPTLFDCTIGENICYGTNRNVTYQEIVEAAKMANIHNFILGLPDGYDTHV 1178

Query: 359  GAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLC 538
            G    QLSGGQKQR+AIARA+VR P +LLLDEATSALDTESE++VQ ALD A +GRT L
Sbjct: 1179 GEKGTQLSGGQKQRIAIARALVRSPSVLLLDEATSALDTESEKIVQEALDAAKQGRTCLV 1238

Query: 539  IAHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEI 682
            IAHRLSTI+N+  I +  +G I E+GTHDELI K + IY    + Q I
Sbjct: 1239 IAHRLSTIQNSDVIAIVSEGKIVEKGTHDELIRKSE-IYQKFCETQRI 1285


>gi|833699|gb|AAA75000.1| multidrug resistance protein
 gi|1098061|prf||2115220A P-glycoprotein
          Length = 1287

 Score =  669 bits (1726), Expect = 0.0
 Identities = 369/887 (41%), Positives = 552/887 (61%), Gaps = 10/887 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            ++++LKG++  +  G+TVALVG SGCGKST++ L+ RFY+   G+I LDG  I+  NIR+
Sbjct: 416  DIQVLKGLNLNIPSGKTVALVGSSGCGKSTTVQLIQRFYDPEDGVITLDGQDIRSLNIRY 475

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  IG+V QEPI+F  T+A+NIR G   +T ++IE A K ANA++FI KL D+ +T++G
Sbjct: 476  LREIIGVVSQEPILFDTTIADNIRYGREDVTKEEIERATKEANAYDFIMKLPDKLETLVG 535

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ+ALDKA EGRTT+ +
Sbjct: 536  ERGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQSALDKAREGRTTIVV 595

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
            AHRLSTIRNA+ I  FD G+I E+G+H EL+ +  G+Y ++V  Q +E +
Sbjct: 596  AHRLSTIRNANAIAGFDNGVIVEQGSHKELMERG-GVYFNLVTLQTVETS---------- 644

Query: 722  XXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTT-TQVPXXXXXXXXXXXXXX- 895
                 +    D  T   E+++  +    +   R+S  +T  ++VP
Sbjct: 645  -----KDTEEDLETHIYEKKIPVTHTHSNLVRRKSSRNTIKSKVPETEDKEVDEEEKKKE 699

Query: 896  -GAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIK 1072
             G    S F + K   PE    ++ ++  +I G T PAF+I++ ++  + +     +  +
Sbjct: 700  EGPPPVSFFKVMKLNKPEWPYFVVGVICAMINGATQPAFAIIFSRIIGVFAGPVSQMRSE 759

Query: 1073 ALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNV 1252
            + + SL F+ L     I+  + G   GKAGE ++ RLR+  F+++++Q+  +FDDS+++
Sbjct: 760  SSMYSLLFLALGGVSFITFFLQGFTFGKAGEILTMRLRLGSFKSMLRQEIGWFDDSKNST 819

Query: 1253 GSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXX 1432
            G+LT+RLATDA  VQ A   RLA +   + +L   + ++F YGW +  +
Sbjct: 820  GALTTRLATDASQVQGATGTRLALLAQNVANLGTAIIISFIYGWQLTLLILAIVPVIAAA 879

Query: 1433 XXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRA 1612
                        ++D     +A ++ T+++ N +TV +LT++      +  + + P+R +
Sbjct: 880  GLVEMKMFAGHAKKDKKELEKAGKISTDAVLNIRTVVSLTRERKFEAMYEKSLEGPYRNS 939

Query: 1613 IVRGLWQSLSFALAGSF----VMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMS 1780
            I +     L++ L+ +     + W F++    G +L+         VF V  A+ + +M+
Sbjct: 940  IKKAHLHGLTYGLSQAHHVLCLCWVFSV---LGAYLVVEGLMKLDEVFLVSSAIVLGAMA 996

Query: 1781 VMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYPNR 1957
            +   +S+ P+Y +A ISA  +F+++ +   ID+    G+ P    GN+  +GV F YP R
Sbjct: 997  LGQTSSFAPDYTKAMISAAHIFSLLERVPQIDSYSDQGEKPKNCSGNVVFKGVNFNYPTR 1056

Query: 1958 RRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVK 2137
                VL G ++S   G+T+ALVG SGCGKSTT+ L+ER+YD   G V +D   +R+L+++
Sbjct: 1057 PDITVLQGLDISVKQGETLALVGSSGCGKSTTVSLLERFYDPFEGEVLVDGLSVRNLNIQ 1116

Query: 2138 HLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYDT 2311
             +R  + +V QEP LF+ +I +NI YG  N  +TQ+++E AA  ANIH+F+  L D Y+T
Sbjct: 1117 WVRAQMGIVSQEPILFDCSIGDNIAYGDNNRKVTQEEIETAAKEANIHSFIESLTDKYNT 1176

Query: 2312 SVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTC 2491
             VG  G +LSGGQKQR+AIARA++R PKILLLDEATSALDTESEK+VQEALDKAR+GRTC
Sbjct: 1177 RVGDKGTQLSGGQKQRIAIARALIRKPKILLLDEATSALDTESEKVVQEALDKARMGRTC 1236

Query: 2492 VVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
            +VIAHRLSTIQNADKI V +NGK +E+GTHQ LL  +G+Y+ LV  Q
Sbjct: 1237 IVIAHRLSTIQNADKIAVIQNGKVVEQGTHQQLLQLKGVYFSLVTIQ 1283



 Score =  330 bits (845), Expect = 1e-88
 Identities = 200/595 (33%), Positives = 329/595 (54%), Gaps = 18/595 (3%)
 Frame = +2

Query: 905  EASLFDIFKYASPEMRNIII-SLVFTLIRGFTWPAFSIVYGQLF-KILSAGGDDV---SI 1069
            +  +F +F+Y+S   + +++   + +L  G   P   +V+G++    ++ G  D    +
Sbjct: 48   KVGVFTMFRYSSTSDKMLMLFGTIASLAHGAALPLMMLVFGEMTDSFVNVGQVDTGNFTW 107

Query: 1070 KALLNS------------LWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQ 1213
            ++++N+             ++  L F   +   I  S    +      ++R + F  +++
Sbjct: 108  ESMINASRELQGQMTTYAYYYSGLGFGVMLCAYIQISFWTLSAGRQIKKIRSNFFHAVLR 167

Query: 1214 QDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMA 1393
            Q+  +FD +  + G L +RL  D   +   I  ++A +L  + +L  G  + F  GW +
Sbjct: 168  QEIGWFDIN--DAGELNTRLTDDVSKINEGIGDKIAMLLQSLTTLVTGFIIGFIKGWKLT 225

Query: 1394 PIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYD 1573
             +                  L     +++ +  +A  +  E +S+ +TV A   Q
Sbjct: 226  WVMGAISPIMGLSAAIWAKVLSAFTNKELKAYAKAGAVAEEVLSSIRTVFAFGGQNKEIH 285

Query: 1574 AFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVI 1753
             +    +   +  I + +  ++S   A   +   +++A+ +G  LI +   T  +V  V
Sbjct: 286  RYEKNLEDAKKIGIKKAITANVSIGFAFLMIYAAYSLAFWYGTTLIIDGGYTIGSVLTVF 345

Query: 1754 EALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMR 1930
             A+ + + +V   +     +  AR +A  +F +I  +  ID+    G  P  IKG+I  +
Sbjct: 346  FAVIIGAFAVGQTSPNIEAFANARGAAYTIFNIIDNQPKIDSFSKEGLKPDKIKGDIEFK 405

Query: 1931 GVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDD 2110
             V F YP+R+   VL G N++   G+TVALVG SGCGKSTT+QLI+R+YD   G + +D
Sbjct: 406  NVIFTYPSRKDIQVLKGLNLNIPSGKTVALVGSSGCGKSTTVQLIQRFYDPEDGVITLDG 465

Query: 2111 SDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMG 2290
             DIR L++++LR+ I +V QEP LF+ TI +NI YG E++T++++E+A   AN + F+M
Sbjct: 466  QDIRSLNIRYLREIIGVVSQEPILFDTTIADNIRYGREDVTKEEIERATKEANAYDFIMK 525

Query: 2291 LPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDK 2470
            LPD  +T VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +VQ ALDK
Sbjct: 526  LPDKLETLVGERGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQSALDK 585

Query: 2471 ARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            AR GRT +V+AHRLSTI+NA+ I    NG  +E+G+H+ L+ R G+Y+ LV  Q+
Sbjct: 586  AREGRTTIVVAHRLSTIRNANAIAGFDNGVIVEQGSHKELMERGGVYFNLVTLQT 640


>gi|6755046|ref|NP_035205.1| ATP-binding cassette, sub-family B
            (MDR/TAP), member 1B; P glycoprotein 1 [Mus musculus]
 gi|126927|sp|P06795|MDR1_MOUSE Multidrug resistance protein 1
            (P-glycoprotein 1)
 gi|72474|pir||DVMS1 multidrug resistance protein 1 - mouse
 gi|387426|gb|AAA79005.1| multidrug resistance protein
          Length = 1276

 Score =  668 bits (1723), Expect = 0.0
 Identities = 369/884 (41%), Positives = 549/884 (61%), Gaps = 9/884 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            E++ILKG++ +V  G+TVALVG+SGCGKST++ L+ R Y+   G++ +DG  I+  N+R+
Sbjct: 405  EVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLEGVVSIDGQDIRTINVRY 464

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  IG+V QEP++F  T+AENIR G   +T  +IE+A K ANA++FI KL  ++DT++G
Sbjct: 465  LREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVG 524

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA EGRTT+ I
Sbjct: 525  ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVI 584

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ----EIERAXXXXXX 709
            AHRLST+RNA  I  FD G+I E+G HDEL+ ++ GIY  +V  Q    EIE
Sbjct: 585  AHRLSTVRNADVIAGFDGGVIVEQGNHDELM-REKGIYFKLVMTQTRGNEIEPG------ 637

Query: 710  XXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXX 889
                    + ++   S T   E   ++S    S  +R+S+  +  +
Sbjct: 638  --------NNAYGSQSDTDASELTSEES---KSPLIRRSIYRSVHRKQDQERRLSMKEAV 686

Query: 890  XXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSI 1069
                   S + I      E   +++ ++  +I G   P F+IV+ ++  + S   D  +
Sbjct: 687  DEDVPLVSFWRILNLNLSEWPYLLVGVLCAVINGCIQPVFAIVFSRIVGVFSRDDDHETK 746

Query: 1070 KALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSR 1243
            +   N  SL+F+++     ++    G   GKAGE ++ R+R  VF+++++QD S+FDD +
Sbjct: 747  RQNCNLFSLFFLVMGLISFVTYFFQGFTFGKAGEILTKRVRYMVFKSMLRQDISWFDDHK 806

Query: 1244 HNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXX 1423
            ++ GSLT+RLA+DA +V+ A+  RLA V   + +L  GV ++  YGW +  +
Sbjct: 807  NSTGSLTTRLASDASSVKGAMGARLAVVTQNVANLGTGVILSLVYGWQLTLLLVVIIPLI 866

Query: 1424 XXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPH 1603
                      L  +  +D      + ++ TE+I N++T+ +LT+++     +  + + P+
Sbjct: 867  VLGGIIEMKLLSGQALKDKKQLEISGKIATEAIENFRTIVSLTREQKFETMYAQSLQVPY 926

Query: 1604 RRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSV 1783
            R A+ +     ++F+   + + +++A  + FG +L++    T   V  V  A+   +M+
Sbjct: 927  RNAMKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVAQQLMTFENVMLVFSAVVFGAMAA 986

Query: 1784 MLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFAYPNRR 1960
               +S+ P+Y +A++SA  +  +I +   ID+    G  PT ++GN+   GV F YP R
Sbjct: 987  GNTSSFAPDYAKAKVSASHIIRIIEKTPEIDSYSTEGLKPTLLEGNVKFNGVQFNYPTRP 1046

Query: 1961 RQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKH 2140
               VL G ++    GQT+ALVG SGCGKST +QL+ER+YD + GSV +D  +I+ L+V+
Sbjct: 1047 NIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQW 1106

Query: 2141 LRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYDTS 2314
            LR ++ +V QEP LF+ +I ENI YG  +  ++ +++ +AA  ANIH F+  LPD Y+T
Sbjct: 1107 LRAHLGIVSQEPILFDCSIAENIAYGDNSRAVSHEEIVRAAKEANIHQFIDSLPDKYNTR 1166

Query: 2315 VGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCV 2494
            VG  G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GRTC+
Sbjct: 1167 VGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCI 1226

Query: 2495 VIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVE 2626
            VIAHRLSTIQNAD I+V  NGK  E GTHQ LLA++G+Y+ +V+
Sbjct: 1227 VIAHRLSTIQNADLIVVIENGKVKEHGTHQQLLAQKGIYFSMVQ 1270



 Score =  338 bits (866), Expect = 5e-91
 Identities = 212/597 (35%), Positives = 317/597 (52%), Gaps = 23/597 (3%)
 Frame = +2

Query: 914  LFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLF------------KILSAGG 1054
            +F +F+YA   +   +I+  +  +I G   P   +V+G +              I +  G
Sbjct: 35   VFGMFRYADWLDKLCMILGTLAAIIHGTLLPLLMLVFGNMTDSFTKAEASILPSITNQSG 94

Query: 1055 DD----VSIKALLNSLWFILLAFTG-GISTLISG----SLLGKAGETMSGRLRMDVFRNI 1207
             +    +S  +L   +      +TG G   LI      SL   A      ++R   F  I
Sbjct: 95   PNSTLIISNSSLEEEMAIYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAI 154

Query: 1208 MQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWN 1387
            M Q+  +FD   H+VG L +RL  D   +   I  ++      I +   G  + F  GW
Sbjct: 155  MNQEIGWFDV--HDVGELNTRLTDDVSKINDGIGDKIGMFFQSITTFLAGFIIGFISGWK 212

Query: 1388 MAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYM 1567
            +  +                  L     +++ +  +A  +  E ++  +TV A   Q+
Sbjct: 213  LTLVILAVSPLIGLSSALWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQQKE 272

Query: 1568 YDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQ 1747
             + +    +      I + +  S+S  +A   V  ++A+A+ +G  L+ +N  +   V
Sbjct: 273  LERYNKNLEEAKNVGIKKAITASISIGIAYLLVYASYALAFWYGTSLVLSNEYSIGEVLT 332

Query: 1748 VIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNIN 1924
            V  ++ + + S+   A     +  AR +A  +F +I  +  ID+    G  P +I GN+
Sbjct: 333  VFFSILLGTFSIGHLAPNIEAFANARGAAFEIFKIIDNEPSIDSFSTKGYKPDSIMGNLE 392

Query: 1925 MRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKI 2104
             + V+F YP+R    +L G N+    GQTVALVG SGCGKSTT+QL++R YD L G V I
Sbjct: 393  FKNVHFNYPSRSEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLEGVVSI 452

Query: 2105 DDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFV 2284
            D  DIR ++V++LR+ I +V QEP LF  TI ENI YG E++T D++EKA   AN + F+
Sbjct: 453  DGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFI 512

Query: 2285 MGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEAL 2464
            M LP  +DT VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +VQ AL
Sbjct: 513  MKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAAL 572

Query: 2465 DKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            DKAR GRT +VIAHRLST++NAD I     G  +E+G H  L+  +G+Y++LV  Q+
Sbjct: 573  DKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQT 629


>gi|2149087|gb|AAB58489.1| multidrug resistance protein-1 [Ovis aries]
          Length = 1285

 Score =  667 bits (1722), Expect = 0.0
 Identities = 370/887 (41%), Positives = 547/887 (60%), Gaps = 9/887 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            E+KILKG++ +V  G+TVALVG+SGCGKST++ L+ R Y+   GM+ +DG  I+  N+R+
Sbjct: 411  EVKILKGLNLKVGSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSIDGQDIRTINVRY 470

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  IG+V QEP++F  T+AENIR G   +T  +I++A K ANA++FI KL +++DT++G
Sbjct: 471  LREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIQKAVKEANAYDFIMKLPNKFDTLVG 530

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                QLSGGQKQR+AIARA+VR P+ILLLDEATSAL TESE +VQ ALDKA +GRTT+ I
Sbjct: 531  ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALGTESEAVVQAALDKARKGRTTIVI 590

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMV----KAQEIERAXXXXXX 709
            AHRLST+RNA  I   D G+I E G+HDEL+ K  GIY  +V    K  E+E
Sbjct: 591  AHRLSTVRNADIIAGLDDGVIVEEGSHDELMGKR-GIYFKLVTMQTKGNELELENTPG-- 647

Query: 710  XXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXX 889
                          +S++  ++  +    +R S   R+S   +
Sbjct: 648  --------------ESLSKTDDLYMSSQDSRSSLIRRKSTRRSIRGSQSQDRKLSTEETL 693

Query: 890  XXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSI 1069
                   S + I K    E    ++ +   +I G   PAFS+++ ++  I +   +D +
Sbjct: 694  DESVPPVSFWRILKLNITEWPYFVVGVFCAIINGALQPAFSVIFSRIIGIFTRNDNDETK 753

Query: 1070 KALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSR 1243
            +   N  SL F++L     I+  + G   GKAGE ++ RLR  VFR++++QD S+FDD +
Sbjct: 754  RQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTRRLRYLVFRSMLRQDVSWFDDPK 813

Query: 1244 HNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXX 1423
            +  G+LT+RLA DA  V+ A+  RLA +   I +L  G+ ++  YGW +  +
Sbjct: 814  NTTGALTTRLANDAAQVKGAVGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPII 873

Query: 1424 XXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPH 1603
                      L  +  +D      A ++ TE+I N++TV +LT++E     +  + + P+
Sbjct: 874  AVAGVIEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTREERFEYMYAQSLQVPY 933

Query: 1604 RRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSV 1783
            R ++ R     ++F++  + + +++A  + FG +L++        V  V  A+   +M+V
Sbjct: 934  RNSLRRAHVFGITFSITQAMMYFSYAGCFRFGAYLVAQGIMEFQDVLLVFSAVVFGAMAV 993

Query: 1784 MLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYPNRR 1960
               +++ P+Y +A++SA  +  +I +  +ID+    G  P T++G++    V F YP R
Sbjct: 994  GQVSTFAPDYAKAKVSAAHVINIIEKIPLIDSYSTEGLKPSTVEGSVAFNDVVFNYPTRP 1053

Query: 1961 RQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKH 2140
               VL G ++    GQT+ALVG SGCGKST +QL+ER+YD L G+V ID  +++ L+V+
Sbjct: 1054 DVPVLRGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFIDGKEVKQLNVQW 1113

Query: 2141 LRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYDTS 2314
            LR ++ +V QEP LF+ +I ENI YG  +  ++Q+++E AA  ANIH+F+  LPD Y+T
Sbjct: 1114 LRAHMGIVSQEPILFDCSIGENIAYGDNSRVVSQEEIEHAAKEANIHSFIEMLPDKYNTR 1173

Query: 2315 VGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCV 2494
            VG  G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GRTC+
Sbjct: 1174 VGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCI 1233

Query: 2495 VIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            VIAHRLSTIQNAD I+V +NG+  E GTHQ LLA++G+Y+ +V  Q+
Sbjct: 1234 VIAHRLSTIQNADLIVVFQNGRIKEHGTHQQLLAQKGIYFTMVSVQA 1280



 Score =  346 bits (887), Expect = 2e-93
 Identities = 214/599 (35%), Positives = 322/599 (53%), Gaps = 24/599 (4%)
 Frame = +2

Query: 911  SLFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSI------ 1069
            S F +F+Y++  +   +++  +  +I G   P   +V+G +    +  G+  +I
Sbjct: 39   STFTMFRYSNWLDRLCMVLGTLAAIIHGAGLPLMMLVFGDMTDSFAGAGNLGNITLSNIS 98

Query: 1070 -----------KALLNSLWFILLAFTG-GISTLISG----SLLGKAGETMSGRLRMDVFR 1201
                       K L   +      ++G G   LI+     S    A      R+R   F
Sbjct: 99   NTSTIDRTEYGKKLEKEMTTYAYYYSGIGAGVLIAAYIQVSFWCLAAGRQVHRIRKQFFH 158

Query: 1202 NIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYG 1381
             IMQQ+  +FD   H+VG L +RL  D   +   I  ++      + + F G  + F  G
Sbjct: 159  AIMQQEIGWFDV--HDVGKLNTRLTNDVSKINEGIGDKIGMFFQAMATFFTGFIIGFTTG 216

Query: 1382 WNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQE 1561
            WN+  +                  L     + + +  +A  +  E ++  KTV A   Q+
Sbjct: 217  WNLTLVILAIIPVLGLSAAIWAKILSSFTDKKLLAYAKAGAVAEEVLAAIKTVIAFGGQK 276

Query: 1562 YMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTV 1741
               + +    +   R  I + +  ++S   A   +  ++A+A+ +G  L+ +   +   V
Sbjct: 277  KELERYNKNLEEAKRIGIKKAITANISMGAAFLLIYASYALAFWYGTSLVLSREYSIGQV 336

Query: 1742 FQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGN 1918
              V  ++ + + S+  A+     +  AR +A  +F +I  K  ID+   TG  P  IKGN
Sbjct: 337  LTVFFSVLIGAFSIGQASPNIEAFANARGAAYEVFKIIDNKPSIDSYSNTGHKPDNIKGN 396

Query: 1919 INMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSV 2098
            +  R V+F YP+R    +L G N+    GQTVALVG SGCGKSTT+QL++R YD   G V
Sbjct: 397  LEFRNVHFHYPSRNEVKILKGLNLKVGSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMV 456

Query: 2099 KIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHT 2278
             ID  DIR ++V++LR+ I +V QEP LF  TI ENI YG E++T D+++KA   AN +
Sbjct: 457  SIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIQKAVKEANAYD 516

Query: 2279 FVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQE 2458
            F+M LP+ +DT VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSAL TESE +VQ
Sbjct: 517  FIMKLPNKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALGTESEAVVQA 576

Query: 2459 ALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            ALDKAR GRT +VIAHRLST++NAD I    +G  +EEG+H  L+ +RG+Y++LV  Q+
Sbjct: 577  ALDKARKGRTTIVIAHRLSTVRNADIIAGLDDGVIVEEGSHDELMGKRGIYFKLVTMQT 635


>gi|39587987|emb|CAE57218.1| Hypothetical protein CBG00078
            [Caenorhabditis briggsae]
          Length = 1282

 Score =  667 bits (1722), Expect = 0.0
 Identities = 374/894 (41%), Positives = 536/894 (59%), Gaps = 17/894 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            + KIL G++  + PG +VALVGHSGCGKSTS+GLL R Y    G + +DG  ++E NI +
Sbjct: 389  DAKILNGLNLTIEPGTSVALVGHSGCGKSTSVGLLTRLYEPETGNVTIDGTDVRELNIDY 448

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR+ +GIVQQEPI+F  T+  N+ +G+     + + E CKMANAH+FI K+   YDT+IG
Sbjct: 449  LRNVVGIVQQEPILFNDTIHNNLLLGNPNAKREKMIEVCKMANAHDFIEKMPKGYDTLIG 508

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
             G VQLSGGQKQRVAIAR ++R P++LLLDEATSALD +SE +VQ+AL+ AS+GRTT+ I
Sbjct: 509  DGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALNNASKGRTTIMI 568

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEI-----------ER 688
            AHRLSTIR A  I+ F++G+I E G H EL+ + +G Y  +VKAQ             E
Sbjct: 569  AHRLSTIREADMIVFFEKGVIVEAGNHAELV-RLEGRYYDLVKAQAFKPDDNPISQYDEI 627

Query: 689  AXXXXXXXXXXXXXXHRSFHRDSVTS---DEERELQQSLARDSTRLRQSMISTTTQVPXX 859
            A               +S    S+ S     E   + +L  DS    +S      +
Sbjct: 628  AEDIDLGPSATAIHSRQSSFTSSIRSRISGAEAFRRGTLGADSFAGGRSSARADAE-NAA 686

Query: 860  XXXXXXXXXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFK- 1036
                        G + A   DIFK A      +++  V  LIRG    AF++++G +F+
Sbjct: 687  FAEEVAKVMEQDGQISAGFLDIFKNAHGNYTVMLLGFVTGLIRGLELTAFALLFGWVFEG 746

Query: 1037 --ILSAGGDDVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIM 1210
               L+     +  +  +  + +    F   +S  +S        E ++ R R+  FRN++
Sbjct: 747  FQYLTVDNGKMMHRMAMAVIAYGCSGFGCFVSQFLSSVFFAIVSENLALRFRVMSFRNLL 806

Query: 1211 QQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNM 1390
             QDAS+FD+  H  G L +RLATDAPN +  +D R+ +VL  + ++   + +AF Y W +
Sbjct: 807  YQDASFFDNPAHAPGKLITRLATDAPNCKTVVDSRMLQVLYALSAIIANIAIAFIYCWYL 866

Query: 1391 APIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMY 1570
            A +G                 +     + +    EA R+  E I N KT+Q LT+ ++ +
Sbjct: 867  AILGTALIILLAVTMCGLAYKISLLNMKQIQDD-EAGRIAIEIIENVKTIQLLTRCDHFF 925

Query: 1571 DAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQV 1750
            + +  +SKS  R  + +GL +++++ +  SF+ +     +  G+ LI     +   VFQ
Sbjct: 926  ERYQKSSKSQKRSELKKGLIEAVNYTITQSFMYYMMCFCFALGIRLIYQGNKSSQDVFQG 985

Query: 1751 IEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMR 1930
              A+ + +M VM +A YFPE+V+A+ ++G++F +I +K    +  + G  P ++GNI
Sbjct: 986  NIAMLLTAMGVMNSAQYFPEFVKAKTASGLLFNIIYRKPRTGDL-MEGTCPEVRGNILFE 1044

Query: 1931 GVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDD 2110
             V F+YP R  Q ++ G   +A  GQTVALVGPSG GKST I ++ER+YD   G ++ID
Sbjct: 1045 DVKFSYPQRPHQPIMKGLQWTALRGQTVALVGPSGSGKSTCIGMLERFYDVTGGVLRIDG 1104

Query: 2111 SDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMG 2290
             DIR LS+ HLR  +ALVGQEP LF  TI+ENI  GLEN++ +++  A  LAN + F+
Sbjct: 1105 QDIRGLSLFHLRTQMALVGQEPRLFAGTIKENICLGLENVSMEKINHALELANANRFLSN 1164

Query: 2291 LPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDK 2470
            LP G +T VG  G +LSGGQKQR+AIARA+VRDPKILLLDEATSALD+ESEK VQEALD+
Sbjct: 1165 LPAGIETDVGEKGSKLSGGQKQRIAIARALVRDPKILLLDEATSALDSESEKAVQEALDR 1224

Query: 2471 ARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
            AR GRTC+ IAHRLS+IQN+D I+   NG+  E G H+ L+A++G YY L++KQ
Sbjct: 1225 AREGRTCITIAHRLSSIQNSDVIVYIENGRVQEAGNHKQLMAKKGKYYELIQKQ 1278



 Score =  302 bits (773), Expect = 3e-80
 Identities = 176/521 (33%), Positives = 281/521 (53%), Gaps = 10/521 (1%)
 Frame = +2

Query: 1103 LAFTGGISTLISG-----SLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSLTS 1267
            L F G I  +ISG              +  ++R     ++++Q+A +FD  +++ G++ +
Sbjct: 98   LLFIGIICAIISGISQPYMCFQHCCSRIMAQMRHRYVYSVLRQNAGWFD--KNHSGTIAT 155

Query: 1268 RLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXXXXX 1447
            +L      ++  I  +L  ++ G+  L   + VA+ Y W +A +
Sbjct: 156  KLNDSMERIREGIGDKLGVLIRGVAMLLASIVVAYIYEWRLACMMLGVAPTCVGCMSLMA 215

Query: 1448 XYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVRGL 1627
              +     +++    +A  +  ES+   +TVQA   QE M + +        + AI +G
Sbjct: 216  RQMTATTVKELGGVEKAGSIAEESLMGVRTVQAFNGQEEMVERYRVELNKGRKFAIWKGF 275

Query: 1628 WQSLSFALAGSFVMWNFAI---AYMFGLWLISNNWST-PYTVFQVIEALNMASMSVMLAA 1795
            W  L     G F  W FA     +++G +L+     T P  VF ++ A+ + S  + L +
Sbjct: 276  WSGL---YGGLFFFWLFAFQGCGFLYGAYLLKIGIITSPGDVFIIVMAMLLGSYFLGLIS 332

Query: 1796 SYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD-TPTIKGNINMRGVYFAYPNRRRQLV 1972
             +    + AR++A  ++  I +   ID     G     + G +    V+F YP R+   +
Sbjct: 333  PHLMVLLNARVAAASIYETIERVPKIDPYSKKGRFLDKVIGRVKFENVHFRYPTRKDAKI 392

Query: 1973 LDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDN 2152
            L+G N++   G +VALVG SGCGKST++ L+ R Y+   G+V ID +D+R+L++ +LR+
Sbjct: 393  LNGLNLTIEPGTSVALVGHSGCGKSTSVGLLTRLYEPETGNVTIDGTDVRELNIDYLRNV 452

Query: 2153 IALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGG 2332
            + +V QEP LFN TI  N+  G  N  ++++ +   +AN H F+  +P GYDT +G  G
Sbjct: 453  VGIVQQEPILFNDTIHNNLLLGNPNAKREKMIEVCKMANAHDFIEKMPKGYDTLIGDGGV 512

Query: 2333 RLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRL 2512
            +LSGGQKQRVAIAR ++RDPK+LLLDEATSALD +SE +VQ AL+ A  GRT ++IAHRL
Sbjct: 513  QLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALNNASKGRTTIMIAHRL 572

Query: 2513 STIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            STI+ AD I+    G  +E G H  L+   G YY LV+ Q+
Sbjct: 573  STIREADMIVFFEKGVIVEAGNHAELVRLEGRYYDLVKAQA 613



 Score =  201 bits (511), Expect = 7e-50
 Identities = 106/224 (47%), Positives = 156/224 (69%)
 Frame = +2

Query: 11   ILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWLRS 190
            I+KG+ +    G+TVALVG SG GKST IG+L RFY+   G++++DG  I+  ++  LR+
Sbjct: 1058 IMKGLQWTALRGQTVALVGPSGSGKSTCIGMLERFYDVTGGVLRIDGQDIRGLSLFHLRT 1117

Query: 191  TIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIGAGA 370
             + +V QEP +F  T+ ENI +G   ++ + I  A ++ANA+ F+  L    +T +G
Sbjct: 1118 QMALVGQEPRLFAGTIKENICLGLENVSMEKINHALELANANRFLSNLPAGIETDVGEKG 1177

Query: 371  VQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIAHR 550
             +LSGGQKQR+AIARA+VR P+ILLLDEATSALD+ESE+ VQ ALD+A EGRT + IAHR
Sbjct: 1178 SKLSGGQKQRIAIARALVRDPKILLLDEATSALDSESEKAVQEALDRAREGRTCITIAHR 1237

Query: 551  LSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEI 682
            LS+I+N+  I+  + G + E G H +L++K  G Y  +++ Q++
Sbjct: 1238 LSSIQNSDVIVYIENGRVQEAGNHKQLMAK-KGKYYELIQKQDL 1280


>gi|1362689|pir||S55692 multidrug resistance protein homolog (mdr) -
            African clawed frog
          Length = 1287

 Score =  666 bits (1718), Expect = 0.0
 Identities = 368/887 (41%), Positives = 551/887 (61%), Gaps = 10/887 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            ++++LKG++  +  G+TVALVG SGCGKST++ L+ RFY+   G+I LDG  I+  NIR+
Sbjct: 416  DIQVLKGLNLNIPSGKTVALVGSSGCGKSTTVQLIQRFYDPEDGVITLDGQDIRSLNIRY 475

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  IG+V QEPI+F  T+A+NIR G   +T ++IE A K ANA++FI KL D+ +T++G
Sbjct: 476  LREIIGVVSQEPILFDTTIADNIRYGREDVTKEEIERATKEANAYDFIMKLPDKLETLVG 535

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ+ALDKA EGRTT+ +
Sbjct: 536  ERGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQSALDKAREGRTTIVV 595

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
            AHRLSTIRNA+ I  FD G+I E+G+H EL+ +  G+Y ++V  Q +E +
Sbjct: 596  AHRLSTIRNANAIAGFDNGVIVEQGSHKELMERG-GVYFNLVTLQTVETS---------- 644

Query: 722  XXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTT-TQVPXXXXXXXXXXXXXX- 895
                 +    D  T   E+++  +    +   R+S  +T  ++VP
Sbjct: 645  -----KDTEEDLETHIYEKKIPVTHTHSNLVRRKSSRNTIKSKVPETEDKEVDEEEKKKE 699

Query: 896  -GAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIK 1072
             G    S F + K   PE    ++ ++  +I G T PAF+I++ ++  + +     +  +
Sbjct: 700  EGPPPVSFFKVMKLNKPEWPYFVVGVICAMINGATQPAFAIIFSRIIGVFAGPVSQMRSE 759

Query: 1073 ALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNV 1252
            + + SL F+ L     I+  +     GKAGE ++ RLR+  F+++++Q+  +FDDS+++
Sbjct: 760  SSMYSLLFLALGGVSFITFFLQRFTFGKAGEILTMRLRLGSFKSMLRQEIGWFDDSKNST 819

Query: 1253 GSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXX 1432
            G+LT+RLATDA  VQ A   RLA +   + +L   + ++F YGW +  +
Sbjct: 820  GALTTRLATDASQVQGATGTRLALLAQNVANLGTAIIISFIYGWQLTLLILAIVPVIAAA 879

Query: 1433 XXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRA 1612
                        ++D     +A ++ T+++ N +TV +LT++      +  + + P+R +
Sbjct: 880  GLVEMKMFAGHAKKDKKELEKAGKISTDAVLNIRTVVSLTRERKFEAMYEKSLEGPYRNS 939

Query: 1613 IVRGLWQSLSFALAGSF----VMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMS 1780
            I +     L++ L+ +     + W F++    G +L+         VF V  A+ + +M+
Sbjct: 940  IKKAHLHGLTYGLSQAHHVLCLCWVFSV---LGAYLVVEGLMKLDEVFLVSSAIVLGAMA 996

Query: 1781 VMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYPNR 1957
            +   +S+ P+Y +A ISA  +F+++ +   ID+    G+ P    GN+  +GV F YP R
Sbjct: 997  LGQTSSFAPDYTKAMISAAHIFSLLERVPQIDSYSDQGEKPKNCSGNVVFKGVNFNYPTR 1056

Query: 1958 RRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVK 2137
                VL G ++S   G+T+ALVG SGCGKSTT+ L+ER+YD   G V +D   +R+L+++
Sbjct: 1057 PDITVLQGLDISVKQGETLALVGSSGCGKSTTVSLLERFYDPFEGEVLVDGLSVRNLNIQ 1116

Query: 2138 HLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYDT 2311
             +R  + +V QEP LF+ +I +NI YG  N  +TQ+++E AA  ANIH+F+  L D Y+T
Sbjct: 1117 WVRAQMGIVSQEPILFDCSIGDNIAYGDNNRKVTQEEIETAAKEANIHSFIESLTDKYNT 1176

Query: 2312 SVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTC 2491
             VG  G +LSGGQKQR+AIARA++R PKILLLDEATSALDTESEK+VQEALDKAR+GRTC
Sbjct: 1177 RVGDKGTQLSGGQKQRIAIARALIRKPKILLLDEATSALDTESEKVVQEALDKARMGRTC 1236

Query: 2492 VVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
            +VIAHRLSTIQNADKI V +NGK +E+GTHQ LL  +G+Y+ LV  Q
Sbjct: 1237 IVIAHRLSTIQNADKIAVIQNGKVVEQGTHQQLLQLKGVYFSLVTIQ 1283



 Score =  330 bits (845), Expect = 1e-88
 Identities = 200/595 (33%), Positives = 329/595 (54%), Gaps = 18/595 (3%)
 Frame = +2

Query: 905  EASLFDIFKYASPEMRNIII-SLVFTLIRGFTWPAFSIVYGQLF-KILSAGGDDV---SI 1069
            +  +F +F+Y+S   + +++   + +L  G   P   +V+G++    ++ G  D    +
Sbjct: 48   KVGVFTMFRYSSTSDKMLMLFGTIASLAHGAALPLMMLVFGEMTDSFVNVGQVDTGNFTW 107

Query: 1070 KALLNS------------LWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQ 1213
            ++++N+             ++  L F   +   I  S    +      ++R + F  +++
Sbjct: 108  ESMINASRELQGQMTTYAYYYSGLGFGVMLCAYIQISFWTLSAGRQIKKIRSNFFHAVLR 167

Query: 1214 QDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMA 1393
            Q+  +FD +  + G L +RL  D   +   I  ++A +L  + +L  G  + F  GW +
Sbjct: 168  QEIGWFDIN--DAGELNTRLTDDVSKINEGIGDKIAMLLQSLTTLVTGFIIGFIKGWKLT 225

Query: 1394 PIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYD 1573
             +                  L     +++ +  +A  +  E +S+ +TV A   Q
Sbjct: 226  WVMGAISPIMGLSAAIWAKVLSAFTNKELKAYAKAGAVAEEVLSSIRTVFAFGGQNKEIH 285

Query: 1574 AFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVI 1753
             +    +   +  I + +  ++S   A   +   +++A+ +G  LI +   T  +V  V
Sbjct: 286  RYEKNLEDAKKIGIKKAITANVSIGFAFLMIYAAYSLAFWYGTTLIIDGGYTIGSVLTVF 345

Query: 1754 EALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMR 1930
             A+ + + +V   +     +  AR +A  +F +I  +  ID+    G  P  IKG+I  +
Sbjct: 346  FAVIIGAFAVGQTSPNIEAFANARGAAYTIFNIIDNQPKIDSFSKEGLKPDKIKGDIEFK 405

Query: 1931 GVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDD 2110
             V F YP+R+   VL G N++   G+TVALVG SGCGKSTT+QLI+R+YD   G + +D
Sbjct: 406  NVIFTYPSRKDIQVLKGLNLNIPSGKTVALVGSSGCGKSTTVQLIQRFYDPEDGVITLDG 465

Query: 2111 SDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMG 2290
             DIR L++++LR+ I +V QEP LF+ TI +NI YG E++T++++E+A   AN + F+M
Sbjct: 466  QDIRSLNIRYLREIIGVVSQEPILFDTTIADNIRYGREDVTKEEIERATKEANAYDFIMK 525

Query: 2291 LPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDK 2470
            LPD  +T VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +VQ ALDK
Sbjct: 526  LPDKLETLVGERGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQSALDK 585

Query: 2471 ARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            AR GRT +V+AHRLSTI+NA+ I    NG  +E+G+H+ L+ R G+Y+ LV  Q+
Sbjct: 586  AREGRTTIVVAHRLSTIRNANAIAGFDNGVIVEQGSHKELMERGGVYFNLVTLQT 640


>gi|39587992|emb|CAE57223.1| Hypothetical protein CBG00086
            [Caenorhabditis briggsae]
          Length = 1316

 Score =  665 bits (1716), Expect = 0.0
 Identities = 370/886 (41%), Positives = 537/886 (59%), Gaps = 11/886 (1%)
 Frame = +2

Query: 8    KILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWLR 187
            K+L G++  + PG +VALVGHSGCGKSTS+GLL R Y Q  G + +DG  ++  NI WLR
Sbjct: 433  KVLNGLNLTIEPGTSVALVGHSGCGKSTSVGLLTRLYEQEDGKVMIDGHEVRNLNIDWLR 492

Query: 188  STIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIGAG 367
              +GIVQQEPI+F  T+  N+ +G+   T  D+   CKMANAHEFI K+   YDTVIG G
Sbjct: 493  KVVGIVQQEPILFSGTIHNNLLIGNPNATRDDMIRVCKMANAHEFILKMPKGYDTVIGDG 552

Query: 368  AVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIAH 547
             VQLSGGQKQRVAIAR ++R P++LLLDEATSALD +SE +VQ+AL+ AS+GRTT+ IAH
Sbjct: 553  GVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALNNASKGRTTIMIAH 612

Query: 548  RLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQE----------IERAXX 697
            RLSTIR A KI+ F+ G+I E GTHDEL++   G YA++VKAQ+          +E
Sbjct: 613  RLSTIREADKIVFFESGVIVESGTHDELVALG-GRYAALVKAQQFKEADEVDDDVEEDIT 671

Query: 698  XXXXXXXXXXXXHRSFHRDSVT-SDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXX 874
                          S+H   V+ +  + E+  + A +S  L+Q+      +
Sbjct: 672  ARIFSEKQMPSRQVSYHGSCVSLASADLEIGYASAFNSFNLKQAQDDIENE---DFAEEV 728

Query: 875  XXXXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGG 1054
                   G + +  +DIFK A      + +  VF ++RG      +I++G +F+
Sbjct: 729  QRVMEEDGVITSGYYDIFKNAKGNYWYLSMGTVFAIMRGSELALLAIMFGYVFEAFEKPD 788

Query: 1055 DDVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFD 1234
             +++ + ++  + +  L     I+ ++S +L     E +  + R+  F+N++ QDAS+FD
Sbjct: 789  AEMARELVIIFILYGCLGLYVFITQVLSSTLFTIVAENLGLKFRVQSFKNLLYQDASFFD 848

Query: 1235 DSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXX 1414
            +  H  G L +RLATDAPNV+A +D R+ +V+  + S+   +   +   W +A +G
Sbjct: 849  NPAHAPGKLITRLATDAPNVKAVVDTRMLQVIYSMTSITINLVTGYACCWQIAVVGTVMI 908

Query: 1415 XXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASK 1594
                        Y   R         EA ++  E + N KT+Q LT  E+    +T A +
Sbjct: 909  ALFALLMISMA-YKIARVNLKQIKRDEAGKIAIEIVENVKTIQLLTSTEHFLTEYTTALE 967

Query: 1595 SPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMAS 1774
              H+  + +   Q+L+ A++ +F+ +   + Y  G  L+ N    P   F+ I ++ M S
Sbjct: 968  LQHKSEMKKAYIQALNNAISQTFMYFAMFVCYAVGTPLMYNGIVDPNGAFRAINSMMMGS 1027

Query: 1775 MSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPN 1954
            ++VM ++  FPE+V+A+ +AG++F +I +K    +  + G+   I+GNI    V F+YP
Sbjct: 1028 VAVMHSSHNFPEFVKAKTAAGMLFKLIYRKPKTGDV-MKGNQLDIRGNILFESVKFSYPQ 1086

Query: 1955 RRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSV 2134
            R    V+   + +A  GQTVALVGPSG GKST I ++ER+YD   G+++ID  DI+ LS+
Sbjct: 1087 RPLHPVMTDLHFTARNGQTVALVGPSGTGKSTCIAMLERFYDVSGGALRIDGQDIKTLSL 1146

Query: 2135 KHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTS 2314
             HLR  +ALVGQEP LF  TIREN+ +GL+++  ++V +A  LAN   F+  LP G DT
Sbjct: 1147 HHLRTQMALVGQEPRLFAGTIRENVCFGLKDVPIEKVNQALELANASRFLANLPSGIDTE 1206

Query: 2315 VGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCV 2494
            VG  G +LSGGQKQR+AIARA+VRDPKILLLDEATSALD+ESE+++QEALD+AR GRTC+
Sbjct: 1207 VGEKGSQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERVMQEALDRAREGRTCI 1266

Query: 2495 VIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
             IAHRLS+IQN+D I+    GK  E G H  L++ RG YY L++KQ
Sbjct: 1267 TIAHRLSSIQNSDLIVYIDQGKVQEAGNHNHLMSLRGKYYDLIKKQ 1312



 Score =  303 bits (775), Expect = 2e-80
 Identities = 193/587 (32%), Positives = 312/587 (52%), Gaps = 13/587 (2%)
 Frame = +2

Query: 911  SLFDIFKYASPEMRN---IIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALL 1081
            +L  +F++A  E R+   ++I ++ + + G   P   ++ G +   L     +V+    L
Sbjct: 77   TLLGLFRFA--ERRDHIILLIGILLSFLSGVAQPGLGVIAGGMTNTLIVY--NVTSPQFL 132

Query: 1082 NSLWFILLAFTG-GISTLISGSLLGKAGETMSGR----LRMDVFRNIMQQDASYFDDSRH 1246
            +S    +  F G G+  LI   +     + +  R    LR +  ++I++Q+A +FD  ++
Sbjct: 133  DSALMNVYLFGGIGVVVLIINFIQYMCFQNVCIRIVTKLREEYIKSILRQNAGWFD--KN 190

Query: 1247 NVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXX 1426
            + G+LT++L  +   +   I  +L  ++ GIV    G+ ++ +Y W +A +
Sbjct: 191  HSGTLTTKLHDNMERIHEGIGDKLGVLIRGIVMFGTGIVISLFYEWRLALMMMGIGPLCC 250

Query: 1427 XXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHR 1606
                     +     +++    +A  +  ES+   +TVQA   QE M   +TA
Sbjct: 251  ICMSLMSRSMSSYTSKELADVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYTAELGKGKS 310

Query: 1607 RAIVRGLWQSLSFALAGSFVMWNFAIAYMFG----LWLISNNWSTPYTVFQVIEALNMAS 1774
             A+ +GLW      +    +   F     +G     W I  N   P  VF V+ ++ + +
Sbjct: 311  YAVKKGLWGGFFGGIFLLILFTYFGGGIFYGGQLLRWKIIEN---PGDVFIVVFSMLIGA 367

Query: 1775 MSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDT-PTIKGNINMRGVYFAYP 1951
              + L + +    + AR++A  ++ +I +   ID     G     I G +    V+F YP
Sbjct: 368  YFLGLISPHLMVLLNARVAAATIYEVIDRVPEIDAYSNEGQKIDKIVGRVVFENVHFRYP 427

Query: 1952 NRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLS 2131
             R++  VL+G N++   G +VALVG SGCGKST++ L+ R Y+   G V ID  ++R+L+
Sbjct: 428  TRKKAKVLNGLNLTIEPGTSVALVGHSGCGKSTSVGLLTRLYEQEDGKVMIDGHEVRNLN 487

Query: 2132 VKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDT 2311
            +  LR  + +V QEP LF+ TI  N+  G  N T+D + +   +AN H F++ +P GYDT
Sbjct: 488  IDWLRKVVGIVQQEPILFSGTIHNNLLIGNPNATRDDMIRVCKMANAHEFILKMPKGYDT 547

Query: 2312 SVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTC 2491
             +G  G +LSGGQKQRVAIAR ++RDPK+LLLDEATSALD +SE +VQ AL+ A  GRT
Sbjct: 548  VIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALNNASKGRTT 607

Query: 2492 VVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
            ++IAHRLSTI+ ADKI+   +G  +E GTH  L+A  G Y  LV+ Q
Sbjct: 608  IMIAHRLSTIREADKIVFFESGVIVESGTHDELVALGGRYAALVKAQ 654


>gi|25453370|ref|NP_036755.2| P-glycoprotein/multidrug resistance 1;
            ATP-binding cassette, sub-family B (MDR/TAP), member 1
            (P-glycoprotein/multidrug resistance 1); ATP-binding
            cassette sub-family B (MDR/TAP) member 1
            (P-glycoprotein/multidrug resistance 1) [Rattus
            norvegicus]
 gi|19743730|gb|AAL92458.1| ATP-binding cassette protein B1b [Rattus
            norvegicus]
          Length = 1275

 Score =  665 bits (1715), Expect = 0.0
 Identities = 372/886 (41%), Positives = 544/886 (60%), Gaps = 11/886 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            E+KILKG++ +V  G+TVALVG+SGCGKST++ LL R Y+   G + +DG  I+  N+R+
Sbjct: 404  EVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIRTINVRY 463

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  IG+V QEP++F  T+AENIR G   +T  +IE+A K ANA++FI KL  +++T++G
Sbjct: 464  LREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFNTLVG 523

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA EGRTT+ I
Sbjct: 524  ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVI 583

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ----EIERAXXXXXX 709
            AHRLST+RNA  I  FD G+I E+G H+EL+ K+ GIY  +V  Q    EIE
Sbjct: 584  AHRLSTVRNADVIAGFDGGVIVEQGNHEELM-KEKGIYFKLVMTQTRGNEIEPGNNAYES 642

Query: 710  XXXXXXXXHRSFHRDSVTSDEERELQQSLAR--DSTRLRQSMISTTTQVPXXXXXXXXXX 883
                      S    S +    R +++S+ R  D  R   S       VP
Sbjct: 643  QSDTGASELTS--EKSKSPLIRRSIRRSIHRRQDQERRLSSKEDVDEDVPM--------- 691

Query: 884  XXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV 1063
                     S + I K    E   +++ ++  +I G   P F+IV+ ++  + S   D
Sbjct: 692  --------VSFWQILKLNISEWPYLVVGVLCAVINGCIQPVFAIVFSKIVGVFSRDDDHE 743

Query: 1064 SIKALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDD 1237
            + +   N  SL F+++     ++    G   GKAGE ++ RLR  VF+++++QD S+FDD
Sbjct: 744  TKQRNCNLFSLLFLVMGMISFVTYFFQGFAFGKAGEILTKRLRYMVFKSMLRQDISWFDD 803

Query: 1238 SRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXX 1417
             ++  GSLT+RLA+DA NV+ A+  RLA V   + +L  G+ ++  YGW +  +
Sbjct: 804  HKNTTGSLTTRLASDASNVKGAMGSRLAVVTQNVANLGTGIILSLVYGWQLTLLLVVIIP 863

Query: 1418 XXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKS 1597
                        L  +  +D      + ++ TE+I N++TV +LT+++     +  + +
Sbjct: 864  LIVLGGIIEMKLLSGQALKDKKELEISGKIATEAIENFRTVVSLTREQKFETMYAQSLQI 923

Query: 1598 PHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASM 1777
            P+R A+ +     ++FA   + + +++A  + FG +L++    T   V  V  A+   +M
Sbjct: 924  PYRNALKKAHVFGITFAFTQAMIYFSYAACFRFGAYLVARELMTFENVMLVFSAVVFGAM 983

Query: 1778 SVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFAYPN 1954
            +    +S+ P+Y +A++SA  +  +I +   ID+    G  P  ++GN+   GV F YP
Sbjct: 984  AAGNTSSFAPDYAKAKVSASHIIRIIEKIPEIDSYSTEGLKPNWLEGNVKFNGVMFNYPT 1043

Query: 1955 RRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSV 2134
            R    VL G +     GQT+ALVG SGCGKST +QL+ER+Y+ + G+V +D  +I+ L+V
Sbjct: 1044 RPNIPVLQGLSFEVKKGQTLALVGSSGCGKSTVVQLLERFYNPMAGTVFLDGKEIKQLNV 1103

Query: 2135 KHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYD 2308
            + LR ++ +V QEP LF+ +I ENI YG  +  ++ +++ +AA  ANIH F+  LP+ Y+
Sbjct: 1104 QWLRAHLGIVSQEPILFDCSITENIAYGDNSRVVSHEEIVRAAREANIHQFIDSLPEKYN 1163

Query: 2309 TSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRT 2488
            T VG  G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GRT
Sbjct: 1164 TRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRT 1223

Query: 2489 CVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVE 2626
            C+VIAHRLSTIQNAD I+V +NG+  E GTHQ LLA++G+Y+ +V+
Sbjct: 1224 CIVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMVQ 1269



 Score =  335 bits (860), Expect = 3e-90
 Identities = 189/487 (38%), Positives = 279/487 (56%), Gaps = 1/487 (0%)
 Frame = +2

Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
            ++R   F  IM Q+  +FD +  + G L +RL  D   +   I  +L      I +   G
Sbjct: 144  KIRQKFFHAIMNQEIGWFDVN--DAGELNTRLTDDVSKINDGIGDKLGMFFQSITTFSAG 201

Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
              + F  GW +  +                  L     +++ +  +A  +  E ++  +T
Sbjct: 202  FIIGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRT 261

Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
            V A   Q+   + +    +   R  I + +  ++S  +A   V  ++A+A+ +G  L+ +
Sbjct: 262  VIAFGGQKKELERYNKNLEEAKRVGIKKAITANISIGIAYLLVYASYALAFWYGTSLVLS 321

Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
            N  +   V  V  ++ + + S+   A     +  AR +A  +F +I  +  ID+    G
Sbjct: 322  NEYSIGQVLTVFFSILLGTFSIGHLAPNIEAFANARGAAYEIFKIIDNEPSIDSFSTKGH 381

Query: 1898 TP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
             P +I GN+  + VYF YP+R    +L G N+    GQTVALVG SGCGKSTT+QL++R
Sbjct: 382  KPDSIMGNLEFKNVYFNYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRL 441

Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
            YD + G V ID  DIR ++V++LR+ I +V QEP LF  TI ENI YG EN+T D++EKA
Sbjct: 442  YDPIEGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKA 501

Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
               AN + F+M LP  ++T VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDT
Sbjct: 502  VKEANAYDFIMKLPHKFNTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 561

Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
            ESE +VQ ALDKAR GRT +VIAHRLST++NAD I     G  +E+G H+ L+  +G+Y+
Sbjct: 562  ESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIYF 621

Query: 2615 RLVEKQS 2635
            +LV  Q+
Sbjct: 622  KLVMTQT 628


>gi|25453402|ref|NP_596892.1| ATP-binding cassette, sub-family B
            (MDR/TAP), member 1A; multiple drug resistant 1a [Rattus
            norvegicus]
 gi|34853968|ref|XP_346684.1| hypothetical protein XP_346683 [Rattus
            norvegicus]
 gi|7739773|gb|AAF69007.1| multidrug resistance protein 1a [Rattus
            norvegicus]
          Length = 1272

 Score =  665 bits (1715), Expect = 0.0
 Identities = 375/888 (42%), Positives = 545/888 (61%), Gaps = 10/888 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            +++ILKG++ +V  G+TVALVG+SGCGKST++ LL R Y+   G + +DG  I+  N+R+
Sbjct: 398  DVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIRTINVRY 457

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  IG+V QEP++F  T+AENIR G   +T  +IE+A K ANA++FI KL  ++DT++G
Sbjct: 458  LREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVG 517

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA EGRTT+ I
Sbjct: 518  ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVI 577

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ----EIERAXXXXXX 709
            AHRLST+RNA  I  FD G+I E+G HDEL+ ++ GIY  +V  Q    EIE
Sbjct: 578  AHRLSTVRNADVIAGFDGGVIVEQGNHDELM-REKGIYFKLVMTQTAGNEIELGNEACES 636

Query: 710  XXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXX 889
                          D+V    +      + R STR  +S+     Q
Sbjct: 637  KDGI----------DNVDMSSKDSGSSLIRRRSTR--KSIRGPHDQ----DGELSTKEAL 680

Query: 890  XXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSI 1069
                  AS + I K  S E    ++ +   +I G   PAFSI++ ++  + +   D   I
Sbjct: 681  DDDVPPASFWRILKLNSTEWPYFVVGVFCAIINGGLQPAFSIIFSKVVGVFTKN-DTPEI 739

Query: 1070 K---ALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDS 1240
            +   + L SL F++L     I+  + G   GKAGE ++ RLR  VF+++++QD S+FDD
Sbjct: 740  QRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDP 799

Query: 1241 RHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXX 1420
            ++  G+LT+RLA DA  V+ A   RLA +   I +L  G+ ++  YGW +  +
Sbjct: 800  KNTTGALTTRLANDAAQVKGATGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPI 859

Query: 1421 XXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSP 1600
                       L  +  +D      + ++ TE+I N++TV +LT+++     +  + + P
Sbjct: 860  IAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIP 919

Query: 1601 HRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMS 1780
            +R A+ +     ++F+   + + +++A  + FG +L++    T   V  V  A+   +M+
Sbjct: 920  YRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGAMA 979

Query: 1781 VMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFAYPNR 1957
            V   +S+ P+Y +A++SA  +  +I +   ID+    G  P  ++GN+   GV F YP R
Sbjct: 980  VGQVSSFAPDYAKAKVSASHIIRIIEKIPEIDSYSTEGLKPNMLEGNVKFNGVMFNYPTR 1039

Query: 1958 RRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVK 2137
                VL G ++    GQT+ALVG SGCGKST +QL+ER+YD + G+V +D  +I+ L+V+
Sbjct: 1040 PNIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEIKQLNVQ 1099

Query: 2138 HLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYDT 2311
             LR ++ +V QEP LF+ +I ENI YG  +  ++ +++ KAA  ANIH F+  LP+ Y+T
Sbjct: 1100 WLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIVKAAKEANIHQFIDSLPEKYNT 1159

Query: 2312 SVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTC 2491
             VG  G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GRTC
Sbjct: 1160 RVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTC 1219

Query: 2492 VVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            +VIAHRLSTIQNAD I+V +NG+  E GTHQ LLA++G+Y+ +V  Q+
Sbjct: 1220 IVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMVSVQA 1267



 Score =  346 bits (888), Expect = 1e-93
 Identities = 211/592 (35%), Positives = 323/592 (53%), Gaps = 16/592 (2%)
 Frame = +2

Query: 911  SLFDIFKYASPEMR-NIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIK----- 1072
            S+  +F+YA    R  +++  +  +I G   P   +V+G +    +  G++ S+
Sbjct: 34   SVLTMFRYAGWLDRFYMLLGTLAAIIHGIALPLMMLVFGDMTDSFANVGNNRSMSFYNAT 93

Query: 1073 ----ALLNSLWFILLAFTG-GISTLISG----SLLGKAGETMSGRLRMDVFRNIMQQDAS 1225
                 L + +      +TG G   LI      SL   A      ++R   F  IM Q+
Sbjct: 94   DIYAKLEDEMTTYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIG 153

Query: 1226 YFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGX 1405
            +FD   H+VG L +RL  D   +   I  ++      + + F G  + F  GW +  +
Sbjct: 154  WFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVIL 211

Query: 1406 XXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTA 1585
                            L     +++ +  +A  +  E ++  +TV A   Q+   + +
Sbjct: 212  AISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNN 271

Query: 1586 ASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALN 1765
              +   R  I + +  ++S   A   +  ++A+A+ +G  L+ +   T   V  V  ++
Sbjct: 272  NLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYTIGQVLTVFFSVL 331

Query: 1766 MASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYF 1942
            + + SV  A+     +  AR +A  +F++I  K  ID+   +G  P  I+GN+  + ++F
Sbjct: 332  IGAFSVGQASPNIEAFANARGAAYEVFSIIDNKPSIDSFSKSGHKPDNIQGNLEFKNIHF 391

Query: 1943 AYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIR 2122
            +YP+R+   +L G N+    GQTVALVG SGCGKSTT+QL++R YD + G V ID  DIR
Sbjct: 392  SYPSRKDVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIR 451

Query: 2123 DLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDG 2302
             ++V++LR+ I +V QEP LF  TI ENI YG EN+T D++EKA   AN + F+M LP
Sbjct: 452  TINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHK 511

Query: 2303 YDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLG 2482
            +DT VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +VQ ALDKAR G
Sbjct: 512  FDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREG 571

Query: 2483 RTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
            RT +VIAHRLST++NAD I     G  +E+G H  L+  +G+Y++LV  Q++
Sbjct: 572  RTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTA 623


>gi|46394986|gb|AAS91649.1| multidrug resistance protein 1a;
            P-glycoprotein [Rattus norvegicus]
          Length = 1272

 Score =  665 bits (1715), Expect = 0.0
 Identities = 375/888 (42%), Positives = 545/888 (61%), Gaps = 10/888 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            +++ILKG++ +V  G+TVALVG+SGCGKST++ LL R Y+   G + +DG  I+  N+R+
Sbjct: 398  DVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIRTINVRY 457

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  IG+V QEP++F  T+AENIR G   +T  +IE+A K ANA++FI KL  ++DT++G
Sbjct: 458  LREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVG 517

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA EGRTT+ I
Sbjct: 518  ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVI 577

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ----EIERAXXXXXX 709
            AHRLST+RNA  I  FD G+I E+G HDEL+ ++ GIY  +V  Q    EIE
Sbjct: 578  AHRLSTVRNADVIAGFDGGVIVEQGNHDELM-REKGIYFKLVMTQTAGNEIELGNEACES 636

Query: 710  XXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXX 889
                          D+V    +      + R STR  +S+     Q
Sbjct: 637  KDGI----------DNVDMSSKDSGSSLIRRRSTR--KSIRGPHDQ----DGELSTKEAL 680

Query: 890  XXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSI 1069
                  AS + I K  S E    ++ +   +I G   PAFSI++ ++  + +   D   I
Sbjct: 681  DDDVPPASFWRILKLNSTEWPYFVVGVFCAIINGGLQPAFSIIFSKVVGVFTKN-DTPEI 739

Query: 1070 K---ALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDS 1240
            +   + L SL F++L     I+  + G   GKAGE ++ RLR  VF+++++QD S+FDD
Sbjct: 740  QRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDP 799

Query: 1241 RHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXX 1420
            ++  G+LT+RLA DA  V+ A   RLA +   I +L  G+ ++  YGW +  +
Sbjct: 800  KNTTGALTTRLANDAAQVKGATGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPI 859

Query: 1421 XXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSP 1600
                       L  +  +D      + ++ TE+I N++TV +LT+++     +  + + P
Sbjct: 860  IAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIP 919

Query: 1601 HRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMS 1780
            +R A+ +     ++F+   + + +++A  + FG +L++    T   V  V  A+   +M+
Sbjct: 920  YRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGAMA 979

Query: 1781 VMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFAYPNR 1957
            V   +S+ P+Y +A++SA  +  +I +   ID+    G  P  ++GN+   GV F YP R
Sbjct: 980  VGQVSSFAPDYAKAKVSASHIIRIIEKIPEIDSYSTEGLKPNMLEGNVKFNGVMFNYPTR 1039

Query: 1958 RRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVK 2137
                VL G ++    GQT+ALVG SGCGKST +QL+ER+YD + G+V +D  +I+ L+V+
Sbjct: 1040 PNIPVLQGLSLEGKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEIKQLNVQ 1099

Query: 2138 HLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYDT 2311
             LR ++ +V QEP LF+ +I ENI YG  +  ++ +++ KAA  ANIH F+  LP+ Y+T
Sbjct: 1100 WLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIVKAAKEANIHQFIDSLPEKYNT 1159

Query: 2312 SVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTC 2491
             VG  G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR GRTC
Sbjct: 1160 RVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTC 1219

Query: 2492 VVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            +VIAHRLSTIQNAD I+V +NG+  E GTHQ LLA++G+Y+ +V  Q+
Sbjct: 1220 IVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMVSVQA 1267



 Score =  347 bits (889), Expect = 1e-93
 Identities = 211/592 (35%), Positives = 323/592 (53%), Gaps = 16/592 (2%)
 Frame = +2

Query: 911  SLFDIFKYASPEMR-NIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIK----- 1072
            S+  +F+YA    R  +++  +  +I G   P   +V+G +    +  G++ S+
Sbjct: 34   SVLTMFRYAGWLDRFYMLLGTLAAIIHGIALPLMMLVFGDMTDSFANVGNNRSMSFYNAT 93

Query: 1073 ----ALLNSLWFILLAFTG-GISTLISG----SLLGKAGETMSGRLRMDVFRNIMQQDAS 1225
                 L + +      +TG G   LI      SL   A      ++R   F  IM Q+
Sbjct: 94   DIYAKLKDEMTTYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIG 153

Query: 1226 YFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGX 1405
            +FD   H+VG L +RL  D   +   I  ++      + + F G  + F  GW +  +
Sbjct: 154  WFDV--HDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVIL 211

Query: 1406 XXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTA 1585
                            L     +++ +  +A  +  E ++  +TV A   Q+   + +
Sbjct: 212  AISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNN 271

Query: 1586 ASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALN 1765
              +   R  I + +  ++S   A   +  ++A+A+ +G  L+ +   T   V  V  ++
Sbjct: 272  NLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYTIGQVLTVFFSVL 331

Query: 1766 MASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYF 1942
            + + SV  A+     +  AR +A  +F++I  K  ID+   +G  P  I+GN+  + ++F
Sbjct: 332  IGAFSVGQASPNIEAFANARGAAYEVFSIIDNKPSIDSFSKSGHKPDNIQGNLEFKNIHF 391

Query: 1943 AYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIR 2122
            +YP+R+   +L G N+    GQTVALVG SGCGKSTT+QL++R YD + G V ID  DIR
Sbjct: 392  SYPSRKDVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIR 451

Query: 2123 DLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDG 2302
             ++V++LR+ I +V QEP LF  TI ENI YG EN+T D++EKA   AN + F+M LP
Sbjct: 452  TINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHK 511

Query: 2303 YDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLG 2482
            +DT VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +VQ ALDKAR G
Sbjct: 512  FDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREG 571

Query: 2483 RTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
            RT +VIAHRLST++NAD I     G  +E+G H  L+  +G+Y++LV  Q++
Sbjct: 572  RTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTA 623


>gi|7511698|pir||T31073 multidrug resistance p-glycoprotein - nematode
            (Haemonchus contortus)
 gi|3057042|gb|AAC38987.1| P-glycoprotein [Haemonchus contortus]
          Length = 1275

 Score =  664 bits (1714), Expect = 0.0
 Identities = 367/880 (41%), Positives = 537/880 (60%), Gaps = 4/880 (0%)
 Frame = +2

Query: 5    LKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWL 184
            L+ILKGVS +V+ G+ +ALVG SGCGKST++ LL+RFY+   G + +D I + + N++ L
Sbjct: 408  LQILKGVSLQVSAGQKIALVGSSGCGKSTNVNLLLRFYDPTRGKVTIDDIDVCDLNVQKL 467

Query: 185  RSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIGA 364
            R  IG+V QEP++F  T+ ENI+MG    T ++++EAC++ANA +F  +L + Y T +G
Sbjct: 468  REQIGVVSQEPVLFDGTLFENIKMGYEQATMEEVQEACRVANAADFTKRLPEGYGTRVGE 527

Query: 365  GAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIA 544
              VQLSGGQKQR+AIARAI++ P+ILLLDEATSALDTE+E +VQ AL+KA +GRTT+ +A
Sbjct: 528  RGVQLSGGQKQRIAIARAIIKNPRILLLDEATSALDTEAESIVQEALEKAQKGRTTVIVA 587

Query: 545  HRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXXX 724
            HRLSTIRN  +I VF  G I E+GTH EL++K  G++  M +AQ + +
Sbjct: 588  HRLSTIRNVDQIFVFKNGTIVEQGTHAELMNKR-GVFFEMTQAQVLRQEKEEEVLDSDAE 646

Query: 725  XXXHRSFHRDSVTSDEERELQQSLA--RDSTRLRQSMISTTTQVPXXXXXXXXXXXXXXG 898
                     D V+ D       SL   ++STR   S + +   +
Sbjct: 647  S--------DVVSPDIALPHLSSLRSRKESTRSAISAVPSVRSMQIEMEDLR-------- 690

Query: 899  AMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKAL 1078
            A    +  IF +   +    I+ L+  +I G   P F+++Y Q+ ++ S   D +    L
Sbjct: 691  AKPTPMSKIFYFNRDKWGYFILGLIACIITGTVTPTFAVLYAQIIQVYSEPVDQMKGHVL 750

Query: 1079 LNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGS 1258
                 FI++      +   S   LG+ GE ++ +LR + F+N+++Q+  ++DD RH  G
Sbjct: 751  FWCGAFIVIGLVHAFAFFFSAICLGRCGEALTKKLRFEAFKNLLRQNVGFYDDIRHGTGK 810

Query: 1259 LTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXX 1438
            L +R ATDAPNV+     RL  VL+ +V++   + + F +GW +A I
Sbjct: 811  LCTRFATDAPNVRYVFT-RLPGVLSSVVTIIGALVIGFIFGWQLALILMVMVPLIIGSGY 869

Query: 1439 XXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIV 1618
                    +  RD +   EA ++ ++++ N +TV AL +QE  +  +    K P+R  +
Sbjct: 870  FEMRMQFGKKMRDTELLEEAGKVASQAVENIRTVHALNRQEQFHFMYCEYLKEPYRENLC 929

Query: 1619 RGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAAS 1798
            +       FA + S + + +A+A+  G   + N+   P  V++V  A       V   +S
Sbjct: 930  QAHTYGGVFAFSQSLLFFMYAVAFWIGAIFVDNHSMQPIDVYRVFFAFMFCGQMVGNISS 989

Query: 1799 YFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVLD 1978
            + P+ V+AR++A ++F +I   S IDN    G T  I G+I+ R VYF YP RR+  VL
Sbjct: 990  FIPDVVKARLAASLLFYLIEHPSEIDNLSEDGVTKKISGHISFRNVYFNYPTRRQIRVLR 1049

Query: 1979 GFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIA 2158
            G N+  N G TVALVG SGCGKST + L+ER+Y+   G + +D  +IR++++++LR+ +
Sbjct: 1050 GLNLEINPGTTVALVGQSGCGKSTVMALLERFYNQNKGVITVDGENIRNMNIRNLREQVC 1109

Query: 2159 LVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGG 2332
            +V QEPTLF+ TI ENI YGL++   + +QV  AA +ANIH FV+GLP+GYDT VG  G
Sbjct: 1110 IVSQEPTLFDCTIMENICYGLDDPKPSYEQVVAAAKMANIHNFVLGLPEGYDTRVGEKGT 1169

Query: 2333 RLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRL 2512
            +LSGGQKQR+AIARA++RDP ILLLDEATSALDTESEKIVQ+AL+ AR GRTC+VIAHRL
Sbjct: 1170 QLSGGQKQRIAIARALIRDPPILLLDEATSALDTESEKIVQDALEVARQGRTCLVIAHRL 1229

Query: 2513 STIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
            STIQ++D I++ + GKA + GTH+ LL +  LY RL E Q
Sbjct: 1230 STIQDSDVIVMIQEGKATDRGTHEHLLMKNDLYKRLCETQ 1269



 Score =  313 bits (803), Expect = 1e-83
 Identities = 182/517 (35%), Positives = 291/517 (56%), Gaps = 2/517 (0%)
 Frame = +2

Query: 1088 LWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSLTS 1267
            L+++ L F    ++ I         E ++ +LR    + I++Q  S+FD  +   G+LT+
Sbjct: 116  LYYLGLGFAMFATSYIQIVCWETFAERITHKLRKIYLKAILRQQISWFDIQQ--TGNLTA 173

Query: 1268 RLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXXXXX 1447
            RL  D   V+  +  +L+  +  + +   G  V F Y W+M  +
Sbjct: 174  RLTDDLERVREGLGDKLSLFIQMVSAFVAGFCVGFAYSWSMTLVMMVVAPFIVISANWMS 233

Query: 1448 XYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVRGL 1627
              +  R Q + ++   A  +  E+ S+ +TV ++   +     F AA +   +  +V+
Sbjct: 234  KIVATRTQVEQETYAVAGAIAEETFSSIRTVHSICGHKRELTRFEAALEKGRQTGLVKYF 293

Query: 1628 WQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPY-TVFQVIEALNMASMSVMLAASYF 1804
            +  +           ++A+A+ +G  LI N+ +     +F V  A+   S ++     +
Sbjct: 294  YMGVGVGFGQMCTYVSYALAFWYGSVLIINDPALDRGRIFTVFFAVMSGSAALGTCLPHL 353

Query: 1805 PEYVRARISAGIMFTMIRQKSVIDNRGLTGDT-PTIKGNINMRGVYFAYPNRRRQLVLDG 1981
                 AR +   + ++I  +  ID   L G     ++G+I  + V+F+YP+RR   +L G
Sbjct: 354  NTISIARGAVRSVLSVINSRPKIDPYSLDGIVLNNMRGSIRFKNVHFSYPSRRTLQILKG 413

Query: 1982 FNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIAL 2161
             ++  + GQ +ALVG SGCGKST + L+ R+YD   G V IDD D+ DL+V+ LR+ I +
Sbjct: 414  VSLQVSAGQKIALVGSSGCGKSTNVNLLLRFYDPTRGKVTIDDIDVCDLNVQKLREQIGV 473

Query: 2162 VGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRLS 2341
            V QEP LF+ T+ ENI  G E  T ++V++A  +AN   F   LP+GY T VG  G +LS
Sbjct: 474  VSQEPVLFDGTLFENIKMGYEQATMEEVQEACRVANAADFTKRLPEGYGTRVGERGVQLS 533

Query: 2342 GGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTI 2521
            GGQKQR+AIARAI+++P+ILLLDEATSALDTE+E IVQEAL+KA+ GRT V++AHRLSTI
Sbjct: 534  GGQKQRIAIARAIIKNPRILLLDEATSALDTEAESIVQEALEKAQKGRTTVIVAHRLSTI 593

Query: 2522 QNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
            +N D+I V +NG  +E+GTH  L+ +RG+++ + + Q
Sbjct: 594  RNVDQIFVFKNGTIVEQGTHAELMNKRGVFFEMTQAQ 630



 Score =  229 bits (584), Expect = 3e-58
 Identities = 120/229 (52%), Positives = 162/229 (70%), Gaps = 2/229 (0%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            ++++L+G++ E+NPG TVALVG SGCGKST + LL RFYNQ  G+I +DG  I+  NIR
Sbjct: 1044 QIRVLRGLNLEINPGTTVALVGQSGCGKSTVMALLERFYNQNKGVITVDGENIRNMNIRN 1103

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMG--DVLITDQDIEEACKMANAHEFICKLSDRYDTV 355
            LR  + IV QEP +F  T+ ENI  G  D   + + +  A KMAN H F+  L + YDT
Sbjct: 1104 LREQVCIVSQEPTLFDCTIMENICYGLDDPKPSYEQVVAAAKMANIHNFVLGLPEGYDTR 1163

Query: 356  IGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTL 535
            +G    QLSGGQKQR+AIARA++R P ILLLDEATSALDTESE++VQ AL+ A +GRT L
Sbjct: 1164 VGEKGTQLSGGQKQRIAIARALIRDPPILLLDEATSALDTESEKIVQDALEVARQGRTCL 1223

Query: 536  CIAHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEI 682
             IAHRLSTI+++  I++  +G   +RGTH+ L+ K+D +Y  + + Q +
Sbjct: 1224 VIAHRLSTIQDSDVIVMIQEGKATDRGTHEHLLMKND-LYKRLCETQRL 1271


>gi|48267183|gb|AAQ63650.3| multi-drug resistance P-glycoprotein 1;
            PGY1; MDR1; GP170; ABC20; P-GP [Oryctolagus cuniculus]
          Length = 1279

 Score =  664 bits (1714), Expect = 0.0
 Identities = 368/886 (41%), Positives = 543/886 (60%), Gaps = 8/886 (0%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            E+KILKG++ +V  G+TVALVG+SGCGKST++ L+ R Y+   G++ +DG  I+  N+R+
Sbjct: 404  EVKILKGLNLKVESGQTVALVGNSGCGKSTTVQLMRRLYDPTDGVVSIDGQDIRTMNVRY 463

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR   G+V QEP++F  T+AEN+R G   +T  +IE+A K ANA+ FI KL  ++DT++G
Sbjct: 464  LREITGVVSQEPVLFATTIAENVRYGREDVTMDEIEKAVKEANAYNFIMKLPHKFDTLVG 523

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA +GRTT+ I
Sbjct: 524  ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVI 583

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
            AHRLST+RNA  I  FD G+I ERG H+EL+ +  G+Y  +V  Q
Sbjct: 584  AHRLSTVRNADVIAGFDNGVIVERGNHEELM-RQKGVYFRLVTMQTAGNEIDLENSA--- 639

Query: 722  XXXXHRSFHRDSVTSDEERELQQSLARDSTRL---RQSMISTTTQVPXXXXXXXXXXXXX 892
                       S +  E+ +L +  A++S      R+S   +
Sbjct: 640  -----------SESRGEKMDLVEMSAKESGSSLIRRRSSHKSFHGAQGQDGKLSTTEAQN 688

Query: 893  XGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIK 1072
                  S + I K    E    ++ ++  +I G   PAF++V+ ++  + +   DD + +
Sbjct: 689  ENVPPVSFWRIMKLNLTEWPYFLVGVICAIINGGLQPAFAVVFSKIVGVFTRNDDDETKR 748

Query: 1073 --ALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRH 1246
              + L SL F++L     I+  + G   GKAGE ++ RLR  VF+++++QD S+FDD ++
Sbjct: 749  RNSDLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKN 808

Query: 1247 NVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXX 1426
              G+LT+RLA DA  V+ A   RLA +   I +L  G+ ++  YGW +  +
Sbjct: 809  TTGALTTRLANDAAQVKGATGSRLAVIAQNIANLGTGIIISLVYGWQLTLLLLAIVPIIA 868

Query: 1427 XXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHR 1606
                     L  +  +D      + ++ TE+I N++TV +LT+++   + +  + + P+R
Sbjct: 869  IAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFENMYAQSLQVPYR 928

Query: 1607 RAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVM 1786
             ++ +     ++F+   + + +++A  + FG +L++    +   V  V  A+   +M+V
Sbjct: 929  NSLEKAHIFGITFSFTQAMMYFSYAGCFRFGAFLVARELMSFENVLLVFSAVVFGAMAVG 988

Query: 1787 LAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYPNRRR 1963
              +S+ P+Y +A+ISA  +  ++ +   ID+    G  P T++GN+  + V F YP R
Sbjct: 989  QVSSFAPDYAKAKISASHIIMILEKLPKIDSYSTEGLKPGTLEGNMTFKDVVFNYPTRPD 1048

Query: 1964 QLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHL 2143
              VL G N+    GQT+ALVGPSGCGKST +QLIER+YD L G+V +D  ++  L+V+ L
Sbjct: 1049 IPVLQGLNLQVKKGQTLALVGPSGCGKSTVVQLIERFYDPLAGTVLLDGKEVNQLNVQWL 1108

Query: 2144 RDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYDTSV 2317
            R ++ +V QEP LF+ +I ENI YG  +  ++QD++ KAA  ANIH F+  LPD Y+T V
Sbjct: 1109 RAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIIKAAKEANIHAFIDSLPDKYNTRV 1168

Query: 2318 GASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVV 2497
            G  G +LSGGQKQR+AIARA+VR P ILLLDEATSA DTESEK+VQEALDKAR GRTCVV
Sbjct: 1169 GDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSAPDTESEKVVQEALDKAREGRTCVV 1228

Query: 2498 IAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            IAHRLSTIQNAD I+V +NG+  E GTH  LLA++G+Y+ +V  Q+
Sbjct: 1229 IAHRLSTIQNADMIVVFQNGRVKECGTHHQLLAQKGIYFSMVSVQA 1274



 Score =  332 bits (852), Expect = 2e-89
 Identities = 205/599 (34%), Positives = 320/599 (53%), Gaps = 23/599 (3%)
 Frame = +2

Query: 911  SLFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGD---------- 1057
            S F +F+Y++  +   +++  +  +I G   P   +V+G +    S  G+
Sbjct: 33   SAFAMFRYSNWLDKLYMVVGTLAAIIHGAALPLMMLVFGDMTDSFSNPGNMIPANITNLN 92

Query: 1058 --DVSIKALLNSLWFILLAFTGGISTLISGSLLGK---------AGETMSGRLRMDVFRN 1204
              ++S   +   L   +  +    S + +G L+           A    + ++R   F +
Sbjct: 93   MSNISASEIYEHLEEEMTTYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQTFKIRKQFFHS 152

Query: 1205 IMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGW 1384
            IM+Q+  +FD   H+VG L +RL  D   +   I  ++      + + F G  V F  GW
Sbjct: 153  IMRQEIGWFDV--HDVGELNTRLTDDVSKINDGIGDKIGMFFQSMSTFFTGFIVGFTRGW 210

Query: 1385 NMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEY 1564
             +  +                  +     +++ +  +A  +  E ++  +TV A   Q+
Sbjct: 211  KLTLVILAISPVLGLSAALWAKIMSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQQK 270

Query: 1565 MYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVF 1744
              + +    +   R  I + +  ++S  +A   +  ++A+A+ +   L      +   V
Sbjct: 271  ELERYNKNLEEAKRIGIKKAITANISVGVAFLLMYASYALAFWYWNHLGHLKEYSIGQVL 330

Query: 1745 QVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNI 1921
             V  ++ + + S+  A+     +  AR +A  +F +I     ID+    G  P  IKGN+
Sbjct: 331  TVFFSVLVGAFSIGQASPNVEAFANARGAAYEIFRIIDNMPSIDSYSEAGHKPDNIKGNL 390

Query: 1922 NMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVK 2101
              R V+F+YP+R+   +L G N+    GQTVALVG SGCGKSTT+QL+ R YD   G V
Sbjct: 391  EFRNVHFSYPSRKEVKILKGLNLKVESGQTVALVGNSGCGKSTTVQLMRRLYDPTDGVVS 450

Query: 2102 IDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTF 2281
            ID  DIR ++V++LR+   +V QEP LF  TI EN+ YG E++T D++EKA   AN + F
Sbjct: 451  IDGQDIRTMNVRYLREITGVVSQEPVLFATTIAENVRYGREDVTMDEIEKAVKEANAYNF 510

Query: 2282 VMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEA 2461
            +M LP  +DT VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +VQ A
Sbjct: 511  IMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVA 570

Query: 2462 LDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS 2638
            LDKAR GRT +VIAHRLST++NAD I    NG  +E G H+ L+ ++G+Y+RLV  Q++
Sbjct: 571  LDKARKGRTTIVIAHRLSTVRNADVIAGFDNGVIVERGNHEELMRQKGVYFRLVTMQTA 629


>gi|50732589|ref|XP_418707.1| PREDICTED: similar to ATP-binding
            cassette, sub-family B (MDR/TAP), member 1A; multiple
            drug resistant 1a [Gallus gallus]
          Length = 1734

 Score =  659 bits (1700), Expect = 0.0
 Identities = 369/885 (41%), Positives = 531/885 (59%), Gaps = 12/885 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            ++ ILKG++ +V  G+T+ALVG SGCGKST++ LL RFY+   G + LDG  I+  N++W
Sbjct: 483  DITILKGLNLKVQTGKTIALVGASGCGKSTTVQLLQRFYDPDQGEVTLDGRDIRTLNVKW 542

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  IGIV QEP++F  T+AENIR G   I+D +IE+A K ANA +FI +L D+++T++G
Sbjct: 543  LRENIGIVSQEPVLFATTIAENIRYGREDISDAEIEQAAKEANAFDFISRLPDKFNTMVG 602

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                QLSGGQKQR+AIARA+ R P+ILLLDEATSALDT+SE +VQ ALDKA  GRTT+ I
Sbjct: 603  ERGAQLSGGQKQRIAIARALARNPKILLLDEATSALDTQSESVVQAALDKARTGRTTIVI 662

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
            AHRLSTIR A  I  F++G++ E+GTH EL+ +  G+Y S+V  Q
Sbjct: 663  AHRLSTIRTADTIAAFEKGIVVEQGTHSELMLQK-GVYYSLVMQQSGSNNVQDDGTSEED 721

Query: 722  XXXXHRSFHRDSVTSDEER-------ELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXX 880
                   +  +  +S  E+       E      R S R R S   +
Sbjct: 722  EETEAEEYEENDKSSSVEKLNLKDHFEEPVITGRGSIRRRSSRYKSKRSSSKKKSSKKKK 781

Query: 881  XXXXXGAMEASLFD-IFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGD 1057
                   + A  +  I     PE   +++ ++   + G   PAF++++G++
Sbjct: 782  KELEEENLPAVPYTRILALNKPEWLYVLLGVIAAAVSGGVHPAFAVIFGKIIGAFQERDP 841

Query: 1058 DVSIK-ALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFD 1234
            +   K  L+ SL F+LL      + +I G + GK+GE ++ RLR   F+ ++QQ+  ++D
Sbjct: 842  ERRNKNTLVLSLMFLLLGVITLATYIIQGFMFGKSGEILTMRLRSLSFKALLQQEIGWYD 901

Query: 1235 DSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXX 1414
            D ++ VG L +RLATDA  V+ A   RL  +   + +L   + +AF YGW +  +
Sbjct: 902  DQKNAVGVLLTRLATDASQVKGATGSRLGLMTMTVFTLLTAIIIAFVYGWQLTLLILACI 961

Query: 1415 XXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASK 1594
                         +     +D  +  EA R+ TES+ N +TV +LT++E  Y+ +  +
Sbjct: 962  PFVIAANAANVSSVSGHAAKDQKALEEAGRVSTESVENIRTVASLTREEAFYEKYINSLN 1021

Query: 1595 SPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMAS 1774
             P+R ++ +      ++ +A S   +  A  + FG WLI+   +    VF V  ++  A+
Sbjct: 1022 GPYRDSLKKAPLYGFTYGIAQSANYFVNAAVFRFGAWLIARCLTNFENVFIVFSSVIFAA 1081

Query: 1775 MSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDT-PTIKGNINMRGVYFAYP 1951
            M+V  +AS  P+Y +A++SA  +F ++ +K  ID+    G+     +GNI  R ++F YP
Sbjct: 1082 MNVGQSASLAPDYGKAKVSAQRIFHLLDRKPQIDSYSEEGEKLSNFEGNIEFRNIHFVYP 1141

Query: 1952 NRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLS 2131
             R    VL G N+  N GQT+ALVG SGCGKST+IQL+ER+YD + G V  D  D + L
Sbjct: 1142 TRPEVQVLQGLNVKVNKGQTLALVGSSGCGKSTSIQLLERFYDPVEGQVLADGFDTKSLH 1201

Query: 2132 VKHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGY 2305
            ++ LR  + LV QEP LF+ +I ENI YG  N  ++Q+++E+AA  ANIH F+  LP+ Y
Sbjct: 1202 LQWLRSRLGLVSQEPILFDCSIAENIQYGDNNRLVSQEEIEEAAKAANIHAFIDKLPEKY 1261

Query: 2306 DTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGR 2485
            +T VG  G +LSGGQKQR+AIARA+VR+P +LLLDEATSALDTESEKIVQ+ALD AR GR
Sbjct: 1262 NTRVGEKGTQLSGGQKQRIAIARALVRNPAVLLLDEATSALDTESEKIVQKALDNARQGR 1321

Query: 2486 TCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRL 2620
            TC+VIAHRL+TIQNAD I V +NG+ +E+GTH  LLA+ G YY L
Sbjct: 1322 TCIVIAHRLTTIQNADIIAVIQNGRVVEQGTHSQLLAKEGHYYAL 1366



 Score =  326 bits (836), Expect = 2e-87
 Identities = 197/600 (32%), Positives = 317/600 (52%), Gaps = 26/600 (4%)
 Frame = +2

Query: 914  LFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFK--ILSAGGDDVSIKALLN 1084
            + ++F+YA   ++  +++ L+     G   P   I++G +    +LS      S  A +N
Sbjct: 111  VIELFRYADWVDILLMVVGLIAAAANGTGLPLMIIIFGDMTNAFVLSGVNSSTSEGASVN 170

Query: 1085 S-------------------LWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNI 1207
            +                    +++ + F   I + I       A    + R+R   F  +
Sbjct: 171  NSSCQPAPGVDIEADMTKFAYYYVGIGFAVLILSTIQVWTFLIAATRQTSRIRRKFFFAV 230

Query: 1208 MQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWN 1387
            + Q+ ++FD ++  +G+L +RL  D   +   I  ++   +    +   G+ + F +GW
Sbjct: 231  LHQEMAWFDSTQ--IGTLNTRLTDDINTIHEGIGDKICIFVQFFSTFLAGITIGFAHGWK 288

Query: 1388 MAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYM 1567
            +  +                  L     +++ +  +A  +  E ++  +TV A   Q+
Sbjct: 289  LTLVILSVSPLLAASAAVWSTLLASLTAKELSAYAKAGAVAEEVLTAIRTVVAFNGQQKA 348

Query: 1568 YDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLI---SNNWSTPYT 1738
               +    ++     + + +  + S  ++   +  ++A+A+ +G  L      N+
Sbjct: 349  LAKYDTNLEAARHVGVKKSITTNTSLGVSQFLIFGSYALAFWYGTKLTVEEPENYDIGRV 408

Query: 1739 VFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKG 1915
            +      L + + S+  AA        AR +A  ++ +I +K +ID+    G  P  +KG
Sbjct: 409  LIVFFSVL-IGAFSLGQAAPNLESVANARGAAYEVYQIINKKRLIDSSSKEGYKPDKLKG 467

Query: 1916 NINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGS 2095
             I  R ++F+YP+R    +L G N+    G+T+ALVG SGCGKSTT+QL++R+YD   G
Sbjct: 468  EIEFRNIHFSYPSRPDITILKGLNLKVQTGKTIALVGASGCGKSTTVQLLQRFYDPDQGE 527

Query: 2096 VKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIH 2275
            V +D  DIR L+VK LR+NI +V QEP LF  TI ENI YG E+I+  ++E+AA  AN
Sbjct: 528  VTLDGRDIRTLNVKWLRENIGIVSQEPVLFATTIAENIRYGREDISDAEIEQAAKEANAF 587

Query: 2276 TFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQ 2455
             F+  LPD ++T VG  G +LSGGQKQR+AIARA+ R+PKILLLDEATSALDT+SE +VQ
Sbjct: 588  DFISRLPDKFNTMVGERGAQLSGGQKQRIAIARALARNPKILLLDEATSALDTQSESVVQ 647

Query: 2456 EALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
             ALDKAR GRT +VIAHRLSTI+ AD I     G  +E+GTH  L+ ++G+YY LV +QS
Sbjct: 648  AALDKARTGRTTIVIAHRLSTIRTADTIAAFEKGIVVEQGTHSELMLQKGVYYSLVMQQS 707


>gi|6679297|ref|NP_032856.1| ATP-binding cassette, sub-family B
            (MDR/TAP), member 4; P glycoprotein 2 [Mus musculus]
 gi|126929|sp|P21440|MDR2_MOUSE Multidrug resistance protein 2
            (P-glycoprotein 2)
 gi|72476|pir||DVMS2 multidrug resistance protein 2 - mouse
 gi|387428|gb|AAA39516.1| multidrug resistance protein
          Length = 1276

 Score =  659 bits (1699), Expect = 0.0
 Identities = 368/881 (41%), Positives = 530/881 (59%), Gaps = 4/881 (0%)
 Frame = +2

Query: 5    LKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWL 184
            +KILKG++ +V  G+TVALVG+SGCGKST++ LL R Y+   G I +DG  I+ +N+R L
Sbjct: 406  IKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGKISIDGQDIRNFNVRCL 465

Query: 185  RSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIGA 364
            R  IG+V QEP++F  T+AENIR G   +T  +IE+A K ANA++FI KL  ++DT++G
Sbjct: 466  REIIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIEKAVKEANAYDFIMKLPQKFDTLVGD 525

Query: 365  GAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIA 544
               QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE  VQ ALDKA EGRTT+ IA
Sbjct: 526  RGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIA 585

Query: 545  HRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXXX 724
            HRLSTIRNA  I  F+ G+I E+G+H EL+ K+ GIY  +V  Q
Sbjct: 586  HRLSTIRNADVIAGFEDGVIVEQGSHSELMKKE-GIYFRLVNMQ--------------TA 630

Query: 725  XXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXXXXGAM 904
                 S   +   SDE+     +      R+ ++    + + P
Sbjct: 631  GSQILSEEFEVELSDEKAAGDVAPNGWKARIFRNSTKKSLKSPHQNRLDEETNELDANVP 690

Query: 905  EASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSI-KALL 1081
              S   + K    E    ++  V  +  G   PAFSI+  ++  I   G D V   K  +
Sbjct: 691  PVSFLKVLKLNKTEWPYFVVGTVCAIANGALQPAFSIILSEMIAIFGPGDDAVKQQKCNM 750

Query: 1082 NSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSL 1261
             SL F+ L      +  + G   GKAGE ++ RLR   F+ +++QD S+FDD +++ G+L
Sbjct: 751  FSLVFLGLGVLSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDHKNSTGAL 810

Query: 1262 TSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXXX 1441
            ++RLATDA  VQ A   +LA +     +L  G+ ++F YGW +  +
Sbjct: 811  STRLATDAAQVQGATGTKLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVAGIV 870

Query: 1442 XXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVR 1621
                L    +RD      A ++ TE+I N +TV +LT++      +      P+R ++ +
Sbjct: 871  EMKMLAGNAKRDKKEMEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLHGPYRNSVRK 930

Query: 1622 GLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAASY 1801
                 ++F+++ +F+ +++A  + FG +LI N       V  V  A+ + ++++  A+S+
Sbjct: 931  AHIYGITFSISQAFMYFSYAGCFRFGSYLIVNGHMRFKDVILVFSAIVLGAVALGHASSF 990

Query: 1802 FPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFAYPNRRRQLVLD 1978
             P+Y +A++SA  +F++  ++ +ID+    G  P   +G++    V F YP R    VL
Sbjct: 991  APDYAKAKLSAAYLFSLFERQPLIDSYSGEGLWPDKFEGSVTFNEVVFNYPTRANVPVLQ 1050

Query: 1979 GFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIA 2158
            G ++    GQT+ALVG SGCGKST +QL+ER+YD + GSV +D  + + L+V+ LR  +
Sbjct: 1051 GLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVLLDGQEAKKLNVQWLRAQLG 1110

Query: 2159 LVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGG 2332
            +V QEP LF+ +I ENI YG  +  +  D++ +AA  ANIH F+  LP  Y+T VG  G
Sbjct: 1111 IVSQEPILFDCSIAENIAYGDNSRVVPHDEIVRAAKEANIHPFIETLPQKYNTRVGDKGT 1170

Query: 2333 RLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRL 2512
            +LSGGQKQR+AIARA++R P++LLLDEATSALDTESEK+VQEALDKAR GRTC+VIAHRL
Sbjct: 1171 QLSGGQKQRIAIARALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRL 1230

Query: 2513 STIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            STIQNAD I+V  NGK  E GTHQ LLA++G+Y+ +V  Q+
Sbjct: 1231 STIQNADLIVVIENGKVKEHGTHQQLLAQKGIYFSMVNIQA 1271



 Score =  329 bits (844), Expect = 2e-88
 Identities = 188/488 (38%), Positives = 275/488 (55%), Gaps = 1/488 (0%)
 Frame = +2

Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
            ++R   F  I++Q+  +FD        L +RL  D   +   I  ++      I + F G
Sbjct: 145  KIRQKFFHAILRQEMGWFDIK--GTTELNTRLTDDVSKISEGIGDKVGMFFQAIATFFAG 202

Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
              V F  GW +  +                  L     +++ +  +A  +  E+    +T
Sbjct: 203  FIVGFIRGWKLTLVIMAISPILGLSTAVWAKILSTFSDKELAAYAKAGAVAEEAPGAIRT 262

Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
            V A   Q    + +    ++  +  I + +  ++S  +A   +  ++A+A+ +G  L+ +
Sbjct: 263  VIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVIS 322

Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
               T      V  ++ + + SV  AA     +  AR +A ++F +I     ID+    G
Sbjct: 323  KEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGH 382

Query: 1898 TP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
             P  IKGN+    V+F+YP+R    +L G N+    GQTVALVG SGCGKSTT+QL++R
Sbjct: 383  KPDNIKGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRL 442

Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
            YD   G + ID  DIR+ +V+ LR+ I +V QEP LF+ TI ENI YG  N+T D++EKA
Sbjct: 443  YDPTEGKISIDGQDIRNFNVRCLREIIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIEKA 502

Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
               AN + F+M LP  +DT VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDT
Sbjct: 503  VKEANAYDFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 562

Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
            ESE  VQ ALDKAR GRT +VIAHRLSTI+NAD I    +G  +E+G+H  L+ + G+Y+
Sbjct: 563  ESEAEVQAALDKAREGRTTIVIAHRLSTIRNADVIAGFEDGVIVEQGSHSELMKKEGIYF 622

Query: 2615 RLVEKQSS 2638
            RLV  Q++
Sbjct: 623  RLVNMQTA 630


>gi|4505771|ref|NP_000434.1| ATP-binding cassette, subfamily B, member
            4 isoform A; P glycoprotein 3/multiple drug resistance 3;
            P-glycoprotein-3/multiple drug resistance-3; multiple
            drug resistance 3 [Homo sapiens]
 gi|126932|sp|P21439|MDR3_HUMAN Multidrug resistance protein 3
            (P-glycoprotein 3)
 gi|72473|pir||DVHU3 multidrug resistance protein 3 - human
 gi|307181|gb|AAA36207.1| P-glycoprotein
          Length = 1279

 Score =  658 bits (1698), Expect = 0.0
 Identities = 366/883 (41%), Positives = 533/883 (59%), Gaps = 6/883 (0%)
 Frame = +2

Query: 5    LKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWL 184
            +KILKG++ +V  G+TVALVG SGCGKST++ L+ R Y+   G I +DG  I+ +N+ +L
Sbjct: 409  VKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYL 468

Query: 185  RSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIGA 364
            R  IG+V QEP++F  T+AENI  G   +T  +I++A K ANA+EFI KL  ++DT++G
Sbjct: 469  REIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGE 528

Query: 365  GAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIA 544
               QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE  VQ ALDKA EGRTT+ IA
Sbjct: 529  RGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIA 588

Query: 545  HRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXXX 724
            HRLST+RNA  I  F+ G+I E+G+H EL+ K+ G+Y  +V  Q
Sbjct: 589  HRLSTVRNADVIAGFEDGVIVEQGSHSELMKKE-GVYFKLVNMQ----TSGSQIQSEEFE 643

Query: 725  XXXHRSFHRDSVTSDEERELQQSLARD--STRLRQSMISTTTQVPXXXXXXXXXXXXXXG 898
                ++  R +    + R  + S  ++  ++++ Q  +   T
Sbjct: 644  LNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETD------------GLEAN 691

Query: 899  AMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSI-KA 1075
                S   + K    E    ++  V  +  G   PAFS+++ ++  I   G D V   K
Sbjct: 692  VPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKC 751

Query: 1076 LLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVG 1255
             + SL F+ L      +  + G   GKAGE ++ RLR   F+ +++QD S+FDD +++ G
Sbjct: 752  NIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTG 811

Query: 1256 SLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXX 1435
            +L++RLATDA  VQ A   RLA +   I +L  G+ ++F YGW +  +
Sbjct: 812  ALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSG 871

Query: 1436 XXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAI 1615
                  L    +RD      A ++ TE+I N +TV +LT++      +      P+R ++
Sbjct: 872  IVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSV 931

Query: 1616 VRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAA 1795
             +     ++F+++ +F+ +++A  + FG +LI N       V  V  A+   ++++  A+
Sbjct: 932  QKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHAS 991

Query: 1796 SYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFAYPNRRRQLV 1972
            S+ P+Y +A++SA  +F +  ++ +ID+    G  P   +GNI    V F YP R    V
Sbjct: 992  SFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPV 1051

Query: 1973 LDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDN 2152
            L G ++    GQT+ALVG SGCGKST +QL+ER+YD L G+V +D  + + L+V+ LR
Sbjct: 1052 LQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQ 1111

Query: 2153 IALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYDTSVGAS 2326
            + +V QEP LF+ +I ENI YG  +  ++QD++  AA  ANIH F+  LP  Y+T VG
Sbjct: 1112 LGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDK 1171

Query: 2327 GGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAH 2506
            G +LSGGQKQR+AIARA++R P+ILLLDEATSALDTESEK+VQEALDKAR GRTC+VIAH
Sbjct: 1172 GTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAH 1231

Query: 2507 RLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            RLSTIQNAD I+V +NG+  E GTHQ LLA++G+Y+ +V  Q+
Sbjct: 1232 RLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1274



 Score =  331 bits (849), Expect = 5e-89
 Identities = 186/488 (38%), Positives = 279/488 (57%), Gaps = 1/488 (0%)
 Frame = +2

Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
            ++R   F  I++Q+  +FD +  +   L +RL  D   +   I  ++      + + F G
Sbjct: 148  KIRQKFFHAILRQEIGWFDIN--DTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAG 205

Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
              V F  GW +  +                  L     +++ +  +A  +  E++   +T
Sbjct: 206  FIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRT 265

Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
            V A   Q    + +    ++     I + +  ++S  +A   +  ++A+A+ +G  L+ +
Sbjct: 266  VIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVIS 325

Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
               T      V  ++ + + SV  AA     +  AR +A ++F +I     ID+    G
Sbjct: 326  KEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGH 385

Query: 1898 TP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
             P +IKGN+    V+F+YP+R    +L G N+    GQTVALVG SGCGKSTT+QLI+R
Sbjct: 386  KPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRL 445

Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
            YD   G++ ID  DIR+ +V +LR+ I +V QEP LF+ TI ENI YG  N+T D+++KA
Sbjct: 446  YDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKA 505

Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
               AN + F+M LP  +DT VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDT
Sbjct: 506  VKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 565

Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
            ESE  VQ ALDKAR GRT +VIAHRLST++NAD I    +G  +E+G+H  L+ + G+Y+
Sbjct: 566  ESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYF 625

Query: 2615 RLVEKQSS 2638
            +LV  Q+S
Sbjct: 626  KLVNMQTS 633


>gi|6981354|ref|NP_036822.1| ATP-binding cassette, sub-family B
            (MDR/TAP), member 4; ATP-binding cassette, sub-family B
            (MDR/TAP), member 4 (P-glycoprotein 3/ multidrug
            resistance 2); ATP-binding cassette sub-family B
            (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug
            resistance 2); P-glycoprotein 3/ multidrug resistance 2;
            ATP-binding cassette sub-family B (MDR/TAP) member 4
            (P-glycoprotein 3/ multidrug resistance 2 [Rattus
            norvegicus]
 gi|1170903|sp|Q08201|MDR2_RAT Multidrug resistance protein 2
            (P-glycoprotein 2)
 gi|543425|pir||S41646 p-glycoprotein - rat
 gi|310193|gb|AAA02937.1| P-glycoprotein
          Length = 1278

 Score =  656 bits (1693), Expect = 0.0
 Identities = 370/892 (41%), Positives = 536/892 (59%), Gaps = 15/892 (1%)
 Frame = +2

Query: 5    LKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWL 184
            +KILKG++ +V  G+TVALVG+SGCGKST++ LL R Y+   G I +DG  I+ +N+R L
Sbjct: 406  IKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGTISIDGQDIRNFNVRCL 465

Query: 185  RSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIGA 364
            R  IG+V QEP++F  T+AENIR G   +T  +I++A K ANA++FI KL  ++DT++G
Sbjct: 466  REFIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIKKAVKEANAYDFIMKLPQKFDTLVGD 525

Query: 365  GAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIA 544
               QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE  VQ ALDKA EGRTT+ IA
Sbjct: 526  RGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIA 585

Query: 545  HRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ-----------EIERA 691
            HRLST+RNA  I  F+ G+I E+G+H ELI K+ GIY  +V  Q           E+E +
Sbjct: 586  HRLSTVRNADVIAGFEDGVIVEQGSHSELIKKE-GIYFRLVNMQTSGSQILSEEFEVELS 644

Query: 692  XXXXXXXXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXX 871
                           R F   +     ++ L+ S A  + RL          VP
Sbjct: 645  DEKAAGGVAPNGWKARIFRNST-----KKSLKSSRAHQN-RLDVETNELDANVP------ 692

Query: 872  XXXXXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAG 1051
                         S   + +    E    ++  +  +  G   PAFSI+  ++  I   G
Sbjct: 693  -----------PVSFLKVLRLNKTEWPYFVVGTLCAIANGALQPAFSIILSEMIAIFGPG 741

Query: 1052 GDDVSI-KALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASY 1228
             D V   K  + SL F+ L      +  + G   GKAGE ++ RLR   F+ +++QD S+
Sbjct: 742  DDTVKQQKCNMFSLVFLGLGVHSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSW 801

Query: 1229 FDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXX 1408
            FDD +++ G+L++RLATDA  VQ A   RLA +     +L  G+ ++F YGW +  +
Sbjct: 802  FDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNTANLGTGIIISFIYGWQLTLLLLS 861

Query: 1409 XXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAA 1588
                           L    +RD      A ++ TE+I N +TV +LT++      +
Sbjct: 862  VVPFIAVAGIVEMKMLAGNAKRDKKEMEAAGKIATEAIENIRTVVSLTQERKFESMYVEK 921

Query: 1589 SKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNM 1768
               P+R ++ +     ++F+++ +F+ +++A  + FG +LI N       V  V  A+ +
Sbjct: 922  LHGPYRNSVRKAHIYGITFSISQAFMYFSYAGCFRFGSYLIVNGHMRFKDVILVFSAIVL 981

Query: 1769 ASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFA 1945
             ++++  A+S+ P+Y +A++SA  +F++  ++ +ID+    G  P   +G++    V F
Sbjct: 982  GAVALGHASSFAPDYAKAKLSAAYLFSLFERQPLIDSYSREGMWPDKFEGSVTFNEVVFN 1041

Query: 1946 YPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRD 2125
            YP R    VL G ++    GQT+ALVG SGCGKST +QL+ER+YD + G+V +D  + +
Sbjct: 1042 YPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVLLDGQEAKK 1101

Query: 2126 LSVKHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPD 2299
            L+V+ LR  + +V QEP LF+ +I +NI YG  +  ++QD++ +AA  ANIH F+  LP
Sbjct: 1102 LNVQWLRAQLGIVSQEPILFDCSIAKNIAYGDNSRVVSQDEIVRAAKEANIHPFIETLPQ 1161

Query: 2300 GYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARL 2479
             Y+T VG  G +LSGGQKQR+AIARA++R P++LLLDEATSALDTESEK+VQEALDKAR
Sbjct: 1162 KYETRVGDKGTQLSGGQKQRIAIARALIRQPRVLLLDEATSALDTESEKVVQEALDKARE 1221

Query: 2480 GRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            GRTC+VIAHRLSTIQNAD I+V  NGK  E GTHQ LLA++G+Y+ +V  Q+
Sbjct: 1222 GRTCIVIAHRLSTIQNADLIVVIDNGKVKEHGTHQQLLAQKGIYFSMVNIQA 1273



 Score =  331 bits (848), Expect = 6e-89
 Identities = 187/488 (38%), Positives = 278/488 (56%), Gaps = 1/488 (0%)
 Frame = +2

Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
            ++R   F  I++Q+  +FD        L +RL  D   +   I  ++      I + F G
Sbjct: 145  KIRQKFFHAILRQEMGWFDIK--GTTELNTRLTDDISKISEGIGDKVGMFFQAIATFFAG 202

Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
              V F  GW +  +                  L     +++ +  +A  +  E++   +T
Sbjct: 203  FIVGFIRGWKLTLVIMAITAILGLSTAVWAKILSTFSDKELAAYAKAGAVAEEALGAIRT 262

Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
            V A   Q    + +    ++  +  I + +  ++S  +A   +  ++A+A+ +G  L+ +
Sbjct: 263  VIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVIS 322

Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
               T      V  ++ + + SV  AA     +  AR +A ++F +I     ID+    G
Sbjct: 323  KEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFPNARGAAYVIFDIIDNNPKIDSFSERGH 382

Query: 1898 TP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
             P +IKGN+    V+F+YP+R    +L G N+    GQTVALVG SGCGKSTT+QL++R
Sbjct: 383  KPDSIKGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRL 442

Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
            YD   G++ ID  DIR+ +V+ LR+ I +V QEP LF+ TI ENI YG  N+T D+++KA
Sbjct: 443  YDPTEGTISIDGQDIRNFNVRCLREFIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIKKA 502

Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
               AN + F+M LP  +DT VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDT
Sbjct: 503  VKEANAYDFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 562

Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
            ESE  VQ ALDKAR GRT +VIAHRLST++NAD I    +G  +E+G+H  L+ + G+Y+
Sbjct: 563  ESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELIKKEGIYF 622

Query: 2615 RLVEKQSS 2638
            RLV  Q+S
Sbjct: 623  RLVNMQTS 630


>gi|1170902|sp|P43245|MDR1_RAT Multidrug resistance protein 1
            (P-glycoprotein 1)
 gi|92489|pir||JH0502 p-glycoprotein - rat
          Length = 1277

 Score =  655 bits (1690), Expect = 0.0
 Identities = 372/888 (41%), Positives = 542/888 (60%), Gaps = 13/888 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            E+KILKG++ +V  G+TVALVG+SGCGKST++ LL R Y+   G + +DG  I+  N+R+
Sbjct: 405  EVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIRTINVRY 464

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  IG+V QEP++F  T+AENIR G   +T  +IE+A K ANA++FI KL  ++DT++G
Sbjct: 465  LREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVG 524

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE +VQ ALDKA EGRTT+ I
Sbjct: 525  ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVI 584

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ----EIERAXXXXXX 709
            AHRLST+RNA  I  FD G+I E+G H+EL+ K+ GIY  +V  Q    EIE
Sbjct: 585  AHRLSTVRNADVIAGFDGGVIVEQGNHEELM-KEKGIYFKLVMTQTRGNEIEPGNNAYES 643

Query: 710  XXXXXXXXHRSFHRDSVTSDEERELQQSLAR--DSTRLRQSMISTTTQVPXXXXXXXXXX 883
                      S   +S +    R +++S+ R  D  R   S       VP
Sbjct: 644  QSDTGASELTS--EESKSPLIRRSIRRSIHRRQDQERRLSSKEDVDEDVPM--------- 692

Query: 884  XXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDV 1063
                     S + I K    E   +++ ++  +I G   P F+IV+ ++  + S   D
Sbjct: 693  --------VSFWQILKLNISEWPYLVVGVLCAVINGCIQPVFAIVFSKIVGVFSRDDDHE 744

Query: 1064 SIKALLN--SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDD 1237
            + +   N  SL F+++     ++    G   GKAGE ++ RLR  VF+++++QD S+FDD
Sbjct: 745  TKQRNCNLFSLLFLVMGMISFVTYFFQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDD 804

Query: 1238 SRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGV--GVAFYYGWNMAPIGXXX 1411
             ++  GSLT+RLA+DA NV+ A+  RLA V   + +L  G+   +   YGW +  +
Sbjct: 805  HKNTTGSLTTRLASDASNVKGAMGSRLAVVTQNVANLGTGIILSLVLVYGWQLTLLLVVI 864

Query: 1412 XXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAAS 1591
                          L  +  +D      + ++ TE+I N++TV +LT+++     +  +
Sbjct: 865  IPLIVLGGIIEMKLLSGQALKDKKELEISGKIATEAIENFRTVVSLTREQKFETMYAQSL 924

Query: 1592 KSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMA 1771
            + P+R A+ +     ++FA   + + +++A  + FG +L++    T   V  V  A+
Sbjct: 925  QIPYRNALKKAHVFGITFAFTQAMIYFSYAACFRFGAYLVARELMTFENVMLVFSAVVFG 984

Query: 1772 SMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFAY 1948
            +M+    +S+ P+Y +A++SA  +  +I +   ID+    G  P  ++GN+   GV F Y
Sbjct: 985  AMAAGNTSSFAPDYAKAKVSASHIIGIIEKIPEIDSYSTEGLKPNWLEGNVKFNGVKFNY 1044

Query: 1949 PNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDL 2128
            P R    VL G +     GQT+ LVG SGCGKST +QL+ER+Y+ + G+V +D  +I+ L
Sbjct: 1045 PTRPNIPVLQGLSFEVKKGQTLRLVGSSGCGKSTVVQLLERFYNPMAGTVFLDGKEIKQL 1104

Query: 2129 SVKHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDG 2302
            +V+ +R  + +V QEP LF+ +I ENI YG  +  ++ +++ +AA  ANIH F+  LP+
Sbjct: 1105 NVQCVR-ALGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIVRAAREANIHQFIDSLPEK 1163

Query: 2303 YDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLG 2482
            Y+T VG  G +LSGGQKQR+AIARA+VR P ILLLDEATSALDTESEK+VQEALDKAR G
Sbjct: 1164 YNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREG 1223

Query: 2483 RTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVE 2626
            RTCVVIAHRLSTIQNAD I+V +NG+  E GTHQ LLA++G+Y+ +V+
Sbjct: 1224 RTCVVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMVQ 1271



 Score =  340 bits (872), Expect = 1e-91
 Identities = 211/598 (35%), Positives = 316/598 (52%), Gaps = 24/598 (4%)
 Frame = +2

Query: 914  LFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALLNS- 1087
            +F +F+YA   +   + +  +  +I G   P   +V+G +    +   D  S +A+ N
Sbjct: 34   IFGMFRYADWLDKLCMALGTLAAIIHGTLLPLLMLVFGYMTDSFTPSRDPHSDRAITNQS 93

Query: 1088 ----------------LWFILLAFTG-GISTLISG----SLLGKAGETMSGRLRMDVFRN 1204
                            +      +TG G   LI      SL   A      ++R   F
Sbjct: 94   EINSTHTVSDTSLEEDMAMYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHA 153

Query: 1205 IMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGW 1384
            IM Q+  +FD +  + G L +RL  D   +   I  +L      I +   G  + F  GW
Sbjct: 154  IMNQEIGWFDVN--DAGELNTRLTDDVSKINDGIGDKLGMFFQSITTFSAGFIIGFISGW 211

Query: 1385 NMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEY 1564
             +  +                  L     +++ +  +A  +  E ++  +TV A   Q+
Sbjct: 212  KLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQKK 271

Query: 1565 MYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVF 1744
              + +    +   R  I + +  ++S  +A   V  ++A+A+ +G  L+ +N  +   V
Sbjct: 272  ELERYNKNLEEAKRVGIKKAITANISIGIAYLLVYASYALAFWYGTSLVLSNEYSIGQVL 331

Query: 1745 QVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNI 1921
             V  ++ + + S+   A     +  AR +A  +F +I  +  ID+    G  P +I GN+
Sbjct: 332  TVFFSILLGTFSIGHLAPNIEAFANARGAAYEIFKIIDNEPSIDSFSTKGHKPDSIMGNL 391

Query: 1922 NMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVK 2101
              + VYF YP+R    +L G N+    GQTVALVG SGCGKSTT+QL++R YD + G V
Sbjct: 392  EFKNVYFNYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVS 451

Query: 2102 IDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTF 2281
            ID  DIR ++V++LR+ I +V QEP LF  TI ENI YG EN+T D++EKA   AN + F
Sbjct: 452  IDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDF 511

Query: 2282 VMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEA 2461
            +M LP  +DT VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDTESE +VQ A
Sbjct: 512  IMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAA 571

Query: 2462 LDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            LDKAR GRT +VIAHRLST++NAD I     G  +E+G H+ L+  +G+Y++LV  Q+
Sbjct: 572  LDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIYFKLVMTQT 629


>gi|40644181|emb|CAC86600.1| multidrug resistance protein [Platichthys
            flesus]
          Length = 1292

 Score =  653 bits (1685), Expect = 0.0
 Identities = 364/888 (40%), Positives = 533/888 (59%), Gaps = 11/888 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            +++ILK +S  V  G+T+ALVG SGCGKST++ LL RFY+   G + +DG  I+  N+R+
Sbjct: 416  DVQILKNMSLSVKSGQTMALVGSSGCGKSTTVQLLQRFYDPQDGAVFVDGHDIRSLNVRY 475

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR  IG+V QEPI+F  T++ENIR G + +TDQ+IE+A K ANA++FI KL D+++T++G
Sbjct: 476  LREMIGVVSQEPILFATTISENIRYGRLDVTDQEIEQAAKEANAYDFIIKLPDKFETLVG 535

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
                Q+SGGQKQRVAIARA+VR P+ILLLDEATSALD ESE +VQ ALDK   GRTT+ +
Sbjct: 536  DRGTQMSGGQKQRVAIARALVRNPKILLLDEATSALDAESETIVQAALDKVRLGRTTIVV 595

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKA---QEIERAXXXXXXX 712
            AHRLSTIRNA  I  F  G +AE GTH +L+ K  GIY  +V     Q++E A
Sbjct: 596  AHRLSTIRNADVIAGFQDGQVAEVGTHSQLMEK-KGIYQRLVTTQTFQDVEEAKEA---- 650

Query: 713  XXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQ----SMISTTTQVPXXXXXXXXX 880
                         + ++ DE+  L  SL+  +   R+    S +S +
Sbjct: 651  ------------EEELSVDEKSPLADSLSECTPYRRKTTRGSSMSASEGGKEKTESDKDE 698

Query: 881  XXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDD 1060
                      S   + +   PE   +++  V  +I G   P F+I++ ++  + +    +
Sbjct: 699  TEEDENVPPVSFLKVLRLNLPEWPYMLVGTVCAIINGAMQPVFAIIFSKIITVFAEKDQE 758

Query: 1061 -VSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDD 1237
             V  +A L SL F ++     ++  + G   GK+GE ++ +LR+  F+ +M+QD S+FD+
Sbjct: 759  LVRQRATLFSLMFAVIGGVSFVTMFLQGFCFGKSGEILTLKLRLGAFKAMMRQDLSWFDN 818

Query: 1238 SRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXX 1417
             +++VG+LT+RLATDA  VQ A   R+A +     +L   V ++F YGW +  +
Sbjct: 819  PKNSVGALTTRLATDAAQVQGATGVRMATLAQNFANLGTSVIISFIYGWELTLLILAVVP 878

Query: 1418 XXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKS 1597
                        L      D     +A ++ TE+I N +TV +LT++      +    +
Sbjct: 879  AMVLAGAVEMKLLTGHAVEDKKELEKAGKISTEAIENIRTVASLTREPKFESLYHKNLEV 938

Query: 1598 PHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASM 1777
            P++ +  +      +FA + + + + +A  + FG WLI         VF VI A+   +M
Sbjct: 939  PYKNSTKKAHVYGATFAFSQAMIYFAYAGCFRFGAWLIEEGRMDVQGVFLVISAVLYGAM 998

Query: 1778 SVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYPN 1954
            ++  A S+ P Y +A++SA  +  ++  +  IDN    G+TP    GN++   V F YP+
Sbjct: 999  AIGEANSFAPNYAKAKMSASHLMMLMNLEPAIDNLSQEGETPDRFDGNVHFENVRFNYPS 1058

Query: 1955 RRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSV 2134
            R    VL G ++    G+T+ALVG SGCGKST IQL+ER+YD   GSV +D+ + + L++
Sbjct: 1059 RPNLPVLQGLDLEVKRGETLALVGSSGCGKSTIIQLLERFYDPREGSVVLDNVNTKQLNI 1118

Query: 2135 KHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYD 2308
              LR  + +V QEPTLF+ T+ +NI YG  +   T D++  AA  ANIH+F+  LP+ YD
Sbjct: 1119 HWLRSQMGIVSQEPTLFDCTLAQNIAYGDNSRIATMDEIVAAAKAANIHSFIQELPEKYD 1178

Query: 2309 TSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRT 2488
            T  G  G +LSGGQKQR+AIARAI+R+P +LLLDEATSALDTESEK+VQEALD+A  GRT
Sbjct: 1179 TQAGDKGTQLSGGQKQRIAIARAILRNPMLLLLDEATSALDTESEKVVQEALDQASKGRT 1238

Query: 2489 CVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
            C+++AHRLSTIQNAD+I V + G  +E+GTHQ LLA+RG+Y+ LV  Q
Sbjct: 1239 CIIVAHRLSTIQNADRIAVLQGGVVVEQGTHQQLLAKRGVYHMLVTTQ 1286



 Score =  332 bits (851), Expect = 3e-89
 Identities = 203/595 (34%), Positives = 321/595 (53%), Gaps = 23/595 (3%)
 Frame = +2

Query: 920  DIFKYA-SPEMRNIIISLVFTLIRGFTWPAFSIVYGQL---------------FKILSAG 1051
            D+F++A S ++  I+   V  +  G   P   IV+G +               F ++
Sbjct: 48   DVFRFADSLDIFMILCGTVMAMANGVVLPLMCIVFGDMTDSLVNFPTGEISDNFTVIYPN 107

Query: 1052 GDDVSIKALLN------SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQ 1213
               + I + L       ++++ ++  T  ++  +  SL   A      R+R   F  IMQ
Sbjct: 108  FTGLPINSTLQEDMNRYAIYYSIMGATVLVAAYLQVSLWTMAAGRQVKRIRKLFFHRIMQ 167

Query: 1214 QDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMA 1393
            QD  +FD +    G L +RL  D   +Q  I  + A ++    +      + F  GW +
Sbjct: 168  QDIGWFDVNE--TGELNTRLIDDVYKIQEGIGDKAAMLIQAYTTFLSAFVIGFTKGWKLT 225

Query: 1394 PIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYD 1573
             +                  L     ++  +  +A  +  E ++  +TV A + Q+
Sbjct: 226  LVILAVSPALGLSAALFSKVLTSFTSKEQAAYAKAGAVAEEVLAAIRTVFAFSGQDREIK 285

Query: 1574 AFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVI 1753
             +    +      I + L  ++S       +  ++A+A+ +G  LI +N  T  +V  V+
Sbjct: 286  RYHKNLEDAKIMGIKKALSANISMGFTFMVIYLSYALAFWYGSTLILSNEYTIGSVLTVL 345

Query: 1754 EALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMR 1930
              + + + ++  +++    +  AR +A  ++++I     ID+    G  P +IKGNI  +
Sbjct: 346  FVVLIGAFTMGQSSANIQTFASARGAAHKVYSIIDNNPTIDSYSEAGFKPDSIKGNIEFK 405

Query: 1931 GVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDD 2110
             ++F+YP R    +L   ++S   GQT+ALVG SGCGKSTT+QL++R+YD   G+V +D
Sbjct: 406  NIHFSYPTRPDVQILKNMSLSVKSGQTMALVGSSGCGKSTTVQLLQRFYDPQDGAVFVDG 465

Query: 2111 SDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMG 2290
             DIR L+V++LR+ I +V QEP LF  TI ENI YG  ++T  ++E+AA  AN + F++
Sbjct: 466  HDIRSLNVRYLREMIGVVSQEPILFATTISENIRYGRLDVTDQEIEQAAKEANAYDFIIK 525

Query: 2291 LPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDK 2470
            LPD ++T VG  G ++SGGQKQRVAIARA+VR+PKILLLDEATSALD ESE IVQ ALDK
Sbjct: 526  LPDKFETLVGDRGTQMSGGQKQRVAIARALVRNPKILLLDEATSALDAESETIVQAALDK 585

Query: 2471 ARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
             RLGRT +V+AHRLSTI+NAD I   ++G+  E GTH  L+ ++G+Y RLV  Q+
Sbjct: 586  VRLGRTTIVVAHRLSTIRNADVIAGFQDGQVAEVGTHSQLMEKKGIYQRLVTTQT 640


>gi|126930|sp|P23174|MDR3_CRIGR Multidrug resistance protein 3
            (P-glycoprotein 3)
 gi|2119778|pir||I48123 p-glycoprotein isoform III - Chinese hamster
 gi|191169|gb|AAA68885.1| p-glycoprotein isoform III
          Length = 1281

 Score =  653 bits (1684), Expect = 0.0
 Identities = 367/892 (41%), Positives = 533/892 (59%), Gaps = 15/892 (1%)
 Frame = +2

Query: 5    LKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWL 184
            +KILKG++ +V  G+TVALVG+SGCGK+T++ LL R Y+   G I +DG  I+ +N+R+L
Sbjct: 409  IKILKGLNLKVQSGQTVALVGNSGCGKTTTLQLLQRLYDPTEGTISIDGQDIRNFNVRYL 468

Query: 185  RSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIGA 364
            R  IG+V QEP++F  T+AENIR G   +T ++I++A K ANA+EFI KL  ++DT++G
Sbjct: 469  REIIGVVSQEPVLFSTTIAENIRYGRGNVTMEEIKKAVKEANAYEFIMKLPQKFDTLVGE 528

Query: 365  GAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIA 544
               QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE  VQ ALDKA EGRTT+ IA
Sbjct: 529  RGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIA 588

Query: 545  HRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQ-----------EIERA 691
            HRLST+RNA  I  F+ G+I E+G+H EL+ K+ G+Y  +V  Q           E+E +
Sbjct: 589  HRLSTVRNADVIAGFEDGVIVEQGSHSELMQKE-GVYFKLVNMQTSGSQILSQEFEVELS 647

Query: 692  XXXXXXXXXXXXXXHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPXXXXXX 871
                             F   +     ++ L+ S A    RL          VP
Sbjct: 648  EEKAADGMTPNGWKSHIFRNST-----KKSLKSSRAHHH-RLDVDADELDANVP------ 695

Query: 872  XXXXXXXXGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAG 1051
                         S   + K    E    ++  V  ++ G   PA SI+  ++  I   G
Sbjct: 696  -----------PVSFLKVLKLNKTEWPYFVVGTVCAIVNGALQPAISIILSEMIAIFGPG 744

Query: 1052 GDDVSI-KALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASY 1228
             D V   K  L SL F+ L      +  + G   GKAGE ++ RLR   F+ +++QD S+
Sbjct: 745  DDAVKQQKCNLFSLVFLGLGVLSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSW 804

Query: 1229 FDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXX 1408
            FDD +++ G+L++RLATD   VQ A   RLA +     +L  G+ ++F YGW +  +
Sbjct: 805  FDDYKNSTGALSTRLATDRAQVQGATGTRLALIAQNTANLGTGIIISFIYGWQLTLLLLS 864

Query: 1409 XXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAA 1588
                           L    +RD  +   A ++ TE+I N +TV +LT++      +
Sbjct: 865  VVPFIAVSGIVEMKMLAGNAKRDKKALEAAGKIATEAIENIRTVVSLTQERKFESMYVEK 924

Query: 1589 SKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNM 1768
               P+R ++       ++F+++ +F+ +++A  + FG +LI N       V  V  A+
Sbjct: 925  LHEPYRNSVQMAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVF 984

Query: 1769 ASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFA 1945
             ++++  A+S+ P+Y +A++SA  +F++  ++ +ID+    G  P   +G++    V F
Sbjct: 985  GAVALGHASSFAPDYAKAKLSAAHLFSLFERQPLIDSYSGEGLWPDKFEGSVTFNEVVFN 1044

Query: 1946 YPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRD 2125
            YP R    VL G ++    GQT+ALVG SGCGKST +QL+ER+YD + G+V +D  + +
Sbjct: 1045 YPTRANMPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVLLDGQEAKK 1104

Query: 2126 LSVKHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPD 2299
            L+++ LR  + +V QEP LF+ +I ENI YG  +  ++QD++ +AA  ANIH F+  LP
Sbjct: 1105 LNIQWLRAQLGIVSQEPVLFDCSIAENIAYGDNSRVVSQDEIVRAAKAANIHPFIETLPQ 1164

Query: 2300 GYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARL 2479
             Y T VG  G +LSGGQKQR+AI RA++R P++LLLDEATSALDTESEK+VQEALDKAR
Sbjct: 1165 KYKTRVGDKGTQLSGGQKQRLAIRRALIRQPRVLLLDEATSALDTESEKVVQEALDKARE 1224

Query: 2480 GRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            GRTC+VIAHRLSTIQNAD I+V +NGK  E GTHQ LLA++G+Y+ +V  Q+
Sbjct: 1225 GRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVNIQA 1276



 Score =  329 bits (844), Expect = 2e-88
 Identities = 183/488 (37%), Positives = 281/488 (57%), Gaps = 1/488 (0%)
 Frame = +2

Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
            ++R + F  I++Q+  +FD        L +RL  D   +   I  ++      + + F G
Sbjct: 148  KIRQNFFHAILRQEMGWFDIK--GTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAG 205

Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
              V F  GW +  +                  L     +++ +  +A  +  E++   +T
Sbjct: 206  FIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSTFSDKELAAYAKAGAVAEEALGAIRT 265

Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
            V A   Q    + +    ++  +  I + +  ++S  +A   +  ++A+A+ +G  L+ +
Sbjct: 266  VIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVIS 325

Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
               T      V  ++ + + SV  AA     +  AR +A ++F +I     ID+    G
Sbjct: 326  KEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGH 385

Query: 1898 TP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
             P +IKGN++   V+F+YP+R    +L G N+    GQTVALVG SGCGK+TT+QL++R
Sbjct: 386  KPDSIKGNLDFSDVHFSYPSRANIKILKGLNLKVQSGQTVALVGNSGCGKTTTLQLLQRL 445

Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
            YD   G++ ID  DIR+ +V++LR+ I +V QEP LF+ TI ENI YG  N+T ++++KA
Sbjct: 446  YDPTEGTISIDGQDIRNFNVRYLREIIGVVSQEPVLFSTTIAENIRYGRGNVTMEEIKKA 505

Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
               AN + F+M LP  +DT VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDT
Sbjct: 506  VKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 565

Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
            ESE  VQ ALDKAR GRT +VIAHRLST++NAD I    +G  +E+G+H  L+ + G+Y+
Sbjct: 566  ESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMQKEGVYF 625

Query: 2615 RLVEKQSS 2638
            +LV  Q+S
Sbjct: 626  KLVNMQTS 633


>gi|9961250|ref|NP_061337.1| ATP-binding cassette, subfamily B, member
            4 isoform B; P glycoprotein 3/multiple drug resistance 3;
            P-glycoprotein-3/multiple drug resistance-3; multiple
            drug resistance 3 [Homo sapiens]
          Length = 1286

 Score =  651 bits (1680), Expect = 0.0
 Identities = 366/890 (41%), Positives = 533/890 (59%), Gaps = 13/890 (1%)
 Frame = +2

Query: 5    LKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWL 184
            +KILKG++ +V  G+TVALVG SGCGKST++ L+ R Y+   G I +DG  I+ +N+ +L
Sbjct: 409  VKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYL 468

Query: 185  RSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIGA 364
            R  IG+V QEP++F  T+AENI  G   +T  +I++A K ANA+EFI KL  ++DT++G
Sbjct: 469  REIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGE 528

Query: 365  GAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIA 544
               QLSGGQKQR+AIARA+VR P+ILLLDEATSALDTESE  VQ ALDKA EGRTT+ IA
Sbjct: 529  RGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIA 588

Query: 545  HRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXXX 724
            HRLST+RNA  I  F+ G+I E+G+H EL+ K+ G+Y  +V  Q
Sbjct: 589  HRLSTVRNADVIAGFEDGVIVEQGSHSELMKKE-GVYFKLVNMQ----TSGSQIQSEEFE 643

Query: 725  XXXHRSFHRDSVTSDEERELQQSLARD--STRLRQSMISTTTQVPXXXXXXXXXXXXXXG 898
                ++  R +    + R  + S  ++  ++++ Q  +   T
Sbjct: 644  LNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETD------------GLEAN 691

Query: 899  AMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSI-KA 1075
                S   + K    E    ++  V  +  G   PAFS+++ ++  I   G D V   K
Sbjct: 692  VPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKC 751

Query: 1076 LLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVG 1255
             + SL F+ L      +  + G   GKAGE ++ RLR   F+ +++QD S+FDD +++ G
Sbjct: 752  NIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTG 811

Query: 1256 SLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXX 1435
            +L++RLATDA  VQ A   RLA +   I +L  G+ ++F YGW +  +
Sbjct: 812  ALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSG 871

Query: 1436 XXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAI 1615
                  L    +RD      A ++ TE+I N +TV +LT++      +      P+R ++
Sbjct: 872  IVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSV 931

Query: 1616 VRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAA 1795
             +     ++F+++ +F+ +++A  + FG +LI N       V  V  A+   ++++  A+
Sbjct: 932  QKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHAS 991

Query: 1796 SYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFAYPNRRRQLV 1972
            S+ P+Y +A++SA  +F +  ++ +ID+    G  P   +GNI    V F YP R    V
Sbjct: 992  SFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPV 1051

Query: 1973 LDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKID-------DSDIRDLS 2131
            L G ++    GQT+ALVG SGCGKST +QL+ER+YD L G+V +D         + + L+
Sbjct: 1052 LQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLN 1111

Query: 2132 VKHLRDNIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGY 2305
            V+ LR  + +V QEP LF+ +I ENI YG  +  ++QD++  AA  ANIH F+  LP  Y
Sbjct: 1112 VQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKY 1171

Query: 2306 DTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGR 2485
            +T VG  G +LSGGQKQR+AIARA++R P+ILLLDEATSALDTESEK+VQEALDKAR GR
Sbjct: 1172 ETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGR 1231

Query: 2486 TCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQS 2635
            TC+VIAHRLSTIQNAD I+V +NG+  E GTHQ LLA++G+Y+ +V  Q+
Sbjct: 1232 TCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1281



 Score =  331 bits (849), Expect = 5e-89
 Identities = 186/488 (38%), Positives = 279/488 (57%), Gaps = 1/488 (0%)
 Frame = +2

Query: 1178 RLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCG 1357
            ++R   F  I++Q+  +FD +  +   L +RL  D   +   I  ++      + + F G
Sbjct: 148  KIRQKFFHAILRQEIGWFDIN--DTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAG 205

Query: 1358 VGVAFYYGWNMAPIGXXXXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKT 1537
              V F  GW +  +                  L     +++ +  +A  +  E++   +T
Sbjct: 206  FIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRT 265

Query: 1538 VQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISN 1717
            V A   Q    + +    ++     I + +  ++S  +A   +  ++A+A+ +G  L+ +
Sbjct: 266  VIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVIS 325

Query: 1718 NWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGD 1897
               T      V  ++ + + SV  AA     +  AR +A ++F +I     ID+    G
Sbjct: 326  KEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGH 385

Query: 1898 TP-TIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERY 2074
             P +IKGN+    V+F+YP+R    +L G N+    GQTVALVG SGCGKSTT+QLI+R
Sbjct: 386  KPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRL 445

Query: 2075 YDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKA 2254
            YD   G++ ID  DIR+ +V +LR+ I +V QEP LF+ TI ENI YG  N+T D+++KA
Sbjct: 446  YDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKA 505

Query: 2255 ATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDT 2434
               AN + F+M LP  +DT VG  G +LSGGQKQR+AIARA+VR+PKILLLDEATSALDT
Sbjct: 506  VKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 565

Query: 2435 ESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYY 2614
            ESE  VQ ALDKAR GRT +VIAHRLST++NAD I    +G  +E+G+H  L+ + G+Y+
Sbjct: 566  ESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYF 625

Query: 2615 RLVEKQSS 2638
            +LV  Q+S
Sbjct: 626  KLVNMQTS 633


>gi|17567265|ref|NP_510126.1| P-GlycoProtein related (pgp-12)
            [Caenorhabditis elegans]
 gi|7499663|pir||T21266 hypothetical protein F22E10.1 - Caenorhabditis
            elegans
 gi|3876291|emb|CAA91799.1| Hypothetical protein F22E10.1
            [Caenorhabditis elegans]
          Length = 1318

 Score =  643 bits (1658), Expect = 0.0
 Identities = 363/888 (40%), Positives = 535/888 (59%), Gaps = 11/888 (1%)
 Frame = +2

Query: 2    ELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRW 181
            ++K+L G++  V PG +VALVGHSGCGKSTS+GLL R Y    G + +DG  ++  NI W
Sbjct: 431  KVKVLNGLNLTVKPGTSVALVGHSGCGKSTSVGLLTRLYEPEGGKVMIDGQDVRSLNIDW 490

Query: 182  LRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIG 361
            LR T+GIVQQEPI+F  T+  N+ +G+   T +D+   CKMANAH+FI K+ + Y+T+IG
Sbjct: 491  LRKTVGIVQQEPILFNDTIHNNLLIGNPSATREDMIRVCKMANAHDFIQKMPNGYETMIG 550

Query: 362  AGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCI 541
             G+VQLSGGQKQRVAIAR ++R P++LLLDEATSALD +SE +VQ+AL+ A++GRTT+ I
Sbjct: 551  DGSVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALNNAAKGRTTIMI 610

Query: 542  AHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAXXXXXXXXXX 721
            AHRLSTIR A KI+ F+ G+I E G H+EL++   G YA +V+AQ+ + +
Sbjct: 611  AHRLSTIREADKIVFFENGVIVESGNHEELVALG-GRYAKLVEAQKFKESDDIEDNGDEH 669

Query: 722  XXXXHRSFHRDSVTSDEE--RELQQSLARDSTRLRQSMISTTTQVPXXXXXXXXXXXXXX 895
                      D ++S +    +  +SLA     +  +    T  +
Sbjct: 670  EEETSTVGRHDRLSSRQVSFHKSCESLASADLEIGYASTFNTFTLKTAQEEIENEDFAEE 729

Query: 896  --------GAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAG 1051
                    G + +   DIFK A      + +   F ++RG      + ++G +F
Sbjct: 730  VQRVMEEDGVINSGYLDIFKNAQGNYLYLSVGTFFAILRGSELALLANMFGFVFAAFKEP 789

Query: 1052 GDDVSIKAL-LNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASY 1228
             D++ +KAL L  + ++ L     I+ +ISG+L     E +  + R+  F+N++ QDAS+
Sbjct: 790  EDEM-VKALGLIFILYVALGLFVFITQVISGTLFTIVAENLGLKFRVQSFKNLLYQDASF 848

Query: 1229 FDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXX 1408
            FD+  H  G L +RLA+DAPNV+A +D R+ +V+  I S+   +   + + W +A I
Sbjct: 849  FDNPAHAPGKLITRLASDAPNVKAVVDTRMLQVIYSITSITINLITGYIFCWRIA-IAGT 907

Query: 1409 XXXXXXXXXXXXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAA 1588
                          Y   R         EA ++  E I + KT+Q LT  +     +  A
Sbjct: 908  IMIVLFATMMISMAYKIARENLKQIRKDEAGKIAIEIIESVKTIQLLTSTQRFLTHYKDA 967

Query: 1589 SKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNM 1768
                H+  + +   QS++ A++ +F+ +   + Y  G  L+ +        F+ I  + M
Sbjct: 968  QLVQHKSEMRKSYIQSVNNAISQTFMYFAMFVCYGVGTPLMYHGIVEAEPTFRAINCMMM 1027

Query: 1769 ASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAY 1948
             S++VM ++  FPE+V+A+ +AG++F +I +KS   +  + G+   I+GN+    V F+Y
Sbjct: 1028 GSVAVMHSSHNFPEFVKAKTAAGMLFKLIYRKSKTGDV-MEGNNTEIRGNVLFESVKFSY 1086

Query: 1949 PNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDL 2128
            P R  Q V+   + SA+ GQTVALVGPSG GKST I ++ER+YD   G+++ID  +I+ L
Sbjct: 1087 PQRPMQPVMTDLHFSAHSGQTVALVGPSGTGKSTCIAMLERFYDVSGGALRIDGQNIKSL 1146

Query: 2129 SVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYD 2308
            S+ HLR  +ALVGQEP LF  TI+EN+ +GL++++ ++V +A  LAN   F+  LP G D
Sbjct: 1147 SLHHLRTQMALVGQEPRLFAGTIKENVCFGLKDVSVEKVHQALELANASRFLANLPAGID 1206

Query: 2309 TSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRT 2488
            T VG  GG+LSGGQKQR+AIARA+VRDPKILLLDEATSALD+ESE+ VQEALD+AR GRT
Sbjct: 1207 TEVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRT 1266

Query: 2489 CVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
            C+ IAHRLS+IQN+D I+   +G   E G H  L++ RG YY L++KQ
Sbjct: 1267 CITIAHRLSSIQNSDLIVYIDHGMVQEAGNHAHLMSLRGKYYNLIKKQ 1314



 Score =  311 bits (796), Expect = 7e-83
 Identities = 189/582 (32%), Positives = 307/582 (52%), Gaps = 8/582 (1%)
 Frame = +2

Query: 911  SLFDIFKYAS-PEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKIL---SAGGDDVSIKAL 1078
            +L  +F+YA   +   +   +  + I G   P   I+ G +   L   +A  DD    A+
Sbjct: 77   TLLGLFRYAERTDYALLCFGIFLSFISGIAQPGLGIIAGNITNSLLIHNATSDDFYDSAM 136

Query: 1079 LNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGS 1258
             N   F  +     I   +           ++ +++    ++I++Q+A +FD  +++ G+
Sbjct: 137  TNVWLFGGIGIIVLIVNFVQYMCFQYCCIRITSKMKQHYIQSILRQNAGWFD--KNHSGT 194

Query: 1259 LTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGXXXXXXXXXXXX 1438
            LT++L  +   +   I  +L  ++ G+V    G+ ++F+Y W +A +
Sbjct: 195  LTTKLHDNMERINEGIGDKLGVLIRGMVMFVAGIVISFFYEWRLALMMMGIGPLCCVCMS 254

Query: 1439 XXXXYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIV 1618
                 +     +++    +A  +  ES+   +TVQA   QE M + +T         AI
Sbjct: 255  LMSRSMSSFTSKELAGVGKAGSIAEESLMGVRTVQAFNGQEEMVEKYTVELGKGKSFAIQ 314

Query: 1619 RGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWS---TPYTVFQVIEALNMASMSVML 1789
            +GLW  +   +   F+   F     +G  L+   W    TP  VF V+ ++ + +  + L
Sbjct: 315  KGLWGGVFGGIFLLFLFSYFGGGIYYGGQLL--RWKIIETPGDVFIVVISMLIGAYFLGL 372

Query: 1790 AASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPT-IKGNINMRGVYFAYPNRRRQ 1966
             + +    + AR++A  ++ +I +   ID     G   T + G +    V+F YP R++
Sbjct: 373  ISPHLMVLLNARVAAATIYEIIDRTPDIDVYSTEGQKMTNVVGKVVFEEVHFRYPTRKKV 432

Query: 1967 LVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLR 2146
             VL+G N++   G +VALVG SGCGKST++ L+ R Y+   G V ID  D+R L++  LR
Sbjct: 433  KVLNGLNLTVKPGTSVALVGHSGCGKSTSVGLLTRLYEPEGGKVMIDGQDVRSLNIDWLR 492

Query: 2147 DNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGAS 2326
              + +V QEP LFN TI  N+  G  + T++ + +   +AN H F+  +P+GY+T +G
Sbjct: 493  KTVGIVQQEPILFNDTIHNNLLIGNPSATREDMIRVCKMANAHDFIQKMPNGYETMIGDG 552

Query: 2327 GGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAH 2506
              +LSGGQKQRVAIAR ++RDPK+LLLDEATSALD +SE +VQ AL+ A  GRT ++IAH
Sbjct: 553  SVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALNNAAKGRTTIMIAH 612

Query: 2507 RLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQ 2632
            RLSTI+ ADKI+   NG  +E G H+ L+A  G Y +LVE Q
Sbjct: 613  RLSTIREADKIVFFENGVIVESGNHEELVALGGRYAKLVEAQ 654



 Score =  202 bits (515), Expect = 3e-50
 Identities = 106/224 (47%), Positives = 152/224 (67%)
 Frame = +2

Query: 11   ILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWLRS 190
            ++  + F  + G+TVALVG SG GKST I +L RFY+   G +++DG  I+  ++  LR+
Sbjct: 1094 VMTDLHFSAHSGQTVALVGPSGTGKSTCIAMLERFYDVSGGALRIDGQNIKSLSLHHLRT 1153

Query: 191  TIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIGAGA 370
             + +V QEP +F  T+ EN+  G   ++ + + +A ++ANA  F+  L    DT +G
Sbjct: 1154 QMALVGQEPRLFAGTIKENVCFGLKDVSVEKVHQALELANASRFLANLPAGIDTEVGEKG 1213

Query: 371  VQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIAHR 550
             QLSGGQKQR+AIARA+VR P+ILLLDEATSALD+ESER VQ ALD+A EGRT + IAHR
Sbjct: 1214 GQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHR 1273

Query: 551  LSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEI 682
            LS+I+N+  I+  D G++ E G H  L+S   G Y +++K Q++
Sbjct: 1274 LSSIQNSDLIVYIDHGMVQEAGNHAHLMSL-RGKYYNLIKKQDL 1316




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